623 results match your criteria Journal of Pharmacy and Pharmacological Research [Journal]


Molecular targets of fenofibrate in the cardiovascular-renal axis: A unifying perspective of its pleiotropic benefits.

Pharmacol Res 2019 Apr 7;144:132-141. Epub 2019 Apr 7.

Periyar Maniammai Institute of Science & Technology (Deemed to be University), Vallam, 613403, India.

The activation of peroxisome proliferator-activated receptor α (PPARα) is a key pharmacological drug target for dyslipidemic management. Dyslipidemia is associated with abnormal serum lipid profiles viz. elevated total cholesterol, high triglyceride, elevated low-density lipoprotein cholesterol, and reduced high-density lipoprotein cholesterol levels. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.025DOI Listing
April 2019
1 Read

Hydrogen sulfide stabilizes atherosclerotic plaques in apolipoprotein E knockout mice.

Pharmacol Res 2019 Apr 5;144:90-98. Epub 2019 Apr 5.

Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China; School of Pharmacy, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China. Electronic address:

Hydrogen sulfide gas (HS) has protective effects in the cardiovascular system that includes preventing the development of atherosclerosis when tested in several in vivo models. Plaque instability is a major risk factor for thromboembolism, myocardial infarction, and stroke, so we examined if HS can promote plaque stability and the potential underlying mechanisms. Apolipoprotein E knockout mice fed an atherogenic diet were administered the exogenous HS donor sodium hydrosulfide (NaHS) or pravastatin as a positive control daily for 14 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183186
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http://dx.doi.org/10.1016/j.phrs.2019.04.006DOI Listing
April 2019
1 Read

Carbon nanomaterials and amyloid-beta interactions: potentials for the detection and treatment of Alzheimer's disease?

Pharmacol Res 2019 Mar 31;143:186-203. Epub 2019 Mar 31.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Carbon-based nanomaterials have unique physicochemical properties relevant to the diagnosis and treatment of various diseases. There have been many reports indicating that carbon nanomaterials (CNMs) can interact and perturb biomolecules such as proteins and amyloid structures. This review is an attempt to reflect the role of CNMs in the treatment and detection of Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.023DOI Listing
March 2019
3 Reads

Dysregulation of the Hippo pathway signaling in aging and cancer.

Pharmacol Res 2019 Mar 22;143:151-165. Epub 2019 Mar 22.

Department of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain. Electronic address:

Human beings are facing emerging degenerative and cancer diseases, in large part, as a consequence of increased life expectancy. In the near future, researchers will have to put even more effort into fighting these new challenges, one of which will be prevention of cancer while continuing to improve the aging process through this increased life expectancy. In the last few decades, relevance of the Hippo pathway on cancer has become an important study since it is a major regulator of organ size control and proliferation. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.018DOI Listing
March 2019
1 Read

A review of gene- and cell-based therapies for familial hypercholesterolemia.

Pharmacol Res 2019 Mar 22;143:119-132. Epub 2019 Mar 22.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder caused by an impaired receptor-mediated low-density lipoprotein (LDL) removal from the circulation, mainly due to disruptive autosomal co-dominant mutations in the LDL receptor (LDLr) gene, but also less frequently in the apolipoprotein B100 (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. A rare form of autosomal recessive FH has been also described due to LDLr adaptor protein 1 (LDLRAP1) gene mutations. FH is characterized by very high levels of plasma LDL cholesterol associated with the high incidence of premature atherosclerotic cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.016DOI Listing
March 2019
1 Read

Adenylyl cyclase 7 and neuropsychiatric disorders: A new target for depression?

Pharmacol Res 2019 Mar 20;143:106-112. Epub 2019 Mar 20.

Department of Pharmaceutical Sciences, Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL 33416, United States.. Electronic address:

Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Humans express nine isoforms of membranous ACs and a soluble AC. Studies with genetic knockout or overexpression rodent models have indicated that AC isoforms may be targeted to achieve specific therapeutic outcomes. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.015DOI Listing
March 2019
3 Reads

Novel urokinase-plasminogen activator inhibitor SPINK13 inhibits growth and metastasis of hepatocellular carcinoma in vivo.

