10,050 results match your criteria Journal of Pediatric Gastroenterology and Nutrition[Journal]


Psychologic distress and anxiety in mothers of children with gastroesophageal reflux undergoing antireflux surgery.

J Pediatr Gastroenterol Nutr 2019 Apr 9. Epub 2019 Apr 9.

Institute of Clinical Medicine, University of Oslo, Norway.

Objectives: Parents of children with a chronic illness are at risk for impaired psychosocial functioning. Gastroesophageal reflux disease (GERD) is such a disease, and no studies have investigated effects of antireflux surgery on parental psychological distress. The aims of this study were to assess psychological distress and state and trait anxiety in mothers of children with GERD, and to explore possible changes after antireflux surgery. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002286DOI Listing

Substance Use in Adolescents and Young Adults with Inflammatory Bowel Diseases: An Exploratory Cluster Analysis.

J Pediatr Gastroenterol Nutr 2019 Apr 9. Epub 2019 Apr 9.

Rosalind Franklin University of Medicine and Science.

Objectives: Adolescents and young adults (AYAs) with chronic illnesses use substances at similar, if not greater, rates compared to healthy peers. The present study aimed to examine rates and patterns of tobacco use, marijuana use, and binge drinking in AYAs with inflammatory bowel diseases (IBD). We expected that substance use would be associated with poorer physical health, psychosocial functioning, and disease management. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002365DOI Listing
April 2019
1 Read

Orbezoar: A Superabsorbent Polymer Causing Small Bowel Obstruction in a Toddler.

J Pediatr Gastroenterol Nutr 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/MPG.0000000000002357DOI Listing

Differential Intraoperative Effect of Liver Transplant in Different Inborn Errors of Metabolism.

J Pediatr Gastroenterol Nutr 2019 Apr 1. Epub 2019 Apr 1.

Department of Pediatrics, University of Torino.

Liver transplant (LT) is a therapeutic option for a growing number of inborn errors of metabolism (IEM), including some disorders not confined to the liver. Clinical advantages of LT in maple syrup urine disease (MSUD), methylmalonic acidemia (MMA), and argininosuccinic aciduria (ASA) have been reported. However, no information on the early metabolic effect of LT after portal reperfusion is available in these disorders. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002354DOI Listing
April 2019
1 Read

Paediatric Endoscopy Global Rating Scale: Development of a Quality Improvement Tool and Results of a National Pilot.

J Pediatr Gastroenterol Nutr 2019 Apr 1. Epub 2019 Apr 1.

Joint Advisory Group, Royal College of Physicians, London.

Introduction And Objectives: The endoscopy Global Rating Scale (GRS) is a web-based self-assessment quality improvement (QI) tool that provides a framework for service improvement. Widespread use of the GRS in adult endoscopy services in the United Kingdom (UK) has led to a demonstrable improvement in quality. The adult GRS is not directly applicable to paediatric endoscopy services. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002355DOI Listing
April 2019
2.625 Impact Factor

Randomized Controlled Trial of Oropharyngeal Colostrum Administration in Very-low-birth-weight Preterm Infants.

J Pediatr Gastroenterol Nutr 2019 Apr 1. Epub 2019 Apr 1.

Division of Neonatology, Department of Pediatrics.

Objective: The purpose of this study was to evaluate the effects of oropharyngeal colostrum administration in the incidence of late-onset clinical and proven sepsis and in concentrations of immunoglobulin A (IgA) in very-low-birth-weight (VLBW) infants.

Methods: We conducted a double-blinded, randomized, placebo-controlled trial and assigned 113 VLBW infants to receive 0.2 mL of maternal colostrum or sterile water (placebo) via oropharyngeal route every 2 hours for 48 hours, beginning in the first 48 to 72 hours of life. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002356DOI Listing

Inflammatory Bowel Disease Serological Immune Markers Anti-Saccharomyces cerevisiae Mannan Antibodies and Outer Membrane Porin C are Potential Biomarkers for Hirschsprung-associated Enterocolitis.

J Pediatr Gastroenterol Nutr 2019 Apr 1. Epub 2019 Apr 1.

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.

