9,987 results match your criteria Journal of Pediatric Gastroenterology and Nutrition[Journal]


Development of Infliximab Target Concentrations during Induction in Pediatric Crohn's Disease Patients.

J Pediatr Gastroenterol Nutr 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objectives: Subtherapeutic drug concentrations contribute to both primary and secondary nonresponse to infliximab in children with Crohn's disease (CD). The aim of this study was to evaluate treatment outcomes and infliximab concentrations at infusions 2 and 3 with an objective to establish infliximab targets during induction for primary responders.

Methods: Single-center, prospective cohort of anti-TNF naïve CD patients < 22 years old starting infliximab. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002304DOI Listing
February 2019

Diffuse Gastric Bleed Managed with Hemospray in a 15-Year-Old Patient.

J Pediatr Gastroenterol Nutr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, Johns Hopkins University School of Medicine.

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http://dx.doi.org/10.1097/MPG.0000000000002305DOI Listing
February 2019

Gastric Adenocarcinoma: A Rare Cause of Abdominal Pain and Anemia in a 14 y/o Patient.

J Pediatr Gastroenterol Nutr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatric Gastroenterology, University of Nebraska School of Medicine, Children's Hospital of Omaha.

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http://dx.doi.org/10.1097/MPG.0000000000002312DOI Listing
February 2019

"Y" in the Gall Bladder Fossa: Think of Duplicated Gall Bladder.

J Pediatr Gastroenterol Nutr 2019 Feb 5. Epub 2019 Feb 5.

Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.

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http://dx.doi.org/10.1097/MPG.0000000000002303DOI Listing
February 2019

Editorial: Treating Biliary Atresia: The Challenge Continues.

J Pediatr Gastroenterol Nutr 2019 Feb 5. Epub 2019 Feb 5.

Department of Pediatrics, University of CA, San Francisco.

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http://dx.doi.org/10.1097/MPG.0000000000002302DOI Listing
February 2019

A Novel VPS33B Mutation Causing a Mild Phenotype of ARC Syndrome.

J Pediatr Gastroenterol Nutr 2019 Feb 5. Epub 2019 Feb 5.

Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, PA.

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http://dx.doi.org/10.1097/MPG.0000000000002306DOI Listing
February 2019
1 Read

Young Age Predicts Acute Pancreatitis Severity in Children.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Pediatric Gastroenterology, Hepatology and Nutrition Clinic, Dana-Dwek Children's Hospital, The Tel-Aviv Medical Center and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Objectives: The course and evolution of pediatric acute pancreatitis (AP) is poorly understood. Prognostication models in children perform poorly and lack consensus. We aimed to identify predictors of AP severity, and the risk for AP recurrence. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002294DOI Listing
February 2019

Mean Corpuscular Volume to White Blood Cell Ratio for Thiopurine Monitoring in Pediatric Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Division of Pediatric Gastroenterology, Ann Arbor, MI.

Objectives: Thiopurines, commonly used to treat inflammatory bowel disease (IBD), cause lymphopenia and red blood cell macrocytosis, requiring therapeutic monitoring. Mean corpuscular volume/white blood cell (MCV/WBC) ratio has been proposed as a surrogate for therapeutic monitoring. Our aim was to investigate MCV/WBC ratio for assessing clinical response to thiopurines among pediatric IBD patients. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002296DOI Listing
February 2019
1 Read

Risk-factors Associated with Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA.

Very early onset inflammatory bowel disease (VEO-IBD) represents a diagnostic and treatment challenge. Here we present a case of VEO-IBD secondary to a mutation in BIRC4 gene, which encodes X-linked inhibitor of apoptosis protein (XIAP), in a 17 month-old male with severe failure to thrive, intractable diarrhea and hepatosplenomegaly. Endoscopy and histology identified only mild duodenitis and ileitis, but severe pancolitis with crypt abscesses and epithelium apoptosis. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002297DOI Listing
February 2019
6 Reads

HLA-DQ Genotyping, Duodenal Histology, and Response to Exclusion Diet in Autistic Children With Gastrointestinal Symptoms.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Division of Gastroenterology and Hepatology, Città Della Salute e Della Scienza di Torino Hospital.

