153,900 results match your criteria Journal of Prenatal & Perinatal Psychology & Health [Journal]


Long term effects of chronic prenatal exposure to hypercarbia on organ growth and cardiovascular responses to adrenaline and hypoxia in common snapping turtles.

Comp Biochem Physiol A Mol Integr Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Biological Sciences, Developmental Integrative Biology Cluster, University of North Texas, Denton, TX 76203-5220, USA. Electronic address:

Reptilian embryos often face challenging environmental gas compositions during incubation, which may inflict long lasting effects in the individuals' physiological responses. These conditions can have a lasting effect on the animal into juvenile life as chronic prenatal exposure to hypercarbia results in enlarged hatchling organ size, higher growth rate and resting metabolic rate, although relatively smaller increment in metabolic scope during digestion. Therefore, we wanted to verify whether prenatal hypercarbia exposure would cause persistent effects on morphology and physiological responses in C. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10956433193000
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http://dx.doi.org/10.1016/j.cbpa.2019.04.009DOI Listing
April 2019
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Liver-derived Cell-free Nucleic Acids in Plasma: Biology and Applications in Liquid Biopsies.

J Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China; State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China. Electronic address:

There is much global research interest into the use of cell-free DNA (cfDNA) for liquid biopsies. cfDNA-based noninvasive prenatal testing (NIPT) for fetal chromosomal aneuploidies was the first success in using cfDNA technology to profoundly transform clinical practice, and has been rapidly adopted in dozens of countries and used by millions of pregnant women every year. Prompted by such developments, efforts to use cfDNA for other fields, especially for cancer detection and monitoring have been actively pursued in recent years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193025
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http://dx.doi.org/10.1016/j.jhep.2019.04.003DOI Listing
April 2019
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The association between prenatal exposure to phthalates and cognition and neurobehavior of children-evidence from birth cohorts.

Neurotoxicology 2019 Apr 17. Epub 2019 Apr 17.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Electronic address:

Background: Phthalate have been detected widely in the environment; while several studies have indicated that prenatal phthalate exposure has adverse effects on neurodevelopment, the results were inconsistent.

Objective: We aimed to determine the current research status of the relationship between prenatal exposure to different types of phthalate and cognition and behavioral development in children. We conducted a systematic review to evaluate the current state of knowledge. Read More

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http://dx.doi.org/10.1016/j.neuro.2019.04.007DOI Listing

Resveratrol Treatment Ameliorates Leptin Resistance and Adiposity Programmed by the Combined Effect of Maternal and Post-Weaning High-Fat Diet.

Mol Nutr Food Res 2019 Apr 20:e1801385. Epub 2019 Apr 20.

H.-R. Yu, J.-M. Sheen, M.-M. Tiao, Y.-L. Tain, C.-C. Chen, I.-C. Lin, L.-T. Huang, Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Objective: Prenatal high fat (HF) and postnatal HF diet are both associated with obesity and metabolic disturbances in adults. Leptin resistance induced by obesity limits its biological effects. The anti-obesity mechanism of resveratrol in visceral adiposity was investigated here. Read More

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http://dx.doi.org/10.1002/mnfr.201801385DOI Listing

Noninvasive prenatal testing for fetal subchromosomal copy number variations and chromosomal aneuploidy by low-pass whole-genome sequencing.

Mol Genet Genomic Med 2019 Apr 19:e674. Epub 2019 Apr 19.

Annoroad Gene Technology Co., Ltd, Beijing, China.

Background: Expanding noninvasive prenatal testing (NIPT) to include the detection of fetal subchromosomal copy number variations (CNVs) significantly decreased the sensitivity and specificity. Developing analytic pipeline to achieve high performance in the noninvasive detection of CNVs will largely contribute to the application of CNVs screening in clinical practice.

Methods: We developed the Noninvasively Prenatal Subchromosomal Copy number variation Detection (NIPSCCD) method based on low-pass whole-genome sequencing, and evaluated its efficacy in detecting fetal CNVs and chromosomal aneuploidies with 20,003 pregnant women. Read More

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http://dx.doi.org/10.1002/mgg3.674DOI Listing

The Kansas University DHA Outcomes Study (KUDOS) clinical trial: long-term behavioral follow-up of the effects of prenatal DHA supplementation.

Am J Clin Nutr 2019 Apr 20. Epub 2019 Apr 20.

Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS.

