1,297 results match your criteria Journal of Pain Research [Journal]


The impact of multisite pain on functional outcomes in older adults: biopsychosocial considerations.

J Pain Res 2019 29;12:1115-1125. Epub 2019 Mar 29.

Department of Aging & Geriatric Research, Institute on Aging, Pain Research & Intervention Center of Excellence, Center for Cognitive Aging & Memory, University of Florida, Gainesville, FL 32610, USA,

Multisite pain, or pain that occurs simultaneously at >1 anatomical site, is more prevalent than single-site pain. While multisite pain affects over half of older adults, it remains an understudied pain entity that may have important functional implications in an aging population. Greater understanding of this complex pain entity from a biopsychosocial perspective is critical for optimizing clinical and functional outcomes in older adults with pain. Read More

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http://dx.doi.org/10.2147/JPR.S192755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445225PMC

Nonsurgical integrative inpatient treatments for symptomatic lumbar spinal stenosis: a multi-arm randomized controlled pilot trial.

J Pain Res 2019 28;12:1103-1113. Epub 2019 Mar 28.

Department of Anesthesiology, Division of Pain Medicine, Mayo Clinic, Rochester, MN, USA,

Background: Lumbar spinal stenosis (LSS) is a chronic condition that causes low back pain and neurogenic claudication, often resulting in significant limitation of daily activities. In this open-label randomized controlled pilot study, we assessed the safety and feasibility of 4-week novel integrative inpatient treatments for LSS.

Methods: Thirty-six symptomatic LSS patients were randomly and equally allocated to one of the three groups: Mokhuri Chuna treatment 1 (MT1) group, Mokhuri Chuna treatment 2 (MT2) group, or conventional management treatment (CMT) group. Read More

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https://www.dovepress.com/nonsurgical-integrative-inpatient-
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http://dx.doi.org/10.2147/JPR.S173178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445233PMC
March 2019
1 Read

Radio contrast imaging for continuous epidural infusion in humans: a report of three cases.

J Pain Res 2019 25;12:1077-1082. Epub 2019 Mar 25.

Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan,

There are no reports of human research on continuous epidural contrast injection, and there are no definite methods to investigate the spread of drugs injected continuously into the epidural space. We investigated the feasibility of continuous epidural contrast injection in patients undergoing computed tomography (CT)-guided therapy. In this study, a combination of a contrast agent mixed with 0. Read More

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https://www.dovepress.com/radio-contrast-imaging-for-continu
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http://dx.doi.org/10.2147/JPR.S193500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438137PMC
March 2019
2 Reads

: from recreational hallucinogenic use to analgesic and anti-inflammatory action.

J Pain Res 2019 22;12:1069-1076. Epub 2019 Mar 22.

Research in Neurosciences, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, México,

is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Read More

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https://www.dovepress.com/salvia-divinorum-from-recreational
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http://dx.doi.org/10.2147/JPR.S188619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434906PMC
March 2019
1 Read

The efficacy of pregabalin for the treatment of neuropathic pain in Japanese subjects with moderate or severe baseline pain.

J Pain Res 2019 22;12:1061-1068. Epub 2019 Mar 22.

Global Statistics, Pfizer Inc, New York, NY, USA.

Purpose: Although analyses of pooled clinical trial data have reported how international populations respond to pregabalin by baseline neuropathic pain (NeP) severity, no studies have evaluated this specifically in patients from Japan. Thus, this post hoc pooled analysis evaluated the efficacy of pregabalin in Japanese subjects for treating moderate or severe baseline NeP.

Patients And Methods: Data were pooled from three placebo-controlled trials enrolling Japanese subjects with postherpetic neuralgia (PHN), diabetic peripheral neuropathy (DPN), and spinal cord injury (SCI). Read More

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http://dx.doi.org/10.2147/JPR.S181729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434920PMC
March 2019
1 Read

Aggregation properties of triamcinolone acetonide injection in human serum: considerations when performing epidural steroid injections.

J Pain Res 2019 20;12:1033-1039. Epub 2019 Mar 20.

Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.

Background: Morbidity has been reported as a sequelae of crystalline steroid epidural steroid injections (ESIs), and particulate steroid size, aggregation, and embolization in brain and spinal cord may be the mechanism related to these neurologic effects.

Objective: The objective of the study was to examine the aggregation properties of triamcinolone acetonide in commonly used local anesthetics with and without human serum.

