78,597 results match your criteria Journal of Perinatal & Neonatal Nursing[Journal]


Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

St. Vincent's Institute of Medical Research.

Mutations in subunits of the cilia-specific cytoplasmic Dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs), characterized by impaired bone growth and life-threatening perinatal respiratory complications. Different SRTD mutations result in varying disease severities. It remains unresolved whether this reflects the extent of retained hypomorphic protein functions or relative importance of the affected subunits for the activity of the CD2 holoenzyme. Read More

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http://dx.doi.org/10.1093/hmg/ddz083DOI Listing

Arterial and venous complications after fertility treatment: A French nationwide cohort study.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 11;237:57-63. Epub 2019 Mar 11.

The French Public Health Agency, Non-Communicable Disease and Trauma Division, Saint-Maurice, France.

Objectives: To determine whether the risk of thromboembolic complications is higher in women following unsuccessful fertility treatment (FT) and in pregnant women following successful FT, and whether the risk differs according to FT type.

Study Design: This is an observational prospective cohort study. All French women aged 18-45 years who received FT between 2013 and 2015 were selected from the French health insurance claim database which registers healthcare consumption for the entire French population. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.02.034DOI Listing
March 2019
1 Read

Primary Fetal Pleural Effusion: Characteristics, Outcomes and the Role of Intervention.

Prenat Diagn 2019 Apr 22. Epub 2019 Apr 22.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.

Background: We aimed to present the natural history and outcomes of fetal primary pleural effusions (PPE).

Methods: Fetuses with prenatal diagnosis of PPE, delivered between January 2011 and June 2018 were included. Fetal PPE were separated into groups: resolved, stable or progressive. Read More

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http://dx.doi.org/10.1002/pd.5462DOI Listing

High-Frequency Heart Rate Variability Index: A Prospective, Observational Trial Assessing Utility as a Marker for the Balance Between Analgesia and Nociception Under General Anesthesia.

Anesth Analg 2019 Apr 17. Epub 2019 Apr 17.

Perinatal Environment and Health, Faculté of Médicine, University of Lille, Centre Hospitalier Universitaire, Lille, France.

Background: Maintaining a balance between nociception and analgesia perioperatively reduces morbidity and improves outcomes. Current intraoperative analgesic strategies are based on subjective and nonspecific parameters. The high-frequency heart rate (HR) variability index is purported to assess the balance between nociception and analgesia in patients under general anesthesia. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004180DOI Listing

Symposium on "parental education" at the ICCH17.

Int J Circumpolar Health 2019 Dec;78(1):1604062

a Centre for Public Health in Greenland, National Institute of Public Health , University of Southern Denmark , Copenhagen , Denmark.

This symposium report provides a brief overview of the six programmes and studies on parental education and maternal health services within the circumpolar region presented in the symposium "parental education" at the 17th International Congress of Circumpolar Health in Copenhagen, Denmark, August 2018. Read More

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http://dx.doi.org/10.1080/22423982.2019.1604062DOI Listing
December 2019

Fetal echocardiographic prediction score for perinatal mortality of tricuspid valve malformation and Ebstein anomaly.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Pediatric Cardiology, Osaka Women's and Children's Hospital, Osaka, Japan.

Objectives: Tricuspid valve malformation and Ebstein anomaly (TVM/EA) diagnosed by fetal echocardiography show a wide variety of clinical severity and prognosis. Celermajer index and Simpson Andrews Sharland (SAS) scores were previously reported as predictive scores for the prognosis in cases of TVM/EA; however, they do not reflect the hemodynamic impact of left ventricular function, which has been recently considered as important in TVM/EA physiology. In this study, we aimed to identify better predicting parameters and develop a scoring system that includes left ventricular function. Read More

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http://dx.doi.org/10.1002/uog.20302DOI Listing

Renal Oxidative Stress and Inflammatory Response in Perinatal Cyclosporine-A Exposed Rat Progeny and its Relation to Gender.

