2,015 results match your criteria Journal of Oncology [Journal]


Resection of Liver Metastases: A Treatment Provides a Long-Term Survival Benefit for Patients with Advanced Pancreatic Neuroendocrine Tumors: .

J Oncol 2018 14;2018:6273947. Epub 2018 Nov 14.

Pancreatic Surgery Department, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.

Purpose: Nonsurgical therapies, including biotherapy, chemotherapy, and liver-directed therapy, provided a limit survival benefit for PNET patients with hepatic metastases. With the development of liver resection technique, there was a controversy on whether to perform a liver resection for these patients.

Methods: A computerized search was made of the Medline/PubMed, EMbase, Cochrane Library, and SinoMed (CBM) before March 2018. Read More

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http://dx.doi.org/10.1155/2018/6273947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261248PMC
November 2018

Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.

J Oncol 2018 8;2018:6301980. Epub 2018 Nov 8.

Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil.

Introduction: Differential expression of genes encoding cytochrome P450 (CYP) and other oxygenases enzymes involved in biotransformation mechanisms of endogenous and exogenous compounds can lead to oral tumor development.

Objective: We aimed to identify the expression profile of these genes, searching for susceptibility biomarkers in oral squamous cell carcinoma.

Patients And Methods: Sixteen oral squamous cell carcinoma samples were included in this study (eight tumor and eight adjacent non-tumor tissues). Read More

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http://dx.doi.org/10.1155/2018/6301980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250001PMC
November 2018

PPAR Enhances Cancer Cell Chemotherapy Sensitivity by Autophagy Induction.

J Oncol 2018 4;2018:6458537. Epub 2018 Nov 4.

Department of Oncology, The Affiliated Wujin People's hospital, Jiangsu University, Changzhou, Jiangsu Province, China.

PPAR (peroxisome-proliferator-activated receptor ) plays a critical role in regulation of inflammation and cancer, while the regulatory mechanism of PPAR on cancer cell autophagy is still unclear. Here we found that PPAR enhanced autophagy in HEK293T, SW480, and Hela cell lines, which was independent of PPAR transcription activity. PPAR induced antiapoptotic Bcl2 protein degradation resulting in release of the Beclin-1/VPS34 complex. Read More

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http://dx.doi.org/10.1155/2018/6458537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241347PMC
November 2018

Small or Non-Small Cell Lung Cancer Based Therapy for Treatment of Large Cell Neuroendocrine Cancer of The Lung? University of Cincinnati Experience.

J Oncol 2018 1;2018:9761826. Epub 2018 Nov 1.

Department of Hematology-Oncology, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Ave, Cincinnati, OH 45267, USA.

Large cell neuroendocrine cancer (LCNEC) of the lung exhibits morphological and immunohistochemical characteristics of both neuroendocrine and large cell carcinomas. No defined optimal therapy has been described for this subset of patients and the question of whether these patients should be treated with non-small cell lung cancer (NSCLC) treatment protocols, according to the National Comprehensive Cancer Network (NCCN) guidelines, or with small cell lung cancer (SCLC) due to histological and clinical similarities is still uncertain. We conducted a retrospective review of patients identified with diagnosis of LCNEC of the lung at the University of Cincinnati Cancer Center from the year 2002 to 2012 to determine which treatment approach resulted in improved outcomes in this rare category of disease. Read More

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https://www.hindawi.com/journals/jo/2018/9761826/
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http://dx.doi.org/10.1155/2018/9761826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236557PMC
November 2018
1 Read

Risk Factors for Fatal Pulmonary Hemorrhage following Concurrent Chemoradiotherapy in Stage 3B/C Squamous-Cell Lung Carcinoma Patients.

J Oncol 2018 1;2018:4518935. Epub 2018 Nov 1.

Bahcesehir University Medical Faculty, Department of Radiation Oncology, Istanbul, Turkey.

We aimed to identify the fatal pulmonary hemorrhage- (FPH-) related risk factors in stage 3B/C squamous-cell lung carcinoma (SqCLC) patients treated with definitive concurrent chemoradiotherapy (C-CRT). Medical records of 505 stage 3B/C SqCLC patients who underwent 66 Gy radiotherapy plus 1-3 cycles of concurrent chemotherapy with available pretreatment thoracic computerized tomography scans were retrospectively analyzed. Primary end-point was the identification of FPH-related risk factors. Read More

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http://dx.doi.org/10.1155/2018/4518935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236701PMC
November 2018

Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy.

