2,416 results match your criteria Journal of Pain & Palliative Care Pharmacotherapy[Journal]


Heterogeneity of treatment effects in a randomized trial of literacy-adapted group cognitive-behavioral therapy, pain psychoeducation, and usual medical care for multiply disadvantaged patients with chronic pain.

J Pain 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychology, The University of Alabama, Box 870348, Tuscaloosa, AL, 35487-0348, United States of America. Electronic address:

Differences among patients can moderate the impact of evidence-based treatments (i.e., heterogeneity of treatment effects), leading patients to get more or less benefit. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.006DOI Listing

Oxytocin Effects on Pain Perception and Pain Anticipation.

J Pain 2019 Apr 19. Epub 2019 Apr 19.

Department of General Psychiatry, University Hospital of Heidelberg, 69115 Heidelberg.

There is an ongoing debate whether the neuropeptide oxytocin (OT) modulates pain processing in humans. This study differentiates behavioral and neuronal OT effects on pain perception and pain anticipation by using a Pavlovian conditioning paradigm. Forty-six males received intranasally administered OT in a randomized double-blind, placebo-controlled group design. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.002DOI Listing

Desmetramadol has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials.

J Pain 2019 Apr 18. Epub 2019 Apr 18.

Syntrix Pharmaceuticals, Auburn, Washington.

Desmetramadol is an investigational analgesic consisting of (+) and (-) enantiomers of the tramadol metabolite O-desmethyltramadol (M1). Tramadol is racemic and exerts analgesia by monoaminergic effects of (-)-tramadol and (-)-M1, and by the opioid (+)-M1. Tramadol labeling indicates CYP2D6 ultra-metabolizers can produce dangerous (+)-M1 levels, and CYP2D6 poor metabolizers insufficient (+)-M1 for analgesia. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.005DOI Listing

Adverse Childhood Experiences in Mothers with Chronic Pain and Intergenerational Impact on Children.

J Pain 2019 Apr 18. Epub 2019 Apr 18.

Department of Pediatrics, Institute on Development and Disability, Oregon Health & Science University.

Adverse childhood experiences (ACEs; e.g., parental divorce, physical or sexual abuse) are more prevalent in individuals with chronic pain compared to the general population. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.004DOI Listing

Evaluation of post-surgical hyperalgesia and sensitization after open inguinal hernia repair: a useful model for neuropathic pain?

J Pain 2019 Apr 18. Epub 2019 Apr 18.

Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom. Electronic address:

Cutaneous mechanical hyperalgesia can be induced in healthy volunteers in early-phase analgesic studies to model central sensitization, a key mechanism of persistent pain. However, such hyperalgesia is short-lived (a matter of hours), and is used only for assessing only single drug doses. In contrast, post-surgical peri-incisional hyperalgesia may be more persistent, and hence be a more useful model for the assessment of the efficacy of new analgesics. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.012DOI Listing

AAPT Diagnostic Criteria for Chronic Painful Temporomandibular Disorders.

J Pain 2019 Apr 17. Epub 2019 Apr 17.

Departments of Psychiatry and Behavioral Sciences, and Oral Medicine, Schools of Medicine and Dentistry, University of Washington (Emeritus).

The classification of temporomandibular disorders (TMD) has progressed substantially over the past 25 years due to the strategic implementation of an initial classification system based on core taxonomic principles. In this article we describe the development of the DC/TMD and its translation into the multidimensional ACTTION-American Pain Society Pain Taxonomy (AAPT) for chronic pain disorders. The initial scientific classification system (RDC/TMD) relied upon a boot-strapping process that did not attempt to solve all known clinical problems but, rather, focused on problems that could be solved at that time. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.003DOI Listing

Commentary to the paper: The effectiveness of self-management interventions in adults with chronic orofacial pain: A systematic review, Meta-analysis and Meta-regression. European Journal of Pain.

