3,657 results match your criteria Journal of Perinatal Medicine[Journal]


Usefulness of transcutaneous bilirubin assessment measured in non-photo-exposed skin to guide the length of phototherapy: an observational study.

J Perinat Med 2019 Apr 18. Epub 2019 Apr 18.

Neonatal Unit, Paediatric Service, Hospital Universitario de Getafe, Carretera Madrid - Toledo, Km 12,500, 28905 Getafe, Madrid, Spain.

Background Transcutaneous bilirubinometers are a non-invasive tool to estimate serum bilirubin. However, once on phototherapy (PHT) and after PHT, its usefulness is precluded. The objective of this study was to prove the hypothesis that transcutaneous bilirubin (TcB) assessment in a covered skin area during PHT could be used to guide the duration of PHT in term and moderate-late preterm infants with non-isoimmune hyperbilirubinemia. Read More

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http://dx.doi.org/10.1515/jpm-2018-0429DOI Listing

Perinatal outcome in gestational diabetes according to different diagnostic criteria.

J Perinat Med 2019 Apr 15. Epub 2019 Apr 15.

Helen Schneider Hospital for Women, Rabin Medical Center, 4941492 Petach-Tikva, Israel.

Objectives To evaluate whether gestational diabetes mellitus (GDM) diagnosed by different criteria impacts perinatal outcome. Methods This was a retrospective study of deliveries with a diagnosis of GDM (2014-2016). Perinatal outcomes were compared between patients with: (1) GDM diagnosed according to a single abnormal value on the 100-g oral glucose tolerance test (OGTT); (2) two or more abnormal OGTT values; and (3) a 50-g glucose challenge test (GCT) value ≥200 mg/dL. Read More

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http://www.degruyter.com/view/j/jpme.ahead-of-print/jpm-2019
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http://dx.doi.org/10.1515/jpm-2019-0013DOI Listing
April 2019
2 Reads

Tinker, tailor, infection, inflammation.

J Perinat Med 2019 Apr;47(3):259-261

Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL, USA.

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http://dx.doi.org/10.1515/jpm-2019-0082DOI Listing

Expression of genes involved in inflammation and growth - does sampling site in human full-term placenta matter?

J Perinat Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatrics, School of Medical Sciences, Örebro University, Örebro, Sweden.

Objective To investigate the placental gene expression of substances in the inflammatory cascade and growth factors at nine different well-defined sampling sites in full-term placentas from 12 normal weight healthy non-smoking women with an uncomplicated singleton pregnancy. Methods All placentas (six girls and six boys) were delivered vaginally. Quantitative real-time polymerase chain reaction was used to analyze toll receptor-2 and -4, interleukin-6 and -8, tumor necrosis factor-α, leptin, ghrelin, insulin-like growth factor-1 and -2, hepatocyte growth factor, hepatocyte growth factor receptor and insulin receptor (IR). Read More

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http://dx.doi.org/10.1515/jpm-2018-0290DOI Listing

Skin pathologies in pregnancy.

J Perinat Med 2019 Mar 20. Epub 2019 Mar 20.

Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Progesterone is a hormone responsible for pregnancy maintenance and the amount of progesterone increases in a woman's body during pregnancy, as well as the level of female sex hormones, estrogens are also upregulated. Due to these changes the cutaneous sensitivity to external stimuli (meteorological factors, bacteria, etc.) increases. Read More

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http://dx.doi.org/10.1515/jpm-2018-0338DOI Listing
March 2019
3 Reads

Maternal serum endocan concentrations are elevated in patients with preterm premature rupture of membranes.

J Perinat Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Histology and Embryology, Gaziantep University School of Medicine, Gaziantep, Turkey.

Objectives To evaluate the maternal serum endocan levels in pregnant women complicated by preterm premature rupture of membranes (PPROM) and to compare the results with healthy pregnancies. Methods This cohort study included 31 pregnant women with PPROM and 34 gestational age-matched healthy subjects in the third trimester of pregnancy. The blood for analysis was obtained on the day of diagnosis and serum endocan levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Read More

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http://dx.doi.org/10.1515/jpm-2018-0401DOI Listing
March 2019
3 Reads

Impact of cell-free fetal DNA on invasive prenatal diagnostic tests in a real-world public setting.

J Perinat Med 2019 Mar 8. Epub 2019 Mar 8.

Fetal Medicine Unit, Maternal and Child Health and Development Network (SAMID), Department of Obstetrics and Gynaecology, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre (Imas12), Universidad Complutense de Madrid, Madrid, Spain.