Objectives: A correlation between autism spectrum disorders (ASDs) and gastrointestinal (GI) problems, and a possible link between gluten consumption and ASD have been increasingly reported. Gluten/casein-free diet (GCFD) is often undertaken, with conflicting results. This study aimed at evaluating the distribution of human leukocyte antigen (HLA)-DQ2/DQ8 typing among patients with ASD with GI symptoms, together with its correlation with duodenal histology and response to GCFD. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002293DOI Listing
February 2019
1 Read

Magnetically Controlled Capsule Endoscopy in Children: A Single Center, Retrospective Cohort Study.

J Pediatr Gastroenterol Nutr 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China.

Objective: Capsule endoscopy (CE) is a noninvasive diagnostic tool for the digestive tract. We aim to investigate the feasibility and safety of newly-developed magnetically controlled capsule endoscopy (MCE) in children.

Methods: A total of 129 children who underwent MCE in Shanghai Children's Hospital were retrospectively recruited between March 2016 and August 2018. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002292DOI Listing
February 2019
2 Reads

The Simple Pediatric Activity Ultrasound Score (SPAUSS) for the Accurate Detection of Pediatric Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2019 Feb 4. Epub 2019 Feb 4.

Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, University of Calgary, Calgary Alberta.

Objective: To identify the most significant ultrasound (US) parameters that predict inflammatory activity and develop a simple US activity score.

Methods: Patients were identified through retrospective evaluation of an established database of children with inflammatory bowel disease (IBD). Patients with endoscopy and US within 60 days were included (N = 75). Read More

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http://dx.doi.org/10.1097/MPG.0000000000002298DOI Listing
February 2019
1 Read

Deepening the Understanding of Functional and Motility Disorders.

Authors:
Rachel Rosen

J Pediatr Gastroenterol Nutr 2019 Feb 4. Epub 2019 Feb 4.

Center for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115.

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http://dx.doi.org/10.1097/MPG.0000000000002300DOI Listing
February 2019

Measurement of Microvascular Function in Pediatric Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2019 Feb 4. Epub 2019 Feb 4.

Harvard Medical School MassGeneral Hospital for Children.

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http://dx.doi.org/10.1097/MPG.0000000000002299DOI Listing
February 2019

Epithelial Claudin Proteins and their Role in Gastrointestinal Diseases.

J Pediatr Gastroenterol Nutr 2019 Feb 4. Epub 2019 Feb 4.

Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine.

Our bodies are protected from the external environment by mucosal barriers that are lined by epithelial cells. The epithelium plays a critical role as a highly dynamic, selective semipermeable barrier that separates luminal contents and pathogens from the rest of the body as well as controlling the absorption of nutrients, fluid and solutes (1, 2). A series of protein complexes including the adherens junction, desmosomes, and tight junctions (TJ) function as the principal barrier in paracellular diffusion (3) as well as regulators of intracellular solute, protein and lipid transport (4). Read More

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http://dx.doi.org/10.1097/MPG.0000000000002301DOI Listing
February 2019

Neonatal Liver Failure with Hemophagocytosis and Skin Rash.

J Pediatr Gastroenterol Nutr 2019 Feb 4. Epub 2019 Feb 4.

Liver Unit and Small Bowel Transplantation, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1097/MPG.0000000000002295DOI Listing
February 2019

The Impact of Increased Allocation Priority for Children Awaiting Liver Transplant: A Liver Simulated Allocation Model (LSAM) Analysis.

J Pediatr Gastroenterol Nutr 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatrics, University of Washington, Seattle, WA.

