3,233 results match your criteria Journal of Physiology and Biochemistry [Journal]


LINGO-1 siRNA nanoparticles promote central remyelination in ethidium bromide-induced demyelination in rats.

J Physiol Biochem 2019 Feb 13. Epub 2019 Feb 13.

Department of Medical Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.

Multiple sclerosis is among the most common causes of neurological disabilities in young adults. Over the past decade, several therapeutic strategies have emerged as having potential neuroprotective and neuroregenerative properties. We investigated the effect of intranasal administration of LINGO-1-directed siRNA-loaded chitosan nanoparticles on demyelination and remyelination processes in a rat model of demyelination. Read More

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http://dx.doi.org/10.1007/s13105-018-00660-6DOI Listing
February 2019

L-type Ca channels' involvement in IFN-γ-induced signaling in rat ventricular cardiomyocytes.

J Physiol Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow, Russia, 117997.

The purpose of this study was to examine the effects of interferon-γ (IFN-γ) on calcium movement in rat ventricular myocytes. L-type Ca currents (I) were recorded with the whole-cell configuration of the patch-clamp techniques. IFN-γ induces current density reduction at the test potential of 0 mV by 47. Read More

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http://dx.doi.org/10.1007/s13105-019-00662-yDOI Listing
February 2019

THBS4 predicts poor outcomes and promotes proliferation and metastasis in gastric cancer.

J Physiol Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, No.250 East Street, Licheng District, Quanzhou, 362000, Fujian Province, China.

Gastric cancer (GC), a common and lethal cancer in the world, has a high risk of metastasis. Our study was to explore the effects of THBS4 on GC progress and metastasis and the underlying mechanisms. The proliferations of MGC-803 and BGC-823 cells were analyzed via cell count, MTT, and soft agar colony formation assay. Read More

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http://dx.doi.org/10.1007/s13105-019-00665-9DOI Listing
February 2019

Diabetes abolish cardioprotective effects of remote ischemic conditioning: evidences and possible mechanisms.

J Physiol Biochem 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, 147002, India.

Diabetes mellitus significantly hampers the development of cardioprotective response to remote pre/post/perconditioning stimuli by impairing the activation of cardioprotective signaling pathways. Among the different pathways, the impairment in O-linked β-N-acetylglucosamine (O-GlcNAc) signaling and release of cardioprotective humoral factor may contribute in attenuating remote preconditioning-induced cardioprotection. Moreover, the failure to phosphorylate extracellular signal related kinase (ERK), phosphoinositide-3-kinase (PI3K), and AKT along with up-regulation of mechanistic target of rapamycin (mTOR) and decrease in autophagy may also attenuate remote preconditioning-induced cardioprotection. Read More

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http://dx.doi.org/10.1007/s13105-019-00664-wDOI Listing
February 2019
1 Read

Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats.

J Physiol Biochem 2019 Feb 2. Epub 2019 Feb 2.

Department of Internal Medicine, Medicine School, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.

With aging, there is a reduction in mitochondrial activity, and several changes occur in the body composition, including increased adiposity. The dysfunction of mitochondrial activity causes changes and adaptations in tissue catabolic characteristics. Among them, we can mention brown adipose tissue (BAT). Read More

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http://dx.doi.org/10.1007/s13105-019-00663-xDOI Listing
February 2019

The role of lamin A/C in mesenchymal stem cell differentiation.

J Physiol Biochem 2019 Jan 31. Epub 2019 Jan 31.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Lamin A/C is the major architectural protein of cell nucleus in charge of the nuclear mechanosensing. By integrating extracellular mechanical and biochemical signals, lamin A/C regulates multiple intracellular events including mesenchymal stem cell (MSC) fate determination. Herein, we review the recent findings about the effects and mechanisms of lamin A/C in governing MSC lineage commitment, with a special focus on osteogenesis and adipogenesis. Read More

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http://dx.doi.org/10.1007/s13105-019-00661-zDOI Listing
January 2019
1 Read

Anti-obesity effects of kaempferol by inhibiting adipogenesis and increasing lipolysis in 3T3-L1 cells.

J Physiol Biochem 2018 Dec 12. Epub 2018 Dec 12.

Facultad de Salud Pública y Nutrición, Centro de Investigación en Nutrición y Salud Pública, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo León, Mexico.

Kaempferol is a natural flavonoid widely found in fruits, vegetables, and tea. Kaempferol possesses beneficial biological properties such as anti-inflammatory and antioxidant activities. Positive energy balance during obesity correlates with a pro-inflammatory chronic state. Read More

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http://link.springer.com/10.1007/s13105-018-0659-4
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http://dx.doi.org/10.1007/s13105-018-0659-4DOI Listing
December 2018
1 Read

Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes.

J Physiol Biochem 2018 Nov 30. Epub 2018 Nov 30.

Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7A, P.O Box 5400, 90014, Oulu, Finland.

