3,938 results match your criteria Journal of Periodontal Research [Journal]


Sclerostin and WNT-5a gingival protein levels in chronic periodontitis and health.

J Periodontal Res 2019 Apr 14. Epub 2019 Apr 14.

Division of Periodontology, Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota.

Background And Objective: Wnt signaling pathways regulate osteoblast differentiation and bone formation and are associated with inflammatory responses driven by innate and adaptive immunity via the NF-κB pathway. The aim of this study was to compare the levels of sclerostin (SOST), WNT-5a, and TNF-α between chronic periodontitis and periodontally healthy sites and determine their value as diagnostic markers of chronic periodontitis.

Material And Methods: In a cross-sectional assessment 25 chronic periodontitis cases and 25 periodontally healthy controls were selected upon clinical and radiographic periodontal evaluation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jre.12659
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http://dx.doi.org/10.1111/jre.12659DOI Listing
April 2019
1 Read

Cigarette smoke reduces short chain fatty acid production by a Porphyromonas gingivalis clinical isolate.

J Periodontal Res 2019 Apr 14. Epub 2019 Apr 14.

Departments of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky.

Objectives: We hypothesized that short chain fatty acid (SCFA) production by oral pathogens is suppressed by exposure to cigarette smoke extract (CSE).

Background: Tobacco smoking is a major risk factor for plaque-induced periodontal diseases. Despite increased disease susceptibility, overt oral inflammation is suppressed in smokers, presenting a diagnostic conundrum. Read More

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http://dx.doi.org/10.1111/jre.12660DOI Listing

Effects of oleanolic acid acetate on bone formation in an experimental periodontitis model in mice.

J Periodontal Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Biochemistry, School of Dentistry, IHBR, Kyungpook National University, Daegu, Korea.

Objective: We evaluated the role of oleanolic acid acetate (OAA), a triterpenoid commonly used in the treatment of liver disorders, inflammatory diseases, and metastasis, in bone formation after tooth loss by periodontitis.

Background: Periodontitis causes the sequential degradation of the alveolar bone and associated structures, resulting in tooth loss. Several studies have attempted to regenerate the bone for implantation following tooth loss. Read More

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http://dx.doi.org/10.1111/jre.12657DOI Listing

Quality of methods and reporting in association studies of chronic periodontitis and IL1A -889 and IL1B +3953/4 SNPs: A systematic review.

J Periodontal Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy.

Objective: The aim of this systematic review was to evaluate the quality of reporting and methodology in genetic association studies between IL1A -889 and IL1B +3954 polymorphisms and chronic periodontitis.

Background: Evidence provided by periodontal research on genetic risk factors is of uttermost importance in clinical practice as a possible diagnostic and prognostic tool for periodontitis. Inadequate reporting of results as well as high risk of bias due to methodological inconsistency hampers the integration of evidence in terms of clinical applicability. Read More

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http://dx.doi.org/10.1111/jre.12655DOI Listing

Genetics of Periodontitis without Bias.

J Periodontal Res 2019 Mar 21. Epub 2019 Mar 21.

Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1111/jre.12653DOI Listing
March 2019
1 Read

Self-assembling polymeric dendritic peptide as functional osteogenic matrix for periodontal regeneration scaffolds-an in vitro study.

J Periodontal Res 2019 Mar 20. Epub 2019 Mar 20.

Biomedical Technology Wing, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Thiruvananthapuram, India.

Objective: Regeneration of periodontal defects is challenging as it necessitates the formation of complex tissue structure with cementum, periodontal ligament, and alveolar bone. Rather than the conventional barrier membranes, scaffolds mimicking extracellular matrix (ECM) can achieve faster healing as they promote migration, adhesion, and differentiation of native progenitor cells. This work explores the possibility of a functional osteogenic matrix based on self-assembling peptide appended dendritic polydiacetylene in regenerating diseased periodontia. Read More

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http://dx.doi.org/10.1111/jre.12647DOI Listing

Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.

J Periodontal Res 2019 Mar 20. Epub 2019 Mar 20.

Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Background And Objective: A key factor in the modulation of angiogenesis as well as in bone resorption is angiopoietin-like 4. However, the role of angiopoietin-like 4 in periodontal tissue is unknown. Here, we hypothesized that hypoxia and the hypoxia mimetic agent L-mimosine can induce the production of angiopoietin-like 4 in periodontal fibroblasts. Read More

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http://dx.doi.org/10.1111/jre.12649DOI Listing
March 2019
1 Read

Osteogenic cells transfer improving root coverage: A randomized clinical trial.

J Periodontal Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Periodontics, School of Dentistry at Bauru, University of São Paulo, Bauru, Brazil.

