2,631 results match your criteria Journal of Pharmacological Sciences[Journal]


Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake: A prospective, double blind, randomized trial in healthy volunteers.

J Pharmacol Sci 2019 Feb 1. Epub 2019 Feb 1.

Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

The aim of this study was to investigate the contribution of gene polymorphisms, in combination with habitual caffeine consumption, to the effect of caffeine intake on hemodynamic and psychoactive parameters. A double-blind, prospective study was conducted with 201 healthy volunteers randomly allocated 2:1 to the caffeinated group (150 mL decaffeinated coffee with additional 200 mg caffeine) or decaffeinated group (150 mL decaffeinated coffee). We measured the changes in blood pressure (BP) and calculation speed upon coffee intake, stratifying with gene polymorphisms, e. Read More

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http://dx.doi.org/10.1016/j.jphs.2019.01.006DOI Listing
February 2019

Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis.

J Pharmacol Sci 2019 Feb 2. Epub 2019 Feb 2.

Department of Pharmacy, School of Life and Health Science, Anhui Science and Technology University, Fengyang, Anhui, People's Republic of China. Electronic address:

Objectives: The therapeutic potentiality of Bazhengsan on the chronic nonbacterial prostatitis was investigated.

Methods: Prostatitis was induced by subcutaneous injection of the 17-beta-estradiol (E) and dihydrotestosterone in male rat, and treated with Bazhengsan. After 8 weeks, prostatic fluid was collected for counting lecithin corpuscle density (LCD) and the organs were removed from animals and used for measuring prostate viscera coefficient (PVC). Read More

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http://dx.doi.org/10.1016/j.jphs.2019.01.007DOI Listing
February 2019
1 Read

The effect of honokiol on pulmonary artery endothelium cell autophagy mediated by cyclophilin A in hypoxic pulmonary arterial hypertension.

J Pharmacol Sci 2019 Feb 1. Epub 2019 Feb 1.

Department of Pharmaceutical Analysis and Analytical Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang Province, China. Electronic address:

Abnormal autophagy plays critical roles in the structure and function of the pulmonary vasculature. Cyclophilin A (CyPA) can be secreted from cells in response to hypoxia and oxidative stress, which are involved in inducing autophagy and regulating the function of endothelial cells in pulmonary arterial hypertension. Honokiol is a small molecule natural compound; it has many bioactivities, such as antitumor, anti-inflammatory, antioxidant and antiangiogenic properties, but how honokiol mediates autophagy in pulmonary arterial hypertension is unclear. Read More

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http://dx.doi.org/10.1016/j.jphs.2019.01.005DOI Listing
February 2019

Electropharmacological effects of intracellular Ca handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs.

J Pharmacol Sci 2019 Jan 24. Epub 2019 Jan 24.

Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan; Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.

We analyzed how the enhancement of net sarcoplasmic reticulum (SR) Ca uptake may affect cardiac electrophysiological properties in vivo by using caldaret which can decrease SR diastolic Ca leak, enhance SR Ca reuptake and inhibit reverse-mode Na/Ca exchanger. Caldaret in doses of 0.5, 5 and 50 μg/kg was intravenously administered over 10 min to the halothane-anesthetized beagle dogs (n = 5), attaining pharmacologically active plasma concentration. Read More

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http://dx.doi.org/10.1016/j.jphs.2019.01.004DOI Listing
January 2019
2 Reads

Coumarins ameliorate diabetogenic action of dexamethasone via Akt activation and AMPK signaling in skeletal muscle.

J Pharmacol Sci 2019 Jan 23. Epub 2019 Jan 23.

Institute of Pharmacology, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China; Section of Endocrinology, School of Medicine, Yale University, New Haven 06520, USA. Electronic address:

Glucocorticoids are widely prescribed for lots of pathological conditions, however, can produce 'Cushingoid' side effects including central obesity, glucose intolerance, insulin resistance and so forth. Our study is intended to investigate the improving effects of coumarins on diabetogenic action of dexamethasone in vivo and in vitro and elucidate potential mechanisms. ICR mice treated with dexamethasone for 21 days exhibited decreased body weight, increased blood glucose and impaired glucose tolerance, which were prevented by fraxetin (40 mg/kg/day), esculin (40 mg/kg/day) and osthole (20 mg/kg/day), respectively. Read More

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http://dx.doi.org/10.1016/j.jphs.2019.01.001DOI Listing
January 2019
2 Reads

Fetal neural stem cells from a mouse model of 15q11-13 duplication syndrome exhibit altered differentiation into neurons and astrocytes.