Background: Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid that has been linked to improved vision and cognition in postnatal feeding studies and has been consistently associated with reduction of early preterm birth in prenatal supplementation trials. This is a report of the first long-term follow-up of infants from mothers receiving prenatal DHA supplementation in a US cohort.

Objective: Our objective was to evaluate the efficacy of the prenatal supplementation on both global and granular longitudinal assessments of cognitive and behavioral development. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqz018DOI Listing
April 2019
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Smoke-Free Moms: Financial Rewards for Smoking Cessation by Low-Income Rural Pregnant Women.

Am J Prev Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Community and Family Medicine, Dartmouth Geisel School of Medicine, Hanover, New Hampshire.

Introduction: Maternal smoking places the child at risk during pregnancy and postpartum. Most women who quit smoking do so early when they first learn of pregnancy. Few low-income women quit once they enter prenatal care. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07493797193008
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http://dx.doi.org/10.1016/j.amepre.2019.02.008DOI Listing
April 2019
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Pfeiffer Syndrome Type 3 and Prune Belly Anomaly in a Female: Case Report and Review.

Fetal Pediatr Pathol 2019 Apr 19:1-6. Epub 2019 Apr 19.

a Center for Registry and Research in Congenital Anomalies (CRIAC), Service of Genetics and Cytogenetics Unit, Pediatrics Division, Dr. Juan I. Menchaca Civil Hospital of Guadalajara , Guadalajara , Jalisco , Mexico.

Background: Pfeiffer syndrome (PS) is an autosomal dominant entity characterized by craniosynostosis, broad thumbs, and preaxially deviated great toes. It is classified in three types depending on the severity. Type 1: Mild to moderate severity, Type 2: Severe presentation with cloverleaf skull, and Type 3: Severe craniosynostosis with prominent ocular proptosis. Read More

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https://www.tandfonline.com/doi/full/10.1080/15513815.2019.1
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http://dx.doi.org/10.1080/15513815.2019.1603256DOI Listing
April 2019
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A Predictive Model of Postnatal Surgical Intervention in Children With Prenatally Detected Congenital Anomalies of the Kidney and Urinary Tract.

Front Pediatr 2019 2;7:120. Epub 2019 Apr 2.

Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands.

The aim of this study was to identify predictive factors and develop a model to assess individualized risk of postnatal surgical intervention in patients with antenatal hydronephrosis. This is a retrospective cohort study of 694 infants with prenatally detected congenital anomalies of kidney and urinary tract with a median follow-up time of 37 months. The main event of interest was postnatal surgical intervention. Read More

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http://dx.doi.org/10.3389/fped.2019.00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454042PMC
April 2019
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Effectiveness of Prenatal Intervention on the Outcome of Diseases That Have a Postnatal Urological Impact.

Front Pediatr 2019 2;7:118. Epub 2019 Apr 2.

Department of Urology, Charité Medical University of Berlin, Berlin, Germany.

We reviewed the literature addressing outcomes of fetal intervention of conditions that require post-natal urological management including lower urinary tract obstruction, hydrometrocolpos, congenital adrenal hyperplasia, and myelomeningocele. Despite several decades of fetal intervention for these conditions, benefits remain elusive in part because of the enormous difficulty of conducting prospective randomized studies. In this review, we reached the following conclusions: Prenatal intervention in lower urinary tract obstruction (LUTO) improves survival in the worst cases by improving pulmonary function and it may be advantageous for renal function, particularly in patients with adverse urine parameters. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00118/
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http://dx.doi.org/10.3389/fped.2019.00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454137PMC
April 2019
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Transport, Metabolism, and Function of Thyroid Hormones in the Developing Mammalian Brain.

Front Endocrinol (Lausanne) 2019 3;10:209. Epub 2019 Apr 3.

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Ever since the discovery of thyroid hormone deficiency as the primary cause of cretinism in the second half of the 19th century, the crucial role of thyroid hormone (TH) signaling in embryonic brain development has been established. However, the biological understanding of TH function in brain formation is far from complete, despite advances in treating thyroid function deficiency disorders. The pleiotropic nature of TH action makes it difficult to identify and study discrete roles of TH in various aspect of embryogenesis, including neurogenesis and brain maturation. Read More

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http://dx.doi.org/10.3389/fendo.2019.00209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456649PMC

CXCR2 Blockade Mitigates Neural Cell Injury Following Preclinical Chorioamnionitis.

Front Physiol 2019 2;10:324. Epub 2019 Apr 2.

Department of Pediatrics, School of Medicine, The University of New Mexico, Albuquerque, NM, United States.

