5,208 results match your criteria Journal of Perinatology[Journal]


Maternal smoking and neurodevelopmental outcomes in infants <29 weeks gestation: a multicenter cohort study.

J Perinatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pediatrics, University of Calgary, Calgary, AB, Canada.

Objective: To compare neurodevelopmental outcomes of preterm infants at 18-21 months corrected age (CA) whose mothers smoked during pregnancy to those whose mothers did not smoke.

Study Design: Preterm infants born at <29 weeks of gestation and evaluated at 18-21 months CA were included. Primary outcome was a composite outcome of death or neurodevelopmental impairment (NDI). Read More

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http://www.nature.com/articles/s41372-019-0356-3
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http://dx.doi.org/10.1038/s41372-019-0356-3DOI Listing
April 2019
6 Reads

Maternal breast milk feeding and length of treatment in infants with neonatal abstinence syndrome.

J Perinatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Neonatology, Thomas Jefferson University Hospital/Nemours, Philadelphia, PA, USA.

Objective: The objective of this study is to assess whether infants with neonatal abstinence syndrome (NAS), who receive maternal breast milk (BM), have shorter pharmacological treatment durations and lengths of stay compared with formula-fed infants.

Study Design: Retrospective data analysis from Optum Neonatal Database for infants born between 1 January 2010 and 21 November 2016, who received treatment for NAS. Clinical characteristics and outcomes were compared between infants who received any amount of BM and those exclusively formula-fed. Read More

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http://dx.doi.org/10.1038/s41372-019-0374-1DOI Listing

Postnatal intervention for the treatment of FNAIT: a systematic review.

J Perinatol 2019 Apr 10. Epub 2019 Apr 10.

Division of Haematology/Oncology, CHU Sainte-Justine, University of Montreal, Montreal, Canada.

Objective: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is associated with life-threatening bleeding. This systematic review of postnatal management of FNAIT examined transfusion of human platelet antigen (HPA) selected or unselected platelets, and/or IVIg on platelet increments, hemorrhage and mortality.

Study Design: MEDLINE, EMBASE and Cochrane searches were conducted until 11 May 2018. Read More

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http://dx.doi.org/10.1038/s41372-019-0360-7DOI Listing
April 2019
1 Read

Chlorhexidine baths in preterm infants - are we there yet?

J Perinatol 2019 Apr 10. Epub 2019 Apr 10.

Division of Neonatology, Department of Pediatrics, NYU Winthrop Hospital, Mineola, NY, USA.

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http://www.nature.com/articles/s41372-019-0378-x
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http://dx.doi.org/10.1038/s41372-019-0378-xDOI Listing
April 2019
2 Reads

Maternal anemia and pregnancy outcomes: a population-based study.

J Perinatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.

Objective: This study aims to describe adverse maternal and neonatal outcomes in women diagnosed with anemia in pregnancy.

Study Design: This was a retrospective cohort study of California live births from 2007-2012, linked to maternal and infant hospital discharge records. Relative risks of adverse maternal and neonatal outcomes were calculated for women with and without anemia. Read More

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http://dx.doi.org/10.1038/s41372-019-0375-0DOI Listing
April 2019
1 Read

Early transpyloric vs gastric feeding in preterm infants: a retrospective cohort study.

J Perinatol 2019 Apr 9. Epub 2019 Apr 9.

Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.

Background: Neonatal transpyloric feeding (TPF) has not been rigorously studied since the 1980s. Our objective was to evaluate early TPF, defined as TPF initiated within the first week after birth, among preterm infants in the setting of modern neonatal practice.

Study Design: A retrospective cohort study was conducted between 2013 and 2017 for all extremely low birth weight (ELBW) infants born in a tertiary neonatal intensive care unit where early TPF is a common practice. Read More

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http://dx.doi.org/10.1038/s41372-019-0372-3DOI Listing

Early psychosocial development of small for gestational age and intrauterine growth-restricted children: a systematic review.

J Perinatol 2019 Apr 9. Epub 2019 Apr 9.

