1,237 results match your criteria Journal of Pain Research [Journal]


Effect of ketorolac in intra-articular injection analgesia for postoperative pain in patients undergoing shoulder arthroscopy: a pilot-controlled clinical study.

J Pain Res 2019 17;12:417-422. Epub 2019 Jan 17.

Department of Orthopaedics, Changzhou Traditional Chinese Medical Hospital, Changzhou, Jiangsu 213003, China,

Background: To date, a regional approach using local anesthetics has become a popular analgesic method for arthroscopy. The optimal postoperative analgesia method for shoulder arthroscopy is still debated.

Objective: This study was designed to evaluate the effect and safety of using ketorolac in combination with a multimodal drug regime (ropivacaine, morphine, and triamcinolone acetonide) after shoulder arthroscopy. Read More

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http://dx.doi.org/10.2147/JPR.S178413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342218PMC
January 2019

Contribution of GABAergic modulation in DRGs to electroacupuncture analgesia in incisional neck pain rats.

J Pain Res 2019 17;12:405-416. Epub 2019 Jan 17.

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China,

Purpose: Acupuncture therapy is effective for relieving postoperative pain. Our previous study showed that electroacupuncture (EA) at Futu (LI18) and Hegu (LI4)-Neiguan (PC6) could alleviate incisional neck pain, which was related with its effect in upregulating γ-aminobutyric acid (GABA) expression in cervical (C3-6) dorsal root ganglions (DRGs); but whether its receptor subsets GABAα2R and GABAR1 in C3-6 DRGs are involved in EA analgesia or not, it remains unknown.

Materials And Methods: Seventy-five male Sprague Dawley rats were randomized to normal control, model, LI18, LI4-PC6, and Zusanli (ST36)-Yanglingquan (GB34) groups. Read More

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https://www.dovepress.com/contribution-of-gabaergic-modulati
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http://dx.doi.org/10.2147/JPR.S180165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342219PMC
January 2019
3 Reads

Development and preliminary evaluation of a short self-report measure of generalized pain hypersensitivity.

J Pain Res 2019 17;12:395-404. Epub 2019 Jan 17.

Department of Rheumatology, Medisch Spectrum Twente, Enschede, Netherlands.

Purpose: Generalized pain hypersensitivity is frequently observed in chronic pain conditions. Currently, identification is based on expert clinical opinion, and in very few cases combined with quantitative sensory testing. The objectives of this study were to develop and evaluate a short self-report measure of generalized pain hypersensitivity: a generalized pain questionnaire (GPQ). Read More

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http://dx.doi.org/10.2147/JPR.S182287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342225PMC
January 2019
1 Read

Effects of extracorporeal shock waves on neuralgia in diabetic rats.

J Pain Res 2019 17;12:387-394. Epub 2019 Jan 17.

Department of Pain, Guizhou Provincial People's Hospital, Guiyang 550002, China,

Objective: The aim of this study was to observe the effects of extracorporeal shock waves (ECSWs) on neuralgia in diabetic rats.

Materials And Methods: Diabetic neuralgia model was established in rats via injection of streptozotocin. The rats were divided into diabetic neuralgia group (Group A, n=6) and ECSW treatment group (Group B, n=6). Read More

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http://dx.doi.org/10.2147/JPR.S177585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342217PMC
January 2019

Effects of low-dose ketamine infusion on remifentanil-induced acute opioid tolerance and the inflammatory response in patients undergoing orthognathic surgery.

J Pain Res 2019 17;12:377-385. Epub 2019 Jan 17.

Department of Dental Anesthesiology and Pain Management, Tohoku University Hospital, Sendai, Miyagi, Japan,

Purpose: Remifentanil is associated with acute opioid tolerance that can lead to increased postoperative consumption of opioid analgesics. The purpose of this study was to determine whether a low dose of ketamine prevents remifentanil-induced acute opioid tolerance and affects the neutrophil-lymphocyte ratio (NLR), a newly recognized biomarker of inflammation.

Materials And Methods: Forty patients undergoing orthognathic surgery were enrolled in this prospective, randomized, double-blind study and randomly assigned to intraoperative administration of one of the following anesthetic regimens: high-dose remifentanil (0. Read More

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http://dx.doi.org/10.2147/JPR.S177098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342226PMC
January 2019

Efficacy and safety of controlled-release oxycodone for the management of moderate-to-severe chronic low back pain in Japan: results of an enriched enrollment randomized withdrawal study followed by an open-label extension study.

J Pain Res 2019 17;12:363-375. Epub 2019 Jan 17.

Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.

Background: Oxycodone is one of the options for the management of CLBP in patients with an inadequate response to other analgesics. However, oxycodone is not yet approved for noncancer pain in Japan. Here, we assessed the efficacy and long-term safety of S-8117, a controlled-release oxycodone formulation, for the management of Japanese CLBP patients. Read More

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http://dx.doi.org/10.2147/JPR.S179110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342210PMC
January 2019

Therapeutic efficacy and safety of radiofrequency ablation for the treatment of trigeminal neuralgia: a systematic review and meta-analysis.