Mammalian adipose tissue is traditionally categorized into white and brown relating to their function and morphology: while white serves as an energy storage, brown adipose tissue acts as the heat generator maintaining the core body temperature. The most recently identified type of fat, beige adipocyte tissue, resembles brown fat by morphology and function but is developmentally more related to white. The synthesis of beige fat, so-called browning of white fat, has developed into a topical issue in diabetes and metabolism research. Read More

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http://dx.doi.org/10.1007/s13105-018-0658-5DOI Listing
November 2018

The protective microRNA-199a-5p-mediated unfolded protein response in hypoxic cardiomyocytes is regulated by STAT3 pathway.

J Physiol Biochem 2018 Nov 13. Epub 2018 Nov 13.

Department of High Altitude Hygiene, College of High Altitude Military Medicine, Third Military Medical University, No. 30 Gao Tan Yan Zheng Street, Sha Ping Ba District, Chongqing, 400038, People's Republic of China.

The protective effects of downregulated miR-199a-5p on ischemic and hypoxic cardiomyocytes were well recognized, but the underlying mechanism of inhibited miR-199a-5p is not yet clear. The present study explored the relationship between enhanced signal transducer and activator of transcription 3 (STAT3) signaling and lowered production of miR-199a-5p in hypoxic cardiomyocytes. This study firstly found the correlation between elevated interleukin (IL)-6 and IL-11, as well as subsequent STAT3 signaling activation and the downregulation of miR-199a-5p in hypoxic myocardial samples from children with congenital heart disease. Read More

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http://dx.doi.org/10.1007/s13105-018-0657-6DOI Listing
November 2018
3 Reads

Lipid metabolism in adipose tissue and liver from diet-induced obese rats: a comparison between Wistar and Sprague-Dawley strains.

J Physiol Biochem 2018 Nov 9;74(4):655-666. Epub 2018 Nov 9.

Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Institute, University of País Vasco (UPV/EHU), Vitoria, Spain.

Some researchers have proposed important variations in adipose tissue among different strains of rats and mice in response to a high-caloric (hc) diet, but data concerning the mechanisms underlying these differences are scarce. The aim of the present research was to characterize different aspects of triacylglycerol (TG) metabolism and clock genes between Sprague-Dawley and Wistar rats. For this purpose, 16 male Sprague-Dawley and 16 male Wistar rats were divided into four experimental groups (n = 8) and fed either a normal-caloric (nc) diet or a hc diet for 6 weeks. Read More

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http://link.springer.com/10.1007/s13105-018-0654-9
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http://dx.doi.org/10.1007/s13105-018-0654-9DOI Listing
November 2018
10 Reads

Variations in adrenal gland medulla and dopamine effects induced by the lack of Irs2.

J Physiol Biochem 2018 Nov 26;74(4):667-677. Epub 2018 Oct 26.

Department of Physiology and Pharmacology, INCyL and IBSAL, Faculty of Medicine, University of Salamanca, Avda. Alfonso X el Sabio, s/n, E-37007, Salamanca, Spain.

The adrenomedullary chromaffin cells' hormonal pathway has been related to the pathophysiology of diabetes mellitus. In mice, the deletion of insulin receptor substrate type 2 (Irs2) causes peripheral insulin resistance and reduction in β-cell mass, leading to overt diabetes, with gender differences on adrenergic signaling. To further unravel the relevance of Irs2 on glycemic control, we analyzed in adult Irs2 deficient (Irs2) mice, of both sexes but still normoglycemic, dopamine effects on insulin secretion and glycerol release, as well as their adrenal medulla by an immunohistochemical and morphologic approach. Read More

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http://link.springer.com/10.1007/s13105-018-0655-8
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http://dx.doi.org/10.1007/s13105-018-0655-8DOI Listing
November 2018
13 Reads

Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling.

J Physiol Biochem 2018 Oct 25. Epub 2018 Oct 25.

Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No.1023 South Sha-Tai Rd, Guangzhou, 510515, People's Republic of China.

Butyrate is produced by the fermentation of undigested dietary fibers and acts as the promising candidate for cancer treatment. However, the mechanism underlying sodium butyrate (NaB)-induced autophagy in colorectal cancer is not yet completely understood. The expressions of LC3-II protein and mRNA were detected by western blot and quantitative RT-PCR in colorectal cancer (CRC) cell lines HCT-116 and HT-29, respectively. Read More

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http://dx.doi.org/10.1007/s13105-018-0651-zDOI Listing
October 2018

Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice.

J Physiol Biochem 2018 Oct 25. Epub 2018 Oct 25.

Department of Health, Kinesiology & Applied Physiology, Concordia University, 7141 Sherbrooke West, Montreal, QC, H4B 1R6, Canada.

