716 results match your criteria Journal of Ovarian Research [Journal]


A potential function of RLIP76 in the ovarian corpus luteum.

J Ovarian Res 2019 Apr 18;12(1):34. Epub 2019 Apr 18.

College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea.

Ral interacting protein of 76 kDa (RLIP76) is multifunctional protein localized and distributed in the plasma membrane, cytosol, and nucleus of the cell. In tumorigenesis, RLIP76 emerges as a common feature for the solid tumor growth. RLIP76 is ubiquitously expressed in various tissues including the ovary. Read More

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http://dx.doi.org/10.1186/s13048-019-0510-8DOI Listing

The prognosis impact of hyperthermic intraperitoneal chemotherapy (HIPEC) plus cytoreductive surgery (CRS) in advanced ovarian cancer: the meta-analysis.

J Ovarian Res 2019 Apr 17;12(1):33. Epub 2019 Apr 17.

Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, No.8, industrial south road, Chaoyang District, Beijing, China.

Background And Objective: Previous studies about the prognostic value of the HIPEC have yielded controversial results. Therefore, this study aims to assess the impact of HIPEC on patients with ovarian cancer.

Results: We included 13 comparative studies, and found that the overall survival (OS) and progression-free survival (PFS) in HIPEC groups were superior to groups without HIPEC treatment in the all total population (HR = 0. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0509-1DOI Listing
April 2019
1 Read

A rare case of ovarian carcinosarcoma with squamous cell carcinoma.

J Ovarian Res 2019 Apr 4;12(1):32. Epub 2019 Apr 4.

Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka, 569-8686, Japan.

Background: Ovarian carcinosarcoma, which contains sarcomatous and carcinomatous components, is a very rare tumor. The carcinomatous component is often adenocarcinoma, and squamous cell carcinoma is extremely rare. We herein report a case of ovarian carcinosarcoma in which the carcinomatous component was squamous cell carcinoma. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0507-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449921PMC
April 2019
2 Reads

Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice.

J Ovarian Res 2019 Apr 4;12(1):31. Epub 2019 Apr 4.

Present Address: Department of Obstetrics & Gynecology, Sapporo Medical University, South 1 West 16, Sapporo, Hokkaido, 060-8543, Japan.

Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Read More

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http://dx.doi.org/10.1186/s13048-019-0505-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450008PMC
April 2019
1 Read

Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.

J Ovarian Res 2019 Mar 27;12(1):30. Epub 2019 Mar 27.

Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic.

Background: Increased activity of the chaperones Hsp70 and Hsp90 is a common feature of solid tumours. Translocase of the outer mitochondrial membrane 34 (Tomm34) is a cochaperone of both Hsp70 and Hsp90 that was found to be overexpressed in colorectal, hepatocellular, lung and breast carcinomas. The expression profile of Tomm34 in ovarian cancer has not been investigated. Read More

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http://dx.doi.org/10.1186/s13048-019-0498-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436220PMC
March 2019
1 Read

Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review.

J Ovarian Res 2019 Mar 27;12(1):28. Epub 2019 Mar 27.

Service de Gynécologie-Obstétrique, Centre Hospitalier Départemental Vendée, La Roche sur Yon, France.

Ovarian cancer is the 5th leading cause of death for women with cancer worldwide. In more than 70% of cases, it is only diagnosed at an advanced stage. Our study aims to give an update on the biological markers for diagnosing ovarian cancer, specifically HE4, CA 125, RMI and ROMA algorithms. Read More

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http://dx.doi.org/10.1186/s13048-019-0503-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436208PMC

Postoperative recurrence of epithelial ovarian cancer patients and chemoresistance related protein analyses.

J Ovarian Res 2019 Mar 27;12(1):29. Epub 2019 Mar 27.

Research Center, Fourth Hospital of Hebei Medical University, No.12, Jiankang Road, Shijiazhuang, 050011, China.

Objective: To identify the plasma protein biomarkers related to the chemoresistance of postoperative recurrence of epithelial ovarian cancers.

Methods: Forty plasma samples from patients in chemotherapy-sensitive and chemotherapy-resistant groups (20 for each group) were collected at Gynecology Department in the Fourth Hospital of Hebei Medical University from September 2013 to September 2014. The differentially expressed proteins between two groups were screened with two-dimensional gel electrophoresis (2-DE) and further analyzed by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Read More

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http://dx.doi.org/10.1186/s13048-019-0499-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436226PMC
March 2019
1 Read

Effects of hysterectomy with simultaneous bilateral salpingectomy on the subsequent pelvic mass.