Objective To evaluate the impact of cell-free fetal DNA (cfDNA) test on the number of invasive tests carried out in a public hospital that does not include this test in its services. Methods This was a retrospective cohort study in singleton pregnancies with a high risk (>1:270) on the first-trimester screening for aneuploidies. The options of performing an invasive test or a cfDNA test were explained to all women, the latter being especially recommended to those with a 1:50-1:270 risk (Group 1). Read More

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http://dx.doi.org/10.1515/jpm-2018-0410DOI Listing
March 2019
1 Read

Patients with acute cervical insufficiency without intra-amniotic infection/inflammation treated with cerclage have a good prognosis.

J Perinat Med 2019 Mar 8. Epub 2019 Mar 8.

Department of Obstetrics and Gynecology, Faculty of Medicine, Universidad de los Andes, Las Condes, Santiago, Chile.

Background The frequency of intra-amniotic infection/inflammation (IAI/I) in patients with midtrimester cervical insufficiency is up to 50%. Our purpose was to determine the perinatal outcomes of cervical cerclage in patients with acute cervical insufficiency with bulging membranes, and to compare the admission-to-delivery interval and pregnancy outcomes according to the results of amniotic fluid (AF) analysis and cerclage placement. Methods This was a retrospective cohort study including singleton pregnancies with cervical insufficiency between 15 and 26. Read More

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http://dx.doi.org/10.1515/jpm-2018-0388DOI Listing
March 2019
4 Reads

Characterization of fetal monocytes in preeclampsia and fetal growth restriction.

J Perinat Med 2019 Mar 1. Epub 2019 Mar 1.

University of Sydney, Sydney Medical School, Sydney, NSW, Australia.

Background There is little available data on fetal monocyte phenotype and function. A prospective cross-sectional pilot study was conducted to describe the cord blood monocyte subset phenotype in preeclampsia (PE) and fetal growth restriction (FGR) as compared to normal pregnancy and maternal circulation. Methods Maternal and cord blood samples from 27 pregnancies were collected at delivery from normal pregnancy, PE, FGR and PE+FGR. Read More

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http://dx.doi.org/10.1515/jpm-2018-0286DOI Listing
March 2019
1 Read

Effects of maternal obesity, excessive gestational weight gain and fetal macrosomia on the frequency of cesarean deliveries among migrant and non-migrant women - a prospective study.

J Perinat Med 2019 Feb 28. Epub 2019 Feb 28.

Department of Gynecology, Charité University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany.

Background Maternal obesity, excessive gestational weight gain and fetal macrosomia may affect the health of the mother and the newborn, and are associated with cesarean delivery. Pregnant women with a migration background have a higher risk of obesity but nevertheless a lower frequency of cesarean deliveries than women from the majority population. This study assesses which of these factors most influence the risk of a cesarean delivery and whether their prevalence can explain the lower cesarean rates in migrant women. Read More

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http://dx.doi.org/10.1515/jpm-2018-0399DOI Listing
February 2019
1 Read

Clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies.

J Perinat Med 2019 Feb 28. Epub 2019 Feb 28.

Division of Perinatology, Department of Obstetrics and Gynecology, Ankara, Turkey.

Objective To demonstrate clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies. Methods We retrospectively evaluated 75-g GTT screening results of 356 pregnancies without prompt diagnosis of gestational diabetes mellitus (GDM) between January 2013 and December 2017. Newborns with a birthweight greater than the 90th percentile were evaluated as LGA. Read More

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http://dx.doi.org/10.1515/jpm-2018-0373DOI Listing
February 2019
1 Read

The value of amniotic fluid analysis in patients with suspected clinical chorioamnionitis.

J Perinat Med 2019 Feb 28. Epub 2019 Feb 28.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Florida College of Medicine, PO Box 100294, Gainesville, FL 32610-0294, USA, Tel.: (352) 273-7562, Fax: (352) 294-5094.

Objective To assess the value of incorporating amniotic fluid (AF) analysis in the management of patients with clinical chorioamnionitis. Methods This was a retrospective cohort study of all women carrying a singleton fetus and managed at our center between 2000 and 2009. We included only those women suspected of chorioamnionitis based on one or more of the following: (1) uterine tenderness, (2) maternal fever, (3) maternal and/or fetal tachycardia and (4) purulent discharge. Read More

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http://dx.doi.org/10.1515/jpm-2018-0306DOI Listing
February 2019
1 Read

Assessment of maternal GBS colonization and early-onset neonatal disease rate for term deliveries: a decade perspective.