Low-carbohydrate diets are considered to be an effective approach to weight loss and have, subsequently, grown in popularity. Despite the apparent health benefits that these diets may provide for insulin resistance, hypertension, and dyslipidemia, their implications on cardiomyocyte oxidative capacity have yet to be investigated. To evaluate the adaptations induced by a 6-week low-carbohydrate, high-fat (LCHF) diet on mitochondrial respiration, two groups of male mice were investigated: Apolipoprotein E-deficient mice on a LCHF diet (L-DIET) and apolipoprotein E-deficient mice on a regular rodent diet (CON). Read More

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http://dx.doi.org/10.1007/s13105-018-0653-xDOI Listing
October 2018
7 Reads

Agaricus bisporus supplementation reduces high-fat diet-induced body weight gain and fatty liver development.

J Physiol Biochem 2018 Nov 4;74(4):635-646. Epub 2018 Oct 4.

Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3rd floor, 26006, Logroño, La Rioja, Spain.

Obesity is a global epidemic characterized not only by excessive fat deposition but also by important complications such as nonalcoholic liver steatosis. Beneficial antiobesogenic effects have been described for some mushrooms. The current study aimed to demonstrate the protective effect of Agaricus bisporus (AB) supplementation against the metabolic alterations induced by high-fat-diet (HFD) feeding. Read More

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http://link.springer.com/10.1007/s13105-018-0649-6
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http://dx.doi.org/10.1007/s13105-018-0649-6DOI Listing
November 2018
2 Reads

Hepatoprotective effect of gastrodin against alcohol-induced liver injury in mice.

J Physiol Biochem 2018 Sep 21. Epub 2018 Sep 21.

Chinese-German Joint Laboratory for Natural Product Research, College of Biological Science and Engineering, Qingling-Bashan Mountains Bioresources Comprehensive Development C.I.C, Shaanxi University of Technology, East on the 1st Ring Road, Hanzhong, 723000, Shaanxi Province, China.

Alcoholic liver disease (ALD) is a common and serious threat to human health worldwide. In this study, the hepatoprotective effect of gastrodin against alcohol-induced liver injury in mice was examined. Mice with alcohol-induced hepatotoxicity were treated intragastrically with gastrodin (50, 80, or 100 mg/kg). Read More

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http://dx.doi.org/10.1007/s13105-018-0647-8DOI Listing
September 2018
4 Reads

Diet-induced obesity and associated disorders are prevented by natural bioactive type 1 fish collagen peptides (Naticol®) treatment.

J Physiol Biochem 2018 Nov 19;74(4):647-654. Epub 2018 Sep 19.

Institut des Maladies Métaboliques et Cardiovasculaires, INSERM U1048, Université de Toulouse, UPS, Toulouse, France.

To fight against metabolic disorders such as insulin resistance, new alimentary behaviors are developed. For instance, hyperproteined, gluten-free, or collagen-enriched diets could be preconized in order to reduce the consequences of obesity. In this aim, this study evaluates the potential effects of warm sea fish collagen peptides (Naticol®) on representative metabolic and inflammatory parameters. Read More

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http://dx.doi.org/10.1007/s13105-018-0650-0DOI Listing
November 2018
7 Reads

Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats.

J Physiol Biochem 2018 Sep 17. Epub 2018 Sep 17.

Department of Cardiovascular Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710000, China.

Mitochondrial dysfunction is essential in the development and prognosis of diabetic cardiomyopathy (DCM). Resveratrol (RES) is thought as a mitochondrial protector. In this study, we hypothesized that RES may ameliorate mitochondrial function and consequently improve cardiac function in diabetic rats, and uncoupling protein 2 (UCP2) was involved in the protective effects of RES on DCM. Read More

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http://link.springer.com/10.1007/s13105-018-0648-7
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http://dx.doi.org/10.1007/s13105-018-0648-7DOI Listing
September 2018
12 Reads

Effects of branched-chain amino acids on muscles under hyperammonemic conditions.

J Physiol Biochem 2018 Nov 30;74(4):523-530. Epub 2018 Jul 30.

Department of Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03, Hradec Kralove, Czech Republic.

The aim was to determine the effects of enhanced availability of branched-chain amino acids (BCAAs; leucine, isoleucine, and valine) on ammonia detoxification to glutamine (GLN) and protein metabolism in two types of skeletal muscle under hyperammonemic conditions. Isolated soleus (SOL, slow-twitch) and extensor digitorum longus (EDL, fast-twitch) muscles from the left leg of white rats were incubated in a medium with 1 mM ammonia (NH3 group), BCAAs at four times the concentration of the controls (BCAA group) or high levels of both ammonia and BCAA (NH3 + BCAA group). The muscles from the right leg were incubated in basal medium and served as paired controls. Read More

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http://dx.doi.org/10.1007/s13105-018-0646-9DOI Listing
November 2018
1 Read

Mechanisms of the antilipolytic response of human adipocytes to tyramine, a trace amine present in food.

J Physiol Biochem 2018 Nov 23;74(4):623-633. Epub 2018 Jul 23.

INSERM U 1048 équipe 1, Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale (INSERM U1048), Université Paul Sabatier (I2MC-UPS), I2MC, Bât. L4, CHU Rangueil, BP 84225, 31432, Toulouse CEDEX 4, France.