Pharmacol Res 2019 Mar 9;143:73-85. Epub 2019 Mar 9.

Medical School of Chinese PLA & Department of Clinical Laboratory, Medical Laboratory Center, Chinese PLA General Hospital, Beijing 100853, PR China. Electronic address:

Advanced hepatocellular carcinoma (HCC) is a highly aggressive malignancy that is a serious threat to the public health system of China. Urokinase-plasminogen activator (uPA) can promote the invasive growth and metastasis of HCC cells by activating matrix metalloproteinases (MMPs), leading to the breakage of the extra-cellular matrix. uPA is a promising target for advanced HCC treatment. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.009DOI Listing

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases.

Pharmacol Res 2019 Mar 7;143:58-72. Epub 2019 Mar 7.

Department of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain. Electronic address:

Aging is a complex process. It is considered a risk factor for several diseases such as cancer, neurodegenerative diseases, cardiovascular diseases, and diabetes, most of which have an oxidative and inflammatory base. Given that life expectancy is increasing, there is a present interest in the search for anti-aging strategies that allow a healthy aging. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.005DOI Listing
March 2019
1 Read
4.408 Impact Factor

Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats.

Pharmacol Res 2019 Apr 28;142:283-293. Epub 2019 Feb 28.

Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. Electronic address:

The 3,4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug, which ultimately leads to serotonergic (5-HT) neurotoxicity and psychiatric disorders. Previous in vitro studies have consistently demonstrated that MDMA provokes autophagic activation, as well as damage of 5-HT axons and nerve fibers. So far, whether autophagy, a well-conserved cellular process that is critical for cell fate, also participates in MDMA-induced neurotoxicity in vivo remains elusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183130
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http://dx.doi.org/10.1016/j.phrs.2019.02.026DOI Listing
April 2019
6 Reads

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia.

Pharmacol Res 2019 Apr 25;142:237-250. Epub 2019 Feb 25.

Physiology, Augusta University, Augusta, GA, United States; Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States. Electronic address:

Diabetes increases the risk and worsens the progression of cognitive impairment via the greater occurrence of small vessel disease and stroke. Yet, the underlying mechanisms are not fully understood. It is now accepted that cardiovascular health is critical for brain health and any neurorestorative approaches to prevent/delay cognitive deficits should target the conceptual neurovascular unit (NVU) rather than neurons alone. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.035DOI Listing
April 2019
3 Reads

Gut microbiota, a new frontier to understand traditional Chinese medicines.

Pharmacol Res 2019 Apr 25;142:176-191. Epub 2019 Feb 25.

Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

As an important component of complementary and alternative medicines, traditional Chinese medicines (TCM) are gaining more and more attentions around the world because of the powerful therapeutic effects and less side effects. However, there are still some doubts about TCM because of the questionable TCM theories and unclear biological active compounds. In recent years, gut microbiota has emerged as an important frontier to understand the development and progress of diseases. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.024DOI Listing
April 2019
3 Reads

Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization.

Pharmacol Res 2019 Apr 19;142:102-114. Epub 2019 Feb 19.

State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address:

Dihydrotanshinone (DHT), one of the major ingredients of Salvia miltiorrhiza Bunge (Danshen), displays many bioactivities. However, the activity and underlying mechanism of DHT in anti-inflammation have not yet been elucidated. In this study, we investigated the anti-inflammatory activity and molecular mechanism of action of DHT both in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.017DOI Listing
April 2019
2 Reads
4.408 Impact Factor

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.

Pharmacol Res 2019 Apr 19;142:127-139. Epub 2019 Feb 19.

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy. Electronic address:

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed primarily in nociceptors, mediates the action of proalgesic and inflammatory agents. Ibuprofen metabolism yields the reactive compound, ibuprofen-acyl glucuronide, which, like other TRPA1 ligands, covalently interacts with macromolecules. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.019DOI Listing

The therapeutic role of long non-coding RNAs in human diseases: A focus on the recent insights into autophagy.