School of Nursing and Midwifery, Queen's University Belfast, Belfast, Northern Ireland.

Objective: To examine evidence regarding psychosocial development from one month to four years of age in small for gestational age and intrauterine growth-restricted children.

Study Design: Studies were included if participants met criteria for small for gestational age or intrauterine growth restriction, follow-up was from age 1 month to 4 years, methods were described, and appropriate comparison groups were included. Methodological quality of included studies was assessed using quality-appraisal guidelines. Read More

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http://www.nature.com/articles/s41372-019-0369-y
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http://dx.doi.org/10.1038/s41372-019-0369-yDOI Listing
April 2019
4 Reads

Neurobehavior of preterm infants from 32 to 48 weeks post-menstrual age.

J Perinatol 2019 Apr 8. Epub 2019 Apr 8.

Division of Neonatal Medicine, Department of Pediatrics, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil.

Aim: Evaluate prospectively the neurobehavior of preterm infants (PT).

Study Design: Cohort of PT (gestational age(GA) <32weeks), evaluated biweekly from 32 to 48 weeks post-menstrual age (PMA) by NICU Network Neurobehavioral Scale (NNNS). Scores were compared by repeated Measures ANOVA. Read More

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http://dx.doi.org/10.1038/s41372-019-0376-zDOI Listing

Correction: Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy.

J Perinatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

A correction to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41372-019-0371-4DOI Listing
April 2019
1 Read

Hospital contribution to variation in rates of vaginal birth after cesarean.

J Perinatol 2019 Apr 5. Epub 2019 Apr 5.

University of Michigan, Department of Obstetrics and Gynecology, Ann Arbor, MI, USA.

Objective: To determine the influence of delivery hospital on the rate of vaginal birth after cesarean (VBAC).

Study Design: This retrospective cohort study used claims data from Blue Cross and Blue Shield of Michigan. Women with a prior cesarean and a singleton livebirth between 2012 and 2016 were included. Read More

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http://dx.doi.org/10.1038/s41372-019-0373-2DOI Listing
April 2019
4 Reads

Umbilical cord milking in preterm infants: time to act.

J Perinatol 2019 Apr 5. Epub 2019 Apr 5.

Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India.

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http://dx.doi.org/10.1038/s41372-019-0377-yDOI Listing
April 2019
1 Read
2.347 Impact Factor

Serum podocalyxin at 11-13 weeks of gestation in the prediction of small for gestational age neonates.

J Perinatol 2019 Apr 5. Epub 2019 Apr 5.

Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Melbourne, VIC, Australia.

Objective: To investigate a potential new marker for the prediction of small for gestational age (SGA) infants.

Study Design: Nested case-control study involving 280 uncomplicated pregnancies and 70 cases of SGA without pre-eclampsia. Serum podocalyxin was measured at 11-13 weeks of gestation and results were expressed in multiples of the median (MoM). Read More

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http://dx.doi.org/10.1038/s41372-019-0370-5DOI Listing
April 2019
1 Read

Evaluating shared decision-making in periviable counseling using objective structured clinical examinations.

J Perinatol 2019 Apr 3. Epub 2019 Apr 3.

Assistant Dean for Medical Education and Academic Affairs & Associate Professor of Integrated Medical Science, Integrated Medical Science Department, Charles E. Schmidt College of Medicine at Florida Atlantic University, Boca Raton, FL, USA.

Objective: To develop and test an Objective Structured Clinical Examination to evaluate the use of shared decision-making (SDM) in periviable counseling among fourth-year OB/GYN residents.

Methods: Residents counseled a standardized patient presenting with preterm premature rupture of membranes at 23 weeks' gestation. Braddock's 9-item measure of SDM was adapted to a 10-item scoring rubric; rating each: 0 (absent), 1 (partial), or 2 (complete). Read More

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http://dx.doi.org/10.1038/s41372-019-0366-1DOI Listing
April 2019
1 Read

Cefazolin pharmacokinetics in premature infants.

J Perinatol 2019 Apr 3. Epub 2019 Apr 3.

Duke Clinical Research Institute, Durham, NC, USA.