Setting: This study was conducted in an academic tertiary care center. Read More

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http://dx.doi.org/10.2147/JPR.S181038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430988PMC
March 2019
3 Reads

Validation of the Swedish version of the Pain Catastrophizing Scale for Parents (PCS-P) for parents of children with cancer.

J Pain Res 2019 18;12:1017-1023. Epub 2019 Mar 18.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden,

Objectives: Pain is reported as one of the most common and burdensome symptoms for children with cancer. Pain catastrophizing is clearly related to pain intensity and disability. Catastrophizing in parents is associated with both child functioning and parent distress. Read More

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http://dx.doi.org/10.2147/JPR.S193164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430182PMC

Activation of hippocampal microglia in a murine model of cancer-induced pain.

J Pain Res 2019 18;12:1003-1016. Epub 2019 Mar 18.

Michael G. DeGroote Institute for Pain Research and Care, Medicine, McMaster University, Hamilton, ON L8S 4M1, Canada,

Introduction: Pain is a common and debilitating comorbidity of metastatic breast cancer. The hippocampus has been implicated in nociceptive processing, particularly relating to the subjective aspect of pain. Here, a syngeneic mouse model was used to characterize the effects of peripheral tumors on hippocampal microglial activation in relation to cancer-induced pain (CIP). Read More

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http://dx.doi.org/10.2147/JPR.S191860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430067PMC
March 2019
1 Read

Pooled analysis of tanezumab efficacy and safety with subgroup analyses of phase III clinical trials in patients with osteoarthritis pain of the knee or hip.

J Pain Res 2019 19;12:975-995. Epub 2019 Mar 19.

Pfizer Inc, Groton, CT, USA.

Purpose: A pooled analysis was conducted to evaluate tanezumab efficacy and safety in patients with osteoarthritis (OA), including subgroup analyses of at-risk patients with diabetes, severe OA symptoms, and those aged ≥65 years.

Patients And Methods: Data from phase III placebo-controlled clinical trials of patients with moderate-to-severe OA of the knee or hip were pooled to evaluate tanezumab efficacy (four trials) and safety (nine trials). Patients received intravenous tanezumab, tanezumab plus an oral NSAID (naproxen, celecoxib, or diclofenac), active comparator (naproxen, celecoxib, diclofenac, or oxycodone), or placebo. Read More

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http://dx.doi.org/10.2147/JPR.S191297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430070PMC
March 2019
3 Reads

Translation, validation, and cross-cultural adaptation of the Polish version of the pain sensitivity questionnaire.

J Pain Res 2019 14;12:969-973. Epub 2019 Mar 14.

Department of Neurosurgery, University Hospital, Zielona Gora, Poland.

Introduction: The purpose of this study was to provide a translation, cross-cultural adaptation, and validation of the Polish language version of the pain sensitivity questionnaire (PSQ). The process followed widely accepted guidelines.

Methods: The translated questionnaire underwent thorough psychometric testing. Read More

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http://dx.doi.org/10.2147/JPR.S189427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421867PMC

Pain here and now: physical pain impairs transcendence of psychological distance.

J Pain Res 2019 11;12:961-968. Epub 2019 Mar 11.

Department of Psychology, Linnaeus University, 391 82 Kalmar, Sweden,

Background: The ability to traverse psychological distance by going beyond the experienced reality of the self, here and now, is fundamental for effective human functioning. Yet, little is known about how physical pain affects transcendence of psychological distance. Using a construal level theory framework of psychological distance, the current research examines the hypothesis that pain impairs people's ability to traverse any kind of psychological distance whether it be temporal, social, and spatial distance, or the hypothetical. Read More

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http://dx.doi.org/10.2147/JPR.S194114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417848PMC

Ultrasound-guided serratus anterior plane block for analgesia after thoracic surgery.

J Pain Res 2019 11;12:953-960. Epub 2019 Mar 11.

Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel,

Background: Patients who undergo surgical procedures that impair the integrity of the chest wall frequently experience extremely severe postoperative pain. Opiates and weaker analgesics, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are not sufficiently effective in achieving control of severe pain and might cause respiratory and gastrointestinal complications. In the past decade, there has been an increased interest in the use of regional nerve blocks for post-thoracoscopy and post-thoracotomy analgesia. Read More

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http://dx.doi.org/10.2147/JPR.S191263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417847PMC

Erratum: Postural counseling represents a novel option in pain management of fibromyalgia patients [Erratum].