J Microsc Ultrastruct 2019 Jan-Mar;7(1):44-49

Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Background And Aim Of The Work: The current study postulated that cyclosporine A (CSA) could induce gender-specific renal damage. Hence, the current study aims to investigate the nephrotoxic effect of perinatal exposure of male and female rat progeny to CSA. Moreover, it aims to evaluate the oxidative stress and inflammation as a possible pathophysiologic mechanism. Read More

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http://dx.doi.org/10.4103/JMAU.JMAU_52_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442325PMC

Hypertension in pregnancy: Pathophysiology and treatment.

SAGE Open Med 2019 10;7:2050312119843700. Epub 2019 Apr 10.

Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.

Hypertensive disorders of pregnancy, an umbrella term that includes preexisting and gestational hypertension, preeclampsia, and eclampsia, complicate up to 10% of pregnancies and represent a significant cause of maternal and perinatal morbidity and mortality. Despite the differences in guidelines, there appears to be consensus that severe hypertension and non-severe hypertension with evidence of end-organ damage need to be controlled; yet the ideal target ranges below 160/110 mmHg remain a source of debate. This review outlines the definition, pathophysiology, goals of therapy, and treatment agents used in hypertensive disorders of pregnancy. Read More

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http://dx.doi.org/10.1177/2050312119843700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458675PMC

[External anthropometric measurement and pelvimetry among nulliparous women in Lubumbashi: risk factors and predictive score of mechanical dystocia].

Pan Afr Med J 2018 2;31:69. Epub 2018 Oct 2.

Département de Gynécologie-Obstétrique, Faculté de Médecine, Université de Lubumbashi, Lubumbashi, République Démocratique du Congo.

Introduction: Maternal and perinatal morbi-mortality is higher in most of sub-Saharan Africa compared to the rest of the world. All women at risk for mechanical dystocia should be screened before labor and referred to a better equipped Hospital for childbirth. This would reduce morbi-mortality. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.69.16014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457727PMC
October 2018

Perspectives and experiences of healthcare professionals regarding the medicalisation of pregnancy and childbirth.

Women Birth 2019 Apr 7;32(2):e173-e181. Epub 2018 Jul 7.

Department of Sociology, Faculty of Arts, University of Maribor, Koroška cesta 160, 2000 Maribor, Slovenia.

Background: Pregnancy and childbirth hold broader cultural and societal implications and entail more than simply a natural event. Today, these otherwise natural phenomena are driven by the development of surveillance medicine in a risk-averse society. This affects how both healthcare professionals and women perceive medicalisation and is influencing changes in clinical practice surrounding childbirth. Read More

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http://dx.doi.org/10.1016/j.wombi.2018.06.018DOI Listing

Fetal movement frequency and the effect of associated perinatal factors: Multicenter study.

Women Birth 2019 Apr 28;32(2):127-130. Epub 2018 Jun 28.

Perinatal Center, Shiga University of Medical Science, Japan.

Background: Decreased fetal movements are associated with adverse perinatal outcomes, including stillbirth. Delayed maternal visits to a health care provider after perceiving decreased fetal movements are frequently observed in stillbirths. Informing pregnant women of the normal range of fetal movement frequency is essential in their earlier visits in order to prevent stillbirth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18715192183021
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http://dx.doi.org/10.1016/j.wombi.2018.06.010DOI Listing

Fear of childbirth and associated factors among low-risk pregnant women.

J Obstet Gynaecol 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

The aims of this study were to determine prevalence of childbirth fear among uncomplicated pregnant women in Siriraj Hospital and possible associated factors. A total of 305 uncomplicated, singleton pregnant women were enrolled during early third trimester. All participants were interviewed regarding baseline demographic, social, economic, family, and obstetric characteristics. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1584885DOI Listing
April 2019
1 Read

Prediction of adverse perinatal outcomes by fetal biometry: a comparison of customized and population-based standards.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS).

Objective: To compare the predictive ability of estimated fetal weight (EFW) percentiles, according to seven growth standards, to detect fetuses at risk for adverse perinatal outcomes.

Methods: This retrospective cohort study included 3,437 African-American women. Population-based (Hadlock, INTERGROWTH-21st, WHO, FMF), ethnic specific (NICHD), customized (GROW) and African American customized (PRB/NICHD) growth standards were applied to the last available scan prior to delivery. Read More

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http://dx.doi.org/10.1002/uog.20299DOI Listing

The UK's pandemic influenza research portfolio: a model for future research on emerging infections.

