4,956 results match your criteria Journal of Pediatric Hematology/Oncology[Journal]


Neuroimaging Abnormalities in Patients With Nontransfusion-dependent Thalassemia.

J Pediatr Hematol Oncol 2019 Feb 12. Epub 2019 Feb 12.

Pediatric Hematology Oncology Unit, Advanced Pediatric Centre.

Independence from regular transfusions is the hallmark of nontransfusion-dependent thalassemia (NTDT). However, the associated complications need anticipation and screening. One such complication is a hypercoagulable state predisposing to development of thrombosis. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001432DOI Listing
February 2019
1 Read

Hepatosplenic Fungal Infections in Children With Leukemia-Risk Factors and Outcome: A Multicentric Study.

J Pediatr Hematol Oncol 2019 Feb 5. Epub 2019 Feb 5.

Division of Pediatric Hematology-Oncology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa.

Background: Invasive fungal infections, including hepatosplenic fungal infections (HSFI), cause significant morbidity and mortality in children with leukemia. There are not enough data to support for the best approach to diagnosis of HSFI in children, nor for the best treatment.

Procedure: In this multicentric study, we assessed the demographic data, clinical and radiologic features, treatment, and outcome of 40 children with leukemia and HSFI from 12 centers. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001431DOI Listing
February 2019

Pediatric Subcutaneous Panniculitis-like T-Cell Lymphoma With Hemophagocytosis Showing Complete Resolution With the BFM90 Protocol: Case Report and Review of Literature.

J Pediatr Hematol Oncol 2019 Feb 5. Epub 2019 Feb 5.

Clinical Haematology and Bone Marrow Transplantation, Christian Medical College, Ludhiana, Punjab.

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a distinct subtype of peripheral T-cell lymphoma associated with aggressive clinical behavior. Since its original description, it has continued to be a rare disease, and <200 cases have been reported in literature. We report an 11-year-old boy who presented with SPTCL and hemophagocytic lymphohistiocytosis (HLH) and responded to high-dose multiagent chemotherapy. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001434DOI Listing
February 2019
4 Reads

Identification of a Novel MYH9 Mutation in a Young Adult With Inherited Thrombocytopenia and Recurrent Seizures by Targeted Exome Sequencing.

J Pediatr Hematol Oncol 2019 Feb 1. Epub 2019 Feb 1.

Departments of Pediatrics.

May-Hegglin anomaly (MHA) is a rare autosomal dominant disorder caused by a mutation in the myosin heavy chain 9 (MYH9) gene. MHA patients have variable clinical manifestations including thrombocytopenia, renal injury, hearing impairment, and cataracts. We describe a 25-year-old man with isolated thrombocytopenia initially. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001430DOI Listing
February 2019
2 Reads
0.956 Impact Factor

Langerhans Cell Histiocytosis Presenting as Enterocolitis and Shock in Neonate.

J Pediatr Hematol Oncol 2019 Feb 1. Epub 2019 Feb 1.

Neonatal Unit, Doce de Octubre University Hospital, Madrid, Spain.

Introduction: Enterocolitis is a relatively common disease in neonatal period that can be a result of many underlying pathologies. One of them, which is an unusual disorder especially in neonatal age and with gastrointestinal involvement, is Langerhans cell histiocytosis (LCH). This case shows a severe neonatal LCH with digestive involvement which required intensive care and had an abnormal presentation, being hard to diagnose attributable to the diversity of symptoms. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001428DOI Listing
February 2019
1 Read

Emotion-Focused Avoidance Coping Mediates the Association Between Pain and Health-Related Quality of Life in Children With Sickle Cell Disease.

J Pediatr Hematol Oncol 2019 Feb 1. Epub 2019 Feb 1.

Department of Psychology, Georgia State University, Atlanta, GA.

Sickle cell disease (SCD) is associated with pain and decreased health-related quality of life (HRQOL). Coping strategies influence pain but have not been evaluated as mediating the relation between pain and HRQOL in pediatric SCD. The current study examined whether pain-related coping mediates the association between pain and HRQOL in children and adolescents with SCD. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001429DOI Listing
February 2019

Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells.

