609 results match your criteria Journal of Pharmacy and Pharmacological Research [Journal]


The therapeutic role of long non-coding RNAs in human diseases: A focus on the recent insights into autophagy.

Pharmacol Res 2019 Feb 8;142:22-29. Epub 2019 Feb 8.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Centre, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Long non-coding RNA (lncRNA) is a class of non-coding RNA with ≥200 nucleotides in length which are involved as critical regulators in various cellular processes. LncRNAs contribute to the development and progression of many human diseases. Autophagy is a key catabolic process which helps to maintain the cellular homeostasis through the decay of damaged or unwanted proteins and dysfunctional cytoplasmic organelles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618193017
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http://dx.doi.org/10.1016/j.phrs.2019.02.010DOI Listing
February 2019
1 Read

Neuropharmacology, pharmacogenetics and pharmacogenomics of aggression: The zebrafish model.

Pharmacol Res 2019 Jan 29;141:602-608. Epub 2019 Jan 29.

School of Pharmacy, Southwest University, Chongqing, China; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Ural Federal University, Ekaterinburg, Russia; Granov's Russian Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia; Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia. Electronic address:

The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in neurobehavioral research. Aggression is a common symptom of many CNS disorders, has some genetic determinants and can be modulated pharmacologically in humans and animal model species. Mounting evidence suggests zebrafish as a useful tool to study neurobiology of aggression, and its pharmacological and genetic regulation. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.044DOI Listing
January 2019
1 Read

Diabetic nephropathy: The regulatory interplay between epigenetics and microRNAs.

Pharmacol Res 2019 Jan 26;141:574-585. Epub 2019 Jan 26.

Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India. Electronic address:

Diabetic nephropathy (DN) is still one of the leading causes of end-stage renal disease despite the emergence of different therapies to counter the metabolic, hemodynamic and fibrotic pathways, implicating a prominent role of genetic and epigenetic factors in its progression. Epigenetics is the study of changes in the expression of genes which may be inheritable and does not involve a change in the genome sequence. Thrust areas of epigenetic research are DNA methylation and histone modifications. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.043DOI Listing
January 2019
3 Reads

Current evidence and future perspectives for curcumin and its analogues as promising adjuncts to oxaliplatin: state-of-the-art.

Pharmacol Res 2019 Jan 11;141:343-356. Epub 2019 Jan 11.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Curcumin is a multifunctional phytochemical that has documented anti-oxidant, anti-inflammatory and anti-tumor properties. The anti-tumor effect of curcumin has been widely investigated, both as a single ingredient and in combination with chemotherapeutic agents. Oxaliplatin is a third-generation platinum agent with established effectiveness in multiple malignancies including gastroesophageal, colorectal, pancreas, ovarian, breast and head and neck cancers. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.020DOI Listing
January 2019
5 Reads

Rev-erbα activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice.

Pharmacol Res 2019 Jan 11;141:310-318. Epub 2019 Jan 11.

Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, Guangzhou, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, China. Electronic address:

REV-ERBα (NR1D1) is a nuclear heme receptor that controls many cellular processes including cell differentiation, lipid metabolism, and inflammatory responses. Although REV-ERBα has been also implicated in regulation of glucose homeostasis, the mechanism for this regulation remains unclear. Here we investigate a potential role of REV-ERBα in regulation of PCK1 (phosphoenolpyruvate carboxykinase 1), a rate-limiting enzyme in gluconeogenesis. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.010DOI Listing
January 2019
1 Read

Targeting Hedgehog signaling pathway: Paving the road for cancer therapy.

Pharmacol Res 2019 Jan 11;141:466-480. Epub 2019 Jan 11.

Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The Hedgehog pathway is essential for embryonic development but also for tissue and organ homeostasis in adult organisms. Activation of this pathway leads to the expression of target genes involved in proliferation, angiogenesis and stem cell self-renewal. Moreover, abnormal persistence of Hedgehog signaling is directly involved in a wide range of human cancers. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.014DOI Listing
January 2019
4 Reads
4.408 Impact Factor

A novel nanoformulation of PLGA with high non-ionic surfactant content improves in vitro and in vivo PTX activity against lung cancer.

Pharmacol Res 2019 Jan 8;141:451-465. Epub 2019 Jan 8.