Lancet Infect Dis 2019 Apr 18. Epub 2019 Apr 18.

National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK.

The 2009 influenza A H1N1 pandemic was responsible for considerable global morbidity and mortality. In 2009, several research studies in the UK were rapidly funded and activated for clinical and public health actions. However, some studies were too late for their results to have an early and substantial effect on clinical care, because of the time required to call for research proposals, assess, fund, and set up the projects. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30786-2DOI Listing
April 2019
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Influenza and pertussis vaccination of women during pregnancy in Victoria, 2015-2017.

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

Monash University, Melbourne, VIC.

Objectives: To assess variations by time of year and hospital in the uptake of influenza and pertussis vaccinations by pregnant women in Victoria; to identify factors associated with vaccination uptake.

Design, Setting: Retrospective analysis of data in the Victorian Perinatal Data Collection (VPDC), a population surveillance system for obstetric conditions, procedures, and pregnancy and birth outcomes.

Participants: Women whose pregnancies ended in a live or stillbirth during July 2015 - June 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50125
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http://dx.doi.org/10.5694/mja2.50125DOI Listing
April 2019
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Age-Dependency of Levetiracetam Effects on Exocytotic GABA Release from Nerve Terminals in the Hippocampus and Cortex in Norm and After Perinatal Hypoxia.

Cell Mol Neurobiol 2019 Apr 20. Epub 2019 Apr 20.

The Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha Str, Kiev, 01030, Ukraine.

Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Read More

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http://dx.doi.org/10.1007/s10571-019-00676-6DOI Listing
April 2019
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Preterm birth and risk of sleep-disordered breathing from childhood into mid-adulthood.

Int J Epidemiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Family Medicine and Community Health.

Background: Preterm birth (gestational age <37 weeks) has previously been associated with cardiometabolic and neuropsychiatric disorders into adulthood, but has seldom been examined in relation to sleep disorders. We conducted the first population-based study of preterm birth in relation to sleep-disordered breathing (SDB) from childhood into mid-adulthood.

Methods: A national cohort study was conducted of all 4 186 615 singleton live births in Sweden during 1973-2014, who were followed for SDB ascertained from nationwide inpatient and outpatient diagnoses through 2015 (maximum age 43 years). Read More

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https://academic.oup.com/ije/advance-article/doi/10.1093/ije
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http://dx.doi.org/10.1093/ije/dyz075DOI Listing
April 2019
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Accuracy of mortality statistics in Palestine: a retrospective cohort study.

BMJ Open 2019 Apr 20;9(4):e026640. Epub 2019 Apr 20.

Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

Objective: To examine the accuracy of mortality statistics in Palestine, to identify gaps and to provide evidence-based recommendations to improve mortality statistics in Palestine.

Study Design And Setting: A retrospective death registry-based study that examined a stratified random sample of death notification forms (DNFs) of patients who died in hospitals in Palestine was reported in 2012. We randomly selected 600 deceased from the Cause of Death Registry: 400 from the West Bank and 200 from the Gaza Strip. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02664
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http://dx.doi.org/10.1136/bmjopen-2018-026640DOI Listing
April 2019
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Identification of earlier predictors of pregnancy complications through wearable technologies in a Brazilian multicentre cohort: Maternal Actigraphy Exploratory Study I (MAES-I) study protocol.

BMJ Open 2019 Apr 20;9(4):e023101. Epub 2019 Apr 20.

Social Medicine, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil.

Introduction: Non-invasive tools capable of identifying predictors of maternal complications would be a step forward for improving maternal and perinatal health. There is an association between modification in physical activity (PA) and sleep-wake patterns and the occurrence of inflammatory, metabolic, pathological conditions related to chronic diseases. The actigraphy device is validated to estimate PA and sleep-wake patterns among pregnant women. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023101DOI Listing

At the Forefront of Psychoneuroimmunology in Pregnancy: Implications for Racial Disparities in Birth Outcomes PART 1: Behavioral Risks Factors.