Objective: Pharmacokinetic (PK) data to guide cefazolin dosing in premature infants are virtually non-existent. Therefore, we aimed to characterize cefazolin PK in infants aged ≤32 weeks of gestation at birth.

Study Design: We conducted a prospective, open-label PK and safety study of cefazolin in infants ≤32 weeks gestation from a University Medical Center. Read More

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http://dx.doi.org/10.1038/s41372-019-0368-zDOI Listing

Effect of behavioral change intervention around new-born care practices among most marginalized women in self-help groups in rural India: analyses of three cross-sectional surveys between 2013 and 2016.

J Perinatol 2019 Apr 2. Epub 2019 Apr 2.

Population Council, New Delhi, India.

Objective: To assess the effects of new-born care intervention through self-help groups in improving new-born healthcare practices in rural India.

Methods: A quasi-experimental design was used to evaluate behavioral change intervention integrated in >25,000 microfinance-based self-help groups in rural Bihar. Three rounds of cross-sectional surveys were conducted to understand the impact of intervention on new-born healthcare practices by talking to women who delivered a baby in the last 6 months. Read More

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http://dx.doi.org/10.1038/s41372-019-0358-1DOI Listing

Premedication with neuromuscular blockade and sedation during neonatal intubation is associated with fewer adverse events.

J Perinatol 2019 Apr 2. Epub 2019 Apr 2.

Center for simulation, Advanced Education and Innovation, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objective: To determine the impact of premedication for tracheal intubation (TI) on adverse TI associated events, severe oxygen desaturations, and first attempt success STUDY DESIGN: Retrospective cohort study in neonatal intensive care units (NICU) participating in the National Emergency Airway Registry for Neonates from 10/2014 to 6/2017. Premedication for TI was categorized as sedation with neuromuscular blockade, sedation only, or no medication.

Results: 2260 TIs were reported from 11 NICUs. Read More

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http://dx.doi.org/10.1038/s41372-019-0367-0DOI Listing
April 2019
2.347 Impact Factor

Large-for-gestational-age fetuses have an increased risk for spontaneous preterm birth.

J Perinatol 2019 Apr 2. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objective: Our aim was to investigate the association between large-for-gestational-age and the risk of spontaneous preterm birth.

Study Design: We studied nulliparous women with a singleton gestation using data from the Dutch perinatal registry from 1999 to 2010. Neonates were categorized according to the Hadlock fetal weight standard, into 10th to 90th percentile, 90th to 97th percentile, or above 97th percentile. Read More

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http://dx.doi.org/10.1038/s41372-019-0361-6DOI Listing
April 2019
1 Read

Dysnatremia in extremely low birth weight infants is associated with multiple adverse outcomes.

J Perinatol 2019 Apr 1. Epub 2019 Apr 1.

Pediatrix Medical Group, San Antonio, TX, USA.

Objective: The objective of this study is to discern patterns of serum sodium in a broad cohort of extremely low birth weight (ELBW) infants and associate those patterns with hospital outcomes.

Study Design: Retrospective cohort study of ELBW infants from 323 neonatal intensive care units (NICUs) discharged from 2004 to 2014. We included patients who survived at least 7 days and had daily sodium levels available, and categorized infants by their minimum and maximum sodium levels. Read More

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http://dx.doi.org/10.1038/s41372-019-0359-0DOI Listing
April 2019
1 Read

Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity.

J Perinatol 2019 Apr 1. Epub 2019 Apr 1.

Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

Objective: To evaluate the relationship between prenatal and postnatal inflammation-related risk factors and severe retinopathy of prematurity (ROP).

Study Design: The study included infants born <30 weeks in California from 2007 to 2011. Multivariable log-binomial regression was used to assess the association between prenatal and postnatal inflammation-related exposures and severe ROP, defined as stage 3-5 or surgery for ROP. Read More

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http://dx.doi.org/10.1038/s41372-019-0357-2DOI Listing
April 2019
1 Read

Procalcitonin versus C-reactive protein: review of kinetics and performance for diagnosis of neonatal sepsis.

J Perinatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Pediatrics, Mildred Stahlman Divison of Neonatology, Vanderbilt University Medical Center, Monroe Carrol Jr. Children's Hospital, Nashville, TN, USA.

Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers, but their diagnostic advantage for neonatal early-onset (EOS) or late-onset (LOS) sepsis is controversial. In a comprehensive literature review we found significant heterogeneity between studies in sample timing, cut-off values, consideration of blood culture results for sepsis classification, and definition of EOS versus LOS. We identified 39 studies directly comparing PCT with CRP, but only four in very low birth weight (VLBW) neonates. Read More

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http://dx.doi.org/10.1038/s41372-019-0363-4DOI Listing

A multi-center evaluation of a device for measurement of bilirubin binding capacity in neonates: the effects of gestational age, Intralipid exposure and illness severity.

J Perinatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

Objective: Measure daily bilirubin-binding capacity (BBC) variation using an automated, not as-yet FDA approved, Point-of-Care hematofluorometer. Measure the effects of prematurity, clinical instability and exposure to Intralipid on BBC.

Subjects: Convenience sample of 109 infants from well-baby and intensive care nurseries. Read More

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http://dx.doi.org/10.1038/s41372-019-0365-2DOI Listing
March 2019
7 Reads

Antecedents of epilepsy and seizures among children born at extremely low gestational age.

J Perinatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Pediatrics, Division of Pediatric Neurology, Boston Medical Center and Boston University School of Medicine, Boston, MA, USA.

Objective: To identify specific risk factors for epilepsy for individuals born extremely preterm.

Study Design: In a prospective cohort study, at 10-year follow-up, children were classified as having epilepsy or seizures not associated with epilepsy. We evaluated for association of perinatal factors using time-oriented, multinomial logistic regression models. Read More

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http://dx.doi.org/10.1038/s41372-019-0355-4DOI Listing

The effect of gestational diabetes mellitus on human milk macronutrients content.

J Perinatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Pediatrics, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Objective: To test the null hypothesis that human milk (HM) macronutrients (fat, lactose, protein) and caloric content in women with gestational diabetes mellitus (GDM) is similar to that of women without GDM.

Study Design: Sixty-two lactating mothers (31 GDM, 31 no-GDM) were studied after confirmation by 100-g oral glucose tolerance test. Each mother contributed three manually expressed HM samples (within 72 h after labor (colostrum), after 7 days (transitional) and at 14 days (mature)). Read More

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http://dx.doi.org/10.1038/s41372-019-0362-5DOI Listing
March 2019
2 Reads

Diagnosis of congenital/perinatal infections by neonatologists: a national survey.

J Perinatol 2019 May 26;39(5):690-696. Epub 2019 Mar 26.

Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.

Objective: To describe the clinical approach used by neonatologists for diagnosis of congenital/perinatal infections (CPI); no such data currently exist.

Study Design: A national survey regarding the diagnosis of toxoplasma, syphilis, rubella, cytomegalovirus, and herpes simplex virus (HSV) infection in neonates.

Result: We received 553 (11%) responses. Read More

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http://dx.doi.org/10.1038/s41372-019-0364-3DOI Listing
May 2019
1 Read

Association between time of day and performance, indications, and outcomes of obstetric interventions among nulliparous women delivering at term.

J Perinatol 2019 Mar 25. Epub 2019 Mar 25.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Objective: The objective of this study is to determine whether there is an association between delivery time and obstetric interventions, as well as maternal and perinatal outcomes.

Study Design: Retrospective cohort study of nulliparous women delivering singleton, vertex, live births at ≥37 weeks gestation at a single center from 2014 to 2015. Nighttime deliveries were designated as those occurring between 18:00 and 05:59 h. Read More

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http://dx.doi.org/10.1038/s41372-019-0353-6DOI Listing

Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014.

J Perinatol 2019 May 25;39(5):697-707. Epub 2019 Mar 25.

Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Objective: To examine the temporal trends in the incidence and outcomes of neonatal herpes simplex infections (NHSV) in the United States.