J Perinat Med 2019 Feb 28. Epub 2019 Feb 28.

Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Affiliated with the Hebrew University Medical School of Jerusalem, Jerusalem, Israel.

Objective To assess the maternal group B streptococcal (GBS) colonization rate and neonatal early-onset GBS (EOGBS) disease in term deliveries, a decade apart. Methods This was a retrospective computerized study between 2005 and 2016. A universal GBS culture-based approach gradually replaced the GBS risk-oriented screening. Read More

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http://www.degruyter.com/view/j/jpme.ahead-of-print/jpm-2018
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http://dx.doi.org/10.1515/jpm-2018-0293DOI Listing
February 2019
3 Reads

Gestational age-related changes in shear wave speed of the uterine cervix in normal pregnancy at 12-35 weeks' gestation.

J Perinat Med 2019 Mar 1. Epub 2019 Mar 1.

Department of Obstetrics and Gynecology, School of Medicine, Kurume University, Kurume, Japan.

Background This study aimed to analyze age-related changes in shear wave speed (SWS) of the normal uterine cervix. Methods We studied 362 women with a normal singleton pregnancy at 12-35 weeks' gestation. The SWS of the cervix was measured using transvaginal ultrasonography at the internal os region of the anterior cervix (IOA), posterior cervix (IOP) and cervical canal (IOC), and at the external os region of the anterior cervix (EOA), posterior cervix (EOP) and cervical canal (EOC). Read More

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http://dx.doi.org/10.1515/jpm-2018-0250DOI Listing

Association of maternal disease and medication use with the risk of congenital heart defects in offspring: a case-control study using logistic regression with a random-effects model.

J Perinat Med 2019 Feb 22. Epub 2019 Feb 22.

National Center for Birth Defect Monitoring, Department of Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Objective To examine the association between maternal diseases and congenital heart defects (CHDs) and to evaluate whether those associations vary with corresponding medication use. Methods A multi-hospital case-control study conducted from February 2010 to December 2014 analysed 916 controls and 1236 cases. Participating mothers were asked whether they suffered from influenza, common cold, herpes and threatened abortion or had used corresponding medication during the periconception period or the early pregnancy period. Read More

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http://dx.doi.org/10.1515/jpm-2018-0281DOI Listing
February 2019
1 Read

Erythropoietin in perinatal hypoxic-ischemic encephalopathy: a systematic review and meta-analysis.

J Perinat Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Orthopedics, Bhimrao Ambedkar University, Agra, UP, India.

Background Erythropoietin (EPO) appears to confer neuroprotection to the injured brain. Randomized clinical trials (RCTs) have demonstrated its safety in neonates with hypoxic-ischemic encephalopathy (HIE); however, the evidence is unclear. The objective of this study was to examine the role of EPO in perinatal HIE by a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1515/jpm-2018-0360DOI Listing
February 2019
1 Read

An exploratory study into social and healthcare variables of maternal mortality: a case-control study.

J Perinat Med 2019 Feb 21. Epub 2019 Feb 21.

Deputy of Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Background Regarding the important role the mothers' health plays in shaping nations' well-being, this study endeavored to explore the main social and healthcare factors related to maternal mortality. Methods In this case-control study, data (viz., all maternal mortalities) were gathered from the national maternal mortality surveillance system. Read More

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http://dx.doi.org/10.1515/jpm-2018-0334DOI Listing
February 2019
2 Reads

Mesenchymal stromal cells and TGF-β1 in tracheal aspirate of premature infants: early predictors for bronchopulmonary dysplasia?

J Perinat Med 2019 Feb 21. Epub 2019 Feb 21.

Division of Neonatology, Department of Pediatrics, Cairo University Children's Hospital, Cairo, Egypt.

Background The pathogenesis of bronchopulmonary dysplasia (BPD) includes arrest of alveolar septation and enhanced fibrosis. We hypothesized that mesenchymal stromal cells (MSC) and transforming growth factor-β1 (TGF-β1) in tracheal aspirates of mechanically ventilated premature infants differ in BPD and non-BPD infants. Methods Tracheal aspirates were collected during the first week of life. Read More

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http://dx.doi.org/10.1515/jpm-2018-0305DOI Listing
February 2019
1 Read

Neurological development may be accelerated in growth-restricted fetuses: a 4D ultrasound study.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Perinatology and Gynecology, Kagawa University Graduate School of Medicine, Miki, Kagawa, Japan.