J Pediatr Hematol Oncol 2019 Jan 29. Epub 2019 Jan 29.

Division of Pediatric Oncology, Alberta Children's Hospital, and POETIC Laboratory for Preclinical and Drug Discovery Studies, University of Calgary, Calgary, AB.

Background: Recent studies have shown that cell cycle events are tightly controlled by complex and shared activities of a select group of kinases. Among these, polo-like kinases (Plks) are regulatory mitotic proteins that are overexpressed in several types of cancer and are associated with poor prognosis.

Materials And Methods: We have evaluated, in preclinical in vitro studies, the activity of a panel of Plk inhibitors against cell lines derived from refractory pediatric leukemia, as well as primary leukemia cells, in culture. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001416DOI Listing
January 2019
0.956 Impact Factor

Evaluation of Insulin-mediated Regulation of AKT Signaling in Childhood Acute Lymphoblastic Leukemia.

J Pediatr Hematol Oncol 2019 Jan 25. Epub 2019 Jan 25.

Department of Pediatrics, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen.

Objective: Hyperglycemia increases the risk of early recurrence and high mortality in some adult blood cancers. In response to increased glucose levels, insulin is secreted, and several studies have shown that insulin-induced AKT signaling can regulate tumor cell proliferation and apoptosis. The AKT pathway is aberrantly activated in adult acute lymphoblastic leukemia (ALL), but the mechanisms underlying this activation and its impact in pediatric patients with ALL are unclear. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001425DOI Listing
January 2019
1 Read

Prevention of Long-term Adverse Health Outcomes With Cardiorespiratory Fitness and Physical Activity in Childhood Acute Lymphoblastic Leukemia Survivors.

J Pediatr Hematol Oncol 2019 Jan 25. Epub 2019 Jan 25.

Laboratory of Pathophysiology of EXercise (LPEX), School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, University of Montreal.

Background: Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice of physical activity and a good cardiorespiratory fitness have the potential to reduce the risk of chronic disease and improve quality of life. The aim of this study was to evaluate in a cohort of ALL survivors, the association between a good cardiorespiratory fitness or the respect of physical activity guidelines and major long-term health outcomes. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001426DOI Listing
January 2019

Miscorrelation of Functional Outcome and Sociooccupational Status of Childhood, Adolescent, and Young Adult Generation With Bone and Soft Tissue Sarcoma Patients.

J Pediatr Hematol Oncol 2019 Jan 25. Epub 2019 Jan 25.

Department of Orthopedic Surgery.

Few studies have examined the relationship between functional outcome and sociooccupational or psychological status in adolescent and young adults (AYA) generation and childhood sarcoma patients. We retrospectively analyzed clinical (prognostic and functional) and sociooccupational outcomes in 50 patients; 22 children aged under 14 years and 28 AYAs generation (15 to 29 y). There were 35 cases of bone sarcomas and 15 of soft tissue sarcomas. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001410DOI Listing
January 2019
4 Reads

Gastric Carcinoma as Second Malignant Neoplasm in a Survivor From High-risk Neuroblastoma.

J Pediatr Hematol Oncol 2019 Jan 25. Epub 2019 Jan 25.

Departments of Pediatrics.

Childhood cancer survivors (CCSs) from high-grade malignancies, such as high-risk neuroblastoma, have been increased, and second malignant neoplasm, becomes a serious problem for CCSs. However, detailed reports about rare types of second cancer such as gastric cancer remain limited. We herein reported a female patient who developed diffuse type gastric carcinoma after 21 years from completion of treatment to high-risk neuroblastoma. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001409DOI Listing
January 2019

A 3-Year Retrospective Study of the Epidemiology of Acute Respiratory Viral Infections in Pediatric Patients With Cancer Undergoing Chemotherapy.

J Pediatr Hematol Oncol 2019 Jan 25. Epub 2019 Jan 25.

Pediatric Infection.

Background: Acute viral respiratory infections are common causes of febrile episodes in children. There are still limited data about distribution of acute viral respiratory infections in children with cancer.

