2,610 results match your criteria Journal of Pharmacological Sciences[Journal]


PPARγ overexpression regulates cholesterol metabolism in human L02 hepatocytes.

J Pharmacol Sci 2018 Nov 30. Epub 2018 Nov 30.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, Jiangsu, China. Electronic address:

Peroxisome proliferator-activator receptor (PPAR) γ is a nuclear hormone receptor that regulates glucose homeostasis, lipid metabolism, and adipocyte function. It has been shown that activation of PPARγ can reduce the incidence of gallstone. Herein we aimed to clarify the role of PPARγ in the reduction of gallstones. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.013DOI Listing
November 2018

The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice.

J Pharmacol Sci 2018 Dec 1. Epub 2018 Dec 1.

Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

We recently developed PA-8, a novel small-molecule antagonist of PACAP type 1 (PAC1) receptor. In the present study, we examined whether PA-8 was effective against formalin-induced inflammatory pain in mice. Both intrathecal and oral administration of PA-8 resulted in the dose-dependent attenuation of the second phase of formalin-induced nociceptive responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183021
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http://dx.doi.org/10.1016/j.jphs.2018.11.011DOI Listing
December 2018
1 Read

Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice.

J Pharmacol Sci 2018 Nov 30. Epub 2018 Nov 30.

Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address:

Kamiuntanto (KUT; Jia Wei Wen Dan Tang in Pinyin) is a traditional Japanese Kampo medicine that is used to treat psychological dysfunction. However, the mechanisms of action of KUT are not understood. To investigate the mechanisms underlying the ameliorative properties of KUT, the effects of KUT on abnormal behaviors of isolation-reared mice and on the prefrontal monoaminergic system were examined. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.008DOI Listing
November 2018

Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome.

J Pharmacol Sci 2018 Nov 24. Epub 2018 Nov 24.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan; Department of General Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan.

Visceral hypersensitivity and impaired gut barrier with minor inflammation are considered to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Since pioglitazone is known to have anti-inflammatory property, we hypothesized that pioglitazone is beneficial for treating IBS. In this study, the effect was tested in rat IBS models such as lipopolysaccharide or repeated water avoidance stress-induced visceral allodynia and increased colonic permeability. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.006DOI Listing
November 2018

SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism.

J Pharmacol Sci 2018 Nov 24. Epub 2018 Nov 24.

Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kausmi, Minami-ku, Hiroshima 734-8551, Japan. Electronic address:

The serotonin transporter (SERT) is functionally regulated via membrane trafficking. Our previous studies have demonstrated that the SERT C-terminal deletion mutant (SERTΔCT) showed a robust decrease in its membrane trafficking and was retained in the endoplasmic reticulum (ER), suggesting that SERTΔCT is an unfolded protein that may cause ER stress. The Sigma-1 receptor (SigR1) has been reported to attenuate ER stress via its chaperone activity. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.005DOI Listing
November 2018

The influence of telmisartan on metformin pharmacokinetics and pharmacodynamics.

J Pharmacol Sci 2018 Nov 25. Epub 2018 Nov 25.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan, China. Electronic address:

Metformin is the most widely used drug among type 2 diabetes mellitus patients. However, drug interaction on metformin will influence its glucose-lowering effect or increase its side effect of lactic acidosis. In this study, a randomized, two-stage, crossover study was conducted to unveil the potential drug interaction between metformin and the anti-hypertension drug, telmisartan. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.007DOI Listing
November 2018
1 Read
2.360 Impact Factor

Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart.

J Pharmacol Sci 2018 Nov 24. Epub 2018 Nov 24.

International Clinical Research Center, St. Anne's Faculty Hospital, Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.004DOI Listing
November 2018

Physiological role of nitric oxide for regulation of arterial stiffness in anesthetized rabbits.

J Pharmacol Sci 2018 Nov 24. Epub 2018 Nov 24.

Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan. Electronic address:

We assessed effects of acetylcholine and Nω-Nitro-l-arginine methyl ester hydrochloride (l-NAME) on the cardio-ankle vascular index (CAVI), an indicator of arterial stiffness from origin of aorta to tibial artery, in halothane-anesthetized rabbits. Acetylcholine decreased the blood pressure, femoral vascular resistance and CAVI, whereas l-NAME did not affect the CAVI at a hypertensive dose. The acetylcholine-induced decrement of CAVI was completely suppressed by l-NAME. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.003DOI Listing
November 2018

Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells.

J Pharmacol Sci 2018 Nov 25. Epub 2018 Nov 25.

Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Integrative & Optimized Medicine Research Center, China-USA Institute for Acupuncture and Rehabilitation, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Background: Neuroinflammation plays a major role in the development of ischemic stroke, and regulation of the proinflammatory TLR4 signaling pathway in microglia stands to be a promising therapeutic strategy for stroke intervention. Recently, the homeostasis of mitochondrial dynamics has also been raised as a vital component in maintaining neuronal health, but its relevance in microglia hasn't been investigated. Schaftoside, a natural flavonoid compound and a promising treatment for inflammation, has demonstrated potency against LPS-induced lung inflammation in mice; however, its action on TLR4-induced neuroinflammation and mitochondrial dynamics in microglia is still unknown. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.012DOI Listing
November 2018
2 Reads

Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection.

J Pharmacol Sci 2018 Dec 25;138(4):247-256. Epub 2018 Jun 25.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China. Electronic address:

Dengue virus (DENV) annually infects 400 million people worldwide. Unfortunately, there is lack of widely protective vaccine or drugs against DENV. The viral RNA-dependent RNA polymerase (RdRp) of NS5 protein is highly conserved among different DENV subtypes, thus presenting itself as an attractive target for drug design. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.06.012DOI Listing
December 2018
1 Read
2.360 Impact Factor

Long-term efficacy and safety profile of multiple injections of intravitreal dexamethasone implant to manage diabetic macular edema: A systematic review of real-world studies.

J Pharmacol Sci 2018 Dec 20;138(4):219-232. Epub 2018 Nov 20.

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, Catania, Italy; Center for Research in Ocular Pharmacology, CERFO University of Catania, Catania, Italy; Regional Pharmacovigilance Centre of Catania, A.O.U. Policlinico-Vittorio Emanuele, Catania, Italy.

Introduction: Systematic review of real-world studies about repeated dexamethasone intravitreal implant (DEXi) 0.7 mg in diabetic macular edema management, in order to identify the effective window of time occurring between injections, the critical evaluation of efficacy of the treatment, and the relative long-term safety in the real life setting.

Methods: Literature databases such as PubMed, SCOPUS, and EMBASE were used to identify reports including DEX implant injections. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.001DOI Listing
December 2018
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Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression.

J Pharmacol Sci 2018 Dec 20;138(4):284-288. Epub 2018 Nov 20.

Division of Chemotherapy, Kindai University Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka, 577-8502, Japan. Electronic address:

Psoriasis is a chronic inflammatory skin disease in which inflammatory cytokines play a major role in its pathogenesis. Because DDH-1, a novel amphipathic ascorbic acid derivative, has been recently shown to reduce inflammatory cytokine expression in human keratinocytes in vitro, we investigated its effect on imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice. We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.11.002DOI Listing
December 2018

Activation of c-Jun N-terminal kinase and p38 after cerebral ischemia upregulates cerebral sodium-glucose transporter type 1.

J Pharmacol Sci 2018 Dec 7;138(4):240-246. Epub 2018 Nov 7.

Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe 650-8586, Japan. Electronic address:

Cerebral ischemic stress increases cerebral sodium-glucose transporter type 1 (SGLT-1). However, the mechanism by which cerebral ischemia leads to the up-regulation of SGLT-1 remains unclear. In peripheral tissue, the activation of mitogen-activated protein kinases (MAPKs) increases SGLT-1. Read More

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http://dx.doi.org/10.1016/j.jphs.2017.02.016DOI Listing
December 2018

Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model.

