14,760 results match your criteria Journal of Pharmacy and Pharmacology [Journal]


Enhancing the oral bioavailability of baicalein via Solutol HS15 and Poloxamer 188 mixed micelles system.

J Pharm Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Objectives: To increase the solubility of baicalein (BAI) by preparing BAI-micelles (BAI-M) with Solutol HS15 (HS15) and Poloxamer 188 (F68), thereby improving its oral bioavailability.

Methods: Baicalein micelles were prepared with HS15 and F68 by thin-film dispersion method and optimized by central composite design (CCD) approach. Physicochemical, in vitro release, Caco-2 cell transport and pharmacokinetic studies of BAI-M were performed. Read More

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http://dx.doi.org/10.1111/jphp.13058DOI Listing
December 2018

Phospholipase Cγ2 signalling contributes to the haemostatic effect of Notoginsenoside Ft1.

J Pharm Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

College of Veterinary Medicine, Northwest A&F University, Yangling, China.

Objectives: The drawback of bleeding caused by chronic antiplatelet therapy is persecuting patients with thrombotic diseases severely. Based on the dual-directional regulatory effect of Panax notoginseng on platelet, the present study focused on the effect of Notoginsenoside Ft1, a saponin with effect in promoting platelet aggregation.

Key Findings: According to the present study, Notoginsenoside Ft1 cannot stimulate platelet aggregation independently. Read More

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http://dx.doi.org/10.1111/jphp.13057DOI Listing
December 2018

Salvianolic acid B inhibits the development of diabetic peripheral neuropathy by suppressing autophagy and apoptosis.

J Pharm Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Department of Traditional Chinese Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Objectives: The aim of this study was to evaluate the neuroprotective effects of SalB on high glucose (HG)-induced excessive autophagy and apoptosis in vitro.

Methods: The proliferation and apoptosis of RSC96 cells were determined using the MTT assay and flow cytometry, respectively. Western blot analysis was performed to examine the expression of autophagy and apoptosis-related proteins. Read More

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http://dx.doi.org/10.1111/jphp.13044DOI Listing
December 2018

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review.

J Pharm Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Programa de Pós-graduação em Ciências Aplicadas à Saúde, Universidade Federal de Sergipe, Lagarto, Sergipe, Brazil.

Objectives: The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.13054
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http://dx.doi.org/10.1111/jphp.13054DOI Listing
December 2018
2 Reads

Suppression of TLR4 by miR-448 is involved in Diabetic development via regulating Macrophage polarization.

J Pharm Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Changzhou Wujin People's Hospital, Changzhou, China.

Objectives: Lipopolysaccharide (LPS) contributed to the development and progression of type 2 diabetes mellitus (T2D), while TLR4 is reported to mediate the LPS-induced inflammation in macrophages. However, the potential molecular mechanisms for TLR4-mediated macrophages activation in T2D have not yet to be fully clarified.

Methods: Type 2 diabetes models in C57BL/6J mice were generated by a combination administration of streptozotocin (STZ) and a high-fat diet (HFD). Read More

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http://dx.doi.org/10.1111/jphp.13048DOI Listing
December 2018

Study of nuclear factor-2 erythroid related factor-2 activator, berberine, in paclitaxel induced peripheral neuropathy pain model in rats.

J Pharm Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmacology, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Objectives: The role of nuclear factor-2 erythroid related factor-2 (Nrf2) activator, berberine (BBR), has been established in rat model of streptozotocin induced diabetic neuropathy. Around 30-40% of cancer patients, on paclitaxel (PTX) chemotherapy develop peripheral neuropathy. The present study was contemplated with the aim of establishing the neuropathy preventive role of BBR, in paclitaxel induced peripheral neuropathy model in rats. Read More

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http://dx.doi.org/10.1111/jphp.13047DOI Listing
December 2018

St John's wort (Hypericum perforatum L.): botanical, chemical, pharmacological and clinical advances.

J Pharm Pharmacol 2019 Jan;71(1):1-3

Discipline of Pharmacology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/jphp.13053DOI Listing
January 2019

Pharmacokinetic and pharmacodynamic studies of pregabalin suppositories based on pharmacological research.

J Pharm Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

Pharmaceutical Common Achievement Tests Organization, Tokyo, Japan.

Objectives: As commercially available pregabalin preparations are limited to oral administration, it is impossible to use it as an adjuvant analgesic for neuropathic cancer-related pain in terminally ill cancer patients with oral feeding difficulties. The objective of this study was to develop a pregabalin suppository to be available at hospitals.

Methods: Pregabalin suppositories were prepared using bases comprising six different compositions of Witepsol H-15, Witepsol S-55, and Witepsol E-75. Read More

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http://dx.doi.org/10.1111/jphp.13051DOI Listing
December 2018

Curcumin and a hemi-analogue with improved blood-brain barrier permeability protect against amyloid-beta toxicity in Caenorhabditis elegans via SKN-1/Nrf activation.