Objective: The first aim of this study was to evaluate the viral etiology and seasonality of acute viral respiratory infection in pediatric patients with cancer in a 3-year study. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001418DOI Listing
January 2019
4 Reads

Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.

J Pediatr Hematol Oncol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Neurosciences.

Successful use of immune checkpoint inhibitors in a variety of cancers has generated interest in using this approach in pediatric brain tumors. We performed a retrospective review of 10 consecutive children (6 boys, 4 girls; ages, 2 to 17 y), with recurrent or refractory pediatric brain tumors (5 high-grade glioma, 1 low-grade glioma, pineoblastoma, medulloblastoma, ependymoma, and CNS embryonal tumor, NOS) treated at Rady Children's Hospital San Diego from 2015 to 2017 with the immune checkpoint inhibitor nivolumab (3 mg/kg every 2 wk). Eight of 10 patients received prior chemotherapy and 9 radiation therapy. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001339DOI Listing
October 2018
3 Reads

Watch and See Strategy in Selected Neuroblastoma Case Scenarios: Success and Limitations.

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

NCI, Cairo University.

Neuroblastoma (NBL) in infants has the potential to regress/mature spontaneously. The literature showed some cases, subjected to initial observation, with reasonable outcome. Deferring/avoiding active treatment was investigated in selected favorable NBL cases. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001421DOI Listing
January 2019

An 18-Year-Old Male With X-linked Lymphoproliferative Syndrome Type 1 Who Developed Primary Central Nervous System Lymphoma 6 Months After Primary Epstein-Barr Virus Infection.

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Departments of Pediatrics.

X-linked lymphoproliferative syndrome type 1 (XLP1) is a rare congenital immunodeficiency disease. We report the case of an 18-year-old male who developed hemophagocytic lymphohistiocytosis (HLH) with neurological complications after primary Epstein-Barr virus (EBV) infection and subsequently developed EBV-related central nervous system lymphoma (CNSL). Given the vulnerability to EBV, he was finally diagnosed with XLP1 and treated with whole-brain irradiation along with chemotherapy and subsequent allogeneic hematopoietic stem cell transplantation from a SH2D1A wild-type sibling donor. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001424DOI Listing
January 2019
4 Reads

Ganglioglioma in a Survivor of Infantile Glioblastoma.

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Departments of Pediatrics.

Congenital tumors account for 2% to 4% of all pediatric central nervous system tumors. Glioblastoma multiforme (GBM) represents a small subset of these tumors. Despite harboring histologic features similar to older patients, infants with GBM exhibit improved survival and respond more favorably to surgery and chemotherapy. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001417DOI Listing
January 2019
3 Reads

Metabolic Changes in Children that Received Chemotherapy.

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Faculty of Medicine, Universidad Anáhuac Puebla.

Cancer treatments are associated with short and long-effects. Epidemiological reports have revealed clinical features of metabolic syndrome (MS), obesity or overweight in young cancer survivors. The aim of the study was to examine the prevalence of unhealthy weight status and risk factors associated with MS related to chemotherapy. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001401DOI Listing
January 2019
1 Read

A Retrospective Analysis of Antithrombin III Replacement Therapy for the Treatment of Hepatic Sinusoidal Obstruction Syndrome in Children Following Hematopoietic Stem Cell Transplantation.

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Departments of Pediatrics.

Hepatic sinusoidal obstruction syndrome (SOS) remains a serious complication of hematopoietic stem cell transplantation (HSCT). In this single institution retrospective case series, 18 children developed SOS after HSCT. Patients were treated with antithrombin III (ATIII), defibrotide, or ATIII followed by defibrotide. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001422DOI Listing
January 2019
5 Reads

Chemoport-related Fungemia Caused by Trichosporon asahii.

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pharmacy Practice, Amrita School of Pharmacy.

Trichosporon asahii is a rare opportunistic fungal pathogen that causes fatal systemic infection in immunocompromised patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Invasive infections due to T. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001420DOI Listing
January 2019

Can Couples With MCV≥80, MCH<26, HbA2<3.2, HbF<3 be Classified as Low-risk β-Thalassemia Group?

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan.

