152,946 results match your criteria Journal of Prenatal & Perinatal Psychology & Health [Journal]


Vitamin B Status in Pregnant Adolescents and Their Infants.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

Vitamin B deficiency has been associated with increased risk of adverse pregnancy outcomes. Few prospective studies have investigated the burden or determinants of vitamin B deficiency early in life, particularly among pregnant adolescents and their children. The objectives of this study were to determine the prevalence of vitamin B deficiency and to examine associations between maternal and neonatal vitamin B status in a cohort study of healthy pregnant adolescents. Read More

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http://dx.doi.org/10.3390/nu11020397DOI Listing
February 2019

Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group.

Pathogens 2019 Feb 18;8(1). Epub 2019 Feb 18.

Assistance Publique-Hôpitaux de Marseille, Department of Neonatal Medicine; Hospital of the Conception, 13005 Marseille, France.

Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up and relapses lifelong. Despite the possible severity of outcome, congenital toxoplasmosis (CT) is a neglected disease. Read More

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http://dx.doi.org/10.3390/pathogens8010024DOI Listing
February 2019

A Silicon-based Coral-like Nanostructured Microfluidics to Isolate Rare Cells in Human Circulation: Validation by SK-BR-3 Cancer Cell Line and Its Utility in Circulating Fetal Nucleated Red Blood Cells.

Micromachines (Basel) 2019 Feb 17;10(2). Epub 2019 Feb 17.

Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital; and Department of Genomic Science and Technology, Changhua Christian Hospital Healthcare System, Changhua 50046, Taiwan.

Circulating fetal cells (CFCs) in maternal blood are rare but have a strong potential to be the target for noninvasive prenatal diagnosis (NIPD). "Cell Reveal system" is a silicon-based microfluidic platform capable to capture rare cell populations in human circulation. The platform is recently optimized to enhance the capture efficiency and system automation. Read More

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http://dx.doi.org/10.3390/mi10020132DOI Listing
February 2019

Perception of Environmental Risks and Behavioral Changes during Pregnancy: A Cross-Sectional Study of French Postpartum Women.

Int J Environ Res Public Health 2019 Feb 16;16(4). Epub 2019 Feb 16.

Environmental Health Platform Dedicated to Reproduction, ARTEMIS Center, 33076 Bordeaux, France.

Limiting exposure to environmental hazards during preconception and pregnancy is essential for preventing adverse pregnancy outcomes or developmental defects in offspring. However, the perception of environmental risk and the behavioral changes of women planning or having a pregnancy have rarely been investigated, except for a few risk factors. We thus performed a cross-sectional study of French postpartum women hospitalized in the Bordeaux University Hospital in 2017 by proposing a self-administrated survey. Read More

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http://dx.doi.org/10.3390/ijerph16040565DOI Listing
February 2019

Alcohol and Women: A Brief Overview.

Alcohol Clin Exp Res 2019 Feb 19. Epub 2019 Feb 19.

Dept of Psychiatry, Neuroscience and Child Study, Yale University School of Medicine, New Haven, CT, 06510.

This paper provides a brief overview of research on women and alcohol and introduces a virtual issue of Alcoholism: Clinical and Experimental Research devoted to this important subject. Women-focused topics include the epidemiology of alcohol use among women, health and behavioral consequences of drinking, prenatal alcohol use and interventions, and enhanced alcohol treatment services. The introduction and selected papers highlight: temporal trends that are narrowing the gender gap in alcohol use; mounting evidence of the more rapid progression and greater severity of harmful physiological and behavioral effects of alcohol in women; impact of targeted public health campaigns and public policies on prenatal drinking; and finally intervention strategies to improve detection and care of women who misuse alcohol. Read More

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http://dx.doi.org/10.1111/acer.13985DOI Listing
February 2019

Prenatal diagnosis of Fragile X syndrome: small meiotic recombination events at the FMR1 locus.

Prenat Diagn 2019 Feb 18. Epub 2019 Feb 18.

Service de Génétique, CHRU de Tours, UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Objective: Fragile X syndrome (FXS), the most common inherited cause of intellectual disability, is caused by an expansion over 200 CGG repeats (full mutation) in the FMR1 gene. Intergenerational instability of an expanded FMR1 allele is linked to the carrier's gender (female), the CGG repeat size and the number of AGG interspersions within the CGG repeat, making genetic counseling a complex task. The objective of our work was to emphasize the importance of combining haplotype analysis with FMR1 linked markers and CGG repeat sizing for prenatal diagnosis (PND) of FXS. Read More

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http://dx.doi.org/10.1002/pd.5439DOI Listing
February 2019

Women's experience with group prenatal care in a rural community in northern Nigeria.

