77,821 results match your criteria Journal of Perinatal & Neonatal Nursing[Journal]


Postpartum post-traumatic stress disorder: Associated perinatal factors and quality of life.

J Affect Disord 2019 Feb 10;249:143-150. Epub 2019 Feb 10.

Department of Health Sciencies, University of Jaen, Jaen, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Madrid, Spain.

Background: The relationship between obstetric variables and postpartum post-traumatic stress disorder (PTSD), and its influence on quality of life (QoL), have scarcely been studied.

Objective: Determine the prevalence of PTSD at postpartum weeks 4 and 6, and its relation with perinatal variables and quality of life METHOD: A cross-sectional study with 2990 Spanish puerperal women in Spain. Data were collected on socio-demographic and obstetric variables, and on newborns. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.042DOI Listing
February 2019

Diagnosis of Fetal Multicystic Dysplastic Kidney in the First Trimester of Pregnancy by 2-D and 3-D Ultrasonography.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Perinatal Service, Monash Medical Centre, Clayton, Victoria, Australia; Mercy Hospital for Women, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1016/j.jogc.2018.05.028DOI Listing
February 2019

Diagnostic d'une dysplasie rénale multikystique fœtale au premier trimestre de grossesse par échographies 2D et 3D.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Perinatal Service, Monash Medical Centre, Clayton, Victoria, Australia; Mercy Hospital for Women, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1016/j.jogc.2018.08.007DOI Listing
February 2019

Design errors in vital sign charts used in consultant-led maternity units in the United Kingdom.

Int J Obstet Anesth 2019 Jan 8. Epub 2019 Jan 8.

Centre for Midwifery, Maternal & Perinatal Health, Bournemouth University, Bournemouth, UK.

Background: Paper-based charts remain the principal means of documenting the vital signs of hospitalised pregnant and postnatal women. However, poor chart design may contribute to both incorrect charting of data and clinical responses. We decided to identify design faults that might have an adverse clinical impact. Read More

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http://dx.doi.org/10.1016/j.ijoa.2019.01.001DOI Listing
January 2019

Primary and secondary prevention of preterm birth: a review of systematic reviews and ongoing randomized controlled trials.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 25. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, Dalhousie University, Halifax Nova Scotia, Canada.

Background: Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality. Interventions aimed at preventing PTB can be classified as primary, secondary, or tertiary prevention.

Objective: To conduct a review of systematic reviews on the effectiveness and safety of primary and secondary preterm birth prevention interventions. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.12.022DOI Listing
January 2019

Influence of Growth Factors on the Development of Necrotizing Enterocolitis.

Clin Perinatol 2019 Mar 20;46(1):51-64. Epub 2018 Dec 20.

Department of Pediatric Surgery, Nationwide Children's Hospital, FB6135, 700 Children's Drive, Columbus, OH 43205, USA. Electronic address:

Growth factors have important roles in gastrointestinal tract development, maintenance, and response to injury. Various experiments have been used to demonstrate growth factor influence in multiple disease processes. These studies demonstrated enhancement of mucosal proliferation, intestinal motility, immune modulation, and many other beneficial effects. Read More

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http://dx.doi.org/10.1016/j.clp.2018.10.005DOI Listing

Modifiable Risk Factors in Necrotizing Enterocolitis.

Authors:
C Michael Cotten

Clin Perinatol 2019 Mar 21;46(1):129-143. Epub 2018 Dec 21.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Duke University School of Medicine, Box 2739 DUMC, Durham, NC 27710, USA. Electronic address:

Multicenter groups have reported reductions in the incidence of necrotizing enterocolitis (NEC) among preterm infants over the past 2 decades. These large-scale prevalence studies have coincided with reports from multicenter consortia and single centers of modifications in practice using quality-improvement techniques aimed at either reducing NEC risk specifically or reducing risk of mortality and multiple morbidities associated with extreme prematurity. The modifications in practice have been based on mechanistic studies, epidemiologic association data, and clinical trials. Read More

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http://dx.doi.org/10.1016/j.clp.2018.10.007DOI Listing

Epidemiology of Necrotizing Enterocolitis: New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia.