Authors:
Lisa M Christian

Neurosci Biobehav Rev 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychiatry & Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; The Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Psychology, The Ohio State University, Columbus, Ohio, USA; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

Birth prior to full term is a substantial public health issue. In the US, ˜400,000 babies per year are born preterm (< 37 weeks), while >1 million are early term (37-38 weeks). Birth prior to full term confers risk both immediate and long term, including neonatal intensive care, decrements in school performance, and increased mortality risk from infancy through young adulthood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01497634193033
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http://dx.doi.org/10.1016/j.neubiorev.2019.04.009DOI Listing
April 2019
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Maternal chorioamnionitis & long term neurological morbidity in the offspring.

Eur J Paediatr Neurol 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Chorioamnionitis is a common and potentially devastating complication of pregnancy associated with maternal and perinatal adverse outcomes.

Objective: To evaluate a possible association between maternal chorioamnionitis and long-term pediatric neurological morbidity.

Study Design: A population-based retrospective cohort analysis was performed comparing the risk of long-term neurological morbidity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183045
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http://dx.doi.org/10.1016/j.ejpn.2019.03.005DOI Listing
March 2019
1 Read

Previous glucocorticoid treatment in childhood and adolescence is associated with long-term differences in subcortical grey matter volume and microstructure.

Neuroimage Clin 2019 Apr 11;23:101825. Epub 2019 Apr 11.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark. Electronic address:

Background: Glucocorticoids are widely used in the treatment of several pediatric diseases with undisputed disease-related benefits. Perinatal exposure to high levels of glucocorticoids can have long-term adverse cerebral effects. In adults, glucocorticoid treatment has been associated with smaller volumes of subcortical grey matter structures. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101825DOI Listing

Obstetric complications in bipolar disorder: The role of mental health disorders in the risk of caesarean section.

J Affect Disord 2019 Apr 8;252:458-463. Epub 2019 Apr 8.

Perinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clinic, IDIBAPS, Barcelona, Catalonia, Spain; Vulnerability, Psychopathology and Gender research group, Generalitat de Catalunya, Catalonia, Spain.

Background: Women with Bipolar Disorder (BD) during pregnancy present a negative impact on them and their babies' health. Caesarean Section (C-Section) is an intervention to reduce complications associated with childbirth, but it also has risks, including maternal infections, anaesthetic and psychological complications. There are few studies that analyse the C-Section rates in women with BD compared to the general population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183226
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http://dx.doi.org/10.1016/j.jad.2019.04.017DOI Listing
April 2019
2 Reads

Perinatal outcomes including long-term neuropsychiatric hospitalizations of offspring conceived during intrauterine contraceptive device use.

Contraception 2019 Apr 17. Epub 2019 Apr 17.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Objective: To investigate short-term adverse perinatal outcomes and long-term neuropsychiatric hospitalizations through 18years of age in offspring conceived during copper intrauterine device (IUD) use.

Study Design: We conducted a population-based cohort study comparing the pregnancy outcomes after 22weeks of women who conceived with a copper IUD that was removed, women with a retained IUD and pregnancies without an IUD. Deliveries occurred between the years 1991-2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00107824193014
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http://dx.doi.org/10.1016/j.contraception.2019.04.005DOI Listing
April 2019
1 Read

Low-dose aspirin reduces hypoxia-induced sFlt1 release via the JNK/AP-1 pathway in human trophoblast and endothelial cells.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Pre-eclampsia (PE) is a serious hypertensive disorder of pregnancy that remains a leading cause of perinatal and maternal morbidity and mortality worldwide. Placental ischemia/hypoxia and the secretion of soluble fms-like tyrosine kinase 1 (sFlt1) into maternal circulation are involved in the pathogenesis of PE. Although low-dose aspirin (LDA) has beneficial effects on the prevention of PE, the exact mechanisms of action of LDA, particularly on placental dysfunction, and sFlt1 release, have not been well investigated. Read More

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http://dx.doi.org/10.1002/jcp.28533DOI Listing

Postvaccination Febrile Seizure Severity and Outcome.

Pediatrics 2019 Apr 19. Epub 2019 Apr 19.

National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Sydney, Australia.