J Oncol 2018 25;2018:8653489. Epub 2018 Oct 25.

Division of Clinical Physiology and Therapeutics, Keio University, Faculty of Pharmacy, 1-5-30, Shiabakoen, Minato-Ku, Tokyo, Japan.

Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or adoptive T cell therapies, have contributed to better outcomes in cancer patients. However, there are still many cancers with no cure. Therefore, combinations of several treatment strategies are being explored, and enhancing anticancer immunity will play an important role to combat the disease. Read More

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http://dx.doi.org/10.1155/2018/8653489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222238PMC
October 2018

Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer.

J Oncol 2018 16;2018:3812581. Epub 2018 Oct 16.

Department of System Biology, Unit of Biochemistry and Molecular Biology, University of Alcalá, Alcalá de Henares, Spain.

We reported that insulin receptor substrate 4 (IRS-4) levels increased in tissue from colorectal cancer (CRC) patients and promoted retinoblastoma-cyclin-dependent kinase activation. The aim of the present study was to evaluate the effect of IRS-4 on IGF-1 receptor pathway and its impact on procaspase 3 and PARP expression in RKO and HepG2 cancer cell lines. The results obtained were compared with those obtained from biopsies of patients with CRC (n = 18), tubulovillous adenomas (TA) (n = 2) and in matched adjacent normal colorectal (MANC) tissue (n = 20). Read More

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https://www.hindawi.com/journals/jo/2018/3812581/
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http://dx.doi.org/10.1155/2018/3812581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206579PMC
October 2018
4 Reads

Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA.

J Oncol 2018 11;2018:2183179. Epub 2018 Oct 11.

Department of Emergency Medicine, Inha University School of Medicine, Incheon, Republic of Korea.

Background/aims: Febrile neutropenia is considered as one of the most important and potentially life-threatening oncologic emergencies, which requires prompt medical assessment and treatment with antibiotics. This was a single-center retrospective study that investigated the prognostic factors predicting poor outcome in patients with cancer who presented with febrile neutropenia at the emergency department (ED).

Methods: The medical records of patients diagnosed with febrile neutropenia in the ED from January 2014 to December 2017 were reviewed. Read More

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https://www.hindawi.com/journals/jo/2018/2183179/
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http://dx.doi.org/10.1155/2018/2183179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201329PMC
October 2018
5 Reads

Treatment-Related Adverse Effects in Lung Cancer Patients after Stereotactic Ablative Radiation Therapy.

J Oncol 2018 4;2018:6483626. Epub 2018 Oct 4.

Cancer Research Institute and School of Health Sciences, University of South Australia, Adelaide SA 5001, Australia.

Introduction: Lung cancer is a disease which, despite the advancements in treatment, still has a very poor 5-year survival rate. Stereotactic ablative radiation therapy (SABR) is a highly advanced, sophisticated, and safe treatment which allows patients with early stage lung cancer to be treated effectively without invasive procedures and with excellent clinical outcomes. Avoiding surgery minimises morbidity and recovery time, bettering patients' quality of life. Read More

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http://dx.doi.org/10.1155/2018/6483626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193322PMC
October 2018
1 Read

Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer.

J Oncol 2018 1;2018:3725837. Epub 2018 Oct 1.

Division of Radiation Oncology, Regional Cancer Centre, Trivandrum, India.

Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. Read More

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https://www.hindawi.com/journals/jo/2018/3725837/
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http://dx.doi.org/10.1155/2018/3725837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188855PMC
October 2018
3 Reads

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis.

J Oncol 2018 26;2018:3098940. Epub 2018 Sep 26.

Department of Dermatovenereology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia.

Background: BCC is currently the most common type of skin cancer in humans. Although having a low-grade malignancy and metastatic potential, BCC is locally aggressive and destructive. Despite numerous studies, the origin of BCC, whether arising from the follicular or interfollicular layer, remains controversial. Read More

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http://dx.doi.org/10.1155/2018/3098940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178174PMC
September 2018
1 Read

HBV-DNA Load-Related Peritumoral Inflammation and ALBI Scores Predict HBV Associated Hepatocellular Carcinoma Prognosis after Curative Resection.

