5,169 results match your criteria Journal of Perinatology[Journal]


Who's counting? Assessing the effects of a simulation-based training intervention on the accuracy of neonatal heart rate auscultation.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.

Objective: To determine if simulation-based medical education could improve pediatric residents' ability to accurately assess neonatal heart rate via auscultation.

Study Design: Primary outcomes included heart rate accuracy and Neonatal Resuscitation Program (NRP) group accuracy, defined as whether a heart rate estimation fell in the appropriate NRP algorithm group. Pediatric residents completed a pre-assessment and then participated in a simulation training intervention on high-fidelity manikins. Read More

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http://dx.doi.org/10.1038/s41372-019-0339-4DOI Listing
February 2019

Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Medical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO removal while potentially reducing the risk of ventilator-induced lung injury.

Objective: To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.

Study Design: Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO). Read More

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http://dx.doi.org/10.1038/s41372-019-0338-5DOI Listing
February 2019

Health literacy of parents of very preterm infants at NICU admission and discharge: a prospective cohort study.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objective: To determine the prevalence of limited health literacy in parents of infants born ≤32 and 0/7 weeks and if health literacy changes during hospitalization.

Study Design: Multi-site, prospective cohort study measuring health literacy using the Parent Health Literacy Activities Test, which estimates caregivers' ability to complete tasks such as reading prescription labels and preparing bottles. Data were analyzed using parametric and nonparametric comparison tests and multivariable regression to control for confounders. Read More

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http://dx.doi.org/10.1038/s41372-019-0340-yDOI Listing
February 2019

The Relationship between blood pressure parameters and left ventricular output in neonates.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Paediatrics, University of Toronto, Toronto, ON, Canada.

Objective: To evaluate the relationship between systolic (SBP), diastolic (DBP), mean (MBP) blood pressures and pulse pressure (PP), and left ventricular output (LVO), a surrogate of systemic blood flow.

Study Design: This retrospective study included neonates who underwent targeted neonatal echocardiography (TNE) in 3-tertiary NICUs over 2 years. Associations between LVO and BP components were investigated. Read More

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http://dx.doi.org/10.1038/s41372-019-0337-6DOI Listing
February 2019

Is early caffeine therapy safe and effective for ventilated preterm infants?

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/s41372-019-0336-7DOI Listing
February 2019

Comparison of early postnatal prediction models for survival in congenital diaphragmatic hernia.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Objective: To compare the PF-PCO equation-partial pressure of arterial oxygen (PaO)/fraction of inspired oxygen (FiO) minus partial pressure of carbon dioxide (PCO)-to three other tools for postnatal prediction of survival in infants with congenital diaphragmatic hernia (CDH).

Study Design: A retrospective analysis of 203 infants with CDH from 1 January 2003 to 30 June 2018. Area under the curve (AUC) analysis was performed for survival and secondary outcomes of survival without extracorporeal membrane oxygenation support (ECMO) and death despite ECMO. Read More

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http://dx.doi.org/10.1038/s41372-019-0335-8DOI Listing
February 2019

Placental findings among newborns with hypoxic ischemic encephalopathy.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Women & Infants Hospital of Rhode Island, Providence, RI, USA.

Objective: To determine if pre-specified placental abnormalities among newborns with hypoxic-ischemic encephalopathy (HIE) differ compared to newborns admitted to a NICU without encephalopathy.

Study Design: Retrospective case-control study of newborns with HIE (2006-2014) and controls matched for birth year, gestational age, weight, and gender. One pathologist reviewed archived placental sections using pre-specified criteria. Read More

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http://dx.doi.org/10.1038/s41372-019-0334-9DOI Listing
February 2019

Differential effects of the retinopathy of prematurity exam on the physiology of premature infants.

J Perinatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.

Objective: To compare the differential effects of the retinopathy of prematurity (ROP) examination on the physiology of premature infants with and without oxygen support.

Study Design: We collected data from 42 premature infants (room air = 19, oxygen support = 23) and compared physiological metrics including heart rate (HR), systemic peripheral saturation (SpO), mesenteric tissue oxygen saturation (StO) and clinical events (oxygen desaturation episodes, bradycardia events, and gastric residuals).