J Pharmacol Sci 2018 Dec 28. Epub 2018 Dec 28.

Department of Pharmacology, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea; Seoul National University Bundang Hospital, Seongnam, 463-707, South Korea; Neuroscience Research Institute, College of Medicine, Seoul National University, 103 Daehakro, Jongro-gu, Seoul, 110-799, Republic of Korea. Electronic address:

The duplication of human chromosome 15q11-13 is known to be associated with an estimated 1.1% of autism cases. Here, we investigated whether differentiation into neurons and astrocytes is altered in fetal neural stem cells (FNSCs) isolated from the mouse model of 15q11-13 duplication syndrome (patDp/+ mice). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.12.007DOI Listing
December 2018
1 Read

Qingnao dripping pills mediate immune-inflammatory response and MAPK signaling pathway after acute ischemic stroke in rats.

J Pharmacol Sci 2019 Jan 22. Epub 2019 Jan 22.

Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, 6 Zone One of Fangxingyuan, Fang Zhuang, Feng Tai District, Beijing, 100078, China. Electronic address:

The aim of the present study was to examine the neuroprotective effect of Qingnao dripping pills (QNDP), especially the infiltration of neutrophils and macrophages, as well as the mitogen-activated protein kinase (MAPK) signal pathway. Adult male Sprague-Dawley rats were randomized to three groups: sham, MCAO, and QNDP. After 24 h of ischemia and reperfusion, neurological deficit scores and infarct volume were measured. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.12.009DOI Listing
January 2019
2.360 Impact Factor

Oxyresveratrol protects human lens epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis by activation of Akt/HO-1 pathway.

J Pharmacol Sci 2019 Jan 22. Epub 2019 Jan 22.

Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China.

Oxidative stress induced by hydrogen peroxide (HO) triggers human lens epithelial cell (HLEC) apoptosis and initiates cataract formation. Oxyresveratrol (Oxy) was reported to possess antioxidant and free radical scavenging activities. Herein, we investigated the effects of Oxy on HO-induced oxidative stress and apoptosis in HLECs and the associated mechanisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613193000
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http://dx.doi.org/10.1016/j.jphs.2019.01.003DOI Listing
January 2019
3 Reads

Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats.

J Pharmacol Sci 2019 Jan 17. Epub 2019 Jan 17.

Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashimachi, Kodaira, Tokyo 187-8553, Japan. Electronic address:

Strategies to facilitate extinction of fear memory have attracted increasing attention for enhancing the effectiveness of exposure therapy for anxiety disorders. Previously, we demonstrated that systemic administration of a delta opioid receptor agonist, KNT-127, has clear anxiolytic-like effects in rats, without impairing memory. These observations led us to hypothesize that KNT-127 might be an appropriate therapeutic agent for anxiety disorders when combined with exposure therapy. Read More

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http://dx.doi.org/10.1016/j.jphs.2019.01.002DOI Listing
January 2019

Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats.

J Pharmacol Sci 2018 Dec 31. Epub 2018 Dec 31.

Laboratory of Clinical Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-kita, Tondabayashi, Osaka, 584-8540, Japan.

Ischemia/reperfusion injury is the most common cause of acute kidney injury. We previously revealed that pre-treatment with yohimbine or JP-1302 attenuated renal ischemia/reperfusion injury by inhibition of α2C-adrenoceptor antagonist. The aim of the present study is to investigate the effects of post-treatment with JP-1302 on renal ischemia/reperfusion injury in rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183023
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http://dx.doi.org/10.1016/j.jphs.2018.12.008DOI Listing
December 2018
5 Reads

Chotosan ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia via activating the Nrf2-mediated antioxidant pathway.