Minimizing central nervous system (CNS) injury from preterm birth depends upon identification of the critical pathways that underlie essential neurodevelopmental and CNS pathophysiology. While chorioamnionitis (CHORIO), is a leading cause of preterm birth, the precise mechanism linking prenatal brain injury and long-term CNS injury is unknown. The chemokine (C-X-C motif) ligand 1 (CXCL1) and its cognate receptor, CXCR2, are implicated in a variety of uterine and neuropathologies, however, their role in CNS injury associated with preterm birth is poorly defined. Read More

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http://dx.doi.org/10.3389/fphys.2019.00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454349PMC

Antenatal Hypoxia and Programming of Glucocorticoid Receptor Expression in the Adult Rat Heart.

Front Physiol 2019 2;10:323. Epub 2019 Apr 2.

Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Glucocorticoid receptor (GR) signaling is critical for development and function of the heart. Our previous study demonstrated that gestational hypoxia induced epigenetic repression of the GR gene in the developing heart. The present study aims to determine that the alterations of promoter methylation level and epigenetic repression of the GR gene in the developing heart in response to maternal hypoxia is sustained in adult offspring and potential gender differences in the programming of GR gene. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00323
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http://dx.doi.org/10.3389/fphys.2019.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454194PMC
April 2019
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Prenatal Treatment of X-Linked Hypohidrotic Ectodermal Dysplasia using Recombinant Ectodysplasin in a Canine Model.

J Pharmacol Exp Ther 2019 Apr 18. Epub 2019 Apr 18.

University of Pennsylvania;

X-linked hypohidrotic ectodermal dysplasia (XLHED) is caused by defects in the EDA gene that inactivate the function of ectodysplasin A (EDA1). This leads to abnormal development of eccrine glands, hair follicles and teeth, and to frequent respiratory infections. Previous studies in the naturally occurring dog model demonstrated partial prevention of the XLHED phenotype by postnatal administration of recombinant ectodysplasin (Fc:EDA1; EDI200). Read More

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http://dx.doi.org/10.1124/jpet.118.256040DOI Listing

Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study.

Ital J Pediatr 2019 Apr 18;45(1):50. Epub 2019 Apr 18.

Department of Women's Health, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, People's Republic of China.

Background: Congenital anomalies of the kidney and urinary tract (CAKUTs) are some of the most common birth defects affecting newborns. CAKUTs often have poor birth outcomes owing to the limited experience of physicians in developing countries regarding antenatal and postnatal diagnosis. We aimed to estimate the epidemiology of CAKUTs using data from a hospital-based registry in Zhejiang Province, China. Read More

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http://dx.doi.org/10.1186/s13052-019-0635-9DOI Listing

Sero-epidemiological status and risk factors of toxoplasmosis in pregnant women in Northern Vietnam.

BMC Infect Dis 2019 Apr 18;19(1):329. Epub 2019 Apr 18.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Background: In Vietnam, few studies have determined the epidemiological status of toxoplasmosis in pregnant women and no routine prenatal screening is in place. This study was conducted to evaluate the seroprevalence of this zoonotic parasitic infection in pregnant women in Northern Vietnam and to assess the association with awareness, risk factors and congenital toxoplasmosis.

Methods: Approximately 800 pregnant women were included in the study from two hospitals, one in Hanoi and one in Thai Binh province, which is known to have a dense cat population. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3885-7DOI Listing
April 2019
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Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study.

Dev Neurosci 2019 Apr 18:1-12. Epub 2019 Apr 18.

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA,

Prenatal ethanol exposure alters brain structure, functional connectivity, and behavior in humans and rats. Behavioral changes include deficits in executive function, which requires cooperative activity between the frontal cortices and other brain regions. In this study, we analyzed the functional connectivity and neurochemical levels of the prefrontal cortex (PFC) using resting-state functional magnetic resonance imaging (rsfMRI) and proton magnetic resonance spectroscopy (1H-MRS) in ethanol-exposed (Eth) and control (Ctr) rats. Read More

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http://dx.doi.org/10.1159/000499183DOI Listing

Economic evaluation of California prenatal participation in the special supplemental nutrition program for Women, Infants and Children (WIC) to prevent preterm birth.

Prev Med 2019 Apr 15. Epub 2019 Apr 15.

Research and Evaluation Unit, Public Health Foundation Enterprises- Special Supplemental Nutrition Program for Women, Infants and Children (PHFE WIC), 12781 Schabarum Ave., Irwindale, CA 91706.

