2,385 results match your criteria Journal of Pain & Palliative Care Pharmacotherapy[Journal]


Systematic review and neural network analysis to define predictive variables in implantable motor cortex stimulation to treat chronic intractable pain.

J Pain 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands; Unit of Functional Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands.

Implantable Motor Cortex Stimulation (iMCS) has been performed for over 25 years to treat various intractable pain syndromes. Its effectiveness shows to be highly variable and although various studies revealed predictive variables, none of these were found repeatedly. This study uses neural network analysis (NNA) to identify predictive factors of iMCS treatment of intractable pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.004DOI Listing
February 2019

Somatic symptoms in pediatric patients with chronic pain: Proposed clinical reference points for the Children's Somatic Symptoms Inventory (formerly Children's Somatization Inventory).

J Pain 2019 Feb 13. Epub 2019 Feb 13.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA.

Among youth with chroic pain, elevated somatic symptoms across multiple body systems have been associated with greater emotional distress and functional disability and could represent poor adaptation to pain. The Children's Somatic Symptoms Inventory (formerly the Children's Somatization Inventory) is commonly used to assess somatic symptoms in children. However, no studies have evaluated the clinical utility of the measure in the assessment of pediatric patients with chronic pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.005DOI Listing
February 2019

Letter to the editor, "Fibromyalgia Criteria".

Authors:
Frederick Wolfe

J Pain 2019 Feb 11. Epub 2019 Feb 11.

National Data Bank for Rheumatic Diseases; University of Kansas School of Medicine - Wichita 1035 N. Emporia, Ste 288, Wichita, KS 67214. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2019.02.002DOI Listing
February 2019

Introduction to a new Special Series for the Journal of Pain and Symptom Management - Science in Action: Evidence and opportunities for palliative care across diverse populations and care settings.

J Pain Symptom Manage 2019 Feb 11. Epub 2019 Feb 11.

Director of Quality and Research, American Academy of Hospice and Palliative Medicine (AAHPM), Chicago, IL.

Practices to optimize palliative care delivery and new opportunities in which to integrate palliative care vary across populations and care settings. Systematic reviews are an efficient and methodologically rigorous approach to summarize existing research to identify both evidence-based best-practices as well as new areas for future research and clinical practice. This is the introduction to a special series of articles in which members of the AAHPM Research Committee report the results of circumscribed systematic reviews which in a specific population or care setting seek to: (a) summarize existing evidence for optimal palliative care practices or (b) identify opportunities where better palliative care delivery could improve patient and/or family outcomes. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.005DOI Listing
February 2019

Imbalance between Excitatory and Inhibitory Synaptic Transmission in the Primary Somatosensory Cortex Caused by Persistent Nociception in rats.

J Pain 2019 Feb 8. Epub 2019 Feb 8.

Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, PR China. Electronic address:

There is substantial evidence supporting the notion that the primary somatosensory (S1) cortex is an important structure involved in the perceptional component of pain. However, investigations have mainly focused on other pain-related formations, and few reports have been provided to investigate the synaptic plasticity in the S1 cortex in response to persistent pain. In the present study, we report that bee venom (BV) injection triggered an imbalance between excitatory and inhibitory synaptic transmission in the S1 cortex in rats. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.014DOI Listing
February 2019

Pain-Relief as a Motivation for Cannabis Use among Young Adult Users with and without Chronic Pain.

J Pain 2019 Feb 5. Epub 2019 Feb 5.

Washington State University, Translational Addiction Research Center at WSU.

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http://dx.doi.org/10.1016/j.jpain.2019.02.001DOI Listing
February 2019

Congenital Insensitivity to Pain - A Misnomer.

J Pain 2019 Feb 1. Epub 2019 Feb 1.

Spinal Research Laboratory, Department of Physical Therapy, Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Israel.