Tyramine is found in foodstuffs, the richest being cheeses, sausages, and wines. Tyramine has been recognized to release catecholamines from nerve endings and to trigger hypertensive reaction. Thereby, tyramine-free diet is recommended for depressed patients treated with irreversible inhibitors of monoamine oxidases (MAO) to limit the risk of hypertension. Read More

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http://dx.doi.org/10.1007/s13105-018-0643-zDOI Listing
November 2018
6 Reads

Alpha-syntrophin dependent expression of tubulin alpha 8 protein in hepatocytes.

J Physiol Biochem 2018 Nov 22;74(4):511-521. Epub 2018 Jul 22.

Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.

The scaffold protein alpha-syntrophin (SNTA) is a component of the dystrophin glycoprotein complex and has been comprehensively studied in skeletal muscle and adipocytes. SNTA is further expressed in the liver where its biological role remains unclear. Unpublished data from our group suggested that SNTA deficiency is associated with altered tubulin alpha 8 (TUBA8) levels in fat. Read More

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http://link.springer.com/10.1007/s13105-018-0645-x
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http://dx.doi.org/10.1007/s13105-018-0645-xDOI Listing
November 2018
21 Reads

Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation.

J Physiol Biochem 2018 Nov 17;74(4):503-510. Epub 2018 Jul 17.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Non-alcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease. NLRP3 inflammasome activation has been widely studied in the pathogenesis of NAFLD. Cathepsin B (CTSB) is a ubiquitous cysteine cathepsin, and the role of CTSB in the progression and development of NAFLD has received extensive concern. Read More

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http://dx.doi.org/10.1007/s13105-018-0644-yDOI Listing
November 2018
7 Reads

miR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting beta galactoside alpha-2,6-sialyltransferase 1.

J Physiol Biochem 2018 Aug 13;74(3):491-501. Epub 2018 Jul 13.

School of Life Science and Medicine, Dalian University of Technology, Panjin, 122406, China.

Glycosylation of cell surface proteins regulates critical cellular functions, including invasion and metastasis in cancer cells. Emerging evidence has shown that microRNAs (miRNAs) are involved in regulating both the glycosylation modifications on cell surface and the progression of cancer. In this study, we investigated the role of miR-9 in α-2,6-linked sialylation and the metastasis of mouse hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1007/s13105-018-0642-0DOI Listing
August 2018
14 Reads
1.970 Impact Factor

FPS-ZM1 and valsartan combination protects better against glomerular filtration barrier damage in streptozotocin-induced diabetic rats.

J Physiol Biochem 2018 Aug 14;74(3):467-478. Epub 2018 Jun 14.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Despite the effectiveness of renin-angiotensin blockade in retarding diabetic nephropathy progression, a considerable number of patients still develop end-stage renal disease. The present investigation aims to evaluate the protective potential of FPS-ZM1, a selective inhibitor of receptor for advanced glycation end products (RAGE), alone and in combination with valsartan, an angiotensin receptor blocker, against glomerular injury parameters in streptozotocin-induced diabetic rats. FPS-ZM1 at 1 mg/kg (i. Read More

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http://dx.doi.org/10.1007/s13105-018-0640-2DOI Listing
August 2018
13 Reads

Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36.

J Physiol Biochem 2018 Aug 18;74(3):479-489. Epub 2018 Jun 18.

Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic.

Hypertension, dyslipidemia, and insulin resistance in the spontaneously hypertensive rat (SHR) can be alleviated by rescuing CD36 fatty acid translocase. The present study investigated whether transgenic rescue of CD36 in SHR could affect mitochondrial function and activity of selected metabolic enzymes in the heart. These analyses were conducted on ventricular preparations derived from SHR and from transgenic strain SHR-Cd36 that expresses a functional wild-type CD36. Read More

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http://dx.doi.org/10.1007/s13105-018-0641-1DOI Listing
August 2018
6 Reads

Voluntary exercise opposes insulin resistance of skeletal muscle glucose transport during liquid fructose ingestion in rats.

J Physiol Biochem 2018 Aug 7;74(3):455-466. Epub 2018 Jun 7.

Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.

We have recently reported that male rats given liquid fructose ingestion exhibit features of cardiometabolic abnormalities including non-obese insulin resistance with impaired insulin signaling transduction in skeletal muscle (Rattanavichit Y et al. Am J Physiol Regul Integr Comp Physiol 311: R1200-R1212, 2016). While exercise can attenuate obesity-related risks of cardiometabolic syndrome, the effectiveness and potential mechanism by which exercise modulates non-obese insulin resistance have not been fully studied. Read More

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http://dx.doi.org/10.1007/s13105-018-0639-8DOI Listing
August 2018
8 Reads

PTRF acts as an adipokine contributing to adipocyte dysfunctionality and ectopic lipid deposition.

J Physiol Biochem 2018 Nov 4;74(4):613-622. Epub 2018 Jun 4.

