14,119 results match your criteria Journal of Surgical Research[Journal]


Functional Expression of Mucin1 in Human Duodenal Adenocarcinoma.

J Surg Res 2019 Feb 11;238:79-89. Epub 2019 Feb 11.

Department of Surgery, Jichi Medical University, Tochigi, Japan.

Objective: Mucin1 (MUC1), a member of the mucin family, is a glycoprotein which is often expressed in malignant cells. However, the expression and function of MUC1 in human duodenal adenocarcinoma (DAC) has not yet been characterized because of its low frequency. Here, we examined the functional roles of core protein (MUC1-C) in DAC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193000
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http://dx.doi.org/10.1016/j.jss.2019.01.006DOI Listing
February 2019
1 Read

Response to Letter by Lauren L. Traill, MD: "Regarding Depression and Its Association With Better Coronary Artery Bypass Grafting Outcomes in Patients Readmitted to the Hospital".

J Surg Res 2019 Feb 8. Epub 2019 Feb 8.

Cardiovascular Outcomes Research Laboratories (CORELAB), University of California Los Angeles, Los Angeles, California; Division of Cardiac Surgery, University of California Los Angeles, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.01.014DOI Listing
February 2019

Predictors for Pouchitis After Ileal Pouch-Anal Anastomosis for Pediatric-Onset Ulcerative Colitis.

J Surg Res 2019 Feb 8;238:72-78. Epub 2019 Feb 8.

Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Background: The predictive factors for the development of pouchitis after ileal pouch-anal anastomosis (IPAA) in pediatric-onset ulcerative colitis (UC) have not been well investigated. The present study aimed to determine the predictive factors for the development of pouchitis after IPAA in the pediatric UC population.

Methods: The data from 54 patients with pediatric-onset UC who underwent IPAA in Mie University Hospital between 2000 and 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.022DOI Listing
February 2019

A Comparative Multimetric Assessment of English and Spanish Carpal Tunnel Syndrome Materials.

J Surg Res 2019 Feb 7;238:64-71. Epub 2019 Feb 7.

Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Spanish-speaking Hispanics living in the United States utilize the internet as a primary means to obtain health information. Accurate, accessible information is important for English speakers; however, it could have even greater utility for Spanish speakers who have lower health literacy levels. The aim of this study was to evaluate and compare online English and Spanish carpal tunnel surgery materials provided by using a multimetric approach. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.032DOI Listing
February 2019
1 Read

Playing the Surgical Technologist Role by Surgery Residents Improves Their Technical and Nontechnical Skills.

J Surg Res 2019 Feb 6;238:57-63. Epub 2019 Feb 6.

Department of Surgery, Veterans Affairs Boston Healthcare System (112-C), Boston, Massachusetts. Electronic address:

Background: The present study was designed to implement and evaluate an interprofessional surgical technologist-to-surgical resident training program for junior general surgery residents aimed at enhancing their operating room skills. This program would be incorporated into the general surgery educational curriculum.

Material And Methods: Under the guidance and supervision of a surgical technologist, first-year and second-year general surgery residents performed the perioperative and intraoperative tasks that are the responsibilities of the surgical technologist for 16 inguinal/umbilical hernia and 15 laparoscopic appendectomy/cholecystectomy operations performed by attending surgeons assisted by other surgical residents from June 01, 2017 until December 31, 2017. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.026DOI Listing
February 2019

Leptinemia is Associated With Peripheral Artery Disease.

J Surg Res 2019 Feb 6;238:48-56. Epub 2019 Feb 6.

Department of Surgery, University of California, San Francisco, San Francisco, California. Electronic address:

Background: Leptin, adiponectin, and resistin are in a class of hormones called adipokines that are produced by adipocytes and have been implicated in the causal pathway of atherosclerosis. We examined the association between adipokine levels and peripheral artery disease (PAD), hypothesizing that after adjusting for fat mass, leptin and resistin would be higher, whereas adiponectin would be lower, in patients with PAD.

Methods: A cross-sectional sample of 179 predominately male (97%) vascular surgery outpatients was recruited from the San Francisco Veterans Affairs Medical Center (SFVAMC). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.023DOI Listing
February 2019

Sphincter of Oddi Dysfunction After Gastric Bypass: Surgical or Endoscopic Therapy?

J Surg Res 2019 Feb 6;238:41-47. Epub 2019 Feb 6.

Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: Management of Sphincter of Oddi Dysfunction (SOD) requires advanced techniques (endoscopic retrograde cholangiopancreatography via gastrostomy [GERCP]) after Roux-en-Y gastric bypass (RYGB) for obesity. Transduodenal sphincteroplasty (TS) is also performed yet carries the risks of surgery. We hypothesized that TS would have increased morbidity and mortality but provide a more durable remission of symptoms. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.013DOI Listing
February 2019

Metastatic Profile of Colorectal Cancer: Interplay Between Primary Tumor Location and KRAS Status.

J Surg Res 2019 Feb 5. Epub 2019 Feb 5.

Division of Surgical Oncology, National Cancer Centre, Singapore. Electronic address:

Background: Mutant KRAS tumors are purported to metastasize differently than wild-type KRAS tumors. The biological heterogeneity of tumors from different parts of the colon are also reported to affect metastasis. This study aims to characterize the metastatic profile by evaluating these factors in unison. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.025DOI Listing
February 2019
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Trends and Outcomes of Synchronous Resection of Colorectal Metastasis in the Modern Era-Analysis of Targeted Hepatic NSQIP Database.

J Surg Res 2019 Feb 5;238:35-40. Epub 2019 Feb 5.

Good Samaritan General Surgery Residency Program, Cincinnati, Ohio; TriHealth Cancer Institute, Cincinnati, Ohio. Electronic address:

Background: Previous studies using the NSQIP database to study hepatectomies lacked hepatic specific variables and outcomes. We used the targeted NSQIP hepatectomy database to examine the nationwide trend and the safety profile of synchronous liver and colorectal resection compared with hepatectomy alone for colorectal liver metastasis.

Methods: The targeted NSQIP hepatectomy database from 2014 was used to study patients who underwent hepatectomy for diagnosis of adenocarcinoma of the colon and rectum. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.021DOI Listing
February 2019
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Prior Prescription Opioid Use and Its Influence on Opioid Requirements After Orthopedic Trauma.

J Surg Res 2019 Feb 5;238:29-34. Epub 2019 Feb 5.

Department of Orthopaedic Surgery, Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Prior opioid use has been shown to be associated with adverse outcomes in surgical and trauma patients. We sought to evaluate the influence of prior opioid use on prescription opioid requirements after orthopedic trauma.

Materials And Methods: This was a retrospective review of TRICARE claims (2006-2014). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.016DOI Listing
February 2019

Atrial Fibrillation After Gastrointestinal Surgery: Incidence and Associated Risk Factors.

J Surg Res 2019 Feb 5;238:23-28. Epub 2019 Feb 5.

Clinical Research Fellow, Department of General Surgery, Sheffield Teaching Hospitals, Sheffield, UK. Electronic address:

Background: Atrial fibrillation (AF) is a common dysrhythmia that can occur after major physiological stress including surgery (postoperative AF). There are few data on postoperative AF after abdominal surgery. We set out to define the incidence of de novo postoperative AF after abdominal surgery and associated risk factors. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.017DOI Listing
February 2019
2 Reads

The Impact of Pediatric Surgical Specialty Meetings: A 5-year Analysis of Presented Abstracts.

J Surg Res 2019 Feb 2;238:16-22. Epub 2019 Feb 2.

Yale School of Medicine, Department of Surgery, Section of Pediatric Surgery, New Haven, Connecticut. Electronic address:

Background: Abstracts presented at the American Academy of Pediatrics Section on Surgery (AAP) and American Pediatric Surgical Association (APSA) meetings can be taken as a reasonable representation of academic activity in pediatric surgery. We sought to assess ongoing trends in pediatric surgical research by analyzing the scientific content of each association's yearly meeting.

Methods: Abstracts presented at AAP and APSA between 2009 and 2013 were identified from the final printed programs (n = 910). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804183082
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http://dx.doi.org/10.1016/j.jss.2018.11.034DOI Listing
February 2019
2 Reads

Association Between Sarcopenia and AFP Level in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.

J Surg Res 2019 Feb 2;238:10-15. Epub 2019 Feb 2.

Department of Radiology, University of Kentucky College of Medicine, Lexington, Kentucky.

Background: Sarcopenia is one of the most common complications of cirrhosis. Liver transplantation (LT) is the treatment of choice for patients with early-stage hepatocellular carcinoma (HCC) that are unsuitable for resection.