Background And Objective: The aim of this interventional, parallel-assignment, single-blinded, randomized, efficacy study was to investigate the efficacy of the treatment of gingival recessions by osteogenic cell transfer. This is the first randomized clinical trial of this nature.

Material And Methods: Treatment of Miller class I or II gingival recessions >4 mm was randomly defined by casual sorting and performed by newly forming bone graft (NFBG) and coronally advanced flap (CAF) or subepithelial connective tissue graft (SCTG) and CAF (control). Read More

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http://doi.wiley.com/10.1111/jre.12651
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http://dx.doi.org/10.1111/jre.12651DOI Listing
March 2019
2 Reads

Evidence of spreading vasodilation in the human gingiva evoked by nitric oxide.

J Periodontal Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Conservative Dentistry, Semmelweis University, Budapest, Hungary.

Background And Objective: Spreading vasodilation is an important means of increasing local blood flow effectively during increased metabolic demands or in case of vascular injury. Our aim was to develop a technique proving the presence of spreading vasodilation in the human keratinized gingiva.

Methods: Local vasodilation was evoked by the application of nitric oxide (NO) donor nitroglycerin into a well, fixed 2 mm above the marginal gingiva, in 20 subjects with healthy periodontal tissue. Read More

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http://dx.doi.org/10.1111/jre.12650DOI Listing

Heat shock protein 70 dampens the inflammatory response of human PDL cells to mechanical loading in vitro.

J Periodontal Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthodontics, Dental Clinic, University of Aachen, Aachen, Germany.

Background And Objective: Previously, we demonstrated an inflammatory response of human PDL (hPDL) cells to mechanical loading. The cellular reaction was dampened by heat pre-treatment suggesting a protective role for heat shock proteins (HSP) during stress-induced ischemia. Here we explored if HSP70, which has already been documented in the pressure zone of tooth movement, might be regulatorily involved in the attenuation of the inflammatory response. Read More

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http://dx.doi.org/10.1111/jre.12648DOI Listing

Sequential application of bFGF and BMP-2 facilitates osteogenic differentiation of human periodontal ligament stem cells.

J Periodontal Res 2019 Mar 9. Epub 2019 Mar 9.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, China.

Background And Objectives: Basic fibroblast growth factor (bFGF) promotes cells proliferation and chemotaxis and maintains stemness while inhibits mineralized nodule formation. Bone morphogenetic protein 2 (BMP-2) shows great potential in promoting bone formation. However, sequential application of these two growth factors on periodontal ligament stem cells (PDLSCs) has not been explored. Read More

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http://dx.doi.org/10.1111/jre.12644DOI Listing
March 2019
1 Read

No differences in microbiome changes between anti-adhesive and antibacterial ingredients in toothpastes during periodontal therapy.

J Periodontal Res 2019 Mar 9. Epub 2019 Mar 9.

Department of Periodontology and Conservative Dentistry, Muenster University Hospital, Muenster, Germany.

Aim: This subgroup analysis of a 12-week randomized, double-blind, and two-center trial aimed to evaluate whether two different toothpaste formulations can differentially modulate the dental microbiome.

Material And Methods: Forty one mild to moderate periodontitis patients used as an adjunct to periodontal treatment either a toothpaste with anti-adhesive zinc-substituted carbonated hydroxyapatite (HA) or with antimicrobial and anti-adhesive amine fluoride/stannous fluoride (AmF/SnF ) during a 12-week period. Plaque samples from buccal/lingual, interproximal, and subgingival sites were taken at baseline, 4 weeks after oral hygiene phase, and 8 weeks after periodontal therapy. Read More

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http://dx.doi.org/10.1111/jre.12645DOI Listing

Retinol/inflammation affect stemness and differentiation potential of gingival stem/progenitor cells via Wnt/β-catenin.

J Periodontal Res 2019 Mar 4. Epub 2019 Mar 4.

Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts-University, Kiel, Germany.

Background And Objective: Inflammatory cytokines impact the course of periodontal disease, repair, and regeneration. Vitamin A and its metabolites are inflammation-modulatory biomolecules, affecting cellular pluripotency. The aim of this study was to investigate the effect of retinol and periodontal inflammatory cytokines (IL-1β/TNF-α/IFN-γ) on pluripotency and proliferative properties of gingival mesenchymal stem/progenitor cells (G-MSCs), for the first time. Read More

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http://dx.doi.org/10.1111/jre.12643DOI Listing

Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss.

J Periodontal Res 2019 Feb 25. Epub 2019 Feb 25.

Department of Oral Biology, University of Florida, Gainesville, Florida.