J Ovarian Res 2019 Mar 27;12(1):27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Shuaifuyuan No. 1, Dongcheng District, Beijing, 100730, China.

Objectives: To analyze the clinicopathological characteristics of subsequent pelvic masses after hysterectomy for benign diseases, and to compare the masses following hysterectomy with or without simultaneous bilateral salpingectomy.

Methods: This study retrospectively analyzed patients undergone reoperation for pelvic mass subsequently to previous hysterectomy for benign disease from January 2012 to December 2016 in Peking Union Medical College Hospital.

Results: A total of 247 patients were enrolled in this study, of which 80. Read More

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http://dx.doi.org/10.1186/s13048-019-0504-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436212PMC
March 2019
1 Read

Melatonin is a potential inhibitor of ovarian cancer: molecular aspects.

J Ovarian Res 2019 Mar 26;12(1):26. Epub 2019 Mar 26.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran.

Ovarian cancer is one of the most common causes of morbidity related to gynecologic malignancies. Possible risk factors are including hereditary ovarian cancer, obesity, diabetes mellitus, alcohol consumption, aging, and smoking. Various molecular signaling pathways including inflammation, oxidative stress, apoptosis and angiogenesis are involved in this progression of ovarian cancer. Read More

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http://dx.doi.org/10.1186/s13048-019-0502-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434863PMC

Metabolomic change due to combined treatment with myo-inositol, D-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study.

J Ovarian Res 2019 Mar 23;12(1):25. Epub 2019 Mar 23.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.

Background: Polycystic ovarian syndrome (PCOS) is a highly variable syndrome and one of the most common female endocrine disorders. Although the association inositols-glucomannan may represent a good therapeutic strategy in the treatment of PCOS women with insulin resistance, the effect of inositols on the metabolomic profile of these women has not been described yet.

Results: Fifteen PCOS-patients and 15 controls were enrolled. Read More

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http://dx.doi.org/10.1186/s13048-019-0500-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431025PMC
March 2019
1 Read

Circulating microRNAs as novel potential diagnostic biomarkers for ovarian cancer: a systematic review and updated meta-analysis.

J Ovarian Res 2019 Mar 21;12(1):24. Epub 2019 Mar 21.

Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, 471003, China.

Object: Ovarian cancer is the primary cause of cancer-associated deaths among gynaecological malignancies. Increasing evidence suggests that microRNAs may be potential biomarkers for the diagnosis and prognosis of cancer. In this study, we conducted a systematic review and meta-analysis to summarize the global research and to evaluate the overall diagnostic accuracy of miRNAs in detecting ovarian cancer. Read More

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http://dx.doi.org/10.1186/s13048-019-0482-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427862PMC
March 2019
1 Read

Expression of zinc finger transcription factors (ZNF143 and ZNF281) in serous borderline ovarian tumors and low-grade ovarian cancers.

J Ovarian Res 2019 Mar 18;12(1):23. Epub 2019 Mar 18.

Department of Obstetrics and Gynecology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, ul. Ujejskiego 75, 85-168, Bydgoszcz, Poland.

Low-grade ovarian cancers represent up to 8% of all epithelial ovarian carcinomas (EOCs). Recent studies demonstrated that epithelial-mesenchymal transition (EMT) is crucial for the progression of EOCs. EMT plays a key role in cancer invasion, metastasis formation and chemotherapy resistance. Read More

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http://dx.doi.org/10.1186/s13048-019-0501-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423742PMC
March 2019
1 Read

The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary.

J Ovarian Res 2019 Mar 11;12(1):22. Epub 2019 Mar 11.

Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnóstico -CEBBAD Universidad Maimónides, C1405BCK, Buenos Aires, Argentina.