J Pharmacol Sci 2018 Dec 2;138(4):257-262. Epub 2018 Oct 2.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Cichorium glandulosum Boiss. et Huet (CG) is a common traditional Uighur medicine, and it has been widely used as active therapy on various hepatic diseases. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.012DOI Listing
December 2018

MiR-532 downregulation of the Wnt/β-catenin signaling via targeting Bcl-9 and induced human intervertebral disc nucleus pulposus cells apoptosis.

J Pharmacol Sci 2018 Dec 23;138(4):263-270. Epub 2018 Oct 23.

Department of Orthopedic, Guizhou Provincial People's Hospital, Guizhou, 550002, China. Electronic address:

Objective: Intervertebral disc degeneration was characterized with aberrant intervertebral disc nucleus pulposus cells apoptosis. MiR-532 was reported to be up-regulated in the patients with intervertebral disc degeneration. However, the role of miR-532 in intervertebral disc degeneration remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183019
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http://dx.doi.org/10.1016/j.jphs.2018.10.007DOI Listing
December 2018
1 Read

Protocatechuic acid inhibits TGF-β1-induced proliferation and migration of human airway smooth muscle cells.

J Pharmacol Sci 2018 Nov 5. Epub 2018 Nov 5.

Department of Pediatrics, Xijing Hospital, The Fourth Military Medial University, Xi'an, Shaanxi, PR China.

Protocatechuic acid (3, 4-dihydroxybenzoic acid, PCA) is a major metabolite of anthocyanins and was reported to possess anti-allergic response. However, the effects of PCA on airway smooth muscle cells (ASMCs) proliferation and migration remain unclear. Therefore, this study aims to investigate the effects of PCA on proliferation and migration of ASMCs. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.011DOI Listing
November 2018
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Inhibitory effects of Kampo medicines, Keishibukuryogan and Shakuyakukanzoto, on the substrate uptake activities of solute carrier organic anion transporters.

J Pharmacol Sci 2018 Dec 24;138(4):279-283. Epub 2018 Oct 24.

The K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea. Electronic address:

The aim of this study was to assess the effects of Keishibukuryogan (K-06) and Shakuyakukanzoto (TJ-68), commercial herbal medicines, on the substrate uptake activities of renal organic anion transporters. We performed transporter uptake and cell viability assays in Xenopus oocytes and HEK293 human kidney embryonic cells treated with K-06 or TJ-68. K-06 and TJ-68 markedly inhibited the substrate uptake activities of URAT1, OAT1, and OAT3, while they did not exhibit non-cytotoxic effects. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.008DOI Listing
December 2018
4 Reads

SBF-1 preferentially inhibits growth of highly malignant human liposarcoma cells.

J Pharmacol Sci 2018 Dec 24;138(4):271-278. Epub 2018 Oct 24.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. Electronic address:

Frequent local recurrence and metastasis are generally involved in human liposarcoma, but the management is a challenge. There is an urgent need for improved effective therapy. In the present study, we reported that SBF-1, a steroidal glycoside, inhibited the growth of cultured highly malignant human liposarcoma SW872-S cells in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.009DOI Listing
December 2018
4 Reads
2.360 Impact Factor

Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update.

J Pharmacol Sci 2018 Dec 24;138(4):233-239. Epub 2018 Oct 24.

Japan iPS Cardiac Safety Assessment (JiCSA), Japan; The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Cardiac safety assessment is challenging because a better understanding of torsadogenic mechanisms beyond hERG blockade and QT interval prolongation is necessary for patient safety. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a new human cell-based platform to assess cardiac safety in non-clinical testing during drug development. The multi-electrode array (MEA) platform is a promising electrophysiological technology to assess QT interval prolongation and proarrhythmic potential of drug candidates using hiPSC-CMs. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.010DOI Listing
December 2018
1 Read

Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats.

J Pharmacol Sci 2018 Nov 26;138(3):214-217. Epub 2018 Oct 26.

Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.

Oxaliplatin causes acute cold hypersensitivity in most patients. We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats. In this study, we examined the effect of riluzole on oxaliplatin-induced cold allodynia. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.006DOI Listing
November 2018
5 Reads

Anti-angiogenic effects of valproic acid in a mouse model of oxygen-induced retinopathy.