Background And Aim: Thalassemia screening instructions in Iran categorizes couples with mean corpuscular volume (MCV)=75 to 80, mean corpuscular hemoglobin (MCH)=26 to 27, hemoglobin A2 (HbA2)<3.5, and hemoglobin fetal (HbF)<3 indices as low-risk couples, and therefore further genetic testing is not obligatory. This study examined the possibility of classifying couples with MCH<26 and MCV≥80 indices in the low-risk group when their HbF was <3 and HbA2 was <3. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001423DOI Listing
January 2019
2 Reads

Trametinib Toxicities in Patients With Low-grade Gliomas and Diabetes Insipidus: Related Findings?

J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Division of Haematology/Oncology.

Low-grade gliomas (LGG) represent the most common form of primary central nervous system tumor arising in childhood. There is growing evidence to support the role of the mitogen-activated protein kinase pathway in driving tumor growth and MEK inhibitors are being investigated in clinical trials for refractory and unresectable LGGs. As MEK inhibitors progress through clinical trials, drug toxicities have been identified. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001427DOI Listing
January 2019
8 Reads

Intensity of Therapy for Malignancy and Risk for Recurrent and Complicated Clostridium difficile Infection in Children.

J Pediatr Hematol Oncol 2019 Jan 16. Epub 2019 Jan 16.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Goryeb Children's Hospital, Morristown, NJ.

Clostridium difficile infection (CDI) is common in pediatric oncology patients and is often associated with recurrences and complications. We hypothesized that higher intensity of chemotherapy would be associated with these outcomes. We conducted a retrospective cohort study including all cases of primary CDI in children with malignancy in our institution for over 7 years. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001411DOI Listing
January 2019
4 Reads

Impact of IgG Monitoring and IVIG Supplementation on the Frequency of Febrile Illnesses in Pediatric Acute Lymphoblastic Leukemia Patients Undergoing Maintenance Chemotherapy.

J Pediatr Hematol Oncol 2019 Jan 16. Epub 2019 Jan 16.

Vanderbilt University School of Medicine.

Monitoring serum immunoglobulin G (IgG) levels in pediatric oncology patients and treating subtherapeutic levels with intravenous immunoglobulin (IVIG) may prevent infections; however, evidence is limited. This retrospective study assessed pediatric acute lymphoblastic leukemia patients diagnosed 2006 to 2011 to evaluate if monitoring/supplementing IgG would reduce febrile illnesses during maintenance chemotherapy. A subject was categorized as "ever IgG monitored" if they had ≥1 IgG levels checked and their risk days were stratified into not IgG monitored days and IgG monitored days. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001415DOI Listing
January 2019
13 Reads

Improved Outcome of Newly Diagnosed Childhood Mature B-Cell Lymphoma/Leukemia With High Tumor Burden Treated With BFM95-based Protocol Combining Rituximab: A Report From Shanghai, China.

J Pediatr Hematol Oncol 2019 Jan 16. Epub 2019 Jan 16.

Department of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.

In this study we evaluated children with newly diagnosed advanced (stage III and stage IV) mature B-cell non-Hodgkin lymphoma (B-NHL) or mature B-cell acute leukemia (B-AL), who were treated with Berlin-Frankfurt-Münster (BFM)95-based protocol combined with rituximab (R+BFM95). Our study recruited 46 patients who were treated with BFM95 protocol combined with rituximab. There are 23 patients as the historical control treated with BFM90 protocol. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001419DOI Listing
January 2019
1 Read

Minimal Residual Disease-guided Risk Restratification and Therapy Improves the Survival of Childhood Acute Lymphoblastic Leukemia: Experience From a Tertiary Children's Hospital in China.

J Pediatr Hematol Oncol 2019 Jan 11. Epub 2019 Jan 11.

Department of Hematology-Oncology, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China.

The minimal residual disease (MRD) has been shown to be very important to evaluate the prognostic significance in childhood acute lymphoblastic leukemia (ALL), but the impact under the current treatment protocol in China has not been fully elucidated. The aim of this study was to investigate the efficacy of MRD-guided risk restratification of ALL. A total of 676 children with ALL were enrolled. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001412DOI Listing
January 2019
1 Read

Human Fibrinogen Concentrate and Fresh Frozen Plasma in the Management of Severe Acquired Hypofibrinogenemia in Children With Acute Lymphoblastic Leukemia: Results of a Retrospective Survey.