Int J Gynaecol Obstet 2019 Feb 18. Epub 2019 Feb 18.

Department of Obstetrics and Gynaecology, Ahmadu Bello University, Zaria, Nigeria.

Objective: To assess women's experience of group prenatal care in a rural Nigerian community.

Methods: In an observational study, consenting pregnant women were enrolled in a group prenatal care program based on the CenteringPregnancy model from July 1, 2010, to June 30, 2011, in Tsibiri, Nigeria. Women were interviewed before joining the group and postnatally. Read More

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http://dx.doi.org/10.1002/ijgo.12788DOI Listing
February 2019

Maternal hypothyroidism and future pediatric neurological morbidity of the offspring.

Arch Gynecol Obstet 2019 Feb 18. Epub 2019 Feb 18.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, 151 Izak Rager Ave., 84101, Beer-Sheva, Israel.

Background: Maternal hypothyroidism in pregnancy has been associated with neurocognitive impairment in exposed children, ranging from psychomotor-developmental delay to lower IQ scores.

Objective: To investigate the long-term neurological morbidity of children to hypothyroid mothers during pregnancy.

Study Design: A population-based cohort study was performed including all deliveries occurring in a period of 20 years at a tertiary medical center. Read More

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http://dx.doi.org/10.1007/s00404-019-05092-1DOI Listing
February 2019

In prenatally diagnosed CPAM, does the affected lobe influence the timing of symptom onset?

Pediatr Surg Int 2019 Feb 16. Epub 2019 Feb 16.

Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan.

Purpose: We investigated the relationship between the affected lobe and symptom onset in prenatally diagnosed congenital pulmonary airway malformation (CPAM).

Methods: 53 CPAM patients diagnosed prenatally were reviewed retrospectively by creating 2 groups according to symptom onset. Group Sneo: (symptomatic during the neonatal period; n = 13) and group S > neo: (symptomatic after the neonatal period; n = 40) were compared for type of CPAM, affected lobes, types of symptoms/infections, treatment, duration of follow-up, and histopathology. Read More

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http://dx.doi.org/10.1007/s00383-019-04460-xDOI Listing
February 2019

Associations of prenatal exposure to polybrominated diphenyl ethers and polychlorinated biphenyls with long-term gut microbiome structure: a pilot study.

Environ Epidemiol 2019 Feb;3(1)

Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA.

Background: The gut microbiome is influenced by early-life exposures, but-despite potentially enormous implications for child health-is understudied in environmental epidemiology. This pilot study is one of the first to explore exposures and long-term gut microbiome profiles. We examined the association between exposure to polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) during pregnancy and the mid-childhood gut microbiome. Read More

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http://dx.doi.org/10.1097/EE9.0000000000000039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376400PMC
February 2019

Age-Characteristic Changes of Glucose Metabolism, Pancreatic Morphology and Function in Male Offspring Rats Induced by Prenatal Ethanol Exposure.

Front Endocrinol (Lausanne) 2019 4;10:34. Epub 2019 Feb 4.

Department of Pharmacology, School of Basic Medical Sciences of Wuhan University, Wuhan, China.

Intrauterine growth restricted offspring suffer from abnormal glucose homeostasis and β cell dysfunction. In this study, we observed the dynamic changes of glucose metabolic phenotype, pancreatic morphology, and insulin synthesis in prenatal ethanol exposure (PEE) male offspring rats, and to explore the potential intrauterine programming mechanism of the glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis. Ethanol (4 g/kg·d) was administered through oral gavage during gestational day (GD) 9-20. Read More

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http://dx.doi.org/10.3389/fendo.2019.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369175PMC
February 2019

Antenatal care utilisation among Syrian refugees in Tehran: A respondent driven sampling method.

Women Birth 2019 Feb 15. Epub 2019 Feb 15.

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Aim: To assess the antenatal care utilisation among Syrian refugees in Tehran.

Methods: This cross-sectional study was performed in 2016 in Tehran. As the refugees live in the city, we used Respondent Driven Sampling method for finding participants. Read More

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http://dx.doi.org/10.1016/j.wombi.2019.02.001DOI Listing
February 2019

The effect of prenatal smoke exposure on child neuropsychological function: a prospective mother-child cohort study.