Study Design: We conducted a retrospective study using the National Inpatient Sample (NIS). Neonates ≤28 days old with ICD-9 codes for NHSV (054. Read More

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http://dx.doi.org/10.1038/s41372-019-0352-7DOI Listing

Cardiac mechanics in infants with Down syndrome in the early neonatal period.

J Perinatol 2019 May 25;39(5):626-633. Epub 2019 Mar 25.

Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.

Objective: The objective of this study is to test whether myocardial performance is impaired over the first week of age in infants with Down syndrome (DS) without congenital heart disease (CHD).

Study Design: A prospective cohort study of 20 infants with DS without CHD and 17 healthy term infants comparing echocardiographic measures of left (LV) and right (RV) ventricular function and pulmonary hypertension (PH) on days 1, 2, and 5-7.

Results: Indices of PH were higher in the DS group over the study period. Read More

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http://www.nature.com/articles/s41372-019-0354-5
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http://dx.doi.org/10.1038/s41372-019-0354-5DOI Listing
May 2019
5 Reads

Adrenal insufficiency in neonates undergoing cardiopulmonary bypass and postoperative hypothalamic-pituitary-adrenal function after prophylactic glucocorticoids.

J Perinatol 2019 May 12;39(5):640-647. Epub 2019 Mar 12.

Division of Critical Care Medicine, Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TX, USA.

Objectives: Determine incidence of preoperative adrenal insufficiency in neonates >35 weeks gestation with congenital heart disease undergoing cardiothoracic surgery with bypass and effects of prophylactic methylprednisolone on postoperative hypothalamic-pituitary-adrenal function and hemodynamic stability.

Design: Prospective observational study in 36 neonates with preoperative adrenocorticotrophic hormone stimulation tests and serial total cortisol and adrenocorticotrophic hormone measurements before and after surgery. Data analyses: analysis of variance and regression. Read More

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http://dx.doi.org/10.1038/s41372-019-0344-7DOI Listing
May 2019
3 Reads

Neonatal postgraduate training program for physician assistants: meeting a need in neonatal care.

J Perinatol 2019 May 11;39(5):746-753. Epub 2019 Mar 11.

Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, KY, USA.

There is a growing need for advanced practice providers in the NICU. Physician assistants (PAs) with postgraduate training in neonatology can help meet these demands. The premise of training PAs to work in the NICU is being adopted by multiple centers nationwide. Read More

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http://www.nature.com/articles/s41372-019-0350-9
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http://dx.doi.org/10.1038/s41372-019-0350-9DOI Listing
May 2019
5 Reads

Cesarean for non-reassuring fetal status: effect of obesity on decision to delivery interval.

J Perinatol 2019 Mar 11. Epub 2019 Mar 11.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, United States.

Objective: To evaluate the impact of obesity on the decision to delivery interval.

Study Design: We compared the interval to delivery in normal, obese (BMI 30-40 kg/m), and morbidly obese (BMI over 40 kg/m) women. In a planned sub-analysis, we evaluated those who underwent emergency cesarean. Read More

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http://dx.doi.org/10.1038/s41372-019-0351-8DOI Listing

Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy.

J Perinatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Therapeutic hypothermia (TH) has become the standard of care treatment to improve morbidity and mortality in infants with hypoxic-ischemic encephalopathy (HIE). Although TH has clearly proven to be beneficial, recent studies suggest optimization of respiratory management as an approach to prevent further damage and improve neurodevelopmental outcome. The ventilatory management of asphyxiated neonates presents a challenge because both the hypoxic insult and TH have an impact on respiratory functions. Read More

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http://dx.doi.org/10.1038/s41372-019-0349-2DOI Listing
March 2019
2 Reads

Relationship between vitamin D status and the vaginal microbiome during pregnancy.

J Perinatol 2019 Mar 11. Epub 2019 Mar 11.

Division of Neonatology, Shawn Jenkins Children's Hospital, Medical University of South Carolina Children's Hospital, Charleston, SC, USA.