J Pain Res 2019 18;12:423-441. Epub 2019 Jan 18.

Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, Nantong 226001, People's Republic of China,

Objective: The objective of this study was to summarize the effectiveness and safety of trigeminal neuralgia (TN) treatment via different radiofrequency approaches such as continuous radiofrequency (CRF), pulsed radiofrequency (PRF), and combined CRF and pulsed radiofrequency (CCPRF) treatments, thus providing high-quality clinical evidence for TN treatment.

Methods: A series of databases were searched for relevant articles published between January 1998 and April 2018. The modified Jadad scale was referred to evaluate the methodological quality of the included studies. Read More

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http://dx.doi.org/10.2147/JPR.S176960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342144PMC
January 2019
5 Reads

Patients' return-to-work expectancy relates to their beliefs about their physician's opinion regarding return to work volition and ability.

J Pain Res 2019 15;12:353-362. Epub 2019 Jan 15.

Department of Psychology, Gothenburg University, Gothenburg, Sweden.

Purpose: This study investigates the relationship between sick-listed patients' return to work (RTW) expectancy and how they perceive that their physicians evaluate their ability and volition for RTW.

Methods: Hierarchical logistic regression controlling for sociodemographic factors and pain characteristics was carried out on cross-sectional data from 205 participants (mean age= 47.24±9. Read More

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http://dx.doi.org/10.2147/JPR.S179061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339447PMC
January 2019

Ethical justification of single-blind and double-blind placebo-controlled response tests in neuropathic pain and N-of-1 treatment paradigm in clinical settings.

J Pain Res 2019 14;12:345-352. Epub 2019 Jan 14.

Pain Management Centre, Charing Cross Hospital Imperial Healthcare NHS Trust, London, UK.

At our center in the Netherlands, patients, who very often are treatment resistant to the analgesics recommended in the guidelines, suffering from symmetrical peripheral neuropathic pain are treated exclusively. We have developed a number of compounded topical formulations containing classical co-analgesics such as ketamine, baclofen, amitriptyline, and phenytoin for the treatment of neuropathic pain in treatment-resistant patients. In order to identify putative responders and exclude an (initial) placebo-response, we developed single-blind and double-blind placebo-controlled response tests. Read More

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http://dx.doi.org/10.2147/JPR.S180792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338124PMC
January 2019

Activating transcription factor 3 modulates protein kinase C epsilon activation in diabetic peripheral neuropathy.

J Pain Res 2019 14;12:317-326. Epub 2019 Jan 14.

Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan,

Background: Skin denervation that develops in patients with diabetes mellitus as a neuropathic manifestation is known as diabetic peripheral neuropathy (DPN). Skin denervation is parallel to neuronal injuries that alter intracellular signaling. To date, the correlation between nerve injury and the activation of intracellular responses to neuropathic manifestations has not been elucidated; specifically, whether activating transcription factor 3 (ATF3) is responsible for neuronal injury and a critical molecule that modulates the activation of intracellular protein kinase C epsilon (p-PKCε) and pain development in DPN is a crucial question. Read More

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http://dx.doi.org/10.2147/JPR.S186699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338122PMC
January 2019
1 Read

Celiac plexus block increases quality of life in patients with pancreatic cancer.

J Pain Res 2019 14;12:307-315. Epub 2019 Jan 14.

Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary,

Background: Pancreatic cancer is a malignant disease with a high mortality rate and severe pain that is challenging to manage. To reduce the excruciating abdominal pain, opioids and adjuvant agents are conventionally used.

Objectives: PRNCPB is a treatment of neural therapy. Read More

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http://dx.doi.org/10.2147/JPR.S186659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338112PMC
January 2019
1 Read

Effect of preoperative pregabalin on analgesia and interleukins after lumbotomy: prospective, randomized, comparative, double-blind study.

J Pain Res 2019 11;12:339-344. Epub 2019 Jan 11.

Department of Anesthesia, Universidade Federal de São Paulo, São Paulo, Brazil,

Background: Pregabalin is an anticonvulsant and has been used for postoperative analgesia. This study aimed to assess the effect of a single preoperative dose of pregabalin for analgesia after nephrectomy.

Methods: The study was prospective, randomized, comparative, and double-blinded, conducted in 40 kidney transplant donors, between 18 and 60 years, American Society of Anesthesia physical status I or II. Read More

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http://dx.doi.org/10.2147/JPR.S189441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333154PMC
January 2019
2 Reads

Postural counseling represents a novel option in pain management of fibromyalgia patients.

J Pain Res 2019 11;12:327-337. Epub 2019 Jan 11.

