903 results match your criteria Journal of Pharmacy Practice[Journal]


The Potential Clinical Implications and Importance of Drug Interactions Between Anticancer Agents and Cannabidiol in Patients With Cancer.

J Pharm Pract 2019 Feb 18:897190019828920. Epub 2019 Feb 18.

2 Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Western New England University, Springfield, MA, USA.

The objective of this review was to identify and examine the pharmacokinetic and pharmacodynamic interactions between cannabidiol (CBD)-only products, such as CBD oil, and anticancer agents. A literature search of PubMed (1980 to September 2018) and the Cochrane Collection (1980 to September 2018) was performed using the following search terms: "cannabidiol," "cancer," "cannabis," "marijuana," and "interaction," as well as any combination of these terms. Literature was excluded if it did not appear in the search when limited to the "full text" filter on PubMed, if it was not published in the English language, or if it did not explore potential pharmacodynamic or pharmacokinetic interactions of CBD and anticancer agents. Read More

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http://dx.doi.org/10.1177/0897190019828920DOI Listing
February 2019

Sacubitril/Valsartan (Entresto®)-Induced Hyponatremia.

J Pharm Pract 2019 Feb 18:897190019828915. Epub 2019 Feb 18.

1 College of Pharmacy and Health Sciences, St. John's University, Jamaica, NY, USA.

Sacubitril/valsartan (Entresto®) is the first commercially available angiotensin receptor neprilysin inhibitor (ARNI) approved for use in heart failure patients with a reduced ejection fraction. It is a combination drug that contains sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Our report outlines a case of probable ARNI-induced hyponatremia occurring in an elderly woman with heart failure with a reduced ejection fraction. Read More

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http://dx.doi.org/10.1177/0897190019828915DOI Listing
February 2019

Real-World Effectiveness of High- Versus Moderate-Intensity Statin Therapy in Thai Patients With Acute Coronary Syndrome and Who Had Undergone Primary Percutaneous Coronary Intervention.

J Pharm Pract 2019 Feb 18:897190019825915. Epub 2019 Feb 18.

1 Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

Although high-intensity statins are recommended for atherosclerotic cardiovascular disease, evidence has shown that Asians may need lower dose statins to achieve similar effect when compared to Caucasians. Moreover, awareness of adverse effects leads physicians to initiate moderate-intensity statins. Comparative of high versus moderate-intensive statins on LDL-C among patients who had undergone primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) are less established in Thailand. Read More

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http://dx.doi.org/10.1177/0897190019825915DOI Listing
February 2019

Long-Term Efficacy of Oral Vancomycin Prophylaxis for the Prevention of Clostridium difficile Recurrence.

J Pharm Pract 2019 Feb 11:897190019825994. Epub 2019 Feb 11.

1 Department of Pharmacy Services, Montefiore Nyack Hospital, Nyack, NY, USA.

Background:: Limited evidence suggests that prophylactic oral vancomycin may be beneficial in preventing Clostridium difficile infection (CDI) recurrence, but long-term efficacy is unknown.

Objective:: To evaluate the long-term efficacy of oral vancomycin prophylaxis (OVP) in preventing CDI recurrence in subjects who require subsequent antibiotic exposure.

Methods:: A retrospective cohort study was conducted at a community hospital. Read More

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http://dx.doi.org/10.1177/0897190019825994DOI Listing
February 2019

A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use.

J Pharm Pract 2019 Feb 6:897190019825584. Epub 2019 Feb 6.

4 Division of Blood and Marrow Transplantation, Department of Medicine, UC San Diego Health, La Jolla, CA, USA.

Metronidazole is a nitroimidazole antibacterial agent that is highly effective for the treatment of protozoal and anaerobic infections. Metronidazole is known to cause hematologic adverse effects, including a reversible mild neutropenia; in rare circumstances, thrombocytopenia has been associated with metronidazole treatment. We present a case of aplastic anemia related to the extended use of metronidazole. Read More

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http://dx.doi.org/10.1177/0897190019825584DOI Listing
February 2019
1 Read

Effect of Pharmacy-Driven Bedside Discharge Medication Delivery Program on Day 30 Hospital Readmission.

J Pharm Pract 2019 Feb 6:897190019825961. Epub 2019 Feb 6.

2 Transitions of Care, Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.

Background:: Previous studies demonstrated that transitions of care bundles, which include bedside discharge medication delivery (BDMD), may be helpful in decreasing hospital readmissions.

Objective:: To evaluate the effects of BDMD alone on day 30 readmission rates.

Methods:: Retrospective, cohort study comparing those who received pharmacy-driven BDMD to usual discharge. Read More

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http://dx.doi.org/10.1177/0897190019825961DOI Listing
February 2019

Acquired Hemophilia A: A Case Report.

