274 results match your criteria Journal of Pharmaceutical Finance Economics & Policy[Journal]


The Fourth Industrial Revolution: Will it change pharmacy practice?

Res Social Adm Pharm 2019 Apr 16. Epub 2019 Apr 16.

Research & Development, Pharmakon, Danish College of Pharmacy Practice, Denmark. Electronic address:

The industrial world is at the beginning of a Fourth Industrial Revolution (4IR). This era will radically change the human use of technology, with major implications for the ways people live and work. This commentary asks: will 4IR change pharmacy practice? The first three revolutions created the pharmaceutical industry and gave pharmacists a near-monopoly over drug supply. Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.04.003DOI Listing

The price of innovation - the role of drug pricing in financing pharmaceutical innovation. A conceptual framework.

J Mark Access Health Policy 2019 20;7(1):1583536. Epub 2019 Mar 20.

Department of Applied Economics, University of Granada, Campus de Cartuja, Granada, Spain.

The debate on drug prices has reached new heights with the controversy around the role of prices in promoting innovation. Critics claim that prices of innovative drugs are excessive and argue that lowering prices will not harm the flourishing innovation. On the opposite end, the pharmaceutical industry insists that restrictive pricing policies will have a detrimental impact on their ability to generate innovation. Read More

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http://dx.doi.org/10.1080/20016689.2019.1583536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442120PMC
March 2019
1 Read

Covalent Interaction between Rice Protein Hydrolysates and Chlorogenic Acid: Improving the Stability of Oil-in-Water Emulsions.

J Agric Food Chem 2019 Apr 1;67(14):4023-4030. Epub 2019 Apr 1.

College of Food Science and Engineering , Nanjing University of Finance and Economics/Key Laboratory of Grains and Oils Quality Control and Processing, Collaborative Innovation Center for Modern Grain Circulation and Safety , Nanjing 210023 , China.

Protein hydrolysates, as surfactants, can scavenge radicals, but their poor distributions at the oil-water interface limit their storage stability. Therefore, we studied covalent interaction between rice protein hydrolysates and chlorogenic acid under alkaline conditions to improve the physical and oxidative stability of oil-in-water emulsions. Turbidity and particle size measurements demonstrated the formation of hydrolysates-chlorogenic acid complexes, and their covalent interaction resulted in the decrease and redshift of the fluorescence intensity. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06898DOI Listing
April 2019
5 Reads

Use of medicine pricing and reimbursement policies for universal health coverage in Indonesia.

PLoS One 2019 19;14(2):e0212328. Epub 2019 Feb 19.

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Objectives: This study aimed to define the problems of the current use of the e-Catalogue and the national formulary (NF)-two elements of medicine pricing and reimbursement policies in Indonesia for achieving universal health coverage (UHC)-by examining the knowledge and attitudes of stakeholders. Specifically, to investigate (1) the perceived challenges involved in the further implementation of the e-Catalogue and the NF, (2) reasons of prescribing medicines not listed in the NF, and (3) possible improvements in the acceptance and use of the e-Catalogue and the NF.

Methods: Semi-structured interviews were conducted with stakeholders (policymakers, healthcare providers, a pharmaceutical industry representative, and experienced patients) to collect the qualitative data. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212328PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380537PMC
February 2019

Influence of gene regulation on rice quality: Impact of storage temperature and humidity on flavor profile.

Food Chem 2019 Jun 16;283:141-147. Epub 2019 Jan 16.

Department of Food Quality and Safety/National R&D Center For Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing, Jiangsu 211198, China. Electronic address:

Effects of high temperature-high humidity (HT-HH) storage on the flavor profile of rice were investigated. Volatile compounds such as aldehydes, ketones, and furans increased when rice was stored under HT-HH conditions, leading to a pronounced deterioration in rice quality. Correspondingly, the fatty acid content of the rice significantly increased during storage. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.01.042DOI Listing

Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates.

Sex Transm Infect 2019 02 21;95(1):28-35. Epub 2018 Sep 21.

National Infection Service, Public Health England, London, UK

Background: Many economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.

Methods: We conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider's perspective. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053606
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http://dx.doi.org/10.1136/sextrans-2018-053606DOI Listing
February 2019
7 Reads

Health-related quality of life in Indonesian type 2 diabetes mellitus outpatients measured with the Bahasa version of EQ-5D.

Qual Life Res 2019 May 16;28(5):1179-1190. Epub 2019 Jan 16.

Unit of Pharmacotherapy, Epidemiology & Economics (PTE2), Department of Pharmacy, Faculty of Science and Engineering (FSE), University of Groningen, Groningen, The Netherlands.

Objectives: To present EuroQol-5D (EQ-5D) index scores in Indonesian type 2 diabetes mellitus (T2DM) outpatients and to investigate the associations between EQ-5D and socio-demographic characteristics and clinical condition.

Methods: Socio-demographic data were collected by interviewing participants, clinical data were obtained from treating physicians and self-reporting. Participants originated from primary and secondary care facilities in the Java and Sulawesi regions. Read More

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http://dx.doi.org/10.1007/s11136-019-02105-zDOI Listing
May 2019
4 Reads
2.486 Impact Factor

Protective effects of p-coumaric acid against oxidant and hyperlipidemia-an in vitro and in vivo evaluation.

