2,200 results match your criteria Journal of Reproductive Immunology [Journal]


Macrophages infiltrating endometriosis-like lesions exhibit progressive phenotype changes in a heterologous mouse model.

J Reprod Immunol 2019 Jan 25;132:1-8. Epub 2019 Jan 25.

Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia; The Women's and Children's Hospital, Department of Obstetrics and Gynaecology, North Adelaide, SA 5006, Australia. Electronic address:

Endometriotic lesion development involves complex interactions between endometrial tissue, the peritoneum and immune cells. Macrophages are essential in this process; however their precise roles are not defined. To investigate whether infiltrating macrophages acquire functionally different phenotypes during lesion development, human endometrial tissues were grafted into immunodeficient mice expressing macrophage-specific green fluorescent protein (GFP). Read More

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http://dx.doi.org/10.1016/j.jri.2019.01.002DOI Listing
January 2019

Changes of γδT cell subtypes during pregnancy and their influences in spontaneous abortion.

J Reprod Immunol 2019 Feb 25;131:57-62. Epub 2019 Jan 25.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China; Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, 200011, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200032, China; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Shanghai 200032, China. Electronic address:

A successful pregnancy is a complicated process that involves the precisely timed regulation of endocrine as well as immune system. Despite increasing knowledge about immunology in gestation, the studies of immune cells in endometrium and decidua are still fragmented. Dynamic data is lacking on the transition of pre-pregnancy endometrial lymphocytes to initial pregnancy states as well as to second/third-trimester status. Read More

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http://dx.doi.org/10.1016/j.jri.2019.01.003DOI Listing
February 2019
1 Read

Intrauterine administration of autologous peripheral blood mononuclear cells in patients with recurrent implantation failure: A systematic review and meta-analysis.

J Reprod Immunol 2019 Feb 15;131:50-56. Epub 2019 Jan 15.

Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Electronic address:

Intrauterine administration of autologous peripheral blood mononuclear cells (PBMC) has been proposed to improve implantation rates in women with recurrent implantation failure (RIF). The objective of this study was to evaluate whether intrauterine administration of PBMC improves clinical pregnancy and live birth in couples with RIF. Various databases were searched including Medline, Embase, Scopus, Web of Science and Cochrane Central Register of Controlled Trials up to April 2018. Read More

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http://dx.doi.org/10.1016/j.jri.2019.01.001DOI Listing
February 2019

Pro- and anti-inflammatory effects of sulforaphane on placental cytokine production.

J Reprod Immunol 2019 Feb 29;131:44-49. Epub 2018 Dec 29.

Department of Biomedical Research, Winthrop University Hospital, Mineola, NY, United States; Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, NY, United States. Electronic address:

Placental inflammation increases the risk of adverse pregnancy outcomes and possibly neurodevelopmental disorders in the offspring. Previous research suggests it may be possible to modulate the placental immune response to bacteria to favor an anti-inflammatory phenotype with dietary factors. Sulforaphane (SFN) is a dietary supplement with known anti-inflammatory activities, however, its effects on placental cytokine production are unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650378183022
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http://dx.doi.org/10.1016/j.jri.2018.12.003DOI Listing
February 2019
3 Reads

Involvement of ILR4α and TLR4 in miscarriages.

J Reprod Immunol 2019 Feb 8;131:36-43. Epub 2019 Jan 8.

Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Background: The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.

Patients And Methods: Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16)). TLR4 and IL4Rα were analyzed by immunohistochemistry, immunofluorescence and real time PCR. Read More

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http://dx.doi.org/10.1016/j.jri.2018.12.001DOI Listing
February 2019
2 Reads
2.815 Impact Factor

Effect of adoptive transfer of CD4CD25Foxp3 Treg induced by trichostatin A on the prevention of spontaneous abortion.

J Reprod Immunol 2019 Feb 26;131:30-35. Epub 2018 Dec 26.

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. Electronic address:

Objective: To investigate whether epigenetic modification of CD4CD25 T-cells in vitro can make up for the inadequacy of CD4CD25Foxp3 Treg in animal model of spontaneous abortion and prevent immune response-mediated spontaneous abortion.

Methods: Trichostatin A (TSA) was applied to inhibit histone deacetylases (HDACs) and thereby to epigenetically modify the special location of Foxp3 gene in CD4CD25 T-cells of CBA/J mice. The expressions of CD25, Foxp3, CTLA-4 and PD-1 of CD4 T cells isolated from spleen of mice were characterized by flow cytometric analysis. Read More

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http://dx.doi.org/10.1016/j.jri.2018.12.002DOI Listing
February 2019
12 Reads

T cell Subsets in Peripheral Blood of Women with Recurrent Implantation Failure.

J Reprod Immunol 2019 Feb 8;131:21-29. Epub 2018 Nov 8.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

The objective of this study was to determine whether there are any differences in the T cell composition and the expression of specific factors (i.e., IRF4, TBX21, GATA3, and GITR) of T cells between women with Repeated Implantation Failure (RIF) and fertile women. Read More

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http://dx.doi.org/10.1016/j.jri.2018.11.002DOI Listing
February 2019
11 Reads
2.820 Impact Factor

Antibacterial defense and sperm quality in boar ejaculates.