J Oncol 2018 20;2018:9289421. Epub 2018 Sep 20.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Background: Both persistent inflammatory activity and liver function damage contribute to a poor prognosis of hepatocellular carcinoma (HCC). This study aimed to develop nomograms that incorporate hepatitis virus B (HBV)-related peritumoral inflammation score (PIS) and liver function based on ALBI score to predict postoperative outcomes of HCC.

Methods: The prognostic roles of HBV-related preoperative PIS and ALBI scores in HCC recurrence were examined, and then two nomograms were constructed. Read More

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http://dx.doi.org/10.1155/2018/9289421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171205PMC
September 2018

Additional Biomarkers beyond RAS That Impact the Efficacy of Cetuximab plus Chemotherapy in mCRC: A Retrospective Biomarker Analysis.

J Oncol 2018 16;2018:5072987. Epub 2018 Sep 16.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Purpose: We aimed to identify new predictive biomarkers for cetuximab in first-line treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC).

Methods: The study included patients with KRAS wild-type unresectable liver-limited mCRC treated with chemotherapy with or without cetuximab. Next-generation sequencing was done for single nucleotide polymorphism according to custom panel. Read More

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https://www.hindawi.com/journals/jo/2018/5072987/
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http://dx.doi.org/10.1155/2018/5072987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165607PMC
September 2018
2 Reads

Outcomes Following Salvage Radiation and Systemic Therapy for Isolated Locoregional Recurrence of Breast Cancer after Mastectomy: Impact of Constructed Biologic Subtype.

J Oncol 2018 12;2018:4736263. Epub 2018 Sep 12.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: This study examines factors associated with outcomes following salvage radiation and systemic therapy for breast cancer patients who developed isolated locoregional recurrence (ILRR) after mastectomy alone, while focusing on the prognostic significance of constructed biologic subtype in this setting.

Methods And Materials: 269 postmastectomy patients in total treated for ILRR were included. Cumulative incidence of locoregional control (LRC), distant metastasis (DM)-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were calculated using Kaplan-Meier method. Read More

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http://dx.doi.org/10.1155/2018/4736263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157175PMC
September 2018
1 Read

The Utility of Preoperative Vascular Grading in Patients Undergoing Surgery First for Pancreatic Cancer: Does Radiologic Arterial or Venous Involvement Predict Pathologic Margin Status?

J Oncol 2018 13;2018:7675262. Epub 2018 Aug 13.

Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

Controversy exists on accurately grading vascular involvement on preoperative imaging for pancreatic ductal adenocarcinoma. We reviewed the association between preoperative imaging and margin status in 137 patients. Radiologists graded venous involvement based on the Ishikawa classification system and arterial involvement based on preoperative imaging. Read More

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http://dx.doi.org/10.1155/2018/7675262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110012PMC

Correlation between Psychosocial Distress and Quality of Life in Patients with Nasopharyngeal Carcinoma following Radiotherapy.

J Oncol 2018 6;2018:3625302. Epub 2018 Aug 6.

Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei, Anhui 230601, China.

The aim of this study was to investigate the relationship between psychosocial distress and quality of life (QOL) in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Fifty-three patients with an initial diagnosis of NPC were enrolled in this study. The psychological Distress Thermometer (DT) and Functional Assessment of Cancer Therapy-Head & Neck (FACT-H&N) were conducted before and after radiotherapy in NPC patients. Read More

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http://dx.doi.org/10.1155/2018/3625302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106906PMC
August 2018
5 Reads

MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer.

J Oncol 2018 6;2018:5167829. Epub 2018 Aug 6.

Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.

MicroRNAs (miRNAs) are small, highly conserved noncoding RNAs molecules, consisting of 18-25 nucleotides that regulate gene expression by binding to complementary binding sites within the 3'untranslated region (3'UTR) of target mRNAs. MiRNAs have been involved in regulating gene expression and diverse physiological and pathological processes. Several studies have reported that miR-30a, situated on chromosome 6q. Read More

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http://dx.doi.org/10.1155/2018/5167829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106977PMC
August 2018
7 Reads

A Machine Learning Approach for the Association of ki-67 Scoring with Prognostic Factors.