Background: Normal pubertal ovary displays all stages of follicular development and a biased BAX/BCL2 protein ratio in favor of pro-apoptotic BAX protein comparable to the adult ovary. However, adolescents suffering malignant extra-gonadal disease show a limited follicle development after cytotoxic drug treatment and a reduced capacity of in vitro follicle growth. We evaluated the expression of pro- and anti-apoptotic members of the BCL2 gene family, the FAS/FAS-L proteins from the extrinsic apoptosis pathway, the germ-cell-specific marker VASA, the pluripotency marker OCT3/4, and markers of early and late apoptosis in the ovary of pubertal patients with malignant extra-gonadal disease, which received or not pre-surgery chemotherapy, entering a cryopreservation program. Read More

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http://dx.doi.org/10.1186/s13048-019-0496-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410530PMC
March 2019
1 Read

HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration.

J Ovarian Res 2019 Feb 28;12(1):21. Epub 2019 Feb 28.

IVF Unit and Reproduction Laboratory, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel., 5262100, Tel Hashomer, Israel.

Background: The cumulus expansion process is one of the LH mediated ovulatory processes. Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the main component of the cumulus expansion process. Recently, the lncRNA HAS2 antisense RNA 1 (HAS2-AS1) was identified in our global transcriptome RNA-sequencing of novel ovulation associated genes. Read More

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http://dx.doi.org/10.1186/s13048-019-0495-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396505PMC
February 2019
2 Reads

Magnetic resonance imaging findings for discriminating clear cell carcinoma and endometrioid carcinoma of the ovary.

J Ovarian Res 2019 Feb 25;12(1):20. Epub 2019 Feb 25.

Department of Obstetrics and Gynecology, Nara Medical University, Shijo-cho 840, Kashihara, Nara, 634-8522, Japan.

Background: Common cancerous histological types associated with endometriosis are clear cell carcinoma (CCC) and endometrioid carcinoma (EC). CCC is regarded as an aggressive, chemoresistant histological subtype. Magnetic resonance imaging (MRI) offers some potential advantages to diagnose ovarian tumors compared with ultrasonography or computed tomography. Read More

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http://dx.doi.org/10.1186/s13048-019-0497-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388492PMC
February 2019
1 Read

Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients.

J Ovarian Res 2019 Feb 20;12(1):19. Epub 2019 Feb 20.

School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 1168 Western Chunrong Road, Yuhua Street, Cheng Gong District, Kunming, Yunnan, 650500, People's Republic of China.

Background: Ovarian cancer (OC) is one of the most malignant gynecological tumors, associated with excess death rate (50-60%) in ovarian cancer patients. Particularly, among newly occurred ovarian cancer patients, 70% of clinical cases are diagnosed at the advanced stage, which definitely delay the timely treatment and lead to high mortality rate within 5 years post diagnosis. Therefore, identification of sensitive gene markers, as well as development of reliable genetic diagnosis, are important for the early detection and precise therapy for OC patients. Read More

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http://dx.doi.org/10.1186/s13048-019-0494-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381667PMC
February 2019
2.428 Impact Factor

Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents.

J Ovarian Res 2019 Feb 15;12(1):18. Epub 2019 Feb 15.

The Division of Cancer Biology and Biologic Therapeutics Center, Department of Radiation Oncology, School of Medicine, Washington University in Saint Louis, 660 South Euclid Avenue, Campus Box 8224, St. Louis, MO, 63110, USA.

Background: Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds has sought to exploit their capacity to induce anti-tumor immunization by configuring immunoregulatory molecule within the CRAd genome. Read More

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http://dx.doi.org/10.1186/s13048-019-0493-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376676PMC
February 2019
1 Read

TOP2A as marker of response to pegylated lyposomal doxorubicin (PLD) in epithelial ovarian cancers.

J Ovarian Res 2019 Feb 13;12(1):17. Epub 2019 Feb 13.

Department of Oncology, University of Torino, Torino, Italy.

Objective: Relapsed epithelial ovarian cancer (EOC) is frequently treated with pegylated liposomal doxorubicin (PLD). Unfortunately, most patients do not benefit from treatment. Prediction of response is crucial to optimize PLD use and avoid unnecessary toxicities. Read More

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http://dx.doi.org/10.1186/s13048-019-0492-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373097PMC
February 2019

Can complete blood count inflammatory parameters in epithelial ovarian cancer contribute to prognosis? - a survival analysis.

J Ovarian Res 2019 Feb 11;12(1):16. Epub 2019 Feb 11.

Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey.

Subjective: The aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).