Objective: To investigate the impact of prioritizing infants, children, adolescents and the sickest adults (Status 1) for deceased donor livers. We compared outcomes under two "SharePeds" allocation schema, which prioritize children and Status 1 adults for national sharing and enhanced access to (1) pediatric donors or (2) all donors <35 years old, to outcomes under the allocation plan approved by the Organ Procurement and Transplant Network in December 2017 (OPTN 12-2017).

Methods: The 2017 Liver Simulated Allocation Model (LSAM) and Scientific Registry of Transplant Recipients (SRTR) data on all U. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002287DOI Listing
January 2019

Comparison of Transjugular Liver Biopsy and Percutaneous Liver Biopsy with Tract Embolization in Pediatric Patients.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Lucile Packard Children's Hospital, 725 Welch Road, Room 1862, Stanford, CA 94305.

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http://dx.doi.org/10.1097/MPG.0000000000002290DOI Listing
January 2019
2 Reads

Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children: A Systematic Review.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Amsterdam UMC - location AMC, Amsterdam, The Netherlands.

Objectives: Gastroesophageal reflux disease (GERD) is defined as GER causing troublesome symptoms or complications. In this study we reviewed the literature regarding the prevalence of GERD symptoms in infants and children.

Methods: Databases of PubMed, EMBASE and Cochrane were systematically searched from inception to June 26, 2018. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002280DOI Listing
January 2019
1 Read

Transjugular Liver Biopsy vs Percutaneous Liver Biopsy with Tract Embolization in Children with Coagulopathy.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi - 110070.

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http://dx.doi.org/10.1097/MPG.0000000000002289DOI Listing
January 2019
1 Read
2.625 Impact Factor

Dietary Therapy in Conjunction with Immunosuppression to Treat Gastrointestinal Graft-Versus-Host Disease (GVHD).

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics, Division of Gastroenterology, Seattle Children's Hospital and the University of Washington.

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http://dx.doi.org/10.1097/MPG.0000000000002288DOI Listing
January 2019
2 Reads

Microscopic / "Backwash" Ileitis and its Association with Colonic Disease in New Onset Pediatric Ulcerative Colitis.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pathology, Children's Hospital Boston, Boston, MA, USA.

Background: Microscopic ileitis and its association with pancolitis in adults with ulcerative colitis (UC) has been described. However, the incidence of ileitis and associations with colonic disease in pediatric UC have not been thoroughly investigated. This study was undertaken to examine the prevalence of microscopic ileal inflammation at the time of initial diagnosis in a cohort of children with UC. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002272DOI Listing
January 2019

Healthy Body Weights With Corticosteroid-Free Immunosuppression Is The Best Predictor of Cardiovascular Health In Children After Liver Transplantation.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics, University of Alberta.

Introduction: Cardio-metabolic dysregulation (CMD) influences morbidity and mortality risk in adults post-liver transplantation (LTx). CMD is reported in 10-25% of pediatric LTx recipients, but no information regarding the longitudinal expression of CMD is available. The study objective was to examine the longitudinal expression of CMD and associations with body composition and growth in children post-LTx. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002271DOI Listing
January 2019
4 Reads

Predisposing Conditions to Pediatric Hepatocellular Carcinoma and Association with Outcomes: Single-Center Experience.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Pediatrics- Gastroenterology, Baylor College of Medicine.

Objectives: Hepatocellular carcinoma (HCC) has been linked to chronic viral or metabolic liver disease and other conditions. The characteristics of children with HCC have not been fully elucidated and outcomes in children with predisposing liver disease are not well defined.

Methods: Patients ≤ 21 years old with HCC managed at our institution and through external consultation between 1996 and 2016 were included. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002285DOI Listing
January 2019
4 Reads

Similarities and Differences in Allocation Policies for Pediatric Liver Transplantation Across the World.

J Pediatr Gastroenterol Nutr 2019 01 21. Epub 2019 Jan 21.

Icahn School of Medicine at Mount Sinai, Department of Pediatrics and Recanati Miller Transplant Institute 1 Gustave Levy, New York, United States.