Objective To assess whether neurological maturation and development are accelerated in fetal growth restriction (FGR) in utero using four-dimensional (4D) ultrasound. Methods The facial expressions of 50 appropriate-for-gestational-age (AGA) and 34 FGR fetuses aged between 28 and 35 gestational weeks were assessed using 4D ultrasound. Subsequently, they were differentiated into two gestational age groups (19 aged 28-31 weeks and 31 aged 32-35 weeks in AGA, and 15 aged 28-31 weeks and 19 aged 32-35 weeks in FGR). Read More

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http://dx.doi.org/10.1515/jpm-2018-0379DOI Listing
February 2019
1 Read

A high concentration of fetal fibronectin in cervical secretions increases the risk of intra-amniotic infection and inflammation in patients with preterm labor and intact membranes.

J Perinat Med 2019 Apr;47(3):288-303

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Objective To determine whether the risk of intra-amniotic infection/inflammation and spontaneous preterm delivery (SPTD) varies as a function of the concentration of cervical fetal fibronectin (fFN) in patients with preterm labor and intact membranes. Methods This prospective study included 180 patients with preterm labor and intact membranes who had a sample collected for quantitative fFN measurement and underwent amniocentesis. Amniotic fluid was cultured for aerobic and anaerobic bacteria and genital mycoplasmas. Read More

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http://dx.doi.org/10.1515/jpm-2018-0351DOI Listing
April 2019
2 Reads

Reference range of fetal myocardial area by three-dimensional ultrasonography and its applicability in fetuses of pre-gestational diabetic women.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo-SP, Brazil.

Objectives To determine the reference range for the myocardial area in healthy fetuses using three-dimensional (3D) ultrasonography and validate these results in fetuses of pregnant women with pre-gestational diabetes mellitus (DM). Methods This cross-sectional retrospective study included 168 healthy pregnant women between gestational weeks 20 and 33+6 days. The myocardial area was measured using spatio-temporal image correlation (STIC) in the four-chamber view. Read More

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http://dx.doi.org/10.1515/jpm-2018-0342DOI Listing
February 2019

Fetal abdominal cysts: antenatal course and postnatal outcomes.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK.

Background There is little information on which to base the prognostic counselling as to whether an antenatally diagnosed fetal abdominal cyst will grow or shrink, or need surgery. This study aims to provide contemporary data on prenatally diagnosed fetal abdominal cysts in relation to their course and postnatal outcomes. Methods Fetal abdominal cysts diagnosed over 11 years in a single centre were identified. Read More

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http://dx.doi.org/10.1515/jpm-2018-0311DOI Listing
February 2019
1 Read

Twin anemia-polycythemia sequence and routine monitoring practices amongst maternal-fetal medicine specialists in the United States: an initial investigation.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Kent State University, College of Public Health, Kent, OH, USA.

Background The purpose of this initial investigation was to begin to understand the routine twin anemia-polycythemia sequence (TAPS) monitoring practices of maternal-fetal medicine specialists (MFM specialists) in the United States in the absence of a formal guideline. Methods This study used an anonymous, online survey of 90 MFM specialists who were practicing in the United States. A $5 gift card to an online store was used to incentivize participants. Read More

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http://dx.doi.org/10.1515/jpm-2018-0240DOI Listing
February 2019
1 Read

Behcet's disease and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 12 million births.

J Perinat Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

Background Behcet's disease (BD) is a rare, multi-systemic inflammatory disorder for which only limited and contradictory data exists in the context of pregnancy. Our objective was to estimate the prevalence of BD in pregnancy and to evaluate maternal and fetal outcomes associated with pregnant women living with BD. Methods Using the 1999-2013 Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from the United States, we performed a population-based retrospective cohort study consisting of pregnancies that occurred during this time period. Read More

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http://dx.doi.org/10.1515/jpm-2018-0161DOI Listing
February 2019
1 Read

Metabolic characterization of amniotic fluids of fetuses with enlarged nuchal translucency.

J Perinat Med 2019 Apr;47(3):311-318

Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy, Ospedale Microcitemico, Via E. Jenner n/n, 09121 Cagliari, Italy.

Background In prenatal diagnosis, a thickened nuchal translucency (NT) is one of the most sensitive and specific markers for several defects but it may also be found in 5% of healthy fetuses. The pathophysiological causes that lead to an increase in NT are not yet fully understood. Metabolomics represents a new promising approach, useful for studying different metabolites in biological organisms in response to environmental stressors. Read More

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http://dx.doi.org/10.1515/jpm-2018-0314DOI Listing
April 2019
1 Read

Identification of growth patterns of preterm and small-for-gestational age children from birth to 4 years - do they catch up?