J Pharm Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Objectives: This study aims to investigate the blood-brain barrier (BBB) permeability of curcumin analogues with shortened linkers and their ability to protect against amyloid-beta toxicity in a whole organism model.

Method: Four curcumin analogues were synthesized. These analogues and curcumin were evaluated for their BBB permeability in the parallel artificial membrane permeability assay. Read More

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http://dx.doi.org/10.1111/jphp.13052DOI Listing
December 2018

Quercetin and 3-O-methylquercetin in vitro skin layers permeation/retention from hydrogels: why only a methoxy group difference determines different behaviors?

J Pharm Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objectives: The present study was designed to verify if quercetin (QCT), a flavonoid with antioxidant and antiviral activity, and 3-O-methylquercetin (3OMQ), a quercetin C3-methoxylated derivative, present differences in their behavior against complexation with β-cyclodextrin (β-CD) and the corresponding permeation/retention trhough porcine ear skin, when incorporated into hydroxypropyl methylcellulose (HPMC) or chitosan (CS) hydrogels.

Methods: The influence of β-CD on the skin permeation/retention of QCT and 3OMQ from hydrogels is comparatively evaluated for both flavonoids using porcine ear skin in Franz cells model. The properties of the two flavonoids using the semi-empirical method Recife Model was studied. Read More

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http://dx.doi.org/10.1111/jphp.13050DOI Listing
December 2018
1 Read

Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology.

J Pharm Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmaceutics and Drug Delivery, The University of Mississippi School of Pharmacy, University, MS, USA.

Objectives: To investigate the effects of formulation composition on the physico-chemical and drug release properties of mucoadhesive buccal films prepared by melt extrusion technology, using a response surface methodology.

Methods: Salbutamol sulphate, an antiasthmatic drug was used for this study. Klucel hydroxypropylcellulose (HPC) EF (film-forming polymer), Benecel hydroxypropylmethylcellulose (HPMC) K-15M (drug release retardant) and polyethylene glycol (PEG) 4500 (plasticiser) were the three independent factors utilised for the study. Read More

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http://dx.doi.org/10.1111/jphp.13046DOI Listing
November 2018

Effect of an anxiolytic botanical containing Souroubea sympetala and Platanus occidentalis on in-vitro diazepam human cytochrome P450-mediated metabolism.

J Pharm Pharmacol 2018 Nov 22. Epub 2018 Nov 22.

Department of Biology, University of Ottawa, Ottawa, ON, Canada.

Objectives: A novel anxiolytic natural health product (NHP) containing Souroubea sympetala and Platanus occidentalis is available for the companion animal market and is currently being developed for clinical evaluation. Addressing the risk of potential NHP-drug interactions, this study investigated S. sympetala and P. Read More

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http://dx.doi.org/10.1111/jphp.13045DOI Listing
November 2018
2 Reads
2.161 Impact Factor

Anomalous interaction of tri-acyl ester derivatives of uridine nucleoside with a l-α-dimyristoylphosphatidylcholine biomembrane model: a differential scanning calorimetry study.

J Pharm Pharmacol 2018 Nov 20. Epub 2018 Nov 20.

Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Catania, Italia.

Objectives: Uridine was conjugated with fatty acids to improve the drug lipophilicity and the interaction with phospholipid bilayers.

Methods: The esterification reaction using carbodiimides compounds as coupling agents and a nucleophilic catalyst allowed us to synthesize tri-acyl ester derivatives of uridine with fatty acids. Analysis of molecular interactions between these tri-acyl ester derivatives and l-α-dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV) - as a mammalian cell membrane model - have been performed by differential scanning calorimetry (DSC). Read More

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http://doi.wiley.com/10.1111/jphp.13038
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http://dx.doi.org/10.1111/jphp.13038DOI Listing
November 2018
6 Reads

Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models.

J Pharm Pharmacol 2018 Nov 19. Epub 2018 Nov 19.

Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Ceará, Brazil.

Objectives: To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine-induced schizophrenia model.

Methods: Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. Read More

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http://dx.doi.org/10.1111/jphp.13039DOI Listing
November 2018
4 Reads

Icariside II prevents hypertensive heart disease by alleviating endoplasmic reticulum stress via the PERK/ATF-4/CHOP signalling pathway in spontaneously hypertensive rats.

J Pharm Pharmacol 2018 Nov 20. Epub 2018 Nov 20.

Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China.