Clin Perinatol 2019 Mar 12;46(1):101-117. Epub 2018 Dec 12.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, 2015 Uppergate Drive Northeast, 3rd Floor, Atlanta, GA 30322, USA. Electronic address:

This article summarizes available evidence on the relationship between red blood cell transfusion and anemia, and necrotizing enterocolitis (NEC). We review recent studies that highlight the uncertainty of the effect of red blood cell transfusion on NEC and the potential role of anemia. We also discuss potential pathophysiologic effects of both red blood cell transfusion and anemia and highlight strategies to prevent anemia and red blood cell transfusion. Read More

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http://dx.doi.org/10.1016/j.clp.2018.09.006DOI Listing

Surveillance of pregnant women with potential exposure to Zika virus following travel.

G Chir 2019 Jan-Feb;40(1):58-65

Aim: To describe the experience of a single fetal medicine unit in evaluating pregnant women with potential exposure to Zika virus (ZIKV) following travel.

Method: Between February 2016 and June 2017, a multidisciplinary team evaluated pregnant women by developing a local pathway based on Public Health England guidance. All pregnant women were offered serial fetal ultrasound scans (USS). Read More

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February 2019

Natural history of ventriculomegaly in adults: a cluster analysis.

J Neurosurg 2019 Feb 8:1-8. Epub 2019 Feb 8.

OBJECTIVEChronic ventriculomegaly in the absence of raised intracranial pressure (ICP) is a known entity in adult hydrocephalus practice. The natural history and indication for treatment is, however, poorly defined. A highly heterogeneous group, some adults with ventriculomegaly are asymptomatic, while others have life-threatening deteriorations. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18119DOI Listing
February 2019

Mobile obstetric and neonatal simulation based skills training in India.

Midwifery 2019 Feb 7;72:14-22. Epub 2019 Feb 7.

Department of Paediatrics, Monash University, Melbourne, Australia.

Background: The developing world has a significantly high risk of women and babies dying during childbirth. Interprofessional simulation training has improved birth practices and outcomes by impacting clinical and non-technical skills like communication, teamwork, leadership and effective use of resources. While these programs have become a training requirement in many high-income countries, they have not been widely introduced in the low-income, low-resource settings. Read More

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http://dx.doi.org/10.1016/j.midw.2019.02.006DOI Listing
February 2019

Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Maternal Fetal Medicine Unit. Department of Obstetrics. Hospital Universitari Vall d'Hebron. Ps. Vall d'Hebron 119-129, 08035 Barcelona. Universitat Autònoma de Barcelona.

Objectives: to describe pregnancy outcomes after Zika virus (ZIKV) infection in a non-endemic region.

Methods: according to the Spanish protocol issued after the ZIKV outbreak in Brazil in 2015, all pregnant women who had travelled to high-burden countries were screened for ZIKV. Serological and molecular tests were used to identify ZIKV-infected pregnant women. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.008DOI Listing
February 2019

Cumulative multiple early life hits- a potent threat leading to neurological disorders.

Brain Res Bull 2019 Feb 13. Epub 2019 Feb 13.

School of Studies in Neuroscience, Jiwaji University, Gwalior, India; School of Studies in Zoology, Jiwaji University, Gwalior, India. Electronic address:

Early life Stress is a worldwide concern linked with development of later life neurological disorder. Early developmental age is sensitive to many prominent environmental insults like malnourishment, immune inflammation, abuse, maternal separation, alcohol and drugs. Hence, an individual during an early age encounters more than one simultaneous stressor that leads to impairment of cognitive and behavioral abilities, a symptom common to most of the neurological disorders. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.005DOI Listing
February 2019

Methylphenidate administration reverts attentional inflexibility in adolescent rats submitted to a model of neonatal hypoxia-ischemia: Predictive validity for ADHD study.

Exp Neurol 2019 Feb 13. Epub 2019 Feb 13.

Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Ciências Morfológicas, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Perinatal complications such as birth asphyxia were associated with a higher risk for Attention-Deficit/Hyperactivity Disorder (ADHD) in humans. Data from a rat model of neonatal hypoxia-ischemia (HI) have revealed inattention, impulsive behavior and dopamine (DA) disturbances in the prefrontal cortex (PFC), confirming the face validity and construct validity for ADHD study. However, the predictive validity (similar therapeutic efficacy of the pharmacological treatment available in the clinic) should be considered. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.02.004DOI Listing
February 2019

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries.

