3,913 results match your criteria Journal of Periodontal Research [Journal]


Biological links in periodontitis and rheumatoid arthritis: Discovery via text-mining PubMed abstracts.

J Periodontal Res 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Dentistry, The University of Hong Kong, Sai Yin Pun, Hong Kong.

Background And Objective: Primary research concerning molecular pathways that link rheumatoid arthritis with periodontitis is limited. Biomedical literature data mining can offer insights into putative linkage mechanisms toward hypothesis development, based on information discovery. The aim of this study was to explore potential Periodontitis-Rheumatoid Arthritis biological links by analysing "overlapping" genes reported in biomedical abstracts. Read More

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http://dx.doi.org/10.1111/jre.12632DOI Listing
December 2018
1 Read

Gingival fibroblasts prevent BMP-mediated osteoblastic differentiation.

J Periodontal Res 2018 Dec 3. Epub 2018 Dec 3.

Division of Tissue Engineering and Biophotonics, Dental Institute, King's College London, London, UK.

Objectives: The inhibitory action of the superficial gingival connective tissues may limit the regenerative potential of alveolar bone in periodontal therapy or dental implant applications. The aims of this study were to investigate the hypothesis that gingival fibroblasts (GF) can inhibit bone morphogenetic protein (BMP)-induced osteoblastic differentiation, to determine their expression of BMP inhibitors, and finally to determine whether reduction of these inhibitors can relieve suppression of osteoblastic differentiation.

Methods: Gingival fibroblasts were co-cultured either directly or indirectly with calvarial osteoblasts to assess alkaline phosphatase inhibitory activity, a marker of osteoblastic differentiation. Read More

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http://dx.doi.org/10.1111/jre.12631DOI Listing
December 2018
4 Reads

Microanatomical changes and biomolecular expression at the PDL-entheses during experimental tooth movement.

J Periodontal Res 2018 Nov 28. Epub 2018 Nov 28.

Division of Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, California.

The novel aspect of this study was to contextualize the co-localization of biomolecular expression in widened and narrowed periodontal ligament (PDL)-space within a mechanically activated periodontal complex. The PDL is unique as it is the only ligament with both innervation and vascularization. Maxillary molars in 6-week-old male C57BL/6 mice (N = 5) were experimentally translated for 2 weeks using an elastic spacer. Read More

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http://doi.wiley.com/10.1111/jre.12625
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http://dx.doi.org/10.1111/jre.12625DOI Listing
November 2018
6 Reads

The therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review.

J Periodontal Res 2018 Nov 25. Epub 2018 Nov 25.

Department of Periodontology and Operative Dentistry, Faculty of Dentistry, University of Münster, Münster, Germany.

This systematic review aimed to: (a) generate a descriptive synthesis of preclinical studies assessing the therapeutic potential of regulatory T lymphocytes (Tregs) to arrest periodontitis, (b) evaluate the methodological heterogeneity of the reviewed animal studies and (c) assess the risk of bias (RoB) of the included studies. The electronic search for animal studies included the MEDLINE, EMBASE, Web of Science and LILACS databases. In addition, a manual search assessed the high-ranked scientific journals in "periodontics/immunology" and the references listed in the included studies. Read More

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http://doi.wiley.com/10.1111/jre.12629
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http://dx.doi.org/10.1111/jre.12629DOI Listing
November 2018
5 Reads

A comprehensive study on donor-matched comparisons of three types of mesenchymal stem cells-containing cells from human dental tissue.

J Periodontal Res 2018 Nov 25. Epub 2018 Nov 25.

Shandong Provincial Key Laboratory of Oral Tissue Regeneraton, School of Stomatology, Shandong University, Jinan, China.

Background And Objective: Mesenchymal stem cells (MSCs) have been widely used in tissue engineering, such as for regenerating the supporting structures of teeth destroyed by periodontal diseases. In recent decades, dental tissue-derived MSCs have drawn much attention owing to their accessibility, plasticity and applicability. Dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs) and gingival MSCs (GMSCs) are the most readily available MSCs among all types of dental MSCs. Read More

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http://dx.doi.org/10.1111/jre.12630DOI Listing
November 2018
1 Read

Comparison between different isoelectric points of biodegradable gelatin sponges incorporating β-tricalcium phosphate and recombinant human fibroblast growth factor-2 for ridge augmentation: A preclinical study of saddle-type defects in dogs.

J Periodontal Res 2018 Nov 25. Epub 2018 Nov 25.

Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Background And Objective: It is well known that recombinant human fibroblast growth factor-2 (rhFGF-2) signaling plays an important role in tissue repair and regeneration. rhFGF-2 strongly binds to acidic gelatin via ionic linkages and is gradually released upon gelatin decomposition. On the other hand, the linkage between rhFGF-2 and basic gelatin is so weak that most rhFGF-2 is rapidly released from basic gelatin by simple desorption. Read More

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http://doi.wiley.com/10.1111/jre.12628
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http://dx.doi.org/10.1111/jre.12628DOI Listing
November 2018
6 Reads
2.215 Impact Factor

Assessment of microRNA-144-5p and its putative targets in inflamed gingiva from chronic periodontitis patients.