Authors:
M Ferrando

Eur J Pain 2019 Apr 19. Epub 2019 Apr 19.

Kveloce I+D+i Research Consultancy.

The current issue includes a paper by Aggarwal et al (2019), entitled "The effectiveness of self-management interventions in adults with chronic orofacial pain: A Systematic review, Meta-analysis and Meta-regression". The paper is very relevant for both research and evidenced-based practice, since it presents a comprehensive overview of existing published findings on self-management programmes in chronic orofacial pain. This article is protected by copyright. Read More

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http://dx.doi.org/10.1002/ejp.1401DOI Listing

Regular swimming exercise attenuated neuroma pain in rats: involvement of leptin and adiponectin.

J Pain 2019 Apr 12. Epub 2019 Apr 12.

Pain Management Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, CHINA. Electronic address:

Accumulating evidence demonstrates the beneficial effects of physical exercise on pain conditions, however, the underlying mechanisms have not been thoroughly understood. The purpose of the present study was to investigate the effects of regular swimming exercise on neuroma pain and the possible roles of adipokines (leptin and adiponectin) in the pain behaviors modulated by exercise. The results showed that five weeks of regular swimming exercise relieved pain behaviors in a rat model of neuroma pain and normalized the dysregulation of circulating leptin and adiponectin in plasma induced by nerve injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900193069
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http://dx.doi.org/10.1016/j.jpain.2019.02.097DOI Listing
April 2019
5 Reads

Spouse and Patient Beliefs and Perceptions about Chronic Pain: Effects on Couple Interactions and Patient Pain Behavior.

J Pain 2019 Apr 4. Epub 2019 Apr 4.

Duke University Medical Center.

Patients' beliefs and perceptions about the causes and meaning of their chronic pain are related to their psychosocial functioning. Beliefs and perceptions about chronic pain held by spouses may also be related to patient functioning. We used a laboratory procedure to evaluate whether spouse beliefs about and perceptions of chronic pain were related to spouse negative responses toward chronic low back pain patients during a conflictual discussion, and to their attributions about patient pain behavior during a subsequent pain-induction task. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.001DOI Listing
April 2019
1 Read

Measuring stigma in chronic pain: Preliminary investigation of instrument psychometrics, correlates, and magnitude of change in a prospective cohort attending interdisciplinary treatment.

J Pain 2019 Mar 30. Epub 2019 Mar 30.

Health Psychology Section, Psychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London; INPUT Pain Management Unit, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Chronic pain is a potentially stigmatizing condition. However, stigma has received limited empirical investigation in people with chronic pain. Therefore, we examined the psychometric properties of a self-report questionnaire of stigma in people with chronic pain attending interdisciplinary treatment. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.011DOI Listing
March 2019
2 Reads

Painful Temporomandibular Disorder is Associated with Migraine in Adolescents: a case-control study.

J Pain 2019 Mar 29. Epub 2019 Mar 29.

Department of Dental Materials and Prosthodontics, Araraquara School of Dentistry, Univ Estadual Paulista - UNESP, Araraquara, Brazil. Electronic address:

Some types of primary headaches and temporomandibular disorders (TMD) are comorbid in adults and highly prevalent in adolescents. Herein, we investigated the association of painful TMD with specific headache diagnoses (migraine, tension-type headache) and with headache frequency in adolescents. We also explored the association of headache diagnosis with the number of painful sites in the trigeminal area. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.010DOI Listing
March 2019
2 Reads

Interhemispheric Inhibition Is Reduced in Response to Acute Muscle Pain: A Cross-Sectional Study Using Transcranial Magnetic Stimulation.

J Pain 2019 Mar 20. Epub 2019 Mar 20.