Background And Objective: Both chronic and aggressive periodontal disease are associated with vitamin D deficiency. The active form of vitamin D, 1,25(OH) D , induces the expression of the antimicrobial peptide LL-37 and innate immune mediators in cultured human gingival epithelial cells (GECs). The aim of this study was to further delineate the mechanism by which vitamin D enhances the innate defense against the development of periodontal disease (PD). Read More

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http://dx.doi.org/10.1111/jre.12646DOI Listing
February 2019
1 Read

Myd88 plays a major role in the keratinocyte response to infection with Porphyromonas gingivalis.

J Periodontal Res 2019 Feb 22. Epub 2019 Feb 22.

Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University-Hadassah, Jerusalem, Israel.

Aim: To explore the role of keratinocyte myeloid differentiation primary response 88 (MyD88) expression in the adhesion of Porphyromonas gingivalis to the cells and its subsequent invasion and intracellular survival.

Materials And Methods: Primary mouse keratinocytes from wild-type (WT) or Myd88 mice were infected with P gingivalis alone or co-infected with Fusobacterium nucleatum. Bacterial adhesion and invasion were measured using fluorescent microscopy and flow cytometry, and intracellular survival in keratinocytes was quantified by an antibiotic protection assay. Read More

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http://dx.doi.org/10.1111/jre.12641DOI Listing
February 2019
2 Reads

Qualitative and quantitative differences in the subgingival microbiome of the restored and unrestored teeth.

J Periodontal Res 2019 Feb 8. Epub 2019 Feb 8.

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands.

Background And Objective: Metal-based dental restorations with a subgingival outline may enhance plaque accumulation and bacterial colonization. This study aimed to investigate whether metal-based restorations influence the composition of subgingival microbiome.

Material And Methods: Per subject one site with a metal-based restoration and one contra-lateral site without a restoration were selected on basis of radiographic bone loss ≤2 mm, restoration outline at sulcus level/subgingivally, pocket depth ≤4 mm, and no root canal treatments. Read More

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http://dx.doi.org/10.1111/jre.12642DOI Listing
February 2019
1 Read

Dynamics of alveolar bone healing after the removal of orthodontic temporary anchorage devices.

J Periodontal Res 2019 Jan 24. Epub 2019 Jan 24.

Department of Orthodontics, The Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, Korea.

Objective: The aim of this study was to investigate the dynamics of alveolar bone formation and healing pattern after the removal of orthodontic temporary anchorage devices (TADs).

Methods: Miniscrews (N = 32) were inserted into the buccal inter-radicular alveolar bone in beagle dogs. Afterward, miniscrews were removed at different time points during a 13-week period and six different in vivo fluorescent markers were injected at 1, 2, 6, 8, 10, and 12 weeks. Read More

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http://dx.doi.org/10.1111/jre.12640DOI Listing
January 2019
3 Reads
2.215 Impact Factor

Is the use of Cannabis associated with periodontitis? A systematic review and meta-analysis.

J Periodontal Res 2019 Jan 24. Epub 2019 Jan 24.

Graduate Program in Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil.

Recent studies have shown that there is also biological plausibility for a possible relationship between periodontal disease and Cannabis use, thus the aim of this study was to investigate whether the use of Cannabis is associated with periodontitis. Electronic searches were performed in PubMed, Scopus, ISI-Web of Science, BVS-Virtual health library and Scielo without restrictions. Search strategy was performed using relevant keywords considering the structure of each database. Read More

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http://dx.doi.org/10.1111/jre.12639DOI Listing
January 2019
1 Read

Methodological quality and risk-of-bias assessments in systematic reviews of treatments for peri-implantitis.

J Periodontal Res 2019 Jan 22. Epub 2019 Jan 22.

Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan.

Background And Objectives: The purpose of the present study was to evaluate the methodological quality and risk of bias in systematic reviews (SRs) on the effectiveness of peri-implantitis treatments.

Material And Methods: We searched four electronic databases: MEDLINE, Web of Science, Cochrane Database of Systematic Reviews, and EMBASE. Previous SRs focusing on peri-implantitis treatment published between 2010 and 2017 were identified. Read More

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http://dx.doi.org/10.1111/jre.12638DOI Listing
January 2019
1 Read
2.215 Impact Factor

Immunohistochemical study of CD34 and podoplanin in periodontal disease.

J Periodontal Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Dentistry, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.

Background And Objective: The aim of this study was to evaluate the angiogenesis and lymphangiogenesis in gingival tissue biopsy specimens of individuals with clinically healthy gingiva, chronic gingivitis, and chronic periodontitis (n = 30 per clinical condition).

Material And Methods: Histological sections were stained using hematoxylin and eosin as well as immunohistochemically with hematopoietic progenitor cell antigen CD34 and podoplanin (PDPN) antibodies to evaluate the microvascular count, area, and perimeter of blood and lymphatic vessels, respectively.