Biomed Pharmacother 2019 Mar 31;111:579-587. Epub 2018 Dec 31.

Department of Chemistry, Temple University, Philadelphia, 19122, USA. Electronic address:

Dietary phenols are antioxidants with diverse physiological functions that are beneficial for human health. The objective of this research work was to investigate antioxidant activity of p-coumaric acid (p-CA) using four in vitro methods, the protective effects against oxidative stress in PC12 cells, and hypolipidemic effects on High fat-diet (HFD) mice model. The p-CA exhibited moderate antioxidant activity in the selected in vitro assay. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.12.074DOI Listing
March 2019
5 Reads
2.023 Impact Factor

Economic burden of rotavirus diarrhea in Thailand: Report from a pilot study on rotavirus vaccination.

Vaccine 2019 Jan 19;37(4):587-594. Epub 2018 Dec 19.

Unit of PharmacoTherapy, -Epidemiology & -Economics, University of Groningen, Groningen Research Institute of Pharmacy (GRIP), Groningen, the Netherlands; Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Economics, Econometrics & Finance, University of Groningen, Faculty of Economics & Business, Groningen, the Netherlands.

Background: Rotavirus diarrhea is the leading cause of morbidity and mortality in young children in both developed and developing countries. Hospitalization costs are a significant burden of both governments and households. The objective of this study was to estimate the economic burden associated with the hospitalization of children with non-rotavirus and rotavirus diarrhea in two provinces in Thailand. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183167
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http://dx.doi.org/10.1016/j.vaccine.2018.12.013DOI Listing
January 2019
13 Reads

Barriers for Access to New Medicines: Searching for the Balance Between Rising Costs and Limited Budgets.

Front Public Health 2018 5;6:328. Epub 2018 Dec 5.

Health Economics Centre, University of Liverpool Management School, Liverpool, United Kingdom.

There is continued unmet medical need for new medicines across countries especially for cancer, immunological diseases, and orphan diseases. However, there are growing challenges with funding new medicines at ever increasing prices along with funding increased medicine volumes with the growth in both infectious diseases and non-communicable diseases across countries. This has resulted in the development of new models to better manage the entry of new medicines, new financial models being postulated to finance new medicines as well as strategies to improve prescribing efficiency. Read More

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http://dx.doi.org/10.3389/fpubh.2018.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290038PMC
December 2018
14 Reads

Resveratrol Delivery by Albumin Nanoparticles Improved Neurological Function and Neuronal Damage in Transient Middle Cerebral Artery Occlusion Rats.

Front Pharmacol 2018 4;9:1403. Epub 2018 Dec 4.

Department of Geriatric Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Human serum albumin (HSA) is an intrinsic protein and important carrier that transports endogenous as well as exogenous substances. It is demonstrated in this study that the regional accumulation of albumin in the ischemia-reperfusion (I/R) brain may lead in the application of HSA based nanoparticles in the study of cerebral I/R injury. Resveratrol (RES) is potential in the treatment of cerebral I/R injury but is restricted for its water insolubility and short half-life . Read More

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http://dx.doi.org/10.3389/fphar.2018.01403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288361PMC
December 2018
2 Reads

Cost-effectiveness of vaccination of immunocompetent older adults against herpes zoster in the Netherlands: a comparison between the adjuvanted subunit and live-attenuated vaccines.

BMC Med 2018 12 6;16(1):228. Epub 2018 Dec 6.

Unit of PharmacoTherapy, -Epidemiology & -Economics (PTE2), University of Groningen, Groningen Research Institute of Pharmacy, Groningen, The Netherlands.

Background: The newly registered adjuvanted herpes zoster subunit vaccine (HZ/su) has a higher efficacy than the available live-attenuated vaccine (ZVL). National decision-makers soon need to decide whether to introduce HZ/su or to prefer HZ/su above ZVL.

Methods: Using a Markov model with a decision tree, we conducted a cost-effectiveness analysis of vaccination with HZ/su (two doses within 2 months) or zoster vaccine live (ZVL) (single dose, or single dose with a booster after 10 years) for cohorts of 50-, 60-, 70- or 80-year-olds in the Netherlands. Read More

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https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291
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http://dx.doi.org/10.1186/s12916-018-1213-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282315PMC
December 2018
10 Reads

A Systematic Review on the Extent and Quality of Pharmacoeconomic Publications in Egypt.

Clin Drug Investig 2019 Feb;39(2):157-168

Department of Accounting, Finance and Economics, Bournemouth University, Fern Barrow, Poole, Dorset, BH12 5BB, UK.

Background: Egypt faces many challenges when matching patient needs with available resources. Consequently, there has been an increasing interest in pharmacoeconomics as an aid tool in health decision-making to better allocate resources.

Objectives: To review and evaluate the volume and the quality of published pharmacoeconomic studies in Egypt. Read More

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http://dx.doi.org/10.1007/s40261-018-0730-5DOI Listing
February 2019
14 Reads

In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer.

ACS Appl Mater Interfaces 2018 Dec 21;10(48):41056-41069. Epub 2018 Nov 21.

Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy , University of Toronto , 144 College Street , Toronto M5S 3M2 , Canada.

