934 results match your criteria Journal of Pharmacy Practice[Journal]


Psychiatric Manifestations With Sacubitril/Valsartan: A Case Report.

J Pharm Pract 2019 Apr 16:897190019842700. Epub 2019 Apr 16.

1 University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Tyler, TX, USA.

Sacubitril/valsartan is an angiotensin receptor-neprilysin inhibitor approved for the treatment of heart failure with reduced ejection fraction (HFrEF). Valsartan is well studied, but sacubitril has much left to understand. This report describes a 31-year-old African American female diagnosed with HFrEF who presented with a 7-day history of psychiatric symptoms following a dose increase in sacubitril/valsartan. Read More

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http://dx.doi.org/10.1177/0897190019842700DOI Listing
April 2019
1 Read

Impact of Reported β-Lactam Allergy on Management of Methicillin-Sensitive Staphylococcus aureus Bloodstream Infections.

J Pharm Pract 2019 Apr 16:897190019841737. Epub 2019 Apr 16.

1 Henry Ford Hospital, Detroit, MI, USA.

Background: Antistaphylococcal β-lactams antibiotics are the preferred treatment for methicillin-sensitive Staphylococcus aureus (MSSA) infections. Patient-reported β-lactam allergies may complicate antibiotic decision-making and delay optimal therapy, with potential implications on patient outcomes.

Objective: To determine the impact of reported β-lactam allergies on the receipt of optimal therapy and outcomes for MSSA bloodstream infections (BSI). Read More

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http://dx.doi.org/10.1177/0897190019841737DOI Listing

Diffuse Alveolar Hemorrhage Following Pirfenidone Initiation.

J Pharm Pract 2019 Apr 15:897190019841731. Epub 2019 Apr 15.

3 Pharmacy Practice and Medicine, Creighton University School of Pharmacy and Health Professions, Omaha, NE, USA.

Introduction: Diffuse alveolar hemorrhage (DAH) is bleeding into the alveolar space of the lungs. Pirfenidone is an antifibrotic agent that is approved for the treatment of idiopathic pulmonary fibrosis (IPF). The most commonly reported side effects include gastrointestinal and skin-related events. Read More

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http://dx.doi.org/10.1177/0897190019841731DOI Listing
April 2019
3 Reads

Community Pharmacist Utilization of Legislation That Allows Impact on the Opioid Crisis in the State of Minnesota: A Mixed-Methods Approach.

J Pharm Pract 2019 Apr 14:897190019841747. Epub 2019 Apr 14.

1 Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota College of Pharmacy, Duluth, MN, USA.

Background: As opioid overdose deaths climb, legislation supporting pharmacists in developing their role to address the crisis has expanded. Although Minnesota pharmacists are encouraged to utilize opiate antagonist, syringe access and authorized collector legislation, the use patterns of these tools are unknown.

Methods: A mixed-methods approach was used to survey 8405 Minnesota-licensed pharmacists on their practices related to the opioid crisis. Read More

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http://dx.doi.org/10.1177/0897190019841747DOI Listing
April 2019
1 Read

Delayed Cardiotoxicity From a Massive Nortriptyline Overdose Requiring Prolonged Treatment.

J Pharm Pract 2019 Apr 14:897190019838700. Epub 2019 Apr 14.

1 Department of Pharmacy, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Purpose: A case of a nortriptyline overdose complicated by delayed ventricular arrhythmias necessitating prolonged sodium bicarbonate infusion is presented, along with a review of tricyclic antidepressant (TCA) toxicology and key concepts for massive overdose management.

Summary: A 61-year-old man presented after an intentional nortriptyline overdose with a possible consumption of up to 2500 mg of nortriptyline. Electrocardiogram on presentation demonstrated QRS widening to 240 milliseconds. Read More

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http://dx.doi.org/10.1177/0897190019838700DOI Listing
April 2019
3 Reads

Primary Care Provider Perceptions of Pharmacist Services in an Urban, Safety Net Health System.

J Pharm Pract 2019 Apr 12:897190019838422. Epub 2019 Apr 12.

2 Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, CA, USA.

While pharmacists have provided services in a multidisciplinary, primary care setting for decades, few publications have yet to evaluate providers' impressions of- these services. An anonymous 14-item survey distributed to nonresident primary care providers aimed to identify clinical pharmacist services that are most and least helpful to primary care providers, identify barriers to pharmacy services, and develop recommendations to improve pharmacy services in primary care. The most important pharmacist contribution identified by providers is medication management, whereas the least important contributions are case conference, panel management, quality improvement, and transition of care. Read More

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http://dx.doi.org/10.1177/0897190019838422DOI Listing

Time to Stop Looking at Alteplase for Stroke Through a Prism.