J Reprod Infant Psychol 2019 Feb 19:1-13. Epub 2019 Feb 19.

a Centre de Recerca en Avaluació i Mesura de la Conducta (CRAMC) , Universitat Rovira i Virgili (URV) , Tarragona , Spain.

Objective: To study prospectively the effect of prenatal smoke exposure (PSE) on child neuropsychological function and intelligence quotient (IQ).

Background: PSE has been associated with adverse effects on child neurodevelopment. However, some studies reported that these associations disappear after adjustment for potential confounders. Read More

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http://dx.doi.org/10.1080/02646838.2019.1580350DOI Listing
February 2019

Differences in Prenatal Care by Presence and Type of Maternal Disability.

Am J Prev Med 2019 Mar;56(3):376-382

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon; National Institute of Public Health, Cuernavaca, Mexico.

Introduction: Prior studies have found that women with disabilities are less likely to receive adequate prenatal care than women without disabilities. However, little is known about differences in patterns of prenatal care by type of disability. Therefore, this study examined timing and frequency of prenatal care among women with physical, sensory, or intellectual/developmental disabilities compared with women without disabilities. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.021DOI Listing

Relation of prenatal low-level mercury exposure with early child neurobehavioral development and exploration of the effects of sex and DHA on it.

Environ Int 2019 Feb 15;126:14-23. Epub 2019 Feb 15.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background: The extent to which low-level, in utero mercury exposure affects child neurobehavioral development during early childhood has been inconclusive. In addition, the effects of sex and docosahexaenoic acid (DHA) on these relationships remain unclear and controversial.

Objectives: This study aimed to explore the associations between prenatal low-level mercury exposure and child neurobehavioral development during the neonatal and toddler periods and to examine the potential confounding or interactive effects of sex and DHA status on these relationships. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183194
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http://dx.doi.org/10.1016/j.envint.2019.02.012DOI Listing
February 2019
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Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway.

Toxicology 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic address:

This study aimed to evaluate female adult offspring induced by prenatal caffeine exposure (PCE) are susceptible to non-alcoholic fatty liver disease (NAFLD) and to explore the underlying programming mechanisms. Pregnant rats were intragastrically administered caffeine (30, 60, and 120 mg/kg.d) on gestational day (GD) 9-20. Read More

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http://dx.doi.org/10.1016/j.tox.2019.02.008DOI Listing
February 2019

[Fetal alcohol spectrum disorder. An underdiagnosed neuro-development disorder of uncertain prognosis].

Medicina (B Aires) 2019 ;79 Suppl 1:62-67

Departament de Psicologia i Psicobiologia Clínica, Universitat de Barcelona, Barcelona, España.

Prenatal exposure to alcohol is the cause of cognitive and behavioural disorders grouped under the term fetal alcohol spectrum disorders (FASD). The long-term evolution of subjects with FASD is often unfavourable, especially in social and academic fields. Executive dysfunction is a hallmark deficit for children with FASD with increased rates of externalizing behaviours, such as aggressiveness and frequently delinquency in adolescence and adulthood. Read More

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January 2019

Prenatal imaging of genital defects: clinical spectrum and predictive factors for severe forms.

BJU Int 2019 Feb 18. Epub 2019 Feb 18.

Unité de Chirurgie Viscérale et Urologique Pédiatrique, Hôpital Lapeyronie - CHU Montpellier, France, et Université de Montpellier, France.

Objectives: 1-To report the clinical spectrum of genital defects diagnosed before birth, 2- to identify predictive factors for severe phenotypes at birth 3- to determine the rate of associated malformations.

Methods: A retrospective study (2008-2017) of 4580 fetuses identified prenatally with abnormalities evaluated by our Reference Center for Fetal Medicine included cases with fetal sonographic finding of abnormal genitalia or uncertainty of fetal sex determination. Familial, prenatal and postnatal data were collected through a standardized questionnaire. Read More

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http://dx.doi.org/10.1111/bju.14714DOI Listing
February 2019

Context for implementing a gestational weight gain program nationally.

Health Behav Policy Rev 2018 Sep;5(5):77-89

The Brown School and The School of Medicine, Washington University in St. Louis, 1 Brookings Dr, St. Louis, MO, 63130, USA, phone: 314-935-3963, ,

Objectives: Use the Consolidated Framework for Implementation Research to describe the context in which a gestational weight gain (GWG) intervention, embedded within Parents as Teachers (PAT), will be implemented at PAT sites nationwide.