J Pharmacol Sci 2019 Feb 22;139(2):105-111. Epub 2018 Dec 22.

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of China; Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing, 211198, People's Republic of China. Electronic address:

Recent studies suggested that Chotosan has ameliorative effects on vascular dementia through antioxidative pathways. Nevertheless, no systematic pharmacological research was conducted to evaluate the contribution of nuclear factor-E2-related factor 2 (Nrf2), a crucial regulator of antioxidative system, on Chotosan-induced neuroprotection invascular dementia. The present study aimed to investigate the neuroprotective effect of Chotosan on vascular dementia and reveal the possible molecular mechanism involving Nrf2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183022
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http://dx.doi.org/10.1016/j.jphs.2018.12.003DOI Listing
February 2019
4 Reads

Probucol ameliorates hepatic stellate cell activation and autophagy is associated with farnesoid X receptor.

J Pharmacol Sci 2019 Feb 21;139(2):120-128. Epub 2018 Dec 21.

Department of Pharmacology, College of Medicine and Health, Lishui University, Lishui, 323000, China. Electronic address:

Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the role of FXR in this progress were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183022
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http://dx.doi.org/10.1016/j.jphs.2018.12.005DOI Listing
February 2019
2 Reads

A dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates cardiac dysfunction after myocardial infarction independently of DPP-4.

J Pharmacol Sci 2019 Feb 18;139(2):112-119. Epub 2018 Dec 18.

Department of Pharmacology, Osaka City University Graduate School of Medicine, Osaka, Japan; Department of Internal Medicine, Takaishikamo Hospital, Osaka, Japan. Electronic address:

Dipeptidyl peptidase-4 (DPP-4) inhibitors not only improve impaired glucose tolerance in diabetes, but also have pleiotropic extra-pancreatic effects such as preconditioning effect for myocardial ischemia-reperfusion injury. Here, we investigated the anti-remodeling effects of linagliptin, a DPP-4 inhibitor, by use of DPP-4-deficient rats. After the induction of myocardial infarction (MI), Fischer 344 rats with inactivating mutation of DPP-4 were orally administrated with a DPP-4 inhibitor, linagliptin (5 mg kg·day), or vehicle in drinking water for 4 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183022
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http://dx.doi.org/10.1016/j.jphs.2018.12.004DOI Listing
February 2019
2 Reads

5-HT deletion protects against Clozapine-induced hyperglycemia.

J Pharmacol Sci 2019 Feb 18;139(2):133-135. Epub 2018 Dec 18.

National Centre for Biological Sciences, TIFR, GKVK Campus, Bellary Road, Bengaluru, India; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA. Electronic address:

Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.015DOI Listing
February 2019
1 Read

Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels.

J Pharmacol Sci 2019 Feb 18;139(2):51-58. Epub 2018 Dec 18.

Institute of Pharmacology and Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Low-threshold Ca spikes are mediated by T-type Ca channels, which have electrophysiological properties of fast inactivation and slow deactivation kinetics. A low membrane potential of approximately -60 mV is sufficient to trigger channel opening. We recently introduced a novel T-type Ca channel enhancer that improves cognition and inhibits amyloid beta aggregation in an Alzheimer's disease (AD) mouse model. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.014DOI Listing
February 2019

Fibroblast growth factor 2 modulates extracellular purine metabolism by upregulating ecto-5'-nucleotidase and adenosine deaminase in cultured rat spinal cord astrocytes.

J Pharmacol Sci 2019 Feb 14;139(2):98-104. Epub 2018 Dec 14.

Laboratory of Pharmacology, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo 060-0818, Japan. Electronic address:

Purinergic signaling via ATP and adenosine produced by astrocytes is one pathway underlying neuron-glia interactions in the central nervous system (CNS). In production of purines, extracellular metabolism of released purines via ecto-enzymes is important. The expression and activities of these enzymes are altered under pathological conditions. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.12.002DOI Listing
February 2019

Daphnetin inhibits high glucose-induced extracellular matrix accumulation, oxidative stress and inflammation in human glomerular mesangial cells.

J Pharmacol Sci 2019 Feb 7;139(2):91-97. Epub 2018 Dec 7.