Authors:
E Dirican E Kiliç

J Oncol 2018 7;2018:1912438. Epub 2018 Aug 7.

General Surgery, Faculty of Medicine, Mustafa Kemal University, Hatay 31000, Turkey.

ki-67 score is a solid tumor proliferation marker being associated with the prognosis of breast carcinoma and its response to neoadjuvant chemotherapy. In the present study, we aimed to investigate the way of clustering of prognostic factors by ki-67 score using a machine learning approach and multiple correspondence analysis. In this study, 223 patients with breast carcinoma were analyzed using the random forest method for classification of prognostic factors according to ki-67 groups (<14% and >14%). Read More

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https://www.hindawi.com/journals/jo/2018/1912438/
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http://dx.doi.org/10.1155/2018/1912438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106968PMC
August 2018
6 Reads

The Association of Simultaneous Increase in Interleukin-6, C Reactive Protein, and Matrix Metalloproteinase-9 Serum Levels with Increasing Stages of Colorectal Cancer.

J Oncol 2018 30;2018:2830503. Epub 2018 Jul 30.

Department of Pathology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Background: Tumor development and growth are driven in many cases by inflammatory cells, which can produce cytokines and other factors that can stimulate the development of the malignant process. The aim of this study was to evaluate interleukin-6 (IL-6), C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9), serum levels in patients with colorectal cancer (CRC), and their association with the stage of CRC.

Methods: IL-6, MMP-9, and CRP serum levels were measured in 75 patients with CRC just before surgical treatment, as well as in 20 healthy individuals as controls. Read More

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http://dx.doi.org/10.1155/2018/2830503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091449PMC

Clinical and Molecular Characteristics Associated with Survival in Advanced Melanoma Treated with Checkpoint Inhibitors.

J Oncol 2018 17;2018:6279871. Epub 2018 Jul 17.

Hurley Medical Center/Michigan State University, 1 Hurley Plaza, Flint, Michigan 48503, USA.

Background: We performed meta-analysis to gather more evidence regarding clinical-molecular subgroups associated with better overall survival (OS) in advanced melanoma treated with checkpoint inhibitors.

Materials And Methods: We performed a systematic search of PubMed, Scopus, Cochrane Library, and clinical trial.gov. Read More

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http://dx.doi.org/10.1155/2018/6279871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077519PMC

Inhibition of MDM2 via Nutlin-3A: A Potential Therapeutic Approach for Pleural Mesotheliomas with MDM2-Induced Inactivation of Wild-Type P53.

J Oncol 2018 17;2018:1986982. Epub 2018 Jul 17.

Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Previously, our group demonstrated that nuclear expression of E3 ubiquitin ligase (MDM2) in malignant pleural mesothelioma (MPM) is significantly associated with decreased overall survival. A possible explanation may be that overexpression of MDM2 leads to a proteasomal degradation of TP53 that eventually results in a loss of TP53-induced apoptosis and senescence. It is well known from other tumor entities that restoration of TP53 activity, e. Read More

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http://dx.doi.org/10.1155/2018/1986982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077509PMC
July 2018
8 Reads

S100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer.

J Oncol 2018 9;2018:1828791. Epub 2018 Jul 9.

Department of General Surgery, Gulhane Education and Research Hospital, Ankara, Turkey.

Background: Globally, the colorectal cancers rank the third in terms of cancer incidence and rank the fourth in cancer-associated deaths. S100A4, an important member of the S100 protein family, serves to promote tumor progression and metastasis. By conducting this study, we aim to examine the role of S100A4 in the prognosis of colon cancer and to demonstrate its prognostic significance. Read More

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http://dx.doi.org/10.1155/2018/1828791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077577PMC
July 2018
27 Reads

Research Priorities and Resource Allocation in the Investigation of New Drugs for Cancer in Least Developed Countries.

J Oncol 2018 2;2018:8092702. Epub 2018 Jul 2.

Faculty of Health Sciences, University of Brasilia (UnB), Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Brazil.