Pharmacol Res 2019 Apr 8;142:22-29. Epub 2019 Feb 8.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Centre, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Long non-coding RNA (lncRNA) is a class of non-coding RNA with ≥200 nucleotides in length which are involved as critical regulators in various cellular processes. LncRNAs contribute to the development and progression of many human diseases. Autophagy is a key catabolic process which helps to maintain the cellular homeostasis through the decay of damaged or unwanted proteins and dysfunctional cytoplasmic organelles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618193017
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http://dx.doi.org/10.1016/j.phrs.2019.02.010DOI Listing
April 2019
7 Reads

Neuropharmacology, pharmacogenetics and pharmacogenomics of aggression: The zebrafish model.

Pharmacol Res 2019 Mar 29;141:602-608. Epub 2019 Jan 29.

School of Pharmacy, Southwest University, Chongqing, China; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Ural Federal University, Ekaterinburg, Russia; Granov's Russian Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia; Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia. Electronic address:

The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in neurobehavioral research. Aggression is a common symptom of many CNS disorders, has some genetic determinants and can be modulated pharmacologically in humans and animal model species. Mounting evidence suggests zebrafish as a useful tool to study neurobiology of aggression, and its pharmacological and genetic regulation. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.044DOI Listing
March 2019
2 Reads

Diabetic nephropathy: The regulatory interplay between epigenetics and microRNAs.

Pharmacol Res 2019 Mar 26;141:574-585. Epub 2019 Jan 26.

Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India. Electronic address:

Diabetic nephropathy (DN) is still one of the leading causes of end-stage renal disease despite the emergence of different therapies to counter the metabolic, hemodynamic and fibrotic pathways, implicating a prominent role of genetic and epigenetic factors in its progression. Epigenetics is the study of changes in the expression of genes which may be inheritable and does not involve a change in the genome sequence. Thrust areas of epigenetic research are DNA methylation and histone modifications. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.043DOI Listing
March 2019
3 Reads

Current evidence and future perspectives for curcumin and its analogues as promising adjuncts to oxaliplatin: state-of-the-art.

Pharmacol Res 2019 Mar 11;141:343-356. Epub 2019 Jan 11.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Curcumin is a multifunctional phytochemical that has documented anti-oxidant, anti-inflammatory and anti-tumor properties. The anti-tumor effect of curcumin has been widely investigated, both as a single ingredient and in combination with chemotherapeutic agents. Oxaliplatin is a third-generation platinum agent with established effectiveness in multiple malignancies including gastroesophageal, colorectal, pancreas, ovarian, breast and head and neck cancers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183122
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http://dx.doi.org/10.1016/j.phrs.2019.01.020DOI Listing
March 2019
10 Reads

Rev-erbα activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice.

Pharmacol Res 2019 Mar 11;141:310-318. Epub 2019 Jan 11.

Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, Guangzhou, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China. Electronic address:

REV-ERBα (NR1D1) is a nuclear heme receptor that controls many cellular processes including cell differentiation, lipid metabolism, and inflammatory responses. Although REV-ERBα has been also implicated in regulation of glucose homeostasis, the mechanism for this regulation remains unclear. Here we investigate a potential role of REV-ERBα in regulation of PCK1 (phosphoenolpyruvate carboxykinase 1), a rate-limiting enzyme in gluconeogenesis. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.010DOI Listing
March 2019
1 Read

Targeting Hedgehog signaling pathway: Paving the road for cancer therapy.

Pharmacol Res 2019 Mar 11;141:466-480. Epub 2019 Jan 11.

Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The Hedgehog pathway is essential for embryonic development but also for tissue and organ homeostasis in adult organisms. Activation of this pathway leads to the expression of target genes involved in proliferation, angiogenesis and stem cell self-renewal. Moreover, abnormal persistence of Hedgehog signaling is directly involved in a wide range of human cancers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183085
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http://dx.doi.org/10.1016/j.phrs.2019.01.014DOI Listing
March 2019
17 Reads
4.408 Impact Factor

A novel nanoformulation of PLGA with high non-ionic surfactant content improves in vitro and in vivo PTX activity against lung cancer.