Background: Febrile seizures (FSs) are a common pediatric condition caused by a sudden rise in temperature, affecting 3% to 5% of children aged ≤6 years. Although vaccination can cause FSs, little is known on whether FSs occurring in the time soon after vaccination (vaccine-proximate febrile seizures [VP-FSs] differ clinically from non-vaccine-proximate febrile seizures [NVP-FSs]). We compared the clinical profile and outcomes of VP-FS to NVP-FS. Read More

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http://dx.doi.org/10.1542/peds.2018-2120DOI Listing
April 2019
6 Reads

Impact of Episiotomy During Operative Vaginal Delivery on Obstetrical Anal Sphincter Injuries.

J Obstet Gynaecol Can 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, University of Alberta, Lois Hole Hospital for Women, Edmonton, AB. Electronic address:

Objective: The purpose of this study was to describe associations between episiotomy at the time of forceps or vacuum-assisted delivery and obstetrical anal sphincter injuries (OASIS).

Methods: This population-based retrospective cohort study used delivery information from a provincial perinatal clinical database. Full-term, singleton, in-hospital, operative vaginal deliveries of vertex-presenting infants from April 1, 2006 to March 31, 2016 were identified. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.02.016DOI Listing

Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study.

Brain Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Neuroradiology, Istanbul Faculty of Medicine, Istanbul, Turkey.

Purpose: To identify the frequency of epilepsy and whether the association of epilepsy with clinical and neuroimaging findings in children with presumed perinatal arterial ischemic stroke (PPAIS).

Methods: We performed a retrospective analysis of 37 children with PPAIS followed-up at a tertiary referral center between January 1, 2000, and October 31, 2016. Clinical data including demographic features, age at onset of symptoms and seizures, initial clinical presentation, epilepsy features, used antiepileptic drugs, and thrombophilia screening results were abstracted from medical records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604193009
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http://dx.doi.org/10.1016/j.braindev.2019.04.004DOI Listing
April 2019
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Use of ultrasound and mHealth to improve perinatal outcomes in low and middle income countries.

Semin Perinatol 2019 Mar 16. Epub 2019 Mar 16.

Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.

The explosion of mobile health and portable obstetric ultrasound interventions in low- and middle-income countries (LMIC) reflects the optimism that technology can help reduce persistently high rates of maternal and neonatal mortality and morbidity in these settings. While these technology-driven interventions have had success in improving aspects of antenatal and perinatal care, they have not clearly demonstrated reductions in mortality. The expanding synergy between mobile health (mHealth) and ultrasound technology shows promise to enhance care, but it will likely take combining these technological advances with system-wide approaches that also address referral patterns and infrastructure barriers to improve outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193004
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http://dx.doi.org/10.1053/j.semperi.2019.03.016DOI Listing
March 2019
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Health of adults aged 22 to 35 years conceived by assisted reproductive technology.

Fertil Steril 2019 Apr 9. Epub 2019 Apr 9.

Hudson Institute of Medical Research, Clayton, Victoria, Australia; Monash IVF Group Pty Ltd, Richmond, Victoria, Australia; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

Objective: To determine the health outcomes for adults aged 22-35 years old who were conceived via assisted reproduction technology (ART) compared with adults of the same age conceived without use of ART.

Design: Cohort study.

Setting: Not applicable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282193024
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http://dx.doi.org/10.1016/j.fertnstert.2019.03.001DOI Listing
April 2019
1 Read

Kurt Benirschke, MD (1924-2018): Pioneer in Perinatal and Placental Pathology.

Pediatr Dev Pathol 2019 Apr 19:1093526619843723. Epub 2019 Apr 19.

1 Surgical Pathology, Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, Weill Cornell Medicine, New York, New York.

Kurt Benirschke, noted pathologist and animal conservationist, passed away on September 10, 2018 at the age of 94. Kurt Benirschke is a legendary figure in perinatal pathology and was likely the first pathologist to have a genuine interest in the placenta. With Shirley Driscoll, he wrote the first textbook on placental pathology-The Pathology of the Human Placenta published in 1967. Read More

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http://dx.doi.org/10.1177/1093526619843723DOI Listing
April 2019
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SMFM Special Statement: State of the Science on Multifetal Gestations: Unique Considerations and Importance.

Am J Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States.