Objective: Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. Read More

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http://dx.doi.org/10.1038/s41372-019-0343-8DOI Listing
March 2019
2 Reads

Association between maternal serious mental illness and adverse birth outcomes.

J Perinatol 2019 May 8;39(5):737-745. Epub 2019 Mar 8.

Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA, USA.

Objective: To evaluate the contribution of serious mental illness (SMI) and specific risk factors (comorbidities and substance use) to the risk of adverse birth outcomes.

Study Design: This cross-sectional study uses maternal delivery records in the Healthcare Cost and Utilization Project Nationwide/National Inpatient Sample (HCUP-NIS) to estimate risk factor prevalence and relative risk of adverse birth outcomes (e.g. Read More

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http://www.nature.com/articles/s41372-019-0346-5
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http://dx.doi.org/10.1038/s41372-019-0346-5DOI Listing
May 2019
4 Reads

Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320).

J Perinatol 2019 May 8;39(5):599-607. Epub 2019 Mar 8.

Department of Pediatrics, University of California, San Francisco, CA, USA.

Objective: To evaluate the effectiveness of drugs used to constrict patent ductus arteriosus (PDA) in newborns < 28 weeks.

Methods: We performed a secondary analysis of the multi-center PDA-TOLERATE trial (NCT01958320). Infants with moderate-to-large PDAs were randomized 1:1 at 8. Read More

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http://dx.doi.org/10.1038/s41372-019-0347-4DOI Listing
May 2019
1 Read
2.347 Impact Factor

In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation.

J Perinatol 2019 May 6;39(5):661-665. Epub 2019 Mar 6.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan/Wayne State University, Detroit, MI, USA.

Objective: To determine in-hospital outcomes of neonates with hypoxic ischemic encephalopathy (HIE) requiring extracorporeal membrane oxygenation (ECMO).

Study Design: Single-center retrospective study from 2005 to 2016 of neonates ≥35 weeks gestation with moderate/severe HIE, requiring ECMO for persistent pulmonary hypertension of newborn (PPHN).

Results: Our cohort (n = 20) received therapeutic hypothermia for moderate (n = 12), severe (n = 5), or undocumented severity (n = 3) of HIE. Read More

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http://dx.doi.org/10.1038/s41372-019-0345-6DOI Listing
May 2019
1 Read

Correction: Association of chorioamnionitis and its duration with neonatal morbidity and mortality.

J Perinatol 2019 May;39(5):761

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.

This correction is to acknowledge that funding was supported by the Intramural Research Program of the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The Consortium on Safe Labor was funded by the Intramural Research Program of the NICHD, through Contract No. HHSN267200603425C. Read More

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http://dx.doi.org/10.1038/s41372-019-0341-xDOI Listing

Left ventricular cardiac output is a reliable predictor of extracorporeal life support in neonates with congenital diaphragmatic hernia.

J Perinatol 2019 May 5;39(5):648-653. Epub 2019 Mar 5.

CHOC Children's Hospital, Division of Neonatology, Orange, CA, USA.

Objective: Congenital diaphragmatic hernia (CDH) is a treatable condition but despite optimal management, some patients require extracorporeal life support (ECLS). This study evaluates the association of left ventricular (LV) cardiac output and the need for ECLS.

Study Design: Single center, retrospective chart review from 1/1/2012 through 7/1/2018. Read More

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http://dx.doi.org/10.1038/s41372-019-0348-3DOI Listing
May 2019
2 Reads

Fetal heart rate, heart rate variability, and heart rate/movement coupling in the Safe Passage Study.

J Perinatol 2019 May 4;39(5):608-618. Epub 2019 Mar 4.

Department of Psychiatry, Columbia University Medical Center, New York, NY, 10032, USA.

Objective: To determine normative values for heart rate patterns in healthy fetuses.

Methods: This research is from the Safe Passage Study conducted by the Prenatal Alcohol and SIDS and Stillbirth (PASS) Network. A standardized protocol assessed fetal heart rate (FHR), heart rate variability (HRV), and movement from 1655 fetuses at three-time points during gestation (20-24 weeks, 28-32 weeks, 34-38 weeks gestation). Read More

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http://www.nature.com/articles/s41372-019-0342-9
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http://dx.doi.org/10.1038/s41372-019-0342-9DOI Listing
May 2019
5 Reads

State of the journal: 2019.