J Pharm Pract 2019 Apr 9:897190019840116. Epub 2019 Apr 9.

1 Department of Pharmacy, Wesley Medical Center, Wichita, KS, USA.

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http://dx.doi.org/10.1177/0897190019840116DOI Listing

A Successful Phase II Residency Match-Insights From a Program.

J Pharm Pract 2019 Apr 9:897190019841738. Epub 2019 Apr 9.

1 Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, College of Pharmacy, Knoxville, TN, USA.

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http://dx.doi.org/10.1177/0897190019841738DOI Listing

Pharmacologic Considerations Surrounding Sedation, Delirium, and Sleep in Critically Ill Adults: A Narrative Review.

J Pharm Pract 2019 Apr 7:897190019840120. Epub 2019 Apr 7.

2 Department of Pharmacy, Surgical Intensive Care Unit, New York-Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY, USA.

Introduction:: Agitation, delirium, and sleep dysfunction in the intensive care unit (ICU) are common occurrences that result in negative patient outcomes. With the recent publication of the 2018 Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU (PAD-IS), several areas are of particular interest due to emerging literature or conflicting results of research.

Objective:: To highlight areas where emerging literature or variable study results exist and to provide the clinician with recommendations regarding patient management. Read More

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http://dx.doi.org/10.1177/0897190019840120DOI Listing
April 2019
2 Reads

Examination of Barriers to Medication Adherence, Asthma Management, and Control Among Community Pharmacy Patients With Asthma.

J Pharm Pract 2019 Apr 4:897190019840117. Epub 2019 Apr 4.

3 Shire Plc, Lexington, MA, USA.

Objective:: To describe the prevalence of common barriers to asthma medication adherence and examine associations between patient-reported asthma controller adherence and asthma control, therapy adherence barriers, and asthma management characteristics.

Methods:: Previously developed asthma-specific tool was pilot tested on a convenience sample of adult patients with persistent asthma. The following data were collected via patient survey: demographic characteristics and comorbidities, adherence, asthma control, and asthma management characteristics. Read More

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http://dx.doi.org/10.1177/0897190019840117DOI Listing
April 2019
2 Reads

Pharmacist-Managed Inpatient Dofetilide Initiation Program: Description and Adherence Rate Post-Root Cause Analysis.

J Pharm Pract 2019 Apr 2:897190019834130. Epub 2019 Apr 2.

4 Department of Pharmacy Practice, Maine Medical Center, Portland, ME, USA.

The aim of this article is to describe the pharmacist-managed dofetilide initiation program at Maine Medical Center (MMC), assess the adherence rate to 8 core clinical metrics, and review adverse effects before and after a root cause analysis (RCA). Core clinical metrics included pharmacist note entered within 4 hours of dose administration, dose chosen correctly per renal function, QTc measurements obtained and reviewed 2 hours after each dose, appropriate dose adjustment per the most recent QTc measurement, documentation of patient education, and assessment of conduction abnormality, drug-drug interactions, and serum potassium and magnesium concentrations. The primary outcome was adherence rate to all 8 core clinical metrics before and after the RCA. Read More

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http://journals.sagepub.com/doi/10.1177/0897190019834130
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http://dx.doi.org/10.1177/0897190019834130DOI Listing
April 2019
5 Reads

INR Management of an Antiphospholipid Syndrome Patient With Point-of-Care INR Testing.

J Pharm Pract 2019 Mar 27:897190019838192. Epub 2019 Mar 27.

1 Department of Pharmacy, The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.

Management of patients with antiphospholipid syndrome on warfarin therapy can be challenging. The international normalized ratio (INR) of patients with antiphospholipid syndrome can be falsely elevated. This elevation is thought to be reflective of the reaction of the antiphospholipid antibody with the thromboplastin used to measure the protime. Read More

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http://dx.doi.org/10.1177/0897190019838192DOI Listing
March 2019
2 Reads

Neutropenia-Associated Outcomes in Patients With Breast Cancer Receiving Myelosuppressive Chemotherapy With Reduced Doses of Pegfilgrastim.

J Pharm Pract 2019 Mar 27:897190019838374. Epub 2019 Mar 27.

1 Department of Pharmacy, Atrium Health, Levine Cancer Institute, Charlotte, NC, USA.

Background:: Pegfilgrastim can be utilized to prevent neutropenia-associated complications in patients receiving myelosuppressive chemotherapy for breast cancer. A common adverse event associated with pegfilgrastim is bone pain. Clinicians may opt to reduce the dose of pegfilgrastim when administering it to patients with previous severe or refractory bone pain. Read More

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http://dx.doi.org/10.1177/0897190019838374DOI Listing
March 2019
1 Read

Lansoprazole-Induced Thrombocytopenia in a Critically Ill Patient: A Case Report.