J Pediatr Hematol Oncol 2019 Jan 11. Epub 2019 Jan 11.

Division of Paediatric Haematology Oncology-Azienda Ospedaliera Universitaria Policlinico Consorziale di Bari, Bari.

Objective Of The Study: In this study we aimed to retrospectively evaluate how centers, belonging to the Associazione Italiana Ematologia e Oncologia Pediatrica (AIEOP), manage severe acquired hypofibrinogenemia in children with acute lymphoblastic leukemia, particularly evaluating the therapeutic role of human fibrinogen concentrate (HFC) and fresh frozen plasma (FFP).

Methods: We conducted a survey among AIEOP centers; thereafter, we collected and analyzed data with regard to the treatment of episodes of severe acquired hypofibrinogenemia occurring during the induction and reinduction phases of the AIEOP-BFM ALL 2009 protocol.

Results: In total, 15 of the 37 AIEOP centers invited to join the survey agreed to collect the data, with 10 and 5 centers declaring to react to severe acquired hypofibrinogenemia (<70 mg/dL) by administering HFC or FFP, respectively. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001390DOI Listing
January 2019
1 Read

Pediatric Osteosarcoma of Extremities: A 15-year Experience From a Tertiary Care Cancer Center in Upper Egypt.

J Pediatr Hematol Oncol 2019 Jan 8. Epub 2019 Jan 8.

Medical Oncology, South Egypt Cancer Institute, Assiut University.

Aim: To assess the outcome and determine predictors of survival in pediatric patients with osteosarcoma of the extremities treated with a unified chemotherapy protocol at a single institution over a 15-year period.

Materials And Methods: We performed a retrospective analysis of medical records of 48 pediatric patients with histologically verified osteosarcoma of the extremities diagnosed at South Egypt Cancer Institute and received treatment between January 2001 and December 2015.

Results: With a median follow-up of 61 months for the entire cohort, estimates of overall survival (OS) for 3- and 5-year were 50. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001407DOI Listing
January 2019
1 Read

Successful Management of Hepatosplenic Infection Due to Saccharomyces cerevisiae in a Child With Acute Lymphoblastic Leukemia.

J Pediatr Hematol Oncol 2019 Jan 8. Epub 2019 Jan 8.

Departments of Paediatric Blood and Marrow.

Saccharomyces cerevisiae is an emerging pathogen within the immunocompromised. We present a 4-year-old boy with acute lymphoblastic leukemia presenting with polymerase chain reaction-confirmed hepatosplenic S. cerevisiae infection and significant immune reconstitution symptoms. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001403DOI Listing
January 2019
8 Reads

Impact of Race and Socioeconomic Status on Psychological Outcomes in Childhood Cancer Patients and Caregivers.

J Pediatr Hematol Oncol 2019 Jan 8. Epub 2019 Jan 8.

Departments of Pediatrics, Division of Hematology/Oncology.

Complex relationships between race and socioeconomic status have a poorly understood influence on psychological outcomes in pediatric oncology. The Family Symptom Inventory was used to assess symptoms of depression and anxiety in pediatric patients with cancer and their caregivers. Separate hierarchical linear regression models examined the relationship between demographic variables, cancer characteristics, socioeconomic status, and access to care and patient or caregiver depression/anxiety. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001405DOI Listing
January 2019
3 Reads

Presentation of Compound Heterozygous Hemoglobin Constant Spring and Hemoglobin Pakse in Neonates.

J Pediatr Hematol Oncol 2019 Jan 5. Epub 2019 Jan 5.

Departments of Pediatrics.

Background: Mutations causing α thalassemia are divided into deletion and nondeletion groups. In the nondeletion group, hemoglobin constant spring (Hb CS) and hemoglobin Pakse (Hb Pakse) are both caused by a termination codon mutation leading to elongation of the α2 globin gene. In the case of Hb CS, the mutation is TAA→CAA, whereas the mutation causing Hb Pakse is TAA→TAT. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001406DOI Listing
January 2019
2 Reads

Early Deaths in Pediatric Acute Leukemia: A Major Challenge in Developing Countries.