J Pharm Pract 2019 Feb 6:897190019826474. Epub 2019 Feb 6.

3 Surgical Intensive Care Unit Attending Physician, Department of Surgery, NYU Winthrop Hospital, Mineola, NY, USA.

Hemophilia A, also known as factor VIII deficiency, is a rare disorder caused by an insufficient level of factor VIII, an essential clotting protein. Hemophilia A can be inherited or acquired. Inherited hemophilia A is caused by a mutation to the factor VIII gene on the X chromosome, which is commonly passed down from parents to children. Read More

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http://dx.doi.org/10.1177/0897190019826474DOI Listing
February 2019
1 Read

Clinical and Procedural Evaluation of a Pharmacy Pharmacokinetic Consult Service.

J Pharm Pract 2019 Feb 6:897190019826484. Epub 2019 Feb 6.

2 Department of Pharmacy Services, University of Virginia Health System, Charlottesville, VA, USA.

Purpose:: Though previous studies have shown benefit with pharmacist-managed dosing of antibiotics, many institutions still do not offer such services. Our objective was to determine and report novel outcomes associated with the implementation of a pharmacist-managed pharmacokinetic/pharmacodynamic consult service and to assess the impact of direct pharmacist involvement in therapeutic drug monitoring.

Methods:: Retrospective cohort study of patients who received vancomycin or an aminoglycoside in the medical intensive care unit from January 5, 2013, to January 6, 2015, divided into 2 groups: before/after implementation of the consult service on January 6, 2014. Read More

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http://dx.doi.org/10.1177/0897190019826484DOI Listing
February 2019

Possible GoLytely-Associated Cardiac Arrest: A Case Report and Literature Review.

J Pharm Pract 2019 Feb 6:897190019825965. Epub 2019 Feb 6.

3 Division of Critical Care Medicine, Department of Medicine, The Brooklyn Hospital Center, Brooklyn, NY, USA.

Purpose:: To report a case of sudden cardiac arrest possibly associated with the administration of GoLytely (polyethylene glycol 3350 and electrolytes).

Summary:: A 60-year-old male with a history of hypertension, hyperlipidemia, type 2 diabetes, and coronary artery disease presented to the emergency department with complaints of constipation and lower abdominal pain over the past week, and the inability to urinate over the past day. The patient had received GoLytely as treatment to alleviate symptoms of constipation and abdominal pain. Read More

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http://dx.doi.org/10.1177/0897190019825965DOI Listing
February 2019
1 Read

Timing of Anticoagulation in Atrial Fibrillation Status Post Cardioembolic Stroke.

J Pharm Pract 2019 Jan 31:897190019825577. Epub 2019 Jan 31.

2 Pharmacy Practice Department, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA.

Background:: Anticoagulation is the mainstay of secondary stroke prevention in patients with atrial fibrillation; however, few studies have assessed the optimal timing for initiation of anticoagulation post cardioembolic stroke. In the 2 weeks following an acute cardioembolic stroke, the risk of recurrent stroke is as high as 8%, but this risk must be balanced against the risk of hemorrhagic transformation with early initiation of anticoagulation.

Purpose:: This study described the time to initiation of anticoagulation and evaluated the in-hospital incidence of hemorrhagic and ischemic complications in 106 patients with atrial fibrillation post an acute cardioembolic stroke. Read More

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http://dx.doi.org/10.1177/0897190019825577DOI Listing
January 2019
5 Reads

Adherence to Disease-Modifying Therapies at a Multiple Sclerosis Clinic: The Role of the Specialty Pharmacist.

J Pharm Pract 2019 Jan 30:897190018824821. Epub 2019 Jan 30.

1 Vanderbilt Specialty Pharmacy Services, Vanderbilt University Medical Center, Nashville, TN, USA.

Background:: Disease-modifying therapy (DMT) delays disease progression and improves quality of life for patients with multiple sclerosis (MS), but adherence to DMT is often suboptimal. Vanderbilt Specialty Pharmacy (VSP) embeds pharmacists within an outpatient MS clinic to provide medication management and address barriers to adherence.

Objective:: We evaluated rates and predictors of adherence to DMT among patients with MS at an integrated specialty pharmacy. Read More

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http://dx.doi.org/10.1177/0897190018824821DOI Listing
January 2019

Pharmacist Statin Prescribing Initiative in Diabetic Patients at an Internal Medicine Resident Clinic.

J Pharm Pract 2019 Jan 29:897190018824820. Epub 2019 Jan 29.