We sought to review the state of the science for research on multiple gestations. A literature search was performed using PubMed to quantify the representation of multiple gestations for a sample period (2012-2016) limited to Phase III and IV randomized controlled trials and written in English addressing at least one of four major pregnancy complications for illustration: fetal growth restriction or small-for-gestational-age fetus, gestational diabetes, preeclampsia, and preterm delivery. Of the 226 studies included in the analysis, multiple pregnancies were most represented in studies of preterm delivery: 17% of trials recruited both singleton and multiple pregnancies, and another 18% of trials recruited only multiple pregnancies. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.013DOI Listing

Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats.

PLoS One 2019 19;14(4):e0215611. Epub 2019 Apr 19.

Department of Physiology & Pharmacology, The University of Western Ontario, London, Ontario, Canada.

Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics and the surfactant system during the neonatal period. To test this hypothesis a model of FGR was utilized in which pregnant rat dams were fed a low protein diet during both the gestation and lactation period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215611PLOS
April 2019
3 Reads

The best perinatal depression screening: Is self-administered PHQ2 more feasible than a nurse-administered one?

Perspect Psychiatr Care 2019 Apr 18. Epub 2019 Apr 18.

Department of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.

Purpose: To assess perinatal depression screening via self-administered PHQ2 (SAP) vs nurse-administered PHQ2 (NAP).

Design And Methods: NAP screening was performed for 3 months, followed by SAP. Data were gathered from visits at 24 to 28 weeks gestation. Read More

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http://dx.doi.org/10.1111/ppc.12383DOI Listing

Perinatal Exposure Is Associated With Increased Risk of Late Onset Sepsis and Imbalanced Inflammation in Preterm Infants and May Add to Lung Injury.

Front Cell Infect Microbiol 2019 2;9:68. Epub 2019 Apr 2.

University Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.

Controversy remains concerning the impact of on preterm neonatal morbidity. Prospective single-center study in very low birth weight infants <30 weeks' gestation. Cord blood and initial nasopharyngeal swabs were screened for and using culture technique and polymerase chain reaction. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00068
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http://dx.doi.org/10.3389/fcimb.2019.00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454044PMC
April 2019
1 Read

CXCR2 Blockade Mitigates Neural Cell Injury Following Preclinical Chorioamnionitis.

Front Physiol 2019 2;10:324. Epub 2019 Apr 2.

Department of Pediatrics, School of Medicine, The University of New Mexico, Albuquerque, NM, United States.

Minimizing central nervous system (CNS) injury from preterm birth depends upon identification of the critical pathways that underlie essential neurodevelopmental and CNS pathophysiology. While chorioamnionitis (CHORIO), is a leading cause of preterm birth, the precise mechanism linking prenatal brain injury and long-term CNS injury is unknown. The chemokine (C-X-C motif) ligand 1 (CXCL1) and its cognate receptor, CXCR2, are implicated in a variety of uterine and neuropathologies, however, their role in CNS injury associated with preterm birth is poorly defined. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00324
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http://dx.doi.org/10.3389/fphys.2019.00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454349PMC
April 2019
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Antenatal Hypoxia and Programming of Glucocorticoid Receptor Expression in the Adult Rat Heart.

Front Physiol 2019 2;10:323. Epub 2019 Apr 2.

Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Glucocorticoid receptor (GR) signaling is critical for development and function of the heart. Our previous study demonstrated that gestational hypoxia induced epigenetic repression of the GR gene in the developing heart. The present study aims to determine that the alterations of promoter methylation level and epigenetic repression of the GR gene in the developing heart in response to maternal hypoxia is sustained in adult offspring and potential gender differences in the programming of GR gene. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00323
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http://dx.doi.org/10.3389/fphys.2019.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454194PMC
April 2019
2 Reads

Influence of Different Methods of Intrapartum Analgesia on the Progress of Labour and on Perinatal Outcome.

Geburtshilfe Frauenheilkd 2019 Apr 1;79(4):389-395. Epub 2019 Feb 1.

Sektion für Geburtshilfe und Perinatalmedizin, Klinikum rechts der Isar, Technische Universität München, München, Germany.

