14,794 results match your criteria Journal of Pharmacy and Pharmacology[Journal]


Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats.

J Pharm Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Effect of alpha-linolenic acid (ALA) against ovalbumin (OVA)-induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat.

Methods: Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13094DOI Listing
April 2019
1 Read

Chlorogenic acid inhibits proliferation and induces apoptosis in A498 human kidney cancer cells via inactivating PI3K/Akt/mTOR signalling pathway.

J Pharm Pharmacol 2019 Apr 15. Epub 2019 Apr 15.

Department of Oncology, The First Affiliated Hospital, Jinan University, Guangzhou, China.

Objectives: Kidney cancer is a highly lethal cancer, of which the most common type is renal cell carcinoma (RCC). The targeted drugs used in treating RCC clinically have a lot of side effects. Therefore, it is urgent to find out effective agents with little toxic effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13095DOI Listing
April 2019
1 Read

Pitavastatin attenuates cisplatin-induced renal injury by targeting MAPK and apoptotic pathways.

J Pharm Pharmacol 2019 Apr 7. Epub 2019 Apr 7.

Cardiovascular Research Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.

Objective: Anti-neoplastic drug cisplatin is prescribed widely for treatment of a variety of malignancies. Its use has been restricted lately due to severe renal toxicity. The purpose of current study was to investigate the effect of pitavastatin (a hypolipidaemic drug) in cisplatin-induced acute kidney injury in rats. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.13090
Publisher Site
http://dx.doi.org/10.1111/jphp.13090DOI Listing
April 2019
2 Reads

Raloxifene decreases cell viability and migratory potential in prostate cancer cells (LNCaP) with GPR30/GPER1 involvement.

J Pharm Pharmacol 2019 Mar 28. Epub 2019 Mar 28.

Department of Morphology, Institute of Biosciences, São Paulo State University, UNESP, Botucatu, SP, Brazil.

Objectives: This study evaluated raloxifene (ral) effects on LNCaP prostate tumour cells modulating the activity of GPER1/GPR30 receptors.

Methods: LNCaP cells were submitted for 40/120 min and 12 h to the following treatments: C: RPMI + DMSO; R: RPMI + Ral; G: RPMI + Ral + G15 (GPER1 antagonist). Trypan blue staining measured cell viability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13089DOI Listing

Curcumin solid dispersion-loaded in situ hydrogels for local treatment of injured vaginal bacterial infection and improvement of vaginal wound healing.

J Pharm Pharmacol 2019 Mar 18. Epub 2019 Mar 18.

Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng, China.

Objectives: Injured vaginal infection is detrimental to women. A curcumin hydrogel was studied for local treatment of injured vaginal infection.

Methods: Curcumin solid dispersions (CSDs) were prepared from polyvinyl pyrrolidone and characterized by differential scanning calorimetry and an X-ray diffraction method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13088DOI Listing

A population pharmacokinetic model of vancomycin for dose individualization based on serum cystatin C as a marker of renal function.

J Pharm Pharmacol 2019 Mar 14. Epub 2019 Mar 14.

Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi, China.

Objectives: This study aimed to establish a vancomycin population pharmacokinetics (PPK) model based on serum cystatin C and to optimize dosing for achieving targeted steady-state trough concentrations (C ) of 10-15 and 15-20 mg/l.

Methods: Patients aged ≥18 years were prospectively enrolled. A vancomycin PPK model was built with glomerular filtration rate (GFR) as a renal covariate estimated by cystatin C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13071DOI Listing
March 2019
2 Reads

Tanshinone IIA protects against lipopolysaccharide-induced lung injury through targeting Sirt1.

J Pharm Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Institute of Translational Medicine, Nanchang University, Nanchang, China.

Objectives: This study was designed to investigate the effects and the mechanism of Tanshinone IIA (TIIA) on endotoxic shock-induced lung injury in a mouse model.

Methods: Mice were administered intraperitoneally with TIIA (10 mg/kg) 0.5 h before lipopolysaccharide (LPS) challenge and then received additional injections every 24 h during the 3-day experimental period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13087DOI Listing
March 2019
1 Read

Effect of a new cyclic derivative of GABA, RGPU-207, on the functions of cardiac and cerebral mitochondria of stressed animals.

