700 results match your criteria Journal of Ovarian Research [Journal]


Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents.

J Ovarian Res 2019 Feb 15;12(1):18. Epub 2019 Feb 15.

The Division of Cancer Biology and Biologic Therapeutics Center, Department of Radiation Oncology, School of Medicine, Washington University in Saint Louis, 660 South Euclid Avenue, Campus Box 8224, St. Louis, MO, 63110, USA.

Background: Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds has sought to exploit their capacity to induce anti-tumor immunization by configuring immunoregulatory molecule within the CRAd genome. Read More

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http://dx.doi.org/10.1186/s13048-019-0493-5DOI Listing
February 2019

TOP2A as marker of response to pegylated lyposomal doxorubicin (PLD) in epithelial ovarian cancers.

J Ovarian Res 2019 Feb 13;12(1):17. Epub 2019 Feb 13.

Department of Oncology, University of Torino, Torino, Italy.

Objective: Relapsed epithelial ovarian cancer (EOC) is frequently treated with pegylated liposomal doxorubicin (PLD). Unfortunately, most patients do not benefit from treatment. Prediction of response is crucial to optimize PLD use and avoid unnecessary toxicities. Read More

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http://dx.doi.org/10.1186/s13048-019-0492-6DOI Listing
February 2019

Can complete blood count inflammatory parameters in epithelial ovarian cancer contribute to prognosis? - a survival analysis.

J Ovarian Res 2019 Feb 11;12(1):16. Epub 2019 Feb 11.

Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey.

Subjective: The aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).

Method: Two hundred forty four patients that underwent operation with the diagnosis of invasive EOC between 2006 and 2014 were included in the study. The date of operation, date of recurrence and final mortality evaluations were performed for survival analysis. Read More

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http://dx.doi.org/10.1186/s13048-019-0491-7DOI Listing
February 2019

Progesterone reduces cell survival in primary cultures of endometrioid ovarian cancer.

J Ovarian Res 2019 Feb 8;12(1):15. Epub 2019 Feb 8.

Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510, Ciudad de México, Mexico.

Background: Ovarian cancer is the most lethal of all gynecologic malignancies. The relationship between sexual steroids receptors and ovarian cancer progression has been largely evaluated. The presence of progesterone receptors has been associated with an increase of a disease-free period and overall survival in patients with ovarian carcinoma. Read More

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http://dx.doi.org/10.1186/s13048-019-0486-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367846PMC
February 2019
1 Read

Aberrant DNA methylation suppresses expression of estrogen receptor 1 (ESR1) in ovarian endometrioma.

J Ovarian Res 2019 Feb 6;12(1):14. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1-1-1, Ube, 755-8505, Japan.

Background: In ovarian endometriomas (OE), the expression statuses of various steroid hormone receptors are altered compared with their expression statuses in eutopic endometrium (EE). For example, in OE, the expressions of estrogen receptor 1 (ESR1), which encodes ERα, and progesterone receptor (PGR) are downregulated, while the expression of ESR2, which encodes ERβ, is upregulated. The causes of these changes are unclear. Read More

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http://dx.doi.org/10.1186/s13048-019-0489-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364435PMC
February 2019

The ability of whole-body SUVmax in F-18 FDG PET/CT to predict suboptimal cytoreduction during primary debulking surgery for advanced ovarian cancer.

J Ovarian Res 2019 Feb 4;12(1):12. Epub 2019 Feb 4.

Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.

Background: The aim of this study was to (1) evaluate the ability of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters to predict suboptimal cytoreduction and (2) to create a risk model for predicting suboptimal cytoreduction in advanced ovarian cancer. From 2011 to 2015, 51 patients underwent primary cytoreductive surgery for advanced ovarian cancer were enrolled. A residual disease with maximal diameter >  1 cm was considered a suboptimal surgical result. Read More

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http://dx.doi.org/10.1186/s13048-019-0488-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360666PMC
February 2019

Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis.

J Ovarian Res 2019 Feb 4;12(1):13. Epub 2019 Feb 4.

Departamento de Ciências Fisiológicas, Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.