Adipocyte and Fat Biology Laboratory (AdipoFat), Unidad de Investigación Traslacional, Instituto Aragonés de Ciencias de la Salud (IACS), Instituto de Investigación Sanitaria (IIS) Aragón, Hospital Universitario Miguel Servet, Isabel la Católica, 1-3, 50009, Zaragoza, Spain.

Adipose tissue (AT) expands under obesogenic conditions. Yet, when the growth exceeds a certain limit, AT becomes dysfunctional and surplus lipids start depositing ectopically. Polymerase I and transcription release factor (PTRF) has been proposed as a mechanism leading to a dysfunctional AT by decreasing the adipogenic potential of human adipocyte precursors. Read More

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http://dx.doi.org/10.1007/s13105-018-0638-9DOI Listing
November 2018
7 Reads

Physical training improves thermogenesis and insulin pathway, and induces remodeling in white and brown adipose tissues.

J Physiol Biochem 2018 Aug 25;74(3):441-454. Epub 2018 May 25.

Programa de Pós-Graduação em Saúde e Nutrição, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.

Physical training (PT) has been considered as a treatment in metabolic syndrome (MS), since it induces thermogenic activity in brown (BAT) and white (WAT) adipose tissues. We evaluated the therapeutic effect of PT on activity of WAT and BAT in rats with MS induced by high-fat diet (30% lard) for 13 weeks and submitted, for the last 6 weeks, to swimming or kept sedentary (SED) rats. MS-SED rats compared to control diet (CT-SED) rats showed low physical fitness and high levels of glucose, insulin, homeostasis evaluation of insulin resistance (HOMA-IR), homeostasis evaluation of the functional capacity of β-cells (HOMA-β), and blood pressure. Read More

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http://dx.doi.org/10.1007/s13105-018-0637-xDOI Listing
August 2018
5 Reads

Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids.

J Physiol Biochem 2018 Nov 22;74(4):579-589. Epub 2018 May 22.

Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research, University of Navarra, c / Irunlarrea 1, 31008, Pamplona, Navarra, Spain.

The main aim of this investigation was to study the regulatory roles of let-7b and miR-155-3p on the expression of inflammation-associated genes in monocytes, macrophages, and lipopolysaccharide (LPS)-activated macrophages (AcM). A second goal was to analyze the potential modulatory roles of different fatty acids, including oleic, palmitic, eicosapentaenoic (EPA), and docosahexaenoic (DHA), on the expression of these miRNAs in the three cell types. This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24 h. Read More

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http://dx.doi.org/10.1007/s13105-018-0629-xDOI Listing
November 2018
2 Reads

Downregulation of lncRNA MALAT1 contributes to renal functional improvement after duodenal-jejunal bypass in a diabetic rat model.

J Physiol Biochem 2018 Aug 21;74(3):431-439. Epub 2018 May 21.

Department of General Surgery, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, 250012, People's Republic of China.

Ameliorated renal function has been reported after bariatric surgery, but the mechanisms underlying this phenomenon are not well-studied. To investigate whether the long non-coding RNA (lncRNA) MALAT1 mediates the amelioration of diabetic nephropathy after duodenal-jejunal bypass (DJB) surgery, rats were assigned randomly into four groups: diabetic (DM) group, DM with DJB surgery group, DM with sham surgery group, and healthy control group. Food intake, body weight, oral glucose tolerance test (OGTT), urine albumin excretion rate (UAER), and glomerular filtration rate (GFR) were measured and histological examination of renal sections was performed. Read More

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http://dx.doi.org/10.1007/s13105-018-0636-yDOI Listing
August 2018
6 Reads

Metabolomic analysis and biochemical changes in the urine and serum of streptozotocin-induced normal- and obese-diabetic rats.

J Physiol Biochem 2018 Aug 15;74(3):403-416. Epub 2018 May 15.

Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Diabetes mellitus (DM) is a chronic disease that can affect metabolism of glucose and other metabolites. In this study, the normal- and obese-diabetic rats were compared to understand the diabetes disorders of type 1 and 2 diabetes mellitus. This was done by evaluating their urine metabolites using proton nuclear magnetic resonance (H NMR)-based metabolomics and comparing with controls at different time points, considering the induction periods of obesity and diabetes. Read More

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http://dx.doi.org/10.1007/s13105-018-0631-3DOI Listing
August 2018
6 Reads

NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia.

J Physiol Biochem 2018 Aug 11;74(3):417-429. Epub 2018 May 11.

Division of Neuroscience, Biomedical Center BioMed, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4, 036 01, Martin, Slovakia.

Cardiac arrest is one of the leading causes of death among adults in older age. Understanding mechanisms how organism responds to ischemia at global level is essential for the prevention and ischemic patient's treatment. In this study, we used a global cerebral ischemia induced by four-vessel occlusion as an established animal model for ischemic stroke to investigate metabolic changes after 24 h reperfusion, when transitions occur due to the onset of delayed neuronal death. Read More

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http://dx.doi.org/10.1007/s13105-018-0632-2DOI Listing
August 2018
7 Reads

Oral administration of lipid oil-in-water emulsions performed with synthetic or protein-type emulsifiers differentially affects post-prandial triacylglycerolemia in rats.