Methods: We performed a retrospective analysis of 163 patients transplanted at our institution with HCC from 1998 to 2016. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.007DOI Listing
February 2019
2 Reads

Is the Human Brain Capable of Controlling Seven Degrees of Freedom?

J Surg Res 2019 Feb 2;238:1-9. Epub 2019 Feb 2.

Department of Neurosurgery, Ghent University Hospital, Ghent, Belgium.

Background: Conventional rigid laparoscopic instruments offer five degrees of freedom (DOF). Robotic instruments add two independent DOFs allowing unconstrained directional steering. Several nonrobotic instruments have been developed with the additional DOFs, but with these devices, surgeon's wrist movements are not intuitively transmitted into tip movements. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.005DOI Listing
February 2019
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Depression and Its Association With Better Coronary Artery Bypass Grafting Outcomes in Readmitted Patients.

Authors:
Lauren L Traill

J Surg Res 2019 Jan 31. Epub 2019 Jan 31.

Department of Anesthesiology, Warren Alpert Medical School, Brown University, Providence, Rhode Island. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.01.002DOI Listing
January 2019

Resorbable Synthetic Meshes for Abdominal Wall Defects in Preclinical Setting: A Literature Review.

J Surg Res 2019 Jan 30;237:67-75. Epub 2019 Jan 30.

Erasmus University Medical Center Rotterdam, Department of Surgery, The Netherlands.

Background: Prosthetic materials for the repair of abdominal wall defects have been studied extensively to improve outcome. A new approach can be the use of a slowly resorbable synthetic mesh, which aims to combine advantages of both synthetic and biological meshes. The objective of this review is to give an overview of the physicochemical characteristics and biomechanical, histological, and macroscopic outcome (recurrence, adhesion formation) of the use of resorbable synthetic meshes, for treatment and prevention of abdominal wall hernias, based on experimental studies. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.054DOI Listing
January 2019
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Does Age Affect Surgical Outcomes After Ileal pouch-Anal Anastomosis in Children?

J Surg Res 2019 Jan 30;237:61-66. Epub 2019 Jan 30.

Department of Pediatric Surgery, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pediatric Surgery, Children's Medical Center, Dallas, Texas. Electronic address:

Background: Younger children are referred for surgical intervention in the treatment of ulcerative colitis (UC) and familial adenomatous polyposis (FAP). Outcome data in this population after a laparoscopic restorative proctocolectomy and Ileal pouch-anal anastomosis (LRS-IPAA) are limited. We reviewed our experience to determine if younger children would have similar functional outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193000
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http://dx.doi.org/10.1016/j.jss.2019.01.004DOI Listing
January 2019
2 Reads

Dwarfs and Giants of Parathyroid Adenomas-No Difference in Outcome After Parathyroidectomy.

J Surg Res 2019 Jan 25;237:56-60. Epub 2019 Jan 25.

Department of Endocrine Surgery, Churchill Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Backgroud: This study compares the outcome of parathyroidectomy for primary hyperparathyroidism (PHPT) in patients whose adenomas' weights were at the extremes of the distribution curve. As the size of parathyroid adenomas influences the success rate of localization studies for PHPT, it is possible that a difference in cure rate could be observed between subgroups of patients.

Materials And Methods: Data were retrieved from a prospective database maintained in a large university hospital. Read More

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http://dx.doi.org/10.1016/j.jss.2018.12.021DOI Listing
January 2019
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Feasibility and Outcomes of Femoral Vein Harvest for Dialysis Access and Arterial Reconstruction.

J Surg Res 2019 Jan 24;237:50-55. Epub 2019 Jan 24.

Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Johns Hopkins Medical Institutes, Baltimore, Maryland. Electronic address:

Background: We describe the feasibility and long-term outcomes of using femoral vein (FV) for arteriovenous fistula (AVF) and lower extremity bypass (LEB) creation.

Methods: All patients undergoing AVF or LEB using autogenous FV by a single surgeon (April 2006 to September 2013) were reviewed. Perioperative (30-d) complications and long-term outcomes are described. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.036DOI Listing
January 2019
2 Reads

National Trends in Multimodality Therapy for Locally Advanced Gastric Cancer.

J Surg Res 2019 Jan 23;237:41-49. Epub 2019 Jan 23.