Methods: Ten site leaders and six parent educators from ten PAT sites in eight states participated in semi-structured interviews and a survey. Audio-recordings and systematic notes were used in a deductive analysis. Read More

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http://dx.doi.org/10.14485/HBPR.5.5.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374035PMC
September 2018

Systems Biology Approaches Toward Understanding Primary Mitochondrial Diseases.

Front Genet 2019 1;10:19. Epub 2019 Feb 1.

Mitochondrial Research Group, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Primary mitochondrial diseases form one of the most common and severe groups of genetic disease, with a birth prevalence of at least 1 in 5000. These disorders are multi-genic and multi-phenotypic (even within the same gene defect) and span the entire age range from prenatal to late adult onset. Mitochondrial disease typically affects one or multiple high-energy demanding organs, and is frequently fatal in early life. Read More

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http://dx.doi.org/10.3389/fgene.2019.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367241PMC
February 2019

Qualitative assessment of knowledge transfer regarding preterm birth in Malawi following the implementation of targeted health messages over 3 years.

Int J Womens Health 2019 30;11:75-95. Epub 2019 Jan 30.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA,

Background: In 2012, we performed a needs assessment and gap analysis to qualitatively assess providers' and patients' knowledge and perceptions regarding preterm birth (PTB). During the study, we identified knowledge gaps surrounding methods to reduce the risk of occurrence of PTB and management options if preterm labor/birth occur. We targeted health messages toward these gaps. Read More

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http://dx.doi.org/10.2147/IJWH.S185199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361229PMC
January 2019

[France and Great-Britain at the age of genomic medicine: new ethical challenges in reproductive medicine].

Authors:
Ruth Horn

Med Sci (Paris) 2019 Feb 18;35(2):163-168. Epub 2019 Feb 18.

The Ethox Centre, Wellcome Centre for Ethics and Humanities, University of Oxford, Old Road Campus, Oxford, OX3 7LF, Royaume-Uni.

The announcement of the French Plan 'France Médecine Génomique 2015' demonstrates the will of the public authorities to make genomic medicine one of the flagships of public health and scientific research. It is against this backdrop that France announced its cooperation with Great Britain, one of the global leaders in genomics. The cooperation at an international level requires a common normative framework that addresses the new ethical challenges presented by genomic medicine. Read More

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http://dx.doi.org/10.1051/medsci/2019004DOI Listing
February 2019

The effect of maternal depression and anxiety on labour and the well-being of the newborn.

J Obstet Gynaecol 2019 Feb 16:1-6. Epub 2019 Feb 16.

b Department of Health Sciences , University of Florence , Florence , Italy.

Maternal symptomatology during pregnancy represents a significant risk factor for women and children. The main focus of this paper is to jointly investigate the role of maternal depression and anxiety during pregnancy on the well-being of the newborn, through their influences on the clinical aspects of labour. A longitudinal study was conducted on 167 pregnant women (M=32. Read More

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http://dx.doi.org/10.1080/01443615.2018.1536697DOI Listing
February 2019

Pregnancy-specific coping and changes in emotional distress from mid- to late pregnancy.

J Reprod Infant Psychol 2019 Feb 17:1-16. Epub 2019 Feb 17.

a Department of Psychology , Stony Brook University , Stony Brook , NY , USA.

Objective: To examine whether pregnancy-specific coping predicts changes in emotional distress from mid- to late pregnancy.

Background: There is a need to identify ways of coping that reduce or elevate emotional distress in pregnant women as such distress increases the risk of adverse birth outcomes.

Methods: 132 women receiving prenatal care from a university hospital midwifery practice were recruited prior to 25 weeks gestation (M = 19. Read More

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http://dx.doi.org/10.1080/02646838.2019.1578871DOI Listing
February 2019

Mendelian Randomization and the Environmental Epigenetics of Health: a Systematic Review.

Curr Environ Health Rep 2019 Feb 18. Epub 2019 Feb 18.

Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Av. Menendez Pelayo 4 accesorio, 46010, Valencia, Spain.