J Pharmacol Sci 2018 Nov 14;138(3):203-208. Epub 2018 Oct 14.

Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Pathological retinal angiogenesis contributes to the pathogenesis of several ocular diseases. Valproic acid, a widely used antiepileptic drug, exerts anti-angiogenic effects by inhibiting histone deacetylase (HDAC). Herein, we investigated the effects of valproic acid and vorinostat, a HDAC inhibitor, on pathological retinal angiogenesis in mice with oxygen-induced retinopathy (OIR). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183018
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http://dx.doi.org/10.1016/j.jphs.2018.10.004DOI Listing
November 2018
4 Reads

Water-extracted branch of Cinnamomum cassia promotes lung cancer cell apoptosis by inhibiting pyruvate dehydrogenase kinase activity.

J Pharmacol Sci 2018 Oct 18;138(2):146-154. Epub 2018 Oct 18.

Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Busandaehak-ro 49, Yangsan, Gyeongnam 50612, Republic of Korea; Healthy Aging Korean Medical Research Center, Pusan National University, Busandaehak-ro 49, Yangsan, Gyeongnam 50612, Republic of Korea; Graduate Training Program of Korean Medicine for Healthy-aging, Pusan National University, Busandaehak-ro 49, Yangsan, Gyeongnam 50612, Republic of Korea. Electronic address:

Cinnamomum cassia Blume has been widely reported as the anti-tumor agent. However, the precise mechanism underlying its pro-apoptotic action is still not clear. Restraining aerobic glycolysis through suppression of pyruvate dehydrogenase kinase (PDHK) is a promising strategy for cancer inhibition. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.005DOI Listing
October 2018
3 Reads

Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death.

J Pharmacol Sci 2018 Nov 17;138(3):198-202. Epub 2018 Oct 17.

Department of Pharmacology, Toho University Graduate School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan. Electronic address:

Although azithromycin can suppress cardiac I, I, I, I and I, its onset mechanisms for cardiovascular death have not been fully investigated. We examined electropharmacological effects of azithromycin in intravenous doses of 0.3, 3 and 30 mg/kg using microminipigs under the halothane anesthesia (n = 4), which provided plasma concentrations of 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183018
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http://dx.doi.org/10.1016/j.jphs.2018.10.003DOI Listing
November 2018
7 Reads

Maslinic acid protects against pressure overload-induced cardiac hypertrophy in mice.

J Pharmacol Sci 2018 Oct 14;138(2):116-122. Epub 2018 Oct 14.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China. Electronic address:

Cardiac hypertrophy is characterized by myocyte hypertrophy, accumulation of cardiac collagen, and reactivation of fetal genes. Maslinic acid (MA) is a pentacyclic triterpene with abundance in olive fruit skin and possesses a number of pharmacological actions. However, its effect on pressure overload-induced cardiac hypertrophy remains unknown. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.014DOI Listing
October 2018

Dual effect of polyphosphate on mineralization of rat osteoblast ROS17/2.8 cells in a dose-dependent manner.

J Pharmacol Sci 2018 Nov 13;138(3):209-213. Epub 2018 Oct 13.

Department of Biochemistry, Nihon University School of Dentistry, 1-8-13 Kanda Surugadai Chiyoda-ku, Tokyo 101-8310, Japan. Electronic address:

Inorganic polyphosphate (polyP), a linear polymer of orthophosphate, is found at high concentrations in osteoblasts. We demonstrated the effects of various polyP concentrations on the mineralization of rat osteoblast ROS17/2.8 cells. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.002DOI Listing
November 2018

A Rho-kinase inhibitor reverses learning and memory deficits in a Rat model of chronic cerebral ischemia by altering Bcl-2/Bax-NMDAR signaling in the cerebral cortex.

J Pharmacol Sci 2018 Oct 22;138(2):107-115. Epub 2018 Sep 22.

Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai, 200080, PR China. Electronic address:

The current study investigated whether a Rho-kinase inhibitor alleviated impairments in a rat model of chronic cerebral ischemia and examined the specific pathological mechanisms by which Rho-kinase impacts neuronal damage and cognitive dysfunction. Adult Sprague-Dawley rats underwent permanent bilateral carotid artery occlusion (BCAO) to establish our chronic cerebral ischemia model. Chronic Y27632 administration reversed the abnormal behaviors of BCAO-treated rats in the Morris water maze. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183017
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http://dx.doi.org/10.1016/j.jphs.2018.08.012DOI Listing
October 2018
5 Reads

Involvement of 5-HT receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats.

J Pharmacol Sci 2018 Nov 9;138(3):192-197. Epub 2018 Oct 9.

Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan; Department of Pharmacy, Okayama University Hospital, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.

We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats. Furthermore, we evaluated the role of the serotonin (5-HT) receptor subtype in the anxiety-like behavior induced by such chemotherapy. Rats were intraperitoneally injected with doxorubicin and cyclophosphamide once a week for 2 weeks. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.10.001DOI Listing
November 2018
7 Reads

Effects of Derinat on ischemia-reperfusion-induced pressure ulcer mouse model.

J Pharmacol Sci 2018 Oct 27;138(2):123-130. Epub 2018 Sep 27.

Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:

Sodium salt of deoxyribonucleic acid (DNA), Derinat, isolated from the soft roes of Russian sturgeon, has been utilized as an immunomodulator for the treatment of reactive oxygen species (ROS)-associated diseases in clinics. Here we show that treatment with Derinat has an anti-inflammatory and anti-oxidative effects on cutaneous ischemia-reperfusion (IR) injury in pressure ulcer (PU) model mice. Dorsal skin damage and dermal edema in mild PU model mice were attenuated by treatment with Derinat. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.013DOI Listing
October 2018
6 Reads

Improved endogenous epoxyeicosatrienoic acid production mends heart function via increased PGC 1α-mitochondrial functions in metabolic syndrome.

J Pharmacol Sci 2018 Oct 4;138(2):138-145. Epub 2018 Oct 4.

Department of Geriatric Cardiology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 100853, China. Electronic address:

Metabolic syndrome (MS) is a combination of symptoms characterized by central obesity, hypertension, hyperglycemia, and hyperlipidemia, which together increase the risk of heart disease, stroke and diabetes. In our study, we hypothesized that an EET-agonist (AUDA) would increase expression of PGC 1α and improve mitochondrial and endothelial functions, resulting in improved heart function in a rat model of MS. To investigate this, rats were randomly divided into four groups: 1) Control; 2) MS + ABCT; 3) MS + AUDA; and 4) MS + AUDA + SnMP. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.010DOI Listing
October 2018
1 Read

Interleukin-6 induced by YAP in hepatocellular carcinoma cells recruits tumor-associated macrophages.

J Pharmacol Sci 2018 Oct 22;138(2):89-95. Epub 2018 Sep 22.

Zhejiang Province Key Laboratory of Anti-cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Tumor-associated macrophages (TAMs) has been regarded as the most prominent component in tumor microenvironment. The correlation between TAM density and poor prognosis in Hepatocellular carcinoma (HCC) patients suggests a supportive role for TAMs in tumor progression. Here we employed a co-culture system to interrogate the molecular link between Yes-Associated Protein (YAP) and TAMs chemotaxis in HCC cells. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.07.013DOI Listing
October 2018
1 Read

Artesunate enhances radiosensitivity of esophageal cancer cells by inhibiting the repair of DNA damage.

J Pharmacol Sci 2018 Oct 29;138(2):131-137. Epub 2018 Sep 29.

Department of Tumor Rehabilitation, The 1st Affiliated Hospital of Wenzhou Medical University, No.2 Fuxue Lane, Wenzhou, Zhejiang Province, 325000, China. Electronic address:

Radiotherapy plays an important therapeutic role in esophageal cancer (EC). However, acquired radioresistance impairs the efficacy of radiotherapy, often leading to treatment failure. Therefore, it is important to develop novel radiosensitizers to enhance the clinical treatment of EC. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.011DOI Listing
October 2018

MicroRNA-370 inhibits the proliferation, invasion and EMT of gastric cancer cells by directly targeting PAQR4.