Rheumatology Unit, Department of Medicine, University of Verona, Verona, Italy,

Background: Chronic pain is a key symptom in fibromyalgia (FM), and its management is still challenging for rheumatologists in daily practice. FM patients show psychological and psychiatric manifestations, going from mood and emotional disorders to depression and alexithymia that negatively impact their quality of life, limiting their daily activities. Since pharmacological strategies have a limited efficacy in FM pain, alternative or complementary non-pharmacological approaches have been introduced in the clinical management of FM. Read More

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https://www.dovepress.com/postural-counseling-represents-a-n
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http://dx.doi.org/10.2147/JPR.S164714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333156PMC
January 2019
3 Reads

Oral 24% sucrose associated with nonnutritive sucking for pain control in healthy term newborns receiving venipuncture beyond the first week of life.

J Pain Res 2019 8;12:299-305. Epub 2019 Jan 8.

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy,

Objective: To test the hypothesis that oral administration of 24% sucrose associated with nonnutritive sucking in healthy newborns receiving venipuncture beyond the first week of life controls pain and pain-related variation in heart rate (HR) and noninvasive oxygen saturation (SpO).

Methods: A total of 66 term newborns were enrolled between February and September 2017 in the Neonatology Department of AORN Santobono-Pausilipon, Naples. They were randomly assigned to receive oral 1 mL 24% sucrose (treated group [TG], n=33; gestational age 38. Read More

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http://dx.doi.org/10.2147/JPR.S184504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329346PMC
January 2019
1 Read

Quantitative proteomics analysis to identify biomarkers of chronic myofascial pain and therapeutic targets of dry needling in a rat model of myofascial trigger points.

J Pain Res 2019 7;12:283-298. Epub 2019 Jan 7.

Department of Sport Medicine and Rehabilitation Center, Shanghai University of Sport, Shanghai, China,

Background: Proteomics analysis may provide important information regarding the pathogenesis of chronic myofascial pain and the mechanisms underlying the treatment effects of dry needling.

Materials And Methods: This study used a rat model of myofascial trigger points (MTrPs) to perform a proteomics analysis. Three biological replicate experiments were used to compare the proteomes of healthy control rats, a rat model of MTrP, MTrP model rats following dry needling of MTrPs, and MTrP model rats following dry needling of non-MTrPs. Read More

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http://dx.doi.org/10.2147/JPR.S185916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327913PMC
January 2019
1 Read

Characteristics of patients with neuropathic pain syndromes screened by the painDETECT questionnaire and diagnosed by physician exam.

J Pain Res 2019 7;12:255-268. Epub 2019 Jan 7.

UW Center for Pain Relief, University of Washington, Seattle, WA, USA.

Background: The aim of this study was to identify the clinical characteristics, treatment usage, and health outcomes of US adults diagnosed with neuropathic pain (NeP) by experienced physicians.

Methods: Adults with scores exceeding the threshold for probable NeP (painDETECT ≥19) and diagnosed with NeP by a qualified physician completed a questionnaire that included comorbid conditions, pain symptoms and experiences, medication use, health status (3-level EuroQol 5 Dimensions (EQ-5D-3L]: health utilities index and visual analog scale), pain severity and interference with functioning (Brief Pain Inventory), and work and activity impairment (Work Productivity and Activity Impairment questionnaire). Descriptive analyses were performed for each NeP subtype. Read More

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https://www.dovepress.com/characteristics-of-patients-with-n
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http://dx.doi.org/10.2147/JPR.S160513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327912PMC
January 2019
6 Reads

Epidemiology of physician-diagnosed neuropathic pain in Brazil.

J Pain Res 2019 7;12:243-253. Epub 2019 Jan 7.

Pain and Palliative Care Department, Federal University of Maranhão, Maranhão, Brazil.

Objectives: Estimate the prevalence of neuropathic pain (NeP) among chronic pain patients attending Brazilian hospitals and pain clinics in São Paulo, Ceara, and Bahia and explore clinical characteristics by subtypes: painful diabetic peripheral neuropathy (pDPN), central neuropathic pain (CNP), chronic low back pain with a neuropathic component (CLBP-NeP), postherpetic neuralgia (PHN), post-traumatic neuropathic pain (PTN), and post-surgical neuropathic pain (PSN).

Methods: Physicians screened patients reporting chronic pain for ≥3 months (n=2,118) for probable NeP, using the Douleur Neuropathique 4 questionnaire and physician assessment, and reported their NeP subtype(s), symptoms, and medications. Identified NeP patients completed a questionnaire including treatment experiences, quality of life EuroQol 5 Dimensions [EQ-5D]), pain severity and interference (Brief Pain Inventory [BPI]), and Work Productivity and Activity Impairment scales. Read More

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https://www.dovepress.com/epidemiology-of-physician-diagnose
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http://dx.doi.org/10.2147/JPR.S160504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327897PMC
January 2019
5 Reads

Update on the pathophysiology of cluster headache: imaging and neuropeptide studies.

J Pain Res 2019 4;12:269-281. Epub 2019 Jan 4.