J Reprod Immunol 2019 Feb 3;131:13-20. Epub 2018 Nov 3.

Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Str. 17, D-10315 Berlin, Germany.

The aim of the present study was to characterize the lysozyme concentration and the bacterial killing activity (BKA) of boar seminal plasma against E. coli and S. aureus in 119 fertile Pietrain boars (aged: 18. Read More

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http://dx.doi.org/10.1016/j.jri.2018.11.001DOI Listing
February 2019
8 Reads

Progesterone treatment enhances the expansion of placental immature myeloid cells in a mouse model of premature labor.

J Reprod Immunol 2019 Feb 26;131:7-12. Epub 2018 Oct 26.

Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel; Rappaport faculty of Medicine, Techinon-Isarel Institute of Technology, Israel. Electronic address:

Introduction: immature-myeloid cells (IMCs) are proangiogenic bone marrow (BM)-derived cells that normally differentiate into inflammatory cells such as neutrophils, monocytes and dendritic cells (DCs). We characterized placental IMCs comparing their gene expression and subpopulations to tumor IMCs, and tested our hypothesis that progesterone that inhibits preterm labor, may affect their abundance and differentiation.

Methods: differences between IMC-subpopulations in subcutaneous tumors versus placentas in C57BL/6 or ICR (CD-1) mice were analyzed by flow cytometry and gene expression was detected by microarrays. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650378183022
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http://dx.doi.org/10.1016/j.jri.2018.10.003DOI Listing
February 2019
14 Reads

The effect of prednisolone on endometrial uterine NK cell concentrations and pregnancy outcome in women with reproductive failure. A retrospective cohort study.

J Reprod Immunol 2019 Feb 25;131:1-6. Epub 2018 Oct 25.

The Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield and Sheffield Teaching Hospitals, Sheffield, UK. Electronic address:

This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment. 136 women diagnosed with RRF who had a timed midluteal endometrial biopsy taken for uNK cell analysis were included. Women with high uNK cell concentrations (n = 45) were treated with prednisolone (10 mg/day) for one month, after which a second biopsy was taken for repeat uNK cell analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650378183016
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http://dx.doi.org/10.1016/j.jri.2018.10.001DOI Listing
February 2019
2 Reads

Inflammation in reproduction, pregnancy and development.

J Reprod Immunol 2018 Nov 27;130:23-24. Epub 2018 Sep 27.

Hudson Institute of Medical Research, Melbourne, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S01650378183031
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http://dx.doi.org/10.1016/j.jri.2018.09.051DOI Listing
November 2018
14 Reads

Intralipid® may represent a new hope for patients with reproductive failures and simultaneously an over-immune endometrial activation.

J Reprod Immunol 2018 Nov 24;130:18-22. Epub 2018 Sep 24.

Institut National de Santé et de Recherche Médicale, INSERM UMR-976, Saint-Louis Hospital, Research Center, 1 Avenue Claude Vellefaux, 75010, Paris, France.

Problem: Continuous failures to achieve a pregnancy despite effective embryo transfers is extremely distressing for couples. In consequence, many adjuvant therapies to IVF have been proposed to achieve an "ideal" immune environment. We here focus on Intralipid® therapy (IL) reported to have immunosuppressive properties on NK cells. Read More

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http://dx.doi.org/10.1016/j.jri.2018.09.050DOI Listing
November 2018
1 Read

Retraction notice to "Heat shock protein 27 expression is spatially distributed in human placenta and selectively regulated during preeclampsia." [JRI 101-102C (2014) 89 - 95.

J Reprod Immunol 2018 09;129:68

University of Glasgow, Institute of Medical Genetics, Yorkhill Hospital, Glasgow G38SJ, UK.

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http://dx.doi.org/10.1016/j.jri.2018.08.001DOI Listing
September 2018

Inflammatory markers in human follicular fluid correlate with lipid levels and Body Mass Index.

J Reprod Immunol 2018 Nov 22;130:25-29. Epub 2018 Aug 22.

Robinson Research Institute, School of Medicine, The University of Adelaide, Adelaide, SA, 5005, Australia. Electronic address:

The detrimental consequences of obesity on female fertility are well known, but the functional changes that occur in the ovary in response to elevated BMI are not clear. Obesity induces multiple components of a systemic inflammatory state that is a key pathway by which it initiates tissue dysfunction in adipose, liver and muscle; however whether obesity induces similar inflammatory changes in the ovary has not been fully investigated. This is important to understand because it is increasingly clear that obesity at conception impacts not only pregnancy rates but also influences pre-implantation embryo development. Read More

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http://dx.doi.org/10.1016/j.jri.2018.08.005DOI Listing
November 2018
5 Reads

Human pregnancy is accompanied by modifications in B cell development and immunoglobulin profile.