J Physiol Biochem 2018 Nov 3;74(4):603-612. Epub 2018 May 3.

Institut de Chimie des Membranes et des Nano-objects (CBMN), UMR 5248, CNRS, Université de Bordeaux, Bordeaux INP, Bât B14, 1 Allée Geoffroy Saint-Hilaire, 33600, Pessac, France.

In this study, we compared the impact of administration of size-calibrated lipid emulsions prepared with either synthetic or natural emulsifiers on the post-absorptive plasma triacylglycerol responses in rats. We did this using four types of size-calibrated (10 μm diameter) and metastable (3 days) emulsions with 20% of an oleic acid-rich sunflower oil and 1% of either synthetic emulsifiers (Tween 80 or sodium 2-stearoyl-lactylate) or two proteins (β-lactoglobulin or sodium caseinate). An oral fat tolerance test was performed in fasted rats by oral administration of each of these formulations in continuous or emulsified forms. Read More

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http://dx.doi.org/10.1007/s13105-018-0634-0DOI Listing
November 2018
4 Reads

Effects of reactive oxygen species and interplay of antioxidants during physical exercise in skeletal muscles.

J Physiol Biochem 2018 Aug 1;74(3):359-367. Epub 2018 May 1.

Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105 Bairro Universitário, Criciúma, Santa Catarina, 88806-000, Brazil.

A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxidants and reduce oxidative damage. Yet, strenuous exercise perturbs the antioxidant system by increasing the reactive oxygen species (ROS) content. Read More

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http://dx.doi.org/10.1007/s13105-018-0633-1DOI Listing
August 2018
2 Reads

The relationship between adiposopathy and glucose-insulin homeostasis is not affected by moderate-intensity aerobic training in healthy women with obesity.

J Physiol Biochem 2018 Nov 26;74(4):591-601. Epub 2018 Apr 26.

Department of Kinesiology, Faculty of Medicine, Laval University, Québec, QC, G1V 0A6, Canada.

The contribution of adiposopathy to glucose-insulin homeostasis remains unclear. This longitudinal study examined the potential relationship between the adiponectin/leptin ratio (A/L, a marker of adiposopathy) and insulin resistance (IR: homeostasis model assessment (HOMA)), insulin sensitivity (IS: Matsuda), and insulin response to an oral glucose tolerance test before and after a 16-week walking program, in 29 physically inactive pre- and postmenopausal women with obesity (BMI, 29-35 kg/m; age, 47-54 years). Anthropometry, body composition, VOmax, and fasting lipid-lipoprotein and inflammatory profiles were assessed. Read More

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http://dx.doi.org/10.1007/s13105-018-0630-4DOI Listing
November 2018
2 Reads

CypD-mPTP axis regulates mitochondrial functions contributing to osteogenic dysfunction of MC3T3-E1 cells in inflammation.

J Physiol Biochem 2018 Aug 20;74(3):395-402. Epub 2018 Apr 20.

State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Haiyang Yu 14 S Renmin Rd. 3rd Sec., Chengdu, 610041, Sichuan, People's Republic of China.

Bone is a dynamic organ, the bone-forming osteoblasts and bone-resorbing osteoclasts form the physiological basis of bone remodeling process. During pathological process of numerous inflammatory diseases, these two aspects are uncoupled and the balance is usually tipped in favor of bone destruction. Evidence suggests that the inflammatory destruction of bone is mainly attributed to oxidative stress and is closely related to mitochondrial dysfunction. Read More

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http://dx.doi.org/10.1007/s13105-018-0627-zDOI Listing
August 2018
10 Reads
1.970 Impact Factor

Evidence for the link between defective autophagy and inflammation in peripheral blood mononuclear cells of type 2 diabetic patients.

J Physiol Biochem 2018 Aug 13;74(3):369-379. Epub 2018 Apr 13.

Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Autophagy was shown to modulate inflammation in immune cells. This study was designed to evaluate the association between autophagy and inflammation in peripheral blood mononuclear cells (PBMCs) of type 2 diabetic (T2D) and non-diabetic (ND) subjects. The autophagy markers were measured by real-time PCR and western blot. Read More

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http://dx.doi.org/10.1007/s13105-018-0624-2DOI Listing
August 2018
4 Reads

miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.

J Physiol Biochem 2018 Aug 13;74(3):381-393. Epub 2018 Apr 13.

Hunan Institute of Animal & Veterinary Science, Changsha, 410131, People's Republic of China.

Differentiation of adipocytes and their aggregation to adipose tissue are critical for mammalian growth and development. MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that play important roles in adipogenesis and lipid metabolism. miR-128-3p may contribute to adipose tissue development according to the previous studies. Read More

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http://dx.doi.org/10.1007/s13105-018-0625-1DOI Listing
August 2018
6 Reads

Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients.