J Pharmacol Sci 2018 Oct 25;138(2):96-106. Epub 2018 Aug 25.

Department of Nephrology, First Hospital of Jilin University, Jilin, 130021, China. Electronic address:

It has been reported that PAQR4 (Progestin and AdipoQ Receptor 4) expression is closely associated with progression of many cancers and microRNA (miRNA) processing. However, the effects and its precise mechanisms of PAQR4 in gastric cancer (GC) have not been well clarified. Our study aimed to explore the interaction between PAQR4 and miR-370 in GC. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.004DOI Listing
October 2018

A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.

J Pharmacol Sci 2018 Nov 27;138(3):176-183. Epub 2018 Sep 27.

Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8553, Japan. Electronic address:

We previously reported that systemic administration of a delta opioid receptor (DOP) agonist, KNT-127, produced a potent anxiolytic-like effect in rats. Interestingly, DOPs are highly distributed in the prelimbic medial prefrontal cortex (PL-PFC). In the present study, we investigated the effect of KNT-127 co-perfusion in the PL-PFC on anxiety-like behavior in mice, induced by a glial glutamate transporter inhibitor, (3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-l-aspartic acid (TFB-TBOA). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.009DOI Listing
November 2018

γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice.

J Pharmacol Sci 2018 Oct 7;138(2):155-159. Epub 2018 Jun 7.

Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan. Electronic address:

We evaluated the anxiolytic effect of γ-oryzanol (GORZ) and elucidated the molecular mechanisms involved in its inhibition of behavioral test-induced anxiety. Behavioral tests were conducted on day 13, and mice were subjected to 30 min of acute restraint stress treatment (ARST) before sacrifice on day 16. In other group, behavioral tests were conducted on day 13 and 14 after ARST. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.06.003DOI Listing
October 2018
1 Read

Prolonged stimulation of β-adrenergic receptor with β-agonists impairs insulin actions in H9c2 cells.

J Pharmacol Sci 2018 Nov 26;138(3):184-191. Epub 2018 Sep 26.

Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. Electronic address:

Insulin resistance is a condition in which there is a defect in insulin actions to induce glucose uptake into the cells. Overstimulation of β-adrenergic receptors (βARs) is associated with the pathogenesis of insulin resistance in the heart. However, the mechanisms by which β-agonists affect insulin resistance in the heart are incompletely understood. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.007DOI Listing
November 2018
2 Reads
2.360 Impact Factor

Na, K-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities.

J Pharmacol Sci 2018 Nov 22;138(3):167-175. Epub 2018 Sep 22.

Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan. Electronic address:

Na, K-ATPase is a highly expressed membrane protein. Dysfunction of Na, K-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting from Na, K-ATPase dysfunction is poorly understood. Here, we investigated the mechanism of neurotoxicity due to Na, K-ATPase inhibition using rat organotypic hippocampal slice cultures. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.004DOI Listing
November 2018
3 Reads

Mogroside IIIE attenuates gestational diabetes mellitus through activating of AMPK signaling pathway in mice.

J Pharmacol Sci 2018 Nov 26;138(3):161-166. Epub 2018 Sep 26.

Heze Municipal Hospital, No. 2888, Caozhou Road, Mudan District, Heze City 274000, Shandong Province, China. Electronic address:

As one kind of complications of pregnancy, gestational diabetes mellitus (GDM) can influence the health of maternal-child in clinical practice. The C57 BL/KsJ(db/+) mice, genetic GDM model, and C57 BL/KsJ (wild-type) mice were purchased and classified into three groups: normal pregnancy (C57 BL/KsJ), GDM (C57 BL/KsJ), and GDM plus Mogroside IIIE (20.0 mg/kg) group. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.008DOI Listing
November 2018
2 Reads

C-terminal site-specific PEGylated Exendin-4 analog: A long-acting glucagon like Peptide-1 receptor agonist, on glycemic control and beta cell function in diabetic db/db mice.

J Pharmacol Sci 2018 Sep 31;138(1):23-30. Epub 2018 Aug 31.

Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

PEG modification is a common clinical strategy for prolonging the half-life of therapeutic proteins or polypeptides. In a previous work, we have successfully synthesized PEG-modified Exendin-4 (PE) by conjugating a 20 kDa PEG to the C-terminal of Exendin-4. Then, we introduced an integrative characterization for PE to evaluate its hypoglycemic activity and pharmacokinetic properties. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.009DOI Listing
September 2018
1 Read

Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats.

J Pharmacol Sci 2018 Sep 10;138(1):54-62. Epub 2018 Sep 10.

Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan.

Narrowband-ultraviolet B (NB-UVB) phototherapy is used for the treatment of atopic dermatitis. Previously, we reported that irradiation with 200 mJ/cm of 310 nm NB-UVB suppressed phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H receptor (H1R) gene expression without induction of apoptosis in HeLa cells. However, the effect of NB-UVB irradiation on nasal symptoms is still unclear. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.011DOI Listing
September 2018
2 Reads

Relationship between the fluorescence intensity of rhodamine-labeled orexin A and the calcium responses in cortical neurons: An in vivo two-photon calcium imaging study.

J Pharmacol Sci 2018 Sep 22;138(1):76-82. Epub 2018 Sep 22.

Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Molecular Dynamics Imaging Unit, RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan. Electronic address:

Neural responses to a ligand vary widely between neurons; however, the mechanisms underlying this variation remain unclear. One possible mechanism is a variation in the number of receptors expressed in each neural membrane. Here, we synthesized a rhodamine-labeled orexin A compound, enabling us to quantify the amount of orexin binding to its receptors, OX and OX, which principally couple to the G protein. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.005DOI Listing
September 2018
13 Reads

Anti-tumor activity of Escherichia coli Shiga toxin A subunit delivered by SF9 insect cells.

J Pharmacol Sci 2018 Sep 22;138(1):71-75. Epub 2018 Sep 22.

Molecular Biology Department, Pasteur Institute of Iran, Tehran, Iran.

Cancer remains a major health problem around the world. A Shiga toxin is a bacterial toxin often produced by Shigella dysenteriae and Escherichia coli. A subunit of the Shiga toxin (StxA) is a cytotoxic agent which could be used to induce death in cancer cells. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.003DOI Listing
September 2018
2 Reads

Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice.

J Pharmacol Sci 2018 Sep 26;138(1):86-88. Epub 2018 Sep 26.

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan. Electronic address:

Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS (0. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.006DOI Listing
September 2018
5 Reads

Administration of cinnamaldehyde promotes osteogenesis in ovariectomized rats and differentiation of osteoblast in vitro.

J Pharmacol Sci 2018 Sep 11;138(1):63-70. Epub 2018 Sep 11.

Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang Province, People's Republic of China. Electronic address:

To explore the effect of cinnamaldehyde on the distal femur in ovariectomized rats and its influence on osteoblast in vitro. Female Sprague-Dawley rats which underwent either bilateral ovariectomy or sham operation were divided into five groups randomly: group OVX (OVX, N = 10) and group sham (SHAM, N = 10) received normal saline (NS) by gavage at a dose of 50 ml/kg·d; group low dose, group middle dose and group high dose received cinnamaldehyde by gavage at a dose of 25 mg/kg·d (OLD, N = 10), 50 mg/kg·d (OMD, N = 10), and 75 mg/kg·d (OHD, N = 10) respectively. Distal femurs were harvested for hematoxylin and eosin (HE) staining, micro-ct scanning and immunohistochemical analysis. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.002DOI Listing
September 2018
1 Read

Probing the benzofuroquinolinium derivative as a potent antibacterial agent through the inhibition of FtsZ activity.

J Pharmacol Sci 2018 Sep 10;138(1):83-85. Epub 2018 Sep 10.

School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China; International Healthcare Innovation Institute (Jiangmen), 529040, PR China. Electronic address:

A benzofuroquinolinium derivative that exhibits excellent cell division inhibitory effect was discovered through cell-based screening approach. This compound possesses potent antimicrobial activity against both Gram-positive and Gram-negative bacteria including the drug-resistant strains. In addition, this compound is able to restore MRSA susceptibility to beta-lactam antibiotics. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.09.001DOI Listing
September 2018
1 Read
2.360 Impact Factor

Polydatin alleviated alcoholic liver injury in zebrafish larvae through ameliorating lipid metabolism and oxidative stress.