Results: The results revealed a correlation between the microvascular count of blood and lymphatic vessels (P = 0. Read More

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http://doi.wiley.com/10.1111/jre.12635
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http://dx.doi.org/10.1111/jre.12635DOI Listing
January 2019
13 Reads

Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model.

J Periodontal Res 2019 Jan 11. Epub 2019 Jan 11.

State Key Laboratory of Military Stomatology &National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Background And Objectives: Titanium particles/ions detected in peri-implant tissues have been considered as a potential etiologic factor for crestal bone loss around oral implants. However, the definite impact of titanium wear particles on the health of surrounding structures remains undetermined. The purpose of this study was to investigate the effects of titanium particles-induced foreign body reaction on peri-implant bone level and the related mechanism by using clodronate liposomes to deplete macrophages. Read More

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http://dx.doi.org/10.1111/jre.12633DOI Listing
January 2019
3 Reads

Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes.

J Periodontal Res 2019 Jan 11. Epub 2019 Jan 11.

Discipline of Periodontology, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Background And Objective: Subjects with diabetes and periodontitis are at high risk of cardiovascular events, while the subclinical alterations of cardiac function in this cohort remain unclear. This cross-sectional study investigated the association of periodontitis with left ventricle (LV) structural and functional abnormalities in subjects with type 2 diabetes mellitus (T2DM).

Material And Methods: A total of 115 subjects with T2DM were divided into Control group (n = 32) with no or mild periodontitis, and the rest with moderate to severe chronic periodontitis (CP) were further categorized into CP-1 (n = 41) and CP-2 (n = 42) based on disease severity. Read More

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http://doi.wiley.com/10.1111/jre.12634
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http://dx.doi.org/10.1111/jre.12634DOI Listing
January 2019
20 Reads

Upregulation of free fatty acid receptors in periodontal tissues of patients with metabolic syndrome and periodontitis.

J Periodontal Res 2018 Dec 30. Epub 2018 Dec 30.

Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, South Carolina.

Background And Objective: Metabolic syndrome (MetS) exacerbates periodontitis. Since saturated fatty acid (SFA) is increased in MetS and enhances lipopolysaccharide (LPS)-induced proinflammatory cytokine expression in macrophages, it has been considered to play a role in MetS-exacerbated periodontitis. However, it remains unknown how fatty acid receptors, which mediate the interaction of cells with SFA and uptake of SFA, are expressed and regulated in the periodontal tissue. Read More

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http://dx.doi.org/10.1111/jre.12636DOI Listing
December 2018
3 Reads

Changes in characteristics of periodontal ligament stem cells in spheroid culture.

J Periodontal Res 2018 Dec 30. Epub 2018 Dec 30.

Ochanomizu University, Tokyo, Japan.

Objectives: The periodontal ligament (PDL) has important roles in maintaining homeostasis, wound healing, and regeneration of periodontal tissues by supplying stem/progenitor cells. Periodontal ligament stem cells (PDLSCs) have mesenchymal stem cell (MSC)-like characteristics and can be isolated from periodontal tissues. The aim of this study was to examine the effect of three-dimensional spheroid culture on the characteristics of PDLSCs. Read More

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http://dx.doi.org/10.1111/jre.12637DOI Listing
December 2018
2 Reads

Biological links in periodontitis and rheumatoid arthritis: Discovery via text-mining PubMed abstracts.

J Periodontal Res 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Dentistry, The University of Hong Kong, Sai Yin Pun, Hong Kong.

Background And Objective: Primary research concerning molecular pathways that link rheumatoid arthritis with periodontitis is limited. Biomedical literature data mining can offer insights into putative linkage mechanisms toward hypothesis development, based on information discovery. The aim of this study was to explore potential Periodontitis-Rheumatoid Arthritis biological links by analysing "overlapping" genes reported in biomedical abstracts. Read More

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http://dx.doi.org/10.1111/jre.12632DOI Listing
December 2018
20 Reads

Gingival fibroblasts prevent BMP-mediated osteoblastic differentiation.

J Periodontal Res 2019 Jun 3;54(3):300-309. Epub 2018 Dec 3.

Division of Tissue Engineering and Biophotonics, Dental Institute, King's College London, London, UK.

Objectives: The inhibitory action of the superficial gingival connective tissues may limit the regenerative potential of alveolar bone in periodontal therapy or dental implant applications. The aims of this study were to investigate the hypothesis that gingival fibroblasts (GF) can inhibit bone morphogenetic protein (BMP)-induced osteoblastic differentiation, to determine their expression of BMP inhibitors, and finally to determine whether reduction of these inhibitors can relieve suppression of osteoblastic differentiation.