J Reprod Immunol 2018 Sep 10;129:40-47. Epub 2018 Jul 10.

Research Laboratory, Department of Obstetrics and Gynecology, University of Greifswald, Greifswald, Germany; Laboratory for Immunology of Pregnancy, Center for Pharmacological and Botanical Studies (CEFYBO-CONICET- UBA), Paraguay 2155 Floor 17(th), Buenos Aires C1121ABG, Argentina; Institute of Health Sciences, National University Arturo Jauretche, Buenos Aires, Argentina. Electronic address:

Though human pregnancy success has been classically linked with a shift into a Th2 immunoglobulin producing cell response, a clear picture concerning B cell development and immunoglobulin profile during human pregnancy is missing. We analyzed in this work the dynamic of different B cell populations in peripheral blood of pregnant women on the first, second and third trimester of pregnancy. As control, age-matched non-pregnant fertile women were included. Read More

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http://dx.doi.org/10.1016/j.jri.2018.07.003DOI Listing
September 2018
8 Reads

The two-sided role of the vaginal microbiome in Chlamydia trachomatis and Mycoplasma genitalium pathogenesis.

J Reprod Immunol 2018 Nov 22;130:11-17. Epub 2018 Aug 22.

Laboratory of Immunogenetics, Department Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands; Tubascan, Spin-Off at the Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.

Sexually transmitted infections (STI) can have major consequences for the reproductive health of women. Mycoplasma genitalium is a STI that is not as well studied but causes pelvic inflammatory disease (PID) among other complications. Another well-known STI is Chlamydia trachomatis, notorious for its capability to cause infertility. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650378183004
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http://dx.doi.org/10.1016/j.jri.2018.08.006DOI Listing
November 2018
18 Reads

Local and systemic levels of cytokines and danger signals in endometriosis-affected women.

J Reprod Immunol 2018 Nov 25;130:7-10. Epub 2018 Jul 25.

Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. Electronic address:

Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammation is linked to the severity of the disease. Read More

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http://dx.doi.org/10.1016/j.jri.2018.07.006DOI Listing
November 2018
14 Reads

Killer-cell immunoglobulin-like receptors associated with polycystic ovary syndrome.

J Reprod Immunol 2018 Nov 4;130:1-6. Epub 2018 Aug 4.

Postgraduate Program in Biosciences and Physiopathology at the State University of Maringá, Paraná, Brazil; Laboratory of Immunogenetics, State University of Maringá, Paraná, Brazil. Electronic address:

Polycystic ovary syndrome (PCOS) affects the endocrine system and is associated with low-grade inflammation. Natural killer (NK) cells are involved in the defense of the female reproductive tract, folliculogenesis, ovulation and the menstrual cycle. The killer-cell immunoglobulin-like receptors (KIR) on the surface of NK cells modulate the activation and function of these cells after interacting with human leukocyte antigen (HLA) class I ligands. Read More

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http://dx.doi.org/10.1016/j.jri.2018.08.003DOI Listing
November 2018
18 Reads

High Body Mass Index is associated with an expansion of endometrial T Regulatory cell and macrophage populations.

J Reprod Immunol 2018 Sep 4;129:36-39. Epub 2018 Aug 4.

Repromed, 180 Fullarton Road, Dulwich, South Australia 5065, Australia; Department of Obstetrics, Gynaecology and Reproductive Medicine, Flinders University, Bedford Park, South Australia 5042, Australia. Electronic address:

Obesity is associated with implantation failure, miscarriage, low-grade inflammation and a reduction in peripheral immune-suppressive T regulatory (Treg) cells. Therefore, we postulated that this reduction may also extend to the endometrium and cause embryonic loss. In a cohort of 40 infertile women, without implantation failure or recurrent miscarriage, we examined the density of Treg cells, macrophages and natural killer (NK) cells in mid-luteal endometrial biopsies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650378183008
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http://dx.doi.org/10.1016/j.jri.2018.08.004DOI Listing
September 2018
4 Reads

Annexin A1, FPR2/ALX, and inflammatory cytokine expression in peritoneal endometriosis.

J Reprod Immunol 2018 Sep 3;129:30-35. Epub 2018 Aug 3.

Postgraduate Program in Health Sciences, University of Southern Santa Catarina (UNISUL), Campus Grande Florianópolis, Avenida Pedra Branca, 25, Palhoça, SC, CEP 88137-270 Brazil. Electronic address:

To characterize Annexin A1 (ANXA1), FPR2/ALX and cytokines expression in peritoneal endometriosis and to clarify their role in its etiology, a cross-sectional study was performed with forty women in reproductive age (22 patients with endometriosis and 18 control women) that had undergone laparoscopic surgery. Peritoneal biopsy and fluid aspirations from endometriosis and control samples were analyzed for the expression of ANXA1, FPR2/ALX and cytokines. ANXA1 and FPR2 / ALX levels were measured by Western blotting and interleukin 1ß (IL-1β), interleukin 4 (IL-4), interleukin 6 (IL-6), and interleukin 10 (IL-10) levels were quantified by enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.1016/j.jri.2018.08.002DOI Listing
September 2018

The combination of maternal KIR-B and fetal HLA-C2 is associated with decidua basalis acute atherosis in pregnancies with preeclampsia.