"Congenital insensitivity to pain (CIP)" is an umbrella term used to describe a group of rare genetic diseases also classified as "Hereditary Sensory Autonomic Neuropathies (HSAN)". These are intriguing conditions with potential to shed light on the poorly understood relationship concerning nociception and the experience of pain. However, the term CIP is epistemologically incorrect and is the product of historical circumstances. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.331DOI Listing
February 2019

Differences in neuronal representation of mental rotation in CRPS patients and healthy controls.

J Pain 2019 Jan 30. Epub 2019 Jan 30.

Functional Imaging Unit, Center for Diagnostic Radiology, University of Greifswald, Germany. Electronic address:

Spatial integration of parts of the body is impaired in patients with complex regional pain syndrome (CRPS). Since the training of mental rotation (MR) has been shown to be among the effective therapy strategies for CRPS, impairment of MR is also important for the pathophysiological understanding of CRPS. The aim of this study was to evaluate whether differences in neural representation of MR occur between CRPS patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.330DOI Listing
January 2019
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Blockade of NMDA receptors and nitric oxide synthesis potentiated morphine-induced anti-allodynia via attenuating pain-related amygdala pCREB/CREB signaling pathway.

J Pain 2019 Jan 29. Epub 2019 Jan 29.

Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran. Electronic address:

The present study investigated the role of the amygdala NMDA receptors/NOS pathway in morphine-induced anti-allodynia. Concurrently with the bilateral cannulation of the central amygdala (CeA), chronic constriction of the sciatic nerve was performed on male Wistar rats. Morphine (3-5 mg/kg) was intraperitoneally administered to induce anti-allodynia. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.329DOI Listing
January 2019

Pills to Pot: Observational Analyses of Cannabis Substitution Among Medical Cannabis Users With Chronic Pain.

J Pain 2019 Jan 26. Epub 2019 Jan 26.

Anesthesiology Department, University of Michigan Medical School, Ann Arbor, Michigan.

Chronic pain is common, costly, and challenging to treat. Many individuals with chronic pain have turned to cannabis as an alternative form of pain management. We report results from an ongoing, online survey of medical cannabis users with chronic pain nationwide about how cannabis affects pain management, health, and pain medication use. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.010DOI Listing
January 2019

Development of the Revised Opioid Risk Tool to Predict Opioid Use Disorder in Patients with Chronic Non-Malignant Pain.

J Pain 2019 Jan 25. Epub 2019 Jan 25.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

The opioid risk tool (ORT) is a commonly employed measure of risk of aberrant drug related behaviors (ADRB) in patients with chronic pain prescribed opioid therapy. In this study the discriminant predictive validity of the ORT was evaluated in a unique cohort of patients with chronic nonmalignant pain (CNMP) on long-term opioid therapy (LTOT) that displayed no evidence of developing an opioid use disorder (OUD) and a sample of patients with CNMP that developed an OUD after commencing opioid therapy. Results revealed that the original ORT was able to discriminate between patients with and without OUDs (OR=1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183062
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http://dx.doi.org/10.1016/j.jpain.2019.01.011DOI Listing
January 2019
4 Reads

Impact of Sequential Opioid Dose Reduction Interventions in a State Medicaid Program between 2002 and 2017.

J Pain 2019 Jan 25. Epub 2019 Jan 25.

University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA.

Policies that address opioid dose limits may help reduce high-risk opioid prescribing. We evaluated three sequential and progressive decreases in high dose (HD) opioid limits implemented by Massachusetts Medicaid over 15 years. The study population included members ages 18-64 years with ≥1 claim for a schedule II opioid between January 2002 and March 2017. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.008DOI Listing
January 2019

Reward for pain. Hyperalgesia and allodynia induced by operant conditioning: systematic review and meta-analysis.

J Pain 2019 Jan 25. Epub 2019 Jan 25.

Pain Research Group, Institute of Psychology, Jagiellonian University, Kraków, Poland.

Learning processes have been discussed in the context of pain chronicity for decades. Particularly, operant conditioning has been used to experimentally induce and modulate pain in healthy humans. In this systematic review and meta-analysis, research findings on pain facilitation (hyperalgesic effect) and pain elicitation (allodynic effect) are evaluated. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.009DOI Listing
January 2019
2 Reads

Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1.