Objective: Hirschsprung-associated enterocolitis (HAEC) is the most frequent complication in Hirschsprung disease (HSCR) patients. Currently HAEC is diagnosed clinically, leaving uncertainty in the diagnosis thereby potentially leading to over- or undertreatment of patients. The aim of this study was to identify immune biomarkers to aid in the diagnosis of HAEC. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002358DOI Listing
April 2019
2 Reads

A Path to Consensus on Endoscopic Pancreatic Function Testing.

Authors:
Daniel Gelfond

J Pediatr Gastroenterol Nutr 2019 Apr 1. Epub 2019 Apr 1.

WNY Pediatric Gastroenterology, PLLC, 166 Washington Avenue, Batavia, NY 14221, University of Buffalo School of Medicine, DGRD, LLC.

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http://dx.doi.org/10.1097/MPG.0000000000002359DOI Listing

improving IBD Transition, Self-management, and Disease Outcomes With an In-clinic Transition Coordinator.

J Pediatr Gastroenterol Nutr 2019 Apr 1. Epub 2019 Apr 1.

Cincinnati Children's Hospital Medical Center, Schubert-Martin Pediatric IBD Center.

Objectives: Deficits in the preparation of patients with inflammatory bowel disease (IBD) who are transitioning to adult care are known yet studies presenting outcome data of transition interventions in IBD are lacking. We present data evaluating the impact of a transition coordinator on behavioral and clinical transition outcomes.

Methods: A retrospective chart review identified 135 patients who had met with our transition coordinator and completed the Transition Readiness Assessment Questionnaire before, and 1 year after, the intervention. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002350DOI Listing
April 2019
1 Read

Infliximab paradoxical psoriasis in a cohort of children with inflammatory bowel disease.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Paris France.

Objectives: In adult inflammatory bowel disease (IBD) treated by anti-TNF antibodies, paradoxical psoriasis has an estimated prevalence of 1.6 to 22%, especially in infliximab (IFX)-treated patients. Little is known in the pediatric IBD (PIBD) populations. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002349DOI Listing
March 2019
1 Read

Hepatic Venous Pressure Gradient Measurements in Children: Correlation With Hepatic Histology and Clinical Indicators of Portal Hypertension.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Center for Clinical and Translational Research, Seattle Children's Research Institute.

Objectives: In adults, elevated hepatic venous pressure gradients (HVPGs) are correlated with the degree of liver fibrosis on histopathology and predict worse outcomes including variceal bleeding and death. We aimed to examine the association between HVPG measurements, histopathologic findings, and clinical indicators of portal hypertension in children.

Methods: Utilizing retrospective data from 2 pediatric centers between 2006 and 2015, we identified children who underwent simultaneous HVPG measurement and transjugular liver biopsy. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002327DOI Listing
March 2019
2 Reads

Pediatric Celiac Disease and Eosinophilic Esophagitis: Outcome of Dietary Therapy.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Comer Children's Hospital, University of Chicago Medical Center, Chicago, Illinois.

Objective: The coexistence of celiac disease (CeD) and eosinophilic esophagitis (EoE) in pediatric patients has been increasingly recognized. In the current study, we have aimed to assess the outcomes of therapeutic dietary interventions in a cohort of pediatric patients with CeD and EoE.

Methods: Pediatric patient records obtained from the University of Chicago Celiac Center Database from August 2008 to July 2013 were reviewed. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002343DOI Listing
March 2019
2 Reads

A Symptom Self-report Tool for Children With Inflammatory Bowel Disease (IBDnow).

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Department of Paediatrics, Otago University, Otago, New Zealand.

Objectives: Clinical symptom evaluation for children with inflammatory bowel disease (IBD) is typically done using composite tools: the Pediatric Crohn's Disease Activity Index (PCDAI) and Pediatric Ulcerative Colitis Activity Index (PUCAI). Both rely on clinician interpretation of child or parent symptom recall. No universal self-report tool has yet been developed for children with IBD to assess and report their symptoms. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002329DOI Listing
March 2019
1 Read

Sensitivity and Specificity of Administrative Medical Coding for Pediatric Eosinophilic Esophagitis.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Division of Pediatric Gastroenterology, Department of Pediatrics, University of Utah.