Purpose Of Review: Epigenetic modifications are environmentally responsive and may play a mechanistic role in the development of disease. Mendelian randomization uses genetic variation to assess the causal effect of modifiable exposures on health outcomes. We conducted a systematic review of Mendelian randomization studies evaluating the causal role of DNA methylation (DNAm) changes on the development of health states, emphasizing on studies that formally evaluate exposure-DNAm, in addition to DNAm-outcome, causal associations. Read More

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http://dx.doi.org/10.1007/s40572-019-0226-3DOI Listing
February 2019

Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation.

J Vet Med Sci 2019 Feb 15. Epub 2019 Feb 15.

The Institute of Environmental Toxicology.

The aim of this study is to identify the combined effect of multiple chemicals to the development of allergy. In this study, the effect of prenatal exposure to an organochlorine agent methoxychlor (MXC) and/or an organophosphate agent parathion (PARA) on trimellitic anhydride-induced allergic airway inflammation was examined in mice. Eosinophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly enhanced by MXC+PARA exposure compared to that of the control, MXC, and PARA groups. Read More

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http://dx.doi.org/10.1292/jvms.18-0641DOI Listing
February 2019

Atypical Segmental Spinal Dysgenesis: Prenatal Diagnosis With Postpartum Short-Term Follow-Up.

J Obstet Gynaecol Can 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

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http://dx.doi.org/10.1016/j.jogc.2018.07.012DOI Listing
February 2019

Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.

Am J Hum Genet 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

SPONASTRIME dysplasia is an autosomal-recessive spondyloepimetaphyseal dysplasia characterized by spine (spondylar) abnormalities, midface hypoplasia with a depressed nasal bridge, metaphyseal striations, and disproportionate short stature. Scoliosis, coxa vara, childhood cataracts, short dental roots, and hypogammaglobulinemia have also been reported in this disorder. Although an autosomal-recessive inheritance pattern has been hypothesized, pathogenic variants in a specific gene have not been discovered in individuals with SPONASTRIME dysplasia. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.01.007DOI Listing
February 2019

Critical Growth Processes for the Midfacial Morphogenesis in the Early Prenatal Period.

Cleft Palate Craniofac J 2019 Feb 17:1055665619827189. Epub 2019 Feb 17.

1 Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background:: Congenital midfacial hypoplasia often requires intensive treatments and is a typical condition for the Binder phenotype and syndromic craniosynostosis. The growth trait of the midfacial skeleton during the early fetal period has been assumed to be critical for such an anomaly. However, previous embryological studies using 2-dimensional analyses and specimens during the late fetal period have not been sufficient to reveal it. Read More

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http://dx.doi.org/10.1177/1055665619827189DOI Listing
February 2019

Unilateral Renal Agenesis Diagnosed on Early Prenatal Trans-Vaginal Scans.

Isr Med Assoc J 2019 Feb;21(2):85-87

Department of Obstetrics and Gynecology, Rambam Medical Center, affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Unilateral renal agenesis is a rare finding. There are no large-scale studies reporting this finding in early pregnancy.

Objectives: To evaluate the incidence of unilateral renal agenesis (URA) and of associated anomalies diagnosed by early prenatal trans-vaginal sonography. Read More

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February 2019
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Trends in resource use and effectiveness of ultrasound detection of fetal structural anomalies in France: a multiple registry-based study.

BMJ Open 2019 Feb 15;9(2):e025482. Epub 2019 Feb 15.

Fetal Medicine Department, Sorbonne University, AP-HP, Armand Trousseau Hospital, Paris, France.

Objective: To analyse trends in the number of ultrasound examinations in relation to the effectiveness of prenatal detection of birth defects using population-based data in France.

Design: A multiple registry-based study of time trends in resource use (number of ultrasounds) and effectiveness (proportion of cases prenatally diagnosed).

Setting: Three registries of congenital anomalies and claims data on ultrasounds for all pregnant women in France. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025482DOI Listing
February 2019

Breastfeeding and behavioural problems: Propensity score matching with a national cohort of infants in Chile.

BMJ Open 2019 Feb 15;9(2):e025058. Epub 2019 Feb 15.

Psychology School, Pontificia Universidad Católica de Chile, Santiago, Chile.

Importance: Potential effects of breast feeding on children's behaviour remains an elusive debate given inherent methodological challenges. Propensity score matching affords benefits by ensuring greater equivalence on observable social and health determinants, helping to reduce bias between groups.

Objectives: We examined whether the duration of breast feeding had an impact on children's externalising and internalising behaviours. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025058DOI Listing
February 2019

Prenatal alcohol exposure and facial morphology in a UK cohort.