Background: Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndrome, making it important to characterize complementary medicine to attenuate such deleterious effects. Therefore, the aim of this study was to assess the effects of a hydroethanolic extract from Syzigium cumini leaves in female reproductive impairments present in the obesity model of neonatal L-monosodium glutamate injection. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0490-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360653PMC
February 2019
3 Reads

Comparison and analysis of the clinicopathological features of SCEO and ECOM.

J Ovarian Res 2019 Jan 30;12(1):10. Epub 2019 Jan 30.

Department of Gynecology, obstetrics and gynecology hospital, Fudan university, Shanghai, 200,090, China.

Objective: The aim of our study was to evaluate and compare the differences in the clinicopathological variables and overall survival (OS) of synchronous primary cancers of the endometrium and ovary (SCEO) and endometrial cancer with ovarian metastasis (ECOM). In addition, we aimed to determine the characteristics of and effective treatments for patients with SCEO to avoid misdiagnosis and overtreatment.

Materials And Methods: A review of medical records from January 2009 to January 2017 revealed 111 patients with coexisting ovarian and endometrial carcinoma diagnosed at the Obstetrics and Gynecology Hospital of Fudan University. Read More

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http://dx.doi.org/10.1186/s13048-019-0485-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352368PMC
January 2019
1 Read

Correction to: Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system.

J Ovarian Res 2019 Jan 30;12(1):11. Epub 2019 Jan 30.

Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.

AbstractThe original article [1] contains errors in Figs. 6 and 8. The corrected figures can be shown ahead. Read More

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http://dx.doi.org/10.1186/s13048-019-0487-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352327PMC
January 2019
1 Read

Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status.

J Ovarian Res 2019 Jan 28;12(1). Epub 2019 Jan 28.

Department of Health of Woman and Child, Gynecologic Oncology Unit, Catholic University of Sacred Heart, Largo Agostino Gemelli 8, 00168, Rome, Italy.

Epithelial ovarian cancer is the most lethal gynecologic malignancy. In most women, it is diagnosed at an advanced stage, which largely explains the poor prognosis of this malignancy. Germline mutations of the genes BRCA1 and BRCA2, which encode proteins essential for the repair of double-strand DNA breaks through homologous recombination, lead to increased cancer predisposition. Read More

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http://dx.doi.org/10.1186/s13048-019-0484-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348631PMC
January 2019

Low dose human chorionic gonadotropin administration at the time of gonadotropin releasing-hormone agonist trigger versus 35 h later in women at high risk of developing ovarian hyperstimulation syndrome - a prospective randomized double-blind clinical trial.

J Ovarian Res 2019 Jan 26;12(1). Epub 2019 Jan 26.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Center for Advanced Reproductive Services, University of Connecticut School of Medicine, Farmington, CT, 06030, USA.

Background: Ovarian hyperstimulation syndrome remains a serious complication during in vitro fertilization cycles if high dose human chorionic gonadotropin (hCG) is used to trigger ovulation in high responder patients. Though much of this risk is mitigated with trigger using gonadotropin releasing-hormone (GnRH) agonist alone, it may result in lower birth rates. GnRH-agonist trigger and adjuvant low dose hCG has been proposed to improve birth rates, but timing of this hCG support to corpus luteum function has never been fully described. Read More

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http://dx.doi.org/10.1186/s13048-019-0483-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347742PMC
January 2019

Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma.

J Ovarian Res 2019 Jan 24;12(1). Epub 2019 Jan 24.

Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.

Background: Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy, compared with serous carcinoma. Hypoxia inducible factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia and plays an important role in tumor growth, and HIF-1α gene single-nucleotide polymorphisms (SNPs) adversely affect the outcome in some cancers. Read More

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http://dx.doi.org/10.1186/s13048-019-0481-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345011PMC
January 2019
2 Reads

Upregulated expression of serum exosomal miR-375 and miR-1307 enhance the diagnostic power of CA125 for ovarian cancer.

J Ovarian Res 2019 Jan 22;12(1). Epub 2019 Jan 22.

The Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, Jiangsu, China.

Background: Ovarian cancer (OC) is associated with high mortality in gynecological oncology; this is mainly due to the low diagnosis rate. Exosomal miRNA has demonstrated potential as a tumor biomarker. We aimed to explore the diagnostic potential of serum exosomal miR-1307 and miR-375 for OC. Read More

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http://dx.doi.org/10.1186/s13048-018-0477-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341583PMC
January 2019

Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome.