Authors:
Edward E Lawson

J Perinatol 2019 Mar 22;39(3):345-350. Epub 2019 Feb 22.

Johns Hopkins School of Medicine, 1800 Orleans Street, Mailstop 8-South, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1038/s41372-018-0309-2DOI Listing

Who's counting? Assessing the effects of a simulation-based training intervention on the accuracy of neonatal heart rate auscultation.

J Perinatol 2019 May 15;39(5):634-639. Epub 2019 Feb 15.

Department of Pediatrics, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.

Objective: To determine if simulation-based medical education could improve pediatric residents' ability to accurately assess neonatal heart rate via auscultation.

Study Design: Primary outcomes included heart rate accuracy and Neonatal Resuscitation Program (NRP) group accuracy, defined as whether a heart rate estimation fell in the appropriate NRP algorithm group. Pediatric residents completed a pre-assessment and then participated in a simulation training intervention on high-fidelity manikins. Read More

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http://dx.doi.org/10.1038/s41372-019-0339-4DOI Listing
May 2019
1 Read

Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury.

J Perinatol 2019 May 15;39(5):730-736. Epub 2019 Feb 15.

Medical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO removal while potentially reducing the risk of ventilator-induced lung injury.

Objective: To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.

Study Design: Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO). Read More

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http://dx.doi.org/10.1038/s41372-019-0338-5DOI Listing
May 2019
1 Read

Health literacy of parents of very preterm infants at NICU admission and discharge: a prospective cohort study.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objective: To determine the prevalence of limited health literacy in parents of infants born ≤32 and 0/7 weeks and if health literacy changes during hospitalization.

Study Design: Multi-site, prospective cohort study measuring health literacy using the Parent Health Literacy Activities Test, which estimates caregivers' ability to complete tasks such as reading prescription labels and preparing bottles. Data were analyzed using parametric and nonparametric comparison tests and multivariable regression to control for confounders. Read More

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http://dx.doi.org/10.1038/s41372-019-0340-yDOI Listing
February 2019

The Relationship between blood pressure parameters and left ventricular output in neonates.

J Perinatol 2019 May 15;39(5):619-625. Epub 2019 Feb 15.

Department of Paediatrics, University of Toronto, Toronto, ON, Canada.

Objective: To evaluate the relationship between systolic (SBP), diastolic (DBP), mean (MBP) blood pressures and pulse pressure (PP), and left ventricular output (LVO), a surrogate of systemic blood flow.

Study Design: This retrospective study included neonates who underwent targeted neonatal echocardiography (TNE) in 3-tertiary NICUs over 2 years. Associations between LVO and BP components were investigated. Read More

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http://www.nature.com/articles/s41372-019-0337-6
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http://dx.doi.org/10.1038/s41372-019-0337-6DOI Listing
May 2019
8 Reads

Is early caffeine therapy safe and effective for ventilated preterm infants?

J Perinatol 2019 May 15;39(5):754-757. Epub 2019 Feb 15.

Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/s41372-019-0336-7DOI Listing
May 2019
2.347 Impact Factor

Comparison of early postnatal prediction models for survival in congenital diaphragmatic hernia.

J Perinatol 2019 May 15;39(5):654-660. Epub 2019 Feb 15.

Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Objective: To compare the PF-PCO equation-partial pressure of arterial oxygen (PaO)/fraction of inspired oxygen (FiO) minus partial pressure of carbon dioxide (PCO)-to three other tools for postnatal prediction of survival in infants with congenital diaphragmatic hernia (CDH).

Study Design: A retrospective analysis of 203 infants with CDH from 1 January 2003 to 30 June 2018. Area under the curve (AUC) analysis was performed for survival and secondary outcomes of survival without extracorporeal membrane oxygenation support (ECMO) and death despite ECMO. Read More

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http://www.nature.com/articles/s41372-019-0335-8
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http://dx.doi.org/10.1038/s41372-019-0335-8DOI Listing
May 2019
10 Reads

Placental findings among newborns with hypoxic ischemic encephalopathy.