Center for Innovations in Quality, Effectiveness, and Safety, Michael E. DeBakey VA Medical Center, Houston, Texas; Division of Surgical Oncology, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Background: Multimodality therapy (MMT) is recommended for patients with resectable gastric cancer, but no single approach has been established as standard. Little is presently known about current national practice patterns and sequencing of MMT.

Methods: Retrospective cohort study of patients with gastric cancer aged 18 to 80 y in the National Cancer Database (2006-2014) with ≥T2 and/or node-positive disease (i. Read More

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http://dx.doi.org/10.1016/j.jss.2018.12.026DOI Listing
January 2019
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Evaluation of a Pilot Perioperative Smoking Cessation Program: A Pre-Post Study.

J Surg Res 2019 Jan 18;237:30-40. Epub 2019 Jan 18.

San Francisco Medical Center, Kaiser Permanente Northern California, San Francisco, California.

Background: Surgical clinic and perioperative settings are critical touchpoints for treating smoking, yet health care systems have not typically prioritized smoking cessation among surgical patients. We evaluated the implementation of a pilot smoking cessation intervention integrated into standard perioperative care.

Materials And Methods: English-speaking adult smokers undergoing elective surgery in Kaiser Permanente San Francisco before (2015) and after (2016-2017) the implementation of a smoking cessation intervention were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804183087
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http://dx.doi.org/10.1016/j.jss.2018.12.022DOI Listing
January 2019
12 Reads

Preoperative Exercise Rehabilitation in Cardiac and Vascular Interventions.

J Surg Res 2019 Jan 9;237:3-11. Epub 2019 Jan 9.

Division of Vascular Surgery, Department of Surgery, McGill University, Montreal, Quebec, Canada. Electronic address:

Background: Exercise-based interventions have become part of the standard of care in rehabilitation programs for cardiovascular risk reduction and the promotion of a healthy lifestyle. The systematic review describes the current state of knowledge of the effects of preoperative exercise training (prehabilitation) on perioperative clinical outcomes in patients undergoing cardiac and vascular interventions.

Methods: Studies were systematically searched within 14 databases from inception to October 2016. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.042DOI Listing
January 2019

The Embryonic Stem Cell-Specific Transcription Factor ZFP57 Promotes Liver Metastasis of Colorectal Cancer.

J Surg Res 2019 Jan 21;237:22-29. Epub 2019 Jan 21.

Department of Stem Cell Biology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan; Laboratory of Molecular and Biochemical Research, Research Support Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Background: The embryonic stem cell-specific transcription factor, ZFP57, has been shown to play an important role in tumor formation. In this study, we examined if ZFP57 is involved in colorectal cancer metastasis.

Materials And Methods: First, we used colorectal cancer cell lines to perform in vivo metastatic experiments with nude mice. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.014DOI Listing
January 2019
1 Read

Semiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis.

J Surg Res 2019 Jan 14;237:12-21. Epub 2019 Jan 14.

Departments of Gastrointestinal Oncology, H. Lee Moffitt Cancer and Research Institute, Tampa, Florida. Electronic address:

Background: The obesity epidemic has prompted the need to better understand the impact of adipose tissue on human pathophysiology. However, accurate, efficient, and replicable models of quantifying adiposity have yet to be developed and clinically implemented. We propose a novel semiautomated radiologic method of measuring the visceral fat area (VFA) using computed tomography scan analysis. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.027DOI Listing
January 2019

Potential Use of Desmopressin During Hepatic Resection for Colorectal Liver Metastases.

J Surg Res 2019 Jan 9;237:1-2. Epub 2019 Jan 9.

Laboratory of Molecular Oncology, National University of Quilmes, Bernal, Buenos Aires, Argentina; National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2018.12.010DOI Listing
January 2019
1 Read

National Cancer Institute Centers and Society of Surgical Oncology Cancer Research Synergy.

J Surg Res 2018 Dec 7;236:92-100. Epub 2018 Dec 7.

Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: The objective of this study was to examine the influence of Surgical Society Oncology (SSO) membership and National Cancer Institute (NCI) status on the academic output of surgical faculty.

Methods: NCI cancer program status for each department of surgery was identified with publically available data, whereas SSO membership was determined for every faculty member. Academic output measures such as NIH funding, publications, and citations were analyzed in subsets by the type of cancer center (NCI comprehensive cancer center [CCC]; NCI cancer center [NCICC]; and non-NCI center) and SSO membership status. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.009DOI Listing
December 2018

The Role of Completion Lymphadenectomy in Positive Regional Lymph Nodes in Melanoma: A Meta-analysis.