J Pain 2019 Jan 17. Epub 2019 Jan 17.

Department of Anesthesiology, Maternal and Child Hospital of Hunan Province, Changsha, Hunan 410008, China. Electronic address:

It is widely accepted that neuroinflammation in the spinal cord contribute to the development of central sensitization in neuropathic pain. MAPKs activation plays an vital role in the development of neuroinflammation in the spinal cord. In this study, we investigated the effect of bexarotene, a RXR agonist, on MAPKs activation in CCI-induced neuropathic pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.007DOI Listing
January 2019

Sensorimotor Cortical Activity in Acute Low Back Pain: A Cross-Sectional Study.

J Pain 2019 Jan 17. Epub 2019 Jan 17.

Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.. Electronic address:

Sensorimotor cortical activity is altered in both the immediate acute and chronic stages of musculoskeletal pain. However, these changes are opposite, with decreased cortical activity reported in experimentally induced acute pain (lasting minutes to hours), and increased cortical activity in chronic, clinical pain (lasting >6 months). It is unknown whether sensorimotor cortical activity is altered in acute, clinical musculoskeletal pain (lasting <4 weeks). Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.006DOI Listing
January 2019

Nicotine Evoked Currents in Human Primary Sensory Neurons.

J Pain 2019 Jan 17. Epub 2019 Jan 17.

Department of Anesthesiology; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

Sensory neuron nicotinic acetylcholine receptors (nAChRs) contribute to pain associated with tissue injury. However, there are marked differences between rats and mice with respect to both the properties and distribution of nAChR currents in sensory neurons. Because both species are used to understand pain signaling in humans, we sought to determine whether the currents present in either species was reflective of those present in human sensory neurons. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.005DOI Listing
January 2019

Eighteen-Year Trends in the Prevalence of, and Health Care Use for, Noncancer Pain in the United States: Data from the Medical Expenditure Panel Survey.

J Pain 2019 Jan 15. Epub 2019 Jan 15.

Yale University School of Medicine, Yale Center for Medical Informatics, New Haven Connecticut; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; University of Maryland Baltimore School of Medicine, Center for Integrative Medicine, Baltimore, Maryland.

We used data from the nationally representative Medical Expenditure Panel Survey to determine the 18-year trends in the overall rates of noncancer pain prevalence and pain-related interference, as well as in health care use attributable directly to pain management. The proportion of adults reporting painful health condition(s) increased from 32.9% (99. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183048
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http://dx.doi.org/10.1016/j.jpain.2019.01.003DOI Listing
January 2019
7 Reads

Discrete Trajectories of Resolving and Persistent Pain in People With Rheumatoid Arthritis Despite Undergoing Treatment for Inflammation: Results From Three UK Cohorts.

J Pain 2019 Jan 15. Epub 2019 Jan 15.

Arthritis Research UK Pain Centre and NIHR Nottingham Biomedical Research Centre, and; Division of ROD, University of Nottingham, Nottingham, UK; Department of Rheumatology, Sherwood Forest Hospitals NHS Foundation Trust, Sutton in Ashfield, UK; Nottingham University Hospitals NHS Trust, Nottingham, UK.

Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesized that discrete RA subgroups might display favorable or unfavorable pain trajectories when receiving treatment, and that baseline characteristics will predict trajectory allocation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183047
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http://dx.doi.org/10.1016/j.jpain.2019.01.001DOI Listing
January 2019
6 Reads

The (Parental) Whole Is Greater Than the Sum of Its Parts: A Multifactorial Model of Parent Factors in Pediatric Chronic Pain.

J Pain 2019 Jan 16. Epub 2019 Jan 16.

Department of Psychology, University of Calgary and Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada. Electronic address:

Parents play a critical role in children's experience of, and recovery from, chronic pain. Although several parental factors have been linked to child pain and functioning, these factors are typically examined in isolation or as moderators or mediators. Structural equation modeling affords the opportunity to examine the extent to which parental factors are interrelated, and if there are differential associations among parental factors and child outcomes. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.004DOI Listing
January 2019

Fetal pain debate may weaken the fight for newborns' analgesia.