J Perinatol 2019 Apr 15;39(4):563-570. Epub 2019 Feb 15.

Department of Pediatrics, Women & Infants Hospital of Rhode Island, Providence, RI, USA.

Objective: To determine if pre-specified placental abnormalities among newborns with hypoxic-ischemic encephalopathy (HIE) differ compared to newborns admitted to a NICU without encephalopathy.

Study Design: Retrospective case-control study of newborns with HIE (2006-2014) and controls matched for birth year, gestational age, weight, and gender. One pathologist reviewed archived placental sections using pre-specified criteria. Read More

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http://dx.doi.org/10.1038/s41372-019-0334-9DOI Listing
April 2019
1 Read

Differential effects of the retinopathy of prematurity exam on the physiology of premature infants.

J Perinatol 2019 May 12;39(5):708-716. Epub 2019 Feb 12.

Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.

Objective: To compare the differential effects of the retinopathy of prematurity (ROP) examination on the physiology of premature infants with and without oxygen support.

Study Design: We collected data from 42 premature infants (room air = 19, oxygen support = 23) and compared physiological metrics including heart rate (HR), systemic peripheral saturation (SpO), mesenteric tissue oxygen saturation (StO) and clinical events (oxygen desaturation episodes, bradycardia events, and gastric residuals).

Results: We found significant differences between groups in HR during and briefly after the exam, and in mesenteric StO during eye drop administration, eye exam, and up to 8 min after the exam. Read More

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http://dx.doi.org/10.1038/s41372-019-0331-zDOI Listing
May 2019
4 Reads

Tidal volume transmission during non-synchronized nasal intermittent positive pressure ventilation via RAM cannula.

J Perinatol 2019 May 12;39(5):723-729. Epub 2019 Feb 12.

University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Nasal intermittent positive pressure ventilation (NIPPV) is a widely used mode of support in neonates, during which ventilator inflations may or may not coincide with spontaneous breathing.

Objective: We tested the hypothesis that inflations delivered with NIPPV via RAM cannula and not accompanied by patient effort produce minimal tidal volume as measured by respiratory inductance plethysmography.

Design/methods: Fourteen subjects were monitored while receiving NIPPV. Read More

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http://dx.doi.org/10.1038/s41372-019-0333-xDOI Listing
May 2019
6 Reads

Outcomes of preterm infants conceived with in vitro fertilization.

J Perinatol 2019 May 5;39(5):717-722. Epub 2019 Feb 5.

The Center for Research, Education, Quality and Safety, MEDNAX National Medical Group, Sunrise, FL, USA.

Objectives: To determine if there is increased risk of prematurity-related complications for in vitro fertilization (IVF)-conceived preterm infants compared to matched controls.

Study Design: Cohort study of 23-34 weeks' preterm infants from 329 US NICUs discharged from 2009 to 2016. Each IVF patient was matched to three controls. Read More

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http://www.nature.com/articles/s41372-019-0332-y
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http://dx.doi.org/10.1038/s41372-019-0332-yDOI Listing
May 2019
17 Reads

Feeding during transfusion and the risk of necrotizing enterocolitis in preterm infants.

J Perinatol 2019 Apr 5;39(4):540-546. Epub 2019 Feb 5.

Carman and Ann Department of Pediatrics, Department of Pediatrics, Hutzel Women's Hospital, 3980 John R Rd, Detroit, MI, 48201, USA.

Objective: To evaluate the effect of withholding feeds during transfusion on transfusion associated acute gut injury (TRAGI).

Study Design: Data were collected on 125 preterm infants before and after the practice of withholding feeds for 12-24 h during transfusion was instituted. Logistic regression was used to examine effects of withholding feeds on TRAGI rates. Read More

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http://dx.doi.org/10.1038/s41372-019-0328-7DOI Listing