J Ovarian Res 2019 Jan 21;12(1). Epub 2019 Jan 21.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Objective: The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS).

Methods: This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 10 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0480-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340184PMC
January 2019
5 Reads

Overexpression of CCDC69 activates p14/MDM2/p53 pathway and confers cisplatin sensitivity.

J Ovarian Res 2019 Jan 16;12(1). Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.

Objectives: The aim of the study is to explore the relationship between CCDC69 expression and resistance of ovarian cancer cells to cisplatin and reveal the underlying mechanism.

Methods: One hundred thirty five ovarian cancer patients with intact chemo-response information from The Cancer Genome Atlas (TCGA) database were included and analyzed. Stable CCDC69 overexpressing 293 and ovarian cancer A2780 cell lines were established and subjected to examine cell apoptosis and cell cycle distribution using CCK-8 assay and flow cytometry. Read More

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http://dx.doi.org/10.1186/s13048-019-0479-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334460PMC
January 2019

The role of the endocannabinoid system in female reproductive tissues.

J Ovarian Res 2019 Jan 15;12(1). Epub 2019 Jan 15.

Department of Pediatrics, and the Graduate Program in Medical Sciences, McMaster University, 1280 Main Street West, HSC 3N11H, Hamilton, ON, L8S 4K1, Canada.

There has been increasing interest in the role of endocannabinoids as critical modulators of the female reproductive processes. Endocannabinoids are natural ligands of cannabinoid, vanilloid, and peroxisome proliferator-activated receptors. Together with their receptors, enzymes and downstream signaling targets, they form the endocannabinoid system (ECS). Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0478-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332911PMC
January 2019
14 Reads

Recurrent ovarian mixed germ cell tumor with unusual malignant transformation: a case report.

J Ovarian Res 2019 Jan 10;12(1). Epub 2019 Jan 10.

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, 201, Section 2, Shih-Pai Road, Taipei, 112, Taiwan, Republic of China.

Background: The value of this report is the identification of late recurrence with an extremely unusual combination of malignant transformation. In particular, the retroconversion of immature to mature teratoma as well as a somatic-type malignant transformation were both observed postchemotherapeutically in our case.

Case Presentation: We report the case of a 20-year-old girl who completed fertility-sparing surgery and chemotherapy under the diagnosis of ovarian mixed germ cell tumor (immature teratoma and yolk sac tumor) and experienced subsequent recurrence 4 years after a second debulking surgery with a somatic type malignant transformation (teratoma with melanoma and leiomyosarcoma). Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0476-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327407PMC
January 2019
5 Reads

Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets.

J Ovarian Res 2019 Jan 4;12(1). Epub 2019 Jan 4.

The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.

Ovarian cancer remains the most fatal gynecologic malignancy worldwide due to delayed diagnosis as well as recurrence and drug resistance. Thus, the development of new tumor-related molecules with high sensitivity and specificity to replace or supplement existing tools is urgently needed. Cancer-testis antigens (CTAs) are exclusively expressed in normal testis tissues but abundantly found in several types of cancers, including ovarian cancer. Read More

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http://dx.doi.org/10.1186/s13048-018-0475-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318940PMC
January 2019
7 Reads

Diversity of imaging features of ovarian sclerosing stromal tumors on MRI and PET-CT: a case report and literature review.

J Ovarian Res 2018 Dec 20;11(1):101. Epub 2018 Dec 20.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Background: Sclerosing stromal tumors (SST) are rare, benign tumors classified as sex cord stromal tumors. To our knowledge, positron emission tomography with computed tomography (PET-CT) findings of SST have only been described in one report and imaging findings on diffusion-weighted imaging (DWI) have only been described in three reports. Characteristic imaging features of SST on PET-CT and DWI have not yet been identified. Read More

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http://dx.doi.org/10.1186/s13048-018-0473-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302382PMC
December 2018
1 Read

Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature.

J Ovarian Res 2018 Dec 14;11(1):100. Epub 2018 Dec 14.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.