Neuroscience Research Australia, Sydney, NSW, Australia. Electronic address:

Bilateral deficits in sensorimotor function have been observed in unilateral musculoskeletal pain conditions. Evidence suggests a reduction in interhemispheric inhibition (IHI) from the "affected" (contralateral to the side of pain) to the "unaffected" primary motor cortex (M1) could contribute. However, the effect of short-lasting acute muscle pain on IHI, and whether any changes are related to early sensorimotor changes in the unaffected limb, is unknown. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.007DOI Listing

Exercise induced hypoalgesia in pain-free and chronic pain populations: State of the art and future directions.

J Pain 2019 Mar 20. Epub 2019 Mar 20.

Pain in Motion International Research Group(#); Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Belgium; Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Belgium; Research Foundation - Flanders (FWO), Brussels, Belgium.

Exercise is considered an important component of effective chronic pain management and it is well established that long term exercise training provides pain relief. In healthy, pain-free populations, a single bout of aerobic or resistance exercise typically leads to exercise induced hypoalgesia (EIH), a generalized reduction in pain and pain sensitivity that occurs during exercise and for some time afterwards. In contrast, EIH is more variable in chronic pain populations and is more frequently impaired; with pain and pain sensitivity decreasing, remaining unchanged or, in some cases, even increasing in response to exercise. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.005DOI Listing
March 2019
3 Reads

Associations Between Catecholaminergic and Serotonergic Genes and Persistent Arm Pain Severity Following Breast Cancer Surgery.

J Pain 2019 Mar 21. Epub 2019 Mar 21.

Schools of Nursing, University of California, San Francisco, California. Electronic address:

Persistent arm pain is a common problem after breast cancer surgery. Little is known about genetic factors that contribute to this type of postsurgical pain. Study purpose was to explore associations between persistent arm pain phenotypes and genetic polymorphisms among 15 genes involved in catecholaminergic and serotonergic neurotransmission. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.008DOI Listing

A definition of flare in low back pain (LBP): A multiphase process involving perspectives of individuals with LBP and expert consensus.

J Pain 2019 Mar 20. Epub 2019 Mar 20.

The University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, QLD, Australia. Electronic address:

Low back pain (LBP) varies over time. Consumers, clinicians and researchers use various terms to describe fluctuations of LBP symptoms. Although "flare" is commonly used to describe symptom fluctuation, there is no consensus on how it is defined. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.009DOI Listing
March 2019
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Diagnostic Uncertainty in Youth With Chronic Pain and Their Parents.

J Pain 2019 Mar 21. Epub 2019 Mar 21.

Department of Psychology, University of Calgary and Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada.

Diagnostic uncertainty-the perception of a lack of or incorrect label to explain symptoms-has been reported by parents of youth with chronic pain. This study was the first to examine diagnostic uncertainty in both youth with chronic pain and their parents using a qualitative methodology. Individual, face-to-face, semistructured interviews were conducted with 20 youth with chronic pain recruited from a pediatric chronic pain program. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.004DOI Listing

Tactile precision remains intact when acute neck pain is induced.

J Pain 2019 Mar 20. Epub 2019 Mar 20.

Laboratory of Pain Research, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland; Department of Orthopaedic and Trauma Surgery, Pain & Exercise Research Luebeck, University of Luebeck, Luebeck, Germany.

A growing body of evidence suggests that chronic pain is associated with perceptual changes, such as impaired tactile acuity and laterality judgements. A recent study on low back pain showed that tactile acuity was reduced immediately after acute pain induction. Biologically, acute pain should lead to enhanced rather than disruptive changes in tactile acuity to meaningfully respond to potentially damaging nociceptive stimuli. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.006DOI Listing
March 2019
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Enhanced Neural Reinstatement for Evoked Facial Pain Compared With Evoked Hand Pain.

J Pain 2019 Mar 20. Epub 2019 Mar 20.

Clinic of Neurology, University Hospital Essen, Essen, Germany; Highfield and Hybrid MR-Imaging, University Hospital Essen, Essen, Germany.