J Surg Res 2018 Dec 7;236:83-91. Epub 2018 Dec 7.

Division of Surgical Oncology, Jackson Memorial Hospital and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.

Background: The optimal management of melanoma with positive sentinel lymph node (SLN) remains unclear. Completion lymph node dissection (CLND) only yields additional positive non-SLN in 20% of cases and its benefits on survival remains debatable.

Methods: An online database search of Medline was performed; key bibliographies were reviewed. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.015DOI Listing
December 2018
1 Read
1.936 Impact Factor

Interfacility Transfer is Associated With Lower Mortality in Undertriaged Gunshot Wound Patients.

J Surg Res 2018 Dec 7;236:74-82. Epub 2018 Dec 7.

Department of Urology, New York University Langone Hospital - Brooklyn, Brooklyn, New York.

Background: Treatment at a Level I trauma center yields better outcomes for patients with moderate-to-severe injury as compared with treatment in nontrauma centers. We examined the association between interfacility transfer to a level I or II trauma center and mortality for gunshot wound patients, among patients initially transported to a lower level or undesignated facility.

Materials And Methods: This retrospective cohort study included all patients from the National Trauma Data Bank (2010-2015) with firearm as the external cause of injury, who met CDC criteria for emergency medical services triage to a higher level (American College of Surgeons [ACS] Level II or above) trauma center. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.011DOI Listing
December 2018
1 Read

Predicting Pathology From Imaging in Children Undergoing Resection of Congenital Lung Lesions.

J Surg Res 2018 Dec 7;236:68-73. Epub 2018 Dec 7.

Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California. Electronic address:

Background: Prenatal magnetic resonance imaging (MRI) is increasingly obtained to define congenital lung lesions (CLL) for surgical management. Postnatal, preoperative computed tomography (CT) provides further clarity at the cost of radiation. Depending on the lesion identified, the indication for resection remains controversial. Read More

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http://dx.doi.org/10.1016/j.jss.2018.10.042DOI Listing
December 2018
1 Read

Laparoscopic Magnetic Compression Biliojejunostomy: A Preliminary Clinical Study.

J Surg Res 2018 Dec 7;236:60-67. Epub 2018 Dec 7.

Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China; Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center, Xi'an, Shaanxi Province, China. Electronic address:

Background: Magnetic compression anastomosis is a feasible and effective method for bilioenteric anastomosis (BEA) in animal model. The objective of the present study was to report our initial clinical experience in laparoscopically magnetic compression bilioenteric anastomosis (LMC-BEA).

Methods: Patients with obstructive jaundice who were candidates for LMC-BEA were prospectively enrolled from 2013 to 2015. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.010DOI Listing
December 2018

Risk Factors for Undergoing Elective Abdominal Contouring Surgery Shortly After Hospitalization.

J Surg Res 2018 Dec 6;236:51-59. Epub 2018 Dec 6.

Department of Surgery, Section of Plastic Surgery, Assistant Dean for Faculty Affairs, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address:

Background: Having posthospital syndrome (PHS) at the time of an elective surgery increases the risk of postoperative adverse outcomes. The purpose of this article was to identify incidence and risk factors for having PHS at the time of abdominal contouring surgeries.

Methods: Insurance claims from the Truven MarketScan Databases were used to identify patients who underwent outpatient abdominoplasty, liposuction, or panniculectomy between April 2010 and August 2015. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.013DOI Listing
December 2018
1 Read

Defining Massive Transfusion in Civilian Pediatric Trauma With Traumatic Brain Injury.

J Surg Res 2018 Dec 4;236:44-50. Epub 2018 Dec 4.

Department of Pediatric Surgery, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas. Electronic address:

Background: The purpose of this study was to identify an optimal definition of massive transfusion in civilian pediatric trauma with severe traumatic brain injury (TBI) METHODS: Severely injured children (age ≤18 y) with severe TBI in the Trauma Quality Improvement Program research data sets 2015-2016 that received blood products were identified. Data were analyzed using descriptive statistics, Wilcoxon rank-sum, chi-square, and logistic regression. Continuous variables are presented as median (interquartile range). Read More

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http://dx.doi.org/10.1016/j.jss.2018.10.053DOI Listing
December 2018
1 Read
1.936 Impact Factor

Treatment of Primary Aldosteronism Reduces the Probability of Obstructive Sleep Apnea.