J Pharm Pract 2019 Mar 27:897190019838681. Epub 2019 Mar 27.

1 Pharmacy Department, Al Wakra Hospital, Hamad Medical Corporation, Al Wakrah, Qatar.

Introduction:: Proton pump inhibitors (PPIs) may rarely cause thrombocytopenia. To our knowledge, only one case of lansoprazole-induced thrombocytopenia has been reported previously.

Case:: We report a case of a 50-year-old South Asian male who was admitted to the intensive care unit (ICU) after cardiac arrest during general anesthesia for ureteroscopy. Read More

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http://dx.doi.org/10.1177/0897190019838681DOI Listing

Management of Pulmonary Arterial Hypertension in the ICU.

Authors:
Heather Torbic

J Pharm Pract 2019 Mar 25:897190019838110. Epub 2019 Mar 25.

1 Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.

Patients with pulmonary arterial hypertension (PAH) who are admitted to the intensive care unit (ICU) pose a challenge to the multidisciplinary health-care team due to the complexity of the pathophysiology of their disease state and the medication considerations that must be made to appropriately manage them. PAH is a progressive disease with the majority of patients ultimately dying as a result of right ventricular (RV) failure. During an acute decompensation, patients must be appropriately managed to optimize volume status, RV function, cardiac output, and systemic perfusion, while treating the underlying cause of the exacerbation. Read More

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http://dx.doi.org/10.1177/0897190019838110DOI Listing
March 2019
9 Reads

Moxifloxacin-Induced Visual Hallucinations, Alterations in Mood and Behavior, and Hyperglycemia.

Authors:
Burak Uz

J Pharm Pract 2019 Mar 21:897190019830567. Epub 2019 Mar 21.

1 Adult Hematology Clinic, Medicana International Samsun Hospital, Samsun, Turkey.

Visual hallucinations are sensory perceptions that occur without external stimuli. Moxifloxacin-induced visual hallucinations are very rarely reported (<0.1%). Read More

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http://journals.sagepub.com/doi/10.1177/0897190019830567
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http://dx.doi.org/10.1177/0897190019830567DOI Listing
March 2019
1 Read

Vancomycin Area Under the Curve Dosing and Monitoring at an Academic Medical Center: Transition Strategies and Lessons Learned.

J Pharm Pract 2019 Mar 10:897190019834369. Epub 2019 Mar 10.

2 Department of Pharmacy Services, UK HealthCare, Lexington, KY, USA.

Due to the inconsistent correlation of vancomycin trough concentrations with 24-hour area under the curve (AUC) and a desire to reduce rates of vancomycin-associated acute kidney injury, an institutional guideline was implemented by the Antimicrobial Stewardship Team in September 2017 to monitor vancomycin using AUC. Three stages were utilized to organize the process: preparation, implementation, and evaluation. The preparation stage was used to present literature to key stakeholders, and pharmacy meetings focused on the development of a dosing and monitoring guideline. Read More

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http://dx.doi.org/10.1177/0897190019834369DOI Listing
March 2019
1 Read

Evaluation of a Computerized Insulin Dosing Tool for the Treatment of Diabetic Ketoacidosis.

J Pharm Pract 2019 Mar 10:897190019834367. Epub 2019 Mar 10.

2 Kaleida Health, Buffalo General Medical Center, Buffalo, New York, USA.

Purpose:: Computerized insulin dosing tools (CIDT) have been shown to improve the care of critically ill patients with hyperglycemia. Application of a CIDT in addition to a diabetic ketoacidosis (DKA) order set for the treatment of DKA has not been evaluated. Our goal was to determine the effects the CIDT would have on the treatment of a patient with DKA. Read More

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http://dx.doi.org/10.1177/0897190019834367DOI Listing
March 2019
1 Read

Management of Endocrine Emergencies in the ICU.

Authors:
Judith Jacobi

J Pharm Pract 2019 Mar 10:897190019834771. Epub 2019 Mar 10.

1 Pharmacy Department, Indiana University Health Methodist Hospital, Indianapolis, IN, USA.

Endocrine emergencies are frequent in critically ill patients and may be the cause of admission or can be secondary to other critical illness. The ability to anticipate endocrine abnormalities such as adrenal excess or , hypothyroidism, can mitigate their duration and severity. Hyperglycemic crisis may trigger hospital and intensive care unit (ICU) admission and may be life threatening. Read More

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http://dx.doi.org/10.1177/0897190019834771DOI Listing
March 2019
1 Read

Beyond Opioids for Pain Management in Adult Critically Ill Patients.

J Pharm Pract 2019 Mar 7:897190019834479. Epub 2019 Mar 7.

