27,693,491 results match your criteria Journal of Otolaryngology: Head and Neck Surgery [Journal]

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Detecting Early Pancreatic Cancer: Current Problems and Future Prospects.

Gut Liver 2019 Apr 23. Epub 2019 Apr 23.

Divisions of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18491DOI Listing
April 2019
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Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam.

Gut Liver 2019 Apr 23. Epub 2019 Apr 23.

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Oita, Japan.

Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. Read More

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http://dx.doi.org/10.5009/gnl18137DOI Listing
April 2019
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Factors Influencing Motor Outcome of Hippotherapy in Children with Cerebral Palsy.

Neuropediatrics 2019 Apr 22. Epub 2019 Apr 22.

Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective:  This study was aimed to identify individual factors influencing the gross motor outcome of hippotherapy in children with cerebral palsy (CP).

Methods:  One hundred and forty-six children with CP (mean age: 5.78 ± 1. Read More

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http://dx.doi.org/10.1055/s-0039-1685526DOI Listing

A Hemimotor Deficit in an 18-Month-Old Boy Revealing Acute Myelitis.

Neuropediatrics 2019 Apr 22. Epub 2019 Apr 22.

CHRU de Brest, service de pédiatrie, Brest, France.

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http://dx.doi.org/10.1055/s-0039-1684051DOI Listing

Effects of systematic bisphosphonate use in patients under orthodontic treatment: a systematic review.

Eur J Orthod 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthodontics, School of Health Sciences, Faculty of Dentistry, Aristotle University of Thessaloniki, Greece.

Background: Bisphosphonates are a class of drugs prescribed for several osseous related disorders owing to their ability to regulate bone turnover, which could in turn affect orthodontic treatment outcomes.

Objective: To examine the effect of bisphosphonate (BP) use on orthodontic patients through clinical and radiographic measurements.

Search Methods: Systematic and unrestricted search of 17 databases complemented with additional hand-searches were performed up to March 2019. Read More

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http://dx.doi.org/10.1093/ejo/cjz021DOI Listing

Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA.

DNA methylation acts at the interface of genetic and environmental factors relevant for autism spectrum disorder (ASD). Placenta, normally discarded at birth, is a potentially rich source of DNA methylation patterns predictive of ASD in the child. Here, we performed whole methylome analyses of placentas from a prospective study MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) of high-risk pregnancies. Read More

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http://dx.doi.org/10.1093/hmg/ddz084DOI Listing

Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar Dynein function in primary cilia.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

St. Vincent's Institute of Medical Research.

Mutations in subunits of the cilia-specific cytoplasmic Dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs), characterized by impaired bone growth and life-threatening perinatal respiratory complications. Different SRTD mutations result in varying disease severities. It remains unresolved whether this reflects the extent of retained hypomorphic protein functions or relative importance of the affected subunits for the activity of the CD2 holoenzyme. Read More

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http://dx.doi.org/10.1093/hmg/ddz083DOI Listing

A study of the mechanical properties of as-received and intraorally exposed single-crystal and polycrystalline orthodontic ceramic brackets.

Eur J Orthod 2019 Apr 23. Epub 2019 Apr 23.

Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Switzerland.

Background: Although ceramic brackets have been extensively used for decades in orthodontics there is not till today any study focusing on the possible deterioration of mechanical properties after in vivo ageing.

Objectives: To determine whether the mechanical properties of alumina orthodontic brackets change after intraoral ageing thereby assessing the validity of a theoretical model established for the performance of ceramics in wet environments.

Materials And Methods: Two alumina brackets, one single crystal (Radiance, American Orthodontics, Sheboygan, WI) and one polycrystalline (Clarity, 3M, St. Read More

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http://dx.doi.org/10.1093/ejo/cjz024DOI Listing

Basophil involvement in lupus nephritis: a basis for innovation in daily care.

Nephrol Dial Transplant 2018 Jul 25. Epub 2018 Jul 25.

Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252, Université Paris Diderot, Sorbonne Paris Cité, Faculté de Médecine site Bichat, Laboratoire d'Excellence Inflamex, DHU FIRE, Paris, France.