Methods: Gingival fibroblasts were co-cultured either directly or indirectly with calvarial osteoblasts to assess alkaline phosphatase inhibitory activity, a marker of osteoblastic differentiation. Read More

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http://dx.doi.org/10.1111/jre.12631DOI Listing
June 2019
15 Reads

Microanatomical changes and biomolecular expression at the PDL-entheses during experimental tooth movement.

J Periodontal Res 2019 Jun 28;54(3):251-258. Epub 2018 Nov 28.

Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, California.

The novel aspect of this study was to contextualize the co-localization of biomolecular expression in widened and narrowed periodontal ligament (PDL)-space within a mechanically activated periodontal complex. The PDL is unique as it is the only ligament with both innervation and vascularization. Maxillary molars in 6-week-old male C57BL/6 mice (N = 5) were experimentally translated for 2 weeks using an elastic spacer. Read More

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http://doi.wiley.com/10.1111/jre.12625
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http://dx.doi.org/10.1111/jre.12625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465084PMC
June 2019
11 Reads

The therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review.

J Periodontal Res 2019 Jun 25;54(3):207-217. Epub 2018 Nov 25.

Department of Periodontology and Operative Dentistry, Faculty of Dentistry, University of Münster, Münster, Germany.

This systematic review aimed to: (a) generate a descriptive synthesis of preclinical studies assessing the therapeutic potential of regulatory T lymphocytes (Tregs) to arrest periodontitis, (b) evaluate the methodological heterogeneity of the reviewed animal studies and (c) assess the risk of bias (RoB) of the included studies. The electronic search for animal studies included the MEDLINE, EMBASE, Web of Science and LILACS databases. In addition, a manual search assessed the high-ranked scientific journals in "periodontics/immunology" and the references listed in the included studies. Read More

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http://doi.wiley.com/10.1111/jre.12629
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http://dx.doi.org/10.1111/jre.12629DOI Listing
June 2019
16 Reads

A comprehensive study on donor-matched comparisons of three types of mesenchymal stem cells-containing cells from human dental tissue.

J Periodontal Res 2019 Jun 25;54(3):286-299. Epub 2018 Nov 25.

Shandong Provincial Key Laboratory of Oral Tissue Regeneraton, School of Stomatology, Shandong University, Jinan, China.

Background And Objective: Mesenchymal stem cells (MSCs) have been widely used in tissue engineering, such as for regenerating the supporting structures of teeth destroyed by periodontal diseases. In recent decades, dental tissue-derived MSCs have drawn much attention owing to their accessibility, plasticity and applicability. Dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs) and gingival MSCs (GMSCs) are the most readily available MSCs among all types of dental MSCs. Read More

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http://dx.doi.org/10.1111/jre.12630DOI Listing
June 2019
3 Reads

Comparison between different isoelectric points of biodegradable gelatin sponges incorporating β-tricalcium phosphate and recombinant human fibroblast growth factor-2 for ridge augmentation: A preclinical study of saddle-type defects in dogs.

J Periodontal Res 2019 Jun 25;54(3):278-285. Epub 2018 Nov 25.

Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Background And Objective: It is well known that recombinant human fibroblast growth factor-2 (rhFGF-2) signaling plays an important role in tissue repair and regeneration. rhFGF-2 strongly binds to acidic gelatin via ionic linkages and is gradually released upon gelatin decomposition. On the other hand, the linkage between rhFGF-2 and basic gelatin is so weak that most rhFGF-2 is rapidly released from basic gelatin by simple desorption. Read More

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http://doi.wiley.com/10.1111/jre.12628
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http://dx.doi.org/10.1111/jre.12628DOI Listing
June 2019
15 Reads
2.215 Impact Factor

Assessment of microRNA-144-5p and its putative targets in inflamed gingiva from chronic periodontitis patients.

J Periodontal Res 2019 Jun 18;54(3):266-277. Epub 2018 Nov 18.

Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background And Objective: This study aimed to discover the distinctive MicroRNAs (miRNA) functioning in the pathogenesis of periodontal inflammation, which might be potential therapy targets of chronic periodontitis.

Material And Methods: miRNA profiles of human inflamed gingival tissue from three previous microarrays were re-analysed. Gingival tissues were collected for the validation of overlapping miRNAs, and a network was constructed to show regulatory connection between overlapping miRNAs and periodontitis-associated target genes. Read More

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http://doi.wiley.com/10.1111/jre.12627
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http://dx.doi.org/10.1111/jre.12627DOI Listing
June 2019
11 Reads

Healing differences in narrow diameter implants submitted to immediate and conventional loading in mandibular overdentures: A randomized clinical trial.