Results: We found significant differences between groups in HR during and briefly after the exam, and in mesenteric StO during eye drop administration, eye exam, and up to 8 min after the exam. Read More

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http://dx.doi.org/10.1038/s41372-019-0331-zDOI Listing
February 2019

Tidal volume transmission during non-synchronized nasal intermittent positive pressure ventilation via RAM cannula.

J Perinatol 2019 Feb 12. Epub 2019 Feb 12.

University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Nasal intermittent positive pressure ventilation (NIPPV) is a widely used mode of support in neonates, during which ventilator inflations may or may not coincide with spontaneous breathing.

Objective: We tested the hypothesis that inflations delivered with NIPPV via RAM cannula and not accompanied by patient effort produce minimal tidal volume as measured by respiratory inductance plethysmography.

Design/methods: Fourteen subjects were monitored while receiving NIPPV. Read More

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http://dx.doi.org/10.1038/s41372-019-0333-xDOI Listing
February 2019

Outcomes of preterm infants conceived with in vitro fertilization.

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

The Center for Research, Education, Quality and Safety, MEDNAX National Medical Group, Sunrise, FL, USA.

Objectives: To determine if there is increased risk of prematurity-related complications for in vitro fertilization (IVF)-conceived preterm infants compared to matched controls.

Study Design: Cohort study of 23-34 weeks' preterm infants from 329 US NICUs discharged from 2009 to 2016. Each IVF patient was matched to three controls. Read More

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http://www.nature.com/articles/s41372-019-0332-y
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http://dx.doi.org/10.1038/s41372-019-0332-yDOI Listing
February 2019
8 Reads

Feeding during transfusion and the risk of necrotizing enterocolitis in preterm infants.

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

Carman and Ann Department of Pediatrics, Department of Pediatrics, Hutzel Women's Hospital, 3980 John R Rd, Detroit, MI, 48201, USA.

Objective: To evaluate the effect of withholding feeds during transfusion on transfusion associated acute gut injury (TRAGI).

Study Design: Data were collected on 125 preterm infants before and after the practice of withholding feeds for 12-24 h during transfusion was instituted. Logistic regression was used to examine effects of withholding feeds on TRAGI rates. Read More

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http://dx.doi.org/10.1038/s41372-019-0328-7DOI Listing
February 2019

Histological chorioamnionitis at term according to labor onset: a prospective controlled study.

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Obstetrics & Gynecology, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, the Edith Wolfson Medical Center, Holon, Israel.

Objective: To study the incidence of histological chorioamnionitis (HCA) in term pregnancies according to labor onset.

Study Design: During 2013-6, term pregnancy placentas were prospectively sent to histopathology evaluation, and compared between patients with spontaneous onset labor, pre-labor ROM, labor induction and elective cesarean deliveries.

Results: A total of 260 placentas were obtained, 65 from each group. Read More

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http://dx.doi.org/10.1038/s41372-019-0327-8DOI Listing
February 2019
1 Read

Association of chorioamnionitis and its duration with neonatal morbidity and mortality.

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.

Objective: To investigate the association of chorioamnionitis, and secondarily its duration, on neonatal adverse outcomes for infants born <34 weeks vs. ≥34 weeks.

Study Design: A secondary analyss from the observational U. Read More

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http://dx.doi.org/10.1038/s41372-019-0322-0DOI Listing
February 2019
2 Reads

Association of antenatal depression with oxidative stress and impact on spontaneous preterm birth.

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Objective: To determine whether antenatal depression is associated with oxidative stress and inflammation, and secondarily, whether the association between antenatal depression and spontaneous preterm birth (SPTB) is mediated by these biomarkers.

Study Design: The primary outcome included urine oxidative stress biomarkers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane and plasma inflammatory biomarkers measured at 10, 18, and 26 weeks and averaged within individual. Linear and logistic regression models were used, adjusting for age, race, parity, and pre-pregnancy body mass index. Read More

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http://dx.doi.org/10.1038/s41372-019-0317-xDOI Listing
February 2019
1 Read

Aletheia-20 unconcealed observations from quality improvement and evidence-based medicine.

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

Professor of Pediatrics, Baylor College of Medicine, Section Head and Service Chief of Neonatology, Texas Children's Hospital, 6621 Fannin, Suite W6104, Houston, TX, 77030, USA.