J Reprod Immunol 2018 Sep 25;129:23-29. Epub 2018 Jul 25.

Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Division of Obstetrics and Gyneacology, Oslo University Hospital, Norway.

Acute atherosis is an arterial lesion most often occurring in pregnancies complicated by preeclampsia, a hypertensive pregnancy disorder. Acute atherosis predominates in the maternal spiral arteries in the decidua basalis layer of the pregnant uterus. This layer forms the fetal-maternal immunological interface, where fetal extravillous trophoblasts interact with maternal immune cells to promote decidual spiral artery remodeling and maternal immune tolerance towards the fetus. Read More

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http://dx.doi.org/10.1016/j.jri.2018.07.005DOI Listing
September 2018

Significant correlation between regulatory T cells and vitamin D status in term and preterm labor.

J Reprod Immunol 2018 Sep 18;129:15-22. Epub 2018 Jul 18.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt. Electronic address:

Background And Aim: Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Also, vitamin D is known to play a role in promoting the function of regulatory T-cells (Tregs). Tregs play an important role in suppressing the immune response during pregnancy. Read More

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http://dx.doi.org/10.1016/j.jri.2018.07.004DOI Listing
September 2018
14 Reads

Inflammation induced preterm labor and birth.

J Reprod Immunol 2018 Sep 30;129:53-58. Epub 2018 Jun 30.

Clinical Immunology Laboratory, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, United States.

Preterm birth which occurs before 37 weeks gestation is one of the most common obstetrical complication in humans. After many studies, it appears that "not one answer fits all" regarding the risk factors, causes and the treatments for this syndrome. However, it is becoming more evident that one of the major risk factors is inflammation and/or infection in the fetoplacental unit. Read More

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http://dx.doi.org/10.1016/j.jri.2018.06.029DOI Listing
September 2018
2 Reads

MICA-129 A/G dimorphism, its relation to soluble mica plasma level and spontaneous preterm birth: A case-control study.

J Reprod Immunol 2018 Sep 10;129:9-14. Epub 2018 Jul 10.

Department of Gynecology and Obstetrics, Infectious diseases in Gynecology and Obstetrics Sector, Clinics Hospital of University of Paraná (UFPR), Post Graduate Program of Gynecology and Obstetrics, Rua General Carneiro, 181, Alto da Glória, CEP80060-900 Curitiba, Paraná, Brazil. Electronic address:

The aim of this case- control study was to investigate the association between preterm birth (PTB), MICA-129 A/G dimorphism and sMICA levels. Fifty pregnant women with singleton pregnancy and previous PTB, or clinic diagnostic of threatened preterm labor in the actual pregnancy, or cervical length less than 25 mm and 50 healthy pregnant women were enrolled. DNA was extracted for genotyping for MICA-129 A/G by real-time PCR and sMICA plasma level was quantified by sandwich ELISA assay. Read More

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http://dx.doi.org/10.1016/j.jri.2018.07.002DOI Listing
September 2018
1 Read

Preeclampsia serum induces human glomerular vascular endothelial cell hyperpermeability via the HMGB1-Caveolin-1 pathway.

J Reprod Immunol 2018 Sep 6;129:1-8. Epub 2018 Jul 6.

Obstetric Intensive Care Center, The Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

To explore new ideas about the pathogeny of preeclampsia (PE) proteinuria, this study focused on whether severe PE serum (PES) could induce high-molecular-weight protein (HMWP) hyperpermeability in glomerular endothelial cells (GEC) via the HMGB1-Caveolin-1 (CAV-1) pathway. Normal pregnancy serum (NPS) and severe PES were used to treat primary human GEC monolayer for 24 h. The CAV-1 inhibitor methyl-beta-cyclodextrin (MBCD), the HMGB1 inhibitor glycyrrhizicacid (GA), recombinant HMGB1 (rHMGB1) were also used to treat GEC monolayer that were stimulated by NPS or severe PES. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650378183000
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http://dx.doi.org/10.1016/j.jri.2018.07.001DOI Listing
September 2018
10 Reads

HLA-DR is aberrantly expressed at feto-maternal interface in pre-eclampsia.

J Reprod Immunol 2018 Sep 19;129:48-52. Epub 2018 Jun 19.

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, OX3 9DU, UK.

In normal pregnancy, villous cytotrophoblast and syncytiotrophoblast do not express HLA Class I and Class II molecules, while invasive extravillous trophoblast only express class I HLA-C and the atypical class Ib antigens, HLA-G, -E and -F. Inadequate maternal tolerance of invasive trophoblast has been proposed as a possible immunologic trigger of poor trophoblast invasion and subsequent occurrence of pre-eclampsia. This study aimed to investigate possible aberrant expression of class II HLA-DR on placentae and syncytiotrophoblast-derived extracellular vesicles (STEVs), obtained by dual placental perfusion, from pre-eclampsia (n = 23) and normal pregnant (n = 14) women. Read More

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http://dx.doi.org/10.1016/j.jri.2018.06.024DOI Listing
September 2018

Soluble CD200 in secretory phase endometriosis endometrial venules may explain endometriosis pathophysiology and provide a novel treatment target.