J Physiol Biochem 2018 Nov 10;74(4):569-577. Epub 2018 Apr 10.

UNH, Unité de Nutrition Humaine, PFEM, MetaboHUB-Clermont, Université Clermont Auvergne, INRA, CRNH Auvergne, F-63000 Clermont-Ferrand, 63122, Theix, France.

High-sugar intake and senescence share common deleterious effects, in particular in liver, but combination of these two factors was little studied. Our aims were to examine the effect of a high-sucrose diet in liver of old rats and also the potential benefices of a polyphenol/micronutrient supplementation. Four groups of 22-month-old male rats fed during 5 months with a diet containing either 13 or 62% sucrose, supplemented or not with rutin, vitamin E, A, D, selenium, and zinc were compared. Read More

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http://dx.doi.org/10.1007/s13105-018-0628-yDOI Listing
November 2018
5 Reads

Modulation of diabetes-related liver injury by the HMGB1/TLR4 inflammatory pathway.

J Physiol Biochem 2018 May 2;74(2):345-358. Epub 2018 Apr 2.

Department of Molecular Biology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar despota Stefana 142, Belgrade, 11060, Republic of Serbia.

Chronic inflammation plays an essential role in the development of diabetic complications. Understanding the molecular mechanisms that support inflammation is a prerequisite for the design of novel anti-inflammatory therapies. These would take into consideration circulating levels of cytokines and damage-associated molecular patterns (DAMPs) that include the high mobility group box 1 (HMGB1) protein which, in part, promotes the inflammatory response through TLR4 signaling. Read More

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http://dx.doi.org/10.1007/s13105-018-0626-0DOI Listing
May 2018
6 Reads

Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.

J Physiol Biochem 2018 May 27;74(2):335-343. Epub 2018 Mar 27.

Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Medical School of Nanjing University, Nanjing, 210008, China.

Hind limb ischemia-reperfusion injury is an important pathology in vascular surgery. Reactive oxygen species are thought to be involved in the pathogenesis of hind limb ischemia-reperfusion injury. SS-31, which belongs to a family of mitochondrion-targeted peptide antioxidants, was shown to reduce mitochondrial reactive oxygen species production. Read More

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http://dx.doi.org/10.1007/s13105-018-0617-1DOI Listing
May 2018
40 Reads
1.970 Impact Factor

Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area.

J Physiol Biochem 2018 May 26;74(2):325-334. Epub 2018 Mar 26.

Departamento de Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.

To assess the possible function of glutamate in the interaction between the dorsomedial hypothalamic nucleus-perifornical area (DMH-PeF) and the A5 pontine region (A5), cardiovascular and respiratory changes were studied in response to electrical stimulation of the DMH-PeF (1 ms pulses, 30-50 μA given at 100 Hz for 5 s) before and after the microinjection of kynurenic acid (non-specific glutamate receptor antagonist; 50 nl, 5 nmol), MK-801 (NMDA receptor antagonist; 50 nl, 50 nmol), CNQX (non-NMDA receptor antagonist; 50 nl, 50 nmol) or MCPG (metabotropic glutamate receptor antagonist; 50 nl, 5 nmol) within the A5 region. DMH-PeF electrical stimulation elicited a pressor (p < 0.001) and tachycardic response (p < 0. Read More

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http://dx.doi.org/10.1007/s13105-018-0623-3DOI Listing
May 2018
2 Reads

Effects of exosomes from LPS-activated macrophages on adipocyte gene expression, differentiation, and insulin-dependent glucose uptake.

J Physiol Biochem 2018 Nov 20;74(4):559-568. Epub 2018 Mar 20.

Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, c /Irunlarrea 1, 31008, Pamplona, Navarra, Spain.

Obesity is usually associated with low-grade inflammation, which determines the appearance of comorbidities like atherosclerosis and insulin resistance. Infiltrated macrophages in adipose tissue are partly responsible of this inflammatory condition. Numerous studies point to the existence of close intercommunication between macrophages and adipocytes and pay particular attention to the proinflammatory cytokines released by both cell types. Read More

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http://dx.doi.org/10.1007/s13105-018-0622-4DOI Listing
November 2018
6 Reads

Protective effect of the total flavonoids from Apocynum venetum L. on carbon tetrachloride-induced hepatotoxicity in vitro and in vivo.

J Physiol Biochem 2018 May 14;74(2):301-312. Epub 2018 Mar 14.

The Comprehensive Liver Cancer Center, Beijing 302 Hospital, Beijing, 100039, China.

Apocynum venetum L., belonging to the family Apocynaceae, is a popular medicinal plant, which is commonly used in the treatment of hypertension, neurasthenia, and hepatitis in China. In the present study, the total flavonoids (TFs) were prepared from the leaves of A. Read More

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http://dx.doi.org/10.1007/s13105-018-0618-0DOI Listing
May 2018
8 Reads

Natural antioxidants in prevention of accelerated ageing: a departure from conventional paradigms required.