J Periodontal Res 2018 Nov 18. Epub 2018 Nov 18.

Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background And Objective: This study aimed to discover the distinctive MicroRNAs (miRNA) functioning in the pathogenesis of periodontal inflammation, which might be potential therapy targets of chronic periodontitis.

Material And Methods: miRNA profiles of human inflamed gingival tissue from three previous microarrays were re-analysed. Gingival tissues were collected for the validation of overlapping miRNAs, and a network was constructed to show regulatory connection between overlapping miRNAs and periodontitis-associated target genes. Read More

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http://doi.wiley.com/10.1111/jre.12627
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http://dx.doi.org/10.1111/jre.12627DOI Listing
November 2018
3 Reads

Healing differences in narrow diameter implants submitted to immediate and conventional loading in mandibular overdentures: A randomized clinical trial.

J Periodontal Res 2018 Nov 19. Epub 2018 Nov 19.

Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, Brazil.

Background: Biological responses to different loading protocols during the bone healing phase in subjects with long time since edentulism, rehabilitated with narrow diameter implants (NDIs) to retain mandibular overdentures (MOs), are still unavailable.

Objective: This randomized clinical trial compared the peri-implant health, implant stability, and concentrations of pro- and anti-inflammatory cytokines in the peri-implant crevicular fluid (PICF) in mandibular edentulous patients under conventional (CL) and immediate loading (IML) during healing.

Methodology: Twenty totally edentulous patients received two NDIs (2. Read More

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http://doi.wiley.com/10.1111/jre.12624
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http://dx.doi.org/10.1111/jre.12624DOI Listing
November 2018
3 Reads

Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non-coronary heart diseases.

J Periodontal Res 2018 Nov 18. Epub 2018 Nov 18.

Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Objective: The aim of this clinical trial was to assess the relationship between periodontal bacterial burden and coronary heart disease (CHD) in Japanese population.

Background: Many epidemiological reports suggest that periodontitis is a risk factor for CHD; however, the influence of each periodontal bacterium and periodontal condition in Japanese CHD patients is unclear.

Methods: We studied 897 patients with cardiovascular diseases in Tokyo Medical and Dental University Hospital from May 2012 to August 2015. Read More

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http://doi.wiley.com/10.1111/jre.12626
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http://dx.doi.org/10.1111/jre.12626DOI Listing
November 2018
2 Reads

Surface damage of dental implant systems and ions release after exposure to fluoride and hydrogen peroxide.

J Periodontal Res 2018 Oct 22. Epub 2018 Oct 22.

Center for Microelectromechanical Systems (CMEMS-UMINHO), University of Minho, Guimarães, Portugal.

Objective: The aim of this study was to evaluate surface changes on dental implant systems and ions release after immersion in fluoride and hydrogen peroxide.

Methods: Ten implant-abutment assemblies were embedded in acrylic resin and cross-sectioned along the implant vertical axis. Samples were wet ground and polished. Read More

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http://doi.wiley.com/10.1111/jre.12603
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http://dx.doi.org/10.1111/jre.12603DOI Listing
October 2018
4 Reads

Protein and mRNA detection of classic cytokines in corresponding samples of serum, gingival tissue and gingival crevicular fluid from subjects with periodontitis.

J Periodontal Res 2018 Oct 26. Epub 2018 Oct 26.

Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, Brazil.

Background And Objective: Little is known about the correspondence of cytokines detected among the different biological matrices used in periodontal research and whether locally-detected cytokine mRNA can also be identified at the translated protein level. The aims of this study were to compare: (a) the detection of classic cytokines at protein level in corresponding samples of serum, gingival tissue and gingival crevicular fluid (GCF) in subjects with periodontitis and (b) the detection of cytokines at protein level in GCF and tissue with their detection at mRNA level in tissue.

Material And Methods: Protein concentrations of IL-1β, IL-6 and TNF-α were measured in corresponding samples of GCF, gingival tissue and serum from 125 subjects with chronic periodontitis by multiplex immunoassay. Read More

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http://dx.doi.org/10.1111/jre.12617DOI Listing
October 2018

Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation.

J Periodontal Res 2018 Oct 22. Epub 2018 Oct 22.

Dental Research Division, School of Dentistry, Paulista University, São Paulo, São Paulo, Brazil.

Objectives: This study aimed at investigating the effect of the systemic administration of resveratrol (RESV) on oxidative stress during experimental periodontitis in rats subjected to cigarette smoke inhalation.