Various methods of intrapartum analgesia are available these days. Pethidine, meptazinol and epidural analgesia are among the most commonly used techniques. A relatively new one is patient-controlled intravenous analgesia with remifentanil, although the experiences published so far in Germany are limited. Read More

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http://dx.doi.org/10.1055/a-0774-8617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461463PMC

The clinical effect of classical music and lullaby on term babies in neonatal intensive care unit: A randomised controlled trial.

J Pak Med Assoc 2019 Apr;69(4):459-463

Nursing Department, Faculty of Health Sciences, Ankara University, TURKEY.

Objective: To investigate the effect of music during routine nursing care on full-term newborns physiological measurements, hospital stay and stress symptoms.

Methods: The randomised controlled trial was conducted at the Level II neonatal intensive care unit of a state hospital in Turkey from November 2014 to August 2015, and comprised full-term newborns. Three groups were formed by simple randomisation according to babies' Score for Neonatal Acute Physiology with Perinatal Extension-II; classical music, lullaby, and a control group. Read More

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April 2019
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Prenatal Treatment of X-Linked Hypohidrotic Ectodermal Dysplasia using Recombinant Ectodysplasin in a Canine Model.

J Pharmacol Exp Ther 2019 Apr 18. Epub 2019 Apr 18.

University of Pennsylvania;

X-linked hypohidrotic ectodermal dysplasia (XLHED) is caused by defects in the EDA gene that inactivate the function of ectodysplasin A (EDA1). This leads to abnormal development of eccrine glands, hair follicles and teeth, and to frequent respiratory infections. Previous studies in the naturally occurring dog model demonstrated partial prevention of the XLHED phenotype by postnatal administration of recombinant ectodysplasin (Fc:EDA1; EDI200). Read More

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http://dx.doi.org/10.1124/jpet.118.256040DOI Listing
April 2019
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Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.

Brain Dev 2019 Apr 15. Epub 2019 Apr 15.

Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.

Hypophosphatasia (HPP) is a rare disorder caused by low serum tissue non-specific alkaline phosphatase (ALP) activity due to hypomorphic mutations in the ALPL gene. HPP is characterized by defective bone mineralization. It frequently accompanies pyridoxine-responsive seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183059
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http://dx.doi.org/10.1016/j.braindev.2019.03.015DOI Listing
April 2019
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Nationwide survey of neonatal transportation practices in Italy.

Ital J Pediatr 2019 Apr 18;45(1):51. Epub 2019 Apr 18.

Neonatal Intensive Care Unit, Neonatal Emergency Transport Service, Department Mother&Child, IRCCS Istituto Giannina Gaslini, Largo G. Gaslini, 5, 16147, Genoa, Italy.

Background: Despite regionalization of perinatal care provides for the "in utero" transfer of high-risk pregnancies, there will always be a number of neonates who undergo acute inter-facility transport. The presence of a well-organized Neonatal Emergency Transport Service (NETS) can prevent and reduce risks of transportation, especially for very preterm infants, and is therefore mandatory for any program of regionalization of perinatal care. Italian National Health System is highly decentralized and Regions are autonomous to structure, plan and delivery their regional health services. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0640-zDOI Listing
April 2019
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Glucose screening within six months postpartum among Chinese mothers with a history of gestational diabetes mellitus: a prospective cohort study.

BMC Pregnancy Childbirth 2019 Apr 18;19(1):134. Epub 2019 Apr 18.

Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.

Background: Gestational diabetes mellitus (GDM) is a risk factor for diabetes mellitus. The 75-g, 2-h oral glucose tolerance test is recommended for mothers with a history of GDM to screen for diabetes in the postnatal period. The aim of this study was to investigate the rate of glucose screening within 6 months postpartum among Chinese mothers with a history of GDM, and to identify its predictors. Read More

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http://dx.doi.org/10.1186/s12884-019-2276-9DOI Listing

Analysis of preventability of malignancy related maternal death from the nationwide registration syste19m of maternal deaths in Japan.

J Matern Fetal Neonatal Med 2019 Apr 18:1-191. Epub 2019 Apr 18.

b Department of Obstetrics and Gynecology , Mie University School of Medicine , Mie , Japan.