Department of Nephrology, Xinxiang Central Hospital, Xinxiang 453000, Henan, China.

Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease (ESRD). Oxidative stress and inflammation have been documented to play important roles in the pathogenesis of DN. Daphnetin, a natural coumarin compound, possesses antioxidant and anti-inflammatory activities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183021
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http://dx.doi.org/10.1016/j.jphs.2018.11.013DOI Listing
February 2019
2 Reads

A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain.

J Pharmacol Sci 2019 Feb 10;139(2):59-64. Epub 2018 Dec 10.

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35-1, Towada City, Aomori 034-8628, Japan.

Type IV collagen is a main component of basement membrane extracellular matrix. Canstatin, a non-collagenous C-terminal fragment of type IV collagen α2 chain, was firstly identified as an endogenous anti-angiogenic and anti-tumor factor, which also has an anti-lymphangiogenic effect. Then, canstatin has been widely investigated as a novel target molecule for cancer therapy. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.12.001DOI Listing
February 2019

Carteolol hydrochloride reduces visible light-induced retinal damage in vivo and BSO/glutamate-induced oxidative stress in vitro.

J Pharmacol Sci 2019 Feb 6;139(2):84-90. Epub 2018 Dec 6.

Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan. Electronic address:

The purpose of this study was to determine whether carteolol eye drops, a β-adrenoceptor antagonist used as an intraocular hypotensive agent, has protective effects against the light-induced oxidative stress in retina. Dark-adapted pigmented rats were pre-treated with topical carteolol ophthalmic solution or saline and then exposed to visible light. The effects on electroretinogram (ERG), morphology, oxidative stress, and expression of mRNAs in the retinas were determined. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.010DOI Listing
February 2019
1 Read

Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats.

J Pharmacol Sci 2019 Feb 30;139(2):77-83. Epub 2018 Nov 30.

Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Nankoku, Kochi, Japan.

The beneficial effects of physical activity for pain are denominated exercise-induced hypoalgesia (EIH). Here, we examined the age-related change and potential role of the neurosteroid allopregnanolone (ALLO) on EIH in rats. Adult and aged rats were randomly divided into one of three groups; non-exercise control, Low-exercise, and High-exercise. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.009DOI Listing
February 2019
1 Read

Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens.

J Pharmacol Sci 2019 Feb 11;139(2):65-71. Epub 2018 Dec 11.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefore, we carried out a study to determine the pharmacokinetics of tacrolimus after intramuscular (IM) injection and to determine the optimal IM dosing regimens in primate models. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.05.013DOI Listing
February 2019

PPARγ overexpression regulates cholesterol metabolism in human L02 hepatocytes.

J Pharmacol Sci 2019 Jan 30;139(1):1-8. Epub 2018 Nov 30.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, Jiangsu, China. Electronic address:

Peroxisome proliferator-activator receptor (PPAR) γ is a nuclear hormone receptor that regulates glucose homeostasis, lipid metabolism, and adipocyte function. It has been shown that activation of PPARγ can reduce the incidence of gallstone. Herein we aimed to clarify the role of PPARγ in the reduction of gallstones. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183021
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http://dx.doi.org/10.1016/j.jphs.2018.09.013DOI Listing
January 2019
2 Reads

The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice.

J Pharmacol Sci 2019 Feb 1;139(2):129-132. Epub 2018 Dec 1.

Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

We recently developed PA-8, a novel small-molecule antagonist of PACAP type 1 (PAC1) receptor. In the present study, we examined whether PA-8 was effective against formalin-induced inflammatory pain in mice. Both intrathecal and oral administration of PA-8 resulted in the dose-dependent attenuation of the second phase of formalin-induced nociceptive responses. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.011DOI Listing
February 2019
10 Reads

Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice.

J Pharmacol Sci 2019 Feb 30;139(2):72-76. Epub 2018 Nov 30.

Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address:

Kamiuntanto (KUT; Jia Wei Wen Dan Tang in Pinyin) is a traditional Japanese Kampo medicine that is used to treat psychological dysfunction. However, the mechanisms of action of KUT are not understood. To investigate the mechanisms underlying the ameliorative properties of KUT, the effects of KUT on abnormal behaviors of isolation-reared mice and on the prefrontal monoaminergic system were examined. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.008DOI Listing
February 2019

Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome.