Material And Methods: Experimental periodontitis (EP) was induced in 26 male Wistar rats by the insertion of a ligature around one of the first mandibular and maxillary molars. The animals were assigned randomly to the following groups: cigarette smoke inhalation (CSI; 3 times/d, 8 minutes/d) + resveratrol (10 mg/Kg), that is, SMK + RESV (n = 13) and cigarette smoke inhalation + placebo, that is, SMK + PLAC (n = 13). Read More

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http://dx.doi.org/10.1111/jre.12622DOI Listing
October 2018

Improved RANKL expression and osteoclastogenesis induction of CD27+CD38- memory B cells: A link between B cells and alveolar bone damage in periodontitis.

J Periodontal Res 2018 Oct 22. Epub 2018 Oct 22.

Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang, China.

Background And Objective: Periodontitis is a bacteria-induced disease that often leads to alveolar bone damage. Its mechanisms were considered to be complicated, involving an imbalance of the formation and resorption of bone. We sought to disclose the antibody-independent function of B cells during periodontitis. Read More

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http://dx.doi.org/10.1111/jre.12606DOI Listing
October 2018

Periodontitis, periodontal inflammation, and mild cognitive impairment: A 5-year cohort study.

J Periodontal Res 2018 Oct 21. Epub 2018 Oct 21.

Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan.

Background And Objectives: Identification of modifiable factors for mild cognitive impairment (MCI) is important since individuals with MCI are at a high risk of dementia and disability. Previous studies have suggested a potential association between periodontitis and cognitive impairment, but the results remain inconclusive. We designed a 5-year longitudinal study to explore the association between MCI and periodontitis and periodontal inflammation in older adults. Read More

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http://doi.wiley.com/10.1111/jre.12623
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http://dx.doi.org/10.1111/jre.12623DOI Listing
October 2018
7 Reads

Assessment of microRNA-146a in generalized aggressive periodontitis and its association with disease severity.

J Periodontal Res 2018 Oct 17. Epub 2018 Oct 17.

Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Objective: MicroRNA-146a (miR-146a) is a small noncoding RNA that plays a critical role in the negative regulation of the innate immune response, and the dysregulation of miR-146a has been associated with several inflammatory disorders. In generalized aggressive periodontitis (GAgP) the degree of clinical inflammation appears to be similar to that of chronic periodontitis, and, in this situation, age of onset and family history are important additional criteria for diagnosis. This study was performed to evaluate the level of miR-146a expressed in gingival tissues of patients with GAgP and its association with disease severity. Read More

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http://doi.wiley.com/10.1111/jre.12538
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http://dx.doi.org/10.1111/jre.12538DOI Listing
October 2018
1 Read

Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis.

J Periodontal Res 2018 Oct 10. Epub 2018 Oct 10.

Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

To identify the genetic risk factors for aggressive periodontitis (AgP), it is important to understand the progression and pathogenesis of AgP. The purpose of this review was to summarize the genetic risk factors for AgP identified through a case-control genomewide association study (GWAS) and replication study. The initial studies to identify novel AgP risk factors were potentially biased because they relied on previous studies. Read More

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http://dx.doi.org/10.1111/jre.12620DOI Listing
October 2018

Characterization and comparison of neutrophil extracellular traps in gingival samples of periodontitis and gingivitis: A pilot study.

J Periodontal Res 2018 Oct 8. Epub 2018 Oct 8.

Periodontology Department, School of Dentistry, University of Granada, Granada, Spain.

Background And Objective: Neutrophil extracellular traps (NETs) are a recently discovered antimicrobial mechanism used by neutrophils that have been proposed as an intervention in the pathogenesis of periodontitis. The objective of our study was to characterize the expression of NETs in gingival tissues with periodontitis and controls and to compare the expression of these traps in gingival tissue samples of patients with gingivitis and periodontitis.

Material And Methods: An observational cross-sectional study was conducted on patients with periodontitis, gingivitis, and controls that needed tooth extraction. Read More

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http://dx.doi.org/10.1111/jre.12621DOI Listing
October 2018

Periodontal ligament-associated protein-1 gets involved in experimental periodontitis.

J Periodontal Res 2018 Oct 8. Epub 2018 Oct 8.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, China.

Background And Objective: Periodontal ligament-associated protein-1 (PLAP-1) is an important regulator of osteogenic differentiation of periodontal ligament cells and plays important role in the homeostasis of periodontal tissues. But the role of PLAP-1 in periodontitis is poorly understood. Expressions of PLAP-1 in experimental periodontitis are observed to elucidate whether PLAP-1 gets involved in the pathogenesis of periodontitis. Read More

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http://doi.wiley.com/10.1111/jre.12618
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http://dx.doi.org/10.1111/jre.12618DOI Listing
October 2018
1 Read

Is dietary melatonin supplementation a viable adjunctive therapy for chronic periodontitis?-A randomized controlled clinical trial.

J Periodontal Res 2018 Oct 8. Epub 2018 Oct 8.