Quality improvement (QI) and evidence-based medicine (EBM) activities ideally generate value (benefit/cost). Physicians and hospitals vary in ability to demonstrate efficiency despite common methodology available to all. Based upon our 60-some years of combined QI and EBM experience, we suggest reasoned consideration of meta-cognition-thinking about thinking. Read More

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http://dx.doi.org/10.1038/s41372-019-0330-0DOI Listing
February 2019

Umbilical cord milking reduces the risk of intraventricular hemorrhage in preterm infants born before 32 weeks of gestation.

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

Division of Neonatology, University and Polytechnic Hospital La Fe, Valencia, Spain.

Objective: Intraventricular hemorrhage (IVH) is a common complication in extremely preterm infants. We aimed to demonstrate that umbilical cord milking (UCM) would reduce the incidence of IVH in this at risk population.

Study Design: We compared the incidence of IVH in a prospective cohort of consecutively born preterm infants <32 weeks' gestation receiving UCM (n = 33) with a historical cohort that underwent immediate cord clamping (ICC) (n = 36). Read More

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http://dx.doi.org/10.1038/s41372-019-0329-6DOI Listing
February 2019
1 Read

Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit.

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Pediatrics, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.

Objective: To determine frequency of hospital-acquired viral respiratory infections (HA-VRI) and associated outcomes in a NICU.

Study Design: Prospective cohort study conducted from 4 October 2016 to 21 March 2017. Infants hospitalized from birth in the NICU had a weekly nasal swab collected for testing using a multiplex PCR assay capable of detecting 16 different respiratory viruses. Read More

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http://dx.doi.org/10.1038/s41372-019-0318-9DOI Listing
February 2019
1 Read

Probiotics for preterm infants: A National Retrospective Cohort Study.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada.

Objective: To evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants.

Study Design: We conducted a retrospective cohort study of infants < 29 weeks' gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. Read More

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http://dx.doi.org/10.1038/s41372-019-0315-zDOI Listing
January 2019

Should we target higher or lower oxygen saturation targets in the preterm infant?

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics Division of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center at Oklahoma City, PO Box 26901, 1200 Everett Drive, 7th Floor North Pavilion, Oklahoma, OK, 73104, USA.

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http://dx.doi.org/10.1038/s41372-019-0325-xDOI Listing
January 2019

Sutureless closure: a versatile treatment for the diverse presentations of gastroschisis.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

Division of Pediatric Surgery, University of Virginia, Charlottesville, VA, USA.

Objective: Case series have demonstrated sutureless closures to be safe for the correction of gastroschisis. We hypothesize that sutureless closure is efficacious in patients requiring silo reduction without need for intubation.

Study Design: We conducted a retrospective case control study of infants who underwent gastroschisis repair at our institution (January 2011-August 2018). Read More

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http://www.nature.com/articles/s41372-019-0321-1
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http://dx.doi.org/10.1038/s41372-019-0321-1DOI Listing
January 2019
4 Reads

Response to Dr. Kumar's letter.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

Thomas Jefferson University, Philadelphia, PA, 19107, USA.

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http://dx.doi.org/10.1038/s41372-019-0326-9DOI Listing
January 2019

Early onset sepsis calculator-based management of newborns exposed to maternal intrapartum fever: a cost benefit analysis.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

University of Southern California Leonard D. Schaeffer Center for Health Policy & Economics, Los Angeles, CA, USA.

Objective: To determine potential net monetary benefit of an early onset sepsis calculator-based approach for management of neonates exposed to maternal intrapartum fever, compared to existing guidelines.

Study Design: We performed a cost-benefit analysis comparing two management approaches for newborns >34 weeks gestational age exposed to maternal intrapartum fever. Probabilities of sepsis and meningitis, consequences of infection and antibiotic use, direct medical costs, and indirect costs for long-term disability and mortality were considered. Read More

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http://dx.doi.org/10.1038/s41372-019-0316-yDOI Listing
January 2019
1 Read

Vasa previa and extreme prematurity: a population-based study.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

March of Dimes Prematurity Research Center at Stanford University School of Medicine, Stanford, CA, USA.

Objective: To determine population-based risks of preterm birth associated with vasa previa.

