14,217 results match your criteria Journal of Surgical Research[Journal]


Postoperative Pain and Opioid Use After Thyroid and Parathyroid Surgery-A Pilot, Prospective SMS-Based Survey.

J Surg Res 2019 Apr 17;240:236-240. Epub 2019 Apr 17.

University of California San Francisco, Section of Endocrine Surgery, San Francisco, California.

Background: New persistent opioid use has been identified following minor surgical procedures and may contribute to the national opioid epidemic. Prescription patterns vary and we have limited data on patient pain experiences in the outpatient setting. We devised a novel short messaging service survey to record pain scores and opioid use following outpatient thyroid or parathyroid surgery. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.016DOI Listing

Inhibition of 3β-Hydroxysteroid Dehydrogenase Type 1 Suppresses Interleukin-6 in Breast Cancer.

J Surg Res 2019 Apr 17;241:8-14. Epub 2019 Apr 17.

Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan. Electronic address:

Background: Recently, we demonstrated that the expression of 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth. However, the mechanisms are unclear.

Methods: Triple-negative MDA-MB-231 and BT-20 breast cancer cells underwent HSD3B1 silencing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193014
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http://dx.doi.org/10.1016/j.jss.2019.03.024DOI Listing
April 2019
1 Read

Integrating Bleeding Control Training Into Surgical Missions in Low- and Middle-Income Countries.

J Surg Res 2019 Apr 17;241:53-56. Epub 2019 Apr 17.

Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Basic bleeding control (BCon) techniques can save lives globally but the knowledge is not widespread in low-income countries where trauma is a common cause of death. Short-term surgical missions (STSMs) are an effective route to share this public health initiative around the world.

Materials And Methods: Over 2017-2018, the International Surgical Health Initiative organized STSMs to locations in Sierra Leone, Bangladesh, Peru, and Ghana. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.020DOI Listing
April 2019
2 Reads

TREO Aortic Endograft Demonstrates Significant Aneurysmal Sac Shrinkage.

J Surg Res 2019 Apr 17;241:48-52. Epub 2019 Apr 17.

Division of Vascular Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, New York. Electronic address:

Background: Aneurysmal sac shrinkage is associated with successful aneurysm repair after endovascular aortic repair (EVAR). There are a variety of approved aortic endografts, with a recent study demonstrating increased sac shrinkage in certain endografts compared with others. The TREO endograft (Terumo Aortic Ltd, Renfrewshire, Scotland, UK) is being evaluated for use in EVAR, with preliminary data demonstrating high rates of success. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193016
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http://dx.doi.org/10.1016/j.jss.2019.03.048DOI Listing
April 2019
1 Read

Sevoflurane Promotes Regeneration of the Endothelial Glycocalyx by Upregulating Sialyltransferase.

J Surg Res 2019 Apr 17;241:40-47. Epub 2019 Apr 17.

Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Background: During ischemia-reperfusion injury, the endothelial glycocalyx is damaged by oxidative stress-induced release of hydrogen peroxide, leading to decreased endothelium-dependent vasodilation. The regenerative effects of sevoflurane on the endothelial glycocalyx and endothelium-dependent vasodilation in oxidative stress remain unclear. Sialic acid, which is a component of the glycocalyx, plays a key role in antioxidant activity and is catalyzed by the sialyltransferase, ST6Gal-I. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.018DOI Listing

Perioperative Morbidity of Gastrectomy During CRS-HIPEC: An ACS-NSQIP Analysis.

J Surg Res 2019 Apr 17;241:31-39. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Formal gastrectomy is occasionally required to achieve complete cytoreduction for patients with peritoneal surface malignancies. In addition, the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with gastric cancer is increasingly being explored. Nevertheless, data on the safety of gastrectomy at the time of CRS-HIPEC are limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193015
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http://dx.doi.org/10.1016/j.jss.2019.03.036DOI Listing
April 2019
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Phosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli-Induced Lung Injury.

J Surg Res 2019 Apr 17;241:24-30. Epub 2019 Apr 17.

Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu-Chi University, Hualien, Taiwan. Electronic address:

Background: Pulmonary air embolism (PAE)-induced acute lung injury (ALI) can be caused by massive air entry into the lung circulation. PAE can occur during diving, aviation, and some iatrogenic invasive procedures. PAE-induced ALI presents with severe inflammation, hypoxia, and pulmonary hypertension, and it is a serious complication resulting in significant morbidity and mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193014
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http://dx.doi.org/10.1016/j.jss.2019.03.028DOI Listing
April 2019
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Cost-Effectiveness of Sentinel Lymph Node Biopsy for Head and Neck Cutaneous Squamous Cell Carcinoma.

J Surg Res 2019 Apr 17;241:15-23. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Sentinel lymph node biopsy (SLNB) has shown promise in identifying subclinical nodal metastasis in patients with high-risk cutaneous squamous cell carcinoma. However, low metastasis rates may indicate that performing such a procedure in all patients may be unnecessary and costly.

Materials And Methods: A decision model was developed to analyze costs and survival in patients with head and neck cutaneous squamous cell carcinoma based on their tumor and nodal metastasis staging and whether or not they received an SLNB. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.040DOI Listing

Indocyanine Green Fluorescence Imaging of the Tracheal Blood Flow During Esophagectomy.

J Surg Res 2019 Apr 17;241:1-7. Epub 2019 Apr 17.

Department of Digestive Surgery, Osaka International Cancer Institute, Chuo-ku, Osaka, Japan.

Background: Tracheobronchial ischemia and necrosis are uncommon causes of pulmonary complications that can be lethal on development. Surgical manipulation considering tracheal blood flow is important in radical esophagectomy with extensive lymph node dissection. This study introduces a novel method for assessing tracheal blood perfusion using indocyanine green (ICG) fluorescence imaging. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.019DOI Listing

Cost-Effectiveness of Negative Pressure Incision Management System in Cardiac Surgery.

J Surg Res 2019 Apr 15;240:227-235. Epub 2019 Apr 15.

Division of Thoracic & Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia.

Background: Sternal wound infections (SWIs) can be a devastating long-term complication with significant morbidity and health care cost. The purpose of this analysis was to evaluate the cost-effectiveness of negative pressure incision management systems (NPIMS) in cardiac surgery.

Materials And Methods: All cardiac surgery cases at an academic hospital with risk scores available (2009-2017) were extracted from an institutional database (n = 4455). Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.046DOI Listing

Next Generation of Global Surgeons: Aligning Interest With Early Access to Global Surgery Education.

J Surg Res 2019 Apr 12;240:219-226. Epub 2019 Apr 12.

Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

Background: Although interest in global surgery is increasing among medical students, several questions remain unanswered such as: the association of demographics with said interest, the extent that global surgical burden education has been integrated into medical education, and the availability of global surgery electives. This study aimed to assess the current state of global surgery education in the United States (U.S. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.009DOI Listing

Surgical Site Infection After Gastrointestinal Surgery in China: A Multicenter Prospective Study.

J Surg Res 2019 Apr 12;240:206-218. Epub 2019 Apr 12.

Department of Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, P.R. China; Department of Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, P.R. China. Electronic address:

Background: There is no nationwide database of information on surgical site infection (SSI) after gastrointestinal surgery in China. This study aimed to determine the incidence of SSI after gastrointestinal surgery in China and evaluate the related risk factors.

Materials And Methods: The multicenter, prospective, observational study enrolled adult patients who underwent gastrointestinal surgery from May 1, 2018 to June 30, 2018 in 30 hospitals in China. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.017DOI Listing

Determining Trajectory to Predict Injury: The Use of X-Ray During Resuscitation in Gunshot Wounds.

J Surg Res 2019 Apr 9;240:201-205. Epub 2019 Apr 9.

Division of Trauma, Department of Surgery, Cooper University Hospital, Camden, New Jersey. Electronic address:

Background: The practice of marking gunshot wounds and obtaining X-rays (XRs) has been performed to determine the trajectory of missiles to help identify internal injuries. We hypothesized that surgeons would have poor accuracy in predicting injuries and that X-rays do not alter the clinical decision.