Objectives: We aimed to investigate national allocation policies for pediatric liver transplantation.

Method: A survey was prepared by the ESPGHAN hepatology committee in collaboration with the North-American SPLIT (Studies of Pediatric Liver Transplantation) consortium. The survey was sent to pediatric hepatologists and transplant surgeons worldwide. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002283DOI Listing
January 2019

Confusion Over Breast Milk Substitutes.

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):e41-e42

World Health Organization, Geneva, Switzerland.

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http://dx.doi.org/10.1097/MPG.0000000000002222DOI Listing
February 2019

Lean Nonalcoholic Fatty Liver Disease: Should It Be Considered in Lean Adolescents With Elevated Liver Enzymes?

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):e40-e41

Department of Pediatric Gastroenterology and Hepatology.

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http://dx.doi.org/10.1097/MPG.0000000000002214DOI Listing
February 2019

Pediatric Chronic Inflammatory Bowel Disease in a German Statutory Health INSURANCE-Incidence Rates From 2009 to 2012.

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):244-250

Institute for Social Pediatrics and Adolescents Medicine, Ludwig Maximilians University.

Objective: The incidence of pediatric inflammatory bowel disease (PIBD) varies over time and geographic region. We attempted to generate incidence rates form German health insurance data.

Methods: We used health care data for 2009-2015 provided by BARMER, a major statutory health insurance company in Germany, insuring approximately 8% of the pediatric population. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002162DOI Listing
February 2019

The Brussels Infant and Toddler Stool Scale: A Study on Interobserver Reliability.

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):207-213

KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Objectives: The Bristol Stool Form Scale (BSFS) is inadequate for non-toilet trained children. The Brussels Infant and Toddler Stool Scale (BITSS) was developed, consisting of 7 photographs of diapers containing stools of infants and toddlers. We aimed to evaluate interobserver reliability of stool consistency assessment among parents, nurses, and medical doctors (MDs) using the BITSS. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002153DOI Listing
February 2019
1 Read

Alloimmunity and Cholestasis After Liver Transplantation in Children With Progressive Familial Intrahepatic Cholestasis.

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):169-174

University Children's Hospital, Pediatric Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg.

Objectives: Bile salt export pump (BSEP) deficiency is an important reason for chronic cholestasis leading to liver transplantation (LT) in early childhood. The underlying pathology is a dysfunction of BSEP due to various mutations in the ABCB11 gene. Cases of clinical recurrence after LT due to alloantibodies directed against BSEP (antibody-induced BSEP deficiency [AIBD]) have been reported. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002200DOI Listing
February 2019

2018 AAP Murray Davidson Award - David Piccoli.

Authors:
Binita M Kamath

J Pediatr Gastroenterol Nutr 2019 Jan 17. Epub 2019 Jan 17.

Staff Physician, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Senior Associate Scientist, Research Institute, Associate Professor, University of Toronto.

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http://dx.doi.org/10.1097/MPG.0000000000002276DOI Listing
January 2019

Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis In A Girl With Ulcerative Colitis.

J Pediatr Gastroenterol Nutr 2019 Jan 17. Epub 2019 Jan 17.

Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume.

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http://dx.doi.org/10.1097/MPG.0000000000002281DOI Listing
January 2019
1 Read

Size and Prevalence of Pediatric Aerodigestive Programs in 2017.

J Pediatr Gastroenterol Nutr 2019 Jan 17. Epub 2019 Jan 17.

Aerodigestive Program, Digestive Health Institute, Children's Hospital Colorado, University of Colorado, School of Medicine, Aurora, CO.

Objective: Pediatric aerodigestive programs appear to be rapidly proliferating and provide multi-disciplinary, coordinated care to complex, medically-fragile children. Pediatric subspecialists are considered essential to these programs. This study evaluated the state of these programs in 2017 by surveying their size, composition, prevalence, and the number of patients that they serve. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002268DOI Listing
January 2019
1 Read

Biliary Tract Disease in Girls and Young Women with Rett Syndrome.