1 Department of Pharmacy, Maine Medical Center, Portland, ME, USA.

Critically ill patients commonly experience pain, and the provision of analgesia is an essential component of intensive care unit (ICU) care. Opioids are the mainstay of pain management in the ICU but are limited by their adverse effects, risk of addiction and abuse, and recent drug shortages of injectable formulations. A multimodal analgesia approach, utilizing nonopioid analgesics as adjuncts to opioid therapy, is recommended since they may modulate the pain response and reduce opioid requirements by acting on multiple pain mediators. Read More

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http://dx.doi.org/10.1177/0897190019834479DOI Listing
March 2019
2 Reads

An Analysis of Psychoactive Medications Initiated in the ICU but Continued Beyond Discharge: A Pilot Study of Stewardship.

J Pharm Pract 2019 Feb 27:897190019830518. Epub 2019 Feb 27.

3 Maine Medical Center, Portland, ME, USA.

Background:: Psychoactive medications (PM) are frequently administered in the intensive care unit (ICU) to provide comfort. Interventions focused on preventing their continuation after the acute phase of illness are needed.

Objective:: To determine the frequency that patients with ICU-initiated PM are continued upon ICU and hospital discharge. Read More

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http://dx.doi.org/10.1177/0897190019830518DOI Listing
February 2019

Impact of a Pharmacy-Initiated Inpatient Diabetes Patient Education Program on 30-Day Readmission Rates.

J Pharm Pract 2019 Feb 27:897190019833217. Epub 2019 Feb 27.

5 Department of Pharmacy, Cleveland Clinic Euclid Hospital, Euclid, OH, USA.

Background:: In October 2012, a pharmacy-driven Inpatient Diabetes Patient Education (IDPE) program was implemented at the University of Toledo Medical Center (UTMC).

Objective:: To determine the difference in 30-day hospital readmission rates for patients who receive IDPE compared to those who do not.

Methods:: This retrospective cohort was completed at UTMC. Read More

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http://dx.doi.org/10.1177/0897190019833217DOI Listing
February 2019
1 Read

Vancomycin-Associated Acute Kidney Injury in Critically Ill Adolescent and Young Adult Patients.

J Pharm Pract 2019 Feb 26:897190019829652. Epub 2019 Feb 26.

2 Department of Pharmacy, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA.

Background:: Risk factors for the development of vancomycin-associated acute kidney injury (AKI) have been evaluated in both pediatric and adult populations; however, no previous studies exist evaluating this in the critically ill adolescent and young adult patients.

Objective:: Identify the incidence of AKI and examine risk factors for the development of AKI in critically ill adolescents and young adults on vancomycin.

Methods:: This retrospective review evaluated the incidence of AKI in patients 15 to 25 years of age who received vancomycin, while admitted to an intensive care unit. Read More

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http://dx.doi.org/10.1177/0897190019829652DOI Listing
February 2019
2 Reads

Evaluation of Pharmacist Involvement in Medicare Wellness Visits.

J Pharm Pract 2019 Feb 26:897190019827126. Epub 2019 Feb 26.

1 Baylor Scott & White Health-Temple, TX, USA.

Purpose:: To evaluate the difference in the number of drug therapy interventions between patients seen by pharmacists and patients seen by nonpharmacist providers during Medicare Annual Wellness Visits (AWVs).

Methods:: Pharmacists completed the medication history portion of AWVs at a primary care, interdisciplinary clinic in Central Texas. Drug therapy problems were collected and compared to those identified by physicians conducting AWVs. Read More

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http://dx.doi.org/10.1177/0897190019827126DOI Listing
February 2019
1 Read

Advancing Infectious Diseases Diagnostic Testing and Applications to Antimicrobial Therapy in the ICU.

J Pharm Pract 2019 Feb 26:897190019831162. Epub 2019 Feb 26.

2 Department of Pharmacy, Medical Intensive Care Unit, Cleveland Clinic, Cleveland, OH, USA.

Treatment of suspected infections in critically ill patients requires the timely initiation of appropriate antimicrobials and rapid de-escalation of unnecessary broad-spectrum coverage. New advances in rapid diagnostic tests can now offer earlier detection of pathogen and potential resistance mechanisms within hours of initial culture growth. These technologies, combined with pharmacist antimicrobial stewardship efforts, may result in shorten time to adequate coverage or earlier de-escalation of unnecessary broad spectrum antimicrobials, which could improve patient outcomes and lower overall treatment cost. Read More

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http://dx.doi.org/10.1177/0897190019831162DOI Listing
February 2019

Aiming Beyond: A Pharmacist Impact on 90-Day Readmissions and Clinical Outcomes Within a Family Medicine Service.

J Pharm Pract 2019 Feb 25:897190019825970. Epub 2019 Feb 25.