Objectives: Eosinophilic esophagitis (EoE) is a delayed-type hypersensitivity with increasing rates among pediatric populations. Although studies have used International Classification of Diseases (ICD) coding to define local cohorts and report disease epidemiology, the accuracy of the EoE ICD code for pediatric EoE is unknown.

Methods: We searched the Intermountain Healthcare Database for pediatric cases with the EoE ICD code over a 5-year period. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002340DOI Listing
March 2019
3 Reads

A Unified Treatment Algorithm and Admission Order Set for Pediatric Acute Pancreatitis.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Department of Pediatrics, University of Cincinnati College of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1097/MPG.0000000000002341DOI Listing

Development of a Patient Reported Experience and Outcomes Measure in Pediatric Patients Undergoing Bowel Management for Constipation and Fecal Incontinence.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Center for Surgical Outcomes Research, Center for Innovation in Pediatric Practice, The Research Institute and Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio.

Aims And Objectives: To develop a reliable and valid questionnaire that assesses patient reported experience (PREMs) and patient reported outcome measures (PROMs) of caregivers, families, and patients with severe constipation and fecal incontinence who failed conservative treatments and require a formal bowel management program (BMP).

Methods: A five step iterative process was utilized to ensure the reliability and validity of the final instrument. Parents or guardians of patients undergoing our week-long BMP were first asked 20 open-ended questions aimed at understanding the challenges in managing their child's condition. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002348DOI Listing
March 2019
1 Read

Incontinence in Phelan-McDermid Syndrome.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, 20892, USA.

Objective: To evaluate gastrointestinal symptoms and continence in the context of Phelan-McDermid Syndrome (PMS).

Study Design: A prospective evaluation of children with PMS (n = 17) at the National Institutes of Health.

Results: Parent-reported history of symptoms were common: constipation (65%), reflux (59%), choking/gagging (41%), and more than half received gastrointestinal specialty care. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002342DOI Listing
March 2019
1 Read

Esophagitis in Pediatric Esophageal Atresia: Acid May Not Always Be the Issue.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Division of Gastroenterology, Hepatology and Nutrition.

Objective: Esophagitis is highly prevalent in patients with esophageal atresia (EA). Peptic esophagitis has long been assumed to be the primary cause of esophagitis in this population, and prolonged acid suppressive medication usage is common; such treatment is of unknown benefit and carries potential risk.

Methods: To better understand the role of commonly used antireflux treatments in EA, we analyzed all patients with repaired EA who underwent endoscopy with biopsies at our institution between January 2016 and August 2018. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002336DOI Listing
March 2019
1 Read

Pancreatoscopy-Directed Electrohydraulic Lithotripsy in a Pediatric Patient with Pancreas Divisum and Cystic Fibrosis.

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine.

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http://dx.doi.org/10.1097/MPG.0000000000002347DOI Listing
March 2019
1 Read

Sedation and The FDA Warning: What a Pediatric Gastroenterologist, Hepatologist and Pancreatologist Should Know.

J Pediatr Gastroenterol Nutr 2019 03 26. Epub 2019 Mar 26.

University of Massachusetts School of Medicine, Department of Pediatrics; Umass Memorial Children’s Medical Center, Division of Pediatric Gastroenterology and Nutrition

Pediatric gastroenterologists recommend and perform a range of procedures requiring sedation and anesthesia in young children. A recent warning from the US FDA states that "repeated or lengthy use of general anesthetics and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women during their third trimester may affect the development of children's brains.' 1 As it relates to time, the FDA warning details risks of 'procedures lasting longer than 3 hours or if multiple procedures are required. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002346DOI Listing

The Accuracy of a Home Performed Faecal Calprotectin Test in Paediatric Patients With Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2019 Mar 18. Epub 2019 Mar 18.

Department of Paediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.

Objectives: Owing to the invasiveness of endoscopy, the use of biomarkers, especially faecal calprotectin (FC), has become standard for remission assessment. This study aimed to compare the accuracy for detection of endoscopic activity using recently developed FC home test using smartphone application (FC-IBDoc) against standard enzyme-linked immunosorbent assay (ELISA).

Methods: In all, 102 consecutive observations (89 participants) were included in prospective observational study. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002331DOI Listing
March 2019
5 Reads
2.625 Impact Factor

Resting Energy Expenditure of Children with End Stage Chronic Liver Disease Before and After Liver Transplantation.