Department of Neurology, Hull Royal Infirmary, Hull, UK,

Objective: Cluster headache (CH) is the most severe primary headache condition. Its pathophysiology is multifaceted and incompletely understood. This review brings together the latest neuroimaging and neuropeptide evidence on the pathophysiology of CH. Read More

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http://dx.doi.org/10.2147/JPR.S175312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324919PMC
January 2019
1 Read

Inhibition of electroacupuncture on nociceptive responses of dorsal horn neurons evoked by noxious colorectal distention in an intensity-dependent manner.

J Pain Res 2019 3;12:231-242. Epub 2019 Jan 3.

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China,

Background: The transmission of visceral nociception can be inhibited by electroacupuncture (EA) at the spinal level. However, relationships between current intensity and EA-induced analgesia are still lacking. This study compares the effects of different intensities of EA at local acupoints and heterotopic acupoints on nociceptive responses of spinal wide dynamic range (WDR) neurons induced by noxious colorectal distension (CRD). Read More

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http://dx.doi.org/10.2147/JPR.S182876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322705PMC
January 2019

Analgesic effects of calcitonin on radicular pain in male rats.

J Pain Res 2019 3;12:223-230. Epub 2019 Jan 3.

Department of Orthopaedic Surgery, School of Medicine, Sapporo Medical University, Sapporo 060-0061, Japan,

Purpose: Radicular pain is a frequently observed symptom of lumbar disk herniation or lumbar spinal canal stenosis. Achieving radicular pain relief is difficult. This type of pain may progress to chronic neuropathic pain. Read More

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http://dx.doi.org/10.2147/JPR.S185233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322709PMC
January 2019
1 Read

Intramuscular electrical stimulus potentiates motor cortex modulation effects on pain and descending inhibitory systems in knee osteoarthritis: a randomized, factorial, sham-controlled study.

J Pain Res 2019 3;12:209-221. Epub 2019 Jan 3.

Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil,

Background: Neuroplastic changes in nociceptive pathways contribute to severity of symptoms in knee osteoarthritis (KOA). A new look at neuroplastic changes management includes modulation of the primary motor cortex by transcranial direct current stimulation (tDCS).

Objectives: We investigated whether tDCS combined with intramuscular electrical stimulation (EIMS) would be more efficacious than a sham (s) intervention (s-tDCS/s-EIMS) or a single active(a)-tDCS/s-EIMS intervention and/or s-tDCS/a-EIMS in the following domains: pain measures (visual analog scale [VAS] score and descending pain modulatory system [DPMS], and outcomes, and analgesic use, disability, and pain pressure threshold (PPT) for secondary outcomes. Read More

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http://dx.doi.org/10.2147/JPR.S181019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322702PMC
January 2019
2 Reads

A clinical trial comparing ultrasound-guided ilioinguinal/iliohypogastric nerve block to transversus abdominis plane block for analgesia following open inguinal hernia repair.

J Pain Res 2019 4;12:201-207. Epub 2019 Jan 4.

Pain Research Center, Iran University of Medical Sciences, Tehran, Iran,

Objective: To compare the efficacy of ilioinguinal/iliohypogastric (IINB) nerve block to transversus abdominis plane (TAP) block in controlling incisional pain after open inguinal hernia repair.

Patients And Methods: This was a prospective randomized clinical trial of 90 patients who received either IINB (N=45) or TAP block (N=45) using 0.2% bupivacaine 15 mL under ultrasound (US) guidance based on a random assignment in the postanesthesia care unit after having an open repair of inguinal hernia. Read More

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https://www.dovepress.com/a-clinical-trial-comparing-ultraso
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http://dx.doi.org/10.2147/JPR.S179506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324918PMC
January 2019
6 Reads

Antinociceptive effects of hyaluronic acid on monoiodoacetate-induced ankle osteoarthritis in rats.

J Pain Res 2019 3;12:191-200. Epub 2019 Jan 3.

Department of Orthopaedic surgery, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan,

Purpose: Ankle osteoarthritis (OA) causes significant pain and debilitation; yet, its underlying mechanisms remain unclear. Clinically, hyaluronic acid (HA) is widely used to treat OA. The present study aimed to investigate the roles of HA in pain-related behavior, joint function, swelling, and pathological changes in cartilage in a rat model of monoiodoacetate (MIA)-induced ankle OA. Read More

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http://dx.doi.org/10.2147/JPR.S186413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322704PMC
January 2019

Physical functioning and mindfulness skills training in chronic pain: a systematic review.

J Pain Res 2019 3;12:179-189. Epub 2019 Jan 3.

Department of Psychiatry, Massachusetts General Hospital, Harvard School of Medicine, MA, USA.

Purpose: The importance of improved physical function as a primary outcome in the treatment of chronic pain is widely accepted. There have been limited attempts to assess the effects mindfulness skills training (MST) has on objective outcomes in chronic pain care.

Methods: This systematic review evaluated published reports of original randomized controlled trials that described physical function outcomes after MST in the chronic pain population and met methodological quality according to a list of predefined criteria. Read More

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http://dx.doi.org/10.2147/JPR.S172733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322706PMC
January 2019
1 Read

The effectiveness of ultrasound-guided cervical transforaminal epidural steroid injections in cervical radiculopathy: a prospective pilot study.