J Pharm Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

Department for Pharmacology and Biopharmacy, Volgograd State Medical University, Volgograd, Russian Federation.

Objectives: The objective of this study was to investigate the effects of a new derivative of GABA, RGPU-207 compound, on the mitochondrial functions of stressed animals.

Methods: RGPU-207 and the comparator drugs (phenibut and piracetam) were administered intraperitoneally to unstressed and stressed male rats at a dose of 9.4, 25 and 400 mg/kg, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13086DOI Listing

Mangiferin attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting TLR4/p65 and TGF-β1/Smad2/3 pathway.

J Pharm Pharmacol 2019 Mar 7. Epub 2019 Mar 7.

Yanan University Affiliated Hospital, Yanan, Shanxi, China.

Objectives: Investigating the antipulmonary fibrosis effect of mangiferin from Mangifera indica and the possible molecular mechanism.

Methods: In vivo, bleomycin (BLM)-induced pulmonary fibrosis experimental model was used for evaluating antipulmonary fibrosis effect of mangiferin. Histopathologic examination and collagen deposition were investigated by HE and Masson staining as well as detecting the content of hydroxyproline. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13077DOI Listing

Molecular mechanism of tuberoinfundibular peptide of 39 on glucocorticoid receptor mediated glutamate/GABA imbalance and cerebral abnormalities against cognitive deficit model.

J Pharm Pharmacol 2019 Mar 5. Epub 2019 Mar 5.

Department of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

Objectives: This study is designed to evaluate the role of tuberoinfundibular peptide of 39 (TIP39) in connection with glucocorticoid receptor-mediated glutamate/GABA abnormalities in chronic unpredictable mild stress (CUMS) model.

Methods: Male Sprague-Dawley rats were treated with TIP39 (1 and 10 nmol, i.c. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13085DOI Listing
March 2019
1 Read

Synthesis, cytotoxicity and liver targeting of 3-O-β-D-Galactosylated Resveratrol.

J Pharm Pharmacol 2019 Mar 4. Epub 2019 Mar 4.

School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, China.

Objectives: Resveratrol (Res), a naturally occurring polyphenol, has shown pharmacological activities in treatment of liver diseases. However, the application of Res was limited by its poor bioavailability and liver targeting. Herein, 3-O-β-D-Galactosylated Resveratrol (Gal-Res) was synthesized by structural modification of Res to enhance bioavailability and liver targeting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13084DOI Listing

The PEARRL reviews - innovative drug development strategies tailored to facilitate earlier access to new oral medicines.

J Pharm Pharmacol 2019 Apr;71(4):439-440

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13083DOI Listing

Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1.

J Pharm Pharmacol 2019 Feb 27. Epub 2019 Feb 27.

Hyperlipidemia Research Center, Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objectives: TGF-β through hyperelongation of glycosaminoglycan (GAG) chains leads to binding of low-density lipoproteins to the proteoglycans. The vasoactive peptide, endothelin-1 (ET-1), plays a key role in the development of atherosclerosis. This study addressed the question whether ET-1 by activating the Rho kinase and cytoskeletal rearrangement can transactivate the TGF-β receptor leading to phosphorylation of the transcription factor Smad2 and increased expression of the GAG chain synthesizing enzyme such as chondroitin synthase-1 (CHSY-1) in bovine aortic endothelial cells (BAECs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13081DOI Listing
February 2019
1 Read

Neuroprotective effect of pharmacological postconditioning on cerebral ischaemia-reperfusion-induced injury in mice.

J Pharm Pharmacol 2019 Feb 27. Epub 2019 Feb 27.

Department of Pharmacology, Chitkara college of Pharmacy, Chitkara University, Patiala, India.

Objectives: To investigate the mechanism of neuroprotection rendered via pharmacological postconditioning in cerebral ischaemia-reperfusion-induced injury in mice.

Methods: Pharmacological postconditioning is strategy which either involves hindering deleterious pathway or inducing modest stress level which triggers intracellular defence pathway to sustain more vigorous insult leading to conditioning. Hence, in current research we explored the potentiality of CGS21680 (0. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.13073
Publisher Site
http://dx.doi.org/10.1111/jphp.13073DOI Listing
February 2019
2 Reads

Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies.