Department of Periodontology and Oral Medicine, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

Background And Objective: Melatonin is synthesized naturally by pineal gland and responsible for regulation of sleep/waking cycle. It showed appreciated anti-inflammatory and antioxidant properties. The aim of this randomized clinical trial (RCT) was to assess the additive effect of melatonin supplementation in insomniac individuals with generalized chronic periodontitis (gCP) after scaling and root planing (SRP). Read More

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http://dx.doi.org/10.1111/jre.12619DOI Listing
October 2018
6 Reads

Label-free quantitative proteomic analysis of human periodontal ligament stem cells by high-resolution mass spectrometry.

J Periodontal Res 2018 Oct 8. Epub 2018 Oct 8.

Department of Periodontology, College of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea.

Background And Objectives: Proteome analysis of periodontal ligament stem cells (PDLSCs) could be used to study the function of PDL tissue. We used a label-free quantitative proteomic technique to investigate differentially expressed proteins (DEPs) in human PDLSCs (hPDLSCs) compared to human bone marrow mesenchymal stem cells (hBMSCs) and identify proteins specific to hPDLSCs.

Material And Methods: hPDLSCs (n = 3) and hBMSCs (n = 3) were cultured and harvested for protein extraction and trypsin digestion. Read More

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http://dx.doi.org/10.1111/jre.12604DOI Listing
October 2018

A novel IkB kinase inhibitor attenuates ligature-induced periodontal disease in mice.

J Periodontal Res 2018 Oct 8. Epub 2018 Oct 8.

Department of Periodontology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

Backgrounds And Objectives: IMD-0354 is a novel I kappa-B kinase (IKK) inhibitor, which regulates inflammation. The purpose of this study was to examine the effect of the reagent on bone loss for ligature-induced periodontitis.

Material And Methods: We ligated around the upper right second molars of 8-week-old C57BL/6J mice in the split-mouth model. Read More

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http://doi.wiley.com/10.1111/jre.12615
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http://dx.doi.org/10.1111/jre.12615DOI Listing
October 2018
9 Reads

The periodontal stem/progenitor cell inflammatory-regenerative cross talk: A new perspective.

J Periodontal Res 2018 Oct 8. Epub 2018 Oct 8.

Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany.

Adult multipotent stem/progenitor cells, with remarkable regenerative potential, have been isolated from various components of the human periodontium. These multipotent stem/progenitor cells include the periodontal ligament stem/progenitor cells (PDLSCs), stem cells from the apical papilla (SCAP), the gingival mesenchymal stem/progenitor cells (G-MSCs), and the alveolar bone proper stem/progenitor cells (AB-MSCs). Whereas inflammation is regarded as the reason for tissue damage, it also remains a fundamental step of any early healing process. Read More

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http://doi.wiley.com/10.1111/jre.12616
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http://dx.doi.org/10.1111/jre.12616DOI Listing
October 2018
1 Read

Vitamin D attenuates human gingival fibroblast inflammatory cytokine production following advanced glycation end product interaction with receptors for AGE.

J Periodontal Res 2018 Oct 8. Epub 2018 Oct 8.

College of Dentistry, The University of Tennessee Health Science Center, Memphis, Tennessee.

Background And Objectives: Vitamin D [1,25(OH) D or 1,25D3] is critical in musculoskeletal health, inflammation, immune response, and glucose metabolism. Patients with vitamin D deficiency may be at higher risk of diabetes and periodontitis. Diabetic patients exhibit exacerbated inflammation and more periodontal destruction. Read More

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http://dx.doi.org/10.1111/jre.12613DOI Listing
October 2018

Interleukin-10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies.

J Periodontal Res 2018 Oct 8. Epub 2018 Oct 8.

Department of Periodontology, Tianjin Stomatological Hospital, Nankai University, Tianjin, China.

The purpose of the meta-analysis was to investigate the potential association of interleukin-10 (IL-10) polymorphisms with susceptibility to chronic periodontitis (CP). A total of 33 studies involving 3487 cases and 4356 controls were identified through a search of multiple electronic databases (last search was updated on 19 July 2018). Three single nucleotide polymorphisms (SNPs) were included in the meta-analysis: -1082A>G(rs1800896), -819C>T(rs1800871), and -592C>A(rs1800872). Read More

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http://doi.wiley.com/10.1111/jre.12612
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http://dx.doi.org/10.1111/jre.12612DOI Listing
October 2018
1 Read

A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population.

J Periodontal Res 2018 Dec 4;53(6):992-998. Epub 2018 Oct 4.

Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.

Background And Objective: Periodontitis in one of the most prevalent dental diseases. Despite numerous studies have investigated its aetiopathogenetic factors, few works have focused on its genetic predisposition and most of them took into account only candidate genes. Therefore, we conducted a Genome Wide Association Study in an Italian isolated population aimed at uncovering genetic variants that predispose to this disorder. Read More

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http://dx.doi.org/10.1111/jre.12598DOI Listing
December 2018

Probiotics alter the immune response of gingival epithelial cells challenged by Porphyromonas gingivalis.