There is growing evidence that prenatal participation in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) reduces the risk of adverse birth outcomes. With recent changes in health care, rising health care costs, and increasing rates of prematurity in the U.S. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.04.011DOI Listing

A gradual change of chromosome mosaicism from placenta to fetus leading to T18 false negative result by NIPS.

Clin Chim Acta 2019 Apr 15. Epub 2019 Apr 15.

Department of Prenatal Diagnosis, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, China. Electronic address:

Background: Noninvasive prenatal screening (NIPS) has higher sensitivity and specificity compared to traditional prenatal screening. Nevertheless, the discordant results between the NIPS and prenatal diagnosis were occasionally reported. In current study, we investigated the genetic basis of a T18 fetus with a discordant trisomy 5 (T5) positive and trisomy 18 (T18) negative NIPS result. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.064DOI Listing

Predictors of severe intraventricular hemorrhage in preterm infants under 29-weeks gestation.

J Matern Fetal Neonatal Med 2019 Apr 17:1-6. Epub 2019 Apr 17.

d Division of Neonatology , Department of Pediatrics, University of Minnesota , Minneapolis , MN , USA.

Purpose: Preterm infants <29 weeks of gestation are at risk for severe intraventricular hemorrhage (IVH). Lower gestational age, birth weight, severe illness, as indexed by higher Score for Neonatal Acute Physiology - Perinatal Extension II (SNAPPE-II) are associated with severe IVH. The role of coagulation abnormalities on the first day after birth in severe IVH remains controversial. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1601698DOI Listing
April 2019
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Digital vs face-to-face information provision in patient counselling for prenatal screening: a noninferiority randomized controlled trial.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

VU University Amsterdam, Athena Institute for Trans-Disciplinary Research, the Netherlands.

Objective: To evaluate face-to-face information provision in patient counselling for prenatal screening compared to two forms of digital information provision, namely non-interactive instructional video or interactive video.

Method: We performed a prospective, non-inferiority, cluster-randomized controlled trial comparing face-to-face (usual care) to two forms of digital information provision (intervention) in counselling for prenatal screening. This study was performed in the Amsterdam UMC, the Netherlands in 2017, and included women in the first trimester of pregnancy. Read More

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http://dx.doi.org/10.1002/pd.5463DOI Listing

Identification of novel and rare CYP21A2 variants in Chinese patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

Authors:
Jing Xu Pin Li

Clin Biochem 2019 Apr 14. Epub 2019 Apr 14.

Department of Endocrinology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China. Electronic address:

Objective: 21-hydroxylase deficiency (21-OHD) is the most common cause of congenital adrenal hyperplasia due to CYP21A2 gene mutation. The aim of study is to expand CYP21A2 mutational spectrum in the Chinese population and to provide novel genetic information in terms of ethnic diversity.

Design And Methods: 95 Chinese suspected 21-OHD patients with phenotypes varying from salt-wasting (SW) to nonclassic symptoms were recruited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00099120183137
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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.008DOI Listing
April 2019
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Metabolic Fingerprinting of Chorionic Villous Samples in Normal Pregnancy and Chromosomal Disorders.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy, Ospedale Pediatrico Microcitemico A.Cao, Cagliari, Italy.

Objective: Placenta-related biological samples are used in biomedical research to investigate placental development. Metabolomics represents a promising approach for studying placental metabolism in an effort to explain physiological and pathological mechanisms. The aim of this study was to investigate metabolic changes in chorionic villi during the first trimester of pregnancy in euploid and aneuploid cases. Read More

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http://dx.doi.org/10.1002/pd.5461DOI Listing

Maternal Cell Phone Use During Pregnancy, Pregnancy Duration And Fetal Growth In Four Birth Cohorts.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Previous studies evaluating potential effects of prenatal exposure to radiofrequency fields from cell phones on birth outcomes are inconsistent. We explored if maternal cell phone use was associated with pregnancy duration and fetal growth. We used information from 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008) and Korea (2006-2011). Read More

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http://dx.doi.org/10.1093/aje/kwz092DOI Listing
April 2019
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Violence and sexually transmitted infections in pregnancy.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):475-484. Epub 2019 Apr 11.

Department of Post-Graduation in Medical Sciences, University of the State of Rio de Janeiro, Rio de Janeiro, Brasil.

Objective: To synthesize the knowledge produced in studies about the association between violence and STI during pregnancy.