Authors:
Carine Smith

J Physiol Biochem 2018 Nov 14;74(4):549-558. Epub 2018 Mar 14.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

The modern lifestyle is characterised by various factors that cause accelerating ageing by the upregulation of oxidative stress and inflammation-two processes that are inextricably linked in an endless circle of self-propagation. Inflammation in particular is commonly accepted as aetiological factor in many chronic disease states, such as obesity, diabetes and depression. In terms of disease prevention or treatment, interventions aimed at changing dietary and/or exercise habits have had limited success in practise, mostly due to poor long-term compliance. Read More

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http://dx.doi.org/10.1007/s13105-018-0621-5DOI Listing
November 2018
2 Reads

CXCL5 regulation of proliferation and migration in human non-small cell lung cancer cells.

J Physiol Biochem 2018 May 10;74(2):313-324. Epub 2018 Mar 10.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai, 200032, China.

Epithelial neutrophil-activating peptide-78 (CXCL5), a member of the subgroup of CXC-type chemokine family, is an inflammatory factor involved in the progression of lung cancer, but the underlying mechanism remains unclear. In this study, we investigated the effects of CXCL5 on proliferation and migration in non-small cell lung cancer (NSCLC) using tissue microarrays from NSCLC patients and H460 cells transfected with a CXCL5-interfered lentivirus vector or stimulated with recombinant CXCL5. We observed that the expression of CXCL5 was significantly higher in lung cancer cell lines, and high CXCL5 was associated with high chemokine (C-X-C motif) receptor 2 expression and was significantly associated with poor differentiation. Read More

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http://dx.doi.org/10.1007/s13105-018-0619-zDOI Listing
May 2018
4 Reads

Sceletium tortuosum may delay chronic disease progression via alkaloid-dependent antioxidant or anti-inflammatory action.

J Physiol Biochem 2018 Nov 9;74(4):539-547. Epub 2018 Mar 9.

Department of Physiological Sciences, Science Faculty, Stellenbosch University, Stellenbosch, South Africa.

The link between obesity-induced systemic inflammation and decreased insulin signalling is well-known. It is also known that peripherally produced inflammatory cytokines can cross the blood-brain barrier, resulting in the release of neurotoxins that can ultimately lead to the demise of central nervous system integrity. A high-mesembrine Sceletium tortuosum extract was recently shown to possess cytoprotective and mild anti-inflammatory properties in monocytes and to target specific p450 enzymes to reduce adrenal glucocorticoid synthesis. Read More

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http://dx.doi.org/10.1007/s13105-018-0620-6DOI Listing
November 2018
2 Reads

The protective effects of metformin in an in vitro model of aging 3T3 fibroblast under the high glucose conditions.

J Physiol Biochem 2018 May 6;74(2):273-281. Epub 2018 Mar 6.

Department of Medical Biology and Genetics, Istanbul Aydin University, Medical Faculty, 34295 Sefakoy-Kucukcekmece, Istanbul, Turkey.

Metformin is the most widely used anti-diabetic drug in the world. It reduces advanced glycation end product (AGEs)-induced ROS generation in high glucose condition. Protein glycation contributes to skin aging as it deteriorates the existing collagen by crosslinking. Read More

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http://dx.doi.org/10.1007/s13105-018-0613-5DOI Listing
May 2018
44 Reads
1.970 Impact Factor

Physical exercise mitigates high-fat diet-induced adiposopathy and related endocrine alterations in an animal model of obesity.

J Physiol Biochem 2018 May 24;74(2):235-246. Epub 2018 Feb 24.

CIAFEL-Research Centre in Physical Activity, Health and Leisure, Faculty of Sport Sciences, University of Porto, Rua Dr. Plácido Costa, 91, 4200-450, Porto, Portugal.

The dysregulation of adipokine secretion owing to adiposopathy can contribute to the pathogenesis of obesity-related disorders. Being that exercise is an advised strategy against obesity-induced adiposopathy, we aimed to analyze the role of physical exercise as a preventive and therapeutic strategy against high-fat diet (HFD)-induced adipokine and ghrelin alterations. Rats were pair-fed the Lieber De Carli standard diet (S, 35 Kcal% fat) or HFD (71 Kcal% fat) over 17 weeks. Read More

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http://dx.doi.org/10.1007/s13105-018-0609-1DOI Listing
May 2018
6 Reads

Hepatic subcellular distribution of squalene changes according to the experimental setting.

J Physiol Biochem 2018 Nov 22;74(4):531-538. Epub 2018 Feb 22.

CIBER de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28029, Madrid, Spain.

Squalene is the main unsaponifiable component of virgin olive oil, the main source of dietary fat in Mediterranean diet, traditionally associated with a less frequency of cardiovascular diseases. In this study, two experimental approaches were used. In the first, New Zealand rabbits fed for 4 weeks with a chow diet enriched in 1% sunflower oil for the control group, and in 1% of sunflower oil and 0. Read More

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http://dx.doi.org/10.1007/s13105-018-0616-2DOI Listing
November 2018
3 Reads