Arch Gynecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: To estimate the impact of increasing pre-pregnancy Body Mass Index (BMI) on the risk of adverse maternal and perinatal outcomes, in patients who delivered in an Italian tertiary care Obstetric department.

Methods: Data, related to women who delivered at Sant'Anna Hospital, Turin, between 2011 and 2015, were collected retrospectively from the hospital database. According to BMI, women were considered as normal weight, overweight, and class 1, 2 and 3 obese (WHO criteria). Read More

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http://dx.doi.org/10.1007/s00404-019-05093-0DOI Listing
February 2019
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Is early caffeine therapy safe and effective for ventilated preterm infants?

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/s41372-019-0336-7DOI Listing
February 2019

Oocyte-derived E-cadherin acts as a multiple functional factor maintaining the primordial follicle pool in mice.

Cell Death Dis 2019 Feb 15;10(3):160. Epub 2019 Feb 15.

State Key Laboratory of Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing, 100193, China.

In mammals, female fecundity is determined by the size of the primordial follicle (PF) pool, which is established during the perinatal period. As a non-renewable resource, the preservation of dormant PFs is crucial for sustaining female reproduction throughout life. Although studies have revealed that several oocyte-derived functional genes and pathways, such as newborn ovary homeobox (NOBOX) and 3-phosphoinositide-dependent protein kinase-1, participate in maintaining the PF pool, our understanding of the underlying molecular mechanisms is still incomplete. Read More

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http://www.nature.com/articles/s41419-018-1208-3
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http://dx.doi.org/10.1038/s41419-018-1208-3DOI Listing
February 2019
1 Read

Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Division of Nutritional Sciences, Cornell University, Ithaca, NY.

Background: It has been proposed that the fetus prioritizes iron for hemoglobin production over delivery to tissues. However, few studies have evaluated the interrelations between hemoglobin and multiple iron status biomarkers in umbilical cord blood. A full understanding is needed of how these parameters influence each other within cord blood to fully interpret iron and hematologic status at birth. Read More

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http://dx.doi.org/10.1093/jn/nxy286DOI Listing
February 2019

Reproductive health outcomes in women with psoriatic arthritis.

Ann Rheum Dis 2019 Feb 15. Epub 2019 Feb 15.

EULAR Centre For Arthritis And Rheumatic Diseases, Dublin Academic Medical Centre, Dublin, Ireland.

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http://dx.doi.org/10.1136/annrheumdis-2018-214790DOI Listing
February 2019

CdSe/ZnS Quantum Dots Impaired the First Two Generations of Placenta Growth in an Animal Model, Based on the Shh Signaling Pathway.

Nanomaterials (Basel) 2019 Feb 14;9(2). Epub 2019 Feb 14.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.

The toxicity, especially the transgenerational toxicity of quantum dots (QDs) in vivo, is still scarcely understood in spite of great promising applications of QDs in biomedicine. In this study, the maternal status, pregnancy outcome, and fetus development of parental generation (P0) to offspring in three generations (F3) were investigated after Kunming mice perinatal (GD 13-PND 5) exposure to Cd containing QDs (CdSe/ZnS QDs) and CdCl₂. The results show CdSe/ZnS QDs induced placenta injuries in P0 and diminished placenta diameters in F1 and F2. Read More

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http://dx.doi.org/10.3390/nano9020257DOI Listing
February 2019

The process of change in psychotherapy with a pregnant patient following perinatal losses: An analysis of a case study.

J Clin Psychol 2019 Feb 15. Epub 2019 Feb 15.

The Department of Psychology, University of Haifa, Haifa, Israel.

Aim: Despite research suggesting increased anxiety and depressive symptoms after a perinatal loss and during future pregnancies, little knowledge exists to guide clinicians treating pregnant women after perinatal loss. This case study explores processes that facilitated therapeutic change for a pregnant patient with major depressive disorder (MDD) and posttraumatic stress disorder after perinatal losses.