Study Design: Included were 945,950 singleton, live birth cesarean deliveries with and without vasa previa (gestational ages 24-41 weeks) in California between 2007 and 2012. Odds ratios (ORs) of preterm birth were estimated using logistic regression. Read More

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http://dx.doi.org/10.1038/s41372-019-0319-8DOI Listing
January 2019

Neuroimaging and Bayley-III correlates of early hand function in extremely preterm children.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Stanford University, Palo Alto, CA, USA.

Objective(s): Investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (CUS) and near-term brain MRI (ntMRI), and Bayley-III scores in extremely preterm (EPT) toddlers.

Study Design: Cohort analysis of Neonatal Research Network SUPPORT NEURO data. Associations between brain abnormalities, hand function, and Bayley-III scores were examined using chi-square and generalized linear mixed effect model analyses. Read More

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http://dx.doi.org/10.1038/s41372-019-0314-0DOI Listing
January 2019

Intravenous compared with oral iron for the treatment of iron-deficiency anemia in pregnancy: a systematic review and meta-analysis.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Obstetrics & Gynecology, Indiana University School of Medicine, 550N. University Boulevard, UH 2440, Indianapolis, IN, 46202, USA.

Objective: To assess the effect of intravenous versus oral iron on hematologic indices and clinical outcomes for iron-deficiency anemia (IDA) in pregnancy.

Study Design: Searches in Ovid Medline, Embase, SCOPUS, Cochrane Database, and ClinicalTrials.gov identified randomized-controlled trials comparing intravenous to oral iron for treating IDA in pregnancy. Read More

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http://dx.doi.org/10.1038/s41372-019-0320-2DOI Listing
January 2019
1 Read

Elevated umbilical cord arterial lactate at birth and electronic fetal monitoring characteristics on admission and in the active phase.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Objective: To investigate the association between elevated umbilical arterial lactate at birth and electronic fetal monitoring (EFM) characteristics at admission and in the beginning of the active phase of labor.

Study Design: Nested case-control study within a prospective cohort of laboring patients at term who achieved active labor. Neonates with umbilical arterial lactate ≥ 4 mmol/L (cases, n = 119), were matched 1:1 to controls with lactate < 4 mmol/L. Read More

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http://dx.doi.org/10.1038/s41372-019-0324-yDOI Listing
January 2019

Data electronically extracted from the electronic health record require validation.

J Perinatol 2019 Jan 24. Epub 2019 Jan 24.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objectives: Determine sources of error in electronically extracted data from electronic health records.

Study Design: Categorical and continuous variables related to early-onset neonatal hypoglycemia were preselected and electronically extracted from records of 100 randomly selected neonates within 3479 births with laboratory-proven early-onset hypoglycemia. Extraction language was written by an information technologist and data validated by blinded manual chart review. Read More

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http://dx.doi.org/10.1038/s41372-018-0311-8DOI Listing
January 2019

Umbilical cord milking in asphyxiated neonates: ethical dilemmas.

Authors:
Jogender Kumar

J Perinatol 2019 Jan 24. Epub 2019 Jan 24.

Department of Neonatology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

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http://dx.doi.org/10.1038/s41372-019-0323-zDOI Listing
January 2019
2.347 Impact Factor

Reducing parental trauma and stress in neonatal intensive care: systematic review and meta-analysis of hospital interventions.

J Perinatol 2019 Jan 18. Epub 2019 Jan 18.

Departments of Pediatrics, Anesthesiology, Psychiatry and Biobehavioral Sciences, University of California-Los Angeles (UCLA), Los Angeles, CA, USA.

Objective: To classify NICU interventions for parental distress and quantify their effectiveness.

Study Design: We systematically reviewed controlled studies published before 2017 measuring NICU parental distress, defined broad intervention categories, and used random-effects meta-analysis to quantify treatment effectiveness.

Results: Among 1643 unique records, 58 eligible trials predominantly studied mothers of preterm infants. Read More

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http://dx.doi.org/10.1038/s41372-018-0310-9DOI Listing
January 2019
1 Read

Neonatologists' preferences regarding guidelines for periviable deliveries: do we really know what we want?

J Perinatol 2019 Jan 18. Epub 2019 Jan 18.