Methods: In this systematic review, we conducted basic activities of identification, compilation, and registration of the trials. The instruments of data collection were studies that investigated, explicitly, relationships between violence, gestation, and STI, from July 2012 to July 2017, using PubMed, Cochrane Library, SciELO, and LILACS. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.475DOI Listing

Comparison of the LIAISON®XL and ARCHITECT IgG, IgM, and IgG avidity assays for the diagnosis of Toxoplasma, cytomegalovirus, and rubella virus infections.

New Microbiol 2019 Apr 17;41(2). Epub 2019 Apr 17.

SC Microbiologia e Virologia Fondazione IRCCS Policlinico San Matteo Pavia, Italy.

This study compared the performance of the LIAISON®XL system of immunoglobulin (Ig) G and IgM immunoassays for the diagnosis of Toxoplasma gondii, cytomegalovirus (CMV), and rubella virus infections with that of the ARCHITECT system. Patient serum samples, previously screened and clinically diagnosed with T. gondii, CMV or rubella, were used to compare LIAISON®XL and ARCHITECT IgG and IgM immunoassays. Read More

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Enhancing Accessibility of Physical Activity During Pregnancy: A Pilot Study on Women's Experiences With Integrating Yoga Into Group Prenatal Care.

Health Serv Res Manag Epidemiol 2019 Jan-Dec;6:2333392819834886. Epub 2019 Apr 4.

Division of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, USA.

Introduction: Health guidelines suggest that pregnant women should participate in daily physical activity, yet rarely do they meet these guidelines. Means to enhance accessibility of physical activity for pregnant women are required, and yoga has been suggested as a possible method to enhance women's sense of confidence and competence with physical activity. In this pilot study, our primary aim is to evaluate pregnant women's perceptions about their lived experience of an intervention which integrates a low-intensity form of physical activity, yoga, into prenatal care; our secondary aim is to evaluate changes in participants' self-efficacy for physical activity and time spent in physical activity over time. Read More

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http://dx.doi.org/10.1177/2333392819834886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449809PMC

Informational needs of pregnant women following the prenatal diagnosis of fetal anomalies: A qualitative study in Iran.

J Educ Health Promot 2019 15;8:30. Epub 2019 Feb 15.

Department of Health Sciences, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: An appropriate exchange of information between the health-care provider and the family is an important component of coping with stress following the prenatal diagnosis of fetal anomalies. Therefore, this study was conducted to explore the informational needs of pregnant women following a prenatal diagnosis of fetal anomalies in Mashhad, Iran.

Subjects And Methods: This qualitative, conventional, content analysis study was designed through two referral centers for fetal anomaly. Read More

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http://dx.doi.org/10.4103/jehp.jehp_199_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432835PMC
February 2019

Gene discovery informatics toolkit defines candidate genes for unexplained infertility and prenatal or infantile mortality.

NPJ Genom Med 2019 15;4. Epub 2019 Apr 15.

1Kids Neuroscience Centre, Kids Research, Children's Hospital at Westmead, Sydney, NSW 2145 Australia.

Despite a recent surge in novel gene discovery, genetic causes of prenatal-lethal phenotypes remain poorly defined. To advance gene discovery in prenatal-lethal disorders, we created an easy-to-mine database integrating known human phenotypes with inheritance pattern, scores of genetic constraint, and murine and cellular knockout phenotypes-then critically assessed defining features of known prenatal-lethal genes, among 3187 OMIM genes, and relative to 16,009 non-disease genes. While around one-third (39%) of protein-coding genes are essential for murine development, we curate only 3% (624) of human protein-coding genes linked currently to prenatal/infantile lethal disorders. Read More

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http://dx.doi.org/10.1038/s41525-019-0081-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465277PMC
April 2019
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Aberrant DNA methylation as a diagnostic biomarker of diabetic embryopathy.

Genet Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Purpose: Maternal diabetes is a known teratogen that can cause a wide spectrum of birth defects, collectively referred to as diabetic embryopathy (DE). However, the pathogenic mechanisms underlying DE remain uncertain and there are no definitive tests to establish the diagnosis. Here, we explore the potential of DNA methylation as a diagnostic biomarker for DE and to inform disease pathogenesis. Read More

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http://www.nature.com/articles/s41436-019-0516-z
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http://dx.doi.org/10.1038/s41436-019-0516-zDOI Listing
April 2019
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Knowledge of vesicoureteral reflux obtained by screening voiding cystourethrogram in children with multicystic dysplastic kidney does not change patient management or prevent febrile urinary tract infection.

J Pediatr Urol 2019 Mar 22. Epub 2019 Mar 22.

Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Introduction: While children with multicystic dysplastic kidneys (MCDK) are predisposed to contralateral kidney (CK) vesicoureteral reflux (VUR), it is unknown if this results in an increased risk of urinary tract infection (UTI). The authors hypothesized that knowledge of VUR via voiding cystourethrogram (VCUG) would enable altered practices to prevent UTI and thus reduce the number of febrile urinary tract infections (fUTIs).

Methods: The authors performed a retrospective chart review of all patients at their institution of multiple providers caring for patients with a diagnosis of MCDK from 1/1/07 to 7/14/17. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.03.013DOI Listing
March 2019
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Maternal half-sibling families with discordant fathers: a contrastive design assessing cross-generational paternal genetic transmission of alcohol use disorder, drug abuse and major depression.

Psychol Med 2019 Apr 17:1-8. Epub 2019 Apr 17.

Center for Primary Health Care Research, Lund University,Malmö,Sweden.

Background: We introduce and apply an elegant, contrastive genetic-epidemiological design - Maternal Half-Sibling Families with Discordant Fathers - to clarify cross-generational transmission of genetic risk to alcohol use disorder (AUD), drug abuse (DA) and major depression (MD).

Method: Using Swedish national registries, we identified 73 108 eligible pairs of reared together maternal half-siblings and selected those whose biological fathers were discordant for AUD, DA and MD, and had minimal contact with the affected father. We examined differences in outcome in half-siblings with an affected v. Read More

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http://dx.doi.org/10.1017/S0033291719000874DOI Listing
April 2019
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A gestational vulnerability window for smoking exposure and the increased risk of preterm birth: how timing and intensity of maternal smoking matter.

Reprod Health 2019 Apr 16;16(1):43. Epub 2019 Apr 16.

School of Public Health, Department of Family Science, University of Maryland, 4200 Valley Drive, College Park, MD, 20742, USA.

Background: Reducing the incidence of preterm birth is a national priority. Maternal cigarette smoking is strongly and consistently associated with preterm birth. The objective of this study was to examine prenatal exposure based on combined measures of timing (by trimester) and intensity level (the number of cigarettes smoked per day) of maternal smoking to identify a pregnancy period with the highest risk of preterm birth. Read More

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https://reproductive-health-journal.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s12978-019-0705-xDOI Listing
April 2019
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Hepatic DNA methylation and expression profiles under prenatal restricted diet in three generations of female rat fetuses.

PLoS One 2019 16;14(4):e0215471. Epub 2019 Apr 16.

Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Wojska Polskiego, Poznan, Poland.

The nutritional factors acting during early life can affect the development of the organism. It has been hypothesized that such programmed traits can be inherited by later generations. In this work, we present for the first time the effect of food deprivation in pregnant dams and its consequences for the transcription and DNA methylation profiles in the offspring of the next three generations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215471PLOS
April 2019
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No time, no money, no luck: Barriers to prenatal care among dalit women in rural Nepal.

Health Care Women Int 2019 Apr 16:1-17. Epub 2019 Apr 16.

a Department of Sociology Social Work and Criminology , Idaho State University , Pocatello , ID , USA.

In Nepal, a large gap exists between non-dalit and dalit women in regard to maternal mortality and prenatal care. Especially rural Dalits are far behind non-dalits in utilizing prenatal care. We explored rural dalit women's prenatal practices and barriers to accessing prenatal care. Read More

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http://dx.doi.org/10.1080/07399332.2019.1597366DOI Listing
April 2019
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The Problem of Spontaneous Abortion: Is the Pro-Life Position Morally Monstrous?

New Bioeth 2019 Apr 16:1-18. Epub 2019 Apr 16.

b School of Health and Social Care , London South Bank University , London , UK.

A substantial proportion of human embryos spontaneously abort soon after conception, and ethicists have argued this is problematic for the pro-life view that a human embryo has the same moral status as an adult from conception. Firstly, if human embryos are our moral equals, this entails spontaneous abortion is one of humanity's most important problems, and it is claimed this is absurd, and a reductio of the moral status claim. Secondly, it is claimed that pro-life advocates do not act as if spontaneous abortion is important, implying they are failing to fulfill their moral obligations. Read More

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http://dx.doi.org/10.1080/20502877.2019.1602376DOI Listing
April 2019
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High prevalence of benign mammary tumors in a rat model of polycystic ovary syndrome during postmenopausal period.