Method: The study integrated quantitative and narrative analyses in a single case derived from the pilot phase of a randomized controlled trial on supportive-expressive therapy for MDD. Read More

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http://dx.doi.org/10.1002/jclp.22763DOI Listing
February 2019

Psychotic-Like Experiences in Offspring of Parents With Bipolar Disorder and Community Controls: A Longitudinal Study.

J Am Acad Child Adolesc Psychiatry 2018 Nov 2. Epub 2018 Nov 2.

University of Pittsburgh, PA.

Objective: To compare the prevalence and risk factors associated with Psychotic-Like-Experiences (PLE) in offspring of parents with bipolar disorder (BP) and offspring of community control parents.

Method: Delusional and hallucinatory subclinical psychotic experiences were evaluated at intake and longitudinally in a cohort study of 390 offspring of BP parents and 247 offspring of control parents aged 6-18 years old. The sample was followed up every 2. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.09.440DOI Listing
November 2018

Mitigation of Participant Loss to Follow-Up Using Facebook: All Our Families Longitudinal Pregnancy Cohort.

J Med Internet Res 2019 Feb 15;21(2):e10441. Epub 2019 Feb 15.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Background: Facebook, a popular social media site, allows users to communicate and exchange information. Social media sites can also be used as databases to search for individuals, including cohort participants. Retaining and tracking cohort participants are essential for the validity and generalizability of data in longitudinal research. Read More

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http://dx.doi.org/10.2196/10441DOI Listing
February 2019

High- versus low-intensity interventions for perinatal depression delivered by non-specialist primary maternal care providers in Nigeria: cluster randomised controlled trial (the EXPONATE trial).

Br J Psychiatry 2019 Feb 15:1-8. Epub 2019 Feb 15.

Associate Professor,Division of Social and Transcultural Psychiatry,McGill University; andResearch Director,Department of Psychiatry,Jewish General Hospital,Canada.

Background: Contextually appropriate interventions delivered by primary maternal care providers (PMCPs) might be effective in reducing the treatment gap for perinatal depression.AimTo compare high-intensity treatment (HIT) with low-intensity treatment (LIT) for perinatal depression.

Method: Cluster randomised clinical trial, conducted in Ibadan, Nigeria between 18 June 2013 and 11 December 2015 in 29 maternal care clinics allocated by computed-generated random sequence (15 HIT; 14 LIT). Read More

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http://dx.doi.org/10.1192/bjp.2019.4DOI Listing
February 2019

Dental Team's Role in Maternal and Child Oral Health During and After Pregnancy.

Compend Contin Educ Dent 2019 Feb;40(2):90-96; quiz 97

Associate Professor, Director, Predoctoral Pediatric Dentistry, University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama.

For a mother-to-be, pregnancy presents an opportunity to improve not only her health and well being but also that of the immediate family, particularly the newborn infant. The National Consensus Statement of the Oral Health Care During Pregnancy Expert Group together with both governmental and non-governmental guidelines indicate that dental care is both safe and effective during pregnancy. These statements and guidelines may not be widely understood across all healthcare providers that form the perinatal care team, and confusion seems to exist among the general public regarding the safety of and necessity for dental care during pregnancy. Read More

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February 2019

Planned home births in the Czech Republic, 2018.

Ceska Gynekol 2018 ;83(3):204-211

Study Aim: A summary of the current situation regarding issues of planned home births in the Czech Republic.

Type Of Study: Review and summarization. Affiliations: Department of Obstetrics and Gynecology of the Liberec regional hospital, and the Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital in Prague. Read More

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January 2018

The Significance of Yolk Sac Number in Monoamniotic Twins.

Fetal Diagn Ther 2019 Feb 14:1-7. Epub 2019 Feb 14.

The University of Melbourne, Department of Obstetrics and Gynaecology, The Royal Women's Hospital, Parkville, Victoria, Australia.

Background: Detection of a single yolk sac on early first trimester ultrasound was previously thought to be a reliable diagnostic feature of monochorionic monoamniotic (MCMA) twin pregnancies.

Objectives: To determine the frequency of two yolk sacs in MCMA twin pregnancies and the association of yolk sac number with pregnancy outcomes.

Methods: A retrospective cohort analysis of MCMA twins managed at a tertiary obstetric centre from January 2003 until February 2017. Read More

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http://dx.doi.org/10.1159/000496204DOI Listing
February 2019

Association between birth attendant type and delivery site and perinatal outcomes.