Pharmacol Res 2019 Mar 8;141:451-465. Epub 2019 Jan 8.

Institute of Biopathology and Regenerative Medicine (IBIM9090325ER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain; Department of Anatomy and Embriology, Faculty of Medicine, University of Granada, 18071 Granada, Spain; Biosanitary Institute of Granada (ibs.GRANADA), SAS-University of Granada, 18014 Granada, Spain.

Paclitaxel (PTX), a chemotherapy agent widely used to treat lung cancer, is characterised by high toxicity, low bioavailability and the need to use of excipients with serious side effects that limit its use. Paclitaxel encapsulation into nanoparticles (NPs) generates drug pharmacokinetic and pharmacodynamic advantages compared to free PTX. In this context, a NP carrier formed from a copolymer of lactic acid and glycolic acid (PLGA) has demonstrated high biocompatibility and low toxicity and therefore being approved by FDA to be used in humans. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.013DOI Listing
March 2019
1 Read

Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids.

Pharmacol Res 2019 Mar 4;141:291-297. Epub 2019 Jan 4.

Curtin Health Innovation Research Institute, Curtin University, WA, Australia; School of Public Health, Faculty of Health Sciences, Curtin University, WA, Australia. Electronic address:

Type-2 diabetes (T2D) increases the risk of dementia by ˜5-fold, however the mechanisms by which T2D increases dementia risk remain unclear. Evidence suggests that the heightened inflammation and oxidative stress in T2D may lead to disruption of the blood-brain barrier (BBB), which precedes premature cognitive decline. Studies show that vascular-targeted anti-inflammatory treatments protect the BBB by attenuating neuroinflammation, and in some studies attenuate cognitive decline. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.009DOI Listing
March 2019
4 Reads
4.408 Impact Factor

α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress.

Pharmacol Res 2019 Mar 3;141:214-223. Epub 2019 Jan 3.

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Senescence is a process characterized by an irreversible growth arrest in cells and induced by oxidative stress. In the current study, anti-aging potential of a well-known antioxidant, α-lipoic acid (α-LA), in rat embryonic fibroblast (REF) cells was assessed. In this regard, oxidative stress, inflammation, and apoptosis pathways were investigated on REF cells exposed to HO as a senescence inducer and α-LA as a protective compound. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.003DOI Listing
March 2019
1 Read

Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate.

Pharmacol Res 2019 Mar 3;141:224-235. Epub 2019 Jan 3.

Dept. of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy. Electronic address:

Sodium channel myotonia and paramyotonia congenita are caused by gain-of-function mutations in the skeletal muscle voltage-gated sodium channel hNav1.4. The first-line drug is the sodium channel blocker mexiletine; however, some patients show side effects or limited responses. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.004DOI Listing
March 2019
1 Read

Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury.

Pharmacol Res 2019 Mar 3;141:249-263. Epub 2019 Jan 3.

Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States; Department of Medicine, Vascular Biology Center and Cancer Center, Augusta University, Augusta, GA 30912, United States. Electronic address:

Enhanced vascular permeability is associated with inflammation and edema in alveoli during the exudative phase of acute respiratory distress syndrome (ARDS). Mechanisms leading to the endothelial contribution on the early exudative stage of ARDS are not precise. We hypothesized that modulation of endothelial stromelysin1 expression and activity by Akt1-forkhead box-O transcription factors 1/3a (FoxO1/3a) pathway could play a significant role in regulating pulmonary edema during the initial stages of acute lung injury (ALI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183171
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http://dx.doi.org/10.1016/j.phrs.2019.01.006DOI Listing
March 2019
10 Reads

Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis.

Pharmacol Res 2019 Mar 2;141:331-342. Epub 2019 Jan 2.

Department of Pharmacology and Toxicology, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA; Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ, 08901, USA; Department of Environmental and Occupational Health, School of Public Health, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA. Electronic address:

The BCRP/ABCG2 efflux transporter is expressed on the membrane of placental syncytiotrophoblasts and protects the fetus from toxicant exposure. Syncytiotrophoblasts arise from the fusion of cytotrophoblasts, a process negatively regulated by the endocannabinoid, anandamide (AEA). It is unknown whether AEA can influence fetal concentrations of xenobiotics by modulating the expression of transporters in syncytiotrophoblasts. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391190PMC
March 2019
1 Read

Cardenolides: Insights from chemical structure and pharmacological utility.