Methods: We developed a 50-patient (89 injury sites) PowerPoint survey based on cases seen at our level 1 trauma center from 2012 to 2014. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.065DOI Listing

Factors Associated With the Interhospital Transfer of Emergency General Surgery Patients.

J Surg Res 2019 Apr 9;240:191-200. Epub 2019 Apr 9.

Department of Surgery, University of Wisconsin, Madison, Wisconsin.

Background: Transferred emergency general surgery (EGS) patients constitute a highly vulnerable, acutely ill population. Guidelines to facilitate timely, appropriate EGS transfers are lacking. We determined patient- and hospital-level factors associated with interhospital EGS transfers, a critical first step to identifying which patients may require transfer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804183084
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http://dx.doi.org/10.1016/j.jss.2018.11.053DOI Listing
April 2019
2 Reads

Complication Rates for Pediatric Hepatectomy and Nephrectomy: A Comparison of NSQIP-P, PHIS, and KID.

J Surg Res 2019 Apr 4;240:182-190. Epub 2019 Apr 4.

Department of Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Division of Pediatric Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address:

Background: Three large national data sets are commonly used to assess operative outcomes in pediatric surgery; National Surgical Quality Improvement Program Pediatric (NSQIP-P), Pediatric Health Information System (PHIS), and Kids' Inpatient Data set (KID). Hepatectomy and nephrectomy are rare pediatric surgical procedures, which may benefit from large administrative data sets for the assessment of short-term complications.

Materials And Methods: A retrospective review of NSQIP-P (2012-2015), KID (2012), and PHIS (2012-2015) was performed for hepatectomy or nephrectomy cases for children aged 0 to 18 y. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.005DOI Listing
April 2019
2 Reads

Refugee Access to Surgical Care in Lebanon: A Post Hoc Analysis of the SCAR Study.

J Surg Res 2019 Apr 3;240:175-181. Epub 2019 Apr 3.

Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Lebanon hosts an estimated one million Syrian refugees registered with the United Nations High Commissioner for Refugees (UNHCR). The UNHCR contracts with select Lebanese hospitals to provide affordable primary and emergency care to refugees. We aimed to assess the surgical capabilities of UNHCR-affiliated hospitals in Lebanon. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.007DOI Listing
April 2019
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Empowering Bystanders to Intervene: Trauma Responders Unify to Empower (TRUE) Communities.

J Surg Res 2019 Jun;238:255-264

Department of Surgery, Northwestern University, Chicago, Illinois. Electronic address:

Background: Timely and effective bystander first aid can improve outcomes for trauma victims. Bystanders are present at most traumas and are more likely to assist with prior training.

Materials And Methods: An evidence-based course was created for the general public in high-risk Chicago neighborhoods focused on basic traumatic first aid, including scene management, hemorrhage control, and mitigating the psychological impact of trauma to overcome the bystander effect. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.029DOI Listing

Adjuvant Chemotherapy Guidance in Young Breast Cancer Patients With Luminal Subtypes and Stage pT1N0.

J Surg Res 2019 Apr 2;240:165-174. Epub 2019 Apr 2.

Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: This study evaluated whether young breast cancer patients (≤ 40 y of age) with luminal subtypes and stage pT1N0 can benefit from chemotherapy (CHT).

Materials And Methods: This study included 688 patients aged ≤ 40 y with luminal subtypes and stage pT1N0 breast cancer. The overall survival and disease-free survival (DFS) rates in the whole cohort and subgroups were compared between patients receiving CHT followed by endocrinotherapy (ET) (CHT→ET group) and those receiving only ET (ET-alone group). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.059DOI Listing
April 2019
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New Large Animal Model for Aortic Aneurysms in the Viscerorenal Segment.

J Surg Res 2019 Mar 29;240:156-164. Epub 2019 Mar 29.

European Vascular Centre Aachen-Maastricht, Department of Vascular Surgery, RWTH University Hospital Aachen, Aachen, Germany.