Institute of Biopathology and Regenerative Medicine (IBIM9090325ER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain; Department of Anatomy and Embriology, Faculty of Medicine, University of Granada, 18071 Granada, Spain; Biosanitary Institute of Granada (ibs.GRANADA), SAS-University of Granada, 18014 Granada, Spain.

Paclitaxel (PTX), a chemotherapy agent widely used to treat lung cancer, is characterised by high toxicity, low bioavailability and the need to use of excipients with serious side effects that limit its use. Paclitaxel encapsulation into nanoparticles (NPs) generates drug pharmacokinetic and pharmacodynamic advantages compared to free PTX. In this context, a NP carrier formed from a copolymer of lactic acid and glycolic acid (PLGA) has demonstrated high biocompatibility and low toxicity and therefore being approved by FDA to be used in humans. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.013DOI Listing
January 2019

Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids.

Pharmacol Res 2019 Jan 4;141:291-297. Epub 2019 Jan 4.

Curtin Health Innovation Research Institute, Curtin University, WA, Australia; School of Public Health, Faculty of Health Sciences, Curtin University, WA, Australia. Electronic address:

Type-2 diabetes (T2D) increases the risk of dementia by ˜5-fold, however the mechanisms by which T2D increases dementia risk remain unclear. Evidence suggests that the heightened inflammation and oxidative stress in T2D may lead to disruption of the blood-brain barrier (BBB), which precedes premature cognitive decline. Studies show that vascular-targeted anti-inflammatory treatments protect the BBB by attenuating neuroinflammation, and in some studies attenuate cognitive decline. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.009DOI Listing
January 2019
2 Reads
4.408 Impact Factor

α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress.

Pharmacol Res 2019 Jan 3;141:214-223. Epub 2019 Jan 3.

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Senescence is a process characterized by an irreversible growth arrest in cells and induced by oxidative stress. In the current study, anti-aging potential of a well-known antioxidant, α-lipoic acid (α-LA), in rat embryonic fibroblast (REF) cells was assessed. In this regard, oxidative stress, inflammation, and apoptosis pathways were investigated on REF cells exposed to HO as a senescence inducer and α-LA as a protective compound. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.003DOI Listing
January 2019

Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate.

Pharmacol Res 2019 Jan 3;141:224-235. Epub 2019 Jan 3.

Dept. of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy. Electronic address:

Sodium channel myotonia and paramyotonia congenita are caused by gain-of-function mutations in the skeletal muscle voltage-gated sodium channel hNav1.4. The first-line drug is the sodium channel blocker mexiletine; however, some patients show side effects or limited responses. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.004DOI Listing
January 2019

Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury.

Pharmacol Res 2019 Jan 3;141:249-263. Epub 2019 Jan 3.

Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States; Department of Medicine, Vascular Biology Center and Cancer Center, Augusta University, Augusta, GA 30912, United States. Electronic address:

Enhanced vascular permeability is associated with inflammation and edema in alveoli during the exudative phase of acute respiratory distress syndrome (ARDS). Mechanisms leading to the endothelial contribution on the early exudative stage of ARDS are not precise. We hypothesized that modulation of endothelial stromelysin1 expression and activity by Akt1-forkhead box-O transcription factors 1/3a (FoxO1/3a) pathway could play a significant role in regulating pulmonary edema during the initial stages of acute lung injury (ALI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183171
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http://dx.doi.org/10.1016/j.phrs.2019.01.006DOI Listing
January 2019
4 Reads

Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis.

Pharmacol Res 2019 Jan 2;141:331-342. Epub 2019 Jan 2.

Department of Pharmacology and Toxicology, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA; Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ, 08901, USA; Department of Environmental and Occupational Health, School of Public Health, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA. Electronic address:

The BCRP/ABCG2 efflux transporter is expressed on the membrane of placental syncytiotrophoblasts and protects the fetus from toxicant exposure. Syncytiotrophoblasts arise from the fusion of cytotrophoblasts, a process negatively regulated by the endocannabinoid, anandamide (AEA). It is unknown whether AEA can influence fetal concentrations of xenobiotics by modulating the expression of transporters in syncytiotrophoblasts. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.002DOI Listing
January 2019

Cardenolides: Insights from chemical structure and pharmacological utility.

Pharmacol Res 2018 Dec 21;141:123-175. Epub 2018 Dec 21.

Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University, 55128 Mainz, Germany.

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na/K-ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183118
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http://dx.doi.org/10.1016/j.phrs.2018.12.015DOI Listing
December 2018
9 Reads

Protective effects of curcumin against ischemia-reperfusion injury in the liver.

Pharmacol Res 2018 Dec 15;141:53-62. Epub 2018 Dec 15.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.12.014DOI Listing
December 2018
8 Reads
4.408 Impact Factor

The critical role of microRNAs in stress response: therapeutic prospect and limitation.

Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address:

Stress response refers to the systemic nonspecific response upon exposure to strong stimulation or chronic stress, such as severe trauma, shock, infection, burn, major surgery or improper environment, which disturb organisms and damage their physical and psychological health. However, the pathogenesis of stress induced disorder remains complicated and diverse under different stress exposure. Recently, studies have revealed a specific role of microRNAs (miRNAs) in regulating cellular function under different types of stress, suggesting a significant role in the treatment and prevention of stress-related diseases, such as stress ulcer, posttraumatic stress disorder, stress-induced cardiomyopathy and so on. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.12.007DOI Listing
December 2018
4 Reads

Targeting STATs in neuroinflammation: The road less traveled!

Pharmacol Res 2018 Dec 11;141:73-84. Epub 2018 Dec 11.

Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

JAK/STAT transduction pathway is a highly conserved pathway implicated in regulating cellular proliferation, differentiation, survival and apoptosis. Dysregulation of this pathway is involved in the onset of autoimmune, haematological, oncological, metabolic and neurological diseases. Over the last few years, the research of anti-neuroinflammatory agents has gained considerable attention. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.12.004DOI Listing
December 2018
13 Reads

Evidence of a PPARγ-mediated mechanism in the ability of Withania somnifera to attenuate tolerance to the antinociceptive effects of morphine.

Pharmacol Res 2019 Jan 29;139:422-430. Epub 2018 Nov 29.

Dept. of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy.

Notwithstanding the experimental evidence indicating Withania somnifera Dunal roots extract (WSE) ability to prolong morphine-elicited analgesia, the mechanisms underlying this effect are largely unknown. With the aim of evaluating a PPARγ-mediated mechanism in such WSE effects, we verified the ability of the PPARγ antagonist GW-9662 to modulate WSE actions. Further, we evaluated the influence of GW-9662 upon WSE / morphine interaction in SH-SY5Y cells since we previously reported that WSE hampers the morphine-induced μ-opioid receptor (MOP) receptor down-regulation. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.033DOI Listing
January 2019
8 Reads

Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.

Pharmacol Res 2019 Jan 29;139:431-439. Epub 2018 Nov 29.

College of Pharmacy, Dalian Medical University, 9 Western Lvshun South Road, Dalian 116044, China; The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University, Dalian 116011, China. Electronic address:

Inflammatory reaction and cell apoptosis are two important processes in intestinal ischemia/reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating inflammation and apoptosis is critical important. In this paper, the results indicated that dioscin significantly increased cell viability, and inhibited inflammation and apoptosis caused by hypoxia-reoxygenation (H/R) injury in IEC-6 cells. in vivo II/R injury, dioscin markedly suppressed inflamma- tion and apoptosis, improved pathological changes, and depressed chiu' score in rats. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.040DOI Listing
January 2019

Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ.

Pharmacol Res 2019 Jan 29;139:384-394. Epub 2018 Nov 29.

School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Chinese University of Hong Kong, Hong Kong. Electronic address:

Sirtuin 1 (SIRT1) activation reduces oxidative stress, inhibits inflammatory responses, and retards cellular senescence in endothelial cells in mouse models of diabetes. However, whether SIRT1 also plays a protective role in vascular dysfunction of diabetic and obese mice is not fully characterized. Previous work showed that peroxisome proliferator-activated receptor δ (PPARδ) is beneficial in diabetic vascular dysfunction. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.041DOI Listing
January 2019
2 Reads
4.408 Impact Factor

Clinical evidence on the effects of saffron (Crocus sativus L.) on cardiovascular risk factors: A systematic review meta-analysis.