J Pharmacol Sci 2019 Jan 24;139(1):46-49. Epub 2018 Nov 24.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan; Department of General Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan.

Visceral hypersensitivity and impaired gut barrier with minor inflammation are considered to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Since pioglitazone is known to have anti-inflammatory property, we hypothesized that pioglitazone is beneficial for treating IBS. In this study, the effect was tested in rat IBS models such as lipopolysaccharide or repeated water avoidance stress-induced visceral allodynia and increased colonic permeability. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.006DOI Listing
January 2019
1 Read

SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism.

J Pharmacol Sci 2019 Jan 24;139(1):29-36. Epub 2018 Nov 24.

Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kausmi, Minami-ku, Hiroshima 734-8551, Japan. Electronic address:

The serotonin transporter (SERT) is functionally regulated via membrane trafficking. Our previous studies have demonstrated that the SERT C-terminal deletion mutant (SERTΔCT) showed a robust decrease in its membrane trafficking and was retained in the endoplasmic reticulum (ER), suggesting that SERTΔCT is an unfolded protein that may cause ER stress. The Sigma-1 receptor (SigR1) has been reported to attenuate ER stress via its chaperone activity. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.005DOI Listing
January 2019

The influence of telmisartan on metformin pharmacokinetics and pharmacodynamics.

J Pharmacol Sci 2019 Jan 25;139(1):37-41. Epub 2018 Nov 25.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China. Electronic address:

Metformin is the most widely used drug among type 2 diabetes mellitus patients. However, drug interaction on metformin will influence its glucose-lowering effect or increase its side effect of lactic acidosis. In this study, a randomized, two-stage, crossover study was conducted to unveil the potential drug interaction between metformin and the anti-hypertension drug, telmisartan. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.007DOI Listing
January 2019
3 Reads
2.360 Impact Factor

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart.

J Pharmacol Sci 2019 Jan 24;139(1):23-28. Epub 2018 Nov 24.

International Clinical Research Center, St. Anne's Faculty Hospital, Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183020
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http://dx.doi.org/10.1016/j.jphs.2018.11.004DOI Listing
January 2019
2 Reads

Physiological role of nitric oxide for regulation of arterial stiffness in anesthetized rabbits.

J Pharmacol Sci 2019 Jan 24;139(1):42-45. Epub 2018 Nov 24.

Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan. Electronic address:

We assessed effects of acetylcholine and Nω-Nitro-l-arginine methyl ester hydrochloride (l-NAME) on the cardio-ankle vascular index (CAVI), an indicator of arterial stiffness from origin of aorta to tibial artery, in halothane-anesthetized rabbits. Acetylcholine decreased the blood pressure, femoral vascular resistance and CAVI, whereas l-NAME did not affect the CAVI at a hypertensive dose. The acetylcholine-induced decrement of CAVI was completely suppressed by l-NAME. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.003DOI Listing
January 2019
3 Reads

Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells.

J Pharmacol Sci 2019 Jan 25;139(1):15-22. Epub 2018 Nov 25.

Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Integrative & Optimized Medicine Research Center, China-USA Institute for Acupuncture and Rehabilitation, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Background: Neuroinflammation plays a major role in the development of ischemic stroke, and regulation of the proinflammatory TLR4 signaling pathway in microglia stands to be a promising therapeutic strategy for stroke intervention. Recently, the homeostasis of mitochondrial dynamics has also been raised as a vital component in maintaining neuronal health, but its relevance in microglia hasn't been investigated. Schaftoside, a natural flavonoid compound and a promising treatment for inflammation, has demonstrated potency against LPS-induced lung inflammation in mice; however, its action on TLR4-induced neuroinflammation and mitochondrial dynamics in microglia is still unknown. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.012DOI Listing
January 2019
10 Reads

Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection.