J Periodontal Res 2018 Oct 4. Epub 2018 Oct 4.

Division of Periodontics, Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Background And Objective: Although previous studies revealed the potential use of probiotics in the control of periodontitis, little is known about their interactions with gingival epithelial cells (GECs). Since GECs comprise the first defense in the subgingival microenvironment, the aim of this study was to evaluate the effect of probiotic lactobacilli and bifidobacteria strains on OBA-9 cells challenged with Porphyromonas gingivalis.

Methods: Immortalized human GECs (OBA-9) were challenged with live P. Read More

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http://doi.wiley.com/10.1111/jre.12608
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http://dx.doi.org/10.1111/jre.12608DOI Listing
October 2018
8 Reads

Association of LTA gene haploblock with periodontal disease in Italian adults.

J Periodontal Res 2018 Oct 4. Epub 2018 Oct 4.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Background: Periodontitis is a common oral disease caused by host inflammatory response towards bacteria biofilm. The chronic activation of immune response leads to destruction of teeth supporting tissue, bone loss and tooth detachment. Different factors could be involved in the development and severity of the disease; among them the host genetic background should be considered. Read More

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http://dx.doi.org/10.1111/jre.12609DOI Listing
October 2018

R-spondin 2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/β-catenin signaling pathway.

J Periodontal Res 2018 Oct 4. Epub 2018 Oct 4.

Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Objective: In this study, we measured the expression of R-spondin 2 (RSPO2) in periodontal ligament (PDL) tissue and cells. Further, we examined the effects of RSPO2 on osteoblastic differentiation of immature human PDL cells (HPDLCs).

Background: R-spondin (RSPO) family proteins are secreted glycoproteins that play important roles in embryonic development and tissue homeostasis through activation of the Wnt/β-catenin signaling pathway. Read More

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http://doi.wiley.com/10.1111/jre.12611
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http://dx.doi.org/10.1111/jre.12611DOI Listing
October 2018
1 Read

Periodontal disease susceptible matrilines in the Cayo Santiago Macaca mulatta macaques.

J Periodontal Res 2018 Sep 11. Epub 2018 Sep 11.

Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky.

Objective And Background: The expression of periodontitis, including age of onset, extent, and severity is considered to represent an interaction of the individual's oral microbiome and host response to the microbial challenge that is modified by both genetics and environmental factors. The aim of this study was to determine the distribution of periodontitis in a population of nonhuman primates, to document features of familial distribution that could reflect heritability and transmission of microbes with enhanced virulence.

Material And Methods: This report presents our findings from evaluation of periodontal disease bone defects in skulls from 569 animals (5-31 years of age) derived from the skeletons of the rhesus monkeys (Macaca mulatta) of Cayo Santiago derived from eight matrilines over 6-9 generations. Read More

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http://doi.wiley.com/10.1111/jre.12610
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http://dx.doi.org/10.1111/jre.12610DOI Listing
September 2018
4 Reads

Activity of two hyaluronan preparations on primary human oral fibroblasts.

J Periodontal Res 2018 Sep 27. Epub 2018 Sep 27.

Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.

Background And Objective: The potential benefit of using hyaluronan (HA) in reconstructive periodontal surgery is still a matter of debate. The aim of the present study was to evaluate the effects of two HA formulations on human oral fibroblasts involved in soft tissue wound healing/regeneration.

Material And Methods: Metabolic, proliferative and migratory abilities of primary human palatal and gingival fibroblasts were examined upon HA treatment. Read More

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http://doi.wiley.com/10.1111/jre.12602
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http://dx.doi.org/10.1111/jre.12602DOI Listing
September 2018
7 Reads

Smoking habit modulates peri-implant microbiome: A case-control study.

J Periodontal Res 2018 Dec 26;53(6):983-991. Epub 2018 Sep 26.

Dental Research Division, School of Dentistry, Paulista University, São Paulo, SP, Brazil.

Background And Objective: Smoking is a recognized risk factor for peri-implant disease and leads to microbiological changes in mucositis and peri-implantitis. However, there is no knowledge about the impact of smoking in healthy peri-implant tissue. The aim of the study was to evaluate the microbiome in a peri-implant environment in smokers with healthy peri-implant conditions. Read More

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http://dx.doi.org/10.1111/jre.12597DOI Listing
December 2018

Strontium ion attenuates lipopolysaccharide-stimulated proinflammatory cytokine expression and lipopolysaccharide-inhibited early osteogenic differentiation of human periodontal ligament cells.

J Periodontal Res 2018 Dec 17;53(6):999-1008. Epub 2018 Sep 17.

Department of Oral Implantology, Yantai Stomatological Hospital, Yantai, China.