Pharmacol Res 2019 Jan 28;139:348-359. Epub 2018 Nov 28.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Cardiovascular disease is a one of most common causes of mortality around the world. This meta-analysis aims to summarize and conclude the clinical evidence regarding the use of saffron and its constituents, in particular crocin, on cardiovascular risk factors. A systematic review was conducted with PubMed, Scopus, Web of Science, Cochrane library and Google Scholar up to 24 May 2018. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.038DOI Listing
January 2019

Regulation of microglial process elongation, a featured characteristic of microglial plasticity.

Pharmacol Res 2019 Jan 23;139:286-297. Epub 2018 Nov 23.

Department of Pharmacology, School of Pharmacy, Nantong University, #19 Qixiu Road, Nantong 226001, Jiangsu, China. Electronic address:

Microglia, a type of glia within the brain characterized by a ramified morphology, are essential for removing neuronal debris and restricting the expansion of a lesion site. Upon moderate activation, they undergo a transformation in morphology inducing beneficial responses. However, upon strong stimulation, they mediate neuronal damage via production of pro-inflammatory cytokines. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.028DOI Listing
January 2019
15 Reads

Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry.

Pharmacol Res 2019 Jan 22;139:215-227. Epub 2018 Nov 22.

University of Sydney, School of Pharmacy, Faculty of Medicine and Health, Building (A15) Science Road, Camperdown, NSW, 2006, Australia; Brain and Mind Centre, 94 Mallett Street, Camperdown, NSW, 2050, Australia. Electronic address:

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the α4 and β2 subunits of the nicotinic acetylcholine (nACh) receptor. Pentameric α4β2 nACh receptors are the most abundant nicotinic receptor in the mammalian brain and form two stoichiometries, the (α4)(β2) and (α4)(β2) receptors that differ in their physiological and pharmacological properties. The purpose of this study was to investigate how ADNFLE mutations β2, β2 or α manifest themselves in different receptor stoichiometries. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.031DOI Listing
January 2019

Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation.

Pharmacol Res 2019 Jan 22;139:325-336. Epub 2018 Nov 22.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea; Department of Biomolecular Science, University of Science & Technology (UST), Daejeon, Republic of Korea. Electronic address:

Adipogenesis involved in hypertrophy and hyperplasia of adipocytes is responsible for expanding the mass of adipose tissues in obese individuals. Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) are two principal transcription factors induced by delicate signaling pathways, including signal transducer and activator of transcription 5 (STAT5), in adipogenesis. Here, we demonstrated a novel role of ginkgetin, a biflavone from Ginkgo biloba leaves, as a STAT5 inhibitor that blocks the differentiation of preadipocytes into adipocytes. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.027DOI Listing
January 2019
2 Reads

Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway.

Pharmacol Res 2019 Jan 22;139:273-285. Epub 2018 Nov 22.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide. Accumulating evidence suggests that mitochondrial dynamics are closely implicated in carcinogenesis including CRC. Paris Saponin II (PSII), a major steroidal saponin extracted from Rhizoma Paris polyphylla, has emerged as a potential anticancer agent. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.029DOI Listing
January 2019
7 Reads

Beta-amyloid short- and long-term synaptic entanglement.

Pharmacol Res 2019 Jan 22;139:243-260. Epub 2018 Nov 22.

Department of Drug Sciences, Pharmacology Section, University of Pavia, Italy. Electronic address:

Beta-amyloid (Aβ) is a peptide that derives from the proteolytic cleavage of the amyloid precursor protein (APP) by several secretases. Since its isolation and sequencing from Alzheimer's disease (AD) brains, Aβ has been intensively investigated in the context of AD as the main pathogenic marker responsible for neurodegenerative processes. During the last three decades, results from several independent studies have converged to form the so-called amyloid cascade hypothesis of AD and several therapeutic strategies designed to modulate the APP amyloidogenic pathway have been developed. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.018DOI Listing
January 2019
8 Reads

Leukotriene-mediated sex dimorphism in murine asthma-like features during allergen sensitization.

Pharmacol Res 2019 Jan 20;139:182-190. Epub 2018 Nov 20.

Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, I-80131 Naples, Italy. Electronic address:

The incidence and severity of asthma preponderate in women versus men. Leukotrienes (LTs) are lipid mediators involved in asthma pathogenesis, and sex disparities in LT biosynthesis and anti-LT pharmacology in inflammation have recently emerged. Here, we report on sex dimorphism in LT production during allergen sensitization and its correlation to lung function. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.024DOI Listing
January 2019
7 Reads

Plant-derived medicines for treatment of endometriosis: A comprehensive review of molecular mechanisms.