Method: Two hundred forty four patients that underwent operation with the diagnosis of invasive EOC between 2006 and 2014 were included in the study. The date of operation, date of recurrence and final mortality evaluations were performed for survival analysis. Read More

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http://dx.doi.org/10.1186/s13048-019-0491-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371536PMC
February 2019
1 Read

Progesterone reduces cell survival in primary cultures of endometrioid ovarian cancer.

J Ovarian Res 2019 Feb 8;12(1):15. Epub 2019 Feb 8.

Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510, Ciudad de México, Mexico.

Background: Ovarian cancer is the most lethal of all gynecologic malignancies. The relationship between sexual steroids receptors and ovarian cancer progression has been largely evaluated. The presence of progesterone receptors has been associated with an increase of a disease-free period and overall survival in patients with ovarian carcinoma. Read More

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http://dx.doi.org/10.1186/s13048-019-0486-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367846PMC
February 2019
1 Read

Aberrant DNA methylation suppresses expression of estrogen receptor 1 (ESR1) in ovarian endometrioma.

J Ovarian Res 2019 Feb 6;12(1):14. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1-1-1, Ube, 755-8505, Japan.

Background: In ovarian endometriomas (OE), the expression statuses of various steroid hormone receptors are altered compared with their expression statuses in eutopic endometrium (EE). For example, in OE, the expressions of estrogen receptor 1 (ESR1), which encodes ERα, and progesterone receptor (PGR) are downregulated, while the expression of ESR2, which encodes ERβ, is upregulated. The causes of these changes are unclear. Read More

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http://dx.doi.org/10.1186/s13048-019-0489-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364435PMC
February 2019

The ability of whole-body SUVmax in F-18 FDG PET/CT to predict suboptimal cytoreduction during primary debulking surgery for advanced ovarian cancer.

J Ovarian Res 2019 Feb 4;12(1):12. Epub 2019 Feb 4.

Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.

Background: The aim of this study was to (1) evaluate the ability of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters to predict suboptimal cytoreduction and (2) to create a risk model for predicting suboptimal cytoreduction in advanced ovarian cancer. From 2011 to 2015, 51 patients underwent primary cytoreductive surgery for advanced ovarian cancer were enrolled. A residual disease with maximal diameter >  1 cm was considered a suboptimal surgical result. Read More

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http://dx.doi.org/10.1186/s13048-019-0488-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360666PMC
February 2019

Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis.

J Ovarian Res 2019 Feb 4;12(1):13. Epub 2019 Feb 4.

Departamento de Ciências Fisiológicas, Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.

Background: Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndrome, making it important to characterize complementary medicine to attenuate such deleterious effects. Therefore, the aim of this study was to assess the effects of a hydroethanolic extract from Syzigium cumini leaves in female reproductive impairments present in the obesity model of neonatal L-monosodium glutamate injection. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0490-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360653PMC
February 2019
9 Reads

Comparison and analysis of the clinicopathological features of SCEO and ECOM.

J Ovarian Res 2019 Jan 30;12(1):10. Epub 2019 Jan 30.

Department of Gynecology, obstetrics and gynecology hospital, Fudan university, Shanghai, 200,090, China.

Objective: The aim of our study was to evaluate and compare the differences in the clinicopathological variables and overall survival (OS) of synchronous primary cancers of the endometrium and ovary (SCEO) and endometrial cancer with ovarian metastasis (ECOM). In addition, we aimed to determine the characteristics of and effective treatments for patients with SCEO to avoid misdiagnosis and overtreatment.

Materials And Methods: A review of medical records from January 2009 to January 2017 revealed 111 patients with coexisting ovarian and endometrial carcinoma diagnosed at the Obstetrics and Gynecology Hospital of Fudan University. Read More

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http://dx.doi.org/10.1186/s13048-019-0485-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352368PMC
January 2019
2 Reads

Correction to: Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system.

J Ovarian Res 2019 Jan 30;12(1):11. Epub 2019 Jan 30.

Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.

AbstractThe original article [1] contains errors in Figs. 6 and 8. The corrected figures can be shown ahead. Read More

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http://dx.doi.org/10.1186/s13048-019-0487-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352327PMC
January 2019
2 Reads

Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status.

J Ovarian Res 2019 Jan 28;12(1). Epub 2019 Jan 28.

