4,549 results match your criteria Journal of Pharmacology[Journal]


Suppression of KCNQ/M Potassium Channel in Dorsal Root Ganglia Neurons Contributes to the Development of Osteoarthritic Pain.

Pharmacology 2019 Feb 13;103(5-6):257-262. Epub 2019 Feb 13.

Department of Orthopaedic Surgery, Institute of Biomechanical Science, Biomechanical Key Laboratory of Hebei Province, Third Hospital of Hebei Medical University, Shijiazhuang,

Osteoarthritic pain has a strong impact on patients' quality of life. Understanding the pathogenic mechanisms underlying osteoarthritic pain will likely lead to the development of more effective treatments. In the present study of osteoarthritic model rats, we observed a reduction of M-current density and a remarkable decrease in the levels of KCNQ2 and KCNQ3 proteins and mRNAs in dorsal root ganglia (DRG) neurons, which were associated with hyperalgesic behaviors. Read More

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http://dx.doi.org/10.1159/000496422DOI Listing
February 2019

Antifibrotic Agent Pirfenidone Suppresses Proliferation of Human Pancreatic Cancer Cells by Inducing G0/G1 Cell Cycle Arrest.

Pharmacology 2019 Feb 7;103(5-6):250-256. Epub 2019 Feb 7.

Department of Oncologic Pathology, Mie University, Tsu, Japan.

Background: Pirfenidone (PFD), which is an antifibrotic agent used for treatment of idiopathic pulmonary fibrosis, induces G0/G1 cell cycle arrest in fibroblasts. We hypothesized that PFD-induced G0/G1 cell cycle arrest might be achieved in other types of cells, including cancer cells. Here we investigated the effects of PFD on the proliferation of pancreatic cancer cells (PCCs) in vitro. Read More

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http://dx.doi.org/10.1159/000496831DOI Listing
February 2019

Probucol Slows the Progression of Cataracts in Streptozotocin-Induced Hyperglycemic Rats.

Pharmacology 2019 Feb 5;103(3-4):212-219. Epub 2019 Feb 5.

Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, Tokyo,

We examined the effect of probucol, an antihyperlipidemic drug with potent antioxidant properties, on cataract formation in streptozotocin (STZ)-induced hyperglycemic rats that were given 5% D-glucose as drinking water. Probucol treatment was initiated immediately after the induction of hyperglycemia was confirmed. Using full horizontal-plane lens images captured with an original digital camera system, the opacity of central region of lens was assessed by measuring the opaque area in the region. Read More

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http://dx.doi.org/10.1159/000496055DOI Listing
February 2019

Chronic Addiction to Tramadol and Withdrawal Effect on the Spermatogenesis and Testicular Tissues in Adult Male Albino Rats.

Pharmacology 2019 Jan 30;103(3-4):202-211. Epub 2019 Jan 30.

Department of Biology, College of Science, Majmaah University, Majmaah, Al-Zulfi, Saudi Arabia.

Aim: The present study aimed to elucidate the effects of tramadol on the testicular functions of adult male rats due to the chronic usage of tramadol and the effect of its withdrawal.

Method: Adult male albino rats were classified into the following 3 groups: (I) a control administered with normal saline and (II) tramadol-treated rats (40 mg/kg b.w. Read More

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http://dx.doi.org/10.1159/000496424DOI Listing
January 2019

Shenduning Granule Attenuates Renal Injury from Oxidative Stress through the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway.

Pharmacology 2019 Jan 30;103(5-6):236-245. Epub 2019 Jan 30.

Department of Nephropath, Jinhua Hospital of Traditional Chinese Medicine, Jinhua, China.

Background: Systemic oxidative stress has been reported to play a central role in the pathogenesis of kidney function decline. The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is one of the important endogenous antioxidant stress pathways in cells. This study aims to investigate whether shenduning granule can ameliorate oxidative stress in kidney tissues by activating the Nrf2/ARE pathway, and explores the detailed underlying mechanism. Read More

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http://dx.doi.org/10.1159/000494981DOI Listing
January 2019

Effect of Verapamil on Kidney Function Using Radionuclide Imaging.

Pharmacology 2019 Jan 29;103(3-4):173-178. Epub 2019 Jan 29.

Department of Biomedical Sciences, College of Nursing, Public Authority for Applied Education and Training, Kuwait, Kuwait.

Background And Objective: Calcium channel blockers (CCBs) are among the most widely used prescribed drugs for the treatment of cardiovascular diseases. The present study investigates the effect of verapamil, which is most commonly used as a CCB, on kidney function using radionuclide imaging.