J Periodontal Res 2019 Jun 19;54(3):241-250. Epub 2018 Nov 19.

Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Brazil.

Background: Biological responses to different loading protocols during the bone healing phase in subjects with long time since edentulism, rehabilitated with narrow diameter implants (NDIs) to retain mandibular overdentures (MOs), are still unavailable.

Objective: This randomized clinical trial compared the peri-implant health, implant stability, and concentrations of pro- and anti-inflammatory cytokines in the peri-implant crevicular fluid (PICF) in mandibular edentulous patients under conventional (CL) and immediate loading (IML) during healing.

Methodology: Twenty totally edentulous patients received two NDIs (2. Read More

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http://doi.wiley.com/10.1111/jre.12624
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http://dx.doi.org/10.1111/jre.12624DOI Listing
June 2019
16 Reads

Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non-coronary heart diseases.

J Periodontal Res 2019 Jun 18;54(3):259-265. Epub 2018 Nov 18.

Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Objective: The aim of this clinical trial was to assess the relationship between periodontal bacterial burden and coronary heart disease (CHD) in Japanese population.

Background: Many epidemiological reports suggest that periodontitis is a risk factor for CHD; however, the influence of each periodontal bacterium and periodontal condition in Japanese CHD patients is unclear.

Methods: We studied 897 patients with cardiovascular diseases in Tokyo Medical and Dental University Hospital from May 2012 to August 2015. Read More

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http://doi.wiley.com/10.1111/jre.12626
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http://dx.doi.org/10.1111/jre.12626DOI Listing
June 2019
15 Reads

Surface damage of dental implant systems and ions release after exposure to fluoride and hydrogen peroxide.

J Periodontal Res 2019 Feb 22;54(1):46-52. Epub 2018 Oct 22.

Center for Microelectromechanical Systems (CMEMS-UMINHO), University of Minho, Guimarães, Portugal.

Objective: The aim of this study was to evaluate surface changes on dental implant systems and ions release after immersion in fluoride and hydrogen peroxide.

Methods: Ten implant-abutment assemblies were embedded in acrylic resin and cross-sectioned along the implant vertical axis. Samples were wet ground and polished. Read More

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http://doi.wiley.com/10.1111/jre.12603
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http://dx.doi.org/10.1111/jre.12603DOI Listing
February 2019
6 Reads

Protein and mRNA detection of classic cytokines in corresponding samples of serum, gingival tissue and gingival crevicular fluid from subjects with periodontitis.

J Periodontal Res 2019 Apr 26;54(2):174-179. Epub 2018 Oct 26.

Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, Brazil.

Background And Objective: Little is known about the correspondence of cytokines detected among the different biological matrices used in periodontal research and whether locally-detected cytokine mRNA can also be identified at the translated protein level. The aims of this study were to compare: (a) the detection of classic cytokines at protein level in corresponding samples of serum, gingival tissue and gingival crevicular fluid (GCF) in subjects with periodontitis and (b) the detection of cytokines at protein level in GCF and tissue with their detection at mRNA level in tissue.

Material And Methods: Protein concentrations of IL-1β, IL-6 and TNF-α were measured in corresponding samples of GCF, gingival tissue and serum from 125 subjects with chronic periodontitis by multiplex immunoassay. Read More

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http://doi.wiley.com/10.1111/jre.12617
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http://dx.doi.org/10.1111/jre.12617DOI Listing
April 2019
4 Reads

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation.

J Periodontal Res 2019 Jun 22;54(3):225-232. Epub 2018 Oct 22.

Dental Research Division, School of Dentistry, Paulista University, São Paulo, São Paulo, Brazil.

Objectives: This study aimed at investigating the effect of the systemic administration of resveratrol (RESV) on oxidative stress during experimental periodontitis in rats subjected to cigarette smoke inhalation.

Material And Methods: Experimental periodontitis (EP) was induced in 26 male Wistar rats by the insertion of a ligature around one of the first mandibular and maxillary molars. The animals were assigned randomly to the following groups: cigarette smoke inhalation (CSI; 3 times/d, 8 minutes/d) + resveratrol (10 mg/Kg), that is, SMK + RESV (n = 13) and cigarette smoke inhalation + placebo, that is, SMK + PLAC (n = 13). Read More

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http://dx.doi.org/10.1111/jre.12622DOI Listing
June 2019
3 Reads

Improved RANKL expression and osteoclastogenesis induction of CD27+CD38- memory B cells: A link between B cells and alveolar bone damage in periodontitis.

J Periodontal Res 2019 Feb 22;54(1):73-80. Epub 2018 Oct 22.

Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang, China.