Objectives: Reducing endoplasmic reticulum stress (ERS)-induced cardiomyocyte apoptosis is a key strategy for preventing hypertensive heart disease. In our previous study, Icariside II can improve left ventricular remodelling in spontaneously hypertensive rats (SHRs). This study aims to determine whether Icariside II can exert its effect by inhibiting ERS-induced cardiomyocyte apoptosis via the PERK/ATF-4/CHOP signalling pathway. Read More

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http://doi.wiley.com/10.1111/jphp.13041
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http://dx.doi.org/10.1111/jphp.13041DOI Listing
November 2018
1 Read

The protective effects of Δ -tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia.

J Pharm Pharmacol 2018 Nov 14. Epub 2018 Nov 14.

Department of Medical Biology, Faculty of Cerrahpasa Medicine, Istanbul University, Istanbul, Turkey.

Objectives: A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Δ -tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The study aims to investigate the effects of THC treatment on inflammation, lipid profiles and oxidative stress in rat liver with hyperinsulinemia. Read More

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http://doi.wiley.com/10.1111/jphp.13042
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http://dx.doi.org/10.1111/jphp.13042DOI Listing
November 2018
2 Reads

Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus.

J Pharm Pharmacol 2018 Nov 12. Epub 2018 Nov 12.

Department of Neurology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, China.

Objectives: It has been proven that extracellular HMGB1 is involved in progression of neurologic disorders, such as stroke, traumatic brain injury, meningitis and epilepsy. Glycyrrhizin (GL) is a direct inhibitor of HMGB1, and blocks HMGB1 release into the extracellular. We aim in this study to investigate the neuroprotective effects of GL in a rat model after lithium-pilocarpine-induced status epilepticus (SE). Read More

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http://doi.wiley.com/10.1111/jphp.13040
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http://dx.doi.org/10.1111/jphp.13040DOI Listing
November 2018
5 Reads
2.161 Impact Factor

The PKCβ-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy.

J Pharm Pharmacol 2018 Nov 12. Epub 2018 Nov 12.

Institute of Nephrology, School of Medicine, Southeast University, Nanjing, China.

Objectives: Oxidative stress plays a critical role in the pathogenesis of diabetic nephropathy (DN). p66shc is closely related to oxidative stress. However, the exact mechanism of its involvement in diabetic nephropathy is poorly understood. Read More

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http://dx.doi.org/10.1111/jphp.13043DOI Listing
November 2018
2 Reads

Resveratrol glucuronidation in vitro: potential implications of inhibition by probenecid.

J Pharm Pharmacol 2018 Nov 12. Epub 2018 Nov 12.

Graduate Program in Pharmacology and Drug Development, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.

Objectives: Resveratrol is a naturally occurring antioxidant with therapeutic potential in prevention and treatment of neoplastic disease and other human disorders. However, net clearance of resveratrol in humans is very high, mainly due to glucuronide conjugation. This leads to extensive presystemic extraction and low plasma concentrations after oral dosage. Read More

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http://dx.doi.org/10.1111/jphp.13037DOI Listing
November 2018
8 Reads

The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa.

J Pharm Pharmacol 2018 Nov 8. Epub 2018 Nov 8.

Institute of Bioprocess Engineering and Pharmaceutical Technology, Technische Hochschule Mittelhessen, Giessen, Germany.

Objectives: The objective of this study was to investigate the therapeutic potential of the insect metalloproteinase inhibitor (IMPI) from Galleria mellonella, the only known specific inhibitor of M4 metalloproteinases.

Methods: The fusion protein IMPI-GST (glutathione-S-transferase) was produced by fermentation in Escherichia coli and was tested for its ability to inhibit the proteolytic activity of the M4 metalloproteinases thermolysin and Pseudomonas elastase (PE), the latter a key virulence factor of the wound-associated and antibiotic-resistant pathogen Pseudomonas aeruginosa. We also tested the ability of IMPI to inhibit the secretome (Sec) of a P. Read More

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http://doi.wiley.com/10.1111/jphp.13034
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http://dx.doi.org/10.1111/jphp.13034DOI Listing
November 2018
4 Reads

Regional difference in intestinal drug absorption as a measure for the potential effect of P-glycoprotein efflux transporters.

J Pharm Pharmacol 2018 Oct 26. Epub 2018 Oct 26.

Department of Pharmaceutical Technology, College of Pharmacy, University of Tanta, Tanta, Egypt.

Objectives: The aim of this research was to assess regional difference in the intestinal absorption of ranitidine HCl as an indicator for the potential effect of P-glycoprotein (P-gp) efflux transporters.

Methods: In situ rabbit intestinal perfusion was used to investigate absorption of ranitidine HCl, a substrate for P-gp efflux from duodenum, jejunum, ileum and colon. This was conducted both in the presence and absence of piperine as P-gp inhibitor. Read More

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http://dx.doi.org/10.1111/jphp.13036DOI Listing
October 2018

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines.