J Pain Res 2019 31;12:171-177. Epub 2018 Dec 31.

Department of Anesthesiology, Pain Management Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China,

Background: Cervical transforaminal epidural steroid injection (CTFESI) is used to provide pain relief and restore function in patients with cervical radiculopathy. Traditionally, it is performed under the guidance of fluoroscopy or computed tomography. Here, we introduce a novel technique - ultrasound-guided CTFESI - with which operators can easily distinguish the close soft tissue (nerve, vessels) around the cervical foramina to avoid intravascular injection during the procedure. Read More

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http://dx.doi.org/10.2147/JPR.S181915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318715PMC
December 2018
1 Read

The efficacy of pregabalin for the management of acute and chronic postoperative pain in thoracotomy: a meta-analysis with trial sequential analysis of randomized-controlled trials.

J Pain Res 2019 28;12:159-170. Epub 2018 Dec 28.

Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China,

Purpose: Pregabalin is commonly used as an analgesic for neuropathic pain. But pregabalin as an adjunct to a multimodal analgesic regimen - although standard clinical protocol in some settings - has remained controversial. This meta-analysis was conducted to identify the efficacy of pregabalin for management of postoperative pain in thoracotomy. Read More

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http://dx.doi.org/10.2147/JPR.S183411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312398PMC
December 2018

Preoperational chronic pain impairs the attention ability before surgery and recovery of attention and memory abilities after surgery in non-elderly patients.

J Pain Res 2019 27;12:151-158. Epub 2018 Dec 27.

Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: This study aimed to investigate the relationship of preoperative chronic pain and postoperative cognitive dysfunction (POCD) in non-elderly patients who underwent arthroscopic surgery.

Materials And Methods: The pain intensity was estimated using visual analog scale, and the cognitive function was assessed by Syndrom Kurz Test. The effects of preoperative chronic pain on the cognitive scales were comparatively studied between the patients of observational group (OG, with chronic pain) and control group (CG, without chronic pain) pre- and postoperatively, and followed up for 3 months. Read More

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http://dx.doi.org/10.2147/JPR.S178118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311326PMC
December 2018

Safety of oral methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain.

J Pain Res 2019 24;12:139-150. Epub 2018 Dec 24.

Medical Affairs, Salix Pharmaceuticals, Bridgewater, NJ, USA.

Purpose: Oral methylnaltrexone was shown to be effective in treating opioid-induced constipation (OIC) in patients with chronic noncancer pain in a Phase III randomized controlled trial. This report provides a detailed safety analysis from that study.

Methods: Adults (n=803) with chronic noncancer pain for ≥2 months and confirmed OIC while receiving opioid doses ≥50 mg morphine equivalent per day for ≥14 days were randomized 1:1:1:1 to oral methylnaltrexone (150, 300, or 450 mg) or placebo once daily for 4 weeks, followed by as-needed use for 8 weeks. Read More

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http://dx.doi.org/10.2147/JPR.S170086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307492PMC
December 2018

Naldemedine in Japanese patients with opioid-induced constipation and chronic noncancer pain: open-label Phase III studies.

J Pain Res 2019 24;12:127-138. Epub 2018 Dec 24.

Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Introduction: Naldemedine is a peripherally-acting µ-opioid-receptor antagonist, approved in Japan for opioid-induced constipation (OIC). In two open-label, single-arm, Phase III studies, we evaluated the safety and efficacy of naldemedine in Japanese patients with OIC receiving regular-use opioids (COMPOSE-6) or prolonged-release oxycodone (COMPOSE-7) for chronic noncancer pain.

Methods: Eligible Japanese adults with OIC and chronic noncancer pain received once-daily oral naldemedine 0. Read More

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http://dx.doi.org/10.2147/JPR.S175900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307491PMC
December 2018

Multiple effectiveness aspects of tapentadol for moderate-severe cancer-pain treatment: an observational prospective study.

J Pain Res 2019 24;12:117-125. Epub 2018 Dec 24.

Department of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS - Fondazione G Pascale, Naples, Italy,

Background: Previous studies have shown the efficacy of tapentadol (TP) for chronic cancer pain. We evaluated multiple effectiveness aspects of TP prolonged release on moderate-severe cancer-related pain, neuropathic pain (NeP), patient satisfaction, and quality of life.

Methods: An observational prospective study was conducted on 80 cancer patients. Read More

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http://dx.doi.org/10.2147/JPR.S181079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307493PMC
December 2018
2 Reads

Variables affecting the potential efficacy of PRP in providing chronic pain relief.

Authors:
Damien P Kuffler

J Pain Res 2019 21;12:109-116. Epub 2018 Dec 21.