Cancer incidence has increased significantly in low- and middle-income countries. The priorities of international health research are not always aligned with the global burden of cancer. This study aims to analyze global tendencies in clinical trials in oncology and discuss research priorities and resource allocation in the investigation of new drugs for cancers that significantly affect the least developed countries. Read More

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http://dx.doi.org/10.1155/2018/8092702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051037PMC
July 2018
7 Reads

The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review.

J Oncol 2018 2;2018:1236787. Epub 2018 Jul 2.

Mental Health and Wellbeing Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Jette, Brussels, Belgium.

This article reviews the role of the vagus nerve in tumor modulation and cancer prognosis. We present a systematic review of 12 epidemiological studies examining the relationship between heart rate variability, the main vagus nerve index, and prognosis in cancer patients (survival and tumor markers). These studies show that initially high vagal nerve activity predicts better cancer prognosis, and, in some studies, independent of confounders such as cancer stage and treatments. Read More

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http://dx.doi.org/10.1155/2018/1236787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051067PMC
July 2018
15 Reads

Survival Outcomes and Factors Associated with Revision Surgery for Metastatic Disease of the Spine.

J Oncol 2018 25;2018:6140381. Epub 2018 Jun 25.

Department of Orthopaedic Surgery, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.

Study Design: Retrospective review of a prospective database.

Objective: Certain subset of patients undergoing surgical treatment for spinal metastasis will require a revision surgery in their disease course; however, factors predictive of revision surgery and survival outcomes are largely unknown. The goal of this study is to report on survival outcomes as well as factors predictive of revision surgery in this unique patient population. Read More

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http://dx.doi.org/10.1155/2018/6140381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036797PMC

Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru.

J Oncol 2018 19;2018:3924635. Epub 2018 Jun 19.

Pediatric Oncology Unit, Edgardo Rebagliati Martins Hospital, 490 Domingo Cueto Avenue, Lima 11, Peru.

Background: The causes of childhood cancer are not well known, but the advanced age of the parents has been suggested as a risk factor for childhood cancer in several observational studies. In this study, we examine a possible link between parental age and childhood solid tumors.

Methods: We conducted a hospital-based case-control study (310 cases and 620 controls, matched by age and gender) at Rebagliati Hospital, Lima, Peru. Read More

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http://dx.doi.org/10.1155/2018/3924635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029448PMC

and mRNAs Are Higher in Blood from Breast Cancer Patients with Metastatic Disease than Those without.

J Oncol 2018 7;2018:4793498. Epub 2018 Jun 7.

Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Egypt.

Introduction: Breast cancer metastasis occurs when tumor cells dissociate from the primary tumor and migrate to distant organs through the peripheral bloodstream or lymphatic drainage. Circulating tumor cells (CTCs) originate from primary sites or metastases and circulate in the patients' bloodstream. Molecular assays for the detection and molecular characterization of CTCs can serve as a liquid biopsy and can represent an alternative to invasive biopsies as a source of tumor tissue in the metastatic patients. Read More

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http://dx.doi.org/10.1155/2018/4793498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011051PMC
June 2018
9 Reads

Epimutation and Cancer: Carcinogenesis Viewed as Error-Prone Inheritance of Epigenetic Information.

Authors:
Patrick A Riley

J Oncol 2018 3;2018:2645095. Epub 2018 Jun 3.

Totteridge Institute for Advanced Studies, The Grange, Grange Avenue, London N20 8AB, UK.

The epimutation concept, that is, malignancy is a result of deranged patterns of gene expression due to defective epigenetic control, proposes that in the majority of adult cancers the primary (initiating) lesion adversely affects the mechanism of vertical transmission of the epigenetic pattern existing in the stem cells of differentiated tissue. Such an error-prone mechanism will result in deviant gene expression capable of accumulation at each mitosis of the affected stem cell clone. It is argued that a proportion of these proliferation products will express combinations of genes which endow them with malignant properties, such as the ability to transgress tissue boundaries and migrate to distant locations. Read More

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http://dx.doi.org/10.1155/2018/2645095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008765PMC

Complex Karyotype in Hematological Diseases: A 6-Year Single Centre Study from Pakistan.

J Oncol 2018 3;2018:2019239. Epub 2018 Jun 3.

National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, Pakistan.