Background: Aortic aneurysms in the viscerorenal-segment are nowadays treatable by endovascular means. Previously, new endograft techniques were only tested in healthy animals. We aimed to establish a new large animal model for testing complex endovascular stent techniques preclinically. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.054DOI Listing
March 2019
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Close to the Bedside: A Systematic Review of Endogenous Retroviruses and Their Impact in Oncology.

J Surg Res 2019 Mar 29;240:145-155. Epub 2019 Mar 29.

Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia; Division of Pediatric Surgery, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address:

Background: Human endogenous retroviruses (HERVs) are genetic elements in the human genome, which resulted from ancient retroviral germline infections. HERVs have strong transcriptional promoters and enhancers that affect a cell's transcriptome. They also encode proteins that can exert effects in human cells. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.009DOI Listing
March 2019
2 Reads

Combined Hartmann's Reversal and Abdominal Wall Reconstruction: Defining Postoperative Morbidity.

J Surg Res 2019 Mar 28;240:136-144. Epub 2019 Mar 28.

Division of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota.

Background: Ventral hernias are common after Hartmann's procedure and add complexity to Hartmann's reversal. Colostomy reversal and abdominal wall reconstruction may be performed in a staged or concurrent fashion, although data are limited as to which strategy is optimal. We aimed to define the complication profile of concurrent abdominal wall reconstruction with colostomy reversal as compared to either procedure alone. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.044DOI Listing

RAS Mutation Status Confers Prognostic Relevance in Patients Treated With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Cancer.

J Surg Res 2019 Mar 28;240:130-135. Epub 2019 Mar 28.

Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

Background: Metastatic colorectal cancer (mCRC) with peritoneal carcinomatosis is an increasingly prevalent disease that carries significant mortality if left untreated. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) in this patient population is associated with improved outcomes but high morbidity. We sought to study the prognostic significance of the known genomic driver, RAS, in patients with mCRC undergoing CRS/HIPEC to allow for improved assessment of risk-benefit ratio in this patient population. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.050DOI Listing
March 2019
1 Read

Outcomes and Cost Comparison of Percutaneous Endovascular Aortic Repair versus Endovascular Aortic Repair With Open Femoral Exposure.

J Surg Res 2019 Mar 28;240:124-129. Epub 2019 Mar 28.

Division of Vascular Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

Background: The objective of this study was to assess cost differences between patients who underwent percutaneous endovascular aortic repair (PEVAR) and open surgical femoral exposure in elective endovascular aortic repair (EVAR) of abdominal aortic aneurysms.

Materials And Methods: An IRB-approved single center retrospective analysis of patients who underwent elective EVAR for abdominal aortic aneurysms from 2009 to 2016 was performed. One hundred patients were selected with 50 patients who underwent PEVAR and 50 patients who underwent open surgical femoral exposure. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.011DOI Listing
March 2019
2 Reads

IFN-γ Promotes Epithelial-Mesenchymal Transition and the Expression of PD-L1 in Pancreatic Cancer.

J Surg Res 2019 Mar 27;240:115-123. Epub 2019 Mar 27.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Tumor immune reactions not only provide host defense but also accelerate tumor immune escape and phenotype switching. Here, we examined the association of programmed cell death ligand 1 (PD-L1) expression with epithelial-mesenchymal transition (EMT)-associated markers in pancreatic ductal adenocarcinoma (PDA) within the context of the tumor microenvironment.

Materials And Methods: PDA samples from 36 patients were analyzed for PD-L1, vimentin, E-cadherin, and Snail expressions and for PDA cell and immune cell infiltration. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.038DOI Listing

Laparoscopic Splenectomy: Has It Become the Standard Surgical Approach in Pediatric Patients?

J Surg Res 2019 Mar 26;240:109-114. Epub 2019 Mar 26.

Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa. Electronic address:

Background: Splenectomy is often required in the pediatric population as part of the treatment of hematologic disorders and can be performed laparoscopically or open. We evaluated the comparative effectiveness of laparoscopic (LS) and open (OS) splenectomies using the American College of Surgeons National Surgical Quality Improvement Program Pediatric (NSQIP-P) data set.