Institute of Neurobiology, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA,

Although chronic pain affects about 1% of the US population, it remains largely resistant to treatment. Despite great variability in pain outcomes, the application of autologous platelet-rich plasma (PRP) has become increasingly popular in attempts to reduce chronic pain. The variability in PRP efficacy raises the question of whether PRP actually has an analgesic capacity, and if so, can that capacity be made consistent and maximized. Read More

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https://www.dovepress.com/variables-affecting-the-potential-
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http://dx.doi.org/10.2147/JPR.S190065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306069PMC
December 2018
1 Read

Chronic low back pain and postural rehabilitation exercise: a literature review.

J Pain Res 2019 20;12:95-107. Epub 2018 Dec 20.

Department of Physical Medicine and Rehabilitation, Policlinico Universitario Umberto I, Sapienza University, Rome, Italy,

Chronic low back represents one of the major causes of disability worldwide. Our narrative review has the purpose of highlighting the evidence supporting the different rehabilitative techniques described for its management. In total, 26 studies were found suitable to be included in the review (14 articles about pilates, six about McKenzie (MK), one article about Feldenkrais, three about Global Postural Rehabilitation (GPR) and two about Proprioceptive Neuromuscular Facilitation). Read More

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https://www.dovepress.com/chronic-low-back-pain-and-postural
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http://dx.doi.org/10.2147/JPR.S171729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305160PMC
December 2018
9 Reads

Letter to the editor regarding "To what extent are patients with migraine able to predict attacks?"

J Pain Res 2019 20;12:93-94. Epub 2018 Dec 20.

Department of Orthopedics, West China School of Medicine/West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China,

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https://www.dovepress.com/letter-to-the-editor-regarding-to-
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http://dx.doi.org/10.2147/JPR.S191178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305161PMC
December 2018
1 Read

Do etoricoxib and indometacin have similar effects and safety for gouty arthritis? A meta-analysis of randomized controlled trials.

J Pain Res 2019 19;12:83-91. Epub 2018 Dec 19.

Center for Evidence-Based Medicine, Department of Education, Taipei Medical University Hospital, Taipei, Taiwan, Republic of China,

Background: Gout, a common medical condition that causes pain, can be treated by painkillers and anti-inflammatories. Indometacin and etoricoxib are two such drugs. However, no synthesized evidence exists comparing etoricoxib with indometacin in treating patients with gout. Read More

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http://dx.doi.org/10.2147/JPR.S186004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305166PMC
December 2018
7 Reads

Cytokine production capabilities of human primary monocyte-derived macrophages from patients with diabetes mellitus type 2 with and without diabetic peripheral neuropathy.

J Pain Res 2019 19;12:69-81. Epub 2018 Dec 19.

Department of Anesthesiology, Pain Mechanisms Laboratory, Wake Forest University School of Medicine, Winston-Salem, NC, USA,

Introduction: Monocytes from patients with diabetes mellitus type 2 (DM2) are dysfunctional, persistently primed, and prone to a proinflammatory phenotype. This may alter the phenotype of their differentiation to macrophages and result in diabetic peripheral neuropathy (DPN), nerve damage, nerve sensitization, and chronic pain. We have previously demonstrated that CD163 is a molecule that promotes an anti-inflammatory cellular phenotype in human primary macrophages, but this has not been proven in macrophages from patients with DM2 or DPN. Read More

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http://dx.doi.org/10.2147/JPR.S186372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305162PMC
December 2018
2 Reads

The impact of intravenous dexamethasone on the efficacy and duration of analgesia of paravertebral block in breast cancer surgery: a randomized controlled trial.

J Pain Res 2019 19;12:61-67. Epub 2018 Dec 19.

Department of Anesthesia and Pain Management, National Cancer Institute, Cairo University, Giza, Egypt,

Purpose: The study aimed at the evaluation of the impact of intravenous (IV) dexamethasone on efficacy and duration of analgesia of paravertebral block (PVB) in patients undergoing modified radical mastectomy (MRM).

Patients And Methods: This randomized, double-blind controlled trial included 50 patients with breast cancer scheduled for unilateral MRM. Ultrasound-guided PVB was performed in out-of-plane technique. Read More

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http://dx.doi.org/10.2147/JPR.S181788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305158PMC
December 2018
2 Reads

Patient-controlled intravenous tramadol versus patient-controlled intravenous hydromorphone for analgesia after secondary cesarean delivery: a randomized controlled trial to compare analgesic, anti-anxiety and anti-depression effects.

J Pain Res 2019 18;12:49-59. Epub 2018 Dec 18.

Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China,

Introduction: This study aimed to compare the postoperative analgesic effects of tramadol and hydromorphone for secondary cesarean delivery (CD) as well as their anti-anxiety and anti-depression properties.

Methods: A total of 106 patients receiving secondary CD under spinal anesthesia were randomly allocated to the tramadol group (n=53) and the hydromorphone group (n=53). Each group received patient-controlled intravenous analgesia using flurbiprofen 4 mg/kg combined with tramadol (4 mg/kg) or hydromorphone (0. Read More

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http://dx.doi.org/10.2147/JPR.S184782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302801PMC
December 2018
2 Reads

Bidirectional alterations in ALFF across slow-5 and slow-4 frequencies in the brains of postherpetic neuralgia patients.