Authors:

J Pain Res 2019 11;12:951. Epub 2019 Mar 11.

[This corrects the article on p. 327 in vol. 12, PMID: 30666151. Read More

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http://dx.doi.org/10.2147/JPR.S205022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417849PMC
March 2019
1 Read

Near-resolution of persistent idiopathic facial pain with low-dose lumbar intrathecal ziconotide: a case report.

J Pain Res 2019 8;12:945-949. Epub 2019 Mar 8.

University of Pittsburgh Physicians, Pittsburgh, PA, USA,

Purpose: Persistent idiopathic facial pain (PIFP) is a poorly defined and debilitating chronic pain state with a challenging and often inadequate treatment course. This is the first case report identifying the novel use of low-dose lumbar intrathecal ziconotide to successfully treat PIFP with nearly complete resolution of pain and minimal to no side effects.

Methods: The patient was a 37 year-old female whose PIFP was refractory to multimodal medication management and multiple neurovascular surgical interventions. Read More

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http://dx.doi.org/10.2147/JPR.S193746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413753PMC

APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy.

J Pain Res 2019 11;12:927-943. Epub 2019 Mar 11.

Lotus Clinical Research, LLC, Pasadena, CA, USA.

Purpose: Oliceridine is a novel G protein-biased µ-opioid receptor agonist designed to provide intravenous (IV) analgesia with a lower risk of opioid-related adverse events (ORAEs) than conventional opioids.

Patients And Methods: APOLLO-1 (NCT02815709) was a phase III, double-blind, randomized trial in patients with moderate-to-severe pain following bunionectomy. Patients received a loading dose of either placebo, oliceridine (1. Read More

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http://dx.doi.org/10.2147/JPR.S171013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417853PMC

Effect of specific deep cervical muscle exercises on functional disability, pain intensity, craniovertebral angle, and neck-muscle strength in chronic mechanical neck pain: a randomized controlled trial.

J Pain Res 2019 7;12:915-925. Epub 2019 Mar 7.

School of Health Sciences (Physiotherapy), University of South Australia, Adelaide, SA, Australia.

Background: Exercise is known to be an important component of treatment programs for individuals with neck pain. The study aimed to compare the effects of semispinalis cervicis (extensor) training, deep cervical flexor (flexor) training, and usual care (control) on functional disability, pain intensity, craniovertebral (CV) angle, and neck-muscle strength in chronic mechanical neck pain.

Methods: A total of 54 individuals with chronic mechanical neck pain were randomly allocated to three groups: extensor training, flexor training, or control. Read More

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http://dx.doi.org/10.2147/JPR.S190125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411318PMC

Increased cerebral nuclear factor kappa B in a complex regional pain syndrome rat model: possible relationship between peripheral injury and the brain.

J Pain Res 2019 6;12:909-914. Epub 2019 Mar 6.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea,

Purpose: Complex regional pain syndrome (CRPS) is a rare but refractory pain disorder. Recent advanced information retrieval studies using text-mining and network analysis have suggested nuclear factor kappa B (NFκB) as a possible central mediator of CRPS. The brain is also known to play important roles in CRPS. Read More

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http://dx.doi.org/10.2147/JPR.S166270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408925PMC
March 2019
1 Read

Who benefits from multimodal rehabilitation - an exploration of pain, psychological distress, and life impacts in over 35,000 chronic pain patients identified in the Swedish Quality Registry for Pain Rehabilitation.

J Pain Res 2019 7;12:891-908. Epub 2019 Mar 7.

School of Law, Psychology and Social Work, Örebro University, Örebro, Sweden.

Background: Chronic pain patients frequently suffer from psychological symptoms. There is no consensus concerning the prevalence of severe anxiety and depressive symptoms and the strength of the associations between pain intensity and psychological distress. Although an important aspect of the clinical picture is understanding how the pain condition impacts life, little is known about the relative importance of pain and psychological symptoms for individual's life impact. Read More

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http://dx.doi.org/10.2147/JPR.S190003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411315PMC

Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1α pathway.

J Pain Res 2019 4;12:879-890. Epub 2019 Mar 4.

Department of Anesthesiology, The Third Hospital of Hebei Medical University, Qiaoxi District, Shijiazhuang 050051, China,

Background: Phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) is one of the essential signaling pathways for the development and maintenance of neuropathic pain.