J Pediatr Gastroenterol Nutr 2019 Jan 17. Epub 2019 Jan 17.

Civitan International Research Center.

Objective: We reviewed medical records and conducted a nationwide survey to characterize the clinical features and determine the prevalence of biliary tract disease in girls and women with Rett syndrome (RTT).

Methods: Sixty-two individuals with RTT and biliary tract disease were identified from the membership of Rett Syndrome Organization (RS.O) and patient files of the principal investigator. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002273DOI Listing
January 2019
2 Reads

Insights into Pediatric Autoimmune Gastritis: Is There a Role for Helicobacter Pylori Infection?

J Pediatr Gastroenterol Nutr 2019 01 17. Epub 2019 Jan 17.

Pediatric Gastroenterology Unit. Centro Materno Infantil do Norte - CMIN. Centro Hospitalar Universitário do Porto. Porto, Portugal.

Objectives: Autoimmune gastritis (AIG) is a chronic inflammatory condition of the gastric mucosa, mainly described in adults presenting with pernicious anemia. It results from antibody-mediated destruction of parietal cells, but the precise initiating event is unknown. The pathogenicity of Helicobacter pylori (H. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002278DOI Listing
January 2019
2 Reads

Diagnostic and Therapeutic Approach in Paediatric Inflammatory Bowel Diseases - Results from a Clinical Practice Survey.

J Pediatr Gastroenterol Nutr 2019 Jan 17. Epub 2019 Jan 17.

GPGE-Educational Center for Paediatric Gastroenterology, Department of Paediatrics, Medical University of Graz, Graz, Austria.

Objectives: Despite existence of international guidelines for diagnosis and management of inflammatory bowel diseases (IBD) in children, there might be differences in the clinical approach.

Methods: A survey on clinical practice in paediatric IBD was performed among members of the ESPGHAN Porto IBD working group and interest group, PIBD-NET, and IBD networks in Canada and German speaking countries (CIDsCANN, GPGE), using a web-based questionnaire. Responses to 63 questions from 106 paediatric IBD centres were collected. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002233DOI Listing
January 2019
1 Read
2.625 Impact Factor

Barriers in Neurogastroenterology and Motility Training Experience for Pediatric Gastroenterology Fellows.

J Pediatr Gastroenterol Nutr 2019 Jan 17. Epub 2019 Jan 17.

Division of Pediatric Gastroenterology, Children's Hospital of Philadelphia, Philadelphia, PA.

Background: Neurogastroenterology and motility (NGM) disorders are common and have a high health care burden. Although pediatric gastroenterology fellows are expected to obtain comprehensive training in the diagnosis and management of NGM disorders, there is ongoing concern for unmet training needs and lack of exposure in treating patients who suffer from NGM problems.

Study Design: We conducted a cross-section survey of trainees listed as pediatric gastroenterology fellows in North American training programs in 2018 via direct E-mail and the pediatric gastroenterology listserv. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002282DOI Listing
January 2019
5 Reads

A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia.

J Pediatr Gastroenterol Nutr 2019 Jan 17. Epub 2019 Jan 17.

Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO.

Objectives: Biliary atresia (BA) is a progressive neonatal fibroinflammatory cholangiopathy. We hypothesized that intravenous immunoglobulin (IVIg) would be safe, feasible, acceptable and efficacious for the treatment of BA. The primary objective of this study was to establish the feasibility, acceptability and safety profile of IVIg administration after hepatoportoenterostomy (HPE) in BA. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002256DOI Listing
January 2019
1 Read

Clinical and Endoscopy Findings in Children with Accidental Exposure to Concentrated Detergent Pods.

J Pediatr Gastroenterol Nutr 2019 Jan 16. Epub 2019 Jan 16.

Department of Pediatrics, Division of Pediatric Gastroenterology & Nutrition.