Int J Gynaecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

University of Alabama at Birmingham, Birmingham, Alabama.

Objective: To test the hypothesis that modified perinatal mortality, early neonatal mortality, and other measures of perinatal mortality are lower with facility births than with home births among deliveries conducted by traditional birth attendants (TBAs) or nurse-midwives.

Method: This population-based observational study used data collected prospectively for home and facility deliveries conducted by TBAs and nurse-midwives in 13 rural communities in Zambia between September 1, 2009, and December 31, 2015.

Results: We enrolled 48,956 pregnant women. Read More

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http://dx.doi.org/10.1002/ijgo.12786DOI Listing
February 2019

Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia.

PLoS One 2019 14;14(2):e0211910. Epub 2019 Feb 14.

Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands.

Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in this population are largely unknown. The objective of this study was to describe pharmacokinetics of morphine and its metabolites morphine-3-glucuronide and morphine-6-glucuronide in encephalopathic neonates treated with therapeutic hypothermia and to develop pharmacokinetics based dosing guidelines for this population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211910PLOS
February 2019

'Conceivably Neglected' - Are prescribers sufficiently aware of the risks of prescribing sodium valproate to women with mental illness?

Australas Psychiatry 2019 Feb 14:1039856219828175. Epub 2019 Feb 14.

Consultant Psychiatrist and staff specialist, Fellow Royal Australian and New Zealand College of Psychiatrists, Redcliffe-Caboolture Mental Health Service, Metro-North Mental Health Service, Brisbane, QLD, Australia.

Objectives:: To describe prescription of sodium valproate (SV) for bipolar mood disorder to potentially child-bearing women within one public mental health service and describe risks of fetal exposure, and safe prescribing practices among psychiatrists.

Methods:: A 24-month retrospective chart review with descriptive analysis; narrative review of literature and guidelines.

Results:: Review of 383 charts demonstrated prescription of valproate to 20% of 98 women aged 15-45, with little evidence of advice regarding risk and contraception. Read More

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http://dx.doi.org/10.1177/1039856219828175DOI Listing
February 2019

Aggravation of atrial arrhythmia by amiodarone during the perinatal period: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14466

Department of Cardiology, Wenzhou People's Hospital, Wenzhou Third Clinical Institute Affiliated with Wenzhou Medical University, Wenzhou, Zhejiang, China.

Rationale: Amiodarone, a broad-spectrum antiarrhythmic drug, is widely used for the clinical treatment of tachyarrhythmias because of its safety and efficacy.

Patient Concerns: A 30-year-old woman presented with known paroxysmal atrial tachycardia and severe preeclampsia. Two days before admission, she had given birth to twins. Read More

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http://dx.doi.org/10.1097/MD.0000000000014466DOI Listing
February 2019

The Other Parent: An Exploratory Survey of Providers' Engagement of Fathers in Pediatric Primary Care.

Clin Pediatr (Phila) 2019 Feb 14:9922819829032. Epub 2019 Feb 14.

1 Johns Hopkins University, Baltimore, MD, USA.

Although father engagement in pediatric care is associated with positive child health outcomes, pediatric primary care providers (PCPs) often focus on the mother-child dyad. This study sought to characterize pediatric PCPs' engagement of fathers in care. Pediatric PCPs affiliated with an academic health system were invited to complete an online survey. Read More

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http://dx.doi.org/10.1177/0009922819829032DOI Listing
February 2019

Anxiety, depression, dyadic adjustment, and attachment to the fetus in pregnancy: Actor-partner interdependence mediation analysis.

J Fam Psychol 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Psicologia.

Perinatal research has focused essentially on maternal outcomes leaving paternal outcomes unexplored. This cross-sectional study aimed to explore the intrapersonal and interpersonal effects of mothers' and fathers' anxiety and depressive symptoms on their own and their partners' antenatal attachment to the fetus. Additionally, it aimed to explore the mediating role of dyadic adjustment on these associations. Read More

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http://dx.doi.org/10.1037/fam0000513DOI Listing
February 2019
1 Read

Dispensing patterns of selective serotonin reuptake inhibitors before, during and after pregnancy: a 16-year population-based cohort study from the Netherlands.