J Pharm Pharmacol 2019 Feb 25. Epub 2019 Feb 25.

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

Objectives: The cationic biopolymer chitosan (CH) has emerged as a promising candidate adjuvant due to its safety profile and immunostimulatory properties. The presence of endotoxin contamination in biomaterials is generally underappreciated and can generate misleading results. It is important to establish a convenient methodology to obtain large amounts of high quality chitosan nanoparticles for biomedical applications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13082DOI Listing
February 2019

Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl.

J Pharm Pharmacol 2019 Feb 21. Epub 2019 Feb 21.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston, MA, USA.

Objectives: Fentanyl is a potent analgesic that accounts for an increasing number of overdose deaths in the United States. This study tested whether altered pharmacokinetics plays a pivotal role in the increased fentanyl dose requirements in patients receiving the enzyme-inducing anticonvulsant, carbamazepine.

Methods: Neurosurgical patients receiving carbamazepine for >6 weeks (N = 11) or no carbamazepine (N = 6, controls) received a single bolus dose of fentanyl (200 μg) intravenously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13079DOI Listing
February 2019

Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL review.

J Pharm Pharmacol 2019 Apr 22;71(4):699-723. Epub 2019 Feb 22.

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany.

Objectives: The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug-specific PK/PD models and highlighting their value added in drug development and regulatory decision-making.

Key Findings: Many PK/PD models, with varying degrees of complexity and physiological understanding have been developed to evaluate the safety and efficacy of drug products. In special populations (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13070DOI Listing
April 2019
1 Read

Abyssinone V, a prenylated flavonoid isolated from the stem bark of Erythrina melanacantha increases oxidative stress and decreases stress resistance in Caenorhabditis elegans.

J Pharm Pharmacol 2019 Feb 21. Epub 2019 Feb 21.

Institute of Agricultural and Nutritional Sciences, Biofunctionality of Secondary Plant Compounds, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

Objectives: Recent studies showed that distinct extracts of Erythrina species used in the traditional medicine of sub-Saharan Africa are protective against stress conditions. However, the underlying molecular mechanisms as well as relevant compounds remain unclear.

Methods: We used the model organism Caenorhabditis elegans to investigate compounds isolated from the stem bark of Erythrina melanacantha (abyssinone V (1), abyssinon-4'O-methylether (2), sigmoidin B-4'O-methylether (3), glabranin (4), 8-prenylnaringenin (5), citflavanone (6), exiguaflavanone (7) and homoeriodictyol (8)). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13074DOI Listing
February 2019
1 Read

High-throughput screening of excipients with a biological effect: a kinetic study on the effects of surfactants on efflux-mediated transport.

J Pharm Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

Objective: In this study, we develop and apply a high-throughput screening protocol to investigate the activity of non-ionic surfactants, with a broad range of hydrophilic-lipophilic balance values, against ABCB1-mediated efflux transport and ABCC2-mediated efflux transport.

Methods: Caco-2 cells were grown for 7 days in 96-well plates, then washed and incubated with the test materials for 2 h in the presence of 2.5 μm of either rhodamine 123 (R-123) or 5(6)-Carboxy-2',7' dichlorofluorescein diacetate as probes of ABCB1 and ABCC2, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13072DOI Listing
February 2019

The preparation and investigation of spinosin-phospholipid complex self-microemulsifying drug delivery system based on the absorption characteristics of spinosin.

J Pharm Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.

Objectives: The aim of this research was to investigate the intestinal absorption characteristics and mechanisms of spinosin (SPI), and a new dosage form was prepared to increase the intestinal absorption of SPI.

Methods: In this study, the intestinal absorption characteristics and mechanisms of SPI were first investigated using in situ absorption model and Caco-2 monolayer model. Subsequently, the phospholipid complex (PLC) loaded with SPI was prepared followed by a self-microemulsifying drug delivery system (SMEDDS) technique for developing a more efficient formulation. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.13076
Publisher Site
http://dx.doi.org/10.1111/jphp.13076DOI Listing
February 2019
5 Reads

Intra-articular mucilages: behavioural and histological evaluations for a new model of articular pain.