J Reprod Immunol 2018 Sep 21;129:59-67. Epub 2018 May 21.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Retrograde menstruation is common and in about 10% of women, endometrial tissues implant at ectopic sites and grow as endometriosis (EM) deposits. To date, there has been no marker to identify which patients have an endometrium that will generate deposits. Both endometrial regulatory T cells (Tregs) and increased stromal cell indoleamine 2,3-dioxygenase (IDO) have been implicated, and may suppress rejection by peritoneal NK cells, neutrophils, and cytotoxic macrophages. Read More

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http://dx.doi.org/10.1016/j.jri.2018.05.006DOI Listing
September 2018
2 Reads

Innate immune responses to toll-like receptor stimulation are altered during the course of pregnancy.

J Reprod Immunol 2018 Aug 24;128:30-37. Epub 2018 May 24.

Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistrasse 52, Hamburg, 20251, Germany. Electronic address:

During pregnancy the maternal immune system has to develop tolerance towards the developing fetus. These changes in maternal immunity can result in increased severity of certain infections, but also in amelioration of autoimmune diseases. Pregnancy-related hormones have been suggested to play a central role in the adaptation of the maternal immune system, but their specific effects on innate immune function is not well understood. Read More

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http://dx.doi.org/10.1016/j.jri.2018.05.009DOI Listing
August 2018
5 Reads

Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum.

J Reprod Immunol 2018 Aug 22;128:23-29. Epub 2018 May 22.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Gynaecology and Obstetrics, Oslo University Hospital, Oslo, Norway.

Background: Uteroplacental acute atherosis is a pregnancy-specific lesion resembling early stages of atherosclerosis found frequently in preeclampsia. Preeclampsia is associated with an increased risk for future maternal atherosclerotic cardiovascular disease. The renin-angiotensin-system plays a role both in atherosclerosis and in preeclampsia. Read More

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http://dx.doi.org/10.1016/j.jri.2018.05.008DOI Listing

Sleep duration and C-reactive protein: Associations among pregnant and non-pregnant women.

J Reprod Immunol 2018 Aug 24;128:9-15. Epub 2018 May 24.

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States; Center on Aging and Health, Johns Hopkins University, Baltimore, MD, United States. Electronic address:

Pregnant women experience more sleep disturbances and greater systemic inflammation than non-pregnant women. However, the few studies that have examined the links between sleep and inflammation in pregnant women have been in clinical samples. We examined whether sleep duration is associated with C-reactive protein (CRP) levels, a marker of inflammation, in pregnant and non-pregnant women in a population-based sample of US women. Read More

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http://dx.doi.org/10.1016/j.jri.2018.05.003DOI Listing
August 2018
2 Reads

The duration of sexual relationship and its effects on adverse pregnancy outcomes.

J Reprod Immunol 2018 Aug 18;128:16-22. Epub 2018 May 18.

Adelaide Medical School, University of Adelaide, South Australia, Australia; Robinson Research Institute, University of Adelaide, Australia; Division of Women's Health, Lyell McEwin Hospital, Elizabeth Vale, South Australia, Australia. Electronic address:

This study aims to determine if a short duration of sexual relationship is more common among women who experience adverse pregnancy outcomes including gestational hypertension (GHT), preeclampsia, small for gestational age (SGA) pregnancies and spontaneous preterm birth (sPTB) with or without abnormal uterine artery Doppler compared to women who have uncomplicated pregnancies. 5591 nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study were included. The risk for pregnancy complications for women who had a duration of sexual relationship of ≤3 months, 4-6 months, 7-9 months, 10-12 months was compared with women who had a duration of sexual relationship of >12 months. Read More

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http://dx.doi.org/10.1016/j.jri.2018.05.007DOI Listing
August 2018
1 Read

Soluble inflammatory mediators induce transcriptional re-organization that is independent of dna methylation changes in cultured human chorionic villous trophoblasts.

J Reprod Immunol 2018 Aug 23;128:2-8. Epub 2018 May 23.

Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA; Genetics, Genomics, & Bioinformatics Program, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA. Electronic address:

The studies proposed here were undertaken to test the hypothesis that, under specific circumstances (e.g., a strong enough inflammatory stimulus), genes that are repressed at the maternal-fetal interface via DNA methylation might be de-methylated, allowing either a maternal immune response to the semi-allogenic fetus or the onset of early labor. Read More

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http://dx.doi.org/10.1016/j.jri.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086739PMC
August 2018
3 Reads

Editorial of the themed issue on 10th workshop on immunology of preeclampsia.

J Reprod Immunol 2018 Aug 17;128. Epub 2018 May 17.