Methods: Ten New Zealand white rabbits were used in vitro (4) and in vivo (6) studies. Read More

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http://dx.doi.org/10.1159/000495617DOI Listing
January 2019

Iron Chelation as Novel Treatment for Interstitial Cystitis.

Pharmacology 2019 Jan 29;103(3-4):159-162. Epub 2019 Jan 29.

Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia,

Interstitial cystitis (IC) is a highly prevalent debilitating disease, with its cardinal symptoms being severe pain, urinary urgency and frequency. The associated pain may eventually lead as a last resort to removal of the bladder. Though the initial trigger for IC remains largely unknown, we propose novel iron chelators as a possible new treatment for this disease. Read More

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http://dx.doi.org/10.1159/000496089DOI Listing
January 2019

Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens.

Pharmacology 2019 Jan 29;103(3-4):189-201. Epub 2019 Jan 29.

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi,

Background: A report examining whether clinically available antidepressants increase urethral smooth muscle contraction via antagonistic effects on the α2-adrenoceptor (α2-AR) is lacking.

Objectives: The present study was performed to evaluate the potential of clinically available antidepressants to reverse α2-AR-mediated contractile inhibition in rat vas deferens, in order to predict whether they can induce voiding impairment.

Method: The effects of 18 antidepressants of different classes on electrical field stimulation (EFS)-induced contractions suppressed by 10-8 mol/L clonidine (a selective α2-AR agonist) in isolated rat vas deferens were investigated and related to their respective clinical blood concentrations. Read More

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http://dx.doi.org/10.1159/000495616DOI Listing
January 2019

Impact of Different Pharmacotherapies on Long-Term Outcomes in Patients with Electrical Storm.

Pharmacology 2019 Jan 29;103(3-4):179-188. Epub 2019 Jan 29.

First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg/Mannheim, Mannheim, Germany.

Objective: The study sought to assess the long-term prognostic impact of different pharmacotherapies, including angiotensin-converting enzyme inhibitor-inhibitor/angiotensin receptor blocker (ACEi/ARB), statins, and amiodarone in patients with electrical storm (ES).

Background: Data regarding the outcome of patients with ES is limited.

Methods: Consecutive patients with ES from 2002 to 2016 were included. Read More

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http://dx.doi.org/10.1159/000496228DOI Listing
January 2019
1.581 Impact Factor

Osteoprotective Effect of Cimiracemate in Glucocorticoid-Induced Osteoporosis by Osteoprotegerin/Receptor Activator of Nuclear Factor κ B/Receptor Activator of Nuclear Factor Kappa-Β Ligand Signaling.

Pharmacology 2019 Jan 29;103(3-4):163-172. Epub 2019 Jan 29.

Department of Orthopedics, Tongren Hosptial, Shanghai Jiao Tong University School of Medicine, Shanghai,

Objectives: Present investigation determines the protective effect of cimiracemate A against glucocorticoid-induced osteoporosis rat.

Methods: Osteoporosis was induced by injecting methylprednisolone acetate (21 mg/kg) for the period of 6 weeks, and the rats were treated with cimiracemate A 5 and 10 mg/kg, p.o. Read More

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http://dx.doi.org/10.1159/000495509DOI Listing
January 2019
1 Read

Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages.

Pharmacology 2019 Jan 28;103(5-6):228-235. Epub 2019 Jan 28.

Department of the Second Anesthesia, Honghui Hospital, Xi 'an Jiaotong University, Xian,

The present manuscript intended to investigate the anti-inflammatory effect of ropivacaine on lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E2, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2. Read More

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http://dx.doi.org/10.1159/000496425DOI Listing
January 2019
1.581 Impact Factor

Panax Notoginseng Extract Possesses Significant Antibacterial Activity against Pathogenic Streptococci.

Pharmacology 2019 Jan 28;103(5-6):221-227. Epub 2019 Jan 28.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo,

Background: In traditional Chinese medicine, Panax notoginseng is used to treat inflammation and bleeding but has not been shown to affect bacterial pathogens.

Objectives: Our aim was to assess the antibacterial potential of Panax notoginseng extract (PNE) against bacterial pathogens.

Methods: PNE was dissolved in autoclaved distilled water. Read More

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http://dx.doi.org/10.1159/000496830DOI Listing
January 2019

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.

Pharmacology 2019 Jan 23;103(3-4):143-150. Epub 2019 Jan 23.

School of Food Science, Nanjing Xiaozhuang University, Nanjing, China.