Memory retrieval is accompanied by a reactivation of cortical and subcortical areas that have been active during encoding. This neural reinstatement is stronger during retrieval of pain-associated material compared with other unpleasant events. In this functional magnetic resonance imaging study, we investigated the differences in neural reinstatement during recognition of visual stimuli that had been paired with face or hand pain during memory encoding. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183077
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http://dx.doi.org/10.1016/j.jpain.2019.03.003DOI Listing
March 2019
2 Reads

Are Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?

J Pain 2019 Mar 7. Epub 2019 Mar 7.

NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. Electronic address:

Central sensitization is considered to have a pathophysiological role in chronic low back pain (LBP). Whether individuals with increased central sensitization early in their condition are more likely to develop persistent pain or whether it increases over time is unclear. This study aimed to determine whether sensory profiles during acute LBP differ between individuals who did and did not recover by 6 months and to identify subgroups associated with outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183047
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http://dx.doi.org/10.1016/j.jpain.2019.03.001DOI Listing
March 2019
1 Read

Lack of Antinociceptive Cross-Tolerance With Co-Administration of Morphine and Fentanyl Into the Periaqueductal Gray of Male Sprague-Dawley Rats.

J Pain 2019 Mar 7. Epub 2019 Mar 7.

Department of Psychology, Washington State University, Pullman, Washington.

Tolerance to the antinociceptive effect of mu-opioid receptor agonists, such as morphine and fentanyl, greatly limits their effectiveness for long-term use to treat pain. Clinical studies have shown that combination therapy and opioid rotation can be used to enhance opioid-induced antinociception once tolerance has developed. The mechanism and brain regions involved in these processes are unknown. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.03.002DOI Listing

Perioperative Pregabalin and Intraoperative Lidocaine Infusion to Reduce Persistent Neuropathic Pain After Breast Cancer Surgery: A Multicenter, Factorial, Randomized, Controlled Pilot Trial.

J Pain 2019 Mar 5. Epub 2019 Mar 5.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Persistent postsurgical pain is defined as pain localized to the area of surgery of a duration of ≥2 months and is, unfortunately, a common complication after breast cancer surgery. Although there is insufficient evidence to support any preventative strategy, prior literature suggests the possible efficacy of intravenous lidocaine and perioperative pregabalin in preventing persistent pain after surgery. To determine feasibility of conducting a larger definitive trial, we conducted a multicenter 2 × 2 factorial, randomized, placebo-controlled pilot trial of 100 female patients undergoing breast cancer surgery. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.010DOI Listing
March 2019
2 Reads
4.010 Impact Factor

Pain Neuroscience Education for Adults With Chronic Musculoskeletal Pain: A Mixed-Methods Systematic Review and Meta-Analysis.

J Pain 2019 Mar 1. Epub 2019 Mar 1.

School of Health and Social Care, Teesside University, Middlesbrough, Tees Valley, TS1 3BX, United Kingdom.

Chronic musculoskeletal pain (CMP) is an urgent global public health concern. Pain neuroscience education (PNE) is an intervention used in the management of CMP aiming to reconceptualize an individual's understanding of their pain as less threatening. This mixed-methods review undertook a segregated synthesis of quantitative and qualitative studies to investigate the clinical effectiveness, and patients' experience of, PNE for people with CMP. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.011DOI Listing
March 2019
1 Read

Conditioned Pain Modulation in Sexual Assault Survivors.

J Pain 2019 Feb 27. Epub 2019 Feb 27.

Department of Psychology, The University of Tulsa, Tulsa OK. Electronic address:

Sexual assault (SA) is associated with an increased risk of chronic pain, but the mechanisms for this relationship are poorly understood. To explore whether disrupted descending inhibition is involved, this study used a conditioned pain modulation task to study the inhibition of pain and the nociceptive flexion reflex (NFR; a correlate of spinal nociception) in 32 pain-free SA survivors. This group was compared with 32 pain-free, trauma-exposed persons without SA and a group of 40 pain-free persons who reported no trauma exposure. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.012DOI Listing
February 2019
2 Reads

Response to Wolfe. Letter to the Editor, "Fibromyalgia Criteria".