Department of Health of Woman and Child, Gynecologic Oncology Unit, Catholic University of Sacred Heart, Largo Agostino Gemelli 8, 00168, Rome, Italy.

Epithelial ovarian cancer is the most lethal gynecologic malignancy. In most women, it is diagnosed at an advanced stage, which largely explains the poor prognosis of this malignancy. Germline mutations of the genes BRCA1 and BRCA2, which encode proteins essential for the repair of double-strand DNA breaks through homologous recombination, lead to increased cancer predisposition. Read More

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http://dx.doi.org/10.1186/s13048-019-0484-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348631PMC
January 2019
2 Reads

Low dose human chorionic gonadotropin administration at the time of gonadotropin releasing-hormone agonist trigger versus 35 h later in women at high risk of developing ovarian hyperstimulation syndrome - a prospective randomized double-blind clinical trial.

J Ovarian Res 2019 Jan 26;12(1). Epub 2019 Jan 26.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Center for Advanced Reproductive Services, University of Connecticut School of Medicine, Farmington, CT, 06030, USA.

Background: Ovarian hyperstimulation syndrome remains a serious complication during in vitro fertilization cycles if high dose human chorionic gonadotropin (hCG) is used to trigger ovulation in high responder patients. Though much of this risk is mitigated with trigger using gonadotropin releasing-hormone (GnRH) agonist alone, it may result in lower birth rates. GnRH-agonist trigger and adjuvant low dose hCG has been proposed to improve birth rates, but timing of this hCG support to corpus luteum function has never been fully described. Read More

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http://dx.doi.org/10.1186/s13048-019-0483-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347742PMC
January 2019
1 Read

Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma.

J Ovarian Res 2019 Jan 24;12(1). Epub 2019 Jan 24.

Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan.

Background: Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy, compared with serous carcinoma. Hypoxia inducible factor-1α (HIF-1α) is a key regulator of cellular response to hypoxia and plays an important role in tumor growth, and HIF-1α gene single-nucleotide polymorphisms (SNPs) adversely affect the outcome in some cancers. Read More

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http://dx.doi.org/10.1186/s13048-019-0481-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345011PMC
January 2019
2 Reads

Upregulated expression of serum exosomal miR-375 and miR-1307 enhance the diagnostic power of CA125 for ovarian cancer.

J Ovarian Res 2019 Jan 22;12(1). Epub 2019 Jan 22.

The Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, Jiangsu, China.

Background: Ovarian cancer (OC) is associated with high mortality in gynecological oncology; this is mainly due to the low diagnosis rate. Exosomal miRNA has demonstrated potential as a tumor biomarker. We aimed to explore the diagnostic potential of serum exosomal miR-1307 and miR-375 for OC. Read More

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http://dx.doi.org/10.1186/s13048-018-0477-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341583PMC
January 2019
1 Read

Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome.

J Ovarian Res 2019 Jan 21;12(1). Epub 2019 Jan 21.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Objective: The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS).

Methods: This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 10 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0480-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340184PMC
January 2019
8 Reads

Overexpression of CCDC69 activates p14/MDM2/p53 pathway and confers cisplatin sensitivity.

J Ovarian Res 2019 Jan 16;12(1). Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.

Objectives: The aim of the study is to explore the relationship between CCDC69 expression and resistance of ovarian cancer cells to cisplatin and reveal the underlying mechanism.

Methods: One hundred thirty five ovarian cancer patients with intact chemo-response information from The Cancer Genome Atlas (TCGA) database were included and analyzed. Stable CCDC69 overexpressing 293 and ovarian cancer A2780 cell lines were established and subjected to examine cell apoptosis and cell cycle distribution using CCK-8 assay and flow cytometry. Read More

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http://dx.doi.org/10.1186/s13048-019-0479-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334460PMC
January 2019
1 Read

The role of the endocannabinoid system in female reproductive tissues.

J Ovarian Res 2019 Jan 15;12(1). Epub 2019 Jan 15.

Department of Pediatrics, and the Graduate Program in Medical Sciences, McMaster University, 1280 Main Street West, HSC 3N11H, Hamilton, ON, L8S 4K1, Canada.

There has been increasing interest in the role of endocannabinoids as critical modulators of the female reproductive processes. Endocannabinoids are natural ligands of cannabinoid, vanilloid, and peroxisome proliferator-activated receptors. Together with their receptors, enzymes and downstream signaling targets, they form the endocannabinoid system (ECS). Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0478-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332911PMC
January 2019
27 Reads

Recurrent ovarian mixed germ cell tumor with unusual malignant transformation: a case report.