Lupus nephritis (LN) affects a large proportion of patients with systemic lupus erythematosus (SLE). LN can lead to end-stage renal disease depending on when it is diagnosed and on the adequacy of the treatment administered to the patient based on the class of LN. Determination of the class and activity of LN is only possible by histological analysis of kidney biopsies. Read More

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http://dx.doi.org/10.1093/ndt/gfy245DOI Listing

Targeted Knock-In Mice with a Human Mutation in GRTH/DDX25 Reveals the Essential Role of Phosphorylated GRTH in Spermatid Development during Spermatogenesis.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Section on Molecular Endocrinology, Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a testis specific member of the DEAD-box family of RNA helicases expressed in meiotic and haploid germ cells which plays an essential role in spermatogenesis. There are two species of GRTH the 56 kDa non-phospho and 61 kDa phospho forms. Our early studies revealed a missense mutation (R242H) of GRTH in azoospermic men that when expressed in COS1-cells lack the phospho-form of GRTH. Read More

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddz079DOI Listing
April 2019
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Long-Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture Prevention: A Systematic Review.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of Minnesota and Minneapolis VA Health Care System, Minneapolis, Minnesota (H.A.F., R.M., K.E.E., K.U., B.C.T., T.J.W.).

Background: Optimal long-term osteoporosis drug treatment (ODT) is uncertain.

Purpose: To summarize the effects of long-term ODT and ODT discontinuation and holidays.

Data Sources: Electronic bibliographic databases (January 1995 to October 2018) and systematic review bibliographies. Read More

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http://dx.doi.org/10.7326/M19-0533DOI Listing

Visual shape perception in the case of transparent objects.

J Vis 2019 Apr;19(4):24

Institut für Psychologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.

In order to estimate the shape of objects, the visual system must refer to shape-related regularities in the (retinal) image. For opaque objects, many such regularities have already been identified, but most of them cannot simply be transferred to transparent objects, because they are not available there at all or are available only in a substantially modified form. We here consider three potentially relevant regularities specific to transparent objects: optical background distortions due to refraction, changes in chromaticity and brightness due to absorption, and multiple mirror images due to specular reflection. Read More

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http://dx.doi.org/10.1167/19.4.24DOI Listing

From individual features to full faces: Combining aspects of face information.

J Vis 2019 Apr;19(4):23

Department of Vision Sciences, Glasgow Caledonian University, Glasgow, UK.

We investigated how information from face features is combined by comparing sensitivity to individual features with that for external (head shape, hairline) and internal (nose, mouth, eyes, eyebrows) feature compounds. Discrimination thresholds were measured for synthetic faces under the following conditions: (a) full-faces; (b) individual features (e.g. Read More

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http://jov.arvojournals.org/article.aspx?doi=10.1167/19.4.23
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http://dx.doi.org/10.1167/19.4.23DOI Listing
April 2019
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Postnatal Development of Mice with Combined Genetic Depletions of Lamin A/C, Emerin and Lamina-associated Polypeptide 1.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine.

Mutations in LMNA encoding lamin A/C and EMD encoding emerin cause cardiomyopathy and muscular dystrophy. Lmna null mice develop these disorders and have a lifespan of 7-8 weeks. Emd null mice show no overt pathology and have normal skeletal muscle but with regeneration defects. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/hmg/ddz082DOI Listing
April 2019
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National Institutes of Health Pathways to Prevention Workshop: Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of South Carolina, Arnold School of Public Health, Columbia, South Carolina (M.L.).

On 30 and 31 October 2018, the National Institutes of Health convened the Pathways to Prevention (P2P) Workshop: Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention to assess the available evidence on long-term (>3 years) use of drug therapies to prevent osteoporotic fractures and identify research gaps and needs for advancing the field. The workshop was cosponsored by the NIH Office of Disease Prevention (ODP), National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging. A multidisciplinary working group developed the agenda, and an Evidence-based Practice Center prepared an evidence report through a contract with the Agency for Healthcare Research and Quality to facilitate the discussion. Read More

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http://dx.doi.org/10.7326/M19-0961DOI Listing

Raising the Bar for Procedural Competency Among Hospitalists.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts (J.T.C., C.P.H., A.V., D.N.R., G.C.H.).

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http://dx.doi.org/10.7326/M18-3007DOI Listing

Maternal Glycemic Control in Type 1 Diabetes and the Risk for Preterm Birth: A Population-Based Cohort Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Karolinska Institutet, Stockholm, Sweden, and Statens Serum Institut, Copenhagen, Denmark (B.P.).

Background: Maternal type 1 diabetes (T1D) has been linked to preterm birth and other adverse pregnancy outcomes. How these risks vary with glycated hemoglobin (or hemoglobin A1c [HbA1c]) levels is unclear.