Background And Objective: Periodontitis is a chronic inflammatory disease characterized by the destruction of the periodontium. The strontium ion (Sr ) can prevent the bone loss associated with periodontitis and promote the regeneration of the bone. The mechanisms by which the Sr works remain poorly understood. Read More

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http://doi.wiley.com/10.1111/jre.12599
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http://dx.doi.org/10.1111/jre.12599DOI Listing
December 2018
6 Reads

Developmental pathways of periodontal tissue regeneration: Developmental diversities of tooth morphogenesis do also map capacity of periodontal tissue regeneration?

Authors:
Ugo Ripamonti

J Periodontal Res 2018 Sep 12. Epub 2018 Sep 12.

Bone Research Laboratory, School of Oral Health Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Nothing is known on the impact of developmental divergence on periodontal tissue regeneration in vertebrate animals. Molecularly, the induction of tooth morphogenesis is highly conserved deploying across animal phyla a constant and reproducible set of gene pathways, which result in morphogenesis of multiple odontode forms and shapes. Genetic mutations positively affect animal speciation via evolving biting and masticatory forces as well as dietary habits selectively imprinted in animal phyla during evolutionary speciation. Read More

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http://dx.doi.org/10.1111/jre.12596DOI Listing
September 2018

Strontium enhances proliferation and osteogenic behavior of periodontal ligament cells in vitro.

J Periodontal Res 2018 Dec 12;53(6):1020-1028. Epub 2018 Sep 12.

Department of Dentistry and Oral Health, Faculty of Health, Aarhus University, Aarhus, Denmark.

Background And Objective: Strontium (Sr) enhances osteogenic differentiation of certain multipotent cells. Periodontal ligament cells (PDLCs) are known to be multipotent, and Sr might be useful in periodontal bone tissue engineering. This study investigates the effect of high concentration of Sr on the proliferation and osteogenic behavior of PDLCs in vitro. Read More

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http://dx.doi.org/10.1111/jre.12601DOI Listing
December 2018

Periodontal condition and levels of bacteria associated with periodontitis in individuals with bipolar affective disorders: A case-control study.

J Periodontal Res 2018 Sep 12. Epub 2018 Sep 12.

Federal University of Minas Gerais, Belo Horizonte, Brazil.

Objective: To evaluate the epidemiological and microbiological aspects of the potential association between bipolar affective disorder (BAPD) and periodontitis.

Methodology: The present case-control study comprised 176 individuals with BAPD and 176 controls. All individuals underwent a complete full-mouth periodontal examination and microbiological sampling. Read More

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http://dx.doi.org/10.1111/jre.12605DOI Listing
September 2018

The effect of liraglutide on the proliferation, migration, and osteogenic differentiation of human periodontal ligament cells.

J Periodontal Res 2018 Sep 12. Epub 2018 Sep 12.

School of Stomatology, Lanzhou University, Lanzhou, China.

Objective: Liraglutide (LIRA) is a novel antidiabetic therapy that may have anti-inflammatory and bone protective effects. Thus, we studied the potential therapeutic effect of LIRA on periodontitis by assessing the effects of LIRA on the proliferation, migration, inflammation, and osteogenic differentiation of human periodontal ligament cells (hPDLCs) after LPS stimulation.

Material And Methods: The expression of glucagon like-peptide 1 receptor (GLP-1R) was measured using qRT-PCR. Read More

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http://doi.wiley.com/10.1111/jre.12607
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http://dx.doi.org/10.1111/jre.12607DOI Listing
September 2018
6 Reads

Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats.

J Periodontal Res 2018 Dec 30;53(6):1009-1019. Epub 2018 Aug 30.

Department of Periodontology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, Japan.

Background And Objective: Theaflavins (TFs), the major polyphenol in black tea, have the ability to reduce inflammation and bone resorption. The aim of this study was to evaluate the effects of TFs on experimental periodontitis in rats.

Material And Methods: Thirty rats were divided into five groups: Control (glycerol application without ligation), Ligature (glycerol application with ligation), TF1 (1 mg/mL TF application with ligation), TF10 (10 mg/mL TF application with ligation), and TF100 (100 mg/mL TF application with ligation). Read More

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http://dx.doi.org/10.1111/jre.12600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221153PMC
December 2018
6 Reads

Environmental lead effects on gene expression in oral epithelial cells.

J Periodontal Res 2018 Dec 26;53(6):961-971. Epub 2018 Aug 26.

Center for Oral Health Research and Division of Periodontology, College of Dentistry, University of Kentucky, Lexington, Kentucky.