Objective: To investigate the effect of resveratrol (RES) on paclitaxel-induced neuropathic pain in rats and elucidate the underlying molecular mechanisms.

Method: Male Sprague Dawley rats were randomly divided into seven groups (n=10/group): Group C, Group P, Group R, Group R+P, Group LY + R+P, Group LY (the specific inhibitor of PI3K), Group E (the specific inhibitor of sirtuin 1 [SIRT1]). Read More

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https://www.dovepress.com/resveratrol-inhibits-paclitaxel-in
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http://dx.doi.org/10.2147/JPR.S185873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404678PMC
March 2019
8 Reads

Qualitative evaluation of an interdisciplinary chronic pain intervention: outcomes and barriers and facilitators to ongoing pain management.

J Pain Res 2019 1;12:865-878. Epub 2019 Mar 1.

South Texas Veterans Health Care System, San Antonio, TX 78229, USA,

Background: Many leaders in the field of chronic pain treatment consider interdisciplinary pain management programs to be the most effective treatments available for chronic pain. As programs are instituted and expanded to address demands for nonpharmacological chronic pain interventions, we need to better understand how patients experience program impacts, as well as the challenges and supports patients encounter in trying to maintain and build on intervention gains.

Methods: We conducted a qualitative evaluation of an interdisciplinary chronic pain coaching program at the Atlanta Veterans Affairs. Read More

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http://dx.doi.org/10.2147/JPR.S185652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402709PMC

Gaining insights on the influence of attention, anxiety, and anticipation on pain perception.

J Pain Res 2019 1;12:851-864. Epub 2019 Mar 1.

Psychology Department, James Cook University, Singapore,

Purpose: This article highlights the influence of attention and pain anticipation on pain attenuation. Pain-related trait anxiety was found to moderate the effect that attention strategies impose on pain perception. This article may contribute to clinical treatments quality, where pain attenuation effect is desired. Read More

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http://dx.doi.org/10.2147/JPR.S176889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402711PMC

The low-frequency BOLD signal oscillation response in the insular associated to immediate analgesia of ankle acupuncture in patients with chronic low back pain.

J Pain Res 2019 28;12:841-850. Epub 2019 Feb 28.

School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, China,

Purpose: The present study evaluated the modulation effect of a painless acupuncture technique, ankle acupuncture (AA), on resting-state functional change in patients with chronic low back pain (CLBP).

Patients And Methods: Fourteen participants diagnosed with CLBP received AA and underwent one brain functional image scan after tactile stimulation and another one following the insertion of the needle. The needling sensations and clinical pain intensities were evaluated after the end of each functional image scan. Read More

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http://dx.doi.org/10.2147/JPR.S189390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400126PMC
February 2019
1 Read

Pharmacotherapeutic outcomes in atypical odontalgia: determinants of pain relief.

J Pain Res 2019 27;12:831-839. Epub 2019 Feb 27.

Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan,

Objectives: There has been considerable research which has focused on clarifying the origin of pain in patients with atypical odontalgia (AO), also known as "idiopathic toothache", and on identifying effective treatment, but there has been limited success so far. In this study, we assessed the outcomes of treatment and attempted to identify factors that could account for pain remission in patients with AO.

Patients And Methods: Data for 165 patients diagnosed with AO from June 2015 to August 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.2147/JPR.S188362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398971PMC
February 2019

Neuromodulation with electrical field stimulation of dorsal root ganglion in various pain syndromes: a systematic review with focus on participant selection.

J Pain Res 2019 27;12:803-830. Epub 2019 Feb 27.

Center for Evidence-Based Medicine and Health Care, Catholic University of Croatia, 10000 Zagreb, Croatia,

Objective: We conducted a systematic review about patient selection, efficacy, and safety of neuromodulation with electrical field stimulation (EFS) of dorsal root ganglion (DRG) in various painful conditions. We also analyzed conclusion statements as well as conflict of interest and financing of the included studies.

Methods: All study designs were eligible for inclusion. Read More

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http://dx.doi.org/10.2147/JPR.S168814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398970PMC
February 2019

Neuroleptanalgesia for acute abdominal pain: a systematic review.

J Pain Res 2019 26;12:787-801. Epub 2019 Feb 26.

Department of Emergency Medicine, State University of New York Downstate Medical Center, Brooklyn, NY, USA.