Division of Neonatology, Department of Pediatrics, Evanston Hospital, NorthShore University HealthSystem, Evanston, IL, USA.

Objective: To examine neonatology providers' preferences regarding periviability guidelines.

Study Design: An online cross-sectional survey of American Academy of Pediatrics Section on Neonatal-Perinatal Medicine members.

Results: Most of the 480 respondents desired standardized guidelines for upper (85%) and lower (87%) gestational age limits for offering resuscitation and comfort care. Read More

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http://dx.doi.org/10.1038/s41372-019-0313-1DOI Listing
January 2019

Maternal parity and functional contractility of human myometrium in vitro in the third trimester of pregnancy.

J Perinatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, National University of Ireland Galway, Galway University Hospital, Galway, Ireland.

Objective: It is well established that the duration of the first and second stages of labor are shorter in parous women than in their nulliparous counterparts, a phenomenon not well understood. The aim was to examine the effect of maternal parity on contractile parameters of human myometrium.

Design: Myometrial strips were excised from n = 74 women at cesarean delivery and recordings of contractile activity analyzed and compared across three clinical groups: 1. Read More

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http://dx.doi.org/10.1038/s41372-019-0312-2DOI Listing
January 2019
2 Reads

Elevated midline head positioning of extremely low birth weight infants: effects on cardiopulmonary function and the incidence of periventricular-intraventricular hemorrhage.

Authors:
W Thomas Bass

J Perinatol 2019 Jan 17. Epub 2019 Jan 17.

Eastern Virginia Medical School, Pediatrics, Neonatology. Children's Hospital of The King's Daughters 401 Children's Lane, Norfolk, VA, 23507, USA.

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http://dx.doi.org/10.1038/s41372-018-0307-4DOI Listing
January 2019

Impact of patient handover structure on neonatal perioperative safety.

J Perinatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Pediatric Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.

Objective: To compare the incidence, severity, preventability, and contributing factors of non-routine events-deviations from optimal care based on the clinical situation-associated with team-based, nurse-to-nurse, and mixed handovers in a large cohort of surgical neonates.

Study Design: A prospective observational study and one-time cross-sectional provider survey were conducted at one urban academic children's hospital. 130 non-cardiac surgical cases in 109 neonates who received pre- and post-operative NICU care. Read More

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http://www.nature.com/articles/s41372-018-0305-6
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http://dx.doi.org/10.1038/s41372-018-0305-6DOI Listing
January 2019
6 Reads
2.347 Impact Factor

To transfuse or not transfuse a premature infant: the new complex question.

J Perinatol 2019 Jan 16. Epub 2019 Jan 16.

The Charlotte R. Bloomberg Children's Center/Room 8530, 1800 Orleans Street, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1038/s41372-018-0306-5DOI Listing
January 2019

Racial disparities in intrapartum group B Streptococcus colonization: a higher incidence of conversion in African American women.

J Perinatol 2019 Jan 11. Epub 2019 Jan 11.

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Objective: To compare the incidence of group B Streptococcus (GBS) conversion from a negative antepartum to a positive intrapartum culture among women who self-identify as non-Hispanic black, Hispanic, or non-Hispanic white.

Study Design: This was a prospective cohort study of women with a negative rectovaginal GBS culture obtained within 35 days of enrollment. An intrapartum rectovaginal swab was collected and cultured for GBS. Read More

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http://dx.doi.org/10.1038/s41372-018-0308-3DOI Listing
January 2019

The use of less invasive surfactant administration (LISA) in the United States with review of the literature.

J Perinatol 2019 Jan 11. Epub 2019 Jan 11.

University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: The majority of extremely low gestational age neonates undergo intubation for surfactant therapy. Less invasive surfactant administration (LISA) uses a thin catheter inserted into the trachea to deliver the surfactant. During the procedure, the infant is breathing spontaneously while supported with continuous positive airway pressure. Read More

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http://dx.doi.org/10.1038/s41372-018-0302-9DOI Listing
January 2019

Death or resolution: the "natural history" of pulmonary hypertension in bronchopulmonary dysplasia.

J Perinatol 2019 Jan 7. Epub 2019 Jan 7.

Pediatric Cardiology, Stanford University School of Medicine - Lucile Packard Children's Hospital, Stanford, Stanford, CA, USA.