J Pharm Pharmacol 2018 Oct 26. Epub 2018 Oct 26.

Department of Plastic Surgery, Faculty of Medicine, Assiut University, Assiut, Egypt.

Objectives: To determine the efficacy of Corchorus olitorius (C. olitorius) leaf extract in the prevention of metabolic syndrome induced in rats by high-fat diet (HFD) and compare it with that of orlistat.

Methods: Phytochemical analysis was performed. Read More

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http://doi.wiley.com/10.1111/jphp.13032
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http://dx.doi.org/10.1111/jphp.13032DOI Listing
October 2018
8 Reads

Acrofolione A and B, acetophenone dimers from Acronychia pendunculata, induce an apoptotic effect on human NALM-6 pre-B cell leukaemia cells.

J Pharm Pharmacol 2018 Oct 25. Epub 2018 Oct 25.

School of Sports and Health Science, Tokai Gakuen University, Miyoshi, Aichi, Japan.

Objectives: We investigated the apoptotic activities of acrofolione A (1) and B (2) isolated from Acronychia pedunculata against a human pre-B cell leukaemia cell line (NALM-6) to explore the apoptosis-related signalling molecules targeted by 1 and 2.

Methods: The apoptosis effects of 1 and 2 in NALM-6 cells were investigated by TUNEL staining, annexin V, mitochondria membrane potential and caspase 3/7 activity. We carried out a protein array to explore the signalling molecules involved in apoptosis comprehensively. Read More

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http://dx.doi.org/10.1111/jphp.13035DOI Listing
October 2018

Combined use of arginase and dichloroacetate exhibits anti-proliferative effects in triple negative breast cancer cells.

J Pharm Pharmacol 2018 Oct 25. Epub 2018 Oct 25.

Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, China.

Objectives: Drug combination in cancer therapy aims to achieve synergistic therapeutic effect, reduced drug dosage, reduced drug toxicity and minimizes or delays the induction of drug resistance. In the present study, we investigated the anticancer effects of the combination of two metabolic modulators, dichloroacetate (DCA) and bacillus caldovelox arginase (BCA) (or pegyated human arginase (HA)).

Methods: The combination treatments were evaluated in MCF-7 and MDA-MB 231 cells as well as in MDA-MB 231 breast cancer xenograft model. Read More

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http://doi.wiley.com/10.1111/jphp.13033
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http://dx.doi.org/10.1111/jphp.13033DOI Listing
October 2018
4 Reads

The influence of SLC6A3 and DRD2 polymorphisms on levodopa-therapy in patients with sporadic Parkinson's disease.

J Pharm Pharmacol 2018 Oct 23. Epub 2018 Oct 23.

Postgraduate Program of Applied Cellular and Molecular Biology, University of Pernambuco (UPE), Recife, PE, Brazil.

Objectives: The aim of this study was to evaluate a possible relationship between DRD2/ANKK1 (rs1800497) and SLC6A3/DAT1 (rs28363170) gene polymorphisms with the response to levodopa (L-DOPA)-therapy in patients with Parkinson's disease (PD).

Methods: One hundred and ninety-five patients with idiopathic PD were investigated. Patients were genotyped for rs1800497 and rs28363170 polymorphisms using PCR-RFLP. Read More

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http://dx.doi.org/10.1111/jphp.13031DOI Listing
October 2018

Evaluation of inhaled recombinant human insulin dry powders: pharmacokinetics, pharmacodynamics and 14-day inhalation.

J Pharm Pharmacol 2018 Oct 15. Epub 2018 Oct 15.

Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.

Objectives: The present study was designed to assess the pharmacokinetic and pharmacodynamic performance of inhaled recombinant human insulin (rh-insulin) dry powders together with their safety profiles after 14-day inhalation.

Methods: In the pharmacokinetic and pharmacodynamic study, pulmonary surfactant (PS)-loaded and phospholipid hexadecanol tyloxapol (PHT)-loaded rh-insulin dry powders were intratracheally administered to male rats at the dose of 20 U/kg. Novolin R was used as control. Read More

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http://dx.doi.org/10.1111/jphp.13026DOI Listing
October 2018
2 Reads

Flavonoid composition, cellular antioxidant activity and (myelo)peroxidase inhibition of a Bryonia alba L. (Cucurbitaceae) leaves extract.

J Pharm Pharmacol 2018 Oct 15. Epub 2018 Oct 15.

Center for Interdisciplinary Research on Medicines, Laboratory of Pharmacognosy, University of Liège, Liège, Belgium.

Objectives: The aim of the present study consisted in the isolation of flavonoids from the leaves of Bryonia alba L. and evaluation of their antioxidant activity and inhibition on peroxidase-catalysed reactions.