J Pharm Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

NEUROFARBA - Pharmacology and Toxicology Section, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

Objectives: The creation of a new valid preclinical model of articular pain by the intra-articular (i.a.) injection of mucilages for the screening of new treatments against arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13078DOI Listing
February 2019
2 Reads

Polymorphic characterization and implications on biopharmaceutics properties of potential anti-inflammatory drug candidate eremantholide C from Lychnophora trichocarpha (Brazilian Arnica).

J Pharm Pharmacol 2019 Feb 17. Epub 2019 Feb 17.

Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.

Objectives: To perform the polymorphic and physicochemical characterization of the potential anti-inflammatory drug, eremantholide C (EREC), as well as to evaluate the influence of these characteristics on its biopharmaceutics classification.

Methods: Eremantholide C was obtained from chloroformic extract of Lychnophora trichocarpha and crystallized in two distinct solvents: chloroform (EREC 1) and ethyl acetate (EREC 2). To evaluate the polymorphism, EREC samples were submitted to melting point, purity, infrared spectroscopy, differential scanning calorimetry (DSC), X-ray powder diffraction, optical microscopy and scanning electron microscopy analysis. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.13080
Publisher Site
http://dx.doi.org/10.1111/jphp.13080DOI Listing
February 2019
4 Reads

Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy.

J Pharm Pharmacol 2019 May 14;71(5):725-732. Epub 2019 Feb 14.

Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.

Objectives: Curcuma caesia has shown positive results in treating number of diseases, but till date no work was reported on its activity in diabetic neuropathy. So, the present review aims at exploring several hypothesis which can be proposed to explain further its utility in diabetic neuropathy by its antioxidant property, anti-inflammatory, CNS depressant effect, antibacterial and antifungal property. For finding the accurate and exact detail, a thorough review of all the available research and review article was done. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13075DOI Listing
May 2019
3 Reads

LncRNA TapSAKI promotes inflammation injury in HK-2 cells and urine derived sepsis-induced kidney injury.

J Pharm Pharmacol 2019 May 21;71(5):839-848. Epub 2019 Jan 21.

Department of Organ Transplantation, The Affiliated Hospital, Guizhou Medical University, Guiyang, Guizhou, China.

Objective: To explore the possible mechanism of lncRNA TapSAKI in urine derived sepsis-induced kidney injury.

Materials And Methods: In vivo urine-derived sepsis (US) rat model and in vitro LPS-induced HK-2 cells were established, and TapSAKI, miR-22, PTEN, TLR4 and p-p65 expressions were detected by qRT-PCR and western blot. RNA precipitation and RNA pull-down were performed to confirm the interaction between TapSAKI and miR-22. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13049DOI Listing
May 2019
1 Read

Baicalin reduces ciclosporin bioavailability by inducing intestinal p-glycoprotein in rats.

J Pharm Pharmacol 2019 May 21;71(5):788-796. Epub 2019 Jan 21.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objectives: To investigate the effects of multiple doses of baicalin (BG) on the pharmacokinetics of ciclosporin (CsA) in rats and the potential mechanisms.

Methods: Pharmacokinetic parameters of CsA were determined in male rats after administration of CsA (3 mg/kg, i.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13067DOI Listing
May 2019
11 Reads
2.161 Impact Factor

Minimally modified low-density lipoprotein upregulates the ET and α receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway.

J Pharm Pharmacol 2019 Jan 20. Epub 2019 Jan 20.

Institute of Pharmacy and Pharmacology, The First People's Hospital of Chenzhou, University of South China, Chenzhou, China.

Objectives: The current study aimed to explore whether minimally modified low-density lipoprotein (mmLDL) via tail vein injection upregulates the ET and α receptors in mouse mesenteric arteries by activating the PI3K/Akt pathway.