Background: Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal girls and in women younger than 30 years. Although JGCT have different histologic features compared to AGCT, the two types have similar imaging features because they have similar gross appearance. Read More

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http://dx.doi.org/10.1186/s13048-018-0474-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293549PMC
December 2018
2 Reads

Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats.

J Ovarian Res 2018 Nov 26;11(1):99. Epub 2018 Nov 26.

Department of Anatomy, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Ficus deltoidea is one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community to treat various ailments and for maintenance of female reproductive health. The objective of this study is to evaluate the potential protective roles of Ficus deltoidea against BPA-induced toxicity of the pituitary-ovarian axis in pre-pubertal female rats. In this study, four groups of pre-pubertal female Sprague Dawley rats were administered with the followings by oral gavage for a period of six weeks: NC (negative control- treated with vehicle), PC (positive control-treated with BPA at 10 mg/kg/BW), F (treated with Ficus deltoidea at 100 mg/kg/BW, then exposed to BPA at 10 mg/kg/BW) and FC (Ficus deltoidea control - treated with Ficus deltoidea at 100 mg/kg/BW). Read More

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http://dx.doi.org/10.1186/s13048-018-0466-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260867PMC
November 2018
2 Reads
2.428 Impact Factor

Expression of Concern to: Does ovary need D-chiro-inositol?

J Ovarian Res 2018 11 23;11(1):98. Epub 2018 Nov 23.

Obstetrics and Gynecology Department, G. Martino Hospital, Messina, Italy.

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http://dx.doi.org/10.1186/s13048-018-0470-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260655PMC
November 2018

Isolated ovarian tuberculosis in an Immuno- competent woman in the post partum period: case report.

Authors:
Wondimu Gudu

J Ovarian Res 2018 Nov 22;11(1):97. Epub 2018 Nov 22.

Department of Obstetrics & Gynecology, Saint Paul's Hospital Millennium Medical College, P.O.Box 1271, Addis Ababa, Ethiopia.

Background: Pelvic tuberculosis is a rare form of extrapulmonary tuberculosis. It commonly involves the fallopian tubes and the uterus from a lympho-hematogeneous spread. The presentation of pelvic tuberculosis as an isolated ovarian abscess is extremely rare and is reported only twice. Read More

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http://dx.doi.org/10.1186/s13048-018-0472-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249878PMC
November 2018
7 Reads

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women.

J Ovarian Res 2018 Nov 21;11(1):95. Epub 2018 Nov 21.

Department of Obstetrics and Gynecology, The Hebrew University Hadassah Medical Center, Jerusalem, Israel.

Background: It has been shown - mostly in animal models - that circadian clock genes are expressed in granulosa cells and in corpora luteum and might be essential for the ovulatory process and steroidogenesis.

Objective: We sought to investigate which circadian clock genes exist in human granulosa cells and whether their expression and activity decrease during aging of the ovary.

Study Design: Human luteinized granulosa cells were isolated from young (age 18-33) and older (age 39-45) patients who underwent in-vitro fertilization treatment. Read More

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http://dx.doi.org/10.1186/s13048-018-0471-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247686PMC
November 2018

Decrease in preovulatory serum estradiol is a valuable marker for predicting premature ovulation in natural/unstimulated in vitro fertilization cycle.

J Ovarian Res 2018 Nov 21;11(1):96. Epub 2018 Nov 21.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.

Background: Premature ovulation occurs at a high rate in natural-cycle in vitro fertilization (IVF), and cycle cancellation further hampers the overall efficiency of the procedure. While lower levels of estradiol (E2) are observed in preovulatory follicles, it is unclear whether declines in E2 can be used as an effective marker of premature ovulation.

Methods: This retrospective analysis includes 801 natural/unstimulated IVF/ICSI cycles undergoing scheduled ovum pick-up (OPU) and 153 natural/unstimulated IVF/ICSI cycles undergoing emergency OPU at a university IVF center from May 2014 to February 2017. Read More

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http://dx.doi.org/10.1186/s13048-018-0469-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247609PMC
November 2018
7 Reads

Luteolin sensitizes the antitumor effect of cisplatin in drug-resistant ovarian cancer via induction of apoptosis and inhibition of cell migration and invasion.

J Ovarian Res 2018 Nov 19;11(1):93. Epub 2018 Nov 19.