Intracellular activation of nanomaterials within cancer cells presents a powerful means to enhance anticancer specificity and efficacy. In light of upregulated lysosomal protease cathepsin-B (CathB) in many types of invasive cancer cells, herein, we exploit CathB-catalyzed biodegradation of acetylated rapeseed protein isolate (ARPI) to design polymer-drug nanocomplexes that can produce proapoptotic peptides in situ and synergize chemotherapy. ARPI forms nanocomplexes with chitosan (CS) and anticancer drug doxorubicin (DOX) [DOX-ARPI/CS nanoparticles (NPs)] by ionic self-assembly. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b14001
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http://dx.doi.org/10.1021/acsami.8b14001DOI Listing
December 2018
40 Reads

Cost-Utility of an Objective Biochemical Measure to Improve Adherence to Antihypertensive Treatment.

Hypertension 2018 Nov;72(5):1117-1124

From the Unit of PharmacoTherapy, -Epidemiology, and -Economics, Department of Pharmacy, University of Groningen, The Netherlands (A.V.v.S., A.D.I.v.A., M.J.P.).

Nonadherence to antihypertensive medications is known to be a major health problem. Novel biochemical analyses using liquid chromatography-tandem mass spectrometry are becoming accepted as a clinically useful objective measure to manage (non)adherence in Hypertension Clinics. Discussion of results from such analyses with patients can significantly improve adherence and blood pressure control. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11227DOI Listing
November 2018
15 Reads

Estimating the economic impact of canine rabies to Viet Nam 2005-2014.

PLoS Negl Trop Dis 2018 10 11;12(10):e0006866. Epub 2018 Oct 11.

United Nations Development Program, International Trade and Development, Hanoi, Viet Nam.

The global economic impact of canine rabies has been estimated by several studies. Asia bears a disproportionate burden of this zoonosis due to high levels of human deaths and rates of post-exposure prophylaxis (PEP), but low investment in preventative dog vaccination. The same factors that cause rabies to burden much of Asia are also present in Viet Nam. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006866
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http://dx.doi.org/10.1371/journal.pntd.0006866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199002PMC
October 2018
17 Reads

Pharmaceutical expenditure and gross domestic product: Evidence of simultaneous effects using a two-step instrumental variables strategy.

Health Econ 2019 Jan 10;28(1):101-122. Epub 2018 Oct 10.

Economics Department, Frankfurt School of Finance and Management, Frankfurt, Germany.

This paper estimates the income elasticity of government pharmaceutical spending and assesses the simultaneous effect of such spending on gross domestic product (GDP). Using a panel dataset for 136 countries from 1995 to 2006, we employ a two-step instrumental variable procedure where we first estimate the effect of GDP on public pharmaceutical expenditure using tourist receipts as an instrument for GDP. In the second step, we construct an adjusted pharmaceutical expenditure series where the response of public pharmaceutical expenditure to GDP is partialled out and use this endogeneity adjusted series as an instrument for pharmaceutical expenditure. Read More

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http://dx.doi.org/10.1002/hec.3832DOI Listing
January 2019
1 Read

An examination of opioid prescription for Medicare Part D patients among family practice prescribers.

Fam Pract 2018 Sep 19. Epub 2018 Sep 19.

Department of Pharmacy Practice, Samford University, Birmingham, AL, USA.

Background: In the USA, opioid overdose accounted for more than 60% of drug overdose deaths in 2015. Of these deaths, 40% were due to use of prescription opioids.

Objectives: The aims of the study were to (i) study family medicine physician opioid-prescribing rate and duration of prescription, (ii) study the distribution of prescription by medication potency, (iii) study opioid-prescribing trends in health care shortage areas and (iv) study the association between extreme high prescribing rates and medical board discipline. Read More

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http://dx.doi.org/10.1093/fampra/cmy090DOI Listing
September 2018
2 Reads

Cost-effectiveness of a potential anti-tick vaccine with combined protection against Lyme borreliosis and tick-borne encephalitis in Slovenia.

Ticks Tick Borne Dis 2019 01 30;10(1):63-71. Epub 2018 Aug 30.

Department of Infectious Diseases, University Medical Center Ljubljana, Slovenia.

This study assessed cost-effectiveness of a potential anti-tick vaccine that would protect against both Lyme borreliosis (LB) and tick-borne encephalitis (TBE) in a highly endemic setting of Slovenia. A Markov model was developed to estimate cost-effectiveness of a vaccine with potential combined protection against LB and TBE from the societal perspective. The model expressed time in annual cycles, followed a target population through their lifetime, and applied an annual discounting of 3%. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X183017
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http://dx.doi.org/10.1016/j.ttbdis.2018.08.014DOI Listing
January 2019
18 Reads

Analyzing the protection scope limit for biosequence patent claims in China.

Authors:
Wei Li

Nat Biotechnol 2018 09;36(9):811-813

Law School of Zhejiang University of Finance and Economics, Hangzhou, China.

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http://dx.doi.org/10.1038/nbt.4234DOI Listing
September 2018
5 Reads
41.510 Impact Factor

Global Mortality From Firearms, 1990-2016.