1 The Moses H. Cone Memorial Hospital, Greensboro, NC, USA.

Background:: Despite general increases in statin use in the United States, statin therapy may be underutilized in diabetic patients and vulnerable populations.

Objective:: To determine the impact of a collaborative pharmacist initiative on statin prescribing for diabetic patients in an internal medicine residency clinic. The primary outcome was the change in prevalence of patients on statin therapy before and after intervention implementation. Read More

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http://dx.doi.org/10.1177/0897190018824820DOI Listing
January 2019
1 Read

Energy Drink-Induced Breakthrough Seizure in a Patient on Valproic Acid-Considering Herbal Safety in Epilepsy.

J Pharm Pract 2019 Jan 22:897190018825029. Epub 2019 Jan 22.

3 Department of Neurology, St. Louis University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1177/0897190018825029DOI Listing
January 2019

Community Pharmacists' Perceptions of Care Following the Implementation of a Transitions-of-Care Program.

J Pharm Pract 2019 Jan 22:897190018824819. Epub 2019 Jan 22.

1 Center for Pharmacy Innovation and Outcomes, Geisinger Health System, Danville, PA, USA.

Background:: Pharmacist-led collaborative interventions can support improved medication use and adherence during transitions of care (TOC). Community pharmacists are not always actively connected with other health-care team professionals, however, and their confidence in having necessary information may vary.

Objective:: To assess community pharmacists' perceptions of information, care provided, and communication, before and after a postdischarge intervention designed to increase communication between inpatient and community pharmacists. Read More

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http://dx.doi.org/10.1177/0897190018824819DOI Listing
January 2019

Evaluating the Standardization of Transitions of Care in a Texas-Mexico Border Academic Family Medicine Practice.

J Pharm Pract 2019 Jan 22:897190018824823. Epub 2019 Jan 22.

3 Department of Family and Community Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.

Purpose:: This quality improvement project aimed to assess the elements of the current workflow process that meets requirements for transitions of care from a family medicine inpatient to outpatient service following the Transitional Care Management (TCM) program developed by the Centers for Medicare & Medicaid Services. The purpose of the study was to assess the current family medicine workflow and determine whether the current process meets the criteria for billing and calculate the potential loss of reimbursement.

Methods:: Interviews with key personnel, review of practice policies, and a retrospective chart review were performed for clinic patients discharged from the inpatient to outpatient family medicine service. Read More

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http://journals.sagepub.com/doi/10.1177/0897190018824823
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http://dx.doi.org/10.1177/0897190018824823DOI Listing
January 2019
5 Reads

Knowledge, Perceptions, and Patterns of Fish Oil Use in Cardiac Patients.

J Pharm Pract 2019 Jan 22:897190018824485. Epub 2019 Jan 22.

1 Department of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, NE, USA.

Background:: Fish oils are the most widely used nonvitamin, nonmineral dietary supplements in the United States. They are not over-the-counter medications and are neither approved nor indicated for treating disease. Patient knowledge and patterns of fish oil use are not well defined. Read More

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http://dx.doi.org/10.1177/0897190018824485DOI Listing
January 2019
1 Read

A Case Report of Neurotoxicity After Prolonged Doses of Acyclovir in a Patient With Renal Dysfunction.

J Pharm Pract 2019 Jan 22:897190018825033. Epub 2019 Jan 22.

2 Houston Methodist Sugarland Hospital, Sugar Land, TX, USA.

Renal dysfunction is a significant risk factor for acyclovir-induced neurotoxicity and altered mentation and myoclonic movements are the most common clinical symptoms observed. In majority of reported cases, neurological sequelae associated with acyclovir-induced neurotoxicity often mimic viral infections of the central nervous system and makes diagnosis of the former challenging. Although plasma concentrations of the drug may not always correlate with neurotoxic symptoms, obtaining serum levels of acyclovir may be helpful in confirming drug-induced neurotoxicity. Read More

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http://dx.doi.org/10.1177/0897190018825033DOI Listing
January 2019

Chomping at the Bit: A Descriptive Report on Pediatric Clenbuterol Ingestion.

J Pharm Pract 2019 Jan 22:897190018823114. Epub 2019 Jan 22.

2 Department of Emergency Medicine, University of Kentucky-Chandler Medical Center, Lexington, KY, USA.

Introduction:: Clenbuterol hydrochloride is a selective beta-2 adrenergic agonist with uses in both humans and animals. Ingestions occurring within the United States are generally due to incidental ingestion of a veterinary product, use as a cutting agent for illicit substances, or illegal use for performance-enhancing purposes.

Case Report:: A four-and-a-half year-old male presented approximately two-and-a-half hours after an accidental ingestion of an unknown quantity of clenbuterol. Read More

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http://dx.doi.org/10.1177/0897190018823114DOI Listing
January 2019
1 Read

Are Blacks at Higher Risk for Vancomycin-Related Acute Kidney Injury?