2 Department of Family and Community Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Previous studies have shown pharmacists positively impact 30-day readmission rates. However, there is limited data regarding the effect of clinical pharmacist (CP) follow-up on 90-day readmission or evaluation of disease-specific goals after hospitalization. Investigators analyzed the impact of postdischarge extended CP follow-up within a family medicine service (FMS). Read More

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http://dx.doi.org/10.1177/0897190019825970DOI Listing
February 2019
1 Read

Key Articles and Guidelines in the Management of Heart Failure: 2018 Update.

J Pharm Pract 2019 Feb 19;32(1):77-92. Epub 2018 Dec 19.

7 University of Missouri Kansas City, Kansas City, MO, USA.

Heart failure is one of the leading causes of hospitalizations in the United States, with >1 million admissions yearly and a 25% risk of readmissions within 1 month. In order to assist clinicians, we provide an update of the heart failure bibliography that was published in Pharmacotherapy in 2008, which followed the original bibliography published in 2004. A significant number of clinical trials and observational studies have been conducted since the early 1980s to guide management of heart failure patients. Read More

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http://dx.doi.org/10.1177/0897190018819413DOI Listing
February 2019
1 Read

Moderate to Severe Acute Respiratory Distress Syndrome Management Strategies: A Narrative Review.

J Pharm Pract 2019 Feb 21:897190019830504. Epub 2019 Feb 21.

3 Department of Pharmacy Practice, University of Maryland School of Pharmacy, Baltimore, MD, USA.

Acute respiratory distress syndrome (ARDS) remains a common complication associated with significant negative outcomes in critically ill patients. Lung-protective mechanical ventilation strategies remain the cornerstone in the management of ARDS. Several therapeutic options are currently available including fluid management, neuromuscular blocking agents, prone positioning, extracorporeal membrane oxygenation, corticosteroids, and inhaled pulmonary vasodilating agents (prostacyclins and nitric oxide). Read More

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http://dx.doi.org/10.1177/0897190019830504DOI Listing
February 2019
1 Read

Incorporation of Clinical Pharmacy Into a Geriatric Transitional Care Management Program.

J Pharm Pract 2019 Feb 21:897190019830502. Epub 2019 Feb 21.

1 University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.

Transitional care management (TCM) programs have been shown to decrease hospital readmission rates, health-care costs, and medication-related errors and adverse drug events. Pharmacists have been utilized during the medication reconciliation process, during admission, and after hospital discharge to prevent readmission and identify medication discrepancies. There is a lack of data utilizing clinical pharmacists in the geriatric patient population transitional care process after hospital discharge. Read More

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http://dx.doi.org/10.1177/0897190019830502DOI Listing
February 2019

Implementation of a Pilot Pharmacist Testosterone Therapy Management Service.

J Pharm Pract 2019 Feb 21:897190019830251. Epub 2019 Feb 21.

1 William S. Middleton Memorial Veteran Affairs Hospital, Madison, WI, USA.

Background:: Recent literature findings suggest that opportunities exist to optimize testosterone replacement therapy management.

Objective:: To evaluate the impact of a pilot clinical pharmacist testosterone therapy management service in a Veterans Affairs primary care setting.

Methods:: A 6-month, single-clinic, prospective cohort quality improvement project included male patients with an active prescription for testosterone. Read More

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http://dx.doi.org/10.1177/0897190019830251DOI Listing
February 2019

Appropriateness of Direct Oral Anticoagulant Dosing in Patients With Atrial Fibrillation: Insights From the Veterans Health Administration.

J Pharm Pract 2019 Feb 21:897190019828270. Epub 2019 Feb 21.

1 Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Background:: Direct oral anticoagulants (DOACs) have strict dosing guidelines, but recent studies indicate that inappropriate dosing is common, particularly in chronic kidney disease (CKD), for which it has been reported to be as high as 43%. Since 2011, the Veterans Health Administration (VA) has implemented anticoagulation management programs for DOACs, generally led by pharmacists, which has previously been shown to improve medication adherence.

Objective:: We investigated the prevalence of overdosing and underdosing of DOACs in the VA. Read More

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http://dx.doi.org/10.1177/0897190019828270DOI Listing
February 2019

The Potential Clinical Implications and Importance of Drug Interactions Between Anticancer Agents and Cannabidiol in Patients With Cancer.

J Pharm Pract 2019 Feb 18:897190019828920. Epub 2019 Feb 18.

2 Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, USA.