INSERM, Paris, France.

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http://dx.doi.org/10.1016/j.jri.2018.05.004DOI Listing

Inhibition of pregnancy-associated granulocytic myeloid-derived suppressor cell expansion and arginase-1 production in preeclampsia.

J Reprod Immunol 2018 Jun 9;127:48-54. Epub 2018 May 9.

The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address:

Myeloid-derived suppressor cells (MDSCs) expand in maternal peripheral blood and cord blood during normal pregnancy to maintain maternal-fetal tolerance. Here we investigated the expansion and function of MDSCs in preeclampsia (PE) patients. Maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs) were sampled from healthy pregnant women and PE patients, and analyzed for the frequencies and phenotypes of MDSCs and T cells. Read More

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http://dx.doi.org/10.1016/j.jri.2018.05.002DOI Listing
June 2018
2 Reads
2.820 Impact Factor

Maternal allergy as an isolated risk factor for early-onset preeclampsia: An epidemiological study.

J Reprod Immunol 2018 Jun 20;127:43-47. Epub 2018 Apr 20.

Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

Immunological mechanisms underlying the development of preeclampsia are well known, but no association to allergy has yet been demonstrated. The aim of this study was to assess the correlation between maternal pre-gestational allergy, and early-onset and late-onset preeclampsia, respectively. It was a retrospective cohort study including all women giving birth in the Norwegian cities of Stavanger (1996-2014) and Bergen (2009-2014). Read More

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http://dx.doi.org/10.1016/j.jri.2018.04.004DOI Listing
June 2018
4 Reads

Poly (I:C) and LPS induce distinct immune responses by ovarian stromal fibroblasts.

J Reprod Immunol 2018 Jun 9;127:36-42. Epub 2018 May 9.

Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, USA.

Despite its anatomical location, the ovary is a site of pathogen exposure in the human female reproductive tract (FRT). However, the role of ovarian stromal fibroblasts in immune protection is unclear. We generated a population of ovarian stromal fibroblasts derived from normal human ovaries that expressed the pattern recognition receptors TLR3, TLR4, RIG-I, & MDA5. Read More

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http://dx.doi.org/10.1016/j.jri.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991091PMC
June 2018
4 Reads

Pellino 1 is a novel regulator of TNF and TLR signalling in human myometrial and amnion cells.

J Reprod Immunol 2018 Jun 14;127:24-35. Epub 2018 Apr 14.

Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia; Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia. Electronic address:

Preterm birth is the primary cause of neonatal deaths and morbidities. Pathological processes causally linked to preterm birth are inflammation and infection. Pellino-1 (Peli1) has previously been found to regulate the inflammatory response in non-gestational tissues in response to toll-like receptor (TLR) ligands and pro-inflammatory cytokines. Read More

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http://dx.doi.org/10.1016/j.jri.2018.04.003DOI Listing
June 2018
14 Reads

Angiogenic factors in pregnancies of women with antiphospholipid syndrome and systemic lupus erythematosus.

J Reprod Immunol 2018 Jun 18;127:19-23. Epub 2018 Apr 18.

Department of Obstetrics, Department of Internal Medicine and Endocrinology Lab Platform, Medical University Graz, Graz, Austria.

Objectives: An imbalance of angiogenic placental factors such as endoglin, soluble fms-like tyrosine kinase 1(sFlt-1) and placental growth factor (PlGF) has been implicated in the pathophysiology of preeclampsia. This study aimed to evaluate serum levels of sFlt-1, PlGF and endoglin in women with primary and secondary antiphospholipid Syndrome (APS) and systemic lupus erythematosus (SLE) longitudinally through pregnancy.

Material And Methods: Serum levels of sFlt-1, PlGF and endoglin were measured prospectively at 4-week intervals (from gestational weeks 12-36) in 17 women with primary APS (PAPS), 18 women with secondary APS (SAPS), and 23 women with SLE. Read More

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http://dx.doi.org/10.1016/j.jri.2018.04.002DOI Listing
June 2018
6 Reads

Elevated systemic microbial translocation in pregnant HIV-infected women compared to HIV-uninfected women, and its inverse correlations with plasma progesterone levels.

J Reprod Immunol 2018 Jun 10;127:16-18. Epub 2018 Apr 10.

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA; Divison of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:

In HIV infection, increased adverse perinatal outcomes reported among HIV-associated pregnancies are not fully understood. Currently, microbial product translocation (MT) from a permeable mucosa is demonstrated as a driver of inflammation, and may contribute to preterm delivery in HIV. Here, our results showed that plasma LPS levels (a representative marker of MT) were increased in HIV-infected women in the first and second trimester. Read More

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http://dx.doi.org/10.1016/j.jri.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964028PMC
June 2018
2 Reads

Impact of prednisone in patients with repeated embryo implantation failures: Beneficial or deleterious?

J Reprod Immunol 2018 Jun 26;127:11-15. Epub 2018 Mar 26.