J Pharm Pract 2019 Jan 22:897190018800093. Epub 2019 Jan 22.

5 Department of Infectious Diseases, Ascension, St John Hospital & Medical Center, Detroit, MI, USA.

Background:: Black individuals have a higher lifetime risk of acute kidney injury (AKI) and chronic kidney disease than whites. Vancomycin has a potential for nephrotoxicity. The objective of this study was to determine whether the incidence of AKI among patients being treated with vancomycin differs by race. Read More

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http://dx.doi.org/10.1177/0897190018800093DOI Listing
January 2019
5 Reads

Ether for Wound Debridement of Wild Maggots.

J Pharm Pract 2019 Jan 20:897190018815390. Epub 2019 Jan 20.

1 Department of Pharmacy, Detroit Receiving Hospital, Detroit, MI, USA.

Myiasis is defined as an infestation of the organs or tissues of live vertebrates (humans or animals) by dipterous larvae, commonly referred to as maggots. Wound myiasis is a common presentation in the emergency department. The presence of wild maggots and larvae in wounds is concerning for subsequent myiasis-induced infections and complications. Read More

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http://dx.doi.org/10.1177/0897190018815390DOI Listing
January 2019
1 Read

Evaluation of a Clinical Pharmacist-Led Automated Dispensing Cabinet Stewardship Program at a Tertiary Academic Medical Center.

J Pharm Pract 2019 Jan 17:897190018823471. Epub 2019 Jan 17.

1 Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.

Background:: There is little guidance regarding the best methodology or frequency to optimize automated dispensing cabinets. Clinical pharmacists are in the unique position to make decisions regarding automated dispensing cabinet inventory to best serve their specific patient population.

Objective:: The purpose of this evaluation was to determine if automated dispensing cabinet optimization by clinical pharmacists would affect the number of dispenses from central pharmacy, number of stockouts, and inventory cost. Read More

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http://dx.doi.org/10.1177/0897190018823471DOI Listing
January 2019
3 Reads

Implementation of an Advanced Pharmacy Practice Model in the Emergency Department.

J Pharm Pract 2019 Jan 13:897190018819412. Epub 2019 Jan 13.

2 Department of Pharmacy Services, The Brooklyn Hospital Center, Brooklyn, NY, USA.

Study Objective:: The objective of this retrospective descriptive study was to quantify clinical activities performed by pharmacists in an advanced pharmacy practice model in the emergency department (ED).

Methods:: Data from January 2015 to August 2017 extracted from the department of pharmacy's electronic documentation system and the hospital's electronic medical record were collected and reviewed. Cost savings was derived from the system with adaptation from the previous literature and had been validated by our institution's administration as an acceptable reflection of the impact for activity. Read More

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http://dx.doi.org/10.1177/0897190018819412DOI Listing
January 2019

Evaluating the Use of Phenobarbital for the Management of Alcohol Withdrawal Syndrome in Psychiatric Inpatients.

J Pharm Pract 2019 Jan 10:897190018822561. Epub 2019 Jan 10.

2 SWGA Clinical Campus, University of Georgia College of Pharmacy, Albany, GA, USA.

Objectives:: To describe the potential role of phenobarbital as appropriate therapy in the treatment and prevention of alcohol withdrawal syndrome (AWS) among medically cleared psychiatric inpatients.

Methods:: This was a single-center, retrospective, observational study of adult patients admitted to the psychiatric unit and administered phenobarbital for the treatment or prevention of AWS. Changes in vital signs and signs and symptoms of AWS were observed to assess the safety and efficacy of phenobarbital. Read More

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http://dx.doi.org/10.1177/0897190018822561DOI Listing
January 2019
1 Read

A Systematic and Evidence-Based Review of Published and Pending Reports of Andexanet Alfa.

J Pharm Pract 2019 Jan 6:897190018822556. Epub 2019 Jan 6.

1 Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Shenandoah University, Winchester, VA, USA.

Andexanet alfa is the newly approved factor Xa inhibitor reversal agent for the treatment of life-threatening or uncontrolled bleeding from apixaban or rivaroxaban. This decoy protein directly binds factor Xa inhibitors reversing their action. A systematic and evidence-based evaluation of the available clinical trials is lacking in the literature. Read More

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http://dx.doi.org/10.1177/0897190018822556DOI Listing
January 2019

Anticoagulation of a Percutaneous Left Ventricular Assist Device Using a Low-Dose Heparin Purge Solution Protocol: A Case Series.

J Pharm Pract 2019 Jan 6:897190018822105. Epub 2019 Jan 6.