J Pain 2019 Feb 26. Epub 2019 Feb 26.

Epidemiology Group and Aberdeen Centre for Arthritis and Musculoskeletal Health, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom.

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http://dx.doi.org/10.1016/j.jpain.2019.02.003DOI Listing
February 2019
6 Reads

How an Understanding of Our Ability to Adhere to Verbal Rules Can Increase Insight Into (Mal)adaptive Functioning in Chronic Pain.

J Pain 2019 Feb 27. Epub 2019 Feb 27.

Ghent University, Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium.

Research on chronic pain has traditionally focused on how direct pain experiences lead to maladaptive thoughts, feelings, and actions that set the stage for, and maintain, pain-related disability. Yet the capacity for language (and more specifically verbal instructions or rules) to put people into indirect contact with pain has never been systematically investigated. In this article, we introduce a novel theoretical perspective on verbal processes and discuss how the study of verbal rules may increase our understanding of both maladaptive and adaptive functioning in chronic pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.013DOI Listing
February 2019

Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway.

J Pain 2019 Feb 23. Epub 2019 Feb 23.

Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri. Electronic address:

Sphingosine-1-phosphate (S1P) receptor 1 subtype (S1PR1) activation by its ligand S1P in the dorsal horn of the spinal cord causes mechanohypersensitivity. The cellular and molecular pathways remain poorly understood. We report that the activation of S1PR1 with an intrathecal injection of the highly selective S1PR1 agonist SEW2871 led to the development of mechanoallodynia by activating the nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome (increased expression of NLRP3, cleaved caspase 1 and mature IL-1β) in the dorsal horn of the spinal cord. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.007DOI Listing
February 2019
1 Read

Sensory, Affective, and Catastrophizing Reactions to Multiple Stimulus Modalities: Results from the Oklahoma Study of Native American Pain Risk.

J Pain 2019 Feb 22. Epub 2019 Feb 22.

The University of Tulsa, Department of Psychology, Tulsa, Oklahoma.

Native Americans (NAs) have a higher prevalence of chronic pain than any other U.S. racial/ethnic group; however, little is known about the mechanisms for this pain disparity. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.009DOI Listing
February 2019

The Role of Perceived Stress and Life Stressors in the Development of Chronic Musculoskeletal Pain Disorders: A Systematic Review.

J Pain 2019 Feb 22. Epub 2019 Feb 22.

School of Science and Health, Western Sydney University, New South Wales, Australia; Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia. Electronic address:

The etiologic role of work-related psychological stress in the development of musculoskeletal pain disorders (MDs) has been systematically investigated. Less clear, however, is the role of perceived stress and life stressors. This review aimed to assess the evidence for an etiologic role of perceived stress and life stressors in the development of chronic MDs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183059
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http://dx.doi.org/10.1016/j.jpain.2019.02.008DOI Listing
February 2019
1 Read

Race/Ethnicity Does Not Moderate the Relationship Between Adverse Life Experiences and Temporal Summation of the Nociceptive Flexion Reflex and Pain: Results From the Oklahoma Study of Native American Pain Risk.

J Pain 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychology, The University of Tulsa, Tulsa, Oklahoma. Electronic address:

Adverse life experiences (ALEs) are associated with hyperalgesia and chronic pain, but the underlying mechanisms are poorly understood. One potential mechanism is hyperexcitability of spinal neurons (ie, central sensitization). Given that Native Americans (NAs) are more likely to have ALEs and to have a higher prevalence of chronic pain, the relationship between ALEs and spinal hyperexcitability might contribute to their pain risk. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.006DOI Listing
February 2019

Systematic Review and Neural Network Analysis to Define Predictive Variables in Implantable Motor Cortex Stimulation to Treat Chronic Intractable Pain.