Institut National de Santé et de Recherche Médicale, INSERM UMR-976, Saint-Louis Hospital, Research Center, 1 Avenue Claude Vellefaux, 75010, Paris, France.

Introduction: Corticotherapy is the leading medication worldwide for patients with history of repeated implantation failures (RIF) after IVF/ICSI. Nevertheless, we still do not know its local mechanism of action, hence its precise indication. Our objective is to document the impact of prednisone on the endometrial expression of immune biomarkers (CD56 cells count, IL-18/TWEAK, IL-15/Fn-14 mRNA ratio) at the time of uterine receptivity in a RIF population. Read More

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http://dx.doi.org/10.1016/j.jri.2018.03.003DOI Listing
June 2018
7 Reads
2.820 Impact Factor

High serum IGF-1 levels are associated with pregnancy loss following frozen-thawed euploid embryo transfer cycles.

J Reprod Immunol 2018 Jun 16;127:7-10. Epub 2018 Mar 16.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10021, United States. Electronic address:

An elevated level of insulin growth factor (IGF-1) in rat uterine fluid has been shown to exert detrimental effects of embryo development possibly leading to an increase in pregnancy loss. Interestingly, the administration of somatostatin to rats undergoing superovulation reduced IGF-1 levels in uterine luminal fluid and thus reversed its deleterious effects on embryo development and increased the number of normal embryos. Therefore, we investigated whether serum levels of IGF-1 correlate with the incidence of pregnancy loss following IVF. Read More

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http://dx.doi.org/10.1016/j.jri.2018.03.002DOI Listing
June 2018
2 Reads

Trophoblast CD200 expression in successful human pregancies and missed abortions.

J Reprod Immunol 2018 Jun 16;127:55-57. Epub 2018 Mar 16.

Department of Pathology and Molecular Medicine, McMaster University, Canada.

Presence of the CD200 immune check-point inhibitor at the feto-maternal interface is linked to prevention of spontaneous abortion in mice and humans. In human missed abortions (MA), absence of Th17-driven inflammation has been attributed to expression of villus trophoblast CD200 quantified using immunohistochemistry. While rapid aneuploidy (QF-PCR) testing linked low CD200 to pregnancy failure, data showing normal VT CD200 in first trimester normal pregnancy and in abortion of chromosomally abnormal embryos has not been demonstrated. Read More

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http://dx.doi.org/10.1016/j.jri.2018.03.001DOI Listing
June 2018
4 Reads

First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age.

J Reprod Immunol 2018 Jun 2;127:1-6. Epub 2018 Mar 2.

Department of Clinical Sciences, Lund University Clinical Research Center, Skåne University Hospital, 205 02 Malmö, Sweden. Electronic address:

Background: Autoimmune (type 1) diabetes (T1D) is a frequent chronic disease in children and adolescents globally. Gestational enterovirus (EV) infections have been associated with an increased risk for T1D in the offspring. We test the hypothesis that EV infections during the first trimester were associated with beta cell autoantibodies in mothers of children who developed islet autoantibodies before 7 years of age. Read More

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http://dx.doi.org/10.1016/j.jri.2018.02.004DOI Listing
June 2018
3 Reads

Circulating pathogen-specific plasmablasts in female patients with upper genital tract infection.

J Reprod Immunol 2018 Apr 2;126:69-75. Epub 2018 Mar 2.

Inflammation Center, Clinic of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Unit of Infectious Diseases, Department of Medicine/Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Mucosal antibodies constitute the first line of adaptive immune defence against invaders in the female genital tract (FGT), yet the sequence of events leading to their production is surprisingly poorly characterized. We explored the induction of pathogen-specific antibody-secreting cells (ASC) as a response to an acute infection in the upper FGT. We recruited 12 patients undergoing surgery due to an upper FGT infection (7/12 blood culture positive, 5/12 negative) and six healthy controls. Read More

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http://dx.doi.org/10.1016/j.jri.2018.02.005DOI Listing
April 2018
2 Reads

Polybacterial stimulation suggests discrete IL-6/IL-6R signaling in human fetal membranes: Potential implications on IL-6 bioactivity.

J Reprod Immunol 2018 Apr 2;126:60-68. Epub 2018 Mar 2.

Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, United States. Electronic address:

The polybacterial invasion of the amniotic cavity and risk of preterm birth is often due to cervicovaginal bacteria such as genital mycoplasmas (Mycoplasma hominis and Ureaplasma urealyticum) and Gardnerella vaginalis. The most studied biomarker associated with preterm birth is interleukin-6 (IL-6), a pleiotropic cytokine that performs different functions based on classical or trans-signaling mechanisms. This study evaluated the changes in IL-6 and IL-6 function associated accessory molecules by human fetal membranes to determine the functional availability of IL-6 assessment in an in vitro model of polybacterial infection. Read More

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http://dx.doi.org/10.1016/j.jri.2018.02.007DOI Listing
April 2018
4 Reads

Immune profile in relation to sex steroid cyclicity in healthy women and women with multiple sclerosis.