Pharmacol Res 2019 Mar 21;141:123-175. Epub 2018 Dec 21.

Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University, 55128 Mainz, Germany.

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na/K-ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183118
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http://dx.doi.org/10.1016/j.phrs.2018.12.015DOI Listing
March 2019
14 Reads

Protective effects of curcumin against ischemia-reperfusion injury in the liver.

Pharmacol Res 2019 Mar 15;141:53-62. Epub 2018 Dec 15.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.12.014DOI Listing
March 2019
13 Reads
4.408 Impact Factor

The critical role of microRNAs in stress response: Therapeutic prospect and limitation.

Pharmacol Res 2019 Apr 13;142:294-302. Epub 2018 Dec 13.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address:

Stress response refers to the systemic nonspecific response upon exposure to strong stimulation or chronic stress, such as severe trauma, shock, infection, burn, major surgery or improper environment, which disturb organisms and damage their physical and psychological health. However, the pathogenesis of stress induced disorder remains complicated and diverse under different stress exposure. Recently, studies have revealed a specific role of microRNAs (miRNAs) in regulating cellular function under different types of stress, suggesting a significant role in the treatment and prevention of stress-related diseases, such as stress ulcer, posttraumatic stress disorder, stress-induced cardiomyopathy and so on. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.12.007DOI Listing
April 2019
5 Reads

Targeting STATs in neuroinflammation: The road less traveled!

Pharmacol Res 2019 Mar 11;141:73-84. Epub 2018 Dec 11.

Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

JAK/STAT transduction pathway is a highly conserved pathway implicated in regulating cellular proliferation, differentiation, survival and apoptosis. Dysregulation of this pathway is involved in the onset of autoimmune, haematological, oncological, metabolic and neurological diseases. Over the last few years, the research of anti-neuroinflammatory agents has gained considerable attention. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183057
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http://dx.doi.org/10.1016/j.phrs.2018.12.004DOI Listing
March 2019
28 Reads

Evidence of a PPARγ-mediated mechanism in the ability of Withania somnifera to attenuate tolerance to the antinociceptive effects of morphine.

Pharmacol Res 2019 01 29;139:422-430. Epub 2018 Nov 29.

Dept. of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy.

Notwithstanding the experimental evidence indicating Withania somnifera Dunal roots extract (WSE) ability to prolong morphine-elicited analgesia, the mechanisms underlying this effect are largely unknown. With the aim of evaluating a PPARγ-mediated mechanism in such WSE effects, we verified the ability of the PPARγ antagonist GW-9662 to modulate WSE actions. Further, we evaluated the influence of GW-9662 upon WSE / morphine interaction in SH-SY5Y cells since we previously reported that WSE hampers the morphine-induced μ-opioid receptor (MOP) receptor down-regulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183095
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http://dx.doi.org/10.1016/j.phrs.2018.11.033DOI Listing
January 2019
9 Reads

Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.

Pharmacol Res 2019 01 29;139:431-439. Epub 2018 Nov 29.

College of Pharmacy, Dalian Medical University, 9 Western Lvshun South Road, Dalian 116044, China; The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University, Dalian 116011, China. Electronic address:

Inflammatory reaction and cell apoptosis are two important processes in intestinal ischemia/reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating inflammation and apoptosis is critical important. In this paper, the results indicated that dioscin significantly increased cell viability, and inhibited inflammation and apoptosis caused by hypoxia-reoxygenation (H/R) injury in IEC-6 cells. in vivo II/R injury, dioscin markedly suppressed inflamma- tion and apoptosis, improved pathological changes, and depressed chiu' score in rats. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.040DOI Listing
January 2019
1 Read

Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ.

Pharmacol Res 2019 01 29;139:384-394. Epub 2018 Nov 29.