Pharmacol Res 2019 Jan 6;139:76-90. Epub 2018 Nov 6.

Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; Evidence-based Evaluation of Cost-Effectiveness and Clinical Outcomes Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Endometriosis is an estrogen-dependent disease with inflammatory lesions at extra-uterine sites, causing pelvic pain and fertility reduction. Conventional therapies primarily focus on reducing systemic levels of estrogens; however, they do not have desirable effectiveness and possess considerable side effects. Therefore, there is a growing interest in the use of herbal medicine for the treatment of endometriosis. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.008DOI Listing
January 2019
14 Reads

Identification of factors associated with first-cycle drug approval rates and regulatory outcomes for new drug applications.

Pharmacol Res 2019 Jan 5;139:166-172. Epub 2018 Nov 5.

Advanced Academic Programs, Krieger School of Arts and Sciences, Johns Hopkins University, Washington, DC, United States; Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Division of Neurology Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States. Electronic address:

The aims of this study were to identify types of deficiencies resulting in delay of approvals for drugs eventually approved by the US FDA and to search for factors associated with higher first-cycle approval rates. Review documents of New Drug Applications approved between 2008 and 2017 were retrieved from the Drugs@FDA database. Basic characteristics of the applications, regulatory actions, and reasons for non-approvals and/or major amendments after first review cycle were investigated. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.004DOI Listing
January 2019
9 Reads

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential.

Pharmacol Res 2019 Jan 5;139:62-75. Epub 2018 Nov 5.

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. Electronic address:

Cardiovascular and cerebrovascular diseases are the main cause of mortality worldwide, currently with less than optimum therapeutic options. Danhong injection (DHI) is a medicinal preparation based on two eminent Chinese herbal medicines, Salviae Miltiorrhizae (Dan Shen; family: Lamiaceae) and Flos Carthami (Hong Hua; family: Compositae/Asteraceae). DHI has been mainly used in the clinical therapy of cardiovascular (such as acute coronary syndrome and angina pectoris) and cerebrovascular diseases (such as stroke) in China for many years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183085
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http://dx.doi.org/10.1016/j.phrs.2018.11.006DOI Listing
January 2019
4 Reads

Etrolizumab versus infliximab in the treatment of induction phase of ulcerative colitis: A systematic review and indirect comparison.

Pharmacol Res 2019 Jan 3;139:120-125. Epub 2018 Nov 3.

Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Objectives: There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis.

Methods: This meta-analysis was performed according to the PRISMA statement protocol. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183114
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http://dx.doi.org/10.1016/j.phrs.2018.11.003DOI Listing
January 2019
6 Reads

3D organ models-Revolution in pharmacological research?

Pharmacol Res 2019 Jan 3;139:446-451. Epub 2018 Nov 3.

Freie Universität Berlin, Institute for Pharmacy, Pharmacology & Toxicology, Königin-Luise-Str. 2-4, Berlin, 14195, Germany. Electronic address:

3D organ models have gained increasing attention as novel preclinical test systems and alternatives to animal testing. Over the years, many excellent in vitro tissue models have been developed. In parallel, microfluidic organ-on-a-chip tissue cultures have gained increasing interest for their ability to house several organ models on a single device and interlink these within a human-like environment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183135
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http://dx.doi.org/10.1016/j.phrs.2018.11.002DOI Listing
January 2019
6 Reads

Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents.

Pharmacol Res 2019 Jan 3;139:126-140. Epub 2018 Nov 3.

TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China. Electronic address:

Except for an essential step for the pathology of multiple diseases including atherosclerosis and rheumatoid arthritis, inflammation is an imperative therapeutic target for developing novel approaches for pharmacological interventions. Thus, molecular understanding of inflammation not only revealed the mechanisms of drug action and their biological targets but also has spawned innovative maneuvers to influence multifaceted biological systems, providing new prospects for drug designing and suggesting important new implications for existing clinical medicine. Meanwhile, modulation of inflammation with the use of medicinal plants proposed an alternate to conventional therapeutic strategies for numerous ailments, particularly when suppression of inflammation is expected. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.11.001DOI Listing
January 2019
13 Reads
4.410 Impact Factor

Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.