Objectives: The primary objective was to describe the early "natural history" of pulmonary hypertension (PH) in the premature population. The secondary objective was to describe factors associated with poor outcomes in the premature population with PH at 36 weeks post-menstrual age (PMA).

Study Design: Retrospective chart review of patients followed at our institution from 2000 to 2017 with echocardiographic (ECHO) evidence of PH at 36 weeks PMA, and born ≤ 32 weeks estimated gestational age (GA). Read More

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http://dx.doi.org/10.1038/s41372-018-0303-8DOI Listing
January 2019
2 Reads

Neonatologist salary: factors, equity and gender.

J Perinatol 2019 Jan 7. Epub 2019 Jan 7.

Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.

Objective: Physician compensation has been found to be influenced by gender, academic affiliation, specialty, productivity, and time in practice. This study explores their impact in the field of neonatology to inform institutional strategic planning and decisions by current and future practitioners.

Study Design: A voluntary anonymous survey was distributed to members of the American Academy of Pediatrics Section on Neonatal-Perinatal Medicine with a 15% response rate. Read More

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http://dx.doi.org/10.1038/s41372-018-0304-7DOI Listing
January 2019

Reduced rate of treated retinopathy of prematurity after implementing lower oxygen saturation targets.

J Perinatol 2019 Jan 7. Epub 2019 Jan 7.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Objective: To evaluate an implementation of lower oxygen saturation targets with retinopathy of prematurity (ROP) as primary outcome, in infants at the lowest extreme of prematurity.

Study Design: Retrospective cohort including infants born at 22-25 weeks of gestation in 2005-2015 (n = 325), comparing high (87-93%) and low (85-90%) targets; infants transferred early were excluded from the main analysis to avoid bias.

Results: Overall survival was 76% in high saturation era, and 69% in low saturation era (p = . Read More

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http://dx.doi.org/10.1038/s41372-018-0300-yDOI Listing
January 2019

Risk of preterm and early term birth by maternal drug use.

J Perinatol 2019 Feb 20;39(2):286-294. Epub 2018 Dec 20.

California Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.

Objective: Examine the risk of preterm birth (PTB, < 37 weeks) and early term birth (37-38 weeks) for women with reported drug abuse/dependence.

Study Design: The population was drawn from singleton livebirths in California from 2007 to 2012. Drug abuse/dependence was determined from maternal diagnostic codes (opioid, cocaine, cannabis, amphetamine, other, or polysubstance). Read More

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http://dx.doi.org/10.1038/s41372-018-0299-0DOI Listing
February 2019
2 Reads

Drivers of referrals to a children's hospital neonatal-infant intensive care unit.

J Perinatol 2019 Feb 20;39(2):295-299. Epub 2018 Dec 20.

The Children's Hospital of Philadelphia, Division of Neonatology, 2nd Floor Main 34th Street & Civic Center Blvd, Philadelphia, Pennsylvania, 19104, USA.

Objectives: Evaluate the outreach program of a regional NICU for referral satisfaction, drivers and barriers, preferences for service methods, outreach communication, and education.

Study Design: To point out prevalence assessment of preferences, referral reasons, satisfaction and general feedback by regional neonatologists implemented by electronic survey using either multiple-choice or Likert scale questions. Survey questions were derived via consensus of the outreach program team. Read More

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http://dx.doi.org/10.1038/s41372-018-0297-2DOI Listing
February 2019

The complexity of physicians' understanding and management of prognostic uncertainty in neonatal hypoxic-ischemic encephalopathy.

J Perinatol 2019 Feb;39(2):278-285

Institut de recherches cliniques de Montréal, 110 Pine Avenue West, Montreal, QC, H2W1R7, Canada.

Objective: Prognosis of Hypoxic-Ischemic Encephalopathy (HIE) remains challenging and uncertain. This paper investigates how physicians understand and address the ethical challenges of prognostic uncertainty in the case of neonatal HIE, contextualized within the social science literature.

Study Design: Semi-structured interviews were conducted with 12 Canadian neurologists and neonatologists, addressing their perspectives and clinical experiences concerning neonatal HIE prognostication. Read More

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http://dx.doi.org/10.1038/s41372-018-0296-3DOI Listing
February 2019

Understanding health disparities.