Background: Caustic ingestion with concentrated detergent pods (CDPs) is a common problem encountered in pediatric population. There is insufficient literature about endoscopic findings in CDP ingestion and hence no current consensus or guidelines regarding the need for endoscopic evaluation.

Objectives: To review cases of children with exposure to CDPs from 2010-2016 at a tertiary care children's hospital and to identifying the possibility of a correlation between clinical presentation and the endoscopic findings. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002270DOI Listing
January 2019
4 Reads

Impact of Immunosuppression On Executive Functioning After Pediatric Liver Transplantation: An Observational Cohort Study.

J Pediatr Gastroenterol Nutr 2019 Jan 16. Epub 2019 Jan 16.

Paediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany.

Objectives: Children after liver transplantation (LTx) show increased rates of impaired cognitive functioning. We aimed to assess the potential effects of immunosuppressive therapy on executive functioning measured by the Children's Colour Trail Test (CCTT) and the cognitive functioning module of the PedsQL (cogPedsQL) in liver transplanted children in order to explore potential targets for intervention to improve executive functioning.

Methods: We performed a cross-sectional study in 155 children (78 female) aged 10. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002274DOI Listing
January 2019
1 Read

Docosahexaenoic Acid in Mature Breast Milk of Low-Income Mothers.

J Pediatr Gastroenterol Nutr 2019 Jan 16. Epub 2019 Jan 16.

IDIP - Instituto de Desarrollo e Investigaciones Pediátricas "Prof. Dr. Fernando E. Viteri", Hospital de Niños "Sor María Ludovica" de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Argentina.

Docosahexaenoic acid (DHA) is among the main components of synaptosomal membranes and myelin sheaths. Since DHA is essential for child neurodevelopment, breast milk DHA levels should be improved by optimizing maternal nutrition. We determined DHA percentage levels in breast milk of low-income mothers receiving care at the public healthcare sector. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002284DOI Listing
January 2019
1 Read

Pediatric Endoscopy and High Risk Patients: A Clinical Report from the NASPGHAN Endoscopy Committee.

J Pediatr Gastroenterol Nutr 2019 Jan 16. Epub 2019 Jan 16.

Texas Children's Hospital, 1010 MW Tower, 6621 Fannin St, Houston, TX 77030.

Pediatric gastrointestinal endoscopy has been established as safe and effective for diagnosis and management of many pediatric gastrointestinal diseases. Nevertheless, certain patient and procedure factors should be recognized that increase the risk of intra and/or post procedural adverse events. Adverse events associated with endoscopic procedures can broadly be categorized as involving sedation-related physiological changes, bleeding, perforation and infection. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002277DOI Listing
January 2019
5 Reads

Fecal Fat Concentration and Excretion in the First 2 Years of Life: a Cross-Sectional Study.

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):285-289

Department of Pediatric Gastroenterology and Metabolic Diseases.

Objectives: Data on pancreatic exocrine secretion in the youngest children are scarce. The aim of the study was to determine the range of normal values for fecal fat concentration (FFC) and fecal fat excretion (FFE) in infants and toddlers up to 2 years of age.

Methods: A total of 160 subjects aged 1 to 24 months (8 groups of 20: aged 1-3, 4-6 months, etc) were included in the study. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002199DOI Listing
February 2019

Decreased Fecal Calprotectin Levels in Cystic Fibrosis Patients After Antibiotic Treatment for Respiratory Exacerbation.

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):282-284

Department of Pediatrics, Lady Davis Carmel Medical Center.

Objectives: In all patients with cystic fibrosis (CF), gastrointestinal (GI) tract CF transmembrane conductance regulator dysfunction occurs early in life. The identical pathophysiological triad of obstruction, infection, and inflammation causes disease of the airways and in the intestinal tract (CF enteropathy). Mucus accumulation within GI tract is a niche for abnormal microbial colonization, leading to dysbiosis. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002197DOI Listing
February 2019
4 Reads

Cardiovascular Risk Assessment in Pediatric Liver Transplant Patients.