Methods: The contraction curves of the mesenteric arteries caused by sarafotoxin 6c (S6c, ET receptor agonist) and phenylephrine (PE, α receptor agonist) were measured by a myograph system. Serum oxLDL was detected using enzyme-linked immunosorbent assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13069DOI Listing
January 2019
4 Reads
2.161 Impact Factor

Imidazole alkaloids inhibit the pro-inflammatory mechanisms of human neutrophil and exhibit anti-inflammatory properties in vivo.

J Pharm Pharmacol 2019 May 16;71(5):849-859. Epub 2019 Jan 16.

Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.

Objectives: Epiisopiloturine (EPI) and epiisopilosine (EPIIS) are side products in the pharmaceutical industry. The present study aimed to investigate the anti-inflammatory potential of the alkaloids EPI and EPIIS in human neutrophils and mechanical hyperalgesia in mice.

Methods: Neutrophils (5 × 10  cells/ml) incubated with EPI and EPIIS and stimulated by the addition of N-formyl-methionyl-leucyl-phenylalanine or phorbol 12-myristate-13-acetate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13068DOI Listing
May 2019
2 Reads

Soy isoflavone-loaded alginate microspheres in thermosensitive gel base: attempts to improve wound-healing efficacy.

J Pharm Pharmacol 2019 May 14;71(5):774-787. Epub 2019 Jan 14.

Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.

Objectives: This study aims to develop thermosensitive gel containing soy isoflavone (antioxidant and anti-inflammatory natural agent) alginate microspheres for enhancement of wound-healing performance.

Methods: Soy isoflavone microspheres were prepared by ionic cross-linking method and optimized using the Box-Behnken optimization design. Formulations were characterized in terms of particle size, encapsulation efficiency and equilibrium swelling degree. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13066DOI Listing
May 2019
4 Reads
2.161 Impact Factor

Standard concentration infusions of inotropic and vasoactive drugs in paediatric intensive care: a strategy for patient safety.

J Pharm Pharmacol 2019 May 2;71(5):826-838. Epub 2019 Jan 2.

Department of Cardiac Intensive Care, Little Prince Hospital, Curitiba, Brazil.

Objectives: To evaluate the advantages and disadvantages of using different standard concentration infusions for high-alert inotropic and vasoactive drugs in paediatric intensive care units (ICUs).

Methods: Retrospective data analysis was performed on drug prescriptions for patients in paediatric ICUs. A matrix was developed based on optimal concentration recommendations for each drug, taking into consideration solution stability and patient safety. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.13065
Publisher Site
http://dx.doi.org/10.1111/jphp.13065DOI Listing
May 2019
19 Reads

Targeting EphA2 with miR-124 mediates Erlotinib resistance in K-RAS mutated pancreatic cancer.

J Pharm Pharmacol 2019 Feb 2;71(2):196-205. Epub 2019 Jan 2.

People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

Objectives: Chemotheraputic drug resistance is a critical factor associated with the poor survival in advanced/metastatic pancreatic cancer (PC) patients.

Methods: Human pancreatic cell lines Capan-1 and BXPC-3 were cultured with different concentrations of erlotinib (0, 10, 50, and 100 μm) for 48 h. The relative cell viability and apoptosis was detected using MTT assays and flow cytometry apoptosis analysis, respectively. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.12941
Publisher Site
http://dx.doi.org/10.1111/jphp.12941DOI Listing
February 2019
16 Reads

The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat.

J Pharm Pharmacol 2019 May 27;71(5):816-825. Epub 2018 Dec 27.

Department of Biology, Laboratory of Neurobiology, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile.

Objectives: To study the antinociceptive effect of single and repeated doses of resveratrol in a bone cancer pain model, and whether this effect is prevented by the Silent Information Regulator 1 (SIRT1) inhibitor selisistat.

Methods: The femoral intercondylar bone of BALB/c mice was injected with 1 000 000 BJ3Z cancer cells. Bone resorption and tumour mass growth (measured by in vivo X-ray and fluorescence imaging), as well as mechanical nociceptive thresholds (von Frey device) and dynamic functionality (rotarod machine), were evaluated during the following 4 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13064DOI Listing
May 2019
1 Read

Neuroprotective effect of mogrol against Aβ -induced memory impairment neuroinflammation and apoptosis in mice.

J Pharm Pharmacol 2019 May 26;71(5):869-877. Epub 2018 Dec 26.