J Pain 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands; Unit of Functional Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands.

Implantable motor cortex stimulation (iMCS) has been performed for >25 years to treat various intractable pain syndromes. Its effectiveness is highly variable and, although various studies revealed predictive variables, none of these were found repeatedly. This study uses neural network analysis (NNA) to identify predictive factors of iMCS treatment for intractable pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.004DOI Listing
February 2019
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Somatic Symptoms in Pediatric Patients With Chronic Pain: Proposed Clinical Reference Points for the Children's Somatic Symptoms Inventory (Formerly the Children's Somatization Inventory).

J Pain 2019 Feb 13. Epub 2019 Feb 13.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California.

Among youth with chronic pain, elevated somatic symptoms across multiple body systems have been associated with greater emotional distress and functional disability and could represent poor adaptation to pain. The Children's Somatic Symptoms Inventory (formerly the Children's Somatization Inventory) is commonly used to assess somatic symptoms in children. However, no studies have evaluated the clinical usefulness of the measure in the assessment of pediatric patients with chronic pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.005DOI Listing
February 2019
1 Read

Letter to the editor, "Fibromyalgia Criteria".

Authors:
Frederick Wolfe

J Pain 2019 Feb 11. Epub 2019 Feb 11.

National Data Bank for Rheumatic Diseases; University of Kansas School of Medicine - Wichita 1035 N. Emporia, Ste 288, Wichita, KS 67214. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2019.02.002DOI Listing
February 2019
3 Reads

Introduction to a New Special Series for the Journal of Pain and Symptom Management-Science in Action: Evidence and Opportunities for Palliative Care Across Diverse Populations and Care Settings.

J Pain Symptom Manage 2019 Feb 11. Epub 2019 Feb 11.

Director of Quality and Research, American Academy of Hospice and Palliative Medicine (AAHPM), Chicago, Illinois, USA.

Practices to optimize palliative care delivery and new opportunities in which to integrate palliative care vary across populations and care settings. Systematic reviews are an efficient and methodologically rigorous approach to summarize existing research to identify both evidence-based best practices and new areas for future research and clinical practice. This is the introduction to a special series of articles in which members of the American Academy of Hospice and Palliative Medicine Research Committee report the results of circumscribed systematic reviews, which in a specific population or care setting seek to 1) summarize existing evidence for optimal palliative care practices or 2) identify opportunities where better palliative care delivery could improve patient and/or family outcomes. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.005DOI Listing
February 2019

Imbalance Between Excitatory and Inhibitory Synaptic Transmission in the Primary Somatosensory Cortex Caused by Persistent Nociception in Rats.

J Pain 2019 Feb 8. Epub 2019 Feb 8.

Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders, Tangdu Hospital, The Fourth Military Medical University, Xi'an, PR China. Electronic address:

There is substantial evidence supporting the notion that the primary somatosensory (S1) cortex is an important structure involved in the perceptional component of pain. However, investigations have mainly focused on other pain-related formations, and few reports have been provided to investigate the synaptic plasticity in the S1 cortex in response to persistent pain. In the present study, we report that bee venom (BV) injection triggered an imbalance between excitatory and inhibitory synaptic transmission in the S1 cortex in rats. Read More

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http://dx.doi.org/10.1016/j.jpain.2018.11.014DOI Listing
February 2019
3 Reads

Pain Relief as a Motivation for Cannabis Use Among Young Adult Users With and Without Chronic Pain.

J Pain 2019 Feb 6. Epub 2019 Feb 6.

Translational Addiction Research Center at WSU, Washington State University, Vancouver, Washington.

This study aims to determine the rate of chronic pain in a community sample of young adult cannabis users, assess the extent to which pain relief is an important motivation for cannabis use, and explore differences in consumption patterns and problem behaviors between users with and without chronic pain. The study design was cross-sectional. Self-selected community-dwelling young adults (ages 18-29 years; n = 143) who regularly use cannabis completed an online survey. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.001DOI Listing
February 2019

Congenital Insensitivity to Pain: A Misnomer.