J Pediatr Gastroenterol Nutr 2019 Mar 18. Epub 2019 Mar 18.

King's College Hospital NHS Foundation Trust and MowatLabs, London, UK.

Objectives: Our objective was to test the hypothesis that children with end stage chronic liver disease (ESCLD) are hypermetabolic when compared to healthy children, and that this hypermetabolism persists for at least 6 months after liver transplant.

Methods: 17 patients with ESCLD and 14 healthy controls had their resting energy expenditure measured (mREE) by indirect calorimetry. Weight, height and BMI was converted to standard deviation (sd) scores. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002344DOI Listing

Letter to the Editor Re: Serum calprotectin in adolescents with Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2019 Mar 18. Epub 2019 Mar 18.

School of Women's and Children's Health, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1097/MPG.0000000000002345DOI Listing
March 2019
2 Reads

Partial Splenic Embolization is a Safe and Effective Alternative in the Management of Portal Hypertension in Children.

J Pediatr Gastroenterol Nutr 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatrics, Columbia University Medical Center, New York, NY.

Objective: There are multiple approaches to manage the clinical complications of portal hypertension (PHTN) to treat/prevent spontaneous hemorrhage by mitigating thrombocytopenia. No single approach is ideal for all patients given the heterogeneity of this population. Our goal was to determine whether partial splenic embolization (PSE) was safe and effective in the pediatric population. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002332DOI Listing
March 2019
5 Reads

Variables Impacting the Time Taken to Wean Children from Enteral Tube Feeding to Oral Intake.

J Pediatr Gastroenterol Nutr 2019 Mar 18. Epub 2019 Mar 18.

Faculty of Health Sciences, The University of Sydney.

Objectives: This study investigated biological factors which may influence the time taken for children to wean from enteral to oral intake.

Methods: Retrospective case-note audit of 62 tube fed children (nasogastric (NG) or percutaneous endoscopic gastrostomy (PEG)) aged 6 months to 8 years, participating in an intensive tube weaning program. Program design included family focused mealtimes, child autonomy and appetite stimulation. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002330DOI Listing
March 2019
6 Reads

External Generalizability of Clinical Trials to Developing Countries.

Authors:
David R Brewster

J Pediatr Gastroenterol Nutr 2019 Mar 18. Epub 2019 Mar 18.

Pediatric Department, National Hospital Guido Valadares, National University of Timor Lorosae, Dili, Timor-Leste.

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http://dx.doi.org/10.1097/MPG.0000000000002334DOI Listing

Pediatric Non-Celiac Gluten Sensitivity: A Gluten-Related Disorder Treatment Center Experience.

J Pediatr Gastroenterol Nutr 2019 Mar 18. Epub 2019 Mar 18.

Center for Celiac Research and Treatment, Pediatric Gastroenterology and Nutrition, Mass General Hospital for Children, Boston, MA.

Objective: To identify the prevalence and clinical characteristics of children with non-celiac gluten sensitivity (NCGS) presenting to a tertiary care center specialized for evaluation of gluten-related disorders.

Methods: The medical records of all patients aged 0-18 years who presented to our center over a 4-year period (July 2013-June 2018) and consented to participate in our research registry were reviewed. Patients meeting the clinical criteria for NCGS were reviewed in detail. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002335DOI Listing
March 2019
3 Reads

Clinically Evident Portal Hypertension: An Operational Research Definition for Future Investigations in the Pediatric Population.

J Pediatr Gastroenterol Nutr 2019 Mar 18. Epub 2019 Mar 18.

Surgery, University of Michigan, Ann Arbor, MI.

Portal Hypertension (PHT) is a major cause of morbidity and mortality in pediatric liver diseases. Thus, research into causes and disease modifiers in PHT in these conditions is vitally important. PHT is rarely directly or indirectly measured in the assessment of children with chronic liver disease. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002333DOI Listing
March 2019
3 Reads

Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):566-573

Department of Medicine.

Objectives: The aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.

Methods: Demographics, risk factors, disease duration, management and outcomes of 224 children and 1063 adults were compared using appropriate statistical tests for categorical and continuous variables.