Background: Acute abdominal pain (AAP) comprises up to 10% of all emergency department (ED) visits. Current pain management practice is moving toward multi-modal analgesia regimens that decrease opioid use.

Objective: This project sought to determine whether, in patients with AAP (population), does administration of butyrophenone antipsychotics (intervention) compared to placebo, usual care, or opiates alone (comparisons) improve analgesia or decrease opiate consumption (outcomes)?

Methods: A structured search was performed in Cochrane CENTRAL, CINAHL, Database of Abstracts of Reviews of Effects, Directory of Open Access Journals, Embase, IEEE-Xplorer, Latin American and Caribbean Health Sciences Literature, Magiran, PubMed, Scientific Information Database, Scopus, TÜBİTAK ULAKBİM, and Web of Science. Read More

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http://dx.doi.org/10.2147/JPR.S187798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396833PMC
February 2019
3 Reads

Association between COMT polymorphism, labor anxiety, and analgesia in pregnant women.

J Pain Res 2019 27;12:779-785. Epub 2019 Feb 27.

Department of Anesthesiology and Pain Management, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China,

Background: COMT gene polymorphism is associated with mental disorders and sensitivity to pain. In this study, we investigated the association between the COMT gene polymorphism and labor anxiety and analgesia in pregnant women.

Subjects And Methods: A total of 425 pregnant women undergoing labor analgesia were selected from May 2016 to February 2018. Read More

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http://dx.doi.org/10.2147/JPR.S192719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398968PMC
February 2019

Pain incidence, assessment, and management in Vietnam: a cross-sectional study of 12,136 respondents.

J Pain Res 2019 25;12:769-777. Epub 2019 Feb 25.

Department of Anesthesia and Pain Medicine, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam,

Objective: To describe the rate and demographics of pain among Vietnamese people in 48 provinces and describe the impact of pain on individuals, levels of satisfaction with treatment results, and behavior of pain sufferers.

Methods: The cross-sectional study was conducted in adults presenting to outpatient clinics throughout 48 provinces in Vietnam and were randomly selected for inclusion in this study. A physician trained to administer a questionnaire in a standardized fashion interviewed each patient and collected data regarding gender, age, career, acute and chronic pain, diagnoses, treatment, and satisfaction with treatment. Read More

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http://dx.doi.org/10.2147/JPR.S184713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394241PMC
February 2019

Platelet-rich plasma in the management of chronic low back pain: a critical review.

J Pain Res 2019 25;12:753-767. Epub 2019 Feb 25.

Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, CA 92093-0863, USA.

Low back pain (LBP) is now regarded as the first cause of disability worldwide and should be a priority for future research on prevention and therapy. Intervertebral disc (IVD) degeneration is an important pathogenesis of LBP. Platelet-rich plasma (PRP) is an autologous blood concentrate that contains a natural concentration of autologous growth factors and cytokines and is currently widely used in the clinical setting for tissue regeneration and repair. Read More

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http://dx.doi.org/10.2147/JPR.S153085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394242PMC
February 2019

Impact of transcutaneous electrical nerve stimulation on sleep in chronic low back pain: a real-world retrospective cohort study.

J Pain Res 2019 25;12:743-752. Epub 2019 Feb 25.

NeuroMetrix, Inc., Waltham, MA 02451, USA,

Objective: The purpose of this study was to determine if transcutaneous electrical nerve stimulation (TENS) improves sleep in chronic low back pain (CLBP).

Background: There is uncertainty over the effectiveness of TENS in CLBP. In most studies, pain intensity has been the primary outcome measure. Read More

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http://dx.doi.org/10.2147/JPR.S196129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394244PMC
February 2019
1 Read

Educational intervention for promoting stretching exercise behavior among a sample of Iranian office employees: applying the Health Promotion Model.

J Pain Res 2019 22;12:733-742. Epub 2019 Feb 22.

Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Introduction: Health Promotion Model (HPM) is one comprehensive model by which health behavior predicting factors could be determined.

Purpose: This study aimed to investigate the effects of a designed interventional program based on HPM on promoting stretching exercise (SE) behavior among office employees.

Patients And Methods: This interventional designed study was carried out on 87 office employees who were working in the three health networks affiliated to Shahid Beheshti University of Medical Sciences in Tehran, Iran. Read More

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https://www.dovepress.com/educational-intervention-for-promo
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http://dx.doi.org/10.2147/JPR.S183410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391131PMC
February 2019
4 Reads

Understanding factors that contribute to the disposal of unused opioid medication.