J Pain 2019 Jan 11. Epub 2019 Jan 11.

Department of Pediatrics University Hospital of Siena, Siena. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2018.12.004DOI Listing
January 2019
1 Read

Facial Features Underlying the Decoding of Pain Expressions.

J Pain 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychoeducation and Psychology, University of Québec in Outaouais, Canada. Electronic address:

Previous research has revealed that the face is a finely tuned medium for pain communication. Studies assessing the decoding of facial expressions of pain have revealed an interesting discrepancy, namely that, despite eyes narrowing being the most frequent facial expression accompanying pain, individuals mostly rely on brow lowering and nose wrinkling/upper lip raising to evaluate pain. The present study verifies if this discrepancy may reflect an interaction between the features coding pain expressions and the features used by observers and stored in their mental representations. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.002DOI Listing
January 2019

Enrichment of Genomic Pathways Based on Differential DNA Methylation Associated With Chronic Postsurgical Pain and Anxiety in Children: A Prospective, Pilot Study.

J Pain 2019 Jan 9. Epub 2019 Jan 9.

Department of Environmental Health, University of Cincinnati; Division of Asthma Research, Cincinnati Children's Hospital, Cincinnati, Ohio.

We have reported child anxiety sensitivity (Child Anxiety Sensitivity Index [CASI]) predicts chronic postsurgical pain (CPSP). Herein, we evaluated DNA methylation profiles to understand the gene-environment interactions underlying CPSP and CASI, to identify shared, enriched, genomic pathways. In 73 prospectively recruited adolescents undergoing spine fusion, preoperative CASI and pain data over 12 months after surgery were collected. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.12.008DOI Listing
January 2019

The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Diagnostic Criteria for Acute Pain Conditions: An Introduction.

J Pain 2019 Jan 10. Epub 2019 Jan 10.

University of Rochester Medical Center, School of Medicine and Dentistry.

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http://dx.doi.org/10.1016/j.jpain.2018.12.002DOI Listing
January 2019

Effectiveness of Opioids for Chronic Noncancer Pain: A Two-Year Multicenter, Prospective Cohort Study With Propensity Score Matching.

J Pain 2018 Dec 29. Epub 2018 Dec 29.

CINTESIS, Center for Health Technology and Services Research, Faculdade de Medicina da Universidade do Porto; MEDCIDS, Departamento de Medicina da Comunidade Informação e Decisão em Saúde, Faculdade de Medicina da Universidade do Porto; Alameda Prof. Hernâni Monteiro, Porto, Portugal; Centro Nacional de Observação em Dor, OBSERVDOR, Porto, Portugal.

Opioid use in chronic non cancer pain (CNCP) is still controversial regarding their effectiveness and safety. We conducted a 2-year prospective cohort study in 4 multidisciplinary chronic pain clinics to assess long-term opioid effectiveness in CNCP patients. All adult CNCP patients consecutively admitted to their first consultation were recruited. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.12.007DOI Listing
December 2018

Do Pain Measurement Instruments Detect the Effect of Pain-Reducing Interventions in Neonates? A Systematic Review on Responsiveness.

J Pain 2018 Dec 23. Epub 2018 Dec 23.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

The effectiveness of pain-reducing interventions in newborns can only be determined if pain measurement instruments are responsive; that is, able to detect a decrease in pain intensity after the pain-reducing intervention. This review assesses the methodologic quality of studies on this measurement property-the responsiveness. We searched the literature published until January 2018 for validation studies of pain measurement instruments focusing on responsiveness to pain-reducing treatment in neonates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183102
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http://dx.doi.org/10.1016/j.jpain.2018.12.005DOI Listing
December 2018
14 Reads

Combination Drug Therapy for the Management of Low Back Pain and Sciatica: Systematic Review and Meta-Analysis.

J Pain 2019 Jan 3;20(1):1-15. Epub 2018 Jul 3.