J Pharmacol Sci 2018 Dec 25;138(4):247-256. Epub 2018 Jun 25.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China. Electronic address:

Dengue virus (DENV) annually infects 400 million people worldwide. Unfortunately, there is lack of widely protective vaccine or drugs against DENV. The viral RNA-dependent RNA polymerase (RdRp) of NS5 protein is highly conserved among different DENV subtypes, thus presenting itself as an attractive target for drug design. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.06.012DOI Listing
December 2018
11 Reads
2.360 Impact Factor

Long-term efficacy and safety profile of multiple injections of intravitreal dexamethasone implant to manage diabetic macular edema: A systematic review of real-world studies.

J Pharmacol Sci 2018 Dec 20;138(4):219-232. Epub 2018 Nov 20.

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy; Center for Research in Ocular Pharmacology, CERFO University of Catania, Catania, Italy; Regional Pharmacovigilance Centre of Catania, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy.

Introduction: Systematic review of real-world studies about repeated dexamethasone intravitreal implant (DEXi) 0.7 mg in diabetic macular edema management, in order to identify the effective window of time occurring between injections, the critical evaluation of efficacy of the treatment, and the relative long-term safety in the real life setting.

Methods: Literature databases such as PubMed, SCOPUS, and EMBASE were used to identify reports including DEX implant injections. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.001DOI Listing
December 2018
1 Read

Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression.

J Pharmacol Sci 2018 Dec 20;138(4):284-288. Epub 2018 Nov 20.

Division of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, Japan. Electronic address:

Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its effect on imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice. We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.002DOI Listing
December 2018

Activation of c-Jun N-terminal kinase and p38 after cerebral ischemia upregulates cerebral sodium-glucose transporter type 1.

J Pharmacol Sci 2018 Dec 7;138(4):240-246. Epub 2018 Nov 7.

Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe 650-8586, Japan. Electronic address:

Cerebral ischemic stress increases cerebral sodium-glucose transporter type 1 (SGLT-1). However, the mechanism by which cerebral ischemia leads to the up-regulation of SGLT-1 remains unclear. In peripheral tissue, the activation of mitogen-activated protein kinases (MAPKs) increases SGLT-1. Read More

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http://dx.doi.org/10.1016/j.jphs.2017.02.016DOI Listing
December 2018

Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model.

J Pharmacol Sci 2018 Dec 2;138(4):257-262. Epub 2018 Oct 2.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Cichorium glandulosum Boiss. et Huet (CG) is a common traditional Uighur medicine, and it has been widely used as active therapy on various hepatic diseases. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.012DOI Listing
December 2018

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis.

J Pharmacol Sci 2018 Dec 23;138(4):263-270. Epub 2018 Oct 23.

Department of Orthopedic, Guizhou Provincial People's Hospital, Guizhou, 550002, China. Electronic address:

Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration. However, the role of miR-532 in intervertebral disc degeneration remains unclear. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.007DOI Listing
December 2018
1 Read

Protocatechuic acid inhibits TGF-β1-induced proliferation and migration of human airway smooth muscle cells.

J Pharmacol Sci 2019 Jan 5;139(1):9-14. Epub 2018 Nov 5.

Department of Pediatrics, Xijing Hospital, The Fourth Military Medial University, Xi'an, Shaanxi, PR China.

Protocatechuic acid (3, 4-dihydroxybenzoic acid, PCA) is a major metabolite of anthocyanins and was reported to possess anti-allergic response. However, the effects of PCA on airway smooth muscle cells (ASMCs) proliferation and migration remain unclear. Therefore, this study aims to investigate the effects of PCA on proliferation and migration of ASMCs. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.011DOI Listing
January 2019
2 Reads

Inhibitory effects of Kampo medicines, Keishibukuryogan and Shakuyakukanzoto, on the substrate uptake activities of solute carrier organic anion transporters.

J Pharmacol Sci 2018 Dec 24;138(4):279-283. Epub 2018 Oct 24.

The K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea. Electronic address:

The aim of this study was to assess the effects of Keishibukuryogan (K-06) and Shakuyakukanzoto (TJ-68), commercial herbal medicines, on the substrate uptake activities of renal organic anion transporters. We performed transporter uptake and cell viability assays in Xenopus oocytes and HEK293 human kidney embryonic cells treated with K-06 or TJ-68. K-06 and TJ-68 markedly inhibited the substrate uptake activities of URAT1, OAT1, and OAT3, while they did not exhibit non-cytotoxic effects. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.008DOI Listing
December 2018
8 Reads

SBF-1 preferentially inhibits growth of highly malignant human liposarcoma cells.