The objective of this review was to identify and examine the pharmacokinetic and pharmacodynamic interactions between cannabidiol (CBD)-only products, such as CBD oil, and anticancer agents. A literature search of PubMed (1980 to September 2018) and the Cochrane Collection (1980 to September 2018) was performed using the following search terms: "cannabidiol," "cancer," "cannabis," "marijuana," and "interaction," as well as any combination of these terms. Literature was excluded if it did not appear in the search when limited to the "full text" filter on PubMed, if it was not published in the English language, or if it did not explore potential pharmacodynamic or pharmacokinetic interactions of CBD and anticancer agents. Read More

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http://dx.doi.org/10.1177/0897190019828920DOI Listing
February 2019
5 Reads

Sacubitril/Valsartan (Entresto®)-Induced Hyponatremia.

J Pharm Pract 2019 Feb 18:897190019828915. Epub 2019 Feb 18.

1 College of Pharmacy and Health Sciences, St. John's University, Jamaica, NY, USA.

Sacubitril/valsartan (Entresto®) is the first commercially available angiotensin receptor neprilysin inhibitor (ARNI) approved for use in heart failure patients with a reduced ejection fraction. It is a combination drug that contains sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Our report outlines a case of probable ARNI-induced hyponatremia occurring in an elderly woman with heart failure with a reduced ejection fraction. Read More

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http://dx.doi.org/10.1177/0897190019828915DOI Listing
February 2019
1 Read

Real-World Effectiveness of High- Versus Moderate-Intensity Statin Therapy in Thai Patients With Acute Coronary Syndrome and Who Had Undergone Primary Percutaneous Coronary Intervention.

J Pharm Pract 2019 Feb 18:897190019825915. Epub 2019 Feb 18.

1 Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

Although high-intensity statins are recommended for atherosclerotic cardiovascular disease, evidence has shown that Asians may need lower dose statins to achieve similar effect when compared to Caucasians. Moreover, awareness of adverse effects leads physicians to initiate moderate-intensity statins. Comparative of high versus moderate-intensive statins on LDL-C among patients who had undergone primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) are less established in Thailand. Read More

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http://dx.doi.org/10.1177/0897190019825915DOI Listing
February 2019
1 Read

Long-Term Efficacy of Oral Vancomycin Prophylaxis for the Prevention of Clostridium difficile Recurrence.

J Pharm Pract 2019 Feb 11:897190019825994. Epub 2019 Feb 11.

1 Department of Pharmacy Services, Montefiore Nyack Hospital, Nyack, NY, USA.

Background:: Limited evidence suggests that prophylactic oral vancomycin may be beneficial in preventing Clostridium difficile infection (CDI) recurrence, but long-term efficacy is unknown.

Objective:: To evaluate the long-term efficacy of oral vancomycin prophylaxis (OVP) in preventing CDI recurrence in subjects who require subsequent antibiotic exposure.

Methods:: A retrospective cohort study was conducted at a community hospital. Read More

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http://dx.doi.org/10.1177/0897190019825994DOI Listing
February 2019
1 Read

A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use.

J Pharm Pract 2019 Feb 6:897190019825584. Epub 2019 Feb 6.

4 Division of Blood and Marrow Transplantation, Department of Medicine, UC San Diego Health, La Jolla, CA, USA.

Metronidazole is a nitroimidazole antibacterial agent that is highly effective for the treatment of protozoal and anaerobic infections. Metronidazole is known to cause hematologic adverse effects, including a reversible mild neutropenia; in rare circumstances, thrombocytopenia has been associated with metronidazole treatment. We present a case of aplastic anemia related to the extended use of metronidazole. Read More

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http://dx.doi.org/10.1177/0897190019825584DOI Listing
February 2019
8 Reads

Effect of Pharmacy-Driven Bedside Discharge Medication Delivery Program on Day 30 Hospital Readmission.

J Pharm Pract 2019 Feb 6:897190019825961. Epub 2019 Feb 6.

2 Transitions of Care, Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.

Background:: Previous studies demonstrated that transitions of care bundles, which include bedside discharge medication delivery (BDMD), may be helpful in decreasing hospital readmissions.

Objective:: To evaluate the effects of BDMD alone on day 30 readmission rates.

Methods:: Retrospective, cohort study comparing those who received pharmacy-driven BDMD to usual discharge. Read More

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http://dx.doi.org/10.1177/0897190019825961DOI Listing
February 2019

Acquired Hemophilia A: A Case Report.

J Pharm Pract 2019 Feb 6:897190019826474. Epub 2019 Feb 6.

3 Surgical Intensive Care Unit Attending Physician, Department of Surgery, NYU Winthrop Hospital, Mineola, NY, USA.

Hemophilia A, also known as factor VIII deficiency, is a rare disorder caused by an insufficient level of factor VIII, an essential clotting protein. Hemophilia A can be inherited or acquired. Inherited hemophilia A is caused by a mutation to the factor VIII gene on the X chromosome, which is commonly passed down from parents to children. Read More

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http://dx.doi.org/10.1177/0897190019826474DOI Listing
February 2019
7 Reads

Clinical and Procedural Evaluation of a Pharmacy Pharmacokinetic Consult Service.