Sydney School of Public Health, University of Sydney and Institute for Musculoskeletal Health, Sydney, Australia.

Combining medicines may give greater pain relief and/or improved tolerability. We conducted a systematic review to investigate the effects of combination drug therapy in patients with low back pain and/or sciatica on pain, disability, and adverse events. Databases and trial registers were searched from inception to July 27, 2017, for randomized trials of (sub)acute or chronic back pain or sciatica participants that were administered combination drug therapy compared with monotherapy or placebo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183031
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http://dx.doi.org/10.1016/j.jpain.2018.06.005DOI Listing
January 2019
5 Reads

Social Influences on Peer Judgments about Chronic Pain and Disability.

J Pain 2018 Dec 21. Epub 2018 Dec 21.

Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, IN.. Electronic address:

Chronic pain is a leading cause of work absenteeism and disability compensation. Previous work demonstrates that patients with chronic illness often seek advice, such as whether or not to pursue disability benefits, from peers with similar health conditions. The current study examined the extent that social factors influence patients with chronic pain ("peers") when making disability judgments and recommendations for other patients with chronic pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.12.006DOI Listing
December 2018

Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks-American Pain Society-American Academy of Pain Medicine Pain Taxonomy Diagnostic Criteria for Acute Sickle Cell Disease Pain.

J Pain 2018 Dec 19. Epub 2018 Dec 19.

WTZ Department of Pediatrics, Connecticut Children's Medical Center, Hartford, Connecticut.

Acute pain episodes are the most common complication in patients with sickle cell disease (SCD). Classically attributed to vaso-occlusion, recent insights suggest that chronic pain may also contribute to the pathogenesis of acute pain episodes, which adds complexity to their diagnosis and management. A taxonomy, or classification system, for acute pain in patients with SCD would aid research efforts and enhance clinical care. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183101
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http://dx.doi.org/10.1016/j.jpain.2018.12.003DOI Listing
December 2018
11 Reads

Decreasing Pain Ratings in Chronic Arm Pain Through Changing a Virtual Body: Different Strategies for Different Pain Types.

J Pain 2018 Dec 16. Epub 2018 Dec 16.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Event-Lab, Department of Clinical Psychology and Psychobiology, Universitat de Barcelona, Barcelona, Spain; ICREA, Barcelona, Spain; Departamento de Psicología Básica, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Modifying the visual aspect of a virtual arm that is felt as one's own using immersive virtual reality (VR) modifies pain threshold in healthy subjects, but does it modify pain ratings in chronic pain patients? Our aim was to investigate whether varying properties of a virtual arm co-located with the real arm modulated pain ratings in patients with chronic arm/hand pain because of complex regional pain syndrome (CRPS) type I (without nerve injury) or peripheral nerve injury (PNI). CRPS (n = 9) and PNI (n = 10) patients were immersed in VR and the virtual arm was shown at 4 transparency levels (transparency test) and 3 sizes (size test). We evaluated pain ratings throughout the conditions and assessed the virtual experience, finding that patients with chronic pain can achieve levels of ownership and agency over a virtual arm similar to healthy participants. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.12.001DOI Listing
December 2018

Racial-Ethnic Differences in Osteoarthritis Pain and Disability: A Meta-Analysis.

J Pain 2018 Dec 10. Epub 2018 Dec 10.

Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, Florida.

Osteoarthritis (OA), a leading cause of disability and pain, affects 32.5 million Americans, producing tremendous economic burden. Although some findings suggest that racial/ethnic minorities experience increased OA pain severity, other studies have shown conflicting results. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183096
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http://dx.doi.org/10.1016/j.jpain.2018.11.012DOI Listing
December 2018
5 Reads

The Pain Dynamics of Small Fiber Neuropathy.

J Pain 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurology, Maastricht University Medical Center+, 6202 AZ Maastricht, the Netherlands. Electronic address:

Pain is a central feature in small fiber neuropathy (SFN), with only moderate effects of pharmacologic treatment. The evaluation of the efficacy of therapies on pain has been driven by static measures, and a circadian cycle has been suggested. The aim of this study is to evaluate the pain dynamics in SFN. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.009DOI Listing
December 2018

Differential Predictors of Pain Severity Over 12 Months Following Noncatastrophic Injury Sustained in a Road Traffic Crash.