Background: Ganoderma lucidum Polysaccharides (GLPS) were found to possess various pharmacological properties including anti-inflammatory and hepatoprotective activities. However, the effect and possible mechanism of GLPS treatment on liver injury have not yet been reported. Therefore, this study aimed to explore the potential anti-inflammatory and hepatoprotective effects and possible mechanism of GLPS in carbon tetrachloride (CCl4)-induced acute liver injury mice. Read More

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http://dx.doi.org/10.1159/000493896DOI Listing
January 2019
1 Read
1.581 Impact Factor

Blockade of Serotonin 2C Receptors with SB-242084 Moderates Reduced Locomotor Activity and Rearing by Cannabinoid 1 Receptor Antagonist AM-251.

Pharmacology 2019 Jan 23;103(3-4):151-158. Epub 2019 Jan 23.

Department of Pharmacodynamics, Semmelweis University, Budapest,

The endocannabinoid and serotonin (5-HT) systems have key roles in the regulation of several physiological functions such as motor activity and food intake but also in the development of psychiatric disorders. Here we tested the hypothesis, whether blockade of serotonin 2C (5-HT2C) receptors prevents the reduced locomotor activity and other behavioral effects caused by a cannabinoid 1 (CB1) receptor antagonist. As a pretreatment, we administered SB-242084 (1 mg/kg, ip. Read More

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http://dx.doi.org/10.1159/000495939DOI Listing
January 2019
1 Read

Tanshinone IIA Ameliorate Coxsackie Virus B3-Induced Viral Myocarditis through the Inhibition of Inflammation and Modulation T Helper 1/T Helper 2 Balance in Mice.

Pharmacology 2019 Jan 2;103(3-4):136-142. Epub 2019 Jan 2.

Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao,

To investigate the effect of Tanshinone IIA (TSA) on viral myocarditis (VMC). VMC animal model was established using BALB/c mice by intraperitoneally injecting Coxsackie virus B3 (CVB3). The mice were randomly divided into control group, model group, and TSA group. Read More

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https://www.karger.com/Article/FullText/495755
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http://dx.doi.org/10.1159/000495755DOI Listing
January 2019
7 Reads

In vitro Inhibitory Effects of Isofraxidin on Human Liver Cytochrome P450 Enzymes.

Pharmacology 2018 Dec 13;103(3-4):120-127. Epub 2018 Dec 13.

Isofraxidin is a Coumarin compound widely distributed in plants, such as the Umbelliferae or Chloranthaceae, and it possesses numerous pharmacological activities. However, whether isofraxidin affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear. In this study, the inhibitory effects of isofraxidin on the 8 human liver CYP isoforms (i. Read More

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http://dx.doi.org/10.1159/000495212DOI Listing
December 2018
1 Read

Ameliorative Effect of Withaferin A on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat.

Pharmacology 2018 Dec 13;103(3-4):114-119. Epub 2018 Dec 13.

Department of Anatomy, Velammal Medical College and Hospital, Madurai,

Withaferin A (WA) was evaluated for its neuro-protective efficacy on ageing induced striatal dopamine (DA) and behavioural changes in aged rats. Wistar albino rats were divided into group I - young (3 months), Group II - aged (24 months), Group III - aged rats supplemented with WA (50 mg/kg b.w once in a day for 30 days) and Group IV - young rats supplemented with WA (50 mg/kg b. Read More

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http://dx.doi.org/10.1159/000495510DOI Listing
December 2018
1 Read

Effective Ibuprofen Desensitization in a Patient with Myopericarditis.

Pharmacology 2018 Dec 13;103(3-4):111-113. Epub 2018 Dec 13.

Internal Medicine, Allergy Unit, Rimini Hospital, Azienda Sanitaria Romagna, Rimini, Italy.

To date, aspirin desensitization is employed with patients with nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbated respiratory diseases (NERD) or with aspirin or NSAIDs hypersensitive patients needing a stent procedure for coronary artery disease. On the other hand, few data exist regarding aspirin desensitization in other cardiological features and particularly we haven't data on different NSAIDs desensitization. Only for NERD patients we have data on ketorolac use. Read More

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https://www.karger.com/Article/FullText/495692
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http://dx.doi.org/10.1159/000495692DOI Listing
December 2018
4 Reads

Expression of Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and CD147 in the Traditional Chinese Medicine "Compound T11" for Treatment of Chronic Liver Injury.

Pharmacology 2018 Dec 13;103(3-4):128-135. Epub 2018 Dec 13.

First Clinical Medical School, Henan University of Chinese Medicine, Zhengzhou, China.

Objectives: To measure the expression of matrix metalloproteinase (MMP)-2, tissue inhibitor of matrix metalloproteinase inhibitor (TIMP)-2, and CD147 in mice with chronic liver injury induced by carbon tetrachloride after treatment with the traditional Chinese medicine (TCM) "Compound T11".