Drug Alcohol Depend 2019 Feb 5;197:42-47. Epub 2019 Feb 5.

MRC Integrative Epidemiology Unit, Population Health Sciences, Oakfield House, Oakfield Grove, University of Bristol, BS8 2BN, UK; Bristol Dental School, University of Bristol, UK. Electronic address:

Background: High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.

Methods: In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.11.031DOI Listing
February 2019

Dysgénésie spinale segmentaire atypique : diagnostic prénatal et suivi postpartum à court terme.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

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http://dx.doi.org/10.1016/j.jogc.2018.10.029DOI Listing
February 2019

Prenatal Diagnosis of Jejunal Atresia by 3-D Ultrasonography and MRI.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil; Medicine Course, Municipal University of São Caetano do Sul (USCS), São Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jogc.2018.06.022DOI Listing
February 2019

Diagnostic prénatal de l'atrésie jéjunale par échographie 3D et IRM.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil; Medicine Course, Municipal University of São Caetano do Sul (USCS), São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.jogc.2018.12.008DOI Listing
February 2019

Prenatal diagnosis and management of congenital diaphragmatic hernia.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 5. Epub 2019 Jan 5.

Academic Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Belgium; Clinical Department of Obstetrics & Gynaecology, KU Leuven, Leuven, Belgium; Institute for Women's Health, University College London, London, UK; European Reference Network on Rare and Inherited Congenital Anomalies "ERNICA". Electronic address:

Congenital diaphragmatic hernia is characterized by failed closure of the diaphragm, thereby allowing abdominal viscera to herniate into the thoracic cavity and subsequently interfering with normal lung development. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension (PHT), that is lethal in up to 32% of patients. In isolated cases, the outcome may be predicted prenatally by medical imaging and advanced genetic testing. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.010DOI Listing
January 2019
1 Read

Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan.

Int J Drug Policy 2019 Feb 13;67:1-8. Epub 2019 Feb 13.

Children and Family Research Center, National Taiwan University, Taipei, Taiwan.

Aims: The present study aims to investigate the utilization pattern of prenatal care and correlates for women with opioid use disorders (OUD) in Taiwan.

Method: Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013. The generalized linear mixed models with negative binomial and logit distributions were performed to evaluate the relationship between individual sociodemographic, health, and addiction treatment characteristics with the number of prenatal visits and receiving prenatal care in the first trimester (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09553959193003
Publisher Site
http://dx.doi.org/10.1016/j.drugpo.2019.01.024DOI Listing
February 2019
4 Reads

Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Maternal Fetal Medicine Unit. Department of Obstetrics. Hospital Universitari Vall d'Hebron. Ps. Vall d'Hebron 119-129, 08035 Barcelona. Universitat Autònoma de Barcelona.

Objectives: to describe pregnancy outcomes after Zika virus (ZIKV) infection in a non-endemic region.

Methods: according to the Spanish protocol issued after the ZIKV outbreak in Brazil in 2015, all pregnant women who had travelled to high-burden countries were screened for ZIKV. Serological and molecular tests were used to identify ZIKV-infected pregnant women. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.008DOI Listing
February 2019

Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats.

Reprod Toxicol 2019 Feb 13. Epub 2019 Feb 13.

Department of pharmacology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, Wuhan 430071, China. Electronic address:

Hepatic and pulmonary toxicity in fetal rats induced by pyrrolizidine alkaloids (PAs) was investigated. Retrorsine (RTS) or monocrotaline (MCT) was intragastrically administered during pregnancy. The reduction of body and tail lengths was consistent with body weight loss in PA-exposed fetuses, and pathological lesions in liver and lung were observed only in fetuses. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.02.006DOI Listing
February 2019

Prenatal cannabinoid exposure and altered neurotransmission.

Neuropharmacology 2019 Feb 13. Epub 2019 Feb 13.

Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA. Electronic address:

Marijuana is one of the most commonly used illicit drugs worldwide. In addition, use of synthetic cannabinoids is increasing, especially among adolescents and young adults. Although human studies have shown that the use of marijuana during pregnancy leads to adverse behavioral effects, such as deficiencies in attention and executive function in affected offspring, the rate of marijuana use among pregnant women is steadily increasing. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.018DOI Listing
February 2019

Just choice: a Danielsian analysis of the aims and scope of prenatal screening for fetal abnormalities.

Med Health Care Philos 2019 Feb 15. Epub 2019 Feb 15.