Objective: To examine preterm birth risk according to periconceptional HbA1c levels in women with T1D. Read More

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http://dx.doi.org/10.7326/M18-1974DOI Listing

Advising Patients on How to Achieve Long-Term Weight Loss.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Baltimore VA Medical Center Geriatric Research Education and Clinical Center and University of Maryland School of Medicine, Baltimore, Maryland (L.I.K., J.D.S.).

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http://dx.doi.org/10.7326/M19-0782DOI Listing

Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana (J.W.A., K.M.G.).

Background: Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management.

Objective: To identify some predictors of LTWL.

Design: The DPP (Diabetes Prevention Program) was a randomized controlled trial that compared weight loss with metformin, intensive lifestyle intervention (ILS), or placebo. Read More

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http://dx.doi.org/10.7326/M18-1605DOI Listing

Long-Term Weight Loss With Metformin or Lifestyle Intervention.

Authors:

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

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http://dx.doi.org/10.7326/P19-0006DOI Listing

Can We Pave the Pathway to Fracture Prevention?

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California (C.J.C.).

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http://dx.doi.org/10.7326/M19-1112DOI Listing

Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition.

Neuropsychopharmacology 2019 Apr 22. Epub 2019 Apr 22.

Department of Pharmaceutical Biosciences, Medical Mass Spectrometry Imaging, National Resource for Mass Spectrometry Imaging, Science for Life Laboratory, Uppsala University, Box 591, Uppsala, SE, 75124, Sweden.

The neurotransmitter of the cholinergic system, acetylcholine plays a major role in the brain's cognitive function and is involved in neurodegenerative disorders. Here, we present age-related alterations of acetylcholine levels after administration of the acetylcholinesterase inhibitor drug tacrine in normal mice. Using a quantitative, robust and molecular-specific mass spectrometry imaging method we found that tacrine administration significantly raised acetylcholine levels in most areas of sectioned mice brains, inter alia the striatum, hippocampus and cortical areas. Read More

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http://dx.doi.org/10.1038/s41386-019-0397-5DOI Listing

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Aging (Albany NY) 2019 Apr;11(7):2045-2070

See ACKNOWLEDGMENTS AND FUNDING.

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. Read More

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http://dx.doi.org/10.18632/aging.101900DOI Listing

Atomistic molecular dynamics simulations of the LCST conformational transition in poly(N-vinylcaprolactam) in water.

J Mol Graph Model 2019 Apr 12;90:51-58. Epub 2019 Apr 12.

School of Chemistry, V.N. Karazin Kharkiv National University, 4 Svobody Square, Kharkiv, 61022, Ukraine. Electronic address:

Thermoresponsive poly(N-vinylcaprolactam) (PVCL) has received growing interest due to a temperature-induced phase transition, which switches its solubility in aqueous solutions. However, the lower critical solution temperature (LCST) of PVCL is greatly influenced by the molecular weight, morphology and the environment. Therefore, despite of numerous experimental studies of the thermal response of PVCL, a driving force and a molecular origin of conformation transitions in solution remain far less studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10933263193010
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http://dx.doi.org/10.1016/j.jmgm.2019.04.004DOI Listing
April 2019
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Association between child marriage and utilization of maternal health care services in India: Evidence from a nationally representative cross-sectional survey.

Midwifery 2019 Apr 18;75:66-71. Epub 2019 Apr 18.

Department of Geography, University of Gour Banga, Malda 732103, West Bengal, India.

Objective: In an effort to improve utilization of maternal health care services, age at marriage of girls has gain very little attention by the policy maker and programmer. Studies have indicated that child marriage has serious negative consequences on maternal health. Moreover, there is a paucity of research on explaining the links between child marriage and maternal health care utilization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02666138193009
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http://dx.doi.org/10.1016/j.midw.2019.04.007DOI Listing
April 2019
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C9orf72 repeat expansions in South Africans with amyotrophic lateral sclerosis.

J Neurol Sci 2019 Apr 17;401:51-54. Epub 2019 Apr 17.