State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.

Objectives: Cognitive impairment is the main character of Alzheimer's disease (AD). This study mainly focused on whether mogrol, a tetracyclic triterpenoids compound of Siraitia grosvenorii Swingle, can ameliorate the memory impairment induced by Aβ .

Methods: Memory impairment mice model was made by stereotactic intra-hippocampal microinjection of Aβ (410 pm/mouse). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13056DOI Listing
May 2019
1 Read

Preparation, chemical characterization and determination of crocetin's pharmacokinetics after oral and intravenous administration of saffron (Crocus sativus L.) aqueous extract to C57/BL6J mice.

J Pharm Pharmacol 2019 May 21;71(5):753-764. Epub 2018 Dec 21.

Laboratory of Biopharmaceutics and Pharmacokinetics, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Objectives: To prepare a lyophilized saffron aqueous extract (SFE) and determine its chemical profile and serum and tissue pharmacokinetics after intravenous and oral administration to C57/Bl6J mice.

Methods: Lyophilized SFE was prepared, characterized using semi-preparative HPLC and NMR analysis, and stability studies at room temperature, and was quantified for crocin content with an HPLC-PDA method. After intravenous and oral administration of SFE (60 mg/kg, reconstituted with water for injection) to C57/Bl6J mice, crocetin (derived from in vivo crocin hydrolysis) serum and tissue levels (unconjugated and total) were measured with an HPLC-PDA method and subjected to compartmental and non-compartmental PK analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13055DOI Listing
May 2019
11 Reads

Enhancing the oral bioavailability of baicalein via Solutol HS15 and Poloxamer 188 mixed micelles system.

J Pharm Pharmacol 2019 May 14;71(5):765-773. Epub 2018 Dec 14.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Objectives: To increase the solubility of baicalein (BAI) by preparing BAI-micelles (BAI-M) with Solutol HS15 (HS15) and Poloxamer 188 (F68), thereby improving its oral bioavailability.

Methods: Baicalein micelles were prepared with HS15 and F68 by thin-film dispersion method and optimized by central composite design (CCD) approach. Physicochemical, in vitro release, Caco-2 cell transport and pharmacokinetic studies of BAI-M were performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13058DOI Listing
May 2019
2 Reads

Phospholipase Cγ2 signalling contributes to the haemostatic effect of Notoginsenoside Ft1.

J Pharm Pharmacol 2019 May 14;71(5):878-886. Epub 2018 Dec 14.

College of Veterinary Medicine, Northwest A&F University, Yangling, China.

Objectives: The drawback of bleeding caused by chronic antiplatelet therapy is persecuting patients with thrombotic diseases severely. Based on the dual-directional regulatory effect of Panax notoginseng on platelet, the present study focused on the effect of Notoginsenoside Ft1, a saponin with effect in promoting platelet aggregation.

Key Findings: According to the present study, Notoginsenoside Ft1 cannot stimulate platelet aggregation independently. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13057DOI Listing
May 2019
1 Read

Salvianolic acid B inhibits the development of diabetic peripheral neuropathy by suppressing autophagy and apoptosis.

J Pharm Pharmacol 2019 Mar 7;71(3):417-428. Epub 2018 Dec 7.

Department of Traditional Chinese Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Objectives: The aim of this study was to evaluate the neuroprotective effects of SalB on high glucose (HG)-induced excessive autophagy and apoptosis in vitro.

Methods: The proliferation and apoptosis of RSC96 cells were determined using the MTT assay and flow cytometry, respectively. Western blot analysis was performed to examine the expression of autophagy and apoptosis-related proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13044DOI Listing
March 2019
1 Read

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review.

J Pharm Pharmacol 2019 Feb 7;71(2):141-155. Epub 2018 Dec 7.

Programa de Pós-graduação em Ciências Aplicadas à Saúde, Universidade Federal de Sergipe, Lagarto, Sergipe, Brazil.

Objectives: The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.13054
Publisher Site
http://dx.doi.org/10.1111/jphp.13054DOI Listing
February 2019
11 Reads

Suppression of TLR4 by miR-448 is involved in Diabetic development via regulating Macrophage polarization.