Background And Objective: Periodontitis is a bacteria-induced disease that often leads to alveolar bone damage. Its mechanisms were considered to be complicated, involving an imbalance of the formation and resorption of bone. We sought to disclose the antibody-independent function of B cells during periodontitis. Read More

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http://dx.doi.org/10.1111/jre.12606DOI Listing
February 2019
1 Read

Periodontitis, periodontal inflammation, and mild cognitive impairment: A 5-year cohort study.

J Periodontal Res 2019 Jun 21;54(3):233-240. Epub 2018 Oct 21.

Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan.

Background And Objectives: Identification of modifiable factors for mild cognitive impairment (MCI) is important since individuals with MCI are at a high risk of dementia and disability. Previous studies have suggested a potential association between periodontitis and cognitive impairment, but the results remain inconclusive. We designed a 5-year longitudinal study to explore the association between MCI and periodontitis and periodontal inflammation in older adults. Read More

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http://doi.wiley.com/10.1111/jre.12623
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http://dx.doi.org/10.1111/jre.12623DOI Listing
June 2019
11 Reads

Assessment of microRNA-146a in generalized aggressive periodontitis and its association with disease severity.

J Periodontal Res 2019 Feb 17;54(1):27-32. Epub 2018 Oct 17.

Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Objective: MicroRNA-146a (miR-146a) is a small noncoding RNA that plays a critical role in the negative regulation of the innate immune response, and the dysregulation of miR-146a has been associated with several inflammatory disorders. In generalized aggressive periodontitis (GAgP) the degree of clinical inflammation appears to be similar to that of chronic periodontitis, and, in this situation, age of onset and family history are important additional criteria for diagnosis. This study was performed to evaluate the level of miR-146a expressed in gingival tissues of patients with GAgP and its association with disease severity. Read More

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http://doi.wiley.com/10.1111/jre.12538
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http://dx.doi.org/10.1111/jre.12538DOI Listing
February 2019
2 Reads

Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis.

J Periodontal Res 2019 Jun 10;54(3):199-206. Epub 2018 Oct 10.

Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

To identify the genetic risk factors for aggressive periodontitis (AgP), it is important to understand the progression and pathogenesis of AgP. The purpose of this review was to summarize the genetic risk factors for AgP identified through a case-control genomewide association study (GWAS) and replication study. The initial studies to identify novel AgP risk factors were potentially biased because they relied on previous studies. Read More

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http://dx.doi.org/10.1111/jre.12620DOI Listing
June 2019
1 Read

Characterization and comparison of neutrophil extracellular traps in gingival samples of periodontitis and gingivitis: A pilot study.

J Periodontal Res 2019 Jun 8;54(3):218-224. Epub 2018 Oct 8.

Periodontology Department, School of Dentistry, University of Granada, Granada, Spain.

Background And Objective: Neutrophil extracellular traps (NETs) are a recently discovered antimicrobial mechanism used by neutrophils that have been proposed as an intervention in the pathogenesis of periodontitis. The objective of our study was to characterize the expression of NETs in gingival tissues with periodontitis and controls and to compare the expression of these traps in gingival tissue samples of patients with gingivitis and periodontitis.

Material And Methods: An observational cross-sectional study was conducted on patients with periodontitis, gingivitis, and controls that needed tooth extraction. Read More

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http://dx.doi.org/10.1111/jre.12621DOI Listing
June 2019
2 Reads

Periodontal ligament-associated protein-1 gets involved in experimental periodontitis.

J Periodontal Res 2019 Apr 8;54(2):180-189. Epub 2018 Oct 8.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, China.

Background And Objective: Periodontal ligament-associated protein-1 (PLAP-1) is an important regulator of osteogenic differentiation of periodontal ligament cells and plays important role in the homeostasis of periodontal tissues. But the role of PLAP-1 in periodontitis is poorly understood. Expressions of PLAP-1 in experimental periodontitis are observed to elucidate whether PLAP-1 gets involved in the pathogenesis of periodontitis. Read More

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http://doi.wiley.com/10.1111/jre.12618
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http://dx.doi.org/10.1111/jre.12618DOI Listing
April 2019
4 Reads

Is dietary melatonin supplementation a viable adjunctive therapy for chronic periodontitis?-A randomized controlled clinical trial.

J Periodontal Res 2019 Apr 8;54(2):190-197. Epub 2018 Oct 8.

Department of Periodontology and Oral Medicine, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

Background And Objective: Melatonin is synthesized naturally by pineal gland and responsible for regulation of sleep/waking cycle. It showed appreciated anti-inflammatory and antioxidant properties. The aim of this randomized clinical trial (RCT) was to assess the additive effect of melatonin supplementation in insomniac individuals with generalized chronic periodontitis (gCP) after scaling and root planing (SRP). Read More

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http://dx.doi.org/10.1111/jre.12619DOI Listing
April 2019
10 Reads

Label-free quantitative proteomic analysis of human periodontal ligament stem cells by high-resolution mass spectrometry.