Gynecol Endocrinol 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. Significant associations between PCOS and benign breast diseases (BBD) and a possibly potential association between PCOS and breast cancer have been reported. The etiology of these events of mammary glands in PCOS remains unclear. Read More

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http://dx.doi.org/10.1080/09513590.2019.1576613DOI Listing
April 2019
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A case-control analysis of maternal diet and risk of neural tube defects in Bangladesh.

Birth Defects Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.

Objectives: Mothers need a nutrient-rich diet for healthy neural tube development. Neural tube defect risk can be reduced through fortifying grain products with folic acid and taking folic acid supplements. Fortification is not required in Bangladesh. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/bdr2.1505
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http://dx.doi.org/10.1002/bdr2.1505DOI Listing
April 2019
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Gap Junction Protein Beta 2 Gene Variants and Non-Syndromic Hearing Impairment among Couples Referred For Prenatal Diagnosis in the Northeast of Iran.

Iran J Otorhinolaryngol 2019 Mar;31(103):109-113

Department of Genetic, Academic Center for Education, Culture and Research (ACECR)-Khorasan Razavi, Mashhad, Iran.

Introduction: Hearing impairment is a complex medical disorder which has genetic and non-genetic causes. Gap Junction Protein Beta 2 (GJB2) gene variant is a well-known disease-causing gene among patients with hearing impairment. The frequencies of genetic variants in the GJB2 gene are different in each population. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449530PMC

The Effect of a Self-Efficacy-Enhancing Intervention on Perceived Self-Efficacy and Actual Adherence to Healthy Behaviours Among Women with Gestational Diabetes Mellitus.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e513-e519. Epub 2019 Mar 28.

School of Nursing, University of California, Los Angeles, California, USA.

Objectives: This study aimed to evaluate the effectiveness of a self-efficacy-enhancing intervention (SEEI) on perceived self-efficacy and actual adherence to healthy behaviours among women with gestational diabetes mellitus (GDM).

Methods: This comparative pre-post study was conducted at the Antenatal Clinic of the Sultan Qaboos University Hospital, Muscat, Oman, between October 2016 and January 2017. A total of 90 adult Omani women with GDM were randomised to either a control group receiving standard prenatal care or a SEEI group. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443280PMC
November 2018

Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats.

Sci Rep 2019 Apr 15;9(1):6062. Epub 2019 Apr 15.

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, School of Medicine, University of Catania, Catania, Italy.

Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow in individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. Read More

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http://dx.doi.org/10.1038/s41598-019-42532-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465353PMC
April 2019
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Systematic assessment of the sex ratio at birth for all countries and estimation of national imbalances and regional reference levels.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003-9304.

The sex ratio at birth (SRB; ratio of male to female live births) imbalance in parts of the world over the past few decades is a direct consequence of sex-selective abortion, driven by the coexistence of son preference, readily available technology of prenatal sex determination, and fertility decline. Estimation of the degree of SRB imbalance is complicated because of unknown SRB reference levels and because of the uncertainty associated with SRB observations. There are needs for reproducible methods to construct SRB estimates with uncertainty, and to assess SRB inflation due to sex-selective abortion. Read More

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http://dx.doi.org/10.1073/pnas.1812593116DOI Listing

Climate change and educational attainment in the global tropics.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Department of Geography, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Climate change may negatively impact education among children via exposure to extreme temperature and precipitation conditions. We link census data from 29 countries across the global tropics to high-resolution gridded climate data to understand how climatic conditions experienced in utero and during early childhood affect educational attainment at ages 12 to 16. We show that exposure to higher-than-average temperatures during the prenatal and early-life period is associated with fewer years of schooling in Southeast Asia. Read More

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http://dx.doi.org/10.1073/pnas.1817480116DOI Listing
April 2019
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Trisomy 21 in both fetuses in a DCDA twin pregnancy.

BMJ Case Rep 2019 Apr 14;12(4). Epub 2019 Apr 14.

Obstetrics and Gynecology, National University Hospital, Singapore.

A woman's chances of having a child with Down syndrome increases with age. By age 40, the risk of conceiving a child with Down syndrome is about 1 in 100. We report a rare case of dizygotic dichorionic diamniotic twin pregnancy conceived via in vitro fertilisation, with both twins having trisomy 21. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22760
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http://dx.doi.org/10.1136/bcr-2018-227608DOI Listing
April 2019
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Reactivating endogenous mechanisms of cardiac regeneration via paracrine boosting using the human amniotic fluid stem cell secretome.

Int J Cardiol 2019 Apr 4. Epub 2019 Apr 4.