J Pain 2019 Feb 2. Epub 2019 Feb 2.

Spinal Research Laboratory, Department of Physical Therapy, Stanley Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Congenital insensitivity to pain is an umbrella term used to describe a group of rare genetic diseases also classified as hereditary sensory autonomic neuropathies. These conditions are intriguing, with the potential to shed light on the poorly understood relationship concerning nociception and the experience of pain. However, the term congenital insensitivity to pain is epistemologically incorrect and is the product of historical circumstances. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.331DOI Listing
February 2019

Differences in Neuronal Representation of Mental Rotation in Patients With Complex Regional Pain Syndrome and Healthy Controls.

J Pain 2019 Jan 31. Epub 2019 Jan 31.

Functional Imaging Unit, Center for Diagnostic Radiology, and. Electronic address:

Spatial integration of parts of the body is impaired in patients with complex regional pain syndrome (CRPS). Because the training of mental rotation (MR) has been shown to be among the effective therapy strategies for CRPS, impairment of MR is also important for the pathophysiological understanding of CRPS. The aim of this study was to evaluate whether differences in the neural representation of MR occur between patients with CRPS and healthy controls (HC). Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.330DOI Listing
January 2019
2 Reads

Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway.

J Pain 2019 Jan 29. Epub 2019 Jan 29.

Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran. Electronic address:

The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia. Concurrently with the bilateral cannulation of the central amygdala, chronic constriction of the sciatic nerve was performed on male Wistar rats. Morphine (3-5 mg/kg) was administered intraperitoneally to induce anti-allodynia. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.329DOI Listing
January 2019

Pills to Pot: Observational Analyses of Cannabis Substitution Among Medical Cannabis Users With Chronic Pain.

J Pain 2019 Jan 26. Epub 2019 Jan 26.

Anesthesiology Department, University of Michigan Medical School, Ann Arbor, Michigan.

Chronic pain is common, costly, and challenging to treat. Many individuals with chronic pain have turned to cannabis as an alternative form of pain management. We report results from an ongoing, online survey of medical cannabis users with chronic pain nationwide about how cannabis affects pain management, health, and pain medication use. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.010DOI Listing
January 2019

Development of the Revised Opioid Risk Tool to Predict Opioid Use Disorder in Patients with Chronic Nonmalignant Pain.

J Pain 2019 Jan 26. Epub 2019 Jan 26.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

The Opioid Risk Tool (ORT) is a commonly used measure of risk of aberrant drug-related behaviors in patients with chronic pain prescribed opioid therapy. In this study, the discriminant predictive validity of the ORT was evaluated in a unique cohort of patients with chronic nonmalignant pain (CNMP) on long-term opioid therapy who displayed no evidence of developing an opioid use disorder (OUD) and a sample of patients with CNMP who developed an OUD after commencing opioid therapy. Results revealed that the original ORT was able to discriminate between patients with and without OUDs (odds ratio = 1. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.011DOI Listing
January 2019
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Impact of Sequential Opioid Dose Reduction Interventions in a State Medicaid Program Between 2002 and 2017.

J Pain 2019 Jan 26. Epub 2019 Jan 26.

Commonwealth Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.

Policies that address opioid dose limits may help to decrease high-risk opioid prescribing. We evaluated 3 sequential and progressive decreases in high-dose (HD) opioid limits implemented by Massachusetts Medicaid over 15 years. The study population included members ages 18 to 64 years with ≥1 claim for a schedule II opioid between January 2002 and March 2017. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.008DOI Listing
January 2019
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Reward for Pain: Hyperalgesia and Allodynia Induced by Operant Conditioning: Systematic Review and Meta-Analysis.

J Pain 2019 Jan 25. Epub 2019 Jan 25.