Results: Alcohol was a risk in 53% of adults and 1% of children (P < 0. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002279DOI Listing
April 2019
2.625 Impact Factor

Experience of Using a Semielemental Formula for Home Enteral Nutrition in Children: A Multicenter Cross-sectional Study.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):585-590

Department of Pediatric Gastroenterology, Hepatology and Nutrition, CHU Lille, University Lille, Lille, France.

Objectives: The use of semielemental diets concerns a small proportion of children on enteral nutrition whose characteristics have never been reported. Our aim was to describe a cohort of patients on home enteral nutrition with Peptamen Junior, including the tolerance and nutritional efficacy of this product.

Methods: We performed a retrospective multicenter survey on a cohort of patients receiving this semielemental diet at home between 2010 and 2015 in 14 tertiary pediatric French centers. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002236DOI Listing
April 2019
1 Read

Mediators in Preterm Infants With Late-onset Sepsis: A Randomized Controlled Trial.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):578-584

Department of Neonatology, Cleveland Clinic Children's Hospital, Cleveland, OH.

Objective: To evaluate biochemical and clinical effects of 2 different doses of vitamin D supplementation in preterm infants with late-onset sepsis (LOS).

Study Design: A double blinded randomized controlled stratified trial included preterm infants with gestational age (GA) ≥28 weeks with LOS. Subjects were randomly assigned to receive 400 or 800 IU/day of vitamin D3. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002238DOI Listing
April 2019
3 Reads
2.625 Impact Factor

Colombian School Children With Functional Gastrointestinal Disorders Respond Differently to Family Stress Than Healthy Children.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):e58-e61

Division of Gastroenterology, Hepatology, and Nutrition, University of Miami, Miller School of Medicine, Miami, FL.

Our objective is to compare coping methods, stress responses, and resilience in children with and without functional gastrointestinal disorders (FGIDs) in response to common sources of stress. We performed a case-control study. Children meeting criteria for FGIDs and matched controls completed measures of response to stress (Peer Stress, Family Stress, Academic Problems, and Recurrent Abdominal Pain versions of the Response to Stress Questionnaire) and resilience (Connor-Davidson Resilience Scale 10). Read More

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http://dx.doi.org/10.1097/MPG.0000000000002219DOI Listing
April 2019
1 Read

Treating Biliary Atresia: The Challenge Continues.

J Pediatr Gastroenterol Nutr 2019 Apr;68(4):464-465

Department of Pediatrics.

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http://dx.doi.org/10.1097/MPG.0000000000002302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430144PMC

Characterization of Esophageal Motility in Infants with Congenital Diaphragmatic Hernia using High Resolution Manometry.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

Department of Neurosciences, Experimental Oto-Rhino-Laryngology, Deglutology, KU Leuven, Belgium.

Objectives: To characterize esophageal motility and esophago-gastric junction (EGJ) function in infants who underwent repair of an isolated congenital diaphragmatic hernia (iCDH).

Methods: High Resolution Manometry with impedance was used to investigate esophageal motility and EGJ function after diaphragmatic repair in 12 infants with iCDH (11 left-sided; 9 patch repair). They had esophageal motility studies during neonatal admission (n = 12), at 6 months (n = 10) and at 12 months of life (n = 7). Read More

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http://dx.doi.org/10.1097/MPG.0000000000002325DOI Listing
March 2019
1 Read

Horizontal Transmission of Hepatitis B Virus From Mother to Child Due to Immune Escape Despite Immunoprophylaxis.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba.

Hepatitis B virus (HBV) vaccination starting at birth is approximately 95% effective in preventing mother-to-child transmission to infants born to HBV-infected mothers. A higher risk of transmission is associated with birth to a highly viremic mother, often due to transplacental exposure, while later horizontal transmission is much less common, particularly following complete vaccination. This study reports a case of infection in an older child despite appropriate immunoprophylaxis starting at birth and an apparent protective immune response post-vaccination. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002318DOI Listing
March 2019
1 Read

MR Imaging: A Personalized approach to understanding fatty liver disease.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

Feinberg School of Medicine at Northwestern University.

Objectives: To assess information retention by parents/caretakers regarding nonalcoholic fatty liver disease (NAFLD) utilizing the actual image of their child's affected liver.