Methods: The NSQIP-P data set was used to identify children who underwent elective splenectomy between January 2012 and December 2016. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.045DOI Listing

Diagnostic Utilization and Accuracy of Pediatric Appendicitis Imaging at Adult and Pediatric Centers.

J Surg Res 2019 Mar 25;240:97-103. Epub 2019 Mar 25.

Division of Pediatric Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pediatric Surgery, Children's Health, Dallas, Texas. Electronic address:

Background: Diagnostic imaging in pediatric appendicitis may decrease rates of negative appendectomy and identify alternate pathologies. We compared imaging practices for children transferred from nonpediatric facilities versus directly admitted to our tertiary children's hospital for laparoscopic appendectomy, and assessed the diagnostic accuracy in each population based on final pathologic diagnosis.

Materials And Methods: After institutional review board approval, all cases of laparoscopic appendectomy at our children's hospital during 2015 were reviewed. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.047DOI Listing
March 2019
2 Reads

A Novel Model Predicts Postoperative Pathology of Colorectal High-Grade Intraepithelial Neoplasia.

J Surg Res 2019 Mar 25;240:104-108. Epub 2019 Mar 25.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background: To analyze the consistency of endoscopic biopsy of colorectal high-grade intraepithelial neoplasia (HGIN) and pathological diagnosis and to explore the value of preoperative examination in differentiating HGIN from invasive carcinoma.

Methods: Clinicopathological data of 79 patients with colorectal HGIN undergoing preoperative endoscopic biopsy from January 2012 to December 2017 were retrospectively analyzed.

Results: Pathologically, 57 cases (72. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.042DOI Listing
March 2019
2 Reads

Room for Improvement: Barriers and Strategies to Improve Gender Parity for American Board of Surgery Certifying Examiners.

Authors:
Abbey L Fingeret

J Surg Res 2019 May 7;237:136-137. Epub 2018 Jul 7.

Division of Surgical Oncology, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2018.06.009DOI Listing

Is There Gender Bias on the American Board of Surgery General Surgery Certifying Examination?

J Surg Res 2019 May 4;237:131-135. Epub 2018 Jul 4.

The American Board of Surgery, Philadelphia, Pennsylvania.

Background: When oral examinations are administered, examiner subjectivity may possibly affect ratings, particularly when examiner severity is influenced by examinee characteristics (e.g., gender) that are independent of examinee ability. Read More

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http://dx.doi.org/10.1016/j.jss.2018.06.014DOI Listing

Trauma Recidivism and Mortality Following Violent Injuries in Young Adults.

J Surg Res 2019 May;237:140-147

Division of Gastrointestinal and Minimally Invasive Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, North Carolina. Electronic address:

Background: Trauma recidivism accounts for approximately 44% of emergency department admissions and remains a significant health burden with this patient cohort carrying higher rates of morbidity and mortality.

Methods: A level 1 trauma center registry was queried for patients aged 18-25 y presented between 2009 and 2015. Patients with nonaccidental gunshot wounds, stab wounds, or blunt assault-related injuries were categorized as violent injuries. Read More

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http://dx.doi.org/10.1016/j.jss.2018.09.006DOI Listing

Tumor Size Improves the Accuracy of the Prognostic Prediction of Lymph Node-Negative Gastric Cancer.

J Surg Res 2019 Mar 23;240:89-96. Epub 2019 Mar 23.

Department of Gastrointestinal Oncology, The First Affiliated Hospital of Hainan Medical University, Haikou City, China. Electronic address:

Background: Tumor size has been regarded as the "T" stage of many solid tumors because of its effect on prognosis. However, the prognostic impact of tumor size in gastric cancer (GC) is still controversial.

Materials And Methods: A total of 436 patients with curatively resected GC and those without lymph node metastasis in our center were retrospectively enrolled. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.037DOI Listing

Clinician-to-Clinician Communication of Patient Goals of Care Within a Surgical Intensive Care Unit.