School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Chinese University of Hong Kong, Hong Kong. Electronic address:

Sirtuin 1 (SIRT1) activation reduces oxidative stress, inhibits inflammatory responses, and retards cellular senescence in endothelial cells in mouse models of diabetes. However, whether SIRT1 also plays a protective role in vascular dysfunction of diabetic and obese mice is not fully characterized. Previous work showed that peroxisome proliferator-activated receptor δ (PPARδ) is beneficial in diabetic vascular dysfunction. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.041DOI Listing
January 2019
6 Reads
4.408 Impact Factor

Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta-analysis.

Pharmacol Res 2019 01 28;139:348-359. Epub 2018 Nov 28.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Cardiovascular disease is a one of most common causes of mortality around the world. This meta-analysis aims to summarize and conclude the clinical evidence regarding the use of saffron and its constituents, in particular crocin, on cardiovascular risk factors. A systematic review was conducted with PubMed, Scopus, Web of Science, Cochrane library and Google Scholar up to 24 May 2018. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.038DOI Listing
January 2019
1 Read

Regulation of microglial process elongation, a featured characteristic of microglial plasticity.

Pharmacol Res 2019 01 23;139:286-297. Epub 2018 Nov 23.

Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu, China. Electronic address:

Microglia, a type of glia within the brain characterized by a ramified morphology, are essential for removing neuronal debris and restricting the expansion of a lesion site. Upon moderate activation, they undergo a transformation in morphology inducing beneficial responses. However, upon strong stimulation, they mediate neuronal damage via production of pro-inflammatory cytokines. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.028DOI Listing
January 2019
22 Reads

Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry.

Pharmacol Res 2019 01 22;139:215-227. Epub 2018 Nov 22.

University of Sydney, School of Pharmacy, Faculty of Medicine and Health, Building (A15) Science Road, Camperdown, NSW, 2006, Australia; Brain and Mind Centre, 94 Mallett Street, Camperdown, NSW, 2050, Australia. Electronic address:

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the α4 and β2 subunits of the nicotinic acetylcholine (nACh) receptor. Pentameric α4β2 nACh receptors are the most abundant nicotinic receptor in the mammalian brain and form two stoichiometries, the (α4)(β2) and (α4)(β2) receptors that differ in their physiological and pharmacological properties. The purpose of this study was to investigate how ADNFLE mutations β2, β2 or α manifest themselves in different receptor stoichiometries. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.031DOI Listing
January 2019
2 Reads

Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation.

Pharmacol Res 2019 01 22;139:325-336. Epub 2018 Nov 22.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea; Department of Biomolecular Science, University of Science & Technology (UST), Daejeon, Republic of Korea. Electronic address:

Adipogenesis involved in hypertrophy and hyperplasia of adipocytes is responsible for expanding the mass of adipose tissues in obese individuals. Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) are two principal transcription factors induced by delicate signaling pathways, including signal transducer and activator of transcription 5 (STAT5), in adipogenesis. Here, we demonstrated a novel role of ginkgetin, a biflavone from Ginkgo biloba leaves, as a STAT5 inhibitor that blocks the differentiation of preadipocytes into adipocytes. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.027DOI Listing
January 2019
5 Reads

Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway.

Pharmacol Res 2019 01 22;139:273-285. Epub 2018 Nov 22.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide. Accumulating evidence suggests that mitochondrial dynamics are closely implicated in carcinogenesis including CRC. Paris Saponin II (PSII), a major steroidal saponin extracted from Rhizoma Paris polyphylla, has emerged as a potential anticancer agent. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.029DOI Listing
January 2019
12 Reads

Beta-amyloid short- and long-term synaptic entanglement.

Pharmacol Res 2019 01 22;139:243-260. Epub 2018 Nov 22.

Department of Drug Sciences, Pharmacology Section, University of Pavia, Italy. Electronic address:

Beta-amyloid (Aβ) is a peptide that derives from the proteolytic cleavage of the amyloid precursor protein (APP) by several secretases. Since its isolation and sequencing from Alzheimer's disease (AD) brains, Aβ has been intensively investigated in the context of AD as the main pathogenic marker responsible for neurodegenerative processes. During the last three decades, results from several independent studies have converged to form the so-called amyloid cascade hypothesis of AD and several therapeutic strategies designed to modulate the APP amyloidogenic pathway have been developed. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.018DOI Listing
January 2019
15 Reads

Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization.