J Pediatr Hematol Oncol 2019 Jan 5. Epub 2019 Jan 5.

Departments of Pediatric Oncology.

Children with acute leukemia may experience high treatment-related mortality, which often occurs early in the induction phase. The aim of the study was to assess the incidence and risk factors related to increased mortality during induction therapy of pediatric patients with acute leukemia. This is a retrospective study that included pediatric acute leukemia patients who presented to the National Cancer Institute, Cairo University, between January 2011 and December 2013. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001408DOI Listing
January 2019
1 Read
0.956 Impact Factor

Multimodal Management of Congenital Orbital Malignant Rhabdoid Tumor: Review of Literature and Report of a Rare Case.

J Pediatr Hematol Oncol 2019 Jan 4. Epub 2019 Jan 4.

Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Malignant rhabdoid tumor (MRT) is a rare and aggressive tumor with a dismal prognosis. It commonly arises in the brain (65%), soft tissues (26%), and the kidney (9%). Primary orbital involvement is extremely rare. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001402DOI Listing
January 2019
4 Reads

Efficacy and Safety of Recombinant Activated Factor VII Off-label Use in a Pediatric Hematology/Oncology Cohort.

J Pediatr Hematol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Departments of Hematology.

Background: Recombinant activated factor VII (rFVIIa) has been used off-label to treat or prevent severe bleeding in patients for whom conventional treatments are unsuccessful. However, studies in children remain limited.

Procedure: To examine the efficacy and safety of rFVIIa, we performed a retrospective analysis of rFVIIa off-label use in a pediatric hematology/oncology cohort at a single center from 2006 to 2014. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001379DOI Listing
January 2019

Safety and Cost-effectiveness of Outpatient Administration of High-dose Chemotherapy in Children With Ewing Sarcoma.

J Pediatr Hematol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Department of Pediatrics, King Hussein Cancer Center.

Background: Children with Ewing sarcoma (ES) are subjected to an interval-compressed regimen with cycles of chemotherapy given every 2 weeks, which is nowadays considered to be the standard of care for individuals with such a case. We developed institutional clinical practice guidelines (CPG) applying outpatient administration in regard to this regimen. This study intends to evaluate our institutional experience with this regimen. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001396DOI Listing
January 2019
1 Read

Typhoid Fever Accompanied With Hematopoetic Lymphohistiocytosis and Rhabdomyolysis in a Refugee Child.

J Pediatr Hematol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Departments of Pediatric Hematology and Oncology.

Typhoid fever is an acute and systemic infectious disease that is specific to humans and is caused by Salmonella typhi. Patients may present with different findings ranging from simple fever to multiple organ failure. Hemophagocytosis and rhabdomyolysis are rare complications of typhoid fever. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001400DOI Listing
January 2019
9 Reads

A Rare Diagnosis in Children: Burkitt Leukemia Associated With Mediastinal Germ Cell Tumors.

J Pediatr Hematol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Department of Genetics, University of Health Sciences, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1097/MPH.0000000000001404DOI Listing
January 2019
3 Reads

Haemophagocytic Lymphohistiocytosis Associated With 2 Cases of Pediatric Lymphocyte-depleted Classic Hodgkin Lymphoma.

J Pediatr Hematol Oncol 2018 Dec 27. Epub 2018 Dec 27.

Birmingham Children's Hospital, Steelhouse Lane, Birmingham, UK.

Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal syndrome of abnormal T-cell activation and cytokine production, which can be familial or secondary in nature. Although HLH can occur concomitantly with lymphomas, the development of HLH alongside Hodgkin lymphoma in children is unusual. Here we report the diagnostic evaluation and clinical course of 2 pediatric cases of HLH secondary to lymphocyte-depleted classic Hodgkin lymphoma. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001398DOI Listing
December 2018

Effectiveness and Safety of 4-factor Prothrombin Complex Concentrate (4PCC) in Neonates With Intractable Bleeding or Severe Coagulation Disturbances: A Retrospective Study of 37 Cases.