Department of Health, Ethics and Society, GROW School for Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.

Developments in Non-Invasive Prenatal Testing (NIPT) and cell-free fetal DNA analysis raise the possibility that antenatal services may soon be able to support couples in non-invasively testing for, and diagnosing, an unprecedented range of genetic disorders and traits coded within their unborn child's genome. Inevitably, this has prompted debate within the bioethics literature about what screening options should be offered to couples for the purpose of reproductive choice. In relation to this problem, the European Society of Human Genetics (ESHG) and American Society of Human Genetics (ASHG) tentatively recommend that any expansion of this type of screening, as facilitated by NIPT, should be limited to serious congenital and childhood disorders. Read More

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http://dx.doi.org/10.1007/s11019-019-09888-5DOI Listing
February 2019

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries.

Arch Gynecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: To estimate the impact of increasing pre-pregnancy Body Mass Index (BMI) on the risk of adverse maternal and perinatal outcomes, in patients who delivered in an Italian tertiary care Obstetric department.

Methods: Data, related to women who delivered at Sant'Anna Hospital, Turin, between 2011 and 2015, were collected retrospectively from the hospital database. According to BMI, women were considered as normal weight, overweight, and class 1, 2 and 3 obese (WHO criteria). Read More

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http://dx.doi.org/10.1007/s00404-019-05093-0DOI Listing
February 2019
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Screening for substance use in pregnancy and the newborn.

Semin Fetal Neonatal Med 2019 Feb 5. Epub 2019 Feb 5.

Department Obstetrics & Gynecology and Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

Substance use during pregnancy is common, costly and associated with maternal and newborn health consequences. Assessment of substance use should be integrated into prenatal care. Substance use identification methods include patient interview, screening instruments, and biological testing. Read More

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http://dx.doi.org/10.1016/j.siny.2019.01.007DOI Listing
February 2019

Management of fetal tumors.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 14. Epub 2019 Jan 14.

Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada. Electronic address:

In this review article, we discuss the most common fetal tumors, their prenatal management, and outcomes. Overall, the most important outcome predictors are tumor histology, size, vascularity, and location. Very large lesions, lesions causing cardiac failure, and hydrops and lesions obstructing the fetal airway have the poorest outcome, as they may cause fetal death or complications at the time of delivery. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.006DOI Listing
January 2019
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Hospital Variation in Child Protection Reports of Substance Exposed Infants.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, University of Washington School of Public Health, Seattle, WA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA; Harborview Injury Prevention & Research Center, University of Washington, Seattle, WA.

Objective: To examine whether hospital-level factors contribute to discrepancies in reporting to Child Protective Services (CPS) of infants diagnosed with prenatal substance exposure.

Study Design: We used a linked dataset of birth, hospital, and CPS records using diagnostic codes (International Classification of Diseases, Ninth Revision) to identify infants diagnosed with prenatal substance exposure. Using multilevel models, we examined hospital-level and individual birth-level factors in relation to a report to CPS among those infants prenatally exposed to substances. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476193000
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http://dx.doi.org/10.1016/j.jpeds.2018.12.065DOI Listing
February 2019
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Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.

Brain Res Bull 2019 Feb 12;147:36-46. Epub 2019 Feb 12.

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, India; CNS Pharmacology, Conscience Research, Delhi, India. Electronic address:

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with two major behavioral symptoms i.e. repetitive behavior and social-communication impairment. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.003DOI Listing
February 2019

Establishment of partner preference in male rats: Effect of prenatal letrozole and sexual experience.

Horm Behav 2019 Feb 19;109:56-63. Epub 2019 Feb 19.

Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, México. Electronic address:

Repeated testing for masculine sexual behavior influences female sex preference in males. Males perinatally treated with aromatase inhibitors show male preference, but also copulate with the receptive female. Such copulation modifies sex preference most likely because of its rewarding properties. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.02.009DOI Listing
February 2019

Reproductive Health Outcomes in African Refugee Women: A Comparative Study.

J Womens Health (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

4 Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts.

Background: African refugee women in the United States are at risk of poor reproductive health outcomes; however, examination of reproductive health outcomes in this population remains inadequate. We compared: (1) prepregnancy health and prenatal behavior; (2) prenatal history and prenatal care utilization; and (3) labor and birth outcomes between African refugee women and U.S. Read More

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http://dx.doi.org/10.1089/jwh.2018.7314DOI Listing
February 2019