Methods: In this pilot study, parents/caretakers of children with newly-diagnosed NAFLD were presented with an MR image of their child's fatty liver. An adjacent image of a normal-appearing liver was used to highlight the degree of fat accumulation present in their child's liver. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002316DOI Listing
March 2019
4 Reads

Mixed lipid, fish oil and soybean oil parenteral lipids impact cholestasis, hepatic phytosterol and lipid composition.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

Department of Pediatric Gastroenterology and Nutrition, University of Alberta, Alberta, Edmonton, Canada.

Objectives: In parenteral nutrition dependent infants and children, intestinal failure (IF) associated liver disease (IFALD) remains an important problem. A comparative study was undertaken of parenteral mixed lipid (ML), ω-3 predominant fish oil (FO), and ω-6 predominant soybean oil (SO) emulsions in regards to hepatic phytosterol, neutral lipid, fatty acid (FA) content and the relationship to cholestasis in piglets.

Methods: Neonatal piglets received parenteral nutrition, varying in lipid dose (5 or 10 g/kg/d) and formulation: SO5 (n = 5), SO10 (n = 5), FO5 (n = 5) and ML10 (n = 5). Read More

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http://dx.doi.org/10.1097/MPG.0000000000002313DOI Listing
March 2019
3 Reads

Energy Balance in Critically Ill Children With Severe Sepsis Using Indirect Calorimetry: A Prospective Cohort Study.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

Division of Pediatric Biochemistry, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Objectives: Energy needs in critically ill children are dynamic and variable. Data on energy balance in children with severe sepsis using indirect calorimetry (IC) is lacking. Thus, we planned to study the energy needs and balance of this cohort. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002314DOI Listing
March 2019
7 Reads

Paediatric Colonoscopy Direct Observation of Procedural Skills (DOPS): Evidence of Validity and Competency Development.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

Department of Paediatric Gastroenterology, Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, UK.

Introduction: The paediatric series of direct observation of procedural skills (DOPS) were introduced into the UK national endoscopy training curriculum in 2016, but lack validity evidence. We aimed to present validity evidence for paediatric colonoscopy DOPS and study competency development in a national trainee cohort.

Methods: This prospective UK-wide study analysed formative paediatric colonoscopy DOPS which were submitted to the e-Portfolio between 2016 and 2018. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002321DOI Listing
March 2019
5 Reads

Normal Liver Stiffness Values in Children - A Comparison of Three Different Elastography Methods.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Objectives: Noninvasive tests for the evaluation of liver fibrosis are particularly helpful in children to avoid general anesthesia and potential complications of invasive tests. We aimed to establish reference values for two different elastography methods in a head-to-head-comparison for children and adolescents 4-17 years, using transient elastography as common reference in a subset.

Methods: 243 healthy participants aged 4-17 years were examined by a single observer with a full liver B-mode scan prior to elastography, following a minimum of 3 hours fasting. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002320DOI Listing

Should Proton Pump Inhibitors be Systematically Prescribed in Patients with Esophageal Atresia After Surgical Repair?

J Pediatr Gastroenterol Nutr 2019 03 5. Epub 2019 Mar 5.

Division of Pediatric Gastroenterology Hepatology and Nutrition, CHU Sainte-Justine, Université de Montréal, Montréal, Canada.

Objective: To evaluate outcomes of patients with esophageal atresia (EA) on systematic treatment with proton pump inhibitors (PPI) since the neonatal period and to determine factors associated with successful discontinuation of PPI.

Study Design: Longitudinal cohort study with prospective data collection of 73 EA patients, over 11 years systematically treated with PPI. Outcome and predictive factors for discontinuation of PPI treatment were evaluated at study end in February 2017. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002328DOI Listing

Sub-10 Minute High Quality Diagnostic Colonoscopy with Terminal Ileum Intubation in Children is Feasible and Safe.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

Department of Paediatrics, Sapienza University of Rome, Rome, Italy.

Objectives: To critically appraise ileocolonoscopy practice in a large tertiary center, where ileocolonoscopy is exclusively performed by experienced pediatric colonoscopists, particularly focusing on: indications for the procedure; bowel preparation efficacy; IC completion rates and timings; diagnostic yield; and complications.