Neurology research group, Department of Medicine, University of Cape Town, Cape Town, South Africa; Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

The hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic variant found in individuals with sporadic amyotrophic lateral sclerosis (ALS), occurring at a frequency of between 7 and 11% in cohorts of European ancestry. While limited data suggest that C9-expansions (>30 repeats) are less frequent in African-Americans with ALS, there is no data on the frequency of C9-expansions among ALS subjects residing in Africa. We therefore investigated the frequency of this expansion mutation (using repeat-primed PCR) in a cohort of 143 South Africans (SA) with ALS. Read More

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http://dx.doi.org/10.1016/j.jns.2019.04.026DOI Listing

Induction of apoptosis in CD4(+) T-cells is linked with optimal treatment response in patients with relapsing-remitting multiple sclerosis treated with Glatiramer acetate.

J Neurol Sci 2019 Mar 29;401:43-50. Epub 2019 Mar 29.

Multiple Sclerosis Center, B' Neurological University Department, AHEPA General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address:

Background: Induction of T-cell apoptosis constitutes a mechanism of action for Glatiramer Acetate (GA). We investigated whether activation of apoptotic T-cell death may be indicative of optimal treatment response in patients with relapsing-remitting Multiple Sclerosis (RRMS), with respect to radiological activity.

Methods: We studied apoptotic markers on blood T-cells of forty patients with RRMS, 19 patients under GA and 21 patients under interferon-β (IFNβ), by flow cytometry. Read More

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http://dx.doi.org/10.1016/j.jns.2019.03.030DOI Listing

Characterizing the clinical implementation of a novel activation-repolarization metric to identify targets for catheter ablation of ventricular tachycardias using computational models.

Comput Biol Med 2019 Mar 23;108:263-275. Epub 2019 Mar 23.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom. Electronic address: https://kclpure.kcl.ac.uk/portal/martin.bishop.html.

Identification of targets for catheter ablation of ventricular tachycardias (VTs) remains a significant challenge. VTs are often driven by re-entrant circuits resulting from a complex interaction between the front (activation) and tail (repolarization) of the electrical wavefront. Most mapping techniques do not take into account the tissue repolarization which may hinder the detection of ablation targets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193009
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.018DOI Listing
March 2019
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Effects of di-n-butyl phthalate on photosynthetic performance and oxidative damage in different growth stages of wheat in cinnamon soils.

Environ Pollut 2019 Apr 11;250:357-365. Epub 2019 Apr 11.

Agro-Environmental Protection Institute, Ministry of Agriculture of China, Tianjin, 300191, China. Electronic address:

Herein, we investigated the effects of di-n-butyl phthalate (DBP) on photosynthesis, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) content, oxidative damage, and biomass accumulation of different tissues in wheat (Triticum aestivum L) planted in cinnamon soils. The photosynthetic or fluorescence parameters (except for the intercellular carbon dioxide concentration), chlorophyll content, RuBisCO content, and biomass of roots, stems, and leaves decreased at the seedling, jointing, and booting stages under the stress of DBP. Compared with the control, the content of superoxide anions and hydrogen peroxide in the roots, stems, and leaves increased with increasing DBP concentrations at the seedling, jointing, and booting stages. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.022DOI Listing

Patch-based lung ventilation estimation using multi-layer supervoxels.

Comput Med Imaging Graph 2019 Apr 5;74:49-60. Epub 2019 Apr 5.

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, UK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, UK.

Patch-based approaches have received substantial attention over the recent years in medical imaging. One of their potential applications may be to provide more anatomically consistent ventilation maps estimated on dynamic lung CT. An assessment of regional lung function may act as a guide for radiotherapy, ensuring a more accurate treatment plan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08956111183018
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http://dx.doi.org/10.1016/j.compmedimag.2019.04.002DOI Listing
April 2019
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Carbon black-induced detrimental effect on osteoblasts at low concentrations: Remarkably compromised differentiation without significant cytotoxicity.

Ecotoxicol Environ Saf 2019 Apr 19;178:211-220. Epub 2019 Apr 19.

Beijing Jishuitan Hospital, Peking University Health Science Center, Beijing, 100035, PR China. Electronic address:

Due to similar aerodynamic and micro-nano sized properties between airborne particles and synthetic nanoparticles, a large number of studies have been conducted using carbon-based particles, such as carbon black (CB), carbon nanotubes and graphite, in order to achieve deeper understandings of their adverse effects on human health. It has been reported that particulate matters can aggravate morbidity of patients suffering from bone and joint diseases, e.g. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.029DOI Listing

Ecophysiological response of Lippia gracilis (Verbanaceae) to duration of salt stress.

Ecotoxicol Environ Saf 2019 Apr 19;178:202-210. Epub 2019 Apr 19.