J Pharm Pharmacol 2019 May 7;71(5):806-815. Epub 2018 Dec 7.

Department of Endocrinology, Changzhou Wujin People's Hospital, Changzhou, China.

Objectives: Lipopolysaccharide (LPS) contributed to the development and progression of type 2 diabetes mellitus (T2D), while TLR4 is reported to mediate the LPS-induced inflammation in macrophages. However, the potential molecular mechanisms for TLR4-mediated macrophages activation in T2D have not yet to be fully clarified.

Methods: Type 2 diabetes models in C57BL/6J mice were generated by a combination administration of streptozotocin (STZ) and a high-fat diet (HFD). Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.13048
Publisher Site
http://dx.doi.org/10.1111/jphp.13048DOI Listing
May 2019
4 Reads

Study of nuclear factor-2 erythroid related factor-2 activator, berberine, in paclitaxel induced peripheral neuropathy pain model in rats.

J Pharm Pharmacol 2019 May 10;71(5):797-805. Epub 2018 Dec 10.

Department of Pharmacology, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Objectives: The role of nuclear factor-2 erythroid related factor-2 (Nrf2) activator, berberine (BBR), has been established in rat model of streptozotocin induced diabetic neuropathy. Around 30-40% of cancer patients, on paclitaxel (PTX) chemotherapy develop peripheral neuropathy. The present study was contemplated with the aim of establishing the neuropathy preventive role of BBR, in paclitaxel induced peripheral neuropathy model in rats. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.13047
Publisher Site
http://dx.doi.org/10.1111/jphp.13047DOI Listing
May 2019
5 Reads

St John's wort (Hypericum perforatum L.): botanical, chemical, pharmacological and clinical advances.

J Pharm Pharmacol 2019 Jan;71(1):1-3

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13053DOI Listing
January 2019
1 Read

Pharmacokinetic and pharmacodynamic studies of pregabalin suppositories based on pharmacological research.

J Pharm Pharmacol 2019 May 4;71(5):746-752. Epub 2018 Dec 4.

Pharmaceutical Common Achievement Tests Organization, Tokyo, Japan.

Objectives: As commercially available pregabalin preparations are limited to oral administration, it is impossible to use it as an adjuvant analgesic for neuropathic cancer-related pain in terminally ill cancer patients with oral feeding difficulties. The objective of this study was to develop a pregabalin suppository to be available at hospitals.

Methods: Pregabalin suppositories were prepared using bases comprising six different compositions of Witepsol H-15, Witepsol S-55, and Witepsol E-75. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13051DOI Listing
May 2019
1 Read

Curcumin and a hemi-analogue with improved blood-brain barrier permeability protect against amyloid-beta toxicity in Caenorhabditis elegans via SKN-1/Nrf activation.

J Pharm Pharmacol 2019 May 4;71(5):860-868. Epub 2018 Dec 4.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Objectives: This study aims to investigate the blood-brain barrier (BBB) permeability of curcumin analogues with shortened linkers and their ability to protect against amyloid-beta toxicity in a whole organism model.

Method: Four curcumin analogues were synthesized. These analogues and curcumin were evaluated for their BBB permeability in the parallel artificial membrane permeability assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13052DOI Listing
May 2019
1 Read
2.161 Impact Factor

Quercetin and 3-O-methylquercetin in vitro skin layers permeation/retention from hydrogels: why only a methoxy group difference determines different behaviors?

J Pharm Pharmacol 2019 May 3;71(5):733-745. Epub 2018 Dec 3.

Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objectives: The present study was designed to verify if quercetin (QCT), a flavonoid with antioxidant and antiviral activity, and 3-O-methylquercetin (3OMQ), a quercetin C3-methoxylated derivative, present differences in their behavior against complexation with β-cyclodextrin (β-CD) and the corresponding permeation/retention trhough porcine ear skin, when incorporated into hydroxypropyl methylcellulose (HPMC) or chitosan (CS) hydrogels.

Methods: The influence of β-CD on the skin permeation/retention of QCT and 3OMQ from hydrogels is comparatively evaluated for both flavonoids using porcine ear skin in Franz cells model. The properties of the two flavonoids using the semi-empirical method Recife Model was studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13050DOI Listing
May 2019
5 Reads

Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology.