J Surg Res 2019 Mar 22;240:80-88. Epub 2019 Mar 22.

Center for Surgery and Public Health, Brigham & Women's Hospital, Boston, Massachusetts; Department of Surgery, Brigham and Women's Hospital, Boston Massachusetts.

Background: Little is known about the process by which inpatient teams document and convey goals of care (GOC) for critically ill surgical patients. We sought to explore clinician perspectives on the barriers and facilitators to clinician-to-clinician communication and delivery of goal-concordant patient care.

Methods: Purposive and snowball sampling were used to recruit a multidisciplinary sample of clinicians who held roles in a surgical intensive care unit at a single tertiary care facility. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.036DOI Listing
March 2019
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Nonoperative Management Is Cost-Effective in Patients With Perforated Appendicitis With Longer Days of Symptoms.

J Surg Res 2019 Mar 22;240:70-79. Epub 2019 Mar 22.

Division of Pediatric Surgery, Children's Hospital Los Angeles, Los Angeles, California; Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:

Background: Management of perforated appendicitis in children remains controversial. Nonoperative (NO) and immediate operative (IO) strategies are used with varying outcomes. We hypothesized that IO intervention for patients with perforated appendicitis would be more cost-effective than NO management. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.033DOI Listing

The Impact of Race and Socioeconomic Status on Treatment and Outcomes of Blunt Splenic Injury.

J Surg Res 2019 Mar 22;240:60-69. Epub 2019 Mar 22.

Division of Trauma and Critical Care and Acute Care Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.

Background: Racial, ethnic, and socioeconomic disparities have been shown to exist in trauma patients. Management of blunt splenic injuries (BSIs) can include splenectomy, embolization, or nonoperative management. This study assesses the effect of race and insurance status on outcomes in patients after blunt splenic trauma. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.040DOI Listing

MicroRNA-7 Exerts Antiangiogenic Effect on Colorectal Cancer via ERK Signaling.

J Surg Res 2019 Mar 22;240:48-59. Epub 2019 Mar 22.

Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background: Recent studies have suggested that microRNA-7 (miR-7) family members may play important roles in human cancer by regulating cell proliferation, apoptosis, migration, and invasion. Therefore, the present study aimed to investigate the clinical significance and biological function of miR-7 in colorectal cancer (CRC).

Methods: Initially, cancer and adjacent tissues were collected from 76 patients with CRC. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.035DOI Listing

Impact of Traumatically Brain-Injured Donors on Outcomes After Heart Transplantation.

J Surg Res 2019 Mar 22;240:40-47. Epub 2019 Mar 22.

Division of Cardiac Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

Background: Heart transplant recipients of traumatically brain-injured (TBI) donors have been reported to have inferior survival and increased rates of cardiac allograft vasculopathy in single-center studies. This study sought to examine the impact of TBI donors on outcomes after heart transplantation across all transplantation centers.

Methods: We identified all adult heart transplants performed during 2007-2016 in the OPTN database. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193011
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http://dx.doi.org/10.1016/j.jss.2019.02.049DOI Listing
March 2019
3 Reads

Surgery Is Physically Demanding and Associated With Multisite Musculoskeletal Pain: A Cross-Sectional Study.

J Surg Res 2019 Mar 22;240:30-39. Epub 2019 Mar 22.

Clinical Institute, University of Southern Denmark, Odense, Denmark; Department of Pelvic Cancer, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden.

Background: Performing surgery involves well-known risk factors for developing musculoskeletal pain. Multisite musculoskeletal pain has shown to have an even higher adverse impact on the individual. We examined prevalence and intensity of multisite musculoskeletal pain in surgeons and identified characteristics associated with two or more painful body sites. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.048DOI Listing

Glucose to Lymphocyte Ratio as a Prognostic Marker in Patients With Resected pT2 Gallbladder Cancer.