J Pain Res 2019 18;12:39-47. Epub 2018 Dec 18.

Department of Pain, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, People's Republic of China,

Purpose: Postherpetic neuralgia (PHN) detrimentally affects brain function. Recent studies have suggested that frequency-dependent changes in electroencephalography in chronic pain patients and blood oxygenation level dependent (BOLD) fluctuations can reflect neuronal activity in different frequencies. The current study aimed to investigate PHN-related brain oscillatory activity in a specific frequency band by using the amplitude of low-frequency fluctuation (ALFF) method. Read More

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http://dx.doi.org/10.2147/JPR.S179077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302822PMC
December 2018
1 Read

Postoperative analgesia after combined thoracoscopic-laparoscopic esophagectomy: a randomized comparison of continuous infusion and intermittent bolus thoracic epidural regimens.

J Pain Res 2019 18;12:29-37. Epub 2018 Dec 18.

Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China,

Purpose: Judicious postoperative pain management after thoracoscopic-laparoscopic esophagectomy (TLE) facilitates enhanced rehabilitation. Thoracic epidural analgesia (TEA) offers many benefits in esophagectomy, while several complications are associated with the delivery mode by continuous epidural infusion. This study compared the efficiency and safety of intermittent epidural bolus to continuous epidural infusion for pain management after TLE. Read More

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http://dx.doi.org/10.2147/JPR.S188568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302820PMC
December 2018

Organizing palliative care in the rural areas of Iran: are family physician-based approaches suitable?

J Pain Res 2019 18;12:17-27. Epub 2018 Dec 18.

Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran,

Introduction: The provision of palliative end-of-life care (P/EOLc) for patients, wherever they live, is an increasingly important service, particularly given the increasing rates of cancer and other life-threatening diseases in Iran. However, unfortunately, those living in the rural areas of Iran are greatly disadvantaged with respect to this type of care. Therefore, the present study explored the feasibility of organizing P/EOLc in the rural areas of Iran. Read More

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http://dx.doi.org/10.2147/JPR.S178103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302809PMC
December 2018
1 Read

Evaluation of US Food and Drug Administration-recommended abuse-potential questions in chronic pain patients without history of recreational opioid use: results and plan for research.

J Pain Res 2019 17;12:9-15. Epub 2018 Dec 17.

Medical Affairs, Purdue Pharma, Stamford, CT 06901, USA.

Background: Existing patient-reported outcome (PRO) assessments that measure the human abuse potential for opioid analgesics have been tested exclusively in experienced recreational opioid users, as required by US Food and Drug Administration (FDA) guidance.

Methods: The goals of the current studies were to modify items from FDA-recommended abuse potential PRO assessments to specify the analgesic benefits versus the euphoric effects of opioids and to ascertain the clarity, understandability, appropriateness, and validity of the modified questions. This was achieved by conducting cognitive debriefing interviews (CDIs) with patients (≥18 and <65 years) who have chronic pain, were prescribed an opioid daily dose of at least 80 morphine-equivalent milligrams (>30 days to ≤180 days from the date of interview), and did not have a history of recreational opioid use. Read More

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https://www.dovepress.com/evaluation-of-us-food-and-drug-adm
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http://dx.doi.org/10.2147/JPR.S176950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301309PMC
December 2018
7 Reads

Chronic pain clinic efficiency analysis: optimization through use of the Gantt diagram and visit diagnoses.

J Pain Res 2019 17;12:1-8. Epub 2018 Dec 17.

University of Pittsburgh Physicians, Pittsburgh, PA, USA,

Objective: The aim of this study is to identify scheduling inefficiencies and to develop a personalized schedule based on diagnosis, service time (face-to-face time between the patient and the provider), and patient wait time using a Gantt diagram in a chronic pain clinic.

Design: This is an observational prospective cohort quality improvement (QI) study.

Setting: This study was carried out at a single outpatient multidisciplinary pain management clinic in a university teaching hospital. Read More

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http://dx.doi.org/10.2147/JPR.S173345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301303PMC
December 2018
1 Read

Safety of celecoxib versus traditional nonsteroidal anti-inflammatory drugs in older patients with arthritis.

Authors:
Sooyoung Shin

J Pain Res 2018 14;11:3211-3219. Epub 2018 Dec 14.

Department of clinical Pharmacy, College of Pharmacy, Ajou University, Yeongtong-gu, Suwon, Republic of Korea,

Background: A 2011 systematic review found an increased cardiovascular (CV) risk at both ≤200 mg/day and >200 mg/day doses of celecoxib. This study aimed to evaluate adverse drug events with celecoxib relative to traditional nonsteroidal anti-inflammatory drugs (NSAIDs) in real-world practice settings, focusing on gastrointestinal (GI), CV, and renal toxicity, in older patients with osteoarthritis or rheumatoid arthritis.