1 Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Augusta, GA, USA.

Background:: Impella CP® is a percutaneous left ventricular assist device that requires a heparin-dextrose purge solution. The manufacturer recommends heparin 50 units/mL, but supratherapeutic anticoagulation has been observed with this concentration.

Objective:: The purpose of this evaluation was to observe the efficacy and safety of a low-dose heparin-based purge solution (25 units/mL in dextrose 20%). Read More

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http://dx.doi.org/10.1177/0897190018822105DOI Listing
January 2019
1 Read

Accuracy of Medical Marijuana Claims Made by Popular Websites.

J Pharm Pract 2018 Dec 30:897190018818907. Epub 2018 Dec 30.

1 UMKC School of Pharmacy, Drug Information Center, Kansas City, MO, USA.

Background:: With increasing popularity of marijuana, consumers are likely turning to the internet for information regarding medical marijuana. Accuracy of medical marijuana claims is a significant concern because consumers change their medication management based on information from a single website.

Objective:: The purpose of this study was to evaluate the accuracy and quality of medical marijuana claims on popular websites. Read More

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http://journals.sagepub.com/doi/10.1177/0897190018818907
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http://dx.doi.org/10.1177/0897190018818907DOI Listing
December 2018
1 Read

Antibiotic Decision-Making Among Medical Residents, Medical Students, and Nurse Practitioners: A Single-Center Survey.

J Pharm Pract 2018 Dec 30:897190018821265. Epub 2018 Dec 30.

1 Department of Pharmacy, Jersey City Medical Center, Jersey City, NJ, USA.

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http://journals.sagepub.com/doi/10.1177/0897190018821265
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http://dx.doi.org/10.1177/0897190018821265DOI Listing
December 2018
1 Read

Impact of Timing Between Insulin Administration and Meal Consumption on Glycemic Fluctuation and Outcomes in Hospitalized Patients With Type 2 Diabetes.

J Pharm Pract 2018 Dec 25:897190018818908. Epub 2018 Dec 25.

1 Department of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore.

Background:: The effect of time interval from insulin injection to meal consumption ("insulin-meal") on glycemic fluctuation and outcomes is not well understood.

Objective:: This study aims to investigate the impact of coordinated versus mismatched insulin-meal administration on glycemic fluctuation and outcomes among hospitalized patients with type 2 diabetes (T2D).

Methods:: Hospitalized patients with T2D who received at least 1 dose of insulin as part of sliding scale regimen were included. Read More

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http://dx.doi.org/10.1177/0897190018818908DOI Listing
December 2018

Evaluation of a Simplified Risk Stratification Twice-Daily Aspirin Protocol for Venous Thromboembolism Prophylaxis After Total Joint Replacement.

J Pharm Pract 2018 Dec 20:897190018815050. Epub 2018 Dec 20.

2 Department of Orthopaedic Surgery and Rehabilitation, Loyola University Health System, Maywood, IL, USA.

Objective:: To determine using a simplified risk-stratified protocol to select candidates for aspirin therapy have similar death and postoperative complications as universal warfarin therapy in patients undergoing total joint replacement (TJR).

Methods:: Retrospective cohort study comparing 30-day postoperative outcomes 6 months before and after the implementation of the aspirin protocol (January 1, 2015) in patients undergoing TJR. The control group was comprised of patients using warfarin for VTE prophylaxis. Read More

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http://dx.doi.org/10.1177/0897190018815050DOI Listing
December 2018
1 Read

National Trends in Diabetes Medication Use in the United States: 2008 to 2015.

J Pharm Pract 2018 Dec 20:897190018815048. Epub 2018 Dec 20.

2 Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.

Background:: Data on trends of diabetes medications use are sparse, outdated, and limited to prescription data. We determined trends in diabetes medication use among US individuals with diabetes during 2008-2015.

Methods:: We used 2008-2015 Medical Expenditure Panel Survey to examine diabetes medication utilization among individuals aged ≥18 years with diabetes. Read More

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http://dx.doi.org/10.1177/0897190018815048DOI Listing
December 2018
5 Reads

First-Line Therapies for VTE Treatment and Secondary Prophylaxis in Patients With Cancer: A New Direction.

J Pharm Pract 2018 Dec 12:897190018775580. Epub 2018 Dec 12.

3 Cardiology, Seton Healthcare Family, Dell Seton Medical Center at the University of Texas at Austin, Seton Medical Center at Austin, Austin, TX, USA.

Objective:: To review evidence behind anticoagulants in cancer-associated venous thromboembolism (VTE) with a focus on low-molecular-weight heparins (LMWH) and the role of direct oral anticoagulants (DOACs).