J Pediatr Hematol Oncol 2018 Dec 27. Epub 2018 Dec 27.

2nd Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki.

Background: To date, clinical experience with prothrombin complex concentrate (PCC) in the neonatal population has been limited.

Aim: The objective of this study was to describe our experience regarding the effectiveness and safety of PCC administration in newborns with severe bleeding or coagulopathy resistant to conventional therapy.

Methodology: We retrospectively analyzed data from 37 neonates with intractable bleeding or severe coagulation disturbances. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001397DOI Listing
December 2018
1 Read

Long-term Efficacy of Single-agent Vemurafenib for Pleomorphic Xanthoastrocytoma.

J Pediatr Hematol Oncol 2018 Dec 27. Epub 2018 Dec 27.

Departments of Pediatrics, Division of Pediatric Hematology-Oncology.

Pleomorphic xanthoastrocytoma is a malignant brain tumor that has a good prognosis with complete resection but does not respond well to chemotherapy if there is residual tumor. BRAFV600E mutations are common in pleomorphic xanthoastrocytomas and provide an additional means for treatment when excision is not possible. Monotherapy with the BRAF V600E inhibitor vemurafenib has only been reported in a small number of cases and mostly in adults. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001395DOI Listing
December 2018
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Prevalence and Outcome of HIV-associated Malignancies Among HIV-infected Children Enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: A Hospital-based Retrospective Analytical Study.

J Pediatr Hematol Oncol 2018 Dec 27. Epub 2018 Dec 27.

Kilimanjaro Christian Medical University College.

Objective: We aimed to establish the prevalence of human immunodeficiency virus (HIV)-associated malignancies in children attending a care and treatment clinic at Kilimanjaro Christian Medical Centre.

Materials And Methods: This was a retrospective cross-sectional hospital-based study of children who attended an HIV care and treatment clinic between 2006 and 2014. Children aged 2 months to 17 years were eligible for participation. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001389DOI Listing
December 2018
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Identification of Homozygous Somatic DICER1 Mutation in Pleuropulmonary Blastoma.

J Pediatr Hematol Oncol 2018 Dec 21. Epub 2018 Dec 21.

Department of Pediatrics, Gifu University Graduate School of Medicine.

Pleuropulmonary blastoma (PPB) is a rare, progressive, and aggressive malignant intrathoracic tumor observed during childhood. Mutations in the DICER1 gene have been considered a major etiologic factor of PPB and cause a variety of tumor types in children and young adults. We present a 3-year-old boy with type II PPB. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001392DOI Listing
December 2018
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Beliefs and Adherence Associated With Oral and Infusion Chelation Therapies in Jordanian Children and Adolescents With Thalassemia Major: A Comparative Study.

J Pediatr Hematol Oncol 2018 Dec 21. Epub 2018 Dec 21.

Faculty of Nursing, Zarqa University, Jordan.

The researcher assessed the beliefs and adherence associated with both oral deferasirox and deferoxamine infusion chelation therapies among Jordanian children with thalassemia major, and compared the adherence levels between the recipients of each. In this descriptive cross-sectional study, 120 participants were recruited from 3 major thalassemia treatment clinics in Jordan using convenience sampling. Data were collected through questionnaires on demographic- and disease-related information, the beliefs about medicines, and a medication adherence report scale. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001399DOI Listing
December 2018
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A Novel Mutation of Glucose Phosphate Isomerase (GPI) Causing Severe Neonatal Anemia Due to GPI Deficiency.

J Pediatr Hematol Oncol 2018 Dec 21. Epub 2018 Dec 21.

Department of Pediatrics, Alrijne Hospital, Leiderdorp.

Glucose-6-phosphate isomerase (GPI) deficiency is very rare, but one of the most common erythroenzymopathies, causing hereditary nonspherocytic hemolytic anemia. This case report describes the clinical features and the molecular etiology of a Dutch patient with GPI deficiency. She is the fifth patient with GPI deficiency identified to date in the Netherlands and was found to be compound heterozygous for the previously reported c. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001393DOI Listing
December 2018
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Improved Outcome in Local Ewing Sarcoma With an Intensified Pilot Treatment Protocol SCMCIE 94.