J Surg Res 2019 Mar 22;240:17-29. Epub 2019 Mar 22.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea; Pancreatobiliary Cancer Center, Yonsei Cancer Center, Severance Hospital, Seoul, South Korea. Electronic address:

Background: We designed a clinical application of glucose to lymphocyte ratio (GLR) as it might be a sensitive parameter to determine the glucose metabolism and behavior of the cancer (i.e., its aggressiveness), and the immunologic status of a patient with cancer. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.043DOI Listing
March 2019
2 Reads

The Educational Role of Autonomy in Medical Training: A Scoping Review.

J Surg Res 2019 Mar 22;240:1-16. Epub 2019 Mar 22.

Division of General Surgery, Department of Surgery, Faculty of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Background: Recent limits imposed on autonomy have raised concern regarding the quality of medical training. The impact of autonomy on medical education has not been comprehensively reviewed. A scoping review was performed to understand the significance of autonomous practice in medical training. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193010
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http://dx.doi.org/10.1016/j.jss.2019.02.034DOI Listing
March 2019
3 Reads

Minimizing Opioid Prescribing in Surgery (MOPiS) Initiative: An Analysis of Implementation Barriers.

J Surg Res 2019 Mar 22;239:309-319. Epub 2019 Mar 22.

Surgical Outcomes and Quality Improvement Center (SOQIC), Department of Surgery and Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

Background: The United States is in the midst of an opioid epidemic. In response, our institution developed the Minimizing Opioid Prescribing in Surgery (MOPiS) initiative. MOPiS is a multicomponent intervention including: (1) patient education on opioid safety and pain management expectations; (2) clinician education on safe opioid prescribing; (3) prescribing data feedback; (4) patient risk screening to assess for addictive behavior; and (5) optimizations to the electronic health record (EHR). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193012
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http://dx.doi.org/10.1016/j.jss.2019.03.006DOI Listing
March 2019
12 Reads

Prone Positioning During Ex Vivo Lung Perfusion Influences Regional Edema Accumulation.

J Surg Res 2019 Mar 19;239:300-308. Epub 2019 Mar 19.

Leuven Lung Transplant Unit, Katholieke Universiteit Leuven, Leuven, Belgium.

Background: Ex vivo lung perfusion (EVLP) is developed to increase the quantity and quality of suitable grafts for lung transplantation. Standardly, lungs are mounted supine with the risk of fluid accumulation in the dorsal regions. Therefore, we investigated the impact of experimental prone position on graft function during EVLP. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.003DOI Listing
March 2019
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The Optimal Length of Stay Associated With the Lowest Readmission Risk Following Surgery.

J Surg Res 2019 Mar 19;239:292-299. Epub 2019 Mar 19.

Center for Surgery and Public Health, Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Index length of stay (LOS) and readmissions are viewed as important quality measures. However, these metrics represent competing demands as an inordinate reduction in LOS may lead to unplanned readmissions. We sought to assess the optimal LOS associated with the lowest 90-d readmission rate following discharge after common surgical procedures. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.032DOI Listing
March 2019
1 Read
1.936 Impact Factor

Outcomes of Ventral Hernia Repair in Solid Organ Transplant Patients: A Regression Analysis of the National Inpatient Sample.

J Surg Res 2019 Mar 18;239:284-291. Epub 2019 Mar 18.

Department of Surgery, Rutgers, New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Solid organ transplant has been identified as an independent risk factor in ventral hernia repair. Previous studies have generally focused on case studies or small samples. We sought to investigate the impact of liver or kidney transplant on ventral hernia repair outcomes using a nationally representative sample. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.016DOI Listing
March 2019
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Malignant Phyllodes Tumors of the Breast: Association Between Race, Clinical Features, and Outcomes.

J Surg Res 2019 Mar 18;239:278-283. Epub 2019 Mar 18.

Department of Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania. Electronic address:

Background: We sought to investigate associations between race, clinical characteristics, and outcomes among patients with malignant phyllodes of the breast.