J Pain 2018 Dec 7. Epub 2018 Dec 7.

John Walsh Centre for Rehabilitation Research, Sydney Medical School, Kolling Medical Research Institute, University of Sydney, Sydney, Australia.

There is paucity of prospective studies that have examined rates and prognostic indicators of pain severity after a road traffic crash injury. This cohort study involved 1,854 participants aged ≥17 years with a noncatastrophic injury. Primary analyses of pain severity involved 1604 individuals who reported any pain since the injury at baseline Of these, 1,188 and 972 participants were reexamined at the 6- and 12-month follow-up, respectively. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.011DOI Listing
December 2018
4 Reads

Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats.

J Pain 2018 Dec 8. Epub 2018 Dec 8.

Department of Anesthesiology, Gunma University Graduate School of Medicine, Gunma, Japan.

A rat model of neuropathic pain at 6 weeks after spinal nerve ligation (SNL6w) exhibits both mechanical hypersensitivity and impaired noxious stimuli-induced analgesia (NSIA). Repeated treatment with antidepressants can produce antihypersensitivity and restore NSIA. To examine the involvement of a brain-derived neurotrophic factor-mediated mechanism, a tropomyosin receptor kinase B (TrkB) agonist, 7,8-dihydroxyflavone (DHF), was administered to SNL6w rats (5 mg/kg/d for 5 days). Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.008DOI Listing
December 2018

Comparative Responsiveness of the PROMIS Pain Interference Short Forms With Legacy Pain Measures: Results From Three Randomized Clinical Trials.

J Pain 2018 Dec 6. Epub 2018 Dec 6.

Indiana University School of Medicine, Indianapolis, Indiana.

The Patient-Reported Outcomes Measurement Information System Pain Interference (PROMIS-PI) scales are reliable and publicly accessible; however, little is known about how responsive they are to detect change in clinical trials and how their responsiveness compares with legacy measures. The study purpose was to evaluate responsiveness for the PROMIS-PI scales and to compare their responsiveness with legacy pain measures. We used data from 3 clinical trials totaling 759 participants. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.010DOI Listing
December 2018
1 Read

AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders.

J Pain 2018 Dec 4. Epub 2018 Dec 4.

Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO.

Peripheral neuropathic pain is among the most prevalent types of neuropathic pain. No comprehensive peripheral neuropathic pain classification system that incorporates contemporary clinical, diagnostic, biological, and psychological information exists. To address this need, this article covers the taxonomy for 4 focal or segmental peripheral neuropathic pain disorders, as part of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership and the American Pain Society (APS) collaborative to develop a standardized, evidence-based taxonomy initiative: the ACTTION-APS Pain Taxonomy (AAPT). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183072
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http://dx.doi.org/10.1016/j.jpain.2018.10.002DOI Listing
December 2018
10 Reads

Pan-Canadian Estimates of Chronic Pain Prevalence From 2000 to 2014: A Repeated Cross-Sectional Survey Analysis.

J Pain 2018 Nov 29. Epub 2018 Nov 29.

International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Centre for Clinical Epidemiology and Evaluations, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

Recent temporal trends in the population prevalence of chronic pain in Canada on a national and provincial level are unknown. Five cycles of the Canadian Community Health Survey (2000/2001, 2007/2008, 2009/2010, 2011/2012, and 2013/2014) were used to derive population-based estimates of the self-reported prevalence of chronic pain. Sensitivity analyses examined chronic pain prevalence among those reporting no other chronic health conditions. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.10.010DOI Listing
November 2018
1 Read

Trait Perceived Injustice Is Associated With Pain Intensity and Pain Behavior in Participants Undergoing an Experimental Pain Induction Procedure.