Patients And Methods: We prospectively evaluated all patients referred to our clinic between July 2015 and June 2016. Data on age, height and weight, gender, surgical history, indications for colonoscopy, bowel preparation given, bowel cleansing efficacy were collected. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002326DOI Listing
March 2019
2 Reads

Pediatric Colonoscopy Quality Indicators: Teamwork and Transparency.

J Pediatr Gastroenterol Nutr 2019 Feb 20. Epub 2019 Feb 20.

Division of Gastroenterology, Hepatology and Nutrition, The Reseach and Learning Institutes, Hospital for Sick Children.

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http://dx.doi.org/10.1097/MPG.0000000000002324DOI Listing
February 2019
2.625 Impact Factor

Avoidant/Restrictive Food Intake Disorder in Diet-Treated Children with Eosinophilic Esophagitis.

J Pediatr Gastroenterol Nutr 2019 Feb 20. Epub 2019 Feb 20.

Food Allergy and Eosinophilic Gastrointestinal Disorders Clinic, Department of Pediatrics, Division of Pediatric Psychiatry and Behavioral Health, University of Utah, Primary Children's Hospital, Salt Lake City, UT.

Eosinophilic esophagitis (EoE) is an inflammatory condition of the esophagus with rising incidence in children. Owed to potential adverse effects and high costs of EoE medications, strict elimination diets are often employed as a mainstay of long-term EoE therapy in children. Currently, there are no effective tests to pinpoint food protein triggers in children with EoE. Read More

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http://Insights.ovid.com/crossref?an=00005176-900000000-9651
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http://dx.doi.org/10.1097/MPG.0000000000002323DOI Listing
February 2019
6 Reads

Efficacy of Vedolizumab for Inflammatory Bowel Disease in the Setting of DiGeorge Syndrome.

J Pediatr Gastroenterol Nutr 2019 Feb 20. Epub 2019 Feb 20.

Section of Gastroenterology, Hepatology and Nutrition, St. Christopher's Hospital for Children, Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1097/MPG.0000000000002322DOI Listing
February 2019
1 Read

Disseminated Gastro-Intestinal and Hepatosplenic EBV-Related Smooth Muscle Tumors in a Young Heart-Transplant Recipient.

J Pediatr Gastroenterol Nutr 2019 Feb 20. Epub 2019 Feb 20.

Bone Marrow Transplant Unit, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.

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http://dx.doi.org/10.1097/MPG.0000000000002315DOI Listing
February 2019

Isolated Amylase Deficiency in Children and its Clinical Implication.

J Pediatr Gastroenterol Nutr 2019 Feb 20. Epub 2019 Feb 20.

Clinical Professor of Pediatrics, The Florida State University, Center for Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL.

Objectives And Study: Among the three lines of pancreatic enzymes, amylase secretion develops last and it is not detected in duodenal aspirates of infants in the first month after birth. The aim of this study was to assess the prevalence and symptoms of isolated amylase deficiency in children.

Methods: During a 6-year period we performed endoscopic pancreatic function tests (ePFT) in 712 children. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002317DOI Listing
February 2019
1 Read

Retrograde balloon Enteroscopy for diagnosis of Meckel's Diverticulum.

J Pediatr Gastroenterol Nutr 2019 Feb 20. Epub 2019 Feb 20.

Nicklaus Children's Hospital, Miami, Florida United States.

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http://dx.doi.org/10.1097/MPG.0000000000002319DOI Listing
February 2019

Gallbladder Polyps: Rare Lesions in Childhood.

J Pediatr Gastroenterol Nutr 2019 Feb 20. Epub 2019 Feb 20.

Ondokuz Mayıs University Faculty of Medicine, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Samsun, Turkey.

Objective: Unlike adults, gallbladder polyps (GPs) are rare in childhood. The aim of this study was to evaluate patients with a GP diagnosis.

Methods: Patients who were diagnosed with GP via ultrasonography from October 2012 - October 2017 were retrospectively evaluated in terms of socio-demographic characteristics, laboratory findings. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002269DOI Listing
February 2019
1 Read

Sarcina Ventriculi in a patient with repaired Esophageal Atresia: a benign commensal?

J Pediatr Gastroenterol Nutr 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastroenterology, Sydney Children's Hospital, Randwick, Sydney.

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http://dx.doi.org/10.1097/MPG.0000000000002339DOI Listing