Authors:
Mohsen Naghavi Laurie B Marczak Michael Kutz Katya Anne Shackelford Megha Arora Molly Miller-Petrie Miloud Taki Eddine Aichour Nadia Akseer Rajaa M Al-Raddadi Khurshid Alam Suliman A Alghnam Carl Abelardo T Antonio Olatunde Aremu Amit Arora Mohsen Asadi-Lari Reza Assadi Tesfay Mehari Atey Leticia Avila-Burgos Ashish Awasthi Beatriz Paulina Ayala Quintanilla Suzanne Lyn Barker-Collo Till Winfried Bärnighausen Shahrzad Bazargan-Hejazi Masoud Behzadifar Meysam Behzadifar James R Bennett Ashish Bhalla Zulfiqar A Bhutta Arebu Issa Bilal Guilherme Borges Rohan Borschmann Alexandra Brazinova Julio Cesar Campuzano Rincon Félix Carvalho Carlos A Castañeda-Orjuela Lalit Dandona Rakhi Dandona Paul I Dargan Diego De Leo Samath Dhamminda Dharmaratne Eric L Ding Huyen Phuc Do David Teye Doku Kerrie E Doyle Tim Robert Driscoll Dumessa Edessa Ziad El-Khatib Aman Yesuf Endries Alireza Esteghamati Andre Faro Farshad Farzadfar Valery L Feigin Florian Fischer Kyle J Foreman Richard Charles Franklin Nancy Fullman Neal D Futran Tsegaye Tewelde Gebrehiwot Reyna Alma Gutiérrez Nima Hafezi-Nejad Hassan Haghparast Bidgoli Gessessew Bugssa Hailu Josep Maria Haro Hamid Yimam Hassen Caitlin Hawley Delia Hendrie Martha Híjar Guoqing Hu Olayinka Stephen Ilesanmi Mihajlo Jakovljevic Spencer L James Sudha Jayaraman Jost B Jonas Amaha Kahsay Amir Kasaeian Peter Njenga Keiyoro Yousef Khader Ibrahim A Khalil Young-Ho Khang Jagdish Khubchandani Aliasghar Ahmad Kiadaliri Christian Kieling Yun Jin Kim Soewarta Kosen Kristopher J Krohn G Anil Kumar Faris Hasan Lami Van C Lansingh Heidi Jane Larson Shai Linn Raimundas Lunevicius Hassan Magdy Abd El Razek Muhammed Magdy Abd El Razek Reza Malekzadeh Deborah Carvalho Malta Amanda J Mason-Jones Richard Matzopoulos Peter T N Memiah Walter Mendoza Tuomo J Meretoja Haftay Berhane Mezgebe Ted R Miller Shafiu Mohammed Maziar Moradi-Lakeh Rintaro Mori Devina Nand Cuong Tat Nguyen Quyen Le Nguyen Dina Nur Anggraini Ningrum Felix Akpojene Ogbo Andrew T Olagunju George C Patton Michael R Phillips Suzanne Polinder Farshad Pourmalek Mostafa Qorbani Afarin Rahimi-Movaghar Vafa Rahimi-Movaghar Mahfuzar Rahman Rajesh Kumar Rai Chhabi Lal Ranabhat David Laith Rawaf Salman Rawaf Ali Rowhani-Rahbar Mahdi Safdarian Saeid Safiri Rajesh Sagar Joseph S Salama Juan Sanabria Milena M Santric Milicevic Rodrigo Sarmiento-Suárez Benn Sartorius Maheswar Satpathy David C Schwebel Soraya Seedat Sadaf G Sepanlou Masood Ali Shaikh Nigussie Tadesse Sharew Ivy Shiue Jasvinder A Singh Mekonnen Sisay Vegard Skirbekk Adauto Martins Soares Filho Dan J Stein Mark Andrew Stokes Mu'awiyyah Babale Sufiyan Mamta Swaroop Bryan L Sykes Rafael Tabarés-Seisdedos Fentaw Tadese Bach Xuan Tran Tung Thanh Tran Kingsley Nnanna Ukwaja Tommi Juhani Vasankari Vasily Vlassov Andrea Werdecker Pengpeng Ye Paul Yip Naohiro Yonemoto Mustafa Z Younis Zoubida Zaidi Maysaa El Sayed Zaki Simon I Hay Stephen S Lim Alan D Lopez Ali H Mokdad Theo Vos Christopher J L Murray

JAMA 2018 08;320(8):792-814

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

Importance: Understanding global variation in firearm mortality rates could guide prevention policies and interventions.

Objective: To estimate mortality due to firearm injury deaths from 1990 to 2016 in 195 countries and territories.

Design, Setting, And Participants: This study used deidentified aggregated data including 13 812 location-years of vital registration data to generate estimates of levels and rates of death by age-sex-year-location. Read More

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http://dx.doi.org/10.1001/jama.2018.10060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143020PMC
August 2018
26 Reads
35.290 Impact Factor

A Scoping Review of the Quality and the Design of Evaluations of Mobile Health, Telehealth, Smart Pump and Monitoring Technologies Performed in a Pharmacy-Related Setting.

Front Pharmacol 2018 26;9:678. Epub 2018 Jul 26.

Pharmaceutical Policy and Practice Research Centre, University of Huddersfield, Huddersfield, United Kingdom.

There is currently a need for high quality evaluations of new mobile health, telehealth, smart pump and monitoring technologies undertaken in a pharmacy-related setting. We aim to evaluate the use of these monitoring technologies performed in this setting. A systematic searching of English articles that examined the quality and the design of technologies conducted in pharmacy-related facilities was performed using the following databases: MEDLINE and Cumulative index to Nursing and Allied Health Literature (CINAHL) to identify original studies examining the quality and the design of technologies and published in peer-reviewed journals. Read More

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http://dx.doi.org/10.3389/fphar.2018.00678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070776PMC
July 2018
6 Reads

Prevention of Surgical Site Infections: A Systematic Review of Cost Analyses in the Use of Prophylactic Antibiotics.