Method: Sixty male ICR mice were divided randomly into 6 groups of 10: control (C), model (M), low-dose treatment (LT; 50 mg/mL of Compound T11), medium-dose treatment (MT, 100 mg/mL), high-dose treatment (HT, 150 mg/mL), and positive drug treatment (YT, 67.5 mg/mL). Read More

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http://dx.doi.org/10.1159/000495141DOI Listing
December 2018
1 Read

Taxifolin Inhibits Receptor Activator of NF-κB Ligand-Induced Osteoclastogenesis of Human Bone Marrow-Derived Macrophages in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo.

Pharmacology 2019 6;103(1-2):101-109. Epub 2018 Dec 6.

Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha,

It has been reported that taxifolin inhibit osteoclastogenesis in RAW264.7 cells. In our research, the inhibition effects of taxifolin on the osteoclastogenesis of human bone marrow-derived macrophages (BMMs) induced by receptor activator of NF-κB ligand (RANKL) as well as the protection effects in lipopolysaccharide-induced bone lysis mouse model have been demonstrated. Read More

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https://www.karger.com/Article/FullText/495254
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http://dx.doi.org/10.1159/000495254DOI Listing
December 2018
12 Reads

Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress.

Pharmacology 2019 5;103(1-2):93-100. Epub 2018 Dec 5.

Department of Invasive Technology, Nantong First People's Hospital, The Second Affiliated Hospital of Nantong University, Nantong, China.

Depression is a mental disease that causes severe economic and social burdens. The mechanism for the onset of depression remains largely unknown. Recently, more and more attention is being given to the role of neuroinflammation and oxidative stress in depression. Read More

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http://dx.doi.org/10.1159/000494139DOI Listing
December 2018
3 Reads

Mechanisms of Etomidate-Mediated Decrease of Spontaneous Spike Activity of Mouse Cerebellar Purkinje Cells in vivo.

Pharmacology 2019 5;103(1-2):82-92. Epub 2018 Dec 5.

Key Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji,

Etomidate is an imidazole, nonbarbiturate hypnotic agent that is increasingly used in procedural sedation. However, the effects of etomidate on the spontaneous activity of cerebellar Purkinje cells (PCs) in living mouse have not been fully understood. In this study, we investigated the effects of etomidate on the spontaneous simple spike (SS) activity of PCs in urethane-anesthetized mice by cell-attached recording and pharmacological methods. Read More

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http://dx.doi.org/10.1159/000494980DOI Listing
December 2018
4 Reads

ErbB4 Receptors in the Medial Habenula Regulate Contextual Fear Memory.

Pharmacology 2019 4;103(1-2):68-75. Epub 2018 Dec 4.

Department of Pathophysiology, Zunyi Medical College, Zunyi, China.

The Medial Habenular (MHb) and the Lateral Habenular nuclei are 2 main parts of the habenular complex (Hb). Recent studies showed that MHb plays an important role in memory, and in the expression of ErbB4. However, the expression of MHb ErbB4 receptor and its role in fear memory is not well understood. Read More

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http://dx.doi.org/10.1159/000495064DOI Listing
December 2018
9 Reads

Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer's Disease in Transgenic Mice at Different Ages.

Pharmacology 2019 16;103(1-2):50-60. Epub 2018 Nov 16.

Department of Biomedical, Metabolic and Neural Sciences, Section of Pharmacology and Molecular Medicine, University of Modena and Reggio Emilia, Modena,

Backgroud: Alzheimer disease is an age-related severe neurodegenerative pathology. The level of the third endogenous gas, hydrogen sulfide (H2S), is decreased in the brain of Alzheimer's disease (AD) patients compared with the brain of the age-matched normal individuals; also, plasma H2S levels are negatively correlated with the severity of AD. Recently, we have demonstrated that systemic H2S injections are neuroprotective in an early phase of preclinical AD. Read More

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http://dx.doi.org/10.1159/000494113DOI Listing
November 2018
10 Reads

Propranolol Suppresses Cobalt Chloride-Induced Hypoxic Proliferation in Human Umbilical Vein Endothelial Cells in vitro.

Pharmacology 2019 16;103(1-2):61-67. Epub 2018 Nov 16.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing,

Background/aims: To investigate the effect of propranolol on cobalt chloride (CoCl2)-induced hypoxic proliferation in human umbilical vein endothelial cells (HUVECs).

Methods: CoCl2 was administrated to HUVECs to mimic hypoxic proliferation in infantile hemangioma. The proliferation of HUVECs was detected by Cell Counting Kit-8. Read More

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https://www.karger.com/Article/FullText/494762
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http://dx.doi.org/10.1159/000494762DOI Listing
November 2018
10 Reads
1.581 Impact Factor

Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of the Urotensin-II Receptor Antagonist Palosuran in Healthy Male Subjects.