Department of Obstetrics and Gynecology, Jinshan branch of Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.

Luteolin, a polyphenolic flavone, has been demonstrated to exert anti-tumor activity in various cancer types. Cisplatin drug resistance is a major obstacle in the management of ovarian cancer. In the present study, we investigated the chemo-sensitizing effect of luteolin in both cisplatin-resistant ovarian cancer cell line and a mice xenotransplant model. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0468-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241043PMC
November 2018
1 Read

Identification of core genes in ovarian cancer by an integrative meta-analysis.

J Ovarian Res 2018 Nov 19;11(1):94. Epub 2018 Nov 19.

The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330031, People's Republic of China.

Background: Epithelial ovarian cancer is one of the most severe public health threats in women. Since it is still challenging to screen in early stages, identification of core genes that play an essential role in epithelial ovarian cancer initiation and progression is of vital importance.

Results: Seven gene expression datasets (GSE6008, GSE18520, GSE26712, GSE27651, GSE29450, GSE36668, and GSE52037) containing 396 ovarian cancer samples and 54 healthy control samples were analyzed to identify the significant differentially expressed genes (DEGs). Read More

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http://dx.doi.org/10.1186/s13048-018-0467-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240943PMC
November 2018
15 Reads

Diagnostic value of the gynecology imaging reporting and data system (GI-RADS) with the ovarian malignancy marker CA-125 in preoperative adnexal tumor assessment.

J Ovarian Res 2018 Nov 3;11(1):92. Epub 2018 Nov 3.

Clinical Unit of Obstetrics, Women's Disease and Gynecological Oncology, sw. Jozefa 53/59, United District Hospital, Collegium Medicum University of Nicolaus Copernicus in Toruń, Torun, Poland.

Objectives: The purpose of this study is to assess the preoperative evaluation of an adnexal mass using the GI-RADS classification and to verify whether CA-125 measurement can offer any additional benefits to the GI-RADS-based prediction of ovarian tumor malignancy.

Material And Methods: In this study, we assessed a total of 215 women with an adnexal tumor using the GI-RADS classification combined with CA-125 measurement. All adnexal masses underwent histological verification. Read More

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http://dx.doi.org/10.1186/s13048-018-0465-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215357PMC
November 2018
8 Reads

Comparison of stage III mucinous and serous ovarian cancer: a case-control study.

J Ovarian Res 2018 Oct 30;11(1):91. Epub 2018 Oct 30.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, BaskentUniversity, Ankara, Turkey.

Background: The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplatin chemotherapy to those of women with stage III serous epithelial ovarian cancer (EOC) treated in the similar manner.

Methods: We performed a multicenter, retrospective review to identify patients with stage III MOC at seven gynecologic oncology departments in Turkey. Eighty-one women with MOC were included. Read More

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http://dx.doi.org/10.1186/s13048-018-0464-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208168PMC
October 2018
8 Reads

DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway.

J Ovarian Res 2018 Oct 18;11(1):90. Epub 2018 Oct 18.

College of Medicine, Jiaxing University, Jiaxing, 314001, China.

Background: The death-domain-associated protein (DAXX) was originally identified as a protein that binds to the transmembrane death receptor FAS and enhances both FAS-induced and transforming growth factor-β-dependent apoptosis. In a previous study, we found that nude mice injected with DAXX-overexpressing cells (ES-2-DAXX) accumulated large concentrations of first-generation ascites cells (I ascites cells). The role of DAXX in the development of ascites is unknown. Read More

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http://dx.doi.org/10.1186/s13048-018-0462-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193355PMC
October 2018
8 Reads

Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5.

J Ovarian Res 2018 Oct 16;11(1):89. Epub 2018 Oct 16.

Laboratory for Aging and Infertility Research, Northeastern University, Boston, MA, 02115, USA.

Background: Cellular metabolic changes that accompany malignant transformation have been heralded as hallmark features of cancer. However, metabolic signatures between neoplasms can be unique, allowing for distinctions in malignancy, invasion and chemoresistance between cancer types and subtypes. Mitochondria are central metabolic mediators, as cellular bioenergetics veers from oxidative phosphorylation to glycolysis. Read More

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http://dx.doi.org/10.1186/s13048-018-0463-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192357PMC
October 2018
1 Read

Mass spectrometry-based proteomics techniques and their application in ovarian cancer research.