J Pain 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychology, McGill University, Montreal, Quebec, Canada. Electronic address:

Recent research has revealed robust cross-sectional and prospective associations among perceived injustice, pain, disability, and depressive symptoms in patients with chronic pain. To date, research has proceeded from the assumption that perceived injustice arises as a consequence of debilitating injury or illness. However, it is possible that perceived injustice might have trait-like characteristics, persisting even in the absence of an injustice-related eliciting event. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.007DOI Listing
November 2018
1 Read

Enlarged Areas of Pain and Pressure Hypersensitivityby Spatially Distributed Intramuscular Injections ofLow-Dose Nerve Growth Factor.

J Pain 2018 Dec 1. Epub 2018 Dec 1.

Center for Neuroplasticity and Pain (CNAP), SMI. Electronic address:

Intramuscular injection of nerve growth factor (NGF) causes muscle hyperalgesia without immediate pain. This double-blinded, randomized study assessed pain and muscle hypersensitivity after a single-site bolus NGF injection (5 µg) compared with 5 spatially distributed, low-dose NGF injections (1 µg, 4 cm distance) into the tibialis anterior (TA) muscles in 20 healthy subjects. Injection pain was rated on a visual analog scale. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.005DOI Listing
December 2018
3 Reads

Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.

J Pain 2018 Nov 27. Epub 2018 Nov 27.

Department of Anaesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. Electronic address:

Central poststroke pain (CPSP) is a neuropathic pain syndrome arising after a lesion of the central nervous system owing to cerebrovascular insult. Impaired daily activities and reduced quality of life in people suffering from CPSP justify the need for improved treatment. The detailed mechanism of CPSP is not well understood, but central disinhibition has been suggested. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183091
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http://dx.doi.org/10.1016/j.jpain.2018.11.006DOI Listing
November 2018
7 Reads

Trait Mindfulness Is Associated With Lower Pain Reactivity and Connectivity of the Default Mode Network.

J Pain 2018 Nov 27. Epub 2018 Nov 27.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom; Department of Psychology, Queen's University, Kingston, Ontario, Canada. Electronic address:

Mindfulness-based training reduces pain in clinical and experimental settings. Evidence suggests that these beneficial effects are facilitated via an increased focus on the present moment and a reduced emotional enhancement of pain. Most of the existing literature has focused on mindfulness as a learned skill and on the neural mechanisms that underlie the acquisition of this skill. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183091
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http://dx.doi.org/10.1016/j.jpain.2018.10.011DOI Listing
November 2018
15 Reads

Pain Acceptance in Adolescents: Development of a Short Form of the CPAQ-A.

J Pediatr Psychol 2018 Nov 28. Epub 2018 Nov 28.

Bath Centre for Pain Services, Royal United Hospitals Bath, Royal National Hospital for Rheumatic Diseases.

Objective: Acceptance of pain is a predictor of pain-related disability and treatment outcome in adolescents with pain. This variable has been previously measured using the Chronic Pain Acceptance Questionnaire for Adolescents (CPAQ-A, McCracken, Gauntlett-Gilbert, & Eccleston, European Journal of Pain, 14, 316-320, 2010). We set out to create a short, eight-item, form of this instrument that retained its factor structure and clinical utility. Read More

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http://dx.doi.org/10.1093/jpepsy/jsy090DOI Listing
November 2018
9 Reads

Preoperative Psychosocial and Psychophysical Phenotypes as Predictors of Acute Pain Outcomes After Breast Surgery.

J Pain 2018 Nov 23. Epub 2018 Nov 23.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

The severity and impact of acute pain after breast surgery varies markedly among individuals, underlining the importance of comprehensively identifying specific risk factors, including psychosocial and psychophysical traits. In this prospective observational study, women (n = 234) undergoing breast-conserving surgery, mastectomy, or mastectomy with reconstruction completed a brief bedside quantitative sensory testing battery, along with measures of psychosocial characteristics. Postoperative pain severity, impact, and opioid use at 2 weeks were assessed using Brief Pain Inventory and procedure-specific breast cancer pain questionnaires. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.004DOI Listing
November 2018
4 Reads

Incident Chronic Spinal Pain and Depressive Disorders: Data From the National Comorbidity Survey.