Data Sources:: PubMed was searched using terms "venous thromboembolism," "cancer," and "anticoagulation." This search was restricted to clinical trials, meta-analyses, and subgroup analyses. Read More

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http://dx.doi.org/10.1177/0897190018775580DOI Listing
December 2018

Standardizing the Use of Albumin in Large Volume Paracentesis.

J Pharm Pract 2018 Dec 6:897190018816252. Epub 2018 Dec 6.

2 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background:: Albumin after large volume paracentesis (LVP) reduces paracentesis-induced circulatory dysfunction (PICD). The most efficacious dose of albumin for LVP is unclear.

Objective:: To evaluate the impact of implementing a standardized LVP order set on albumin utilization and patient outcomes. Read More

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http://dx.doi.org/10.1177/0897190018816252DOI Listing
December 2018
1 Read

Acute Care Pharmacy Practice: A Perspective for Pharmacy Students, Residents, and Other Health-Care Providers.

J Pharm Pract 2018 Dec 6:897190018816262. Epub 2018 Dec 6.

1 Department of Clinical Sciences, Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA.

Purpose:: To describe the acute care setting with a specific focus on acute care pharmacy practices.

Summary:: Acute care is the sector of health care where time-sensitive episodes of illness are managed. Acute care pharmacy practice includes both hospital and clinical pharmacists serving, in a variety of domains, as medication experts and authority on patient-centered medication therapy. Read More

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http://dx.doi.org/10.1177/0897190018816262DOI Listing
December 2018
1 Read

Early Experiences With PEGylated Carboxyhemoglobin Bovine in Anemic Jehovah's Witnesses: A Case Series and Review of the Literature.

J Pharm Pract 2018 Dec 5:897190018815373. Epub 2018 Dec 5.

1 Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.

Jehovah's Witnesses (JW) represent a complex patient population due to their refusal to accept blood transfusions on religious grounds. Pharmacologic management of anemic JW patients is limited to stimulation of hematopoiesis by iron and erythropoietin supplementation and reduction of blood loss by prothrombin complex concentrates (PCCs). Hemoglobin-based oxygen carriers (HBOCs) represent the only pharmacologic modality for JW patients capable of acutely increasing a patient's oxygen carrying capacity in the setting of organ failure, yet clinical safety and efficacy data are lacking in this population. Read More

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http://dx.doi.org/10.1177/0897190018815373DOI Listing
December 2018
2 Reads

Differences in Career Satisfaction, Work-life Balance, and Stress by Gender in a National Survey of Pharmacy Faculty.

J Pharm Pract 2018 Dec 5:897190018815042. Epub 2018 Dec 5.

1 College of Pharmacy, Touro University California, Vallejo, CA, USA.

Introduction:: The percentage of women pharmacy students and pharmacy faculty has greatly increased over the last 40 years. However, it is not known whether gender differences exist in terms of career satisfaction, work-life balance, and stress in the pharmacy academia workplace.

Methods:: Results from a national web-based survey administered to American Association of Colleges of Pharmacy (AACP) members were utilized. Read More

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http://dx.doi.org/10.1177/0897190018815042DOI Listing
December 2018
2 Reads

Development, Implementation, and Evaluation of Introductory Pharmacy Practice Experiences at an Academic Medical Center.

J Pharm Pract 2018 Nov 29:897190018810046. Epub 2018 Nov 29.

2 Department of Clinical Pharmacy, University of California at San Francisco, San Francisco, CA, USA.

Purpose:: Introductory pharmacy practice experiences (IPPEs) for pharmacy students are required by the Accreditation Council for Pharmacy Education, but guidance for rotational structure is limited.

Objective:: To describe the design, implementation, and evaluation of IPPE rotations at a large, multisite, academic medical center.

Conclusion:: A large IPPE program was successfully implemented and sustained. Read More

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http://dx.doi.org/10.1177/0897190018810046DOI Listing
November 2018

Reducing Medication Administration Frequency in Veteran Community Living Centers.

J Pharm Pract 2018 Nov 28:897190018815038. Epub 2018 Nov 28.

2 Pharmacy Service, Veterans Affairs Hudson Valley Health Care System (VA HVHCS), Wappingers Falls, NY, USA.

Background: A quality improvement initiative of the Veterans Health Administration (VHA) aims to reduce frequency of medication administration to Veterans per day. Medication administration practices in our community living center (CLC) units are similar to an acute care medical unit versus a home environment. The objective of this project was to reduce medication administration frequency in order to minimize the number of interruptions to both Veterans and nurses. Read More

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http://journals.sagepub.com/doi/10.1177/0897190018815038
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http://dx.doi.org/10.1177/0897190018815038DOI Listing
November 2018
3 Reads

Influenza and Intentions to Vaccinate in an Underserved Hispanic Population: The Role of Theoretically Derived Constructs.