J Ovarian Res 2018 Oct 1;11(1):88. Epub 2018 Oct 1.

Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780, Poznań, Poland.

Ovarian cancer has emerged as one of the leading cause of gynecological malignancies. So far, the measurement of CA125 and HE4 concentrations in blood and transvaginal ultrasound examination are essential ovarian cancer diagnostic methods. However, their sensitivity and specificity are still not sufficient to detect disease at the early stage. Read More

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http://dx.doi.org/10.1186/s13048-018-0460-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166298PMC
October 2018

CT of ovarian cancer: 3D cinematic rendering for preoperative evaluation.

J Ovarian Res 2018 Sep 26;11(1):86. Epub 2018 Sep 26.

Radiology Department, Yunnan Cancer Hospital/The Third Affiliated Hospital of Kunming Medical University, 519# Kunzhou Street, Kunming, 650118, Yunnan, China.

Background: Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (CR) has the potential to depict anatomic details accurately. Read More

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http://dx.doi.org/10.1186/s13048-018-0461-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158831PMC
September 2018
9 Reads

Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence.

J Ovarian Res 2018 Sep 26;11(1):87. Epub 2018 Sep 26.

Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.

Background: Fibroblast growth factor 13 (FGF13) is one of the most highly expressed FGF family members in adult mouse ovary. However, its precise roles in ovarian function remain largely unknown. We sought to evaluate the associations between FGF13 in follicular fluid and oocyte developmental competence in patients with polycystic ovary syndrome (PCOS). Read More

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http://dx.doi.org/10.1186/s13048-018-0455-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158872PMC
September 2018
10 Reads

Prognostic value of various subtypes of extracellular DNA in ovarian cancer patients.

J Ovarian Res 2018 Sep 22;11(1):85. Epub 2018 Sep 22.

2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, Klenova 1, 833 10, Bratislava, Slovak Republic.

Background: Patients with ovarian cancer represent a heterogeneous population with a variable prognosis and response to chemotherapy. Plasma DNA has been shown to have a prognostic value in different types of cancer including ovarian carcinoma. Whether total circulating DNA, which can be assessed much easier without knowing the tumor-specific mutations, has similar informative value is currently unknown. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0459-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196469PMC
September 2018
14 Reads

Assessment of Prostaglandin-Endoperoxide Synthase 2 and Versican gene expression profile from the cumulus cells: association with better in vitro fertilization outcomes.

J Ovarian Res 2018 Sep 21;11(1):84. Epub 2018 Sep 21.

Laboratorio de Investigación y Diagnóstico Molecular, Instituto de Infertilidad y Genética, Ingenes México, Av. IPN 2508, 07360, CDMX, México.

Background: Current methods for determining superior embryo quality (morphological assessment) are unable to compensate for poor pregnancy outcomes. Due to the importance of the cumulus-oocyte complex and the value of cumulus cells (CCs) as markers of embryo health, we determined the association between the CCs gene expression of the Prostaglandin-Endoperoxide Synthase 2 (PTGS2) and Versican (VCAN) with pregnancy.

Methods: One hundred forty-nine women, suffering from infertility and undergoing IVF, were included in this study (age: 29-46 years; BMI = 25. Read More

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http://dx.doi.org/10.1186/s13048-018-0456-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148785PMC
September 2018
2 Reads
2.430 Impact Factor

Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium.

J Ovarian Res 2018 Sep 21;11(1):83. Epub 2018 Sep 21.

Stem Cell Biology Department, ICMR - National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, 400 012, India.

Background: Very small embryonic-like stem cells (VSELs) exist in adult organs, express pluripotent markers and have the ability to differentiate into three germ layers in vitro. Testicular, ovarian and hematopoietic stem/progenitor cells express receptors for follicle stimulating (FSH) and ovarian hormones and are activated by them to undergo proliferation/differentiation. VSELs exist in mouse uterus and are regulated by physiological dose of estradiol (E) & progesterone (P) during endometrial growth, differentiation and regeneration/remodeling. Read More

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http://dx.doi.org/10.1186/s13048-018-0454-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148988PMC
September 2018
2 Reads
2.430 Impact Factor

Non-classical 11β-hydroxylase deficiency caused by compound heterozygous mutations: a case study and literature review.