J Ovarian Res 2019 Jan 10;12(1). Epub 2019 Jan 10.

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, 201, Section 2, Shih-Pai Road, Taipei, 112, Taiwan, Republic of China.

Background: The value of this report is the identification of late recurrence with an extremely unusual combination of malignant transformation. In particular, the retroconversion of immature to mature teratoma as well as a somatic-type malignant transformation were both observed postchemotherapeutically in our case.

Case Presentation: We report the case of a 20-year-old girl who completed fertility-sparing surgery and chemotherapy under the diagnosis of ovarian mixed germ cell tumor (immature teratoma and yolk sac tumor) and experienced subsequent recurrence 4 years after a second debulking surgery with a somatic type malignant transformation (teratoma with melanoma and leiomyosarcoma). Read More

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http://dx.doi.org/10.1186/s13048-018-0476-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327407PMC
January 2019
13 Reads

Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets.

J Ovarian Res 2019 Jan 4;12(1). Epub 2019 Jan 4.

The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.

Ovarian cancer remains the most fatal gynecologic malignancy worldwide due to delayed diagnosis as well as recurrence and drug resistance. Thus, the development of new tumor-related molecules with high sensitivity and specificity to replace or supplement existing tools is urgently needed. Cancer-testis antigens (CTAs) are exclusively expressed in normal testis tissues but abundantly found in several types of cancers, including ovarian cancer. Read More

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http://dx.doi.org/10.1186/s13048-018-0475-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318940PMC
January 2019
18 Reads

Diversity of imaging features of ovarian sclerosing stromal tumors on MRI and PET-CT: a case report and literature review.

J Ovarian Res 2018 Dec 20;11(1):101. Epub 2018 Dec 20.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Background: Sclerosing stromal tumors (SST) are rare, benign tumors classified as sex cord stromal tumors. To our knowledge, positron emission tomography with computed tomography (PET-CT) findings of SST have only been described in one report and imaging findings on diffusion-weighted imaging (DWI) have only been described in three reports. Characteristic imaging features of SST on PET-CT and DWI have not yet been identified. Read More

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http://dx.doi.org/10.1186/s13048-018-0473-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302382PMC
December 2018
3 Reads

Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature.

J Ovarian Res 2018 Dec 14;11(1):100. Epub 2018 Dec 14.

Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.

Background: Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal girls and in women younger than 30 years. Although JGCT have different histologic features compared to AGCT, the two types have similar imaging features because they have similar gross appearance. Read More

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http://dx.doi.org/10.1186/s13048-018-0474-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293549PMC
December 2018
3 Reads

Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats.

J Ovarian Res 2018 Nov 26;11(1):99. Epub 2018 Nov 26.

Department of Anatomy, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Ficus deltoidea is one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community to treat various ailments and for maintenance of female reproductive health. The objective of this study is to evaluate the potential protective roles of Ficus deltoidea against BPA-induced toxicity of the pituitary-ovarian axis in pre-pubertal female rats. In this study, four groups of pre-pubertal female Sprague Dawley rats were administered with the followings by oral gavage for a period of six weeks: NC (negative control- treated with vehicle), PC (positive control-treated with BPA at 10 mg/kg/BW), F (treated with Ficus deltoidea at 100 mg/kg/BW, then exposed to BPA at 10 mg/kg/BW) and FC (Ficus deltoidea control - treated with Ficus deltoidea at 100 mg/kg/BW). Read More

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http://dx.doi.org/10.1186/s13048-018-0466-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260867PMC
November 2018
3 Reads
2.428 Impact Factor

Expression of Concern to: Does ovary need D-chiro-inositol?

J Ovarian Res 2018 11 23;11(1):98. Epub 2018 Nov 23.

Obstetrics and Gynecology Department, G. Martino Hospital, Messina, Italy.

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http://dx.doi.org/10.1186/s13048-018-0470-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260655PMC
November 2018
1 Read

Isolated ovarian tuberculosis in an Immuno- competent woman in the post partum period: case report.

Authors:
Wondimu Gudu

J Ovarian Res 2018 Nov 22;11(1):97. Epub 2018 Nov 22.