Pharmacol Res 2019 Jan 1;139:41-49. Epub 2018 Nov 1.

Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Biomedical and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. Electronic address:

Irinotecan (CPT-11), a first-line chemotherapy for advanced colorectal cancer, causes serious diarrhea in patients receiving treatment. The underlying mechanism has been shown that the active metabolite of CPT-11, SN-38, is metabolized to the inactive metabolite SN-38 glucuronide (SN-38 G) during hepatic glucuronidation, and subsequently is exported into the intestine, where SN-38 G is hydrolyzed by bacterial β-glucuronidase (βG) to be SN-38, thus leading to intestinal toxicity. Thus, inhibition of the intestinal bacterial βG activity is expected to prevent CPT-11-induced diarrhea. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.10.029DOI Listing
January 2019

T cell toxicity of HIV latency reversing agents.

Pharmacol Res 2019 Jan 23;139:524-534. Epub 2018 Oct 23.

Department of Immunology, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address:

Combination antiretroviral therapy reduces morbidity and mortality in HIV infected patients. However, the cure of HIV infection is hindered by the persistence of the latent HIV reservoir. Latency reversing agents (LRAs) are developed to target the HIV latently infected cells for HIV reactivation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183097
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http://dx.doi.org/10.1016/j.phrs.2018.10.023DOI Listing
January 2019
13 Reads

Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections.

Pharmacol Res 2018 Nov 10;137:259-269. Epub 2018 Oct 10.

College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China. Electronic address:

Currently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease, stroke and osteoporosis are increasing fast and fast. It's critical necessary to discovery lead compounds for new drug development. Dioscin, one active compound in some medicinal plants, has anti-inflammation, immunoregulation, hypolipidemic, anti-viral, anti-fungal and anti-allergic effects. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.09.022DOI Listing
November 2018
5 Reads

Effects of curcumin on hypoxia-inducible factor as a new therapeutic target.

Pharmacol Res 2018 Nov 10;137:159-169. Epub 2018 Oct 10.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that consists of two subunits, the HIF-1α and HIF-1β (ARNT). Under hypoxic conditions, HIF-1 is an adaptive system that regulates the transcription of multiple genes associated with growth, angiogenesis, proliferation, glucose transport, metabolism, pH regulation and cell death. However, aberrant HIF-1 activation contributes to the pathophysiology of several human diseases such as cancer, ischemic cardiovascular disorders, and pulmonary and kidney diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183150
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http://dx.doi.org/10.1016/j.phrs.2018.10.009DOI Listing
November 2018
1 Read

The effect of statin therapy on endoplasmic reticulum stress.

Pharmacol Res 2018 Nov 9;137:150-158. Epub 2018 Oct 9.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

The endoplasmic reticulum (ER) is critical in protein processing and particularly in ensuring that proteins undergo their correct folding to exert their functionality. What is becoming increasingly clear is that the ER may undergo increasing stress brought about by nutrient deprivation, hypoxia, oxidized lipids, point mutations in secreted proteins, cellular differentiation or significant deviation from metabolic set points, and loss of Ca homeostasis, with detrimental effects on ER-resident calcium-dependent chaperones, alone or in combination. This results in the unfolded protein response (UPR) that is a repair mechanism to limit the formation of newly damaged proteins until ER homeostasis is restored, though may result in increased cell death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183149
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http://dx.doi.org/10.1016/j.phrs.2018.10.006DOI Listing
November 2018
11 Reads

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability.

Pharmacol Res 2018 Nov 22;137:47-55. Epub 2018 Sep 22.

The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

Brigatinib is an FDA-approved oral anaplastic lymphoma kinase (ALK) inhibitor for treatment of metastatic non-small cell lung cancer (NSCLC). Using genetically modified mouse models, we investigated the roles of the multidrug efflux transporters ABCB1 and ABCG2, and the multispecific drug-metabolizing enzyme CYP3 A in plasma pharmacokinetics and tissue distribution of brigatinib. In vitro, brigatinib was exceptionally well transported by human ABCB1 and mouse Abcg2, and efficiently by human ABCG2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183098
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http://dx.doi.org/10.1016/j.phrs.2018.09.020DOI Listing
November 2018
1 Read

Protective effect of dioscin against intestinal ischemia/reperfusion injury via adjusting miR-351-5p-mediated oxidative stress.