J Ovarian Res 2018 Sep 17;11(1):82. Epub 2018 Sep 17.

Obstetrics and Gynecology Department of Shengjing hospital, China Medical University, Shenyang, 110001, People's Republic of China.

Background: 11β-hydroxylase deficiency (11OHD) is extremely rare, and reports of non-classical 11OHD are even rarer. Non-classical 11OHD usually presents as premature adrenarche, hyperandrogenism, menstrual disorders, and hypertension. Because the symptoms of non-classical 11OHD are mild, delayed diagnosis or misdiagnosis as polycystic ovary syndrome or primary hypertension is common. Read More

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http://dx.doi.org/10.1186/s13048-018-0450-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139905PMC
September 2018
2 Reads

Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types.

J Ovarian Res 2018 Sep 15;11(1):81. Epub 2018 Sep 15.

Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: microRNAs (miRNAs) stably exist in circulating blood encapsulated in extracellular vesicles such as exosomes; therefore, serum miRNAs have the potential to serve as novel cancer biomarkers. New diagnostic markers to detect high grade serous ovarian cancer (HGSOC) are urgently needed. The aim of this study was to identify miRNAs specific to HGSOC and analyze whether serum miRNA can discriminate HGSOC patients from healthy controls or patients with ovarian malignancies of other histological types. Read More

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http://dx.doi.org/10.1186/s13048-018-0458-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138886PMC
September 2018
6 Reads

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome.

J Ovarian Res 2018 Sep 14;11(1):80. Epub 2018 Sep 14.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran.

Background: The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS. Read More

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http://dx.doi.org/10.1186/s13048-018-0457-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137747PMC
September 2018
4 Reads

Persistent megalocystic ovaries after ovarian hyperstimulation syndrome in a postpartum patient with polycystic ovarian syndrome: a case report.

J Ovarian Res 2018 Sep 10;11(1):79. Epub 2018 Sep 10.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College, Chinese Academy of Medical Science, Beijing, 100730, People's Republic of China.

Background: Ovary enlargement is common in controlled ovarian stimulation, which could continue several months during a successful pregnancy. However, persistent megalocystic ovaries 3 years after ovarian hyperstimulation syndrome (OHSS) were rare. Here we will present you the case and treatment as well as discuss the probable etiology. Read More

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http://dx.doi.org/10.1186/s13048-018-0451-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130071PMC
September 2018
8 Reads

Does a poor-quality embryo have an adverse impact on a good-quality embryo when transferred together?

J Ovarian Res 2018 Sep 4;11(1):78. Epub 2018 Sep 4.

The Reproduction Center, The Third Affiliated Hospital of Zhengzhou University, 7 Kangfuqian Road, Zhengzhou, 450052, Henan, People's Republic of China.

Background: In some in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles, we may consider transferring one poor-quality embryo with one good-quality embryo. Previous studies have indicated that the poor-quality embryo transferred with a good-quality embryo does not negatively affect the clinical pregnancy rate or live birth rate. The purpose of this study was to evaluate pregnancy outcomes and neonatal outcomes in this context. Read More

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http://dx.doi.org/10.1186/s13048-018-0452-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122748PMC
September 2018
4 Reads

Anaplastic carcinoma in ovarian seromucinous cystic tumor of borderline malignancy.

J Ovarian Res 2018 Sep 3;11(1):77. Epub 2018 Sep 3.

Department of Obstetrics and Gynecology, Maruyama Memorial General Hospital, 2-10-5 Motomachi, Iwatukiku, Saitamashi, Saitama, 339-8521, Japan.

Background: The mortality rate of ovarian cancer is the highest among all gynecological malignancies in Japan. Ovarian tumors are classified as benign, borderline malignant, or malignant. Anticipating the histological subtype with imaging only is often difficult because of several histological subtypes of epithelial ovarian tumors (such as serous, mucinous, endometrioid, clear cell, and Brenner tumors). Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0449-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120074PMC
September 2018
13 Reads
2.430 Impact Factor

Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review.

J Ovarian Res 2018 Aug 31;11(1):76. Epub 2018 Aug 31.