Programa de Pós-graduação em Ciências Naturais (PPGCN), Universidade do Estado do Rio Grande do Norte (UERN), Rua Professor Antônio Campos, s/n, CEP: 59600-000, Mossoró-RN, Brazil; Departamento de Ciências Biológicas, Faculdade de Ciências Exatas e Naturais (FANAT), Universidade do Estado do Rio Grande do Norte (UERN), Brazil. Electronic address:

The objective of this work was to investigate the effects of salinized water on Lippia gracilis by determining the ion accumulation capacity and morphophysiological changes as a function of salinity and time of exposure to stress. L. gracilis was irrigated with water containing different concentrations of salts and electrical conductivities. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.016DOI Listing

Patterns of bacterial and archaeal communities in sediments in response to dam construction and sewage discharge in Lhasa River.

Ecotoxicol Environ Saf 2019 Apr 19;178:195-201. Epub 2019 Apr 19.

Department of Water Resources and Hydropower Engineering, Wuhan University, Wuhan, 430000, China. Electronic address:

The increased anthropogenic activities in the Tibetan Plateau may threaten the river environmental safety. However, limited information is available on the Lhasa River in the Tibetan Plateau, which is known as the remaining pure land on Earth. Here, we firstly investigated the distribution patterns of bacterial and archaeal communities in sediments in response to dam construction and sewage discharge along the reaches of the Lhasa River. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.03.107DOI Listing

Simultaneous determination of polycyclic aromatic hydrocarbons and their chlorinated derivatives in grilled foods.

Ecotoxicol Environ Saf 2019 Apr 19;178:188-194. Epub 2019 Apr 19.

Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) are unintentionally generated in foods that are cooked, and dietary ingestion of these PAHs is regarded as the dominant route of exposure to PAHs. Some chlorinated PAHs (ClPAHs) are more toxic than their corresponding parent PAHs and can also be generated in food during cooking. Knowledge of the concentrations of ClPAHs in cooked foods has been limited by the lack of an adequate analytical method for measuring ClPAH concentrations in cooked foods. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.046DOI Listing

Does microhabitat influence the testate amoebae communities in the Nameri National Park, northeastern India? A tropical forest perspective.

Eur J Protistol 2019 Mar 28;69:88-101. Epub 2019 Mar 28.

Zoological Survey of India, Kolkata, West Bengal, India.

The community structure of testate amoebae inhabiting different microhabitats (soil and tree-moss) within a tropical forest biome in Nameri National Park, northeastern India, was investigated. A total of 33 testate amoebae species belonging to 13 genera were identified. Species belonging to the class Lobosea constituted 73% of total testate amoebae density in the soil habitat, whereas the class Filosea constituted the most dominant forms (58%) in the moist tree-moss habitat. Read More

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http://dx.doi.org/10.1016/j.ejop.2019.03.002DOI Listing

Prevalence of Helicobacter pylori infection in Latin America and the Caribbean populations: A systematic review and meta-analysis.

Cancer Epidemiol 2019 Apr 19;60:141-148. Epub 2019 Apr 19.

Epidemiology and Statistics Group, Research Center, A.C Camargo Cancer Center, São Paulo, Brazil.

Objective: To describe the prevalence of Helicobacter pylori (H. pylori) infection in Latin Americaand the Caribbean (LAC), through systematic review and meta-analysis by age groups and gender.

Methods: Systematic review and meta-analysis of the population-based observational epidemiological studies carried out in LAC, focused on the prevalence of H. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18777821193002
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http://dx.doi.org/10.1016/j.canep.2019.04.003DOI Listing
April 2019
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Revisit rates following pediatric coblation tonsillectomy.

Int J Pediatr Otorhinolaryngol 2019 Apr 16;122:130-132. Epub 2019 Apr 16.

Emergency Department, Affiliated Renhe Hospital of China Three Gorges University, Yichang, Hubei, China.

Objective: To explore the rate of emergency department (ED) revisits and hospital readmissions following coblation tonsillectomy in children with sleep-disordered breathing (SDB) and/or recurrent tonsillitis.

Methods: A total of 2045 children underwent coblation tonsillectomy were recruited in the retrospective study. The number of revisits or readmissions was recorded and the reasons were analyzed. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.04.013DOI Listing

The flux and impact of wastewater infrastructure microorganisms on human and ecosystem health.