Arch Womens Ment Health 2019 Feb 14. Epub 2019 Feb 14.

The Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.

Management of mental illness in the perinatal period with antidepressants is controversial, since evidence emerged on potential harmful effects to the unborn child. However, over time, the dispensing of antidepressants in the perinatal period has increased. We examined perinatal dispensing patterns over time and the role of a recently issued guideline in this regard. Read More

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http://dx.doi.org/10.1007/s00737-019-0951-5DOI Listing
February 2019

The effects of perinatal bisphenol A exposure on thyroid hormone homeostasis and glucose metabolism in the prefrontal cortex and hippocampus of rats.

Brain Behav 2019 Feb 13:e01225. Epub 2019 Feb 13.

Medical Institute of Developmental Disorders Research, Showa University, Tokyo, Japan.

Introduction: Bisphenol A (BPA) is an endocrine disruptor widely used to manufacture consumer goods. Although the thyroid hormone (TH) disrupting potential of BPA has been thought to be responsible for the neuropsychiatric deficits in the animals that experienced perinatal BPA exposure, the TH availability change at the level of specific brain structures has not been subject to systematic investigation.

Methods: In the present study the impacts of perinatal BPA exposure (0. Read More

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http://doi.wiley.com/10.1002/brb3.1225
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http://dx.doi.org/10.1002/brb3.1225DOI Listing
February 2019
2 Reads

Axonal water fraction as marker of white matter injury in primary-progressive multiple sclerosis: a longitudinal study.

Eur J Neurol 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Diffuse white matter (WM) injury is prominent in primary progressive multiple sclerosis (PP-MS) pathology and is a potential biomarker of disease progression. Diffusion Kurtosis Imaging (DKI) allows the quantification of non-Gaussian water diffusion, providing metrics with high WM pathological specificity.

Objective: To characterize the pathological changes occurring in the normal appearing white matter (NAWM) of patients with PP-MS at baseline and at 1-year follow-up and to assess their impact on disability and short-term disease progression. Read More

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http://dx.doi.org/10.1111/ene.13937DOI Listing
February 2019

Bestrophin-3 Expression in a Subpopulation of Astrocytes in the Neonatal Brain After Hypoxic-Ischemic Injury.

Front Physiol 2019 29;10:23. Epub 2019 Jan 29.

Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Bestrophin-3, a potential candidate for a calcium-activated chloride channel, recently was suggested to have cell-protective functions. We studied the expression and alternative splicing of bestrophin-3 in neonatal mouse brain and after hypoxic-ischemic (HI) injury and in human neonatal brain samples. HI brain injury was induced in 9-day old mice by unilateral permanent common carotid artery occlusion in combination with exposure to 10% oxygen for 50 min. Read More

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http://dx.doi.org/10.3389/fphys.2019.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362097PMC
January 2019

Polygenic risk for neuropsychiatric disease and vulnerability to abnormal deep grey matter development.

Sci Rep 2019 Feb 13;9(1):1976. Epub 2019 Feb 13.

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, United Kingdom.

Neuropsychiatric disease has polygenic determinants but is often precipitated by environmental pressures, including adverse perinatal events. However, the way in which genetic vulnerability and early-life adversity interact remains obscure. We hypothesised that the extreme environmental stress of prematurity would promote neuroanatomic abnormality in individuals genetically vulnerable to psychiatric disorders. Read More

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http://www.nature.com/articles/s41598-019-38957-1
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http://dx.doi.org/10.1038/s41598-019-38957-1DOI Listing
February 2019
1 Read

Evaluation of an improved tool for non-invasive prediction of neonatal respiratory morbidity based on fully automated fetal lung ultrasound analysis.

Sci Rep 2019 Feb 13;9(1):1950. Epub 2019 Feb 13.

BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu, University of Barcelona), Barcelona, Spain.