J Pharm Pract 2019 Feb 6:897190019826484. Epub 2019 Feb 6.

2 Department of Pharmacy Services, University of Virginia Health System, Charlottesville, VA, USA.

Purpose:: Though previous studies have shown benefit with pharmacist-managed dosing of antibiotics, many institutions still do not offer such services. Our objective was to determine and report novel outcomes associated with the implementation of a pharmacist-managed pharmacokinetic/pharmacodynamic consult service and to assess the impact of direct pharmacist involvement in therapeutic drug monitoring.

Methods:: Retrospective cohort study of patients who received vancomycin or an aminoglycoside in the medical intensive care unit from January 5, 2013, to January 6, 2015, divided into 2 groups: before/after implementation of the consult service on January 6, 2014. Read More

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http://dx.doi.org/10.1177/0897190019826484DOI Listing
February 2019
1 Read

Possible GoLytely-Associated Cardiac Arrest: A Case Report and Literature Review.

J Pharm Pract 2019 Feb 6:897190019825965. Epub 2019 Feb 6.

3 Division of Critical Care Medicine, Department of Medicine, The Brooklyn Hospital Center, Brooklyn, NY, USA.

Purpose:: To report a case of sudden cardiac arrest possibly associated with the administration of GoLytely (polyethylene glycol 3350 and electrolytes).

Summary:: A 60-year-old male with a history of hypertension, hyperlipidemia, type 2 diabetes, and coronary artery disease presented to the emergency department with complaints of constipation and lower abdominal pain over the past week, and the inability to urinate over the past day. The patient had received GoLytely as treatment to alleviate symptoms of constipation and abdominal pain. Read More

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http://dx.doi.org/10.1177/0897190019825965DOI Listing
February 2019
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Timing of Anticoagulation in Atrial Fibrillation Status Post Cardioembolic Stroke.

J Pharm Pract 2019 Jan 31:897190019825577. Epub 2019 Jan 31.

2 Pharmacy Practice Department, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA.

Background:: Anticoagulation is the mainstay of secondary stroke prevention in patients with atrial fibrillation; however, few studies have assessed the optimal timing for initiation of anticoagulation post cardioembolic stroke. In the 2 weeks following an acute cardioembolic stroke, the risk of recurrent stroke is as high as 8%, but this risk must be balanced against the risk of hemorrhagic transformation with early initiation of anticoagulation.

Purpose:: This study described the time to initiation of anticoagulation and evaluated the in-hospital incidence of hemorrhagic and ischemic complications in 106 patients with atrial fibrillation post an acute cardioembolic stroke. Read More

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http://dx.doi.org/10.1177/0897190019825577DOI Listing
January 2019
17 Reads

Adherence to Disease-Modifying Therapies at a Multiple Sclerosis Clinic: The Role of the Specialty Pharmacist.

J Pharm Pract 2019 Jan 30:897190018824821. Epub 2019 Jan 30.

1 Vanderbilt Specialty Pharmacy Services, Vanderbilt University Medical Center, Nashville, TN, USA.

Background:: Disease-modifying therapy (DMT) delays disease progression and improves quality of life for patients with multiple sclerosis (MS), but adherence to DMT is often suboptimal. Vanderbilt Specialty Pharmacy (VSP) embeds pharmacists within an outpatient MS clinic to provide medication management and address barriers to adherence.

Objective:: We evaluated rates and predictors of adherence to DMT among patients with MS at an integrated specialty pharmacy. Read More

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http://journals.sagepub.com/doi/10.1177/0897190018824821
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http://dx.doi.org/10.1177/0897190018824821DOI Listing
January 2019
5 Reads

Pharmacist Statin Prescribing Initiative in Diabetic Patients at an Internal Medicine Resident Clinic.

J Pharm Pract 2019 Jan 29:897190018824820. Epub 2019 Jan 29.

1 The Moses H. Cone Memorial Hospital, Greensboro, NC, USA.

Background:: Despite general increases in statin use in the United States, statin therapy may be underutilized in diabetic patients and vulnerable populations.

Objective:: To determine the impact of a collaborative pharmacist initiative on statin prescribing for diabetic patients in an internal medicine residency clinic. The primary outcome was the change in prevalence of patients on statin therapy before and after intervention implementation. Read More

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http://dx.doi.org/10.1177/0897190018824820DOI Listing
January 2019
1 Read

Energy Drink-Induced Breakthrough Seizure in a Patient on Valproic Acid-Considering Herbal Safety in Epilepsy.

J Pharm Pract 2019 Jan 22:897190018825029. Epub 2019 Jan 22.