J Pain Res 2019 19;12:725-732. Epub 2019 Feb 19.

Purdue Pharma LP, Medical Affairs, Stamford, CT 06901, USA,

Purpose: Drivers of excess controlled substance disposal behaviors are not well understood. A survey of patients who had received opioid-based medications was conducted to inform the design of future innovative drug take-back programs.

Methods: This was a cross-sectional survey study conducted in 152 participants who received treatment with an opioid within the previous 2 years and had possession of unused medication following either switching to a different opioid or discontinuation of pain. Read More

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http://dx.doi.org/10.2147/JPR.S171742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388750PMC
February 2019

Chronic localized back pain due to entrapment of cutaneous branches of posterior rami of the thoracic nerves (POCNES): a case series on diagnosis and management.

J Pain Res 2019 19;12:715-723. Epub 2019 Feb 19.

SolviMáx, Center of Expertise for ACNES, Center of Excellence for Chronic Abdominal Wall and Groin Pain, Department of Surgery, Máxima Medical Center, Veldhoven, The Netherlands,

Introduction And Aim: Chronic back pain (CBP) may be caused by a variety of conditions including dysfunctional muscles, ligaments or intervertebral discs, improper movement of vertebral column joints, or nerve root compression. Recently, CBP was treated successfully in a patient having an entrapment of cutaneous branches of the posterior rami of the thoracic nerves, termed posterior cutaneous nerve entrapment syndrome (POCNES). Our aim is to describe clinical presentation, differential diagnosis, and management of patients with such a neuropathic pain syndrome. Read More

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http://dx.doi.org/10.2147/JPR.S178492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388752PMC
February 2019
1 Read

Multimodal approaches and tailored therapies for pain management: the trolley analgesic model.

J Pain Res 2019 19;12:711-714. Epub 2019 Feb 19.

Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS - Fondazione G Pascale, Naples, Italy,

Chronic pain is described as a manifestation of real or potential tissue damage. It is identified as a perception influenced by the complex interactions of biological, psychological, and social factors. Different types of pain and their comorbidities dramatically affect patients' quality of life and their families. Read More

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http://dx.doi.org/10.2147/JPR.S178910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388734PMC
February 2019
3 Reads

Could epigenetics help explain racial disparities in chronic pain?

J Pain Res 2019 18;12:701-710. Epub 2019 Feb 18.

Department of Psychology, College of Arts and Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.

African Americans disproportionately suffer more severe and debilitating morbidity from chronic pain than do non-Hispanic Whites. These differences may arise from differential exposure to psychosocial and environmental factors such as adverse childhood experiences, racial discrimination, low socioeconomic status, and depression, all of which have been associated with chronic stress and chronic pain. Race, as a social construct, makes it such that African Americans are more likely to experience different early life conditions, which may induce epigenetic changes that sustain racial differences in chronic pain. Read More

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https://www.dovepress.com/could-epigenetics-help-explain-rac
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http://dx.doi.org/10.2147/JPR.S191848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388771PMC
February 2019
8 Reads

Low-dose methoxyflurane analgesia in adolescent patients with moderate-to-severe trauma pain: a subgroup analysis of the STOP! study.

J Pain Res 2019 15;12:689-700. Epub 2019 Feb 15.

Data Management & Statistics, Mundipharma Research Limited, Cambridge, UK.

Introduction: The undertreatment of acute pain presents a significant challenge in the Emergency Department. This post hoc subgroup analysis of a previously reported randomized controlled UK study reports the efficacy and safety of low-dose methoxyflurane analgesia in treating adolescent patients with moderate-to-severe trauma pain.

Patients And Methods: Three hundred patients (96 in the adolescent subgroup) aged ≥12 years requiring analgesia for acute trauma pain (pain score of 4-7 on the Numerical Rating Scale) at triage were randomized 1:1 to methoxyflurane (up to 6 mL) or placebo (normal saline), both administered using a Penthrox inhaler. Read More

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http://dx.doi.org/10.2147/JPR.S188675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388743PMC
February 2019

Evaluation of association factors for labor episodic pain during epidural analgesia.

J Pain Res 2019 15;12:679-687. Epub 2019 Feb 15.

Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore,

Purpose: Epidural analgesia provides safe and effective labor pain relief. However, labor episodic pain can occur during epidural analgesia, requiring epidural top-ups, and may result in decreased patient satisfaction. The primary aim of our study was to investigate the factors associated with labor episodic pain during epidural analgesia. Read More

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https://www.dovepress.com/evaluation-of-association-factors-
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http://dx.doi.org/10.2147/JPR.S185073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388742PMC
February 2019
6 Reads

TRPV1 channel contributes to remifentanil-induced postoperative hyperalgesia via regulation of NMDA receptor trafficking in dorsal root ganglion.

J Pain Res 2019 15;12:667-677. Epub 2019 Feb 15.

Tianjin Research Institute of Anesthesiology, Tianjin, China,

Background: Remifentanil is widely used in general anesthesia due to its reliability and rapid onset. However, remifentanil-induced postoperative hyperalgesia might be a challenge nowadays. Accumulating evidence suggests that the transient receptor potential vanilloid 1 (TRPV1) was involved in the development of neuropathic pain and hyperalgesia. Read More

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http://dx.doi.org/10.2147/JPR.S186591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388729PMC
February 2019
1 Read

Intraoperative administration of intravenous flurbiprofen axetil with nalbuphine reduces postoperative pain after orbital decompression: a single-center, prospective randomized controlled trial.

J Pain Res 2019 14;12:659-665. Epub 2019 Feb 14.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China,

Purpose: This study aimed to investigate postoperative analgesia achieved with intraoperative administration of intravenous flurbiprofen axetil and nalbuphine in patients undergoing orbital decompression.

Methods: Sixty-three patients undergoing orbital decompression under general anesthesia at the Zhongshan Ophthalmic Center at Sun Yat-sen University (Guangzhou, China) were randomly allocated into one of the following three groups (1:1:1): intraoperative flurbiprofen axetil 100 mg (Group 1); intraoperative nalbuphine 0.1 mg/kg (Group 2); or intraoperative flurbiprofen axetil 100 mg combined with nalbuphine 0. Read More

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http://dx.doi.org/10.2147/JPR.S187020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388751PMC
February 2019

Opioid moderatism and the imperative of rapprochement in pain medicine.

J Pain Res 2019 12;12:649-657. Epub 2019 Feb 12.

Department of Diagnostic Sciences, Tufts University School of Dental Medicine, Boston, MA, USA.

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http://dx.doi.org/10.2147/JPR.S198849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388760PMC
February 2019

Partial sciatic nerve ligation leads to an upregulation of Ni-resistant T-type Ca currents in capsaicin-responsive nociceptive dorsal root ganglion neurons.

J Pain Res 2019 11;12:635-647. Epub 2019 Feb 11.

Department of Epileptology, University of Bonn Medical Center, Bonn, Germany,

Background: Neuropathic pain resulting from peripheral nerve lesions is a common medical condition, but current analgesics are often insufficient. The identification of key molecules involved in pathological pain processing is a prerequisite for the development of new analgesic drugs. Hyperexcitability of nociceptive DRG-neurons due to regulation of voltage-gated ion-channels is generally assumed to contribute strongly to neuropathic pain. Read More

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http://dx.doi.org/10.2147/JPR.S138708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375107PMC
February 2019
1 Read

An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic /Combogesic) in adults.

J Pain Res 2019 8;12:621-634. Epub 2019 Feb 8.

Drug Development, AFT Pharmaceuticals Ltd, Auckland, New Zealand,

Introduction: Acetaminophen (APAP) and ibuprofen (IBP) are two analgesic compounds with a long history of use. Both are considered safe at recommended over-the-counter daily doses. Chronic use, high doses, or concomitant medication can produce safety risks for both drugs. Read More

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http://dx.doi.org/10.2147/JPR.S189605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371943PMC
February 2019

Altered gray matter volume in patients with herpes zoster and postherpetic neuralgia.

J Pain Res 2019 7;12:605-616. Epub 2019 Feb 7.

Department of Radiology,

Purpose: The aim of this study was to measure brain alterations in patients with herpes zoster (HZ) and postherpetic neuralgia (PHN) and compare their differences using a voxel-based morphometry (VBM) technique.

Materials And Methods: Thirty-three patients with HZ, 22 patients with PHN, and 28 well-matched healthy controls (HCs) were recruited. Magnetic resonance imaging data were acquired for all subjects and analyzed using the VBM method. Read More

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http://dx.doi.org/10.2147/JPR.S183561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369852PMC
February 2019
1 Read

Non-inferiority trial of a pedal controlled injection device: a step toward enhancing patient safety and operator independence during neural blockade.