J Pharmacol Sci 2018 Dec 24;138(4):271-278. Epub 2018 Oct 24.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. Electronic address:

Frequent local recurrence and metastasis are generally involved in human liposarcoma, but the management is a challenge. There is an urgent need for improved effective therapy. In the present study, we reported that SBF-1, a steroidal glycoside, inhibited the growth of cultured highly malignant human liposarcoma SW872-S cells in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.009DOI Listing
December 2018
9 Reads
2.360 Impact Factor

Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update.

J Pharmacol Sci 2018 Dec 24;138(4):233-239. Epub 2018 Oct 24.

Japan iPS Cardiac Safety Assessment (JiCSA), Japan; The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Cardiac safety assessment is challenging because a better understanding of torsadogenic mechanisms beyond hERG blockade and QT interval prolongation is necessary for patient safety. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a new human cell-based platform to assess cardiac safety in non-clinical testing during drug development. The multi-electrode array (MEA) platform is a promising electrophysiological technology to assess QT interval prolongation and proarrhythmic potential of drug candidates using hiPSC-CMs. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.010DOI Listing
December 2018
1 Read

Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats.

J Pharmacol Sci 2018 Nov 26;138(3):214-217. Epub 2018 Oct 26.

Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.

Oxaliplatin causes acute cold hypersensitivity in most patients. We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats. In this study, we examined the effect of riluzole on oxaliplatin-induced cold allodynia. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.006DOI Listing
November 2018
9 Reads

Anti-angiogenic effects of valproic acid in a mouse model of oxygen-induced retinopathy.

J Pharmacol Sci 2018 Nov 14;138(3):203-208. Epub 2018 Oct 14.

Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Pathological retinal angiogenesis contributes to the pathogenesis of several ocular diseases. Valproic acid, a widely used antiepileptic drug, exerts anti-angiogenic effects by inhibiting histone deacetylase (HDAC). Herein, we investigated the effects of valproic acid and vorinostat, a HDAC inhibitor, on pathological retinal angiogenesis in mice with oxygen-induced retinopathy (OIR). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.004DOI Listing
November 2018
7 Reads

Water-extracted branch of Cinnamomum cassia promotes lung cancer cell apoptosis by inhibiting pyruvate dehydrogenase kinase activity.

J Pharmacol Sci 2018 Oct 18;138(2):146-154. Epub 2018 Oct 18.

Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Busandaehak-ro 49, Yangsan, Gyeongnam 50612, Republic of Korea; Healthy Aging Korean Medical Research Center, Pusan National University, Busandaehak-ro 49, Yangsan, Gyeongnam 50612, Republic of Korea; Graduate Training Program of Korean Medicine for Healthy-aging, Pusan National University, Busandaehak-ro 49, Yangsan, Gyeongnam 50612, Republic of Korea. Electronic address:

Cinnamomum cassia Blume has been widely reported as the anti-tumor agent. However, the precise mechanism underlying its pro-apoptotic action is still not clear. Restraining aerobic glycolysis through suppression of pyruvate dehydrogenase kinase (PDHK) is a promising strategy for cancer inhibition. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.005DOI Listing
October 2018
11 Reads

Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death.

J Pharmacol Sci 2018 Nov 17;138(3):198-202. Epub 2018 Oct 17.

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. Electronic address:

Although azithromycin can suppress cardiac I, I, I, I and I, its onset mechanisms for cardiovascular death have not been fully investigated. We examined electropharmacological effects of azithromycin in intravenous doses of 0.3, 3 and 30 mg/kg using microminipigs under the halothane anesthesia (n = 4), which provided plasma concentrations of 3. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.003DOI Listing
November 2018
13 Reads

Maslinic acid protects against pressure overload-induced cardiac hypertrophy in mice.