Front Pharmacol 2018 18;9:776. Epub 2018 Jul 18.

Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

The preoperative phase is an important period in which to prevent surgical site infections (SSIs). Prophylactic antibiotic use helps to reduce SSI rates, leading to reductions in hospitalization time and cost. In clinical practice, besides effectiveness and safety, the selection of prophylactic antibiotic agents should also consider the evidence with regard to costs and microbiological results. Read More

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http://dx.doi.org/10.3389/fphar.2018.00776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060435PMC
July 2018
2 Reads

A report on the status of vaccination in Europe.

Vaccine 2018 08 4;36(33):4979-4992. Epub 2018 Jul 4.

GSK, Avenue Fleming 20, 1300 Wavre, Belgium.

Vaccine policy, decision processes and outcomes vary widely across Europe. The objective was to map these factors across 16 European countries by assessing (A) national vaccination strategy and implementation, (B) attributes of healthcare vaccination systems, and (C) outcomes of universal mass vaccination (UMV) as a measure of how successful the vaccination policy is. A. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.06.044DOI Listing
August 2018
9 Reads

Cost-Effectiveness Analysis of a Physician-Implemented Medication Screening Tool in Older Hospitalised Patients in Ireland.

Drugs Aging 2018 08;35(8):751-762

Pharmaceutical Care Research Group, School of Pharmacy, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland.

Background: A recent randomised controlled trial conducted in an Irish University teaching hospital that evaluated a physician-implemented medication screening tool, demonstrated positive outcomes in terms of a reduction in incident adverse drug reactions.

Objective: The present study objective was to evaluate the cost effectiveness of physicians applying this screening tool to older hospitalised patients compared with usual hospital care in the context of the earlier randomised controlled trial.

Method: We used a cost-effectiveness analysis alongside a conventional outcome analysis in a cluster randomised controlled trial. Read More

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http://dx.doi.org/10.1007/s40266-018-0564-0DOI Listing
August 2018
8 Reads

Modeling Approaches in Cost-Effectiveness Analysis of Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: An Updated Systematic Review and Recommendations for Future Economic Evaluations.

Pharmacoeconomics 2018 Oct;36(10):1223-1252

Department of Health Sciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.

Background: Numerous cost-effectiveness analyses (CEAs) of disease-modifying therapies (DMTs) for relapsing-remitting multiple sclerosis (RRMS) have been published in the last three decades. Literature reviews of the modeling methods and results from these CEAs have also been published. The last literature review that focused on modeling methods, without country or time horizon in the inclusion criteria, included studies published up to 2012. Read More

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http://dx.doi.org/10.1007/s40273-018-0683-9DOI Listing
October 2018
28 Reads
2.450 Impact Factor

Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice.

Biomed Pharmacother 2018 Oct 26;106:92-97. Epub 2018 Jun 26.

Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing, 210023, China. Electronic address:

β-amyloid deposition and neuroinflammation play a crucial part in Alzheimer's disease. Therefore, this study was designed to find the effects of 1-deoxynojirimycin (DNJ) purified from mulberry leaves on pathological deposition of Aβ peptides and neuroinflammation in senescence-accelerated-prone mouse 8 (SAMP8) mice. Compared to senescence-accelerated-resistant mouse 1 (SAMR1) mice, SAMP8 mice exhibited conspicuous declines in spatial memory abilities and brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptors (TrkB) level in hippocampus; increased Aβ deposition, β-secretase (BACE1) level, microglia activation and inflammatory factors, including interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) in the brain. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.06.106DOI Listing
October 2018
8 Reads

Simultaneous separation and determination of six arsenic species in Shiitake (Lentinus edodes) mushrooms: Method development and applications.

Food Chem 2018 Oct 13;262:134-141. Epub 2018 Apr 13.

College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

A method for simultaneously separating six arsenic (As) species was established by ultrasound-assisted extraction-anion exchange chromatography coupled with inductively coupled plasma mass spectrometry. Six As species could be well separated within 15 min when 0.3 M acetic acid and 25 mM NHHPO were used as the extraction solvent and mobile phase, respectively. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.04.036DOI Listing
October 2018
2 Reads

Vitamin B intake reduces the risk for colorectal cancer: a dose-response analysis.

Eur J Nutr 2018 May 9. Epub 2018 May 9.

Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.

Purpose: Several epidemiological studies have assessed the ability of vitamin B to prevent colorectal cancer (CRC), but the results are controversial results. We conducted a dose-response meta-analysis to investigate the association between vitamin B and CRC risk.

Methods: We searched the PubMed and EMBASE database until January 3, 2018 to identify relevant studies. Read More

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http://dx.doi.org/10.1007/s00394-018-1702-5DOI Listing
May 2018
4 Reads

Economic evaluation of prescribing conventional and newer oral anticoagulants in older adults.

Expert Rev Pharmacoecon Outcomes Res 2018 08 9;18(4):371-377. Epub 2018 May 9.

a Department of Pharmacy , University of Huddersfield , Huddersfield , United Kingdom.