J Perinat Med 2019 Feb 13. Epub 2019 Feb 13.

Center for Medicine and Society, University of Freiburg, Freiburg, Germany.

Background A legitimate indication for growth hormone (GH) therapy in children born too light or short at birth [small-for-gestational age (SGA)] exists in Germany and the European Union only if special criteria are met. Methods We conducted a longitudinal, multi-centered study on full-term appropriate-for-gestational age (AGA, n=1496) and pre-term born SGA (n=173) and full-term SGA children (n=891) in Germany from 2006 to 2010. We analyzed height, weight, body mass index (BMI) and head circumference. Read More

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http://dx.doi.org/10.1515/jpm-2018-0239DOI Listing
February 2019
1 Read

Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α and spontaneous preterm delivery in singleton pregnancies.

J Perinat Med 2019 Apr;47(3):304-310

Faculty of Medicine, Department of Obstetrics and Gynecology, University of Koc, İstanbul, Turkey.

Background We investigated the roles of inflammatory cytokines and the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family in the etiopathogenesis of spontaneous preterm delivery by comparing the ADAMTS4, ADAMTS5, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) levels in second-trimester amniotic fluid between pregnant women with preterm birth and term controls. Methods All pregnant women who underwent second-trimester amniocentesis for genetic analysis between January 1, 2016, and January 1, 2018, were enrolled in this study. From this cohort, 22 patients who subsequently experienced spontaneous preterm delivery before 34 weeks of pregnancy formed the study group, and 22 age- and body mass index (BMI)-matched patients without preterm birth constituted the control group. Read More

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http://dx.doi.org/10.1515/jpm-2018-0297DOI Listing
April 2019
2 Reads

Continuous infusion vs. intermittent flushing of peripheral cannulas in neonates using a needleless connector: a prospective cohort study.

J Perinat Med 2019 Feb 7. Epub 2019 Feb 7.

Neonatal Intensive Care Unit, Ghent University Hospital, Ghent, Belgium.

Objective To compare the duration of patency of peripheral intravenous cannulas between continuous infusion and intermittent flushing, while using a needleless intravenous connector in newborns admitted to the neonatal intensive care unit (NICU). Methods This is a prospective cohort study, including neonates admitted to the NICU who needed a peripheral intravenous cannula for intermittent administration of intravenous medication. In the first period, neonates received continuous peripheral infusion with NaCl 0. Read More

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http://dx.doi.org/10.1515/jpm-2018-0285DOI Listing
February 2019
7 Reads

Ultrasound Doppler waveform assessment: the story continues.

J Perinat Med 2019 Feb;47(2):139-141

Lenox Hill Hospital, Northwell Health, New York, NY, USA.

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http://dx.doi.org/10.1515/jpm-2018-0387DOI Listing
February 2019

Impact of the new guidelines on the management of premature rupture of membranes for the prevention of late preterm birth: an 11-year retrospective study.

J Perinat Med 2019 Apr;47(3):341-346

Obstetrics Service, Department of Obstetrics and Gynecology, Geneva University Hospitals, Geneva, Switzerland.

Objectives To evaluate the number of late preterm (LPT) births (between 34 0/7 and 36 6/7 weeks) that could have been prevented if expectant management of preterm premature rupture of membranes (PPROM) had been applied according to new recommendations. Methods A retrospective cohort study included all births at one Swiss center between January 1, 2002 and December 31, 2012. Births were categorized using an adapted evidence-based classification. Read More

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http://dx.doi.org/10.1515/jpm-2018-0324DOI Listing
April 2019
2 Reads

Prenatal diagnosis, associated findings and postnatal outcome of fetuses with double outlet right ventricle (DORV) in a single center.

J Perinat Med 2019 Apr;47(3):354-364

Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany.

Objective To assess the spectrum of associated anomalies, the intrauterine course, postnatal outcome and management of fetuses with double outlet right ventricle (DORV). Methods All cases of DORV diagnosed prenatally over a period of 8 years were retrospectively collected in a single tertiary referral center. All additional prenatal findings were assessed and correlated with the outcome. Read More

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http://dx.doi.org/10.1515/jpm-2018-0316DOI Listing
April 2019
1 Read

Dependencies between maternal and fetal autonomic tone.

J Perinat Med 2019 Apr;47(3):323-330

Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.