Pharmacol Res 2018 Nov 18;137:56-63. Epub 2018 Sep 18.

College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China. Electronic address:

Oxidative stress plays important roles in intestinal ischemia-reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating oxidative stress is necessary. In this study, the effects and possible mechanisms of dioscin against hypoxia-reoxygenation (H/R) injury in IEC-6 cells and II/R injury in mice were investigated. The results showed that dioscin markedly increased cell viability, and reduced ROS level caused by H/R injury in IEC-6 cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183104
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http://dx.doi.org/10.1016/j.phrs.2018.09.016DOI Listing
November 2018
2 Reads

Preventing childhood and lifelong disability: Maternal dietary supplementation for perinatal brain injury.

Pharmacol Res 2019 Jan 15;139:228-242. Epub 2018 Sep 15.

Departments of Pediatrics, Pediatric Neurosciences, Neuroscience and Mental Health Institute, Integrative Health Institute, Faculty of Medicine & Dentistry, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

The majority of brain injuries that lead to cerebral palsy, developmental disability, and mental health disorders have their onset in utero. These lifelong conditions come with great economic and emotional burden as they impact function in nearly all domains of affected individuals' lives. Unfortunately, current therapeutic options are limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183039
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http://dx.doi.org/10.1016/j.phrs.2018.08.022DOI Listing
January 2019
24 Reads

Therapeutic potential of curcumin in diabetic complications.

Pharmacol Res 2018 Oct 13;136:181-193. Epub 2018 Sep 13.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Diabetes mellitus is an extremely prevalent endocrine disease and a major global public health concern. Diabetic complications, such as retinopathy, nephropathy, neuropathy and cardiovascular disease, are common and majorly impact a patient's quality of life. Curcumin, the major active component of turmeric, possesses extensive known pharmacological properties, including anti-inflammatory, antioxidant, and antitumor effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183077
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http://dx.doi.org/10.1016/j.phrs.2018.09.012DOI Listing
October 2018
6 Reads

Circulating tumor DNA - Current state of play and future perspectives.

Pharmacol Res 2018 Oct 22;136:35-44. Epub 2018 Aug 22.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney Australia, PO Box 123, Broadway, NSW, 2007, Australia. Electronic address:

Cancer management paradigms are shifting towards a personalized approach thanks to the advent of the -omics technologies. Liquid biopsies, consisting in the sampling of blood and other bodily fluids, are emerging as a valid alternative to circulating tumor biomarkers and tumor tissue biopsies for cancer diagnosis, routine monitoring and prognostication. The content of a liquid biopsy is referred to as the "tumor circulome". Read More

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http://dx.doi.org/10.1016/j.phrs.2018.08.017DOI Listing
October 2018
20 Reads

A PK/PD study of Delta-4 abiraterone metabolite in metastatic castration-resistant prostate cancer patients.

Pharmacol Res 2018 Oct 22;136:56-61. Epub 2018 Aug 22.

Department of Medical Oncology, Hôpital Cochin, AP-HP, Paris, France; University of Paris Descartes, CARPEM, Paris, France; Cochin Institute, INSERM U1016, Paris, France. Electronic address:

Δ-abiraterone (Δ4A) is an activemetabolite of abiraterone (ABI), which is approved in the treatment of metastatic castration resistant prostate cancer (mCRPC). The contribution of Δ4A to the clinical antitumor activity of ABI remains unknown. The aim of this study was to explore the relationship between plasma Δ4A concentration and survival in 36 mCRPC patients treated with abiraterone acetate (1000 mg/day) plus prednisone (10 mg/day). Read More

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http://dx.doi.org/10.1016/j.phrs.2018.08.016DOI Listing
October 2018
7 Reads

Astaxanthin: A mechanistic review on its biological activities and health benefits.

Pharmacol Res 2018 Oct 17;136:1-20. Epub 2018 Aug 17.

Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Astaxanthin (AST) is a potent lipid-soluble keto-carotenoid with auspicious effects on human health. It protects organisms against a wide range of diseases with excellent safety and tolerability. Various imperative biological activities in vitro and in vivo models have been suggested for AST. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.08.012DOI Listing
October 2018
14 Reads
4.410 Impact Factor

Effect of statins on toll-like receptors: a new insight to pleiotropic effects.