Pharmacology 2018 1;102(5-6):339-346. Epub 2018 Nov 1.

Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.

Purpose: To investigate the multiple-dose pharmacokinetics (PK), pharmacodynamics (PD), and tolerability of palosuran, a selective, potent antagonist of the human UT receptor.

Methods: This was a double-blind, randomized, placebo-controlled study. Three dose levels were investigated for PKs, PDs, and safety in sequential groups of 8 subjects each. Read More

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https://www.karger.com/Article/FullText/492936
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http://dx.doi.org/10.1159/000492936DOI Listing
December 2018
6 Reads

Tetanic Facilitation of Neuromuscular Transmission by Adenosine A2A and Muscarinic M1 Receptors is Dependent on the Uptake of Choline via High-Affinity Transporters.

Pharmacology 2019 31;103(1-2):38-49. Epub 2018 Oct 31.

Department of Pharmacology and Therapeutic, State University of Maringá, Maringá,

Background/aims: In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A2A and muscarinic M1 receptors in the recovery of neuromuscular tetanic depression caused by the blockage of high-affinity choline transporter (HChT) by hemicholinium-3 (HC-3), a condition that mimics a myasthenia-like condition.

Methods: Rat diaphragm preparations were indirectly stimulated via the phrenic nerve trunk with 50-Hz frequency trains, each consisting of 500-750 supramaximal intensity pulses. The tension at the beginning (A) and at the end (B) of the tetanus was recorded and the ratio (R) B/A calculated. Read More

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https://www.karger.com/Article/FullText/494058
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http://dx.doi.org/10.1159/000494058DOI Listing
October 2018
5 Reads

Comparative Pharmacokinetic Study of Mangiferin in Normal and Alloxan-Induced Diabetic Rats after Oral and Intravenous Administration by UPLC-MS/MS.

Pharmacology 2019 25;103(1-2):30-37. Epub 2018 Oct 25.

Laboratory Animal Center, Chongqing Medical University, Chongqing,

Backgrounds: Diabetes mellitus (DM)-induced morphological and/or functional complications may alter the pharmacokinetic profiles of mangiferin. This study aims to compare pharmacokinetic profiles of mangiferin in normal and alloxan-induced diabetic rats after oral and intravenous administration.

Methods: Mangiferin was administered orally (10 mg/kg) and intravenously (2 mg/kg) to normal and alloxan-induced diabetic Sprague-Dawley (SD) rats (n = 8). Read More

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https://www.karger.com/Article/FullText/493364
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http://dx.doi.org/10.1159/000493364DOI Listing
October 2018
14 Reads

Prevention of Stent Thrombosis in Rats by a Direct Oral Factor Xa Inhibitor Edoxaban.

Pharmacology 2019 19;103(1-2):17-22. Epub 2018 Oct 19.

Rare Disease Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.

Background/aims: Stent thrombosis is a serious complication after percutaneous coronary intervention and femoropopliteal endovascular intervention. The aim of this study was to determine the antithrombotic effects of a direct factor Xa inhibitor edoxaban alone or in combination with antiplatelet agents in a rat model of stent thrombosis.

Methods: Stainless steel stents (4 stents per rat) were placed in an extracorporeal arteriovenous shunt. Read More

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https://www.karger.com/Article/FullText/494059
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http://dx.doi.org/10.1159/000494059DOI Listing
October 2018
14 Reads

Involvement of MicroRNA-133a in the Protective Effect of Hydrogen Sulfide against Ischemia/Reperfusion-Induced Endoplasmic Reticulum Stress and Cardiomyocyte Apoptosis.

Pharmacology 2019 16;103(1-2):1-9. Epub 2018 Oct 16.

Department of Cardiology, Bethune International Peace Hospital, Shijiazhuang,

Aim: Myocardial ischemia/reperfusion (I/R) injury is a severe trauma that cells undergo and is associated with cardiomyocyte apoptosis. Recently, miRNAs have been demonstrated to play an important role in cardiovascular biology and disease. However, whether the miR-133a and ER stress play a role in hydrogen sulfide (H2S) protection of cardiomyocytes against I/R-induced apoptosis remains unclear. Read More

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https://www.karger.com/Article/FullText/492969
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http://dx.doi.org/10.1159/000492969DOI Listing
October 2018
8 Reads
1.580 Impact Factor

Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats.

Pharmacology 2018 10;102(5-6):332-338. Epub 2018 Oct 10.

Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Republic of

This study examined the effects of intrathecal areca nut on spinal nerve-ligated and chemotherapy-induced neuropathic pain (NP), and investigated the relevance of spinal 5-hydroxytryptamine (5-HT) and α2-adrenergic receptors to those effects. For drug administration, intrathecal catheters were inserted into the subarachnoid space of male Sprague-Dawley rats. NP was induced either by spinal nerve ligation (left spinal nerves L5 and L6) or by chemotherapeutic injection (intraperitoneal cisplatin, 2 mg/kg/day, once daily for 4 days). Read More

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https://www.karger.com/Article/FullText/492394
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http://dx.doi.org/10.1159/000492394DOI Listing
December 2018
3 Reads

Structure-Activity Relationship of the GPR55 Antagonist, CID16020046.

Pharmacology 2018 8;102(5-6):324-331. Epub 2018 Oct 8.

Background/aims: CID16020046 blocks the effect of the lipid lysophosphatidylinositol (LPI) at its receptor, GPR55. CID16020046 and another antagonist, ML193, have been used to investigate GPR55-mediated effects of LPI on cells, tissues, and in vivo. Here we describe the structure-activity relationship of CID16020046. Read More

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https://www.karger.com/Article/FullText/493490
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http://dx.doi.org/10.1159/000493490DOI Listing
December 2018
3 Reads

The Anticancer Effect of Huaier Extract in Renal Cancer 786-O Cells.

Pharmacology 2018 8;102(5-6):316-323. Epub 2018 Oct 8.

Department of Urology, Qilu Hospital of Shandong University, Jinan,

Background: Trametes robiniophila Murr (Huaier) has been used as an adjuvant therapy of tumor in traditional Chinese medicine for many years, but the underlying mechanisms are largely unknown. In the present study, we tested the inhibitory effect of Huaier extract on renal cancer 786-O cells and explored the possible mechanisms.

Methods: 786-O cells were treated by gradient concentrations of Huaier extract, cell viability, invasion, migration and apoptosis were assessed by cell counting kit 8, cell scratch, transwell, and flow cytometry assay in vitro. Read More

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https://www.karger.com/Article/FullText/492935
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http://dx.doi.org/10.1159/000492935DOI Listing
December 2018
17 Reads

Ropivacaine Protects against Memory Impairment and Hippocampal Damage in a Rat Neurodegeneration Model.

Pharmacology 2018 26;102(5-6):307-315. Epub 2018 Sep 26.

Graduate Institute of Basic Medicine, New Taipei City,

Background: Ropivacaine, a long-acting amide local anesthetic agent, has been demonstrated to inhibit glutamatergic transmission. Glutamate neurotoxicity plays a pivotal role in the pathogenesis of brain disorders. The purpose of this study is to investigate the neuroprotective effect of ropivacaine against brain damage induced by kainic acid (KA), an analogue of glutamate. Read More

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http://dx.doi.org/10.1159/000493145DOI Listing
December 2018
1 Read

Nitrosonifedipine, a Photodegradation Product of Nifedipine, Suppresses Pharmacologically Induced Aortic Aneurysm Formation.

Pharmacology 2018 25;102(5-6):287-299. Epub 2018 Sep 25.

Department of Pharmacy, Tokushima University Hospital, Tokushima,

Background/aims: We have reported that nitrosonifedipine (NO-NIF), a photodegradation product of nifedipine, has strong antioxidant and endothelial protective effects, and can suppress several cardiovascular diseases in animal models. The objective of the present study was to investigate the effects of NO-NIF on aortic aneurysm formation.

Methods: The mice were infused with β-aminopropionitrile for 2 weeks and angiotensin II for 6 weeks to induce aortic aneurysm formation. Read More

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http://dx.doi.org/10.1159/000492577DOI Listing
December 2018
1 Read

Chronic Stress May Not Be a Factor in the Behavioral Response to Chronic Lithium in ICR Mice.

Pharmacology 2018 25;102(5-6):281-286. Epub 2018 Sep 25.

School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv,

Background: Lithium (Li) is the prototypic mood-stabilizing drug, but the individual response to Li is highly heterogeneous. Some evidence suggest interactions between Li and stress, and it is possible to hypothesize that lithium's effects are modified by stress conditions. The current study examines the interaction between 2 chronic stressors, constant light (CL) and restrain and the behavioral responses to chronic Li in female and male mice. Read More

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https://www.karger.com/Article/FullText/492717
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http://dx.doi.org/10.1159/000492717DOI Listing
December 2018
6 Reads

Attenuation of Remifentanil-Induced Hyperalgesia by Betulinic Acid Associates with Inhibiting Oxidative Stress and Inflammation in Spinal Dorsal Horn.

Pharmacology 2018 25;102(5-6):300-306. Epub 2018 Sep 25.