Curr Opin Biotechnol 2019 Apr 19;57:145-150. Epub 2019 Apr 19.

School of Freshwater Sciences, University of Wisconsin-Milwaukee, 600 E. Greenfield Ave., Milwaukee, WI, 53204, USA.

Wastewater infrastructure is designed, in part, to remove microorganisms. However, many microorganisms are able to colonize infrastructure and resist treatment, resulting in an enormous flux of microorganisms to urban adjacent waters. These urban-associated microorganisms are discharged through three primary routes 1) failing infrastructure, 2) stormwater, and 3) treated wastewater effluent. Read More

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http://dx.doi.org/10.1016/j.copbio.2019.03.015DOI Listing

The influence of childhood obesity on spatio-temporal gait parameters.

Gait Posture 2019 Mar 30;71:69-73. Epub 2019 Mar 30.

Podiatry Department, Health Sciences Faculty, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Spain. Electronic address:

The musculoskeletal and neurosensorial development of children can be affected by excess body weight. Studies have examined how childhood obesity affects gait, but much about the influence of this factor remains to be determined. The aim of our study is to analyse, in a large sample of children, the influence of obesity on the spatiotemporal parameters of the gait cycle, in the most natural way possible, with the subjects walking overground at a self-selected speed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183191
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http://dx.doi.org/10.1016/j.gaitpost.2019.03.031DOI Listing
March 2019
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Exploring the Roles of Central and Peripheral Nervous System Function in Gait Stability: Preliminary Insights from Cancer Survivors.

Gait Posture 2019 Apr 6;71:62-68. Epub 2019 Apr 6.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA; School of Health & Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.

Background: Impairments in central and/or peripheral nervous systems are known to be associated with altered gait; however, the interplay between cognitive function, peripheral sensation, and orbital gait stability remains largely unclear. Elucidating these relationships is expected to provide a clearer understanding of potential fall risk factors across various populations and targets for novel interventions. Many patients diagnosed with cancer are treated with chemotherapy agents known to be neurotoxic to the central and/or peripheral nervous systems that can contribute to movement deficiencies, making this population a novel model to investigate these relationships. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183163
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.002DOI Listing
April 2019
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miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma.

Mol Ther Nucleic Acids 2019 Mar 13;16:391-406. Epub 2019 Mar 13.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli," 80138 Naples, Italy; IRGS, Biogem, Molecular and Precision Oncology Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy. Electronic address:

miR-125b, ubiquitously expressed and frequently dysregulated in several tumors, has gained special interest in the field of cancer research, displaying either oncogenic or oncosuppressor potential based on tumor type. We have previously demonstrated its tumor-suppressive role in multiple myeloma (MM), but the analysis of molecular mechanisms needs additional investigation. The purpose of this study was to explore the effects of miR-125b and its chemically modified analogs in modulating cell viability and cancer-associated molecular pathways, also focusing on the functional aspects of stress adaptation (autophagy and senescence), as well as programmed cell death (apoptosis). Read More

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http://dx.doi.org/10.1016/j.omtn.2019.02.023DOI Listing

The treatment gap for mental disorders and associated factors in the Czech Republic.

Eur Psychiatry 2019 Apr 19;59:37-43. Epub 2019 Apr 19.

National Institute of Mental Health, Klecany, Czech Republic; Third Faculty of Medicine, Charles University Prague, Czech Republic. Electronic address:

Objectives: To assess the extent of the treatment gap for mental disorders in the Czech Republic, determine factors associated with the utilization of mental health services and explore what influences willingness to seek mental health care.

Methods: Data from the CZEch Mental health Study, a nationally representative study of community-dwelling adults in the Czech Republic were used. The Mini International Neuropsychiatric Interview assessed the presence of mental disorders. Read More

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http://dx.doi.org/10.1016/j.eurpsy.2019.04.003DOI Listing

CIDR estrous synchronization in the Arabian Oryx (Oryx leucoryx).

Theriogenology 2019 Apr 15;132:113-117. Epub 2019 Apr 15.

Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

In Jordan, the Arabian Oryx (Oryx leucoryx) is considered among the most important wild ungulates. The Arabian Oryx is listed as vulnerable species according to the International Union for Conservation of Nature (IUCN). Based on author's knowledge, estrus synchronization in the Arabian Oryx has never been investigated. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.04.017DOI Listing
April 2019
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Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities.

Eur J Med Chem 2019 Apr 16;173:282-293. Epub 2019 Apr 16.

Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address:

Two series of andrographolide derivatives with introduction of amide moiety into ring A by Beckmann rearrangement were synthesized. In series 1, the ring A was converted to caprolactam, and an amide moiety was linked to C-19 of ring A in series 2. Among them, compound 8h exhibited obvious inhibition on HK2 enzyme activity (IC = 9. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.022DOI Listing
April 2019
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Antibacterial activity study of 1,2,4-triazole derivatives.

Eur J Med Chem 2019 Apr 16;173:274-281. Epub 2019 Apr 16.

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, PR China. Electronic address:

Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.043DOI Listing

Multitarget PPARγ agonists as innovative modulators of the metabolic syndrome.

Eur J Med Chem 2019 Apr 13;173:261-273. Epub 2019 Apr 13.

Department of Pharmacy, University of Chieti "G. d.Annunzio", Via Dei Vestini, 31, 66100, Chieti, Italy.

A multitarget pharmacologic approach could be advantageous for the therapy of metabolic multiple diseases, such as the metabolic syndrome, which is characterized by metabolic abnormalities associated with diabetes, obesity, hypertension, and increased cardiovascular risk. PPAR receptors play a critical role in metabolic disorders, affecting glucose and lipid metabolism. Drugs simultaneously targeting PPAR and other validated metabolic targets, represent a promising multitarget approach to combine antihyperglycemic, antihyperlipidemic, and antihypertensive effects. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.030DOI Listing

Synthesis and immunological studies of β-1,2-mannan-peptide conjugates as antifungal vaccines.

Eur J Med Chem 2019 Apr 5;173:250-260. Epub 2019 Apr 5.

Department of Chemistry, University of Florida, 214 Leigh Hall, Gainesville, FL, 32611, USA. Electronic address:

Fungal cell surface carbohydrates and proteins are useful antigens for the development of antifungal vaccines. In this study, glycopeptides consisting of the β-1,2-mannan and N-terminal peptide epitopes of Candida albicans (C. albicans) cell wall phosphomannan complex and Als1p (rAls1p-N) protein, respectively, were synthesized and covalently conjugated with keyhole limpet hemocyanin (KLH) and human serum albumin (HSA) through homobifunctional disuccinimidyl glutarate. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.001DOI Listing

Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors.

Eur J Med Chem 2019 Apr 9;173:240-249. Epub 2019 Apr 9.

Ankara University, Faculty of Pharmacy, Department of Pharmacology, 06100, Tandoğan-Ankara, Turkey.

In this study, a series of benzimidazoles bearing thiosemicarbazide chain or triazole and thiadiazole rings were designed and synthesized. Crystal and molecular structure of the compound 5c has been characterized by single crystal X-ray crystallographic analysis. EGFR kinase inhibitory potencies of synthesized compounds were compared with erlotinib in vitro and most of the compounds exhibited significant activities. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.012DOI Listing

Design, synthesis and biological evaluation of novel neuchromenin analogues as potential antifungal agents.

Eur J Med Chem 2019 Apr 14;173:228-239. Epub 2019 Apr 14.

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100, Shaanxi Province, China. Electronic address:

In continuation of our program to discover new potential antifungal agents, thirty-two neuchromenin analogues were synthesized and characterized by the spectroscopic analysis. By using the mycelium growth rate method, the target compounds were evaluated systematically for antifungal activities in vitro against six plant pathogenic fungi, and structure-activity relationships (SAR) were derived. Compounds 6b-c, and 6l showed obvious inhibition activity on each of the fungi at 50 μg/mL. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.029DOI Listing

Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.

Eur J Med Chem 2019 Apr 6;173:213-227. Epub 2019 Apr 6.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an, 710069, China. Electronic address:

TMCA (3,4,5-trimethoxycinnamic acid) ester and amide are privileged structural scaffolds in drug discovery which are widely distributed in natural products and consequently produced diverse therapeutically relevant pharmacological functions. Owing to the potential of TMCA ester and amide analogues as therapeutic agents, researches on chemical syntheses and modifications have been carried out to drug-like candidates with broad range of medicinal properties such as antitumor, antiviral, CNS (central nervous system) agents, antimicrobial, anti-inflammatory and hematologic agents for a long time. At the same time, SAR (structure-activity relationship) studies have draw greater attention among medicinal chemists, and many of the lead compounds were derived for various disease targets. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.009DOI Listing
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