Regenerative Medicine Laboratory, Department of Experimental Medicine, University of Genova, Genova, Italy. Electronic address:

Background: The adult mammalian heart retains residual regenerative capability via endogenous cardiac progenitor cell (CPC) activation and cardiomyocyte proliferation. We previously reported the paracrine cardioprotective capacity of human amniotic fluid-derived stem cells (hAFS) following ischemia or cardiotoxicity. Here we analyse the potential of hAFS secretome fractions for cardiac regeneration and future clinical translation. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.04.011DOI Listing

ACTA1-myopathy with prominent finger flexor weakness and rimmed vacuoles.

Neuromuscul Disord 2019 Mar 2. Epub 2019 Mar 2.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

Actinopathy is a group of clinically and pathologically heterogeneous myopathies due to mutations in the skeletal muscle sarcomeric α-actin 1-encoding gene (ACTA1). Disease-onset spans from prenatal life to adulthood and weakness can preferentially affect proximal or distal muscles. Myopathological findings include a spectrum of structural abnormalities with nemaline rods being the most common. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608966183127
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http://dx.doi.org/10.1016/j.nmd.2019.02.012DOI Listing
March 2019
3 Reads

Association of CYP19A1 single-nucleotide polymorphism with digit ratio (2D:4D) in a sample of men and women from Ningxia (China).

Early Hum Dev 2019 Apr 12;132:58-65. Epub 2019 Apr 12.

School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, China; Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia 750004, China. Electronic address:

Objectives: 2D:4D is an anthropometric indicator that may reflect the level of intrauterine sexual hormone exposure before birth. The aromatase gene (CYP19A1) mainly encodes cytochrome P450 aromatase, a key enzyme that catalyzes the conversion of androgens to estrogens in vivo and affects the development of 2D:4D. Studying the association between six single-nucleotide polymorphisms (SNPs) in CYP19A1 and digit ratios in the normal population of China will provide some basis for the biological basis of digit ratio development and promote the practical application of digit ratios. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183068
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http://dx.doi.org/10.1016/j.earlhumdev.2019.04.004DOI Listing
April 2019
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Maternal manipulation during late gestation (GDs 17-20) enhances ethanol consumption and promotes changes and opioid mRNA expression in infant rats.

Behav Brain Res 2019 Apr 12;368:111908. Epub 2019 Apr 12.

Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, C.P. 5000, Argentina; Instituto de Investigaciones Psicológicas (IIPsi-CONICET-UNC), Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, C.P. 5000, Argentina. Electronic address:

Fetal ethanol experience generates learning and memories capable to increase ethanol consummatory behaviors during infancy. Opioid system seems to be involved in mediating those alcohol-related behaviors. In this work, we proposed to study the impact of prenatal exposure to a moderate ethanol dose, upon ingestion of the drug and possible ethanol-induced molecular changes on opioid precursor peptides (POMC, Pro-enk and Pro-DYN) and receptors (MOR, DOR and KOR) mRNA expression, in hypothalamus. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111908DOI Listing

Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice.

Brain Res 2019 Apr 12. Epub 2019 Apr 12.

School of Life Sciences, Guangzhou University, Guangzhou, 510006, China. Electronic address:

Citalopram (CTM), a selective serotonin reuptake inhibitor (SSRI), has been widely used to treat panic disorders, such as depression which is one of the most disabling, yet common, psychiatric disorders. Although prenatal antidepressant exposure has a major impact on the neurobehavioral development of the offspring, such as anxiety, depression- and autism-like behaviors, the brain alterations of SSRI influence remained largely unknown. We show here, using electrophysiological recordings, that CTM exposure during the last 7 d of gestation can alter theta- and gamma-band oscillation and synchronization in the corticostriatal loop of 2-3 month-old mouse offspring. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.008DOI Listing

Congenital Lung Malformations.

Pediatr Ann 2019 Apr;48(4):e169-e174

Congenital lung malformations (CLM) comprise a spectrum of anatomical anomalies of the lungs and respiratory tree. The prenatal growth pattern of CLMs is unpredictable with larger lesions causing life-threatening complications, such as hydrops fetalis, and smaller lesions remaining asymptomatic and potentially regressing. The most common CLMs are congenital pulmonary adenomatoid malformations, bronchopulmonary sequestrations, congenital lobar emphysema, and bronchogenic cysts. Read More

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http://dx.doi.org/10.3928/19382359-20190326-02DOI Listing
April 2019
3 Reads