Pharmacol Res 2019 01 20;139:182-190. Epub 2018 Nov 20.

Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy. Electronic address:

The incidence and severity of asthma preponderate in women versus men. Leukotrienes (LTs) are lipid mediators involved in asthma pathogenesis, and sex disparities in LT biosynthesis and anti-LT pharmacology in inflammation have recently emerged. Here, we report on sex dimorphism in LT production during allergen sensitization and its correlation to lung function. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.024DOI Listing
January 2019
12 Reads

Plant-derived medicines for treatment of endometriosis: A comprehensive review of molecular mechanisms.

Pharmacol Res 2019 01 6;139:76-90. Epub 2018 Nov 6.

Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; Evidence-based Evaluation of Cost-Effectiveness and Clinical Outcomes Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Endometriosis is an estrogen-dependent disease with inflammatory lesions at extra-uterine sites, causing pelvic pain and fertility reduction. Conventional therapies primarily focus on reducing systemic levels of estrogens; however, they do not have desirable effectiveness and possess considerable side effects. Therefore, there is a growing interest in the use of herbal medicine for the treatment of endometriosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183118
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http://dx.doi.org/10.1016/j.phrs.2018.11.008DOI Listing
January 2019
22 Reads

Identification of factors associated with first-cycle drug approval rates and regulatory outcomes for new drug applications.

Pharmacol Res 2019 01 5;139:166-172. Epub 2018 Nov 5.

Advanced Academic Programs, Krieger School of Arts and Sciences, Johns Hopkins University, Washington, DC, United States; Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Division of Neurology Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States. Electronic address:

The aims of this study were to identify types of deficiencies resulting in delay of approvals for drugs eventually approved by the US FDA and to search for factors associated with higher first-cycle approval rates. Review documents of New Drug Applications approved between 2008 and 2017 were retrieved from the Drugs@FDA database. Basic characteristics of the applications, regulatory actions, and reasons for non-approvals and/or major amendments after first review cycle were investigated. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.004DOI Listing
January 2019
14 Reads

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential.

Pharmacol Res 2019 01 5;139:62-75. Epub 2018 Nov 5.

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. Electronic address:

Cardiovascular and cerebrovascular diseases are the main cause of mortality worldwide, currently with less than optimum therapeutic options. Danhong injection (DHI) is a medicinal preparation based on two eminent Chinese herbal medicines, Salviae Miltiorrhizae (Dan Shen; family: Lamiaceae) and Flos Carthami (Hong Hua; family: Compositae/Asteraceae). DHI has been mainly used in the clinical therapy of cardiovascular (such as acute coronary syndrome and angina pectoris) and cerebrovascular diseases (such as stroke) in China for many years. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.006DOI Listing
January 2019
10 Reads

Etrolizumab versus infliximab in the treatment of induction phase of ulcerative colitis: A systematic review and indirect comparison.

Pharmacol Res 2019 01 3;139:120-125. Epub 2018 Nov 3.

Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Objectives: There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis.

Methods: This meta-analysis was performed according to the PRISMA statement protocol. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.003DOI Listing
January 2019
7 Reads

3D organ models-Revolution in pharmacological research?

Pharmacol Res 2019 01 3;139:446-451. Epub 2018 Nov 3.

Freie Universität Berlin, Institute for Pharmacy, Pharmacology & Toxicology, Königin-Luise-Str. 2-4, Berlin, 14195, Germany. Electronic address:

3D organ models have gained increasing attention as novel preclinical test systems and alternatives to animal testing. Over the years, many excellent in vitro tissue models have been developed. In parallel, microfluidic organ-on-a-chip tissue cultures have gained increasing interest for their ability to house several organ models on a single device and interlink these within a human-like environment. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.002DOI Listing
January 2019
10 Reads

Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents.