Background And Objective: Host responses in periodontitis span a range of local and emigrating cell types and biomolecules. Accumulating evidence regarding the expression of this disease across the population suggests some component of genetic variation that controls onset and severity of disease, in concert with the qualitative and quantitative parameters of the oral microbiome at sites of disease. However, there remains little information regarding the capacity of accruing environmental stressors or modifiers over a lifespan at both the host genetic and microbial ecology levels to understand fully the population variation in disease. Read More

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http://dx.doi.org/10.1111/jre.12594DOI Listing
December 2018
6 Reads

Morphological characterization of para- and proinflammatory neutrophil phenotypes using transmission electron microscopy.

J Periodontal Res 2018 Dec 5;53(6):972-982. Epub 2018 Aug 5.

Matrix Dynamics Group, Department of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Background And Objective: Bacterial challenge is constant in the oral cavity. To contain the commensal biofilm, partly activated neutrophils are continuously recruited as part of a normal physiologic process, without exposing the host to the harmful effect of a fully active neutrophil response. This intermediate immune state has been termed para-inflammation, as opposed to the fully activated proinflammatory state in oral disease. Read More

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http://dx.doi.org/10.1111/jre.12595DOI Listing
December 2018
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An orally administered oral pathobiont and commensal have comparable and innocuous systemic effects in germ-free mice.

J Periodontal Res 2018 Dec 26;53(6):950-960. Epub 2018 Jul 26.

Research Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background And Objectives: We recently proposed a novel mechanism linking periodontitis and systemic diseases, in which orally administered Porphyromonas gingivalis affects gut microbiota composition and subsequently leads to systemic inflammation. However, the mechanism by which P. gingivalis generates systemic effects from the gut is unknown. Read More

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http://dx.doi.org/10.1111/jre.12593DOI Listing
December 2018

Effect of orthodontic force associated with cigarette smoke inhalation in healthy and diseased periodontium. A histometric and immunohistochemistry analysis in rats.

J Periodontal Res 2018 Oct 25;53(5):924-931. Epub 2018 Jul 25.

Department of Diagnosis and Surgery, Division of Periodontology, College of Dentistry - ICT, São Paulo State University (UNESP), São José dos Campos, Brazil.

Background: The aim of the present study is to evaluate the effect of orthodontic forces in healthy or diseased periodontium of rats submitted/not submitted to cigarette smoke inhalation.

Material And Methods: Fifty-six male Wistar rats were allocated into two groups of conditions: smoking and non-smoking. Each group was divided into the following subgroups: control (C), orthodontic tooth movement (OTM), ligature-induced periodontitis (P) and P+OTM (POTM), with n = 14 each. Read More

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http://dx.doi.org/10.1111/jre.12584DOI Listing
October 2018
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Three-dimensional ultrastructural analysis and histomorphometry of collagen bundles in the periodontal ligament using focused ion beam/scanning electron microscope tomography.

J Periodontal Res 2018 Jul 23. Epub 2018 Jul 23.

Division of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, Kurume, Japan.

Background And Objective: The periodontal ligament (PDL) is an essential tissue for tooth function. However, the 3-dimensional ultrastructure of these PDL collagen bundles on a mesoscale is not clear. We investigated the 3-dimensional ultrastructure of these collagen bundles and quantitatively analyzed their histomorphometry using focused ion beam/scanning electron microscope (FIB/SEM) tomography. Read More

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http://dx.doi.org/10.1111/jre.12592DOI Listing

From manual periodontal probing to digital 3-D imaging to endoscopic capillaroscopy: Recent advances in periodontal disease diagnosis.

J Periodontal Res 2018 Jul 4. Epub 2018 Jul 4.

Department of Periodontics, The Dental College of Georgia at Augusta University, Augusta, GA, USA.

Deepened periodontal pockets exert a significant pathological burden on the host and its immune system, particularly in a patient with generalized moderate to severe periodontitis. This burden is extensive and longitudinal, occurring over decades of disease development. Considerable diagnostic and prognostic successes in this regard have come from efforts to measure the depths of the pockets and their contents, including level of inflammatory mediators, cellular exudates and microbes; however, the current standard of care for measuring these pockets, periodontal probing, is an analog technology in a digital age. Read More

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http://dx.doi.org/10.1111/jre.12585DOI Listing
July 2018
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Matrix metalloproteinase-7 in periodontitis with type 2 diabetes mellitus.

J Periodontal Res 2018 Oct 4;53(5):916-923. Epub 2018 Jul 4.

Department of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland.

Background And Objective: Elevated levels of matrix metalloproteinase-7 (MMP7) have been observed in serum samples of subjects with type 2 diabetes mellitus (T2DM) and in gingival tissues of subjects with periodontitis. The aim of the present study was to collect in vivo and in silico evidence on the role of MMP7 in the interplay between T2DM and generalized periodontitis (GP).

Material And Methods: The extent of MMP7 expression and localization were immunohistochemically analyzed in gingival tissues of patients with GP with T2DM (T2DM/GP, n = 11), systemically healthy patients with GP (n = 7), and systemically and periodontally healthy controls (n = 11). Read More

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http://dx.doi.org/10.1111/jre.12583DOI Listing
October 2018

Analysis of metabolic profiles of generalized aggressive periodontitis.