Pain Research Group, Institute of Psychology, Jagiellonian University, Kraków, Poland.

Learning processes have been discussed in the context of pain chronicity for decades. Particularly, operant conditioning has been used to experimentally induce and modulate pain in healthy humans. In this systematic review and meta-analysis, research findings on pain facilitation (hyperalgesic effect) and pain elicitation (allodynic effect) are evaluated. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.009DOI Listing
January 2019
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Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1.

J Pain 2019 Jan 17. Epub 2019 Jan 17.

Department of Anesthesiology, Maternal and Child Hospital of Hunan Province, Changsha, Hunan 410008, China. Electronic address:

It is widely accepted that neuroinflammation in the spinal cord contribute to the development of central sensitization in neuropathic pain. MAPKs activation plays an vital role in the development of neuroinflammation in the spinal cord. In this study, we investigated the effect of bexarotene, a RXR agonist, on MAPKs activation in CCI-induced neuropathic pain. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.007DOI Listing
January 2019
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Sensorimotor Cortical Activity in Acute Low Back Pain: A Cross-Sectional Study.

J Pain 2019 Jan 17. Epub 2019 Jan 17.

Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.. Electronic address:

Sensorimotor cortical activity is altered in both the immediate acute and chronic stages of musculoskeletal pain. However, these changes are opposite, with decreased cortical activity reported in experimentally induced acute pain (lasting minutes to hours), and increased cortical activity in chronic, clinical pain (lasting >6 months). It is unknown whether sensorimotor cortical activity is altered in acute, clinical musculoskeletal pain (lasting <4 weeks). Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.006DOI Listing
January 2019
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Nicotine Evoked Currents in Human Primary Sensory Neurons.

J Pain 2019 Jan 17. Epub 2019 Jan 17.

Department of Anesthesiology; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

Sensory neuron nicotinic acetylcholine receptors (nAChRs) contribute to pain associated with tissue injury. However, there are marked differences between rats and mice with respect to both the properties and distribution of nAChR currents in sensory neurons. Because both species are used to understand pain signaling in humans, we sought to determine whether the currents present in either species was reflective of those present in human sensory neurons. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.01.005DOI Listing
January 2019
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Eighteen-Year Trends in the Prevalence of, and Health Care Use for, Noncancer Pain in the United States: Data from the Medical Expenditure Panel Survey.

J Pain 2019 Jan 15. Epub 2019 Jan 15.

Yale University School of Medicine, Yale Center for Medical Informatics, New Haven Connecticut; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; University of Maryland Baltimore School of Medicine, Center for Integrative Medicine, Baltimore, Maryland.

We used data from the nationally representative Medical Expenditure Panel Survey to determine the 18-year trends in the overall rates of noncancer pain prevalence and pain-related interference, as well as in health care use attributable directly to pain management. The proportion of adults reporting painful health condition(s) increased from 32.9% (99. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183048
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http://dx.doi.org/10.1016/j.jpain.2019.01.003DOI Listing
January 2019
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Discrete Trajectories of Resolving and Persistent Pain in People With Rheumatoid Arthritis Despite Undergoing Treatment for Inflammation: Results From Three UK Cohorts.

J Pain 2019 Jan 15. Epub 2019 Jan 15.

Arthritis Research UK Pain Centre and NIHR Nottingham Biomedical Research Centre, and; Division of ROD, University of Nottingham, Nottingham, UK; Department of Rheumatology, Sherwood Forest Hospitals NHS Foundation Trust, Sutton in Ashfield, UK; Nottingham University Hospitals NHS Trust, Nottingham, UK.

Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesized that discrete RA subgroups might display favorable or unfavorable pain trajectories when receiving treatment, and that baseline characteristics will predict trajectory allocation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15265900183047
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http://dx.doi.org/10.1016/j.jpain.2019.01.001DOI Listing
January 2019
10 Reads