Objective: We reviewed malignancy related maternal deaths in Japan to ascertain if there were avoidable factors.

Methods: Malignancy related maternal death in Japan reported to the Maternal Death Exploratory Committee, from 2010 to 2016 inclusive.

Results: There were 12 cases of maternal death caused by malignancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609930DOI Listing

Pushing the limits: perinatal outcomes beyond prolonged second stage.

J Matern Fetal Neonatal Med 2019 Apr 18:1-211. Epub 2019 Apr 18.

d Alexandria Health , Boston , USA.

Objective: To evaluate whether extremely prolonged second stage of labor in nulliparous women affects mode of delivery and perinatal outcomes.

Methods: We performed a retrospective cohort study of nulliparous women with singleton gestations and cephalic presentation who reached 10 cm of cervical dilation at gestational age 36 0/7-41 6/7. Women were stratified by epidural status. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609927DOI Listing

Perinatal breastfeeding interventions including fathers/partners: A systematic review of the literature.

Midwifery 2019 Apr 3;75:41-51. Epub 2019 Apr 3.

St. Michael's Hospital, University of Toronto, Canada.

Objective: Support from fathers is consistently associated with improved breastfeeding duration and exclusivity rates. Additionally, there is growing evidence that fathers want to be included in breastfeeding interventions provided by health care professionals. The objective of this review was to determine the effect of partner-inclusive educational and psychosocial interventions on breastfeeding initiation, duration, and exclusivity. Read More

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http://dx.doi.org/10.1016/j.midw.2019.04.001DOI Listing

Mechanisms underlying a critical period of respiratory development in the rat.

Respir Physiol Neurobiol 2019 Apr 15. Epub 2019 Apr 15.

Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, New Mexico 87108, USA.

Twenty-five years ago, Filiano and Kinney (1994) proposed that a critical period of postnatal development constitutes one of the three risk factors for sudden infant death syndrome (SIDS). The underlying mechanism was poorly understood. In the last 17 years, much has been uncovered on this period in the rat. Read More

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http://dx.doi.org/10.1016/j.resp.2019.04.006DOI Listing
April 2019
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Association of periodontal disease with depression and adverse birth outcomes: Results from the Perinatal database; Finger Lakes region, New York State.

PLoS One 2019 18;14(4):e0215440. Epub 2019 Apr 18.

Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, United States of America.

Preterm and low birth weight infants are at greater risk for mortality and a variety of health and developmental problems. Data from the Finger Lakes Perinatal Data System database on 316,956 deliveries occurring between 2004-2014 and pregnancy outcomes were analyzed to assess the association of periodontal (gum) disease with depression, other maternal factors and adverse birth outcomes. Adjusted effects of periodontal disease and depression on adverse birth outcomes were estimated using multiple logistic regression models and path analysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215440PLOS
April 2019
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Disordered eating and the perinatal period: A systematic review and best evidence synthesis of mental health and psychosocial correlates.

Eur Eat Disord Rev 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychological Sciences, Swinburne University, Hawthorn, Melbourne, Australia.

Objective: This paper systematically reviews the literature to date on the relationship between disordered eating and mental health, psychological and social factors during pregnancy and the post-partum period, as well as the direction of associations.

Methods: Peer reviewed articles were sourced from seven databases: PsycINFO, CINAHL, Psychology and Behavioural Sciences Collection, Academic Search Complete, Scopus (MEDLINE), Web of Science, and Proquest. A quality review and best evidence synthesis was conducted. Read More

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http://dx.doi.org/10.1002/erv.2675DOI Listing

Female Sex Workers' Experiences Selling Sex during Pregnancy and Post-Delivery in South Africa.

Stud Fam Plann 2019 Apr 17. Epub 2019 Apr 17.

Nearly 75 percent of female sex workers (FSWs) in Port Elizabeth, South Africa are mothers, many of whom engage in sex work during pregnancy or after delivery. We conducted in-depth interviews with 22 postpartum and 8 pregnant FSWs in Port Elizabeth. Interview guides were used to probe women's experiences, challenges, and concerns about selling sex during pregnancy and post-delivery in a high-HIV-prevalence context. Read More

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http://dx.doi.org/10.1111/sifp.12090DOI Listing