Department of Anesthesiology and Pain Clinic, The First Affiliated Hospital of Jiaxing University, Jiaxing,

Remifentanil-induced hyperalgesia (RIH) is known to be associated with oxidative stress and inflammation. Betulinic acid (BA) was reported to reduce visceral pain owing to its anti-oxidative and anti-inflammatory potential. Here, we -explored whether BA can attenuate RIH through inhibiting oxidative stress and inflammation in spinal dorsal horn. Read More

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https://www.karger.com/Article/FullText/493144
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http://dx.doi.org/10.1159/000493144DOI Listing
December 2018
7 Reads

MPT0B169 and MPT0B002, New Tubulin Inhibitors, Induce Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis in Human Colorectal Cancer Cells.

Pharmacology 2018 18;102(5-6):262-271. Epub 2018 Sep 18.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei,

We previously synthesized new tubulin inhibitors, MPT0B169 and MPT0B002, which induced growth inhibition and apoptosis in leukemia cells. However, their effects on solid tumor cells have not been determined. In this study, we investigated the effects of MPT0B169 and MPT0B002 on glioblastoma, breast, lung, and colorectal cancer (CRC) cell lines. Read More

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http://dx.doi.org/10.1159/000492494DOI Listing
December 2018
1 Read

Melatonin Induces Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing in a Rat Model of Femoral Fracture via Neuropeptide Y/Neuropeptide Y Receptor Y1 Signaling.

Pharmacology 2018 18;102(5-6):272-280. Epub 2018 Sep 18.

Graduate Training Base of Jinzhou Medical University, 463rd Hospital of PLA, Shenyang,

The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. Read More

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http://dx.doi.org/10.1159/000492576DOI Listing
December 2018
2 Reads

Sodium Houttuyfonate Inhibits Voltage-Gated Peak Sodium Current and Anemonia Sulcata Toxin II-Increased Late Sodium Current in Rabbit Ventricular Myocytes.

Pharmacology 2018 23;102(5-6):253-261. Epub 2018 Aug 23.

Cardio-Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan,

Aim: Sodium houttuyfonate (SH), a chemical compound originating from Houttuynia cordata, has been reported to have anti-inflammatory, antibacterial, and antifungal effects, as well as cardioprotective effects. In this study, we investigated the effects of SH on cardiac electrophysiology, because to the best of our knowledge, this issue has not been previously investigated.

Methods: We used the whole-cell patch-clamp technique to explore the effects of SH on peak sodium current (INa. Read More

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https://www.karger.com/Article/FullText/490465
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December 2018
18 Reads

A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase.

Pharmacology 2018 22;102(5-6):233-243. Epub 2018 Aug 22.

Department of Microbiology and Immunology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York, USA.

β-Tryptase is released from mast cells upon degranulation in response to allergic and inflammatory stimuli. Human tryptase is a homotetrameric serine protease with 4 identical active sites directed toward a central pore. These active sites present an optimized scenario for the rational design of bivalent inhibitors, which bridge 2 adjacent active sites. Read More

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https://www.karger.com/Article/FullText/492078
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http://dx.doi.org/10.1159/000492078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242772PMC
December 2018
10 Reads

Biochemical Properties of TAK-828F, a Potent and Selective Retinoid-Related Orphan Receptor Gamma t Inverse Agonist.

Pharmacology 2018 22;102(5-6):244-252. Epub 2018 Aug 22.

Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Japan.

Background/aims: Retinoid-related orphan receptor gamma t (RORγt) is a master regulator of T helper 17 cells that plays a pivotal role in the production of inflammatory cytokines including interleukin (IL)-17. Therefore, RORγt has attracted much attention as a target receptor for the treatment of inflammatory diseases including rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, and psoriasis. This study aims to characterize TAK-828F, a potent and selective RORγt inverse agonist. Read More

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https://www.karger.com/Article/FullText/492226
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http://dx.doi.org/10.1159/000492226DOI Listing
December 2018
11 Reads

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain.

Pharmacology 2018 10;102(3-4):223-232. Epub 2018 Aug 10.

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Nicotine is a stimulatory component in tobacco that activates the central nervous system reward pathway and causes nicotine dependence. We found that the anti-inflammatory agent, curcuminoid, prevents nicotine dependence and relapse, as assessed by the conditioned placed preference test. Curcuminoid (1, 3. Read More

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http://dx.doi.org/10.1159/000492154DOI Listing
November 2018
2 Reads

A pan-NADPH Oxidase Inhibitor Ameliorates Kidney Injury in Type 1 Diabetic Rats.

Pharmacology 2018 10;102(3-4):180-189. Epub 2018 Aug 10.

Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.