J Pediatr Gastroenterol Nutr 2018 Oct 29. Epub 2018 Oct 29.

First Department of Pediatrics, Semmelweis University, Budapest, Hungary.

Objectives: Cardiovascular (CV) diseases play a leading role in the mortality of adult liver transplant (LT) recipients. However, data regarding CV risk factors in children after LT remain sparse. The present study assessed the presence of CV risk factors and signs of CV impairment in LT children. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002196DOI Listing
October 2018

Clinical Practice Approach to Nonalcoholic Fatty Liver Disease by Pediatric Gastroenterologists in the United States.

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):182-189

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla.

Objectives: Nonalcoholic fatty liver disease (NAFLD) is common; however, no information is available on how pediatric gastroenterologists in the United States manage NAFLD. Therefore, study objectives were to understand how pediatric gastroenterologists in the US approach the management of NAFLD, and to identify barriers to care for children with NAFLD.

Methods: We performed structured one-on-one interviews to ascertain each individual pediatric gastroenterologist's approach to the management of NAFLD in children. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002194DOI Listing
February 2019
3 Reads

Predictors of Long-Term Clinical and Endoscopic Remission in Children With Crohn's Disease Treated With Infliximab.

J Pediatr Gastroenterol Nutr 2019 Jan 8. Epub 2019 Jan 8.

Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome.

Objectives: We aimed to identify early non-invasive predictors of clinical and endoscopic remission in children with Crohn's disease (CD) under infliximab (IFX).

Methods: Prospective observational study conducted in children with moderate-to-severe CD starting IFX. All patients underwent weighted pediatric CD activity index (wPCDAI) assessment, C-reactive protein (CRP) and fecal calprotectin (FC) at week 0, 14 and 48. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002262DOI Listing
January 2019
8 Reads

Preterm Birth has Effects on Gut Colonization in Piglets Within the First 4 Weeks of Life.

J Pediatr Gastroenterol Nutr 2019 Jan 8. Epub 2019 Jan 8.

Department of Food Science, University of Copenhagen.

Objectives: Preterm neonates have an immature gastrointestinal tract and show an altered bacterial colonization of the gut. However, it is not clear if such immature gut microbiota (GM) colonization is induced by specific delivery, diet, environment and/or host factors related to preterm birth. Using piglets as models for infants, we hypothesized that both shortened gestational age (GA) and start of enteral feeding affect GM composition after caesarean delivery and rearing in identical environments. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002259DOI Listing
January 2019
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Adequate Infliximab Exposure During Induction Predicts Remission in Paediatric Patients With Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2019 Jan 8. Epub 2019 Jan 8.

TARGID, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.

Objectives: Therapeutic drug monitoring has been proposed as a useful tool in the management of infliximab (IFX) treated patients with inflammatory bowel disease (IBD). The aim of this retrospective study was to determine whether IFX trough levels after induction therapy are predictive for outcome at week 52.

Methods: All paediatric IBD patients receiving maintenance IFX at our centre, with IFX trough level available at their first maintenance infusion and a follow-up of at least 52 weeks were included. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002265DOI Listing
January 2019
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Long-term Outcomes of an Interdisciplinary Tube Weaning Program: A Quantitative Study.

J Pediatr Gastroenterol Nutr 2019 Jan 8. Epub 2019 Jan 8.

Medical University of Graz, Austria.

Background And Objectives: Children who become tube dependent need specialized treatment in order to make the transition to oral feeding. Little is known about long-term effects of tube weaning programs. This study analyses long-term effects (outcome, growth and nutrition data) in a large sample of formerly tube dependent children 1-6 years after participation in tube weaning programs, based on the "Graz model of tube weaning". Read More

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http://Insights.ovid.com/crossref?an=00005176-900000000-9657
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http://dx.doi.org/10.1097/MPG.0000000000002264DOI Listing
January 2019
5 Reads