J Surg Res 2018 Dec 4;236:37-43. Epub 2018 Dec 4.

Department of Surgery, Endocrine Surgery Section, University of California, San Francisco, San Francisco, California. Electronic address:

Background: Aldosterone excess is hypothesized to worsen obstructive sleep apnea (OSA) symptoms by promoting peripharyngeal edema. However, the extent to which primary aldosteronism (PA), hypertension, and body mass index (BMI) influence OSA pathogenesis remains unclear.

Methods: We conducted a cross-sectional study of PA patients from our endocrine database to retrospectively evaluate OSA probability before and after adrenalectomy or medical management of PA. Read More

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http://dx.doi.org/10.1016/j.jss.2018.10.040DOI Listing
December 2018
4 Reads

The Impact of Ethnicity on Metabolic Outcomes after Bariatric Surgery.

J Surg Res 2019 Jan 4;236:345-351. Epub 2019 Jan 4.

Department of Surgery, Bariatric and Minimally Invasive Surgery, Stanford School of Medicine, Stanford, California. Electronic address:

Background: Previous studies have demonstrated that ethnic minority patients experience significant metabolic improvements after bariatric surgery but less so than non-Hispanic whites. Previous research has primarily investigated differences between non-Hispanic white and black patients. Thus, there remains a need to assess differences in diabetic outcomes among other ethnic groups, including Hispanic and Asian patient populations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804183069
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http://dx.doi.org/10.1016/j.jss.2018.09.061DOI Listing
January 2019
4 Reads

Effects of Colorectal Surgery Classification on Reported Postoperative Surgical Site Infections.

J Surg Res 2019 Jan 4;236:340-344. Epub 2019 Jan 4.

Department of Surgery, Section of Colorectal Surgery, Stanford University School of Medicine, Stanford, California.

Background: Current procedural terminology (CPT) for colon and rectal surgery lacks procedural granularity and misclassification rates are unknown. However, they are used in performance measurement, for example, in surgical site infection (SSI). The objective of this study was to determine whether American College of Surgeons National Surgical Quality Improvement Program (NSQIP) abstraction methods accurately classify types of colorectal operations and, by extension, reported SSI rates. Read More

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http://dx.doi.org/10.1016/j.jss.2018.12.005DOI Listing
January 2019
2 Reads

Evidence versus Practice in Early Drain Removal After Pancreatectomy.

J Surg Res 2019 Jan 4;236:332-339. Epub 2019 Jan 4.

Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Houston, TX. Electronic address:

Background: Early drain removal when postoperative day (POD) one drain fluid amylase (DFA) was ≤5000 U/L reduced complications in a previous randomized controlled trial. We hypothesized that most surgeons continue to remove drains late and this is associated with inferior outcomes.

Methods: We assessed the practice of surgeons in a prospectively maintained pancreas surgery registry to determine the association between timing of drain removal with demographics, comorbidities, and complications. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.048DOI Listing
January 2019
1 Read

Orally Dosed Citalopram Stimulates Small Intestinal Mucosal Growth.

J Surg Res 2019 Jan 3;236:326-331. Epub 2019 Jan 3.

Department of Surgery, Section of Pediatric Surgery, Yale School of Medicine, New Haven, Connecticut. Electronic address:

Background: Parenterally administered selective serotonin reuptake inhibitors, such as citalopram, increase intestinal mucosal absorptive surface by day 7 of treatment. We hypothesized that enteral citalopram would also induce intestinal mucosal growth, thus allowing for therapy with an oral agent.

Materials And Methods: Following a habituation period, C57BL/6 mice received peanut butter pellets containing 10, 50, or 100 mg/kg/d citalopram for 7 d (n = 5); or 25 mg/kg/d citalopram for 14 (n = 3) or 21 (n = 5) d; or plain peanut butter pellets for 7 (n = 2), 14 (n = 2), or 21 d (n = 3). Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.033DOI Listing
January 2019

The Charlson Index is Insufficient to Control for Comorbidities in a National Trauma Registry.

J Surg Res 2018 Dec 31;236:319-325. Epub 2018 Dec 31.

Department of Urology, New York University Langone Hospital-Brooklyn, Brooklyn, New York.