J Periodontal Res 2019 Feb 8;54(1):53-62. Epub 2018 Oct 8.

Department of Periodontology, College of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea.

Background And Objectives: Proteome analysis of periodontal ligament stem cells (PDLSCs) could be used to study the function of PDL tissue. We used a label-free quantitative proteomic technique to investigate differentially expressed proteins (DEPs) in human PDLSCs (hPDLSCs) compared to human bone marrow mesenchymal stem cells (hBMSCs) and identify proteins specific to hPDLSCs.

Material And Methods: hPDLSCs (n = 3) and hBMSCs (n = 3) were cultured and harvested for protein extraction and trypsin digestion. Read More

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http://dx.doi.org/10.1111/jre.12604DOI Listing
February 2019
1 Read

A novel IkB kinase inhibitor attenuates ligature-induced periodontal disease in mice.

J Periodontal Res 2019 Apr 8;54(2):164-173. Epub 2018 Oct 8.

Department of Periodontology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

Backgrounds And Objectives: IMD-0354 is a novel I kappa-B kinase (IKK) inhibitor, which regulates inflammation. The purpose of this study was to examine the effect of the reagent on bone loss for ligature-induced periodontitis.

Material And Methods: We ligated around the upper right second molars of 8-week-old C57BL/6J mice in the split-mouth model. Read More

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http://doi.wiley.com/10.1111/jre.12615
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http://dx.doi.org/10.1111/jre.12615DOI Listing
April 2019
13 Reads

The periodontal stem/progenitor cell inflammatory-regenerative cross talk: A new perspective.

J Periodontal Res 2019 Apr 8;54(2):81-94. Epub 2018 Oct 8.

Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany.

Adult multipotent stem/progenitor cells, with remarkable regenerative potential, have been isolated from various components of the human periodontium. These multipotent stem/progenitor cells include the periodontal ligament stem/progenitor cells (PDLSCs), stem cells from the apical papilla (SCAP), the gingival mesenchymal stem/progenitor cells (G-MSCs), and the alveolar bone proper stem/progenitor cells (AB-MSCs). Whereas inflammation is regarded as the reason for tissue damage, it also remains a fundamental step of any early healing process. Read More

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http://doi.wiley.com/10.1111/jre.12616
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http://dx.doi.org/10.1111/jre.12616DOI Listing
April 2019
4 Reads

Vitamin D attenuates human gingival fibroblast inflammatory cytokine production following advanced glycation end product interaction with receptors for AGE.

J Periodontal Res 2019 Apr 8;54(2):154-163. Epub 2018 Oct 8.

College of Dentistry, The University of Tennessee Health Science Center, Memphis, Tennessee.

Background And Objectives: Vitamin D [1,25(OH) D or 1,25D3] is critical in musculoskeletal health, inflammation, immune response, and glucose metabolism. Patients with vitamin D deficiency may be at higher risk of diabetes and periodontitis. Diabetic patients exhibit exacerbated inflammation and more periodontal destruction. Read More

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http://dx.doi.org/10.1111/jre.12613DOI Listing
April 2019
2 Reads

Interleukin-10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies.

J Periodontal Res 2019 Apr 8;54(2):95-105. Epub 2018 Oct 8.

Department of Periodontology, Tianjin Stomatological Hospital, Nankai University, Tianjin, China.

The purpose of the meta-analysis was to investigate the potential association of interleukin-10 (IL-10) polymorphisms with susceptibility to chronic periodontitis (CP). A total of 33 studies involving 3487 cases and 4356 controls were identified through a search of multiple electronic databases (last search was updated on 19 July 2018). Three single nucleotide polymorphisms (SNPs) were included in the meta-analysis: -1082A>G(rs1800896), -819C>T(rs1800871), and -592C>A(rs1800872). Read More

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http://doi.wiley.com/10.1111/jre.12612
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http://dx.doi.org/10.1111/jre.12612DOI Listing
April 2019
3 Reads

A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population.

J Periodontal Res 2018 Dec 4;53(6):992-998. Epub 2018 Oct 4.

Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.

Background And Objective: Periodontitis in one of the most prevalent dental diseases. Despite numerous studies have investigated its aetiopathogenetic factors, few works have focused on its genetic predisposition and most of them took into account only candidate genes. Therefore, we conducted a Genome Wide Association Study in an Italian isolated population aimed at uncovering genetic variants that predispose to this disorder. Read More

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http://dx.doi.org/10.1111/jre.12598DOI Listing
December 2018
2 Reads