Methods: Flavonoids were isolated by preparative HPLC-DAD and their structures were elucidated by MS and NMR. Read More

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http://doi.wiley.com/10.1111/jphp.13025
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http://dx.doi.org/10.1111/jphp.13025DOI Listing
October 2018
4 Reads

Reduced folate carrier-mediated methotrexate transport in human distal lung epithelial NCl-H441 cells.

J Pharm Pharmacol 2018 Oct 15. Epub 2018 Oct 15.

Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

Objectives: We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells. Therefore, we examined MTX uptake in NCl-H441 (H441) cells, another in vitro alveolar epithelial model, focusing on the localization of RFC in the present study.

Methods: Transport function of RFC in H441 cells was studied using [ H]MTX. Read More

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http://dx.doi.org/10.1111/jphp.13022DOI Listing
October 2018

Crystal structure and anti-inflammatory and anaphylactic effects of andrographlide sulphonate E in Xiyanping, a traditional Chinese medicine injection.

J Pharm Pharmacol 2018 Oct 15. Epub 2018 Oct 15.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.

Objectives: Andrographlide sulphonate E, namely sodium 9-dehydro-17-hydro-andrographolide-19-yl sulphate, was one of the major ingredients of Xiyanping injection. The present study aimed to demonstrate its suitability as a reference standard for use of quality control of this traditional Chinese medicine preparation made from andrographlide that has been widely used to treat various infectious diseases.

Methods: The stable crystals were prepared for unambiguous elucidation of the chemical structure by comprehensive spectral and thermal analysis. Read More

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http://doi.wiley.com/10.1111/jphp.13028
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http://dx.doi.org/10.1111/jphp.13028DOI Listing
October 2018
10 Reads

Cytotoxic activity and molecular targets of atractylodin in cholangiocarcinoma cells.

J Pharm Pharmacol 2018 Oct 15. Epub 2018 Oct 15.

Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Klongluang, Thailand.

Objectives: To evaluate the cytotoxic activity of atractylodin and its potential effects on heme oxygenase (HO)-1 production, STAT1/3 phosporylation and major NF-κB protein expression in the cholangiocarcinoma-associated cell line CL-6.

Methods: Standard MTT assay was used for accessing antiproliferative activity on CL-6 cells. Normal human embryonic fibroblast (OUMS) cell was taken as control cell line. Read More

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http://doi.wiley.com/10.1111/jphp.13024
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http://dx.doi.org/10.1111/jphp.13024DOI Listing
October 2018
7 Reads

Chemical profile, antioxidant, and enzyme inhibitory properties of two Scutellaria species: S. orientalis L. and S. salviifolia Benth.

J Pharm Pharmacol 2018 Oct 10. Epub 2018 Oct 10.

Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit, Mauritius.

Objectives: This study investigates into the biological effects of solvent extracts (ethyl acetate, methanol, and water) of Scutellaria orientalis L. and Scutellaria salviifolia Benth. based on its enzyme inhibitory activity and antioxidant ability together with the screening of bioactive compounds. Read More

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http://dx.doi.org/10.1111/jphp.13030DOI Listing
October 2018

Antiplasmodial activity and cytotoxicity, isolation of active alkaloids, and dereplication of Xylopia sericea leaves ethanol extract by UPLC-DAD-ESI-MS/MS.

J Pharm Pharmacol 2018 Oct 10. Epub 2018 Oct 10.

Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objectives: To assess the antiplasmodial activity of the ethanol extract of Xylopia sericea leaves, Annonaceae, often associated with antimalarial use and to perform a bioguided isolation of active compounds.

Methods: Dereplication of ethanol extract by the UPLC-DAD-ESI-MS/MS technique allowed the identification of the major constituents, isolation and identification of alkaloids. The antiplasmodial and cytotoxic activity of the extract, fractions and isolated compounds was evaluated against the chloroquine-resistant W2 strain Plasmodium falciparum and HepG2 cells, respectively. Read More

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http://doi.wiley.com/10.1111/jphp.13029
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http://dx.doi.org/10.1111/jphp.13029DOI Listing
October 2018
3 Reads

Effect of Radix isatidis polysaccharide on alleviating insulin resistance in type 2 diabetes mellitus cells and rats.

J Pharm Pharmacol 2018 Oct 9. Epub 2018 Oct 9.

Department of Pharmacology, Medical College, Yangzhou University, Yangzhou, China.

Objectives: The objective of this paper was to explore the effects of Radix isatidis polysaccharide (RIP) extracted from Radix isatis on alleviating insulin resistance.

Methods: The insulin resistance models of 3T3-L1 preadipocytes and type 2 diabetic rats were established to evaluate the insulin resistance activity of RIP.