Background: NADPH oxidases (Nox) is a major enzyme system contributing to oxidative stress, which plays an important role in the pathogenesis of diabetic kidney disease (DKD). We have shown an elevation of renal Nox1, Nox2, and Nox4 in diabetic mice. APX-115, a pan-Nox inhibitor, attenuated the progression of DKD in mice. Read More

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https://www.karger.com/Article/FullText/491398
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http://dx.doi.org/10.1159/000491398DOI Listing
November 2018
22 Reads

MicroRNA-124 Prevents H2O2-Induced Apoptosis and Oxidative Stress in Human Lens Epithelial Cells via Inhibition of the NF-κB Signaling Pathway.

Authors:
Xiu-Li Gu

Pharmacology 2018 10;102(3-4):213-222. Epub 2018 Aug 10.

Aim: To investigate the regulation of microRNA-124 -(miRNA-124) on NF-κB pathway from H2O2-induced apoptosis and oxidative stress in human lens epithelial cells (hLEC).

Methods: The MTT (3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay was used to detect hLEC -viability. HLECs were divided into Blank, H2O2, mimics (miRNA-124 mimics) + H2O2, NC+ H2O2, pyrrolidine dithiocarbamate (PDTC; NF-κB signaling pathway inhibitor) + H2O2, and inhibitors (miRNA-124 inhibitors) + PDTC + H2O2 groups. Read More

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http://dx.doi.org/10.1159/000491433DOI Listing
November 2018
1 Read

γ-Acetylcholine Receptor Mediating Dynamic Changes of Resistance to Rocuronium in the Denervated Skeletal Muscle.

Pharmacology 2018 10;102(3-4):190-195. Epub 2018 Aug 10.

Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background/aims: Denervation resulted in resistance to non-depolarizing muscle relaxants (NDMRs), the magnitude of which changed after denervation in the skeletal muscle. The aim of this study was to investigate whether changed potencies of rocuronium were due to altered γ-acetylcholine receptor (γ-AChR) expression after skeletal muscle denervation.

Methods: Innervated and denervated muscle cells were used in this study. Read More

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http://dx.doi.org/10.1159/000490799DOI Listing
November 2018
4 Reads

11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor Development by Lentiviral Screening Based on Computational Modeling.

Pharmacology 2018 10;102(3-4):169-179. Epub 2018 Aug 10.

In this study, rat and human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) have been cloned by lentiviral transduction and expressed by CHO-K1 cells. The results showed that recombinant plasmids contained R11bhsd1 or H11bhsd1 have been constructed, which is consistent with the gene bank respectively. A clone cell was selected with G418 and cultivated to express 11β-HSD1. Read More

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http://dx.doi.org/10.1159/000491397DOI Listing
November 2018
20 Reads

Icariin Improves Sepsis-Induced Mortality and Acute Kidney Injury.

Pharmacology 2018 10;102(3-4):196-205. Epub 2018 Aug 10.

Department of Kidney Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objectives: Icariin (ICA) is a bioactive flavonoid with renal protective actions. This study investigated the effects of ICA on renal injury, inflammation, oxidative damage, apoptosis, and survival in a mouse model of cecal ligation and perforation (CLP)-induced sepsis.

Methods: Sepsis was induced by CLP. Read More

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http://dx.doi.org/10.1159/000487955DOI Listing
November 2018
8 Reads
1.580 Impact Factor

Once-a-Day Trazodone in the Treatment of Depression in Routine Clinical Practice.

Pharmacology 2018 10;102(3-4):206-212. Epub 2018 Aug 10.

Department of Psychology, Faculty of Arts, Masaryk University, Brno, Czech Republic.

Objective: The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice.

Methods: Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores > 21 and Clinical Global Impression - Severity (CGI/S) ≥4 were included in this post-authorization, non-interventional, observational prospective safety study, conducted in 8 psychiatric centers in the Czech -Republic. The acute treatment phase lasted 5 weeks: 1 week of titration and 4 weeks of full-dose treatment. Read More

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https://www.karger.com/Article/FullText/492079
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http://dx.doi.org/10.1159/000492079DOI Listing
November 2018
25 Reads

Unexpected Growth-Promoting Effect of Oxaliplatin in Excision Repair Cross-Complementation Group 1 Transfected Human Colon Cancer Cells.

Pharmacology 2018 26;102(3-4):161-168. Epub 2018 Jul 26.

Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.

The nucleotide excision repair protein excision repair cross-complementation group 1 (ERCC1) has been repeatedly shown to be involved in the sensitivity of cancer cells to platinum derivatives. In order to better understand this process, we transfected HCT-116 cells with a plasmid encoding ERCC1 and studied their in vitro and in vivo behaviour. No main differences were observed for sensitivity to platinum drugs, DNA repair capacity and clonogenicity in vitro. Read More

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http://dx.doi.org/10.1159/000491587DOI Listing
November 2018
12 Reads