3 Department of Neurology, St. Louis University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1177/0897190018825029DOI Listing
January 2019

Community Pharmacists' Perceptions of Care Following the Implementation of a Transitions-of-Care Program.

J Pharm Pract 2019 Jan 22:897190018824819. Epub 2019 Jan 22.

1 Center for Pharmacy Innovation and Outcomes, Geisinger Health System, Danville, PA, USA.

Background:: Pharmacist-led collaborative interventions can support improved medication use and adherence during transitions of care (TOC). Community pharmacists are not always actively connected with other health-care team professionals, however, and their confidence in having necessary information may vary.

Objective:: To assess community pharmacists' perceptions of information, care provided, and communication, before and after a postdischarge intervention designed to increase communication between inpatient and community pharmacists. Read More

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http://dx.doi.org/10.1177/0897190018824819DOI Listing
January 2019
4 Reads

Evaluating the Standardization of Transitions of Care in a Texas-Mexico Border Academic Family Medicine Practice.

J Pharm Pract 2019 Jan 22:897190018824823. Epub 2019 Jan 22.

3 Department of Family and Community Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.

Purpose:: This quality improvement project aimed to assess the elements of the current workflow process that meets requirements for transitions of care from a family medicine inpatient to outpatient service following the Transitional Care Management (TCM) program developed by the Centers for Medicare & Medicaid Services. The purpose of the study was to assess the current family medicine workflow and determine whether the current process meets the criteria for billing and calculate the potential loss of reimbursement.

Methods:: Interviews with key personnel, review of practice policies, and a retrospective chart review were performed for clinic patients discharged from the inpatient to outpatient family medicine service. Read More

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http://journals.sagepub.com/doi/10.1177/0897190018824823
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http://dx.doi.org/10.1177/0897190018824823DOI Listing
January 2019
5 Reads

Knowledge, Perceptions, and Patterns of Fish Oil Use in Cardiac Patients.

J Pharm Pract 2019 Jan 22:897190018824485. Epub 2019 Jan 22.

1 Department of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, NE, USA.

Background:: Fish oils are the most widely used nonvitamin, nonmineral dietary supplements in the United States. They are not over-the-counter medications and are neither approved nor indicated for treating disease. Patient knowledge and patterns of fish oil use are not well defined. Read More

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http://dx.doi.org/10.1177/0897190018824485DOI Listing
January 2019
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A Case Report of Neurotoxicity After Prolonged Doses of Acyclovir in a Patient With Renal Dysfunction.

J Pharm Pract 2019 Jan 22:897190018825033. Epub 2019 Jan 22.

2 Houston Methodist Sugarland Hospital, Sugar Land, TX, USA.

Renal dysfunction is a significant risk factor for acyclovir-induced neurotoxicity and altered mentation and myoclonic movements are the most common clinical symptoms observed. In majority of reported cases, neurological sequelae associated with acyclovir-induced neurotoxicity often mimic viral infections of the central nervous system and makes diagnosis of the former challenging. Although plasma concentrations of the drug may not always correlate with neurotoxic symptoms, obtaining serum levels of acyclovir may be helpful in confirming drug-induced neurotoxicity. Read More

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http://dx.doi.org/10.1177/0897190018825033DOI Listing
January 2019

Chomping at the Bit: A Descriptive Report on Pediatric Clenbuterol Ingestion.

J Pharm Pract 2019 Jan 22:897190018823114. Epub 2019 Jan 22.

2 Department of Emergency Medicine, University of Kentucky-Chandler Medical Center, Lexington, KY, USA.

Introduction:: Clenbuterol hydrochloride is a selective beta-2 adrenergic agonist with uses in both humans and animals. Ingestions occurring within the United States are generally due to incidental ingestion of a veterinary product, use as a cutting agent for illicit substances, or illegal use for performance-enhancing purposes.

Case Report:: A four-and-a-half year-old male presented approximately two-and-a-half hours after an accidental ingestion of an unknown quantity of clenbuterol. Read More

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http://dx.doi.org/10.1177/0897190018823114DOI Listing
January 2019
2 Reads

Are Blacks at Higher Risk for Vancomycin-Related Acute Kidney Injury?

J Pharm Pract 2019 Jan 22:897190018800093. Epub 2019 Jan 22.

5 Department of Infectious Diseases, Ascension, St John Hospital & Medical Center, Detroit, MI, USA.

Background:: Black individuals have a higher lifetime risk of acute kidney injury (AKI) and chronic kidney disease than whites. Vancomycin has a potential for nephrotoxicity. The objective of this study was to determine whether the incidence of AKI among patients being treated with vancomycin differs by race. Read More

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http://dx.doi.org/10.1177/0897190018800093DOI Listing
January 2019
8 Reads