J Perinatol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Based upon our recent insights into the determinants of preterm birth, which is the leading cause of death in children under five years of age worldwide, we describe potential analytic frameworks that provides both a common understanding and, ultimately the basis for effective, ameliorative action. Our research on preterm birth serves as an example that the framing of any human health condition is a result of complex interactions between the genome and the exposome. New discoveries of the basic biology of pregnancy, such as the complex immunological and signaling processes that dictate the health and length of gestation, have revealed a complexity in the interactions (current and ancestral) between genetic and environmental forces. Read More

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http://www.nature.com/articles/s41372-018-0298-1
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http://dx.doi.org/10.1038/s41372-018-0298-1DOI Listing
December 2018
4 Reads

A population-based study of cystic white matter injury on ultrasound in very preterm infants born over two decades in Nova Scotia, Canada.

J Perinatol 2019 Feb 14;39(2):269-277. Epub 2018 Dec 14.

Department of Radiology, Dalhousie University and the IWK Health Centre, Halifax, NS, Canada.

Objective: To identify the temporal trends, risk factors and outcomes of cystic white matter injury (WMI) detected by ultrasound in a population-based cohort of very preterm infants (VPI) with a minimal risk of selection bias.

Study Design: All live-born VPIs between 22 and < 31 weeks gestational age born in Nova Scotia, Canada from 1993 to 2013.

Results: Cystic WMI was identified in 87 (7%) out of 1184 eligible infants. Read More

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http://dx.doi.org/10.1038/s41372-018-0294-5DOI Listing
February 2019

Comparison of macronutrient content in human milk measured by mid-infrared human milk analyzer and reference methods.

J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Nestlé Research, Vers-chez-les Blanc, P.O. Box 44, 1000, Lausanne 26, Switzerland.

Objective: The study aims at evaluating mid-infrared human milk analyzer (HMA) accuracy and precision, in human milk (HM).

Study Design: Röse-Gottlieb, high-performance anion exchange chromatography-pulsed amperometric detection (HPAEC-PAD), Kjeldahl and amino acid analysis (AA) were selected as references for total fat, lactose and total protein determination.

Results: No significant difference was observed in lactose content between HMA and HPAEC-PAD. Read More

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http://dx.doi.org/10.1038/s41372-018-0291-8DOI Listing
December 2018
1 Read

"STEP", an early developmental screening tool that predicts one-year outcomes.

Authors:
T Michael O'Shea

J Perinatol 2019 Feb 13;39(2):153-155. Epub 2018 Dec 13.

University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41372-018-0293-6DOI Listing
February 2019

Preconception insurance and initiation of prenatal care.

J Perinatol 2019 Feb 13;39(2):300-306. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.

Objective: The primary objective was to determine the association between preconception insurance and initiation of prenatal care.

Study Design: This retrospective cohort uses data from the Pregnancy Risk Assessment Monitoring System (2009-2013). Self-reported preconception insurance status was the primary exposure. Read More

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http://www.nature.com/articles/s41372-018-0292-7
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http://dx.doi.org/10.1038/s41372-018-0292-7DOI Listing
February 2019
7 Reads

While waiting for a vaccine: opportunities for optimization of neonatal group B streptococcal (GBS) disease prevention in Israel.

J Perinatol 2019 Feb 11;39(2):331-338. Epub 2018 Dec 11.

Stanford University School of Medicine, Division of Neonatal & Developmental Medicine, Palo Alto, CA, 94304, USA.

Objective: To quantify effects of different strategies for decreasing neonatal early onset GBS sepsis (EOGBS) in Israel.

Study Design: A risk allocation model for EOGBS among infants ≥ 35w was adapted to Israeli data. Effects of strategies for antepartum (APS) and intrapartum (IPS) screening, and intrapartum (IAP) and/or postpartum antibiotic prophylaxis (PAP) were calculated. Read More

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http://dx.doi.org/10.1038/s41372-018-0289-2DOI Listing
February 2019
3 Reads

Delayed cord clamping in preterm infants: is it time to become standard practice?

J Perinatol 2018 Dec 11. Epub 2018 Dec 11.

Texas Children's Newborn Center, Texas Children's Hospital, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41372-018-0286-5DOI Listing
December 2018