Key Findings: Radix isatidis polysaccharide within the concentration range of 25-100 μg/ml could reduce cell supernatant glucose and TNF-α levels (P < 0. Read More

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http://dx.doi.org/10.1111/jphp.13023DOI Listing
October 2018
1 Read

Anti-alcohol liver disease effect of Gentianae macrophyllae extract through MAPK/JNK/p38 pathway.

J Pharm Pharmacol 2018 Oct 9. Epub 2018 Oct 9.

Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.

Objectives: The hepatoprotective effect of Gentianae macrophyllae root extract (GME) on alcoholic liver disease (ALD) was evaluated through ethanol induced ALD animal model.

Methods: Mice were randomly divided into control normal group (10 mice), ethanol-induced ALD model group (10 mice) and GME plus ethanol group (30 mice). Mice in model group were given intragastric administration with 50% (v/v) ethanol aqueous solution (200 μl for each) once daily for 19 days. Read More

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http://doi.wiley.com/10.1111/jphp.13027
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http://dx.doi.org/10.1111/jphp.13027DOI Listing
October 2018
1 Read
2.160 Impact Factor

Paeonia lactiflora Pall. regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats.

J Pharm Pharmacol 2018 Dec 14;70(12):1675-1687. Epub 2018 Sep 14.

China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing, China.

Objectives: Cholestasis is a critical risk factor for severe hepatic disease or cirrhosis. The anti-inflammatory effect of Paeonia lactiflora Pall. (PLP), named Chishao in traditional Chinese medicine (TCM), on alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model was tried to be elucidated in this research. Read More

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http://dx.doi.org/10.1111/jphp.13008DOI Listing
December 2018

The impact of Cymbopogon martinii essential oil on Cutibacterium (formerly Propionibacterium) acnes strains and its interaction with keratinocytes.

J Pharm Pharmacol 2018 Dec 13;70(12):1688-1699. Epub 2018 Sep 13.

Department of Microbiology and Immunology, Institute of Biosciences of Botucatu, UNESP - Campus de Botucatu, Botucatu, SP, Brazil.

Objectives: The human skin microbiota is mainly composed of bacteria belonging to the genera Staphylococcus, Cutibacterium, Micrococcus and Corynebacterium, but on the skin of the face and back, ca. 50% of the total microbiota is represented by the bacterium Cutibacterium acnes. The aim of this research was to evaluate the impact of C. Read More

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http://doi.wiley.com/10.1111/jphp.13011
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http://dx.doi.org/10.1111/jphp.13011DOI Listing
December 2018
5 Reads

Relationship between MRGPRX2 and pethidine hydrochloride- or fentanyl citrate-induced LAD2 cell degranulation.

J Pharm Pharmacol 2018 Dec 6;70(12):1596-1605. Epub 2018 Sep 6.

School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Objectives: Pethidine hydrochloride (PH) and fentanyl citrate (FC) are opioid receptor agonists commonly used to treat pain clinically. PH and FC have been reported to have a high potential for pseudoallergic effects, but the underlying mechanism has not been well studied. MRGPRX2 is a novel atypical opioid receptor that is mainly expressed in human mast cells and considered to mediate drug-induced pseudoallergic reactions. Read More

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http://dx.doi.org/10.1111/jphp.13009DOI Listing
December 2018
4 Reads
2.161 Impact Factor

Self-emulsifying drug delivery systems and cationic surfactants: do they potentiate each other in cytotoxicity?

J Pharm Pharmacol 2018 Sep 25. Epub 2018 Sep 25.

Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Chemistry and Biomedicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria.

Objectives: The aim of this study was to evaluate the cytotoxicity of self-emulsifying drug delivery systems (SEDDS) containing five different cationic surfactants.

Methods: Cationic surfactants were added in a concentration of 1% and 5% (m/m) to SEDDS comprising 30% Capmul MCM, 30% Captex 355, 30% Cremophor EL and 10% propylene glycol. The resulting formulations were characterized in terms of size, zeta potential, in-vitro haemolytic activity and toxicity on Caco-2 via MTT assay and lactate dehydrogenase release assay. Read More

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http://dx.doi.org/10.1111/jphp.13021DOI Listing
September 2018
1 Read

PPARα-independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling.

J Pharm Pharmacol 2018 Dec 25;70(12):1630-1642. Epub 2018 Sep 25.

Medical School of Ningbo University, Ningbo, China.

Objectives: Metabolic syndrome (MS) is the concurrence of at least three of five medical conditions: obesity, high blood pressure, insulin resistance, high serum triglyceride (TG) and low serum high-density lipoprotein levels. While fibrates are used to treat disorders other than the lowering serum TG, the mechanism by which fibrates decrease MS has not been established.