Introduction: Anticoagulants refer to a variety of agents that inhibit one or more steps in the coagulation cascade. Generally, clinical conditions that require the prescribing of an oral anticoagulant increase in frequency with age. However, a major challenge of anticoagulation use among older patients is that this group of patients also experience the highest bleeding risk. Read More

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http://dx.doi.org/10.1080/14737167.2018.1474101DOI Listing
August 2018
6 Reads

Implementation of a pharmacy-managed program for the transition of chemotherapy to the outpatient setting.

Am J Health Syst Pharm 2018 May;75(9):e246-e258

Banner-University Medical Center Tucson, Tucson, AZ.

Purpose: Implementation of a pharmacy-managed program for the transition of chemotherapy to the outpatient setting is described.

Summary: The University of Arizona Cancer Center and Banner-University Medical Center Tucson are affiliated not-for-profit academic medical centers in Tucson, Arizona, whose facilities include a hospital and ambulatory care clinics that maintain 3 outpatient infusion centers. The cancer center pharmacy currently employs 25 pharmacists, with 4 clinical pharmacists serving both the inpatient and outpatient treatment sites. Read More

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http://dx.doi.org/10.2146/ajhp170138DOI Listing
May 2018
9 Reads

Cost Effectiveness of Human Papillomavirus Vaccination for Men Who have Sex with Men; Reviewing the Available Evidence.

Pharmacoeconomics 2018 Aug;36(8):929-939

Unit of PharmacoTherapy, -Epidemiology & -Economics (PTE2), Department of Pharmacy, University of Groningen, Antonius Deusinglaan 1, Building 3214, 9713 AV, Groningen, The Netherlands.

Background: Men who have sex with men require special attention for human papillomavirus vaccination given elevated infection risks and the development of, in particular, anal cancer.

Objective: Our purpose was to review the cost effectiveness of human papillomavirus vaccination for both currently vaccine-eligible and non-eligible individuals, particularly the men-who-have-sex-with-men population, and synthesize the available evidence.

Methods: We systematically searched for published articles in two main databases (PubMed and EMBASE). Read More

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http://dx.doi.org/10.1007/s40273-018-0649-yDOI Listing
August 2018
6 Reads

Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves.

Sci Rep 2018 Apr 10;8(1):5779. Epub 2018 Apr 10.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.

Despite technological advances, the survival records from longevity experiments remain the most indispensable tool in ageing-related research. A variety of interventions, including medications, genetic manipulations and calorie restriction (CR), have been demonstrated to extend the lifespan of several species. Surprisingly, few systematic studies have investigated the differences among these anti-ageing strategies using survival data. Read More

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http://dx.doi.org/10.1038/s41598-018-24146-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893623PMC
April 2018
4 Reads

An evaluation of South Africa's public-private partnership for the localisation of vaccine research, manufacture and distribution.

Health Res Policy Syst 2018 Mar 27;16(1):30. Epub 2018 Mar 27.

Department of Engineering and Technology Management, University of Pretoria, Private Bag X20, Hatfield, Pretoria, 0028, South Africa.

Background: Public-private partnerships (PPPs), widely used as a means of leveraging the skills, expertise and resources of the private sector to mutual advantage, were similarly adopted by South Africa to support public sector delivery. This study has evaluated one such partnership, namely the Biovac Institute, which was established in 2003 to cover vaccine research and development, manufacturing, and supply. The initiative was highly unusual given that it attempted to combine all three aspects in a single PPP. Read More

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http://dx.doi.org/10.1186/s12961-018-0303-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870219PMC
March 2018
2 Reads

Polyelectrolyte Complex Nanoparticles from Chitosan and Acylated Rapeseed Cruciferin Protein for Curcumin Delivery.

J Agric Food Chem 2018 Mar 27;66(11):2685-2693. Epub 2018 Feb 27.

College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing , Nanjing University of Finance and Economics , Nanjing 210023 , China.

Curcumin is a polyphenol that exhibits several biological activities, but its low aqueous solubility results in low bioavailability. To improve curcumin bioavailability, this study has focused on developing a polyelectrolyte complexation method to form layer-by-layer assembled nanoparticles, for curcumin delivery, with positively charged chitosan (CS) and negatively charged acylated cruciferin (ACRU), a rapeseed globulin. Nanoparticles (NPs) were prepared from ACRU and CS (2:1) at pH 5. Read More

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http://pubs.acs.org/doi/10.1021/acs.jafc.7b05083
Publisher Site
http://dx.doi.org/10.1021/acs.jafc.7b05083DOI Listing
March 2018
12 Reads

The Equity Impact Vaccines May Have On Averting Deaths And Medical Impoverishment In Developing Countries.

Health Aff (Millwood) 2018 02;37(2):316-324

Stéphane Verguet is an assistant professor of global health in the Department of Global Health and Population, Harvard T. H. Chan School of Public Health.

With social policies increasingly directed toward enhancing equity through health programs, it is important that methods for estimating the health and economic benefits of these programs by subpopulation be developed, to assess both equity concerns and the programs' total impact. We estimated the differential health impact (measured as the number of deaths averted) and household economic impact (measured as the number of cases of medical impoverishment averted) of ten antigens and their corresponding vaccines across income quintiles for forty-one low- and middle-income countries. Our analysis indicated that benefits across these vaccines would accrue predominantly in the lowest income quintiles. Read More

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http://dx.doi.org/10.1377/hlthaff.2017.0861DOI Listing
February 2018
10 Reads

Rationalizing the introduction and use of pharmaceutical products: The role of managed entry agreements in Central and Eastern European countries.