J Pharm Pract 2018 Nov 19:897190018810595. Epub 2018 Nov 19.

1 University of Texas at El Paso School of Pharmacy, El Paso, TX, USA.

Background:: Past research has focused on understanding influenza vaccine acceptance in non-Hispanic white populations; however, research on the social causes of influenza vaccine acceptance rates in Hispanic populations is slowly developing.

Objective:: The purpose of this study was to assess theoretically driven predictors (i.e. Read More

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http://dx.doi.org/10.1177/0897190018810595DOI Listing
November 2018
5 Reads

Impact of Physician-Pharmacist Covisits at a Primary Care Clinic in Patients With Uncontrolled Diabetes.

J Pharm Pract 2018 Nov 14:897190018807374. Epub 2018 Nov 14.

2 Department of Pharmacy, The University of Texas at Austin, Austin, TX, USA.

Purpose:: A popular method for enhancing medication management within a patient-centered medical home (PCMH) is the physician-pharmacist collaborative management (PPCM) model. To improve efficiency of health-care delivery within 4 federally qualified health centers (FQHCs), the PPCM model was implemented through coordinated physician-pharmacist covisits.

Objective:: To evaluate the impact of physician-pharmacist covisits on clinical outcomes among patients with uncontrolled diabetes. Read More

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http://dx.doi.org/10.1177/0897190018807374DOI Listing
November 2018
9 Reads

Pharmacist-Initiated Management of a Suspected Case of Risperidone-Induced Neuroleptic Malignant Syndrome in an Aged-Care Resident. The Role of Residential Medication Management Reviews in Medication Safety.

J Pharm Pract 2018 Nov 14:897190018806414. Epub 2018 Nov 14.

1 Ward mm, Melbourne, Victoria, Australia.

A 70-year-old female aged-care resident was referred by her general practitioner for a residential medication management review after nurses reported difficulties with swallowing, episodes of hyperthermia, elevated blood pressure, and tachycardia. These symptoms were accompanied by increasing confusion and drowsiness. Risperidone had recently been prescribed to treat behavioral and psychological symptoms of dementia. Read More

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November 2018
9 Reads

Emerging Topics in Vaccine Therapeutics for Adolescents and Adults: An Update for Immunizing Pharmacists.

J Pharm Pract 2018 Oct 23:897190018802937. Epub 2018 Oct 23.

3 Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.

Vaccine therapeutics and the practice of immunization provision are ever-changing. As pharmacy-based immunization services continue to flourish in the United States, more and more patients are requesting both routine and travel vaccines in community pharmacies. However, vaccine recommendations from the Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices (CDC/ACIP) can sometimes differ from product-specific US Food and Drug Administration (FDA)-indicated uses. Read More

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October 2018
16 Reads

Measuring the Impact of Medication-Related Interventions on 30-Day Readmission Rates in a Skilled Nursing Facility.

J Pharm Pract 2018 Oct 21:897190018803229. Epub 2018 Oct 21.

4 Touro University College of Pharmacy, Vallejo, CA, USA.

Background: There is a lack of published literature that measures the impact of transitional care pharmacist (TCP) medication-related interventions within the skilled nursing facility (SNF) setting.

Objectives: To evaluate the impact of TCP medication-related interventions on 30-day hospital readmissions among SNF patients compared to current standard of care.

Methods: This was a retrospective pilot study. Read More

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October 2018

Evaluation of Clinical Pharmacist Services in a Transitions of Care Program Provided to Patients at Highest Risk for Readmission.

J Pharm Pract 2018 Oct 21:897190018806400. Epub 2018 Oct 21.

1 Pharmacy Innovations and Partnerships, Michigan Medicine, Ann Arbor, MI, USA.

Background: An ambulatory transition of care program, including a pharmacist-provided comprehensive medication review (CMR), was implemented.

Objectives: The objectives were to: (1) compare 30-day hospital readmission rates between those who received the pharmacist CMR versus eligible patients not scheduled, (2) describe identified problems and recommendations, and (3) quantify recommendation acceptance rates.

Methods: A retrospective cohort study was conducted between March and October 2016. Read More

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October 2018
11 Reads

Lacosamide Pharmacokinetics in a Critically Ill Patient During Continuous Renal Replacement Therapy.

J Pharm Pract 2018 Oct 18:897190018803765. Epub 2018 Oct 18.

1 Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.