The objective of this study was to evaluate the performance of a new version of quantusFLM®, a software tool for prediction of neonatal respiratory morbidity (NRM) by ultrasound, which incorporates a fully automated fetal lung delineation based on Deep Learning techniques. A set of 790 fetal lung ultrasound images obtained at 24 + 0-38 + 6 weeks' gestation was evaluated. Perinatal outcomes and the occurrence of NRM were recorded. Read More

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http://www.nature.com/articles/s41598-019-38576-w
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http://dx.doi.org/10.1038/s41598-019-38576-wDOI Listing
February 2019
2 Reads

Comparison of pregnancy outcome between Immigrant women in couples with same ethnicity to mixed ethnicity couples.

J Matern Fetal Neonatal Med 2019 Feb 13:1-121. Epub 2019 Feb 13.

a Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine , Lis Maternity and Women's Hospital , Tel Aviv University , Tel Aviv , Israel.

Aim: To compare pregnancy outcome of immigrant women who became pregnant to a same ethnicity partner versus a partner from a different ethnicity.

Methods: A retrospective cohort study on all singleton pregnancies of immigrant women who delivered between the years 2011-2015 in a single tertiary University affiliated Hospital. Demographic and obstetrical data were collected. Read More

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http://dx.doi.org/10.1080/14767058.2019.1582634DOI Listing
February 2019
1 Read

Association of vitamin D receptor gene FokI and TaqI polymorphisms and risk of RDS.

J Matern Fetal Neonatal Med 2019 Feb 13:1-201. Epub 2019 Feb 13.

a ,of Neonatology Dr Sami Ulus Maternity and Children's Training and Research Hospital , Ankara , Turkey.

Background: Vitamin D and its receptor (VDR) have important roles in perinatal lung development. The objective of this study was to investigate the possible association between VDR FokI and TaqI polymorphism and development of respiratory distress syndrome (RDS) in preterm infants.

Method: A total of 173 premature infants < 34 weeks: 82 with RDS and 91 without RDS were enrolled. Read More

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http://dx.doi.org/10.1080/14767058.2019.1582629DOI Listing
February 2019

Third trimester uterine artery Doppler indices as predictors of preeclampsia and neonatal small for gestational age.

J Matern Fetal Neonatal Med 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Obstetrics and Gynecology , University of South Florida Morsani College of Medicine , Tampa , FL , USA.

Objective: To test the hypothesis that third-trimester uterine artery Doppler (UAD) predicts adverse pregnancy and neonatal outcomes in a high-risk population.

Study Design: This is a nested case control study of women with singleton gestations referred for a fetal growth ultrasound between 24 and 36 weeks. Third-trimester UAD was performed if estimated fetal weight (Hadlock's chart) was <20th percentile as these patients were considered high risk for poor pregnancy outcomes. Read More

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http://dx.doi.org/10.1080/14767058.2019.1575804DOI Listing
February 2019

Ependymal Cells Require Anks1a for Their Proper Development.

Mol Cells 2019 Feb 12. Epub 2019 Feb 12.

Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Korea.

Ependymal cells constitute the multi-ciliated epithelium, which lines the brain ventricular lumen. Although ependymal cells originate from radial glial cells in the perinatal rodent brain, the exact mechanisms underlying the full differentiation of ependymal cells are poorly understood. In this report, we present evidence that the Anks1a phosphotyrosine binding domain (PTB) adaptor is required for the proper development of ependymal cells in the rodent postnatal brain. Read More

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http://dx.doi.org/10.14348/molcells.2018.0432DOI Listing
February 2019

MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia.

Pediatr Res 2019 Feb 13. Epub 2019 Feb 13.

Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, and Lilling Family Neonatal Research Laboratory, Feinstein Institute for Medical Research, Manhasset, NY, USA.

Background: Congenital diaphragmatic hernia (CDH) is a complex birth anomaly with significant mortality and morbidity. Lung hypoplasia and persistent pulmonary hypertension (PPHN) limit survival in CDH. Macrophage migration inhibitory factor (MIF), a key regulator of innate immunity, is involved in hypoxia-induced vascular remodeling and PPHN. Read More

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http://www.nature.com/articles/s41390-019-0335-6
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http://dx.doi.org/10.1038/s41390-019-0335-6DOI Listing
February 2019
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Diffuse optical tomography for the detection of perinatal stroke at the cot side: a pilot study.