Pharmacol Res 2018 Sep 16;135:230-238. Epub 2018 Aug 16.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

The toll-like receptors (TLRs) are a class of transmembrane-spanning receptors that are sentinels of both innate and adaptive immunity. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. However, statin therapy appears to have pleiotropic effects including attenuation of chronic low-grade inflammation and modulation of TLR activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183117
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http://dx.doi.org/10.1016/j.phrs.2018.08.014DOI Listing
September 2018
15 Reads

CHST3 and CHST13 polymorphisms as predictors of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension.

Pharmacol Res 2018 Sep 15;135:259-264. Epub 2018 Aug 15.

Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada, Kobe 658-8558, Japan; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe 650-0017, Japan. Electronic address:

Bosentan, an endothelin receptor antagonist, has been widely used as a first-line drug for the treatment of pulmonary arterial hypertension (PAH). In addition, bosentan is approved for patients with digital ulcers related to systemic sclerosis. Liver dysfunction is a major adverse effect of bosentan and may lead to discontinuation of therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183041
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http://dx.doi.org/10.1016/j.phrs.2018.08.011DOI Listing
September 2018
10 Reads

ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma cells via regulating transcription factor activity of PXR.

Pharmacol Res 2018 Sep 13;135:188-200. Epub 2018 Aug 13.

School of Foreign Languages, Shaanxi Normal University, Xi'an, 710062, PR China. Electronic address:

Transcription factor E26 transformation specific sequence 1 (ETS-1) is a primary regulator in the metastasis of human cancer cells, especially hepatocellular carcinoma (HCC) cells; and it would affect the prognosis of HCC patients who received chemotherapies. However, the regulatory role of ETS-1 in the resistance of HCC cells to molecular-targeting agent remains poorly understood. In the present work, we demonstrate that high ETS-1 expression correlates with poor prognosis of advanced HCC patients received Sorafenib treatment. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.08.003DOI Listing
September 2018
1 Read

Targeting molecular pathways in cancer stem cells by natural bioactive compounds.

Pharmacol Res 2018 Sep 10;135:150-165. Epub 2018 Aug 10.

Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche, Ancona, 60131, Ancona, Italy. Electronic address:

Cancer Stem Cells (CSCs) or Tumor-Initiating Cells (TICs) are a small sub-population of cells within the tumor, able to give chemio- and radio-resistance and cause the onset of metastasis and the presence of relapses; for these reasons, they are recently becoming a potential target for anticancer therapy. One of the main characteristics of these cells is the self-renewal through the capability of modulating different molecular signalling pathways, including Wnt/β-Catenin, Sonic Hedgehog and Notch pathways. Natural bioactive compounds such as resveratrol, epigallocatechin, curcumin, quercetin, ellagic acid, anthocyanins and other compounds and extracts can have a direct or indirect effect on these molecular pathways, decreasing the pathological activities of CSCs. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.08.006DOI Listing
September 2018
2 Reads

Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3.

Pharmacol Res 2018 Sep 10;135:166-180. Epub 2018 Aug 10.

Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, Jilin Province, China. Electronic address:

Dictamnus dasycarpus is a traditional Chinese medicine thathas been commonly used in the treatment of cancer. Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183066
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http://dx.doi.org/10.1016/j.phrs.2018.08.004DOI Listing
September 2018
23 Reads

Effect of ursodeoxycholic acid on glycemic markers: A systematic review and meta-analysis of clinical trials.

Pharmacol Res 2018 Sep 9;135:144-149. Epub 2018 Aug 9.

Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Canoas 100, Col. Los Angeles 34067, Durango, Dgo., Mexico. Electronic address:

Ursodeoxycholic acid (UDCA) is widely used to treat liver diseases; however, its potential effect on metabolic parameters has been poorly investigated. Additionally, owing to divergent data, the objective of this meta-analysis was to evaluate the effect of UDCA on glycemic parameters in clinical trials. Clinical trials investigating the impact of UDCA treatment on glycemic markers were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases (from inception to April 16, 2018). Read More

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http://dx.doi.org/10.1016/j.phrs.2018.08.008DOI Listing
September 2018