J Pharmacol Sci 2018 Oct 14;138(2):116-122. Epub 2018 Oct 14.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China. Electronic address:

Cardiac hypertrophy is characterized by myocyte hypertrophy, accumulation of cardiac collagen, and reactivation of fetal genes. Maslinic acid (MA) is a pentacyclic triterpene with abundance in olive fruit skin and possesses a number of pharmacological actions. However, its effect on pressure overload-induced cardiac hypertrophy remains unknown. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.014DOI Listing
October 2018
1 Read

Dual effect of polyphosphate on mineralization of rat osteoblast ROS17/2.8 cells in a dose-dependent manner.

J Pharmacol Sci 2018 Nov 13;138(3):209-213. Epub 2018 Oct 13.

Department of Biochemistry, Nihon University School of Dentistry, 1-8-13 Kanda Surugadai Chiyoda-ku, Tokyo 101-8310, Japan. Electronic address:

Inorganic polyphosphate (polyP), a linear polymer of orthophosphate, is found at high concentrations in osteoblasts. We demonstrated the effects of various polyP concentrations on the mineralization of rat osteoblast ROS17/2.8 cells. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.002DOI Listing
November 2018

A Rho-kinase inhibitor reverses learning and memory deficits in a Rat model of chronic cerebral ischemia by altering Bcl-2/Bax-NMDAR signaling in the cerebral cortex.

J Pharmacol Sci 2018 Oct 22;138(2):107-115. Epub 2018 Sep 22.

Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai, 200080, PR China. Electronic address:

The current study investigated whether a Rho-kinase inhibitor alleviated impairments in a rat model of chronic cerebral ischemia and examined the specific pathological mechanisms by which Rho-kinase impacts neuronal damage and cognitive dysfunction. Adult Sprague-Dawley rats underwent permanent bilateral carotid artery occlusion (BCAO) to establish our chronic cerebral ischemia model. Chronic Y27632 administration reversed the abnormal behaviors of BCAO-treated rats in the Morris water maze. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.012DOI Listing
October 2018
8 Reads

Involvement of 5-HT receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats.

J Pharmacol Sci 2018 Nov 9;138(3):192-197. Epub 2018 Oct 9.

Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan; Department of Pharmacy, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.

We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats. Furthermore, we evaluated the role of the serotonin (5-HT) receptor subtype in the anxiety-like behavior induced by such chemotherapy. Rats were intraperitoneally injected with doxorubicin and cyclophosphamide once a week for 2 weeks. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.001DOI Listing
November 2018
13 Reads

Effects of Derinat on ischemia-reperfusion-induced pressure ulcer mouse model.

J Pharmacol Sci 2018 Oct 27;138(2):123-130. Epub 2018 Sep 27.

Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:

Sodium salt of deoxyribonucleic acid (DNA), Derinat, isolated from the soft roes of Russian sturgeon, has been utilized as an immunomodulator for the treatment of reactive oxygen species (ROS)-associated diseases in clinics. Here we show that treatment with Derinat has an anti-inflammatory and anti-oxidative effects on cutaneous ischemia-reperfusion (IR) injury in pressure ulcer (PU) model mice. Dorsal skin damage and dermal edema in mild PU model mice were attenuated by treatment with Derinat. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.013DOI Listing
October 2018
10 Reads

Improved endogenous epoxyeicosatrienoic acid production mends heart function via increased PGC 1α-mitochondrial functions in metabolic syndrome.

J Pharmacol Sci 2018 Oct 4;138(2):138-145. Epub 2018 Oct 4.

Department of Geriatric Cardiology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 100853, China. Electronic address:

Metabolic syndrome (MS) is a combination of symptoms characterized by central obesity, hypertension, hyperglycemia, and hyperlipidemia, which together increase the risk of heart disease, stroke and diabetes. In our study, we hypothesized that an EET-agonist (AUDA) would increase expression of PGC 1α and improve mitochondrial and endothelial functions, resulting in improved heart function in a rat model of MS. To investigate this, rats were randomly divided into four groups: 1) Control; 2) MS + ABCT; 3) MS + AUDA; and 4) MS + AUDA + SnMP. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.010DOI Listing
October 2018
4 Reads