J Reprod Immunol 2018 Apr 2;126:53-59. Epub 2018 Mar 2.

Clinical Immunology and Transfusion Medicine, Department of Clinical and Experimental Medicine, Linköping University, SE-58185, Linköping, Sweden.

To prospectively study systemic in vivo immunological effects of sex hormones, using different phases of oral combined hormonal contraceptives (CHC), and the natural menstrual cycles in both healthy women and in women with multiple sclerosis (MS), blood samples from sixty female MS patients and healthy controls with and without CHC were drawn in high and low estrogenic/progestogenic phases. Expression of Th-associated genes in blood cells was determined by qPCR and a panel of cytokines and chemokines was measured in plasma. High hormone level phases were associated with increases in Th1 (TBX21) and Th2 (GATA3) associated markers, as well as the B cell-associated chemokine CXCL13, while the inhibitory regulator CTLA-4 was decreased. Read More

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http://dx.doi.org/10.1016/j.jri.2018.02.006DOI Listing
April 2018
4 Reads

Lower frequency of the HLA-G UTR-4 haplotype in women with unexplained recurrent miscarriage.

J Reprod Immunol 2018 Apr 7;126:46-52. Epub 2018 Feb 7.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, 2300RC, The Netherlands.

HLA-G expressed by trophoblasts at the fetal-maternal interface and its soluble form have immunomodulatory effects. HLA-G expression depends on the combination of DNA polymorphisms. We hypothesized that combinations of specific single nucleotide polymorphisms (SNPs) in the 3'untranslated region (3'UTR) of HLA-G play a role in unexplained recurrent miscarriage. Read More

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http://dx.doi.org/10.1016/j.jri.2018.02.002DOI Listing
April 2018
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Maternal and child human leukocyte antigens in congenital cytomegalovirus infection.

J Reprod Immunol 2018 Apr 31;126:39-45. Epub 2018 Jan 31.

Department of Medical Microbiology, Leiden University Medical Center, Leiden (LUMC), The Netherlands. Electronic address:

Congenital Cytomegalovirus infection (cCMV) is the most common cause of congenital infections worldwide causing permanent long-term impairment (LTI). cCMV immunopathogenesis remains largely unknown due to the complex interplay between viral, maternal, placental and child factors. The aim of this study was to determine the possible role of particular HLA antigens, of the number of HLA mismatches (mm) and non-inherited maternal antigens (NIMAs) in a large retrospective nation-wide cohort of children with cCMV and their mothers. Read More

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http://dx.doi.org/10.1016/j.jri.2018.01.002DOI Listing
April 2018
2 Reads

Treg and NK cells related cytokines are associated with deep rectosigmoid endometriosis and clinical symptoms related to the disease.

J Reprod Immunol 2018 Apr 6;126:32-38. Epub 2018 Feb 6.

Hospital Israelita Albert Einstein - Avenida Albert Einstein, 627, Morumbi, CEP: 05652-900, Sao Paulo, Brazil; Department of Obstetrics and Gynecology, University of Sao Paulo Medical School - Av. Dr. Enéas de Carvalho Aguiar, 255, Cerqueira César, CEP: 05403-000, Sao Paulo, Brazil.

The aim of this study was to evaluate Treg and NK cells related cytokines in deep infiltrating endometriosis lesions and its relationship with clinical symptoms of the disease. mRNA expression of Transforming Growth Factor Beta (TGFB), Interleukin (IL)10, Interferon Gamma (IFNG), IL7, and IL15 was analyzed by Real-Time PCR in eutopic endometrium and rectosigmoid lesions from 11 women with deep infiltrating endometriosis and in eutopic endometrium from 11 healthy women. IL10, IFNG, and IL7 expression was significantly higher in endometriotic bowel lesions than in eutopic endometrium from women with endometriosis. Read More

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http://dx.doi.org/10.1016/j.jri.2018.02.003DOI Listing
April 2018
1 Read

Physiological low-dose oestrogen promotes the development of experimental autoimmune thyroiditis through the up-regulation of Th1/Th17 responses.

J Reprod Immunol 2018 Apr 7;126:23-31. Epub 2018 Feb 7.

Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital, China Medical University, Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, P. R. China. Electronic address:

Previous studies have reported a preponderance of autoimmune thyroiditis (AIT) in females, but the detailed mechanisms have not been elucidated. In this study, we explored the effects of oestrogen on experimental AIT (EAT) and its potential mechanisms in an ovariectomised mouse model through the supplementation of high (equivalent to the level during pregnancy) or low (equivalent to the level at the oestrus stage) doses of oestradiol (E2). We found that EAT incidence, the intrathyroidal inflammatory score, serum anti-thyroglobulin IgG2b levels, splenic mRNA expression of Th1- and Th17-specific transcription factors and typical cytokines and the proportion of IL-12-producing dendritic cells were significantly increased in EAT mice treated with low-dose E2 compared with those in the control group. Read More

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http://dx.doi.org/10.1016/j.jri.2018.02.001DOI Listing
April 2018
6 Reads