Pharmacol Res 2019 01 3;139:126-140. Epub 2018 Nov 3.

TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address:

Except for an essential step for the pathology of multiple diseases including atherosclerosis and rheumatoid arthritis, inflammation is an imperative therapeutic target for developing novel approaches for pharmacological interventions. Thus, molecular understanding of inflammation not only revealed the mechanisms of drug action and their biological targets but also has spawned innovative maneuvers to influence multifaceted biological systems, providing new prospects for drug designing and suggesting important new implications for existing clinical medicine. Meanwhile, modulation of inflammation with the use of medicinal plants proposed an alternate to conventional therapeutic strategies for numerous ailments, particularly when suppression of inflammation is expected. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.001DOI Listing
January 2019
18 Reads
4.410 Impact Factor

Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.

Pharmacol Res 2019 01 1;139:41-49. Epub 2018 Nov 1.

Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Biomedical and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. Electronic address:

Irinotecan (CPT-11), a first-line chemotherapy for advanced colorectal cancer, causes serious diarrhea in patients receiving treatment. The underlying mechanism has been shown that the active metabolite of CPT-11, SN-38, is metabolized to the inactive metabolite SN-38 glucuronide (SN-38 G) during hepatic glucuronidation, and subsequently is exported into the intestine, where SN-38 G is hydrolyzed by bacterial β-glucuronidase (βG) to be SN-38, thus leading to intestinal toxicity. Thus, inhibition of the intestinal bacterial βG activity is expected to prevent CPT-11-induced diarrhea. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.10.029DOI Listing
January 2019
4 Reads

T cell toxicity of HIV latency reversing agents.

Pharmacol Res 2019 01 23;139:524-534. Epub 2018 Oct 23.

Department of Immunology, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address:

Combination antiretroviral therapy reduces morbidity and mortality in HIV infected patients. However, the cure of HIV infection is hindered by the persistence of the latent HIV reservoir. Latency reversing agents (LRAs) are developed to target the HIV latently infected cells for HIV reactivation. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.10.023DOI Listing
January 2019
20 Reads

Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections.

Pharmacol Res 2018 11 10;137:259-269. Epub 2018 Oct 10.

College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China. Electronic address:

Currently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease, stroke and osteoporosis are increasing fast and fast. It's critical necessary to discovery lead compounds for new drug development. Dioscin, one active compound in some medicinal plants, has anti-inflammation, immunoregulation, hypolipidemic, anti-viral, anti-fungal and anti-allergic effects. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.09.022DOI Listing
November 2018
6 Reads

Effects of curcumin on hypoxia-inducible factor as a new therapeutic target.

Pharmacol Res 2018 11 10;137:159-169. Epub 2018 Oct 10.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that consists of two subunits, the HIF-1α and HIF-1β (ARNT). Under hypoxic conditions, HIF-1 is an adaptive system that regulates the transcription of multiple genes associated with growth, angiogenesis, proliferation, glucose transport, metabolism, pH regulation and cell death. However, aberrant HIF-1 activation contributes to the pathophysiology of several human diseases such as cancer, ischemic cardiovascular disorders, and pulmonary and kidney diseases. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.10.009DOI Listing
November 2018
2 Reads

The effect of statin therapy on endoplasmic reticulum stress.

Pharmacol Res 2018 11 9;137:150-158. Epub 2018 Oct 9.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

The endoplasmic reticulum (ER) is critical in protein processing and particularly in ensuring that proteins undergo their correct folding to exert their functionality. What is becoming increasingly clear is that the ER may undergo increasing stress brought about by nutrient deprivation, hypoxia, oxidized lipids, point mutations in secreted proteins, cellular differentiation or significant deviation from metabolic set points, and loss of Ca homeostasis, with detrimental effects on ER-resident calcium-dependent chaperones, alone or in combination. This results in the unfolded protein response (UPR) that is a repair mechanism to limit the formation of newly damaged proteins until ER homeostasis is restored, though may result in increased cell death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183149
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http://dx.doi.org/10.1016/j.phrs.2018.10.006DOI Listing
November 2018
21 Reads