Background Disturbances in maternal physiology can cause changes in the fetal condition that may lead to impaired fetal development. Synchronous monitoring of cardiac autonomic tone via the assessment of the fetal and maternal heart rate (HR) and heart rate variability (HRV) may provide an appropriate diagnostic window. Methods Partial rank correlation coefficients between the maternal and fetal HR and HRV indices were calculated and verified by testing surrogate data in 315 magnetocardiographic (MCG) recordings from 141 healthy women pregnant with singleton fetuses [18+6 to 39+2 weeks gestational age (WGA)]. Read More

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http://dx.doi.org/10.1515/jpm-2018-0221DOI Listing

Diabetes and obesity during pregnancy are associated with oxidative stress genotoxicity in newborns.

J Perinat Med 2019 Apr;47(3):347-353

Materno-Fetal Medicine Unit, Obstetrics and Gynecology Department, Hospital General de México Eduardo Liceaga O.D., Mexico City, Mexico.

Objective To compare the level of oxidative deoxyribonucleic acid (DNA) damage (genotoxicity) between the offspring of mothers with and without diabetes diagnosed during pregnancy and its association with maternal body mass index (BMI). Methods We measured 8-hydroxy-deoxyguanosine (8-OH-dG), a marker of DNA oxidative damage, in venous umbilical cord plasma from newborns of mothers with (n=34) and without (n=56) diabetes diagnoses obtained during pregnancy. Two markers of oxidative stress - namely, nitric oxide degradation products (NOx) and total glutathione (GSH) - were quantified in both mothers and newborns. Read More

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http://dx.doi.org/10.1515/jpm-2018-0201DOI Listing

Customised birthweight standard for a Slovenian population.

J Perinat Med 2019 Apr;47(3):270-275

Perinatal Institute, Birmingham, UK.

Objective To produce a customised birthweight standard for Slovenia. Methods This retrospective study used a cohort from the National Perinatal Information System of Slovenia (NPIS). Prospectively collected information from pregnancies delivered in all of Slovenia's 14 maternal hospitals between 1st January 2003 and 31st December 2012 was included. Read More

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http://dx.doi.org/10.1515/jpm-2018-0219DOI Listing
April 2019
3 Reads

Therapeutic hypothermia during neonatal transport at Regional Perinatal Centers: active vs. passive cooling.

J Perinat Med 2019 Apr;47(3):365-369

Pediatrics, Division of Neonatology, New York University Medical Center, New York, NY, USA.

Background Earlier initiation of therapeutic hypothermia in term infants with hypoxic-ischemic encephalopathy has been shown to improve neurological outcomes. The objective of the study was to compare safety and effectiveness of servo-controlled active vs. passive cooling used during neonatal transport in achieving target core temperature. Read More

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http://dx.doi.org/10.1515/jpm-2018-0302DOI Listing
April 2019
5 Reads

Placental thickness on ultrasound and neonatal birthweight.

J Perinat Med 2019 Apr;47(3):331-334

Penn State Hershey Medical Center, Division of Maternal Fetal Medicine, Hershey, PA, USA.

Objective To investigate the relationship between maximal placental thickness during routine anatomy scan and birthweight at delivery. Methods This retrospective descriptive study analyzed 200 term, singleton deliveries in 2016 at Penn State Hershey Medical Center. We measured maximal placental thickness in the sagittal plane from the ultrasound images of the placenta obtained at the 18-21-week fetal anatomy screen. Read More

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http://dx.doi.org/10.1515/jpm-2018-0100DOI Listing
April 2019
2 Reads

Stillbirths in women with pre-gravid obesity.

J Perinat Med 2019 Apr;47(3):319-322

Department of Obstetrics and Gynecology, Kaplan Medical Center, affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Rehovot, Israel.

Objective To determine the association between pre-gravid obesity and stillbirth. Methods A retrospective study of a population-based dataset of births at ≥34 weeks' gestation. We excluded fetal deaths due to lethal anomalies and intrapartum fetal deaths. Read More

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http://www.degruyter.com/view/j/jpme.ahead-of-print/jpm-2018
Publisher Site
http://dx.doi.org/10.1515/jpm-2018-0266DOI Listing
April 2019
14 Reads

Doppler evaluation of the fetal pulmonary artery pressure.

J Perinat Med 2019 Feb;47(2):218-221

Unidad de Diagnostico Perinatal (UDP)-Centro Policlínico Valencia (CPV), Valencia, Venezuela.