Health Policy 2018 03 11;122(3):230-236. Epub 2018 Jan 11.

Department of Public Health, University of Amsterdam, Amsterdam Public Health Research Institute, Meibergdreef 9, 22660, 1100 DD Amsterdam, The Netherlands.

This paper aims to provide an overview of the rationalization strategies for the introduction and use of pharmaceuticals, focusing on the role of managed entry agreements (MEA) in Central and Eastern European (CEE) countries, namely Bulgaria, the Czech Republic, Croatia, Hungary, Poland and Romania. We developed a conceptual framework on MEAs that was used as the basis for a standardized assessment questionnaire sent to country experts to capture their perceptions on their countries' rationalization strategies and MEAs. Our study shows that the main role of MEAs and other related policies embedded in the health care system is to limit the budget impact of drugs in all examined 6 countries. Read More

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http://dx.doi.org/10.1016/j.healthpol.2018.01.006DOI Listing
March 2018
12 Reads

Two-Year Follow-up Survey: Views of US Anesthesiologists About Health Care Costs and Future Practice Roles.

Anesth Analg 2018 02;126(2):611-614

From the Department of Anesthesiology and Perioperative Care, University of California, Irvine, California.

Anesthesiologists' perspectives on US health care finance reform are increasingly germane to recent policy reforms. The aim of this follow-up survey was to examine how anesthesiologists' views of health care costs and future practice roles have changed since 2014. Six thousand randomly chosen active members of the American Society of Anesthesiologists were again surveyed and were also asked several new questions regarding specialties and perioperative management. Read More

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http://dx.doi.org/10.1213/ANE.0000000000002571DOI Listing
February 2018
5 Reads

Evaluating the Changing Financial Burdens for Graduating Pharmacists.

Am J Pharm Educ 2017 Sep;81(7):5990

Northeast Ohio Medical University, Rootstown, Ohio.

To compare new practitioners in 2009 and 2014 by modeling net income from available salary, expenditure, and student loan data. A Monte Carlo simulation with probabilistic sensitivity analysis was conducted to model net income for graduating pharmacists in 2009 and 2014. Mean and standard deviations were recorded for each model parameter. Read More

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http://dx.doi.org/10.5688/ajpe8175990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663654PMC
September 2017
4 Reads

Drug Policy in Croatia.

Value Health Reg Issues 2017 Sep;13:27-30

Roche Polska, Sp. z.o.o., Warsaw, Poland.

We presented a general overview of the health care system as well as the pricing and reimbursement environment in Croatia. In Croatia, most of the public funding for health care is collected from employers, through mandatory health care contributions for all the employed citizens. This contribution is a dedicated tax reserved for the health care system derived from employees' salaries. Read More

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http://dx.doi.org/10.1016/j.vhri.2017.07.005DOI Listing
September 2017
6 Reads

Effects of polysaccharides from the base of Flammulina Velutipes stipe on growth of murine RAW264.7, B16F10 and L929 cells.

Int J Biol Macromol 2018 Feb 16;107(Pt B):2150-2156. Epub 2017 Oct 16.

College of Food Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, China. Electronic address:

A polysaccharide (FVSP) was isolated from the base of Flammuliana Velutipes stipe, and FVSP was further purified by DEAE-cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography to obtain three fractions named FVSP-1, FVSP-2 and FVSP-3. Then their activation of macrophage cell RAW 264.7 and anti-proliferative effects to the murine melanoma B16F10 and fibroblasts L929 cells were evaluated by using the cell model experiments. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2017.10.090DOI Listing
February 2018
16 Reads

Direct costs for nonsurgical management of Chronic Pancreatitis in a tertiary care teaching hospital.

Expert Rev Pharmacoecon Outcomes Res 2018 Jun 12;18(3):315-320. Epub 2017 Oct 12.

e Department of Finance and Economics , T. A. Pai Management Institute , Manipal , India.

Background: Chronic pancreatitis (CP) is a leading cause of hospitalization among gastrointestinal diseases resulting in considerable financial burden to patients. However the direct costs for nonsurgical management in CP remains unexplored.

Methods: A cross sectional study was carried out (2011-14) in the Department of Gastroenterology, Kasturba Hospital, Manipal, India. Read More

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http://dx.doi.org/10.1080/14737167.2018.1386560DOI Listing
June 2018
10 Reads
1.870 Impact Factor

It's Time to Broaden the Conversation About the Student Debt Crisis Beyond Rising Tuition Costs.

Am J Pharm Educ 2017 08;81(6):101

Pharmacy Quality Alliance (PQA, Inc.), Alexandria, Virginia.

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http://dx.doi.org/10.5688/ajpe816101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607711PMC
August 2017
1 Read

Healthcare Finance in the Kingdom of Saudi Arabia: A Qualitative Study of Householders' Attitudes.

Appl Health Econ Health Policy 2018 Feb;16(1):55-64

Economics, Finance and Entrepreneurship Group, Aston Business School, Aston University, Birmingham, UK.