Department of Obstetrics & Gynecology, Saint Paul's Hospital Millennium Medical College, P.O.Box 1271, Addis Ababa, Ethiopia.

Background: Pelvic tuberculosis is a rare form of extrapulmonary tuberculosis. It commonly involves the fallopian tubes and the uterus from a lympho-hematogeneous spread. The presentation of pelvic tuberculosis as an isolated ovarian abscess is extremely rare and is reported only twice. Read More

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http://dx.doi.org/10.1186/s13048-018-0472-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249878PMC
November 2018
15 Reads

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women.

J Ovarian Res 2018 Nov 21;11(1):95. Epub 2018 Nov 21.

Department of Obstetrics and Gynecology, The Hebrew University Hadassah Medical Center, Jerusalem, Israel.

Background: It has been shown - mostly in animal models - that circadian clock genes are expressed in granulosa cells and in corpora luteum and might be essential for the ovulatory process and steroidogenesis.

Objective: We sought to investigate which circadian clock genes exist in human granulosa cells and whether their expression and activity decrease during aging of the ovary.

Study Design: Human luteinized granulosa cells were isolated from young (age 18-33) and older (age 39-45) patients who underwent in-vitro fertilization treatment. Read More

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http://dx.doi.org/10.1186/s13048-018-0471-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247686PMC
November 2018
1 Read

Decrease in preovulatory serum estradiol is a valuable marker for predicting premature ovulation in natural/unstimulated in vitro fertilization cycle.

J Ovarian Res 2018 Nov 21;11(1):96. Epub 2018 Nov 21.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.

Background: Premature ovulation occurs at a high rate in natural-cycle in vitro fertilization (IVF), and cycle cancellation further hampers the overall efficiency of the procedure. While lower levels of estradiol (E2) are observed in preovulatory follicles, it is unclear whether declines in E2 can be used as an effective marker of premature ovulation.

Methods: This retrospective analysis includes 801 natural/unstimulated IVF/ICSI cycles undergoing scheduled ovum pick-up (OPU) and 153 natural/unstimulated IVF/ICSI cycles undergoing emergency OPU at a university IVF center from May 2014 to February 2017. Read More

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http://dx.doi.org/10.1186/s13048-018-0469-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247609PMC
November 2018
14 Reads

Luteolin sensitizes the antitumor effect of cisplatin in drug-resistant ovarian cancer via induction of apoptosis and inhibition of cell migration and invasion.

J Ovarian Res 2018 Nov 19;11(1):93. Epub 2018 Nov 19.

Department of Obstetrics and Gynecology, Jinshan branch of Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.

Luteolin, a polyphenolic flavone, has been demonstrated to exert anti-tumor activity in various cancer types. Cisplatin drug resistance is a major obstacle in the management of ovarian cancer. In the present study, we investigated the chemo-sensitizing effect of luteolin in both cisplatin-resistant ovarian cancer cell line and a mice xenotransplant model. Read More

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http://dx.doi.org/10.1186/s13048-018-0468-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241043PMC
November 2018
2 Reads

Identification of core genes in ovarian cancer by an integrative meta-analysis.

J Ovarian Res 2018 Nov 19;11(1):94. Epub 2018 Nov 19.

The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330031, People's Republic of China.

Background: Epithelial ovarian cancer is one of the most severe public health threats in women. Since it is still challenging to screen in early stages, identification of core genes that play an essential role in epithelial ovarian cancer initiation and progression is of vital importance.

Results: Seven gene expression datasets (GSE6008, GSE18520, GSE26712, GSE27651, GSE29450, GSE36668, and GSE52037) containing 396 ovarian cancer samples and 54 healthy control samples were analyzed to identify the significant differentially expressed genes (DEGs). Read More

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http://dx.doi.org/10.1186/s13048-018-0467-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240943PMC
November 2018
24 Reads

Diagnostic value of the gynecology imaging reporting and data system (GI-RADS) with the ovarian malignancy marker CA-125 in preoperative adnexal tumor assessment.

J Ovarian Res 2018 Nov 3;11(1):92. Epub 2018 Nov 3.

Clinical Unit of Obstetrics, Women's Disease and Gynecological Oncology, sw. Jozefa 53/59, United District Hospital, Collegium Medicum University of Nicolaus Copernicus in Toruń, Torun, Poland.