Background The Doppler effect has allowed the characterization of several vessels in maternal-fetal circulation that have been used for practical purposes. Our review of the literature showed a paucity of information about fetal pulmonary artery pressure (FMPAP) and its behavior in regard to gestational age (GA). The objectives of the study were to evaluate a formula to calculate the main FMPAP and its correlation with GA. Read More

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http://dx.doi.org/10.1515/jpm-2018-0112DOI Listing
February 2019
1 Read

Fetal anomalies - From prenatal diagnosis to therapy.

J Perinat Med 2018 Nov;46(9):951-952

MD, FRCOG, FACOG, MBA, Professor of Obstetrics and Gynecology, Medical Director and CEO, University Medical Center Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany, Tel.: +49 228.287-10900, Fax: +49 228.287-90 10900, Mobile: +49 151.58 233 667,

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http://dx.doi.org/10.1515/jpm-2018-0333DOI Listing
November 2018
1 Read

Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation.

J Perinat Med 2019 Apr;47(3):276-287

Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.

Background The inflammasome has been implicated in the mechanisms that lead to spontaneous labor at term. However, whether the inflammasome is activated in the amniotic cavity of women with clinical chorioamnionitis at term is unknown. Herein, by measuring extracellular ASC [apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (CARD)], we investigated whether there is in vivo inflammasome activation in amniotic fluid of patients with clinical chorioamnionitis at term with sterile intra-amniotic inflammation and in those with intra-amniotic infection. Read More

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http://www.degruyter.com/view/j/jpme.ahead-of-print/jpm-2018
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http://dx.doi.org/10.1515/jpm-2018-0271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445729PMC
April 2019
12 Reads
1.425 Impact Factor

Update on uterine tachysystole.

J Perinat Med 2019 Feb;47(2):152-160

Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, ON, Canada.

Uterine tachysystole (TS) is a potentially significant intrapartum complication seen most commonly in induced or augmented labors but may also occur in women with spontaneous labor. When it occurs, maternal and perinatal complications can arise if not identified and managed promptly by obstetric care providers. Over recent years, new definitions of the condition have facilitated further research into the field, which has been synthesized to inform clinical management guidelines and protocols. Read More

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http://dx.doi.org/10.1515/jpm-2018-0175DOI Listing
February 2019
9 Reads

Antenatal magnesium sulfate for fetal neuroprotection: a critical appraisal and systematic review of clinical practice guidelines.

J Perinat Med 2019 Apr;47(3):262-269

Sidra Medicine, Department of OBGYN, Weill Cornell Medical College-Qatar, Qatar Foundation, PO Box 26999, Doha, Qatar.

Background Magnesium sulfate is an accepted intervention for fetal neuroprotection. There are some perceived differences in the international recommendations on the use magnesium sulfate for fetal neuroprotection in preterm labor. Content This systematic review analyses the available clinical guidelines for the use of magnesium sulfate for fetal neuroprotection and compares the recommendations, and assesses the quality of guidelines. Read More

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http://dx.doi.org/10.1515/jpm-2018-0174DOI Listing
April 2019
2 Reads
1.430 Impact Factor

Small for gestational age and extremely low birth weight infant outcomes.

J Perinat Med 2019 Feb;47(2):247-251

MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.

Background Small for gestational age (SGA) infants are less likely to develop respiratory distress syndrome (RDS), but more likely to develop bronchopulmonary dysplasia (BPD) and have a higher mortality. Our aim was to focus on outcomes of those with a birth weight less than or equal to 750 g. Methods The mortality, BPD severity, necrotising enterocolitis (NEC), home oxygen requirement and length of hospital stay were determined according to SGA status of all eligible infants in a 5-year period admitted within the first 24 h after birth. Read More

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http://dx.doi.org/10.1515/jpm-2018-0295DOI Listing
February 2019
1 Read

Effect of n-3 long-chain polyunsaturated fatty acids supplementation in healthy mothers on DHA and EPA profiles in maternal and umbilical blood: a randomized controlled trial.

J Perinat Med 2019 Feb;47(2):200-206

Department of Surgery, Mostar Clinical Hospital Center, School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina.

Background The objective of the study was to compare the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) dietary supplementation on their concentration in total lipids (TL) and lipid fractions of maternal and umbilical vein (UV) blood. The specific objective was to analyze the impact of EPA and DHA supplementation on pregnancy outcome and neonatal birth weight. Methods Women were randomly single-blinded (randomized controlled trial; ISRCTN36705743) allocated to the group receiving EPA and DHA supplementation (supplemented group) or the group receiving placebo-corn oil (control group) in the time period from January 1st, 2016 until March 1st, 2017. Read More

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http://www.degruyter.com/view/j/jpme.ahead-of-print/jpm-2018
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http://dx.doi.org/10.1515/jpm-2018-0155DOI Listing
February 2019
5 Reads

Antecedents of red cell transfusion in a large contemporary obstetric cohort.