J Pharmacol Sci 2018 Sep 7;138(1):46-53. Epub 2018 Sep 7.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Hepatic steatosis is the early stage of alcoholic liver disease (ALD), may progress to steatohepatitis, fibrosis even cirrhosis. Polydatin, the primary active component of Polygonum cuspidatum Sieb. et Zucc, has been recognized to possess hepatoprotective and anti-inflammatory properties. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.007DOI Listing
September 2018
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Inhibitory effect of the gut microbial linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation.

J Pharmacol Sci 2018 Sep 5;138(1):9-15. Epub 2018 Sep 5.

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan. Electronic address:

10-oxo-trans-11-octadecenoic acid (KetoC) and 10-hydroxy-cis-12-octadecenoic acid (HYA) are long-chain fatty acids generated from linoleic acid by the gut lactic acid bacterium Lactobacillus plantarum. These fatty acids have been reported to have anti-inflammatory activity in the intestine. However, little is known about their effects in the brain. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.06.015DOI Listing
September 2018

Icariside II attenuates cardiac remodeling via AMPKα2/mTORC1 in vivo and in vitro.

J Pharmacol Sci 2018 Sep 4;138(1):38-45. Epub 2018 Sep 4.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute of Wuhan University, Wuhan, China; Hubei Key Laboratory of Cardiology, Wuhan, China. Electronic address:

Icariside II (ICA II), a flavonoid derived from Epimediumbrevicormum Maxin in, has multiple biological activities in Chinese traditional medicine. Our study aimed to investigate the potential activity of ICA II against cardiac remodeling and the underlying mechanism. Mice received aorta banding (AB) or sham surgery, and then were randomly divided into ICA II or vehicle (veh) group for 6 weeks. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.010DOI Listing
September 2018
2.360 Impact Factor

Neuroprotective effects of pramipexole transdermal patch in the MPTP-induced mouse model of Parkinson's disease.

J Pharmacol Sci 2018 Sep 26;138(1):31-37. Epub 2018 Aug 26.

Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, PR China. Electronic address:

Parkinson's disease (PD) is characterized by the selective death of dopaminergic neurons. To avoid inconvenience of frequent administration caused by short half life and recurrence of symptoms such as tremor and bradykinesia incurred by drug elimination, a novel long-acting pramipexole transdermal patch has been made. In the present study, we evaluated the neuroprotective effects and underlying mechanisms of pramipexole patch (PPX patch) in a subacute PD mouse model induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.008DOI Listing
September 2018
16 Reads

Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion.

J Pharmacol Sci 2018 Sep 25;138(1):16-22. Epub 2018 Aug 25.

Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China; Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, 100053, China; Beijing Institute for Brain Disorders, Beijing, 100053, China. Electronic address:

Nitrosative/oxidative stress plays an important role in neuronal death following cerebral ischemia/reperfusion (I/R). Chrysophanol (CHR) has been shown to afford significant neuroprotection on ischemic stroke, however, whether its mechanism is related to attenuating nitrosative/oxidative stress is not clear. In the present study, we investigated the effect of CHR on neuronal injury related to nitric oxide (NO) production by using mouse middle cerebral artery occlusion (MCAO) model. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.002DOI Listing
September 2018
7 Reads

Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats.

J Pharmacol Sci 2018 Aug 25;137(4):395-402. Epub 2018 Aug 25.

Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Oko, Nankoku, Kochi 783-8505, Japan.

The maladaptive response of aged microglia to surgery and consequent neuroinflammation plays a key pathogenic role in postoperative cognitive dysfunction (POCD). Here, we assessed the preventive effect of resveratrol (RESV) for POCD in aged rats. The emulsified form of RESV (e-RESV) was selected to improve its oral and brain bioavailability. Read More

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http://dx.doi.org/10.1016/j.jphs.2018.08.006DOI Listing