Objectives: The purpose of this study is to assess the preoperative evaluation of an adnexal mass using the GI-RADS classification and to verify whether CA-125 measurement can offer any additional benefits to the GI-RADS-based prediction of ovarian tumor malignancy.

Material And Methods: In this study, we assessed a total of 215 women with an adnexal tumor using the GI-RADS classification combined with CA-125 measurement. All adnexal masses underwent histological verification. Read More

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http://dx.doi.org/10.1186/s13048-018-0465-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215357PMC
November 2018
20 Reads

Comparison of stage III mucinous and serous ovarian cancer: a case-control study.

J Ovarian Res 2018 Oct 30;11(1):91. Epub 2018 Oct 30.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, BaskentUniversity, Ankara, Turkey.

Background: The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplatin chemotherapy to those of women with stage III serous epithelial ovarian cancer (EOC) treated in the similar manner.

Methods: We performed a multicenter, retrospective review to identify patients with stage III MOC at seven gynecologic oncology departments in Turkey. Eighty-one women with MOC were included. Read More

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http://dx.doi.org/10.1186/s13048-018-0464-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208168PMC
October 2018
13 Reads

DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway.

J Ovarian Res 2018 Oct 18;11(1):90. Epub 2018 Oct 18.

College of Medicine, Jiaxing University, Jiaxing, 314001, China.

Background: The death-domain-associated protein (DAXX) was originally identified as a protein that binds to the transmembrane death receptor FAS and enhances both FAS-induced and transforming growth factor-β-dependent apoptosis. In a previous study, we found that nude mice injected with DAXX-overexpressing cells (ES-2-DAXX) accumulated large concentrations of first-generation ascites cells (I ascites cells). The role of DAXX in the development of ascites is unknown. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-018-0462-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193355PMC
October 2018
14 Reads

Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5.

J Ovarian Res 2018 Oct 16;11(1):89. Epub 2018 Oct 16.

Laboratory for Aging and Infertility Research, Northeastern University, Boston, MA, 02115, USA.

Background: Cellular metabolic changes that accompany malignant transformation have been heralded as hallmark features of cancer. However, metabolic signatures between neoplasms can be unique, allowing for distinctions in malignancy, invasion and chemoresistance between cancer types and subtypes. Mitochondria are central metabolic mediators, as cellular bioenergetics veers from oxidative phosphorylation to glycolysis. Read More

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http://dx.doi.org/10.1186/s13048-018-0463-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192357PMC
October 2018
3 Reads

Mass spectrometry-based proteomics techniques and their application in ovarian cancer research.

J Ovarian Res 2018 Oct 1;11(1):88. Epub 2018 Oct 1.

Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780, Poznań, Poland.

Ovarian cancer has emerged as one of the leading cause of gynecological malignancies. So far, the measurement of CA125 and HE4 concentrations in blood and transvaginal ultrasound examination are essential ovarian cancer diagnostic methods. However, their sensitivity and specificity are still not sufficient to detect disease at the early stage. Read More

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http://dx.doi.org/10.1186/s13048-018-0460-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166298PMC
October 2018
1 Read

CT of ovarian cancer: 3D cinematic rendering for preoperative evaluation.

J Ovarian Res 2018 Sep 26;11(1):86. Epub 2018 Sep 26.

Radiology Department, Yunnan Cancer Hospital/The Third Affiliated Hospital of Kunming Medical University, 519# Kunzhou Street, Kunming, 650118, Yunnan, China.

Background: Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgical resectability. As a new three-dimensional postprocessing tool for CT images, cinematic rendering (CR) has the potential to depict anatomic details accurately. Read More

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http://dx.doi.org/10.1186/s13048-018-0461-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158831PMC
September 2018
15 Reads

Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence.

J Ovarian Res 2018 Sep 26;11(1):87. Epub 2018 Sep 26.

Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.

Background: Fibroblast growth factor 13 (FGF13) is one of the most highly expressed FGF family members in adult mouse ovary. However, its precise roles in ovarian function remain largely unknown. We sought to evaluate the associations between FGF13 in follicular fluid and oocyte developmental competence in patients with polycystic ovary syndrome (PCOS). Read More

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http://dx.doi.org/10.1186/s13048-018-0455-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158872PMC
September 2018
15 Reads