J Perinat Med 2019 Feb;47(2):195-199

Rotunda Hospital, Parnell Square, Dublin 1, Ireland.

Background Hemorrhage is a critical contributor to maternal morbidity but estimation of blood loss at delivery is frequently inaccurate. Due to this inaccuracy we sought to examine blood transfusion as a surrogate marker for morbidity in a large non-population based consecutive cohort. Methods A retrospective analysis of prospectively gathered data was carried out at two university institutions serving a heterogeneous urban obstetric population from January to December 2016. Read More

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http://www.degruyter.com/view/j/jpme.ahead-of-print/jpm-2018
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http://dx.doi.org/10.1515/jpm-2018-0227DOI Listing
February 2019
11 Reads

Birth risks according to maternal height and weight - an analysis of the German Perinatal Survey.

J Perinat Med 2018 Dec;47(1):50-60

University of Alberta, Department of Medicine, Division of Preventive Medicine, Edmonton, Alberta, Canada.

Objective To investigate the variability in the prevalences of selected birth risks in women of different heights and weights. Methods Data from the German Perinatal Survey of 1998-2000 were analyzed: 503,468 cases contributed to our analysis of the prevalences of selected birth risks specified according to maternal weight groups, 502,562 cases contributed to our analysis according to maternal height groups and 43,928 cases contributed to our analysis of birth risks in women with a body mass index (BMI) of 21-23 kg/m2 but different heights and weights. Data analysis was performed using SPSS version 22. Read More

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http://dx.doi.org/10.1515/jpm-2017-0038DOI Listing
December 2018
7 Reads

What's new in the multiple gestations literature?

J Perinat Med 2018 Oct;46(8):823-824

Jefferson Medical College of Thomas Jefferson University, Department of Obstetrics and Gynecology, 833 Chestnut St., First Floor, Philadelphia, PA 19107, USA, Tel.: +2159557996, Fax: +(215) 955-5041.

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http://dx.doi.org/10.1515/jpm-2018-0304DOI Listing
October 2018
9 Reads

Mechanisms of death in structurally normal stillbirths.

J Perinat Med 2019 Feb;47(2):222-240

Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.

Objectives To investigate mechanisms of in utero death in normally formed fetuses by measuring amniotic fluid (AF) biomarkers for hypoxia (erythropoietin [EPO]), myocardial damage (cardiac troponin I [cTnI]) and brain injury (glial fibrillary acidic protein [GFAP]), correlated with risk factors for fetal death and placental histopathology. Methods This retrospective, observational cohort study included intrauterine deaths with transabdominal amniocentesis prior to induction of labor. Women with a normal pregnancy and an indicated amniocentesis at term were randomly selected as controls. Read More

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http://dx.doi.org/10.1515/jpm-2018-0216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349478PMC
February 2019
22 Reads
1.430 Impact Factor

Vitamin A and β-carotene in pregnant and breastfeeding post-bariatric women in an urban population.

J Perinat Med 2019 Feb;47(2):183-189

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Washington-Seattle, Seattle, WA, USA.

Background As breastfeeding awareness and social acceptance are increased, maternal nutritional deficiency requires more investigation. Methods A prospective cohort study was conducted to determine if vitamin A deficiency is more common in pregnant, lactating post-bariatric surgery women in an inner city population. Antepartum, women after bariatric surgery and controls with no history of malabsorption were recruited. Read More

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http://dx.doi.org/10.1515/jpm-2018-0142DOI Listing
February 2019
7 Reads

The diagnostic value of a detailed first trimester anomaly scan in fetuses with increased nuchal translucency thickness.

Authors:
Ismail Tekesin

J Perinat Med 2019 Feb;47(2):241-246

Prenatal Unit Stuttgart, Alte Poststr. 3, D-70173 Stuttgart, Germany, Tel.: +497114006010, Fax: +4971140060120.

Objectives To assess the diagnostic value of an early anomaly scan in fetuses with increased nuchal translucency (NT) in the prediction of aneuploidy. Methods In this study we analyzed the data of pregnant women obtained at their first trimester screening in our unit. The detailed examination routinely includes measurement of NT and a scan for anatomical defects. Read More

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http://dx.doi.org/10.1515/jpm-2018-0145DOI Listing
February 2019
2 Reads