The objective of this study is to describe the pharmacokinetics of lacosamide in a critically ill adult during continuous venovenous hemofiltration (CVVH). A 78-year-old male developed sepsis and acute kidney injury following cardiac surgery. He was initially treated with intermittent hemodialysis but developed nonconvulsive status epilepticus at the end of the first session and was subsequently initiated on CVVH. Read More

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October 2018
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Continuous Infusion Ampicillin for the Outpatient Management of Enterococcal Endocarditis: A Case Report and Literature Review.

J Pharm Pract 2018 Oct 16:897190018804964. Epub 2018 Oct 16.

3 Division of Infectious Diseases, Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine, Johnson, TN, USA.

Treatment of enterococcal endocarditis requires up to 6 weeks of intravenous (IV) antimicrobial therapy. When susceptible, an ampicillin-based regimen is preferred. Studies evaluating ampicillin stability utilizing high-pressure liquid chromatography have indicated enhanced stability (greater than 24 hours at room temperature), supporting outpatient administration. Read More

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http://dx.doi.org/10.1177/0897190018804964DOI Listing
October 2018
2 Reads

Improved Medication Management With Introduction of a Perioperative and Prescribing Pharmacist Service.

J Pharm Pract 2018 Oct 8:897190018804961. Epub 2018 Oct 8.

2 Department of Anaesthesia, Frankston Hospital, Peninsula Health, Frankston, Victoria, Australia.

Background: The medication lists in pre-admission clinic (PAC) questionnaires completed by patients prior to surgery are often inaccurate, potentially leading to medication errors during hospitalization. Studies have shown pharmacists are more accurate when obtaining a medication history and transcribing prescription orders, thereby reducing errors.

Objective: To evaluate the impact of a PeRiopErative and Prescribing (PREP) pharmacist on postoperative medication management. Read More

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October 2018
4 Reads

Characteristics of Mail-Order Pharmacy Users: Results From the Medical Expenditures Panel Survey.

Authors:
Junyi Ma Li Wang

J Pharm Pract 2018 Oct 2:897190018800188. Epub 2018 Oct 2.

2 Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.

Background: There is a paucity of research on the population characteristics of mail-order pharmacy users.

Objective: This study utilized a nationally representative sample to examine the characteristics of mail-order pharmacy users.

Methods: This study used data from the 2012 Medical Expenditure Panel Survey (MEPS). Read More

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October 2018
7 Reads

Carfilzomib Induced Tumor Lysis Syndrome and Other Adverse Events.

J Pharm Pract 2018 Oct 2:897190018802129. Epub 2018 Oct 2.

2 Department of Hematology and Oncology, Northwell Health Staten Island University Hospital, Staten Island, NY, USA.

In the area of multiple myeloma (MM) therapy, proteasome inhibitors (PI) have emerged with promising responses both in the first- and second-line setting. Carfilzomib (CFZ) is a second-generation, selective PI approved in 2012 for the treatment of relapsed/refractory multiple myeloma (RRMM) in patients who received 2 prior therapies or have evidence of disease progression within 60 days of completion of last therapy. Its safety profile reported adverse events (AEs) ranging from drug-related AEs (nausea and vomiting), hematologic AEs (neutropenia and thrombocytopenia), and nonhematologic AEs (electrolyte imbalances). Read More

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October 2018
2 Reads

Combined Insulin and GLP-1 Receptor Agonists: Simplifying Treatment or Adding Obstacles?

J Pharm Pract 2018 Oct 1:897190017753041. Epub 2018 Oct 1.

1 Department of Pharmacy, Houston Methodist Hospital, Houston, TX, USA.

The US Food and Drug Administration recently approved 2 combination products containing a basal insulin and a glucagon-like peptide 1 receptor agonist: insulin glargine/lixisenatide and insulin degludec/liraglutide. These agents were shown to be noninferior in lowering hemoglobin A compared to basal insulin and are indicated for patients inadequately controlled on basal insulin or glucagon-like peptide 1 receptor agonists alone. The clinical implications of these agents are unclear due to limitations in the clinical trials and limited recommendations in current guidelines. Read More

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http://dx.doi.org/10.1177/0897190017753041DOI Listing
October 2018
9 Reads

Risk of Nephrotoxicity Associated With Nonrenally Adjusted Intravenous Polymyxin B Compared to Traditional Dosing.

J Pharm Pract 2018 Sep 25:897190018799261. Epub 2018 Sep 25.

3 Infectious Disease, Department of Pharmacy, Long Island Jewish Medical Center, New Hyde Park, NY, USA.

Background: Polymyxin B's package insert recommends renal adjustment. Contemporary studies suggest it does not require renal adjustment.

Objective: To determine whether time to acute kidney injury (AKI) differs between renally adjusted and nonadjusted intravenous (IV) polymyxin B. Read More

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September 2018