J Periodontal Res 2018 Oct 4;53(5):894-901. Epub 2018 Jul 4.

Department of Periodontology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background And Objective: The specific pathogenesis of generalized aggressive periodontitis (GAgP) has not yet been clarified, and few studies have focused on the association between GAgP and metabolomics. To elucidate the roles of metabolic profiles in the status of GAgP, this study aimed to identify the differential metabolic profiles between patients with GAgP and healthy controls using an untargeted metabolomic profiling method.

Material And Methods: Serum and gingival crevicular fluid samples were collected from healthy controls (n = 20) and patients with GAgP (n = 20) in this cross-sectional study. Read More

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http://doi.wiley.com/10.1111/jre.12579
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http://dx.doi.org/10.1111/jre.12579DOI Listing
October 2018
10 Reads

Prevalence, extent and severity of peri-implant diseases. A cross-sectional study based on a university setting in Brazil.

J Periodontal Res 2018 Oct 1;53(5):910-915. Epub 2018 Jul 1.

Department of Dentistry, State University of Maringá, Maringá, PR, Brazil.

Background And Objective: Peri-implant diseases are a growing concern among clinicians. Epidemiological studies following recently recommended case definitions for peri-implant diseases are emerging worldwide. Although a small number of studies on the prevalence of peri-implant diseases has been conducted in Brazil, no information on the extent and severity of the condition has been made available so far. Read More

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http://dx.doi.org/10.1111/jre.12582DOI Listing
October 2018

Consanguinity increases the risk for aggressive periodontitis.

Authors:
M Çalışır

J Periodontal Res 2018 Oct 26;53(5):902-909. Epub 2018 Jun 26.

Department of Periodontology, Faculty of Dentistry, Adiyaman University, Adiyaman, Turkey.

Background And Objective: Genetic predisposition is an important factor for developing aggressive periodontitis (AgP); however, previous studies only focused on individual families where consanguineous marriages have not been considered. Thus, there is a debate in the understanding of the genetic features of this disease. The present study aims to compare the genetic features of AgP in individuals with and without history of consanguineous marriages. Read More

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http://dx.doi.org/10.1111/jre.12580DOI Listing
October 2018
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Urokinase-plasminogen activator protects periodontal ligament fibroblast from oxidative induced-apoptosis and DNA damage.

J Periodontal Res 2018 Oct 19;53(5):861-869. Epub 2018 Jun 19.

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Science, Tehran, Iran.

Background And Objective: Urokinase-plasminogen activator (uPA) is a serine protease expressed at high basal level in normal gingival cervical fluid. Despite its known pathologic role in tissue proteolysis in periodontitis, little is known concerning uPA physiological function in oral tissue. Recent evidence in cancer cells has implicated the uPA system in DNA repair and anti-apoptotic pathways. Read More

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http://dx.doi.org/10.1111/jre.12576DOI Listing
October 2018

Spheroid culture enhances osteogenic potential of periodontal ligament mesenchymal stem cells.

J Periodontal Res 2018 Oct 14;53(5):870-882. Epub 2018 Jun 14.

Division of Periodontology, Department of Oral Function, Kyushu Dental University, Kitakyushu, Japan.

Objective And Background: Human periodontal ligament mesenchymal stem cells (hPDLMSCs) are reported to be responsible for homeostasis and regeneration of periodontal tissue. Although hPDLMSCs are commonly cultured in monolayers, monolayer cultures have been reported as inferior to 3-dimensional cultures such as spheroids, which are spherical clusters of cells formed by self-assembly. The aim of this study was to examine the osteogenic phenotype of spheroids of hPDLMSCs, compared with monolayer cultures of hPDLMSC, in vitro and in vivo. Read More

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http://dx.doi.org/10.1111/jre.12577DOI Listing
October 2018
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Interaction between the Wnt/β-catenin signaling pathway and the EMMPRIN/MMP-2, 9 route in periodontitis.

J Periodontal Res 2018 Oct 14;53(5):842-852. Epub 2018 Jun 14.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.

Background And Objectives: In periodontitis, the Wnt/β-catenin signaling pathway is related to the metabolism of the alveolar bone; further, extracellular matrix metalloproteinase inducer (EMMPRIN) expression is correlated with matrix metalloproteinases (MMPs) expression and inflammation severity. The aim of this study was to perform a preliminary investigation of the interaction between the Wnt/β-catenin signaling pathway and the EMMPRIN/MMPs route in periodontitis.

Material And Methods: Chronic periodontitis and healthy gingival tissues were obtained to detect the expression of Wnt3a, β-catenin, EMMPRIN and MMP-2, 9 by using immunohistochemical analysis. Read More

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http://dx.doi.org/10.1111/jre.12574DOI Listing
October 2018
3 Reads