Background: The Charlson Comorbidity Index (CCI) is frequently used to control for confounding by comorbidities in observational studies, but its performance as such has not been studied. We evaluated the performance of CCI and an alternative summary method, logistic principal component analysis (LPCA), to adjust for comorbidities, using as an example the association between insurance and mortality.

Materials And Methods: Using all admissions in the National Trauma Data Bank 2010-2015, we extracted mortality, payment method, and 36 International Classification of Disease, Ninth Revision-derived comorbidities. Read More

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http://dx.doi.org/10.1016/j.jss.2018.07.072DOI Listing
December 2018
2 Reads

Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway.

J Surg Res 2018 Dec 28;236:311-318. Epub 2018 Dec 28.

Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address:

Background: Despite melatonin treatment diminishes inflammatory mediator production and improves organ injury after acute pancreatitis (AP), the mechanisms remain unknown. This study explores whether melatonin improves liver damage after AP through protein kinase B (Akt)-dependent peroxisome proliferator activated receptor (PPAR)-γ pathway.

Methods: Male Sprague-Dawley rats were subjected to cerulein-induced AP. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.056DOI Listing
December 2018
2 Reads
1.936 Impact Factor

Slow as Compared to Rapid Rewarming After Mild Hypothermia Improves Survival in Experimental Shock.

J Surg Res 2018 Dec 28;236:300-310. Epub 2018 Dec 28.

Institute of Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Background: Accidental hypothermia following trauma is an independent risk factor for mortality. However, in most experimental studies, hypothermia clearly improves outcome. We hypothesized that slow rewarming is beneficial over rapid rewarming following mild hypothermia in a rodent model of hemorrhagic shock. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.057DOI Listing
December 2018
1 Read

Variation in Physician-Specific Episode Payments for Major Cancer Surgery and Implications for the Merit-Based Incentive Program.

J Surg Res 2018 Dec 4;236:30-36. Epub 2018 Dec 4.

Dow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan.

Background: Nearly 1.5 million clinicians in the United States will be affected by Centers for Medicare and Medicaid Services' (CMS) new payment program, the Merit-based Incentive Program (MIPS), where clinicians will be penalized or rewarded based on the health care expenditures of their patients. We therefore examined expenditures for major cancer surgery to understand physician-specific variation in episode payments. Read More

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http://dx.doi.org/10.1016/j.jss.2018.09.073DOI Listing
December 2018

Long-term Outcomes of Immunohistochemically Defined Subtypes of Breast Cancer Less Than or Equal to 2 cm After Breast-Conserving Surgery.

J Surg Res 2018 Dec 27;236:288-299. Epub 2018 Dec 27.

Department of General Surgery II, University Hospital ASST Spedali Civili, Brescia, Italy.

Background: Molecular subtype predicts the prognosis of early-stage breast cancer patients. We assessed the long-term outcomes of breast cancer ≤2 cm treated with breast-conserving surgery (BCS) and stratified according to an immunohistochemically (IHC)-based subtype definition.

Methods: This retrospective study was conducted from a prospectively collected database. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.028DOI Listing
December 2018
1 Read

miR-145-5p Suppresses Breast Cancer Progression by Inhibiting SOX2.

J Surg Res 2018 Dec 27;236:278-287. Epub 2018 Dec 27.

Department of Breast Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China. Electronic address:

Background: In this study, we aimed to investigate the expression and clinical significance of miR-145-5p and its tumor-suppressive effect in breast cancer patients.

Methods: We used luciferase reporter assay, real-time quantitative reverse transcription polymerase chain reaction and Western blot to identify sex-determining region Y-box2 (SOX2) as the target gene of miR-145-5p. Their expression levels in breast cancer tissues (n = 122) were detected by real-time quantitative polymerase chain reaction. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.030DOI Listing
December 2018

Mixed Histology Is a Risk Factor for Lymph Node Metastasis in Early Gastric Cancer.

J Surg Res 2018 Dec 27;236:271-277. Epub 2018 Dec 27.

Division of Gastrointestinal Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background: The risk factors of lymph node (LN) metastasis are important factors to consider in endoscopic submucosal dissection in early gastric cancer (EGC). The aim of the study was to identify the correlation between mixed histology and LN metastasis in EGC.