Methods: Malignant phyllodes cases were identified using Surveillance Epidemiology and End Results database. We used chi-square tests to compare characteristics between racial groups and multinomial logistic regression to calculate relative risk ratios (RRR) and 95% confidence intervals (CI) comparing the likelihood of having particular characteristics by race. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.054DOI Listing
March 2019
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Expanding Hydrophobically Modified Chitosan Foam for Internal Surgical Hemostasis: Safety Evaluation in a Murine Model.

J Surg Res 2019 Mar 15;239:269-277. Epub 2019 Mar 15.

Regenerative Bioscience Center, University of Georgia, Athens, Georgia. Electronic address:

Background: A novel injectable expanding foam based on hydrophobically modified chitosan (HM-CS) was developed to improve hemostasis during surgeries. HM-CS is an amphiphilic derivative of the natural biopolymer chitosan (CS); HM-CS has been shown to improve the natural hemostatic characteristics of CS, but its internal safety has not been systematically evaluated. The goal of this study was to compare the long-term in vivo safety of HM-CS relative to a commonly used fibrin sealant (FS), TISSEEL (Baxter). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.060DOI Listing
March 2019
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The Resident Report Card: A Tool for Operative Feedback and Evaluation of Technical Skills.

J Surg Res 2019 Mar 15;239:261-268. Epub 2019 Mar 15.

Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Background: Competency-based medical education surgical curriculums will require frequent, recorded trainee performance evaluations. It is our hypothesis that written feedback after each operation can be used to chart surgical progress, can identify underperforming trainees, and will prove beneficial for resident learning.

Methods: The resident report card (RRC) is an online, easy-to-use evaluation tool designed to facilitate the creation and distribution of resident technical assessments. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.006DOI Listing

Current Pattern of Use and Impact of Pringle Maneuver in Liver Resections in the United States.

J Surg Res 2019 Mar 8;239:253-260. Epub 2019 Mar 8.

Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Background: Pringle maneuver (PM) is used for inflow vascular control during hepatectomy, but its use remains controversial. We aimed to report its pattern of use and association with postoperative outcomes.

Methods: We identified hepatectomy patients using the liver-targeted National Surgical Quality Improvement Program database (2014-2016). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.043DOI Listing

Heterogeneous Pulmonary Response After Tracheal Occlusion: Clues to Fetal Lung Growth.

J Surg Res 2019 Mar 8;239:242-252. Epub 2019 Mar 8.

Division of Pediatric Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

Background: Understanding inconsistent clinical outcomes in infants with severe congenital diaphragmatic hernia (CDH) after tracheal occlusion (TO) is a crucial step for advancing neonatal care. The objective of this study is to explore the heterogeneous airspace morphometry and the metabolic landscape changes in fetal lungs after TO.

Methods: Fetal lungs on days 1 and 4 after TO were examined using mass spectrometry-based metabolomics, fluorescence lifetime imaging microscopy (FLIM), the number of airspaces, and tissue-to-airspace ratio (TAR). Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.015DOI Listing
March 2019
3 Reads

Feasibility and Perceived Usefulness of Using Head-Mounted Cameras for Resident Video Portfolios.

J Surg Res 2019 Mar 8;239:233-241. Epub 2019 Mar 8.

Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: There is limited guidance on how to longitudinally administer simulation materials or to incorporate video recordings into assessment portfolios of simulated surgical skills.

Materials And Methods: We launched a longitudinal weekly simulation curriculum for PGY1-PGY3 surgical residents based on the ACS/APDS Curriculum. Residents underwent monthly objective structured assessment of technical skills (OSATS) while wearing head-mounted cameras. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.041DOI Listing

Growing Trends of Contralateral Prophylactic Mastectomy and Reconstruction in Young Breast Cancer.

J Surg Res 2019 Mar 8;239:224-232. Epub 2019 Mar 8.

Department of Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. Electronic address:

Background: The aim of this study was to evaluate the trends of surgical treatments among young patients in TNM stage based on the Surveillance, Epidemiology, and End Results database.

Materials And Methods: Patients aged less than 40 y diagnosed between 1998 and 2015 were enrolled, with tumors in TNM stage and not located in the central area. Differences in clinical-pathological characteristics were evaluated using chi-square tests. Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.002DOI Listing