Pediatr Res 2019 Feb 13. Epub 2019 Feb 13.

neoLAB, The Evelyn Perinatal Imaging Centre, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Background: Perinatal stroke is a potentially debilitating injury, often under-diagnosed in the neonatal period. We conducted a pilot study investigating the role of the portable, non-invasive brain monitoring technique, diffuse optical tomography (DOT), as an early detection tool for infants with perinatal stroke.

Methods: Four stroke-affected infants were scanned with a DOT system within the first 3 days of life and compared to four healthy control subjects. Read More

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http://dx.doi.org/10.1038/s41390-018-0263-xDOI Listing
February 2019

Perinatal Iron Deficiency: Implications for Mothers and Infants.

Neonatology 2019 Feb 13;115(3):269-274. Epub 2019 Feb 13.

Georgetown University School of Medicine, Washington, District of Columbia,

Iron deficiency, with or without anemia, is common in pregnant women. In fact, nearly 30% of reproductive-age women are anemic worldwide, and anemia in pregnancy has an estimated global prevalence of 38%. Severe anemia can substantially increase the risk of maternal mortality, and can adversely affect fetal development. Read More

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http://dx.doi.org/10.1159/000495978DOI Listing
February 2019

Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder.

J Affect Disord 2019 Feb 6;249:63-72. Epub 2019 Feb 6.

Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland; Department of Psychiatry, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Psychiatry, Länsi-Pohja Healthcare District; Department of Psychiatry, the Middle Ostrobothnia Central Hospital, Soite; Mental Health Services, Joint Municipal Authority of Wellbeing in Raahe District; Mental Health Services and Basic Health Care District of Kallio; and Department of Psychiatry, Kainuu Central Hospital, Kainuu Social and Healthcare District, Finland.

Background: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders.

Methods: In the general population-based Northern Finland 1966 Birth Cohort with 12,058 children, 13. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.011DOI Listing
February 2019
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Degradation of Lung Protective Angiotensin Converting Enzyme-2 by Meconium in Human Alveolar Epithelial Cells: A Potential Pathogenic Mechanism in Meconium Aspiration Syndrome.

Lung 2019 Feb 13. Epub 2019 Feb 13.

Department of Physiology, Michigan State University, 3197 Biomedical and Physical Sciences Building, East Lansing, MI, 48824, USA.

Background: Pancreatic digestive enzymes present in meconium might be responsible for meconium-induced lung injury. The local Renin Angiotensin System plays an important role in lung injury and inflammation. Particularly, angiotensin converting enzyme-2 (ACE-2) has been identified as a protective lung enzyme against the insult. Read More

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http://dx.doi.org/10.1007/s00408-019-00201-yDOI Listing
February 2019

Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 13. Epub 2019 Feb 13.

Perinatal Research Center, University of Colorado School of Medicine, United States.

Intrauterine growth restricted (IUGR) fetal sheep have increased hepatic glucose production (HGP) that is resistant to suppression during a hyperinsulinemic-isoglycemic clamp (insulin-clamp). We hypothesized that the IUGR fetal liver would have activation of metabolic and signaling pathways that support HGP and inhibition of insulin signaling pathways. To test this, we used transcriptomic profiling with liver samples from control (CON) and IUGR fetuses receiving saline or an insulin-clamp. Read More

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http://dx.doi.org/10.1152/ajpregu.00359.2018DOI Listing
February 2019

Toll-Like Receptor 9, maternal cell-free dna and myometrial cell response to cpg oligodeoxynucleotide stimulation.

Am J Reprod Immunol 2019 Feb 13:e13100. Epub 2019 Feb 13.

Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, 43215.

Problem: Among mechanisms triggering onset of parturition, it has been recently postulated that Toll-Like Receptor (TLR)9 engagement by cell-free DNA (cfDNA) triggers inflammation, myometrial contractions and labor in absence of infection. The current study evaluated whether direct (myometrial) or indirect (decidual) TLR9 engagement enhances human myometrial contractility.

Method Of Study: TLR9 expression and cellular localization were surveyed by immunohistochemistry of placenta, fetal membranes, and myometrium in term (gestational age [GA]:>37 weeks) labor (TL, n=7) or term non-labor (TNL, n=7) tissues. Read More

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http://dx.doi.org/10.1111/aji.13100DOI Listing
February 2019