J Pain Res 2019 7;12:571-577. Epub 2019 Feb 7.

Department of Anesthesiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA,

Background And Objectives: Limitations in manpower in health care facilities, both in civilian and military settings, can severely affect patient safety as well as overall outcomes. Regional anesthesia via neural blockade is an effective means of managing uncontrolled acute pain, which has been associated with cardiopulmonary, endocrine, immunologic, and hematologic derangement in addition to the development of potentially life-threatening coagulopathy. We have designed a remote-controlled injection device that may expedite the performance of regional nerve blocks in these situations. Read More

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http://dx.doi.org/10.2147/JPR.S166335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369836PMC
February 2019

Preoperative ultrasound-guided multilevel paravertebral blocks reduce the incidence of postmastectomy chronic pain: a double-blind, placebo-controlled randomized trial.

J Pain Res 2019 5;12:597-603. Epub 2019 Feb 5.

Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China,

Purpose: Chronic postsurgical pain is a challenging problem after breast cancer surgery. This prospective, randomized, double-blinded, parallel-group, placebo-controlled trial was conducted to evaluate the influence of preoperative ultrasound-guided multilevel paravertebral blocks (PVBs) on chronic pain following mastectomy.

Patients And Methods: One hundred eighty-four women were randomized to receive ultrasound-guided multilevel (T1-T5) PVBs with 5 mL of ropivacaine 0. Read More

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http://dx.doi.org/10.2147/JPR.S190201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368114PMC
February 2019

Does experimentally induced pain affect attention? A meta-analytical review.

J Pain Res 2019 4;12:585-595. Epub 2019 Feb 4.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China,

Background: Recent studies have found that clinical pain is related to cognitive impairment. However, there remains a scarcity of systematic reviews on the influence of acute pain on attention. Laboratory-induced pain is often used to simulate acute pain. Read More

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http://dx.doi.org/10.2147/JPR.S184183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368116PMC
February 2019
1 Read

The comparison of the effectiveness between different doses of local methylprednisolone injection versus triamcinolone in Carpal Tunnel Syndrome: a double-blind clinical trial.

J Pain Res 2019 5;12:579-584. Epub 2019 Feb 5.

Department of Medical Genetics, Tarbiat Modares University, Tehran, Iran.

Purpose: Local corticosteroid injection is one of the most prevalent methods in treating carpal tunnel syndrome (CTS). However, the most efficient substance and its appropriate dosage remain controversial. In the present double-blind randomized controlled trial, the efficacy and safety of local injection of two corticosteroids (triamcinolone and methylprednisolone) were compared at two different dosages, 20 and 40 mg. Read More

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http://dx.doi.org/10.2147/JPR.S190652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368124PMC
February 2019
1 Read

Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity.

J Pain Res 2019 31;12:545-556. Epub 2019 Jan 31.

Centro de Ciências da Saúde - Departamento de Nutrição da Universidade Federal De Santa Catarina, Florianopolis, Brazil.

Objective: This study compared urinary 6-sulfatoxymelatonin (aMT6s) over 24 hours among fibromyalgia (FM), major depression disorder (MDD), and healthy control (HC) groups, and examined whether rhythm is correlated with depressive symptoms. To answer this question we compared the rhythm of urinary aMT6s secretion among each group in four time series: morning (06:00-12:00 hours), afternoon (12:00-18:00 hours), evening (18:00-24:00 hours), and night (24:00-06:00 hours). In the FM subjects, we assessed if the rhythm of urinary aMT6s secretion is associated with pain severity, sleep quality, number of trigger points (NTPs), and the pain pressure threshold (PPT). Read More

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http://dx.doi.org/10.2147/JPR.S176857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365222PMC
January 2019
8 Reads

Acupuncture therapy for fibromyalgia: a systematic review and meta-analysis of randomized controlled trials.

J Pain Res 2019 30;12:527-542. Epub 2019 Jan 30.

The Second Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China Email

Purpose: Fibromyalgia (FM) can cause chronic widespread pain and seriously affect the quality of patient lives. Acupuncture therapy is widely used for pain management. However, the effect of acupuncture on FM is still uncertain. Read More

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http://dx.doi.org/10.2147/JPR.S186227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365227PMC
January 2019
2 Reads