Methods: In this population-based retrospective cohort study using national health insurance claims data in Korea, patients aged 65 years and older with arthritis who were treated with celecoxib or traditional NSAIDs for ≥30 days in 2016, were included for study analyses. Read More

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http://dx.doi.org/10.2147/JPR.S186000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299466PMC
December 2018
1 Read

Sublingual sufentanil (Zalviso) patient-controlled analgesia after total knee arthroplasty: a retrospective comparison with oxycodone with or without dexamethasone.

J Pain Res 2018 14;11:3205-3210. Epub 2018 Dec 14.

Department of Anesthesiology, Maasstad Hospital, Rotterdam, The Netherlands.

Postoperative pain is a major problem, especially in orthopedic surgery. Our data suggest suboptimal pain management after total knee arthroplasty. This study evaluated a sufentanil sublingual tablet system (Zalviso) to optimize postoperative pain treatment. Read More

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http://dx.doi.org/10.2147/JPR.S185197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299470PMC
December 2018

Thermovision: a new diagnostic method for orofacial pain?

J Pain Res 2018 13;11:3195-3203. Epub 2018 Dec 13.

Charles University, 3rd Faculty of Medicine, Department of Normal, Pathological and Clinical Physiology, Prague, Czech Republic,

Background: Infrared thermography can be used to obtain more complete information about a patient's condition. The method can be used in various medical applications for monitoring acute and chronic orofacial pain syndrome. With this diagnostic method, thermal differences in the examined region are usually compared to the same reference region on the opposite side of the body. Read More

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http://dx.doi.org/10.2147/JPR.S183096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300380PMC
December 2018
1 Read

The comorbidities of dysmenorrhea: a clinical survey comparing symptom profile in women with and without endometriosis.

J Pain Res 2018 13;11:3181-3194. Epub 2018 Dec 13.

School of Medicine, University of Adelaide, Adelaide, SA, Australia.

Purpose: Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. The frequency of 14 associated symptoms both within and outside the pelvis was determined.

Patients And Methods: Symptom questionnaires were completed by 168 women with dysmenorrhea, allocated to three groups based on their diagnostic status for endometriosis confirmed (Endo+), endometriosis excluded (Endo-), or endometriosis diagnosis unknown (No Lap). Read More

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http://dx.doi.org/10.2147/JPR.S179409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300370PMC
December 2018
2 Reads

A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation.

J Pain Res 2018 13;11:3171-3179. Epub 2018 Dec 13.

Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China,

Background: Neuropathic pain is a common and intractable sequel of brachial plexus injury.

Materials And Methods: To investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury.

Results: Behavioral test of mechanical stimulation suggested that all rats developed neuropathic pain, and the pain thresholds of bilateral hind limbs significantly decreased. Read More

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http://dx.doi.org/10.2147/JPR.S174663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300374PMC
December 2018
1 Read

Epidemiological profiles of chronic low back and knee pain in middle-aged and elderly Japanese from the Murakami cohort.

J Pain Res 2018 12;11:3161-3169. Epub 2018 Dec 12.

Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan,

Purpose: Epidemiological profiles of chronic low back and knee pain have not been studied extensively. This study aimed to determine the prevalence of and potential risk factors associated with chronic low back and knee pain in middle-aged and elderly Japanese.

Methods: This cross-sectional study involved 14,217 community-dwelling individuals aged 40-74 years living in the Murakami area of Japan. Read More

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https://www.dovepress.com/epidemiological-profiles-of-chroni
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http://dx.doi.org/10.2147/JPR.S184746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296201PMC
December 2018
8 Reads

Controlled intervention to compare the efficacies of manual pressure release and the muscle energy technique for treating mechanical neck pain due to upper trapezius trigger points.

J Pain Res 2018 12;11:3151-3160. Epub 2018 Dec 12.

Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia,

Purpose: This study aimed at comparing the clinical efficacies of two manual therapies to determine the most beneficial result-oriented physiotherapeutic approach for treating nonspecific neck pain due to myofascial trigger points (MTrPs).

Methods: This was a randomized, controlled pretest-posttest experimental study that compared manual pressure release (MPR), the muscle energy technique (MET), and a control condition. These techniques were compared using a convenience sample of 45 female participants with neck pain due to MTrPs (mean age±SD=21. Read More

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http://dx.doi.org/10.2147/JPR.S172711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296190PMC
December 2018
1 Read

Vaso-occlusive crisis in sickle cell disease: current paradigm on pain management.

J Pain Res 2018 11;11:3141-3150. Epub 2018 Dec 11.

Department of Pediatrics, College of Medicine, University of Nigeria, Enugu, Nigeria,

This narrative review aims to highlight the current paradigm on pain management in sickle cell vaso-occlusive crisis. It specifically examines the pathophysiologic mechanisms of sickle cell pain as well as the pharmacologic and nonpharmacologic methods of pain management. Recurrent painful episodes constitute the major morbidity in sickle cell disease (SCD). Read More

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http://dx.doi.org/10.2147/JPR.S185582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294061PMC
December 2018
1 Read