J Pain 2018 Nov 22. Epub 2018 Nov 22.

Washington State University, Vancouver, Washington.

This study examined pre-existing depression as a risk factor for the development of chronic spinal pain, and pre-existing chronic spinal pain as a risk factor for the development of depression. Data from the National Comorbidity Survey, a stratified sample of 5,001 participants evaluated in 1990 to 1992 (NCS-1) and again in 2000 to 2001 (NCS-2) were used to address these associations. Cox regression was used to estimate hazard ratios and time-to-incidence after NCS-1. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.002DOI Listing
November 2018
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Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain.

J Pain 2018 Nov 22. Epub 2018 Nov 22.

Department of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, Texas. Electronic address:

Paclitaxel-induced peripheral neuropathy (PIPN) and associated neuropathic pain are the most common and serious adverse effects experienced by cancer patients receiving paclitaxel treatment. These effects adversely impact daily activities and consequently the quality of life, sometimes forcing the suspension of treatment and negatively influencing survival. Patients are usually at high risk of developing PIPN if paclitaxel induces acute pain, which strongly suggests that an acute increase in the excitability of nociceptors underlies the chronic alterations of PIPN. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.001DOI Listing
November 2018
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Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice.

J Pain 2018 Nov 22. Epub 2018 Nov 22.

Department of Anesthesiology, Pain Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling condition accompanying several cancer drugs, including the front-line chemotherapeutic agent paclitaxel. Although CIPN can force dose reduction or even discontinuation of chemotherapy, affecting survival in cancer patients, there is no US Food and Drug Administration-approved treatment for CIPN. CIPN in mice is characterized by neuropathic pain (eg, mechanical allodynia) in association with oxidative stress and neuroinflammation in dorsal root ganglia (DRGs), as well as retraction of intraepidermal nerve fibers. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.003DOI Listing
November 2018
8 Reads

AAPT Diagnostic Criteria for Fibromyalgia.

J Pain 2018 Nov 16. Epub 2018 Nov 16.

Epidemiology Group and Aberdeen Centre for Arthritis and Musculoskeletal Health, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland, United Kingdom.

Fibromyalgia (FM) is a common chronic pain disorder that presents diagnostic challenges for clinicians. Several classification, diagnostic and screening criteria have been developed over the years, but there continues to be a need to develop criteria that reflect the current understanding of FM and are practical for use by clinicians and researchers. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) public-private partnership with the U. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.10.008DOI Listing
November 2018
21 Reads

Influence of Abuse History on Concurrent Benzodiazepine and Opioid Use in Chronic Pain Patients.

J Pain 2018 Nov 16. Epub 2018 Nov 16.

Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan. Electronic address:

An important predictor of opioid overdose is co-use of benzodiazepines, which are often prescribed for anxiety. Coping with anxiety may be particularly difficult among individuals with a history of abuse, as it is often linked to higher pain severity and poorer coping skills. We explored whether abuse history moderated the association between anxiety and benzodiazepine use among current opioid users. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183083
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http://dx.doi.org/10.1016/j.jpain.2018.10.009DOI Listing
November 2018
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Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats.

J Pain 2018 Nov 8. Epub 2018 Nov 8.

Anesthesiology Institute, Cleveland Clinic, and Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. Electronic address:

Paclitaxel induces microglial activation and production of proinflammatory mediators in the dorsal horn, which contribute to the development and maintenance of central sensitization and pain behavior. MDA7, 1-([3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl]carbonyl) piperidine, is a novel highly selective cannabinoid type 2 (CB2) agonist. We tested the hypothesis that activation of CB2 receptor by MDA7 modulates microglial dysregulation, suppresses the overexpression of brain-derived neurotrophic factor (BDNF) in microglia in the dorsal horn, and attenuates the central sensitization and pain behavior induced by paclitaxel. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183079
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http://dx.doi.org/10.1016/j.jpain.2018.10.007DOI Listing
November 2018
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