Institut Clinic of Gynecology, Obstetrics and Neonatology (ICGON), Barcelona, Spain.

Background: The aim of this report was to describe a case of pregnancy after drug-free in vitro activation (IVA) of follicles and fresh tissue autotransplantation in primary ovarian insufficiency (POI) patient and to review the pertinent literature.

Methods: We present a case in wich a 32 - years old patient with POI became pregnant after IVA without tissue culture and with ovarian tissue transplantation. We also reviewed the literature using Pubmed database. Read More

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http://dx.doi.org/10.1186/s13048-018-0447-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119245PMC
August 2018
1 Read

Ovarian teratoma in children: a plea for collaborative clinical study.

J Ovarian Res 2018 Aug 30;11(1):75. Epub 2018 Aug 30.

Pediatric Surgery and Urology Department, Wroclaw Medical University, 52 M. Sklodowskiej - Curie ST, 50-369, Wroclaw, Poland.

Background: Although teratomas are the most common histologic subtype of childhood ovarian germ cell tumors, their appropriate treatment in this age group still remains unclear. Paucity of research dedicated exclusively to both mature and immature teratomas of the ovary, contribute to decision making difficulties. Therefore, we decided to review retrospectively our experience in treatment of pediatric ovarian teratomas in order to assess the epidemiology, presenting features, and diagnostic as well as surgical management of these lesions. Read More

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http://dx.doi.org/10.1186/s13048-018-0448-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116467PMC
August 2018
1 Read

The value of MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary: emphasis on diffusion-weighted MR imaging.

J Ovarian Res 2018 Aug 30;11(1):73. Epub 2018 Aug 30.

Department of Radiology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Background: To investigate MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary (SCSTs) emphasizing on the value of diffusion-weighted (DW) magnetic resonance (MR) imaging.

Methods: This retrospective study included 29 benign SCSTs in 28 patients and 13 malignant SCSTs in 13 patients. DW imaging as well as conventional MR imaging was performed. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0444-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116557PMC
August 2018
9 Reads

Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary.

J Ovarian Res 2018 Aug 30;11(1):72. Epub 2018 Aug 30.

Center for Reproductive Science, Northwestern University, Chicago, IL, 60611, USA.

Background: Radiation exposure is known to cause accelerated aging and damage to the ovary, but the contribution of indirect versus direct effects is not well understood. We used the Small Animal Radiation Research Platform (SARRP) (Xstrahl) to deliver radiation to precise fields equivalent to clinical practice, allowing us to investigate systemic versus targeted damage in a structure as small as the mouse ovary. The X-ray dose was kept constant at 1 Gy, but the field varied. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0442-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116356PMC
August 2018
7 Reads

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma.

J Ovarian Res 2018 Aug 30;11(1):74. Epub 2018 Aug 30.

Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Background: It is well known that ovarian mature cystic teratomas (MCTs) occasionally go through malignant transformations. Among these, approximately 75% of histological types are squamous cell carcinoma, with the other types being exceptionally rare. We report an extremely rare case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma. Read More

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http://dx.doi.org/10.1186/s13048-018-0446-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116445PMC
August 2018
5 Reads

The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention.

J Ovarian Res 2018 Aug 29;11(1):71. Epub 2018 Aug 29.

Department of Gynecologic Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of vitamin D in ovarian cancer strongly suggest that it exhibits protective and antitumorigenic activities through genomic and nongenomic signal transduction pathways. Read More

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http://dx.doi.org/10.1186/s13048-018-0443-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114234PMC
August 2018
1 Read

Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome.

J Ovarian Res 2018 Aug 27;11(1):70. Epub 2018 Aug 27.

IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam.

Background: In vitro maturation (IVM) has some advantages over conventional in vitro fertilization (IVF), particularly in polycystic ovary syndrome (PCOS) where the risk of ovarian hyperstimulation is high. We studied the live birth rate in a large series of PCOS women undergoing human chorionic gonadotropin (hCG)-priming IVM.

Methods: This retrospective study included women with PCOS aged 18-42 years undergoing IVM with hCG priming. Read More

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http://dx.doi.org/10.1186/s13048-018-0445-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112143PMC
August 2018
2 Reads