J Pharm Pharmacol 2019 Mar 28;71(3):293-305. Epub 2018 Nov 28.

Department of Pharmaceutics and Drug Delivery, The University of Mississippi School of Pharmacy, University, MS, USA.

Objectives: To investigate the effects of formulation composition on the physico-chemical and drug release properties of mucoadhesive buccal films prepared by melt extrusion technology, using a response surface methodology.

Methods: Salbutamol sulphate, an antiasthmatic drug was used for this study. Klucel hydroxypropylcellulose (HPC) EF (film-forming polymer), Benecel hydroxypropylmethylcellulose (HPMC) K-15M (drug release retardant) and polyethylene glycol (PEG) 4500 (plasticiser) were the three independent factors utilised for the study. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.13046
Publisher Site
http://dx.doi.org/10.1111/jphp.13046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402047PMC
March 2019
7 Reads

Effect of an anxiolytic botanical containing Souroubea sympetala and Platanus occidentalis on in-vitro diazepam human cytochrome P450-mediated metabolism.

J Pharm Pharmacol 2019 Mar 22;71(3):429-437. Epub 2018 Nov 22.

Department of Biology, University of Ottawa, Ottawa, ON, Canada.

Objectives: A novel anxiolytic natural health product (NHP) containing Souroubea sympetala and Platanus occidentalis is available for the companion animal market and is currently being developed for clinical evaluation. Addressing the risk of potential NHP-drug interactions, this study investigated S. sympetala and P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13045DOI Listing
March 2019
14 Reads
2.161 Impact Factor

Anomalous interaction of tri-acyl ester derivatives of uridine nucleoside with a l-α-dimyristoylphosphatidylcholine biomembrane model: a differential scanning calorimetry study.

J Pharm Pharmacol 2019 Mar 20;71(3):329-337. Epub 2018 Nov 20.

Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Catania, Italia.

Objectives: Uridine was conjugated with fatty acids to improve the drug lipophilicity and the interaction with phospholipid bilayers.

Methods: The esterification reaction using carbodiimides compounds as coupling agents and a nucleophilic catalyst allowed us to synthesize tri-acyl ester derivatives of uridine with fatty acids. Analysis of molecular interactions between these tri-acyl ester derivatives and l-α-dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV) - as a mammalian cell membrane model - have been performed by differential scanning calorimetry (DSC). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.13038
Publisher Site
http://dx.doi.org/10.1111/jphp.13038DOI Listing
March 2019
14 Reads

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models.

J Pharm Pharmacol 2019 Mar 19;71(3):379-389. Epub 2018 Nov 19.

Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Ceará, Brazil.

Objectives: To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine-induced schizophrenia model.

Methods: Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jphp.13039DOI Listing
March 2019
19 Reads

Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats.

J Pharm Pharmacol 2019 Mar 20;71(3):400-407. Epub 2018 Nov 20.

Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.

Objectives: Reducing endoplasmic reticulum stress (ERS)-induced cardiomyocyte apoptosis is a key strategy for preventing hypertensive heart disease. In our previous study, Icariside II can improve left ventricular remodelling in spontaneously hypertensive rats (SHRs). This study aims to determine whether Icariside II can exert its effect by inhibiting ERS-induced cardiomyocyte apoptosis via the PERK/ATF-4/CHOP signalling pathway. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.13041
Publisher Site
http://dx.doi.org/10.1111/jphp.13041DOI Listing
March 2019
13 Reads

The protective effects of Δ -tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia.

J Pharm Pharmacol 2019 Mar 14;71(3):408-416. Epub 2018 Nov 14.

Department of Medical Biology, Faculty of Cerrahpasa Medicine, Istanbul University, Istanbul, Turkey.

Objectives: A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Δ -tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The study aims to investigate the effects of THC treatment on inflammation, lipid profiles and oxidative stress in rat liver with hyperinsulinemia. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jphp.13042
Publisher Site
http://dx.doi.org/10.1111/jphp.13042DOI Listing
March 2019
7 Reads