Methods: In this study, wild-type and Ppara-null mice fed a medium-fat diet (MFD) were administered gemfibrozil and fenofibrate for 3 months respectively, to explore the effect and action mechanism. Read More

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http://dx.doi.org/10.1111/jphp.13014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281295PMC
December 2018
3 Reads

Potential P-glycoprotein-mediated herb-drug interaction of phyllanthin at the intestinal absorptive barrier.

J Pharm Pharmacol 2018 Sep 25. Epub 2018 Sep 25.

Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

Objectives: This study investigated the absorptive potential of phyllanthin across the polarized Caco-2 monolayers and the potential role of phyllanthin in P-glycoprotein (P-gp)-mediated drug interaction.

Methods: The absorptive potential of phyllanthin was predicted from its apparent permeability (P ) across the Caco-2 monolayers under the pH gradient condition (pH 6.5 -7. Read More

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http://dx.doi.org/10.1111/jphp.13019DOI Listing
September 2018
1 Read

Antidiabetic potential of Musa spp. inflorescence: a systematic review.

J Pharm Pharmacol 2018 Dec 25;70(12):1583-1595. Epub 2018 Sep 25.

Department of Pharmacy, Federal University of Paraná, Curitiba, Brazil.

Objectives: Extracts of parts Musa spp. have been used for the treatment of various diseases in traditional medicine. Studies have shown that these extracts have hypoglycaemic properties. Read More

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http://dx.doi.org/10.1111/jphp.13020DOI Listing
December 2018
4 Reads

Benzyl sulforaphane is superior to sulforaphane in inhibiting the Akt/MAPK and activating the Nrf2/ARE signalling pathways in HepG2 cells.

J Pharm Pharmacol 2018 Dec 25;70(12):1643-1653. Epub 2018 Sep 25.

School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou, Jiangsu, China.

Objectives: Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has been reported to own anticarcinogenic, antiinflammatory and cancer chemopreventive properties. Benzyl sulforaphane (BSFN) was a derivative of SFN which was designed and synthesized by our laboratory. Here, the cancer prevention and anticancer effects of BSFN on human hepatoma (HepG2) cells were investigated. Read More

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http://dx.doi.org/10.1111/jphp.13015DOI Listing
December 2018
8 Reads

Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats.

J Pharm Pharmacol 2018 Dec 25;70(12):1654-1661. Epub 2018 Sep 25.

Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.

Objectives: The aim of this experiment was mainly to examine the effects of intrathecally injected doxylamine and triprolidine, two antihistamine drugs spinal motor and sensory functions.

Methods: After intrathecally injecting the rats with five different doses, the dose-response curves of spinal sensory and motor block with doxylamine and triprolidine were constructed. In comparison with the local anaesthetic mepivacaine, the quality and duration of spinal anaesthesia with doxylamine or triprolidine were conducted. Read More

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http://doi.wiley.com/10.1111/jphp.13017
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http://dx.doi.org/10.1111/jphp.13017DOI Listing
December 2018
9 Reads
2.160 Impact Factor

Total flavones of Rhododendron simsii Planch flower protect isolated rat heart from ischaemia-reperfusion injury and its mechanism of UTR-RhoA-ROCK pathway inhibition.

J Pharm Pharmacol 2018 Dec 25;70(12):1713-1722. Epub 2018 Sep 25.

Department of Pharmacology, Anhui Medical University, Hefei, Anhui, China.

Objectives: Total flavones of Rhododendron simsii Planch flower (TFR) are an effective part extracted from the flower. The present study was designed to investigate the protective effect of TFR in isolated rat heart following global ischaemia-reperfusion and the possible underlying mechanisms.

Methods: Langendorff perfusion apparatus was used to perfuse isolated rat heart which was subjected to global ischaemia-reperfusion. Read More

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http://doi.wiley.com/10.1111/jphp.13016
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http://dx.doi.org/10.1111/jphp.13016DOI Listing
December 2018
12 Reads

The efficacy of microemulsion-based delivery to improve vitamin E properties: evaluation of the antinociceptive, antioxidant, antidepressant- and anxiolytic-like activities in mice.

J Pharm Pharmacol 2018 Dec 25;70(12):1723-1732. Epub 2018 Sep 25.

Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica (LaFarBio), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil.

Objectives: A microemulsion-based delivery system was designed to improve vitamin E (VE) properties, and its antinociceptive, antioxidant, antidepressant- and anxiolytic-like activities in mice were evaluated.