Background: The public sector healthcare system in Saudi Arabia, essentially financed by oil revenues and 'free at the point of delivery', is coming under increasing strain due to escalating expenditure and an increasingly volatile oil market and is likely to be unsustainable in the medium to long term.

Objectives: This study examines how satisfied the Saudi people are with their public sector healthcare services and assesses their willingness to contribute to financing the system through a national health insurance scheme. The study also examines public preferences and expectations of a future national health insurance system. Read More

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http://dx.doi.org/10.1007/s40258-017-0353-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797208PMC
February 2018
3 Reads

The impact of an inflammatory bowel disease nurse-led biologics service.

Frontline Gastroenterol 2016 Oct 7;7(4):283-288. Epub 2016 Jul 7.

Department of Gastroenterology, Southampton General Hospital, Southampton, UK.

Introduction: Southampton General Hospital provides inflammatory bowel disease (IBD) services for a population of 650 000. Biological agents have impacted hugely on IBD but are costly drugs requiring careful supervision. These challenges led us to develop a specialist nurse-led biologics service to improve patient care. Read More

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http://dx.doi.org/10.1136/flgastro-2016-100696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369502PMC
October 2016
53 Reads

Merger mania: mergers and acquisitions in the generic drug sector from 1995 to 2016.

Global Health 2017 Aug 22;13(1):62. Epub 2017 Aug 22.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, QC, H3A 1A2, Canada.

Background: Drug shortages and increasing generic drug prices are associated with low levels of competition. Mergers and acquisitions impact the level of competition. Record merger and acquisition activity was reported for the pharmaceutical sector in 2014/15, yet information on mergers and acquisitions in the generic drug sector are absent from the literature. Read More

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http://dx.doi.org/10.1186/s12992-017-0285-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567637PMC
August 2017
4 Reads

Potential Anti-inflammatory Sesquiterpene Lactones from Eupatorium lindleyanum.

Planta Med 2018 Jan 9;84(2):123-128. Epub 2017 Aug 9.

College of food science and Engineering, Nanjing University of Finance and Economics, Nanjing, P. R. China.

has traditionally been used as folk medicine in Asian countries for its therapeutic effects on tracheitis and tonsillitis. Investigation of the anti-inflammatory active constituents from led to the isolation of two novel sesquiterpene lactones, named eupalinolide L (1: ) and eupalinolide M (2: ), and seven known sesquiterpene lactones (3: -9: ). The structures and configurations of the new compounds were determined on the basis of spectroscopic analysis, especially 2D NMR techniques. Read More

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http://dx.doi.org/10.1055/s-0043-117742DOI Listing
January 2018
11 Reads

Health insurance for patients with HIV/AIDS in Vietnam: coverage and barriers.

BMC Health Serv Res 2017 Aug 3;17(1):519. Epub 2017 Aug 3.

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Health insurance (HI) plays an important role in ensuring the financial equity by the risk pooling mechanism and reducing the economic burden of healthcare for HIV/AIDS patients. However, there is a lack of evidence to clearly understand HI coverage in regard to people living with HIV (PLWH). We conducted this study to explore the coverage and barriers of HI among PLWH in Vietnam. Read More

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http://dx.doi.org/10.1186/s12913-017-2464-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543590PMC
August 2017
36 Reads

Dietary soy isoflavones alleviate dextran sulfate sodium-induced inflammation and oxidative stress in mice.

Authors:
Bin Wang Cunbing Wu

Exp Ther Med 2017 Jul 18;14(1):276-282. Epub 2017 May 18.

Department of Food Engineering, Jiangsu Polytechnic of Finance and Economics, Huaian, Jiangsu 223005, P.R. China.

It has been hypothesized that soy isoflavones exhibit anti-oxidative and anti-inflammatory functions, however, the effects of soy isoflavones on inflammatory bowel diseases remain unknown. Therefore, the present study aimed to investigate the effect and underlying mechanism of dietary soy isoflavones on dextran sulfate sodium (DSS)-induced colitis. Mice were administered DSS and soy isoflavones, and histomorphometry, oxidative stress, inflammation and intestinal tight junctions were determined. Read More

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http://dx.doi.org/10.3892/etm.2017.4469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488499PMC
July 2017
8 Reads

Distributed Data Networks That Support Public Health Information Needs.

J Public Health Manag Pract 2017 Nov/Dec;23(6):674-683

Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (Mr Tabano); University of Colorado's Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado (Mr Tabano); AcademyHealth, Washington, District of Columbia (Ms Cole); Department of Health Care Finance, Washington, District of Columbia (Dr Holve); Denver Public Health, Denver Health, Denver, Colorado (Dr Davidson); and University of Colorado Schools of Public Health and Medicine, Aurora, Colorado (Dr Davidson).

Introduction: Data networks, consisting of pooled electronic health data assets from health care providers serving different patient populations, promote data sharing, population and disease monitoring, and methods to assess interventions. Better understanding of data networks, and their capacity to support public health objectives, will help foster partnerships, expand resources, and grow learning health systems.

Methods: We conducted semistructured interviews with 16 key informants across the United States, identified as network stakeholders based on their respective experience in advancing health information technology and network functionality. Read More

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http://dx.doi.org/10.1097/PHH.0000000000000614DOI Listing
June 2018
24 Reads