Methods: A total of 1645 patients who underwent curative radical gastrectomy for EGC were divided into three groups (pure differentiated [pure D], mixed, and pure undifferentiated [pure UD]) according to histologic type. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.055DOI Listing
December 2018

Underreporting of Veress Needle Injuries: Comparing Direct Observation and Chart Review Methods.

J Surg Res 2018 Dec 24;236:266-270. Epub 2018 Dec 24.

International Centre for Surgical Safety, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Background: Adverse events in surgery occur frequently, increase likelihood of postoperative morbidity, and mostly take place in the operating rooms. Several surgeons have advocated for learning from adverse events and near misses to help improve patient safety. To do so, one must first understand how to accurately identify and report intraoperative events. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.039DOI Listing
December 2018
1 Read

Radiation With Neoadjuvant Chemotherapy Does Not Improve Outcomes in Esophageal Squamous Cell Cancer.

J Surg Res 2018 Dec 24;236:259-265. Epub 2018 Dec 24.

Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, New York. Electronic address:

Background: Neoadjuvant treatment improves survival for patients undergoing esophagectomy for esophageal cancer. Recent evidence suggests that neoadjuvant chemoradiation offers no advantage over chemotherapy alone before surgical resection for adenocarcinoma histology. We sought to examine if this applies to patients with squamous cell histology. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.052DOI Listing
December 2018
1.936 Impact Factor

Large Animal Models of Proximal Aortic Balloon Occlusion in Traumatic Hemorrhage: Review and Identification of Knowledge Gaps Relevant to Expanded Use.

J Surg Res 2018 Dec 21;236:247-258. Epub 2018 Dec 21.

Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Surgery, Madigan Army Medical Center, Fort Lewis, Washington.

Background: The aim of this study was to review and summarize the large animal data on resuscitative endovascular balloon occlusion of the aorta (REBOA) for traumatic hemorrhage and identify knowledge gaps pertinent to the proposed broader use of the technique in prehospital situations.

Methods: A review of published large animal models of traumatic hemorrhage incorporating REBOA with a primary outcome of the effect of aortic occlusion was performed. Data were collected on experimental protocols, hemodynamic effects, resuscitation requirements, mortality, metabolic and tissue consequences of induced ischemia-reperfusion, and effects on hemorrhage volume and other injuries. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.038DOI Listing
December 2018

The Impact of Ergonomics on Recruitment to Surgical Fields: A Multi-institutional Survey Study.

J Surg Res 2018 Dec 20;236:238-246. Epub 2018 Dec 20.

Division of Plastic, Maxillofacial & Oral Surgery, Duke University Medical Center, Durham, North Carolina. Electronic address:

Background: Awareness of ergonomics in surgery is growing, but whether musculoskeletal (MSK) injuries in surgery influence trainee career choices remains unknown. This study aimed to characterize medical students' MSK pain during surgical rotations and determine whether ergonomics influence student interest in surgical fields.

Methods: An online survey was administered to medical students in North Carolina. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.035DOI Listing
December 2018

Effect of Alprostadil on Colorectal Anastomoses Under Relative Ischemia.

J Surg Res 2018 Dec 20;236:230-237. Epub 2018 Dec 20.

Department of General and Digestive Surgery, Valme University Hospital, Seville, Spain; Department of Surgery, University of Seville, Seville, Spain.

Background: Anastomotic leak after colorectal surgery, which remains a serious clinical problem that causes augmented morbidity and mortality, is usually favored by ischemia. The aim of this study was to determine whether alprostadil may improve anastomotic wound healing under ischemic condition.

Methods: Ninety-three adult Wistar rats were randomized into three groups: control, ischemia (by devascularization along the first 2 cm at each anastomotic end), and ischemia plus alprostadil. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.046DOI Listing
December 2018
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Is There a Need for Platelet Transfusion After TBI in Patients on P2Y12 Inhibitors?

J Surg Res 2018 Dec 20;236:224-229. Epub 2018 Dec 20.

Division of Trauma, Department of Surgery, Critical Care, Emergency Surgery, and Burns, University of Arizona, Tucson, Arizona. Electronic address:

Background: A significant portion of patients sustaining traumatic brain injury (TBI) are on antiplatelet medications. The reversal of P2Y12 agents after intracranial hemorrhage (ICH) remains unclear. The aim of our study is to evaluate outcomes after TBI in patients who are on preinjury P2Y12 inhibitors and received a platelet transfusion. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.050DOI Listing
December 2018