Methods: Male Swiss mice received, by intragastric route, canola oil (20 ml/kg), blank microemulsion (B-ME) (20 ml/kg), VE free (VE-F) (200 mg/kg) or VE microemulsion (VE-ME) (200 mg/kg). In acute treatment, a single dose of treatments was administrated and 30 min after behavioural tests were performed. Read More

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http://dx.doi.org/10.1111/jphp.13018DOI Listing
December 2018

Synthesis of new anticancer and anti-inflammatory isoxazolines and aziridines from the natural (-)-deltoin.

J Pharm Pharmacol 2018 Dec 19;70(12):1700-1712. Epub 2018 Sep 19.

Laboratory of IMRCP UMR CNRS 5623, Faculty of Pharmacy Toulouse, Paul-Sabatier University, University of Toulouse, Toulouse, France.

Objectives: This work describes the synthesis, the bioactivity and the structure-activity relationship of new derivatives from a natural coumarin.

Methods: (-)-Deltoin 1 and the corresponding isoxazolines and aziridines were characterized by spectroscopic means. The cytotoxic (HTC-116, IGROV-1 and OVCAR-3 cancer cell lines) and 5-lipoxygenase activity of (-)-deltoin 1 and its structural analogues have been evaluated. Read More

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http://doi.wiley.com/10.1111/jphp.13013
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http://dx.doi.org/10.1111/jphp.13013DOI Listing
December 2018
9 Reads

The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review.

J Pharm Pharmacol 2018 Sep 11. Epub 2018 Sep 11.

Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.

Objectives: Using the type of meal and dosing conditions suggested by regulatory agencies as a basis, this review has two specific objectives: first, to summarize our understanding on the impact of food intake on luminal environment and drug product performance and second, to summarize the usefulness and limitations of available in vitro and in silico methodologies for the evaluation of drug product performance after food intake.

Key Findings: Characterization of the luminal environment and studies evaluating product performance in the lumen, under conditions suggested by regulatory agencies for simulating the fed state, are limited. Various in vitro methodologies have been proposed for evaluating drug product performance in the fed state, but systematic validation is lacking. Read More

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http://doi.wiley.com/10.1111/jphp.12999
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http://dx.doi.org/10.1111/jphp.12999DOI Listing
September 2018
2 Reads

Investigation of potent anticarcinogenic activity of 1, 3-diarylpyrazole acrylamide derivatives in vitro.

J Pharm Pharmacol 2018 Dec 10;70(12):1619-1629. Epub 2018 Sep 10.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey.

Objectives: Pyrazole derivatives are pharmacologically powerful agents pointing at new horizons in the development of anticancer therapies. In this study, anticarcinogenic potential of a series of pyrazole-acrylamide derivatives has been investigated in mesothelial, malignant mesothelioma and lung cancer cell lines.

Methods: The effect of compounds on the viability of cells and the distribution of cell cycle were examined through MTS assay and PI staining, respectively. Read More

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http://doi.wiley.com/10.1111/jphp.13012
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http://dx.doi.org/10.1111/jphp.13012DOI Listing
December 2018
11 Reads

Tannins from Terminalia chebula fruits attenuates GABA antagonist-induced anxiety-like behaviour via modulation of neurotransmitters.

J Pharm Pharmacol 2018 Dec 10;70(12):1662-1674. Epub 2018 Sep 10.

Defence Food Research Laboratory, Applied Nutrition Division, DRDO, Mysore, India.

Objectives: This article investigates the anxiolytic activity of Terminalia chebula tannin-rich extract against picrotoxin (PTX; GABA antagonist)-induced anxiety in mice model.

Methods: Anxiolytic activity was studied by elevated plus maze (EPM), open field test (OFT), light/dark box test (LDT) and Vogel's conflict test (VCT). Electroencephalogram (EEG) was performed to know the changes in brain activity instigated by GABA antagonist. Read More

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http://dx.doi.org/10.1111/jphp.13007DOI Listing
December 2018
15 Reads
2.161 Impact Factor

Phytochemistry and pharmacology of the genus Entandrophragma over the 50 years from 1967 to 2018: a 'golden' overview.

J Pharm Pharmacol 2018 Nov 5;70(11):1431-1460. Epub 2018 Sep 5.

Department of Chemistry, Higher Teacher Training College, University of Yaounde I, Yaounde, Cameroon.

Objectives: For centuries, the genus Entandrophragma (Meliaceae), endemic to Africa, has been used in traditional medicine for the treatment of several illnesses. This review deals with large range of phytochemicals from the genus Entandrophragma and their pharmacological potentials covering the period from 1967 to 2018.

Key Findings: Phytochemical investigations of the genus Entandrophragma led to the report of about 166 secondary metabolites which have been thoroughly summarized herein including some of their semisynthetic derivatives obtained from chemical transformations as well as their biological activities in the medicinal and agricultural domains. Read More

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http://dx.doi.org/10.1111/jphp.13005DOI Listing
November 2018
1 Read