J Pediatr Hematol Oncol 2018 Dec 18. Epub 2018 Dec 18.

The Rina Zaizov Department of Pediatric Hematology-Oncology.

This study evaluated the effect of an intensified pilot protocol, SCMCIE 94, on the outcome of Ewing sarcoma (EWS). The cohort included 121 patients with local or metastatic EWS treated at a tertiary pediatric medical center with the SCMCIE 94 (protocol 3, 1994 to 2011) or an earlier protocol (protocol 2, 1988 to 1994; protocol 1, 1985 to 1988). All protocols included 4 to 6 courses of chemotherapy, radiation, and surgery. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001384DOI Listing
December 2018
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Low-dose Immune Tolerance Induction: A Single-Center Experience.

J Pediatr Hematol Oncol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pediatric Hematology and Oncology, Cerrahpasa Medical Faculty and Oncology Institute, Istanbul University, Istanbul, Turkey.

Introduction: The development of inhibitors against factors VIII/IX is the most serious complication in hemophilia. The best treatment strategy for inhibitor eradication is immune tolerance induction (ITI). The aim of this study was to evaluate patients treated with low-dose ITI at a single center with limited resources. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001391DOI Listing
December 2018
2 Reads

Differences of Immune Reconstitution of Dendritic Cells in Pediatric GvHD Patients After Allogenic Stem Cell Transplantation.

J Pediatr Hematol Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Pediatric Hematology and Oncology, University Hospital Würzburg, Germany.

Background: Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure for children with a variety of (non) malignant conditions. GvHD is a severe complication with high morbidity and mortality. The pathogenesis remains unclear. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001342DOI Listing
November 2018
2 Reads

Expression and Activity of Matrix Metalloproteinases in Leukemia.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Matrix metalloproteinases (MMPs) are responsible for the degradation of extracellular matrix components and hence play a crucial role in physiological and pathologic processes. The imbalance between the expression of MMPs and their inhibitors can be effective in leukemic cell processes such as migration, angiogenesis, survival, and apoptosis, playing a key role in the progression and prognosis of leukemia. In this review, we discuss the potential involvement of MMPs and their inhibitors in the pathogenesis and progression of leukemia by examining their role in the prognosis of leukemia. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001386DOI Listing
December 2018
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Intracranial Hemorrhage in Children With Inherited Bleeding Disorders: A Single Center Study in China.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Intracranial hemorrhage (ICH) is a life-threatening condition in children. Inherited bleeding disorders (IBD) have high risk of ICH.

Aim: This single center study aims to identify the incidence, risk factors, and neurological outcome of ICH in children who suffer from IBD. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001358DOI Listing
December 2018
3 Reads

Causes of Hypochromic Microcytic Anemia in Children and Evaluation of Laboratory Parameters in the Differentiation.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Kanuni Sultan Suleyman Training and Research Hospital, Pediatric Hematology Oncology, Istanbul, Turkey.

Most common causes of microcytic anemia in children are iron deficiency anemia (IDA) and thalassemia. Differentiation of these and detection of coexistence is essential for genetic counseling and to set a treatment plan. Aim is to characterize the frequency of IDA and thalassemia trait (TT) in children presenting with hypochromic, microcytic anemia and to define the significance of blood count parameters in differential diagnosis. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001382DOI Listing
December 2018
19 Reads

Disease-specific Hospitalizations Among 5-Year Survivors of Hepatoblastoma: A Nordic Population-based Cohort Study.

J Pediatr Hematol Oncol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Aarhus University Hospital.

Introduction: The long-term risk of somatic disease in hepatoblastoma survivors has not been thoroughly evaluated in previous studies. In this population-based study of 86 five-year HB survivors, we used inpatient registers to evaluate the risk for a range of somatic diseases.

Methods: In total, 86 five-year survivors of hepatoblastoma were identified in the Nordic cancer registries from 1964 to 2008 and 152,231 population comparisons were selected. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001378DOI Listing
December 2018
8 Reads