Background: Most of the hematological disorders are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements. Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients. Though rarer, complex karyotype has been associated with worst prognosis. Read More

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http://dx.doi.org/10.1155/2018/2019239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008829PMC
June 2018
13 Reads

Multifactorial Analysis of Mortality in Screening Detected Lung Cancer.

J Oncol 2018 16;2018:1296246. Epub 2018 May 16.

Division of Thoracic Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

We hypothesized that severity of coronary artery calcification (CAC), emphysema, muscle mass, and fat attenuation can help predict mortality in patients with lung cancer participating in the National Lung Screening Trial (NLST). Following regulatory approval from the Cancer Data Access System (CDAS), all patients diagnosed with lung cancer at the time of the screening study were identified. These subjects were classified into two groups: survivors and nonsurvivors at the conclusion of the NLST trial. Read More

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http://dx.doi.org/10.1155/2018/1296246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976935PMC
May 2018
4 Reads

The Plasticity of CD4CD25FOXP3CD127 T Cells in Patients with Metastatic Renal Cell Carcinoma in the Course of Interferon-Alpha Immunotherapy.

J Oncol 2018 2;2018:7828735. Epub 2018 May 2.

Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Moscow 117997, Russia.

Aims: To examine changes in subpopulation of CD4CD25Foxp3CD127 T lymphocytes (Treg) and their association with the efficiency of the IFN- therapy.

Materials And Methods: Pts with mRCC who had undergone nephrectomy were treated with IFN- at a dose of 6 × 10 U/day three times a week ( = 18). An immunophenotypic analysis of lymphocytes in peripheral blood expressing CD4, CD25, CD127, and Foxp3 antigens could be performed in 18 pts before, 2 weeks, and 2 mo after IFN- therapy and 22 normal volunteers. Read More

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http://dx.doi.org/10.1155/2018/7828735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954933PMC
May 2018
4 Reads

Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary.

J Oncol 2018 7;2018:3519247. Epub 2018 May 7.

Division of Medical Oncology, University of Kentucky, Lexington, KY, USA.

Incidence of low grade well-differentiated neuroendocrine tumors (NET) is on the rise. The North American Neuroendocrine Tumor Society estimates that the United States has more than 150,000 gastroenteropancreatic NET patients. About 10% of metastatic NETs can be unknown primary, and due to their rarity, dedicated treatment algorithms and regimens are not defined. Read More

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https://www.hindawi.com/journals/jo/2018/3519247/
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http://dx.doi.org/10.1155/2018/3519247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964580PMC
May 2018
2 Reads

The Caribbean Community Clinical Oncology Workforce: Analyzing Where We Are Today and Projecting for Tomorrow.

J Oncol 2018 15;2018:7286281. Epub 2018 Apr 15.

National Radiotherapy Centre, St. James, Port of Spain, Trinidad, Trinidad and Tobago.

Purpose: To analyze the current physician clinical oncological workforce within the CARICOM full member states with an aim to make recommendations for building capacity.

Methods: A questionnaire was prepared and emailed to professionals working in oncology in 14 CARICOM full member countries. It was designed to identify the number of specialists providing hematology, medical oncology, and radiotherapy services. Read More

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http://dx.doi.org/10.1155/2018/7286281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925012PMC

Hereditary Nonpolyposis Colorectal Cancer and Cancer Syndromes: Recent Basic and Clinical Discoveries.

J Oncol 2018 23;2018:3979135. Epub 2018 Apr 23.

Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.

Approximately one-third of individuals diagnosed with colorectal cancer have a family history of cancer, suggesting that CRCs may result from a heritable component. Despite the availability of current gene-identification techniques, only 5% of all CRCs emerge from well-identifiable inherited causes for predisposition, including polyposis and nonpolyposis syndromes. Hereditary nonpolyposis colorectal cancer represents a large proportion of cases, and robustly affected patients are at increased risk for early onset, synchronous, and metachronous colorectal malignancies and extracolonic malignancies. Read More

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http://dx.doi.org/10.1155/2018/3979135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937448PMC
April 2018
3 Reads

Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature.

J Oncol 2018 23;2018:3970169. Epub 2018 Apr 23.

3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.

Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy. We present 13 cases diagnosed at two centers in Budapest and review the current literature. The majority of our cases presented with high-risk features initially; two had plasma cell leukemia. Read More

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http://dx.doi.org/10.1155/2018/3970169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937370PMC
April 2018
2 Reads

Health Related Quality of Life of Cancer Patients in Ethiopia.

J Oncol 2018 15;2018:1467595. Epub 2018 Apr 15.

College of Medicine and Health Sciences, School of Pharmacy, Department of Clinical Pharmacy, University of Gondar, Gondar, Ethiopia.

Background: Neoplasm, AKA cancer (Ca), is associated with major morbidity and mortality.

Aim: Measurement of health related quality of life (HRQoL) of Ca patients is uncommon in Ethiopia. The present study determined the HRQoL and its determinants among people living with Ca in north Ethiopia. Read More

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http://dx.doi.org/10.1155/2018/1467595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925207PMC
April 2018
3 Reads

Evaluation of Reirradiation in Locally Advanced Head and Neck Cancers: Toxicity and Early Clinical Outcomes.

J Oncol 2018 26;2018:8183694. Epub 2018 Mar 26.

Department of Otolaryngology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Objectives: Locoregional recurrence is the predominant pattern of treatment failure in advanced head and neck cancers. Reirradiation is a useful modality to treat inoperable head and neck cancer patients with recurrent disease. The aim of the present study was to analyze the treatment toxicity and early clinical outcomes in patients undergoing reirradiation. Read More

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http://dx.doi.org/10.1155/2018/8183694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892228PMC
March 2018
6 Reads

Quality of Life, Depression, and Anxiety in Patients with Uveal Melanoma: A Review.

J Oncol 2018 20;2018:5253109. Epub 2018 Mar 20.

Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 57 Via Roma, Pisa, Italy.

The aim is to summarize current knowledge on both QoL and depressive/anxious symptoms in patients with UM, including studies on the effect on QoL and psychological status of genetic testing related to the risk of metastatic disease. A review from the last 25 years by using the databases "PsycInfo," "Medline," and "Science Direct" was performed. As a total result, eighteen papers were retrieved. Read More

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http://dx.doi.org/10.1155/2018/5253109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883983PMC
March 2018
1 Read

Experience and Expectations of Ovarian Cancer Patients in Australia.

J Oncol 2018 7;2018:7863520. Epub 2018 Mar 7.

Centre for Community-Driven Research, Ultimo, NSW, Australia.

Some of the most significant advances in ovarian cancer treatment have been those that result in improvements in progression-free survival (PFS); however there is little research to understand the value that patients place on accessing therapies that result in PFS as a clinical outcome related to survivorship. This study therefore aimed to understand the experience and expectations of women with ovarian cancer in Australia in relation to quality of life (QoL) and treatment options. An online survey collected demographic information and 13 investigator-derived structured interview questions were developed to understand the experience of women with ovarian cancer, their understanding of terminology associated with their condition, and expectations of future treatment. Read More

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http://dx.doi.org/10.1155/2018/7863520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863331PMC

Intraoral Potentially Malignant Disorders in a Brazilian Oral Pathology Service: Epidemiological, Clinical, and Histopathological Findings.

J Oncol 2018 1;2018:2325808. Epub 2018 Mar 1.

Department of Pathology, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

The aim of this study was to investigate the characteristics of individuals with intraoral potentially malignant disorders (IOPMD) in an oral pathology service in Brazil. Cases were screened based on clinical diagnosis of leukoplakia (LKP), erythroleukoplakia (ELKP), and erythroplakia (EP). Clinical data and information regarding associated factors were gathered from biopsy reports. Read More

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http://dx.doi.org/10.1155/2018/2325808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852874PMC
March 2018
2 Reads

RNA-seq Reveals the Overexpression of IGSF9 in Endometrial Cancer.

J Oncol 2018 14;2018:2439527. Epub 2018 Feb 14.

Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA.

We performed RNA-seq on an Illumina platform for 7 patients with endometrioid endometrial carcinoma for which both tumor tissue and adjacent noncancer tissue were available. A total of 66 genes were differentially expressed with significance level at adjusted value < 0.01. Read More

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http://dx.doi.org/10.1155/2018/2439527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832105PMC
February 2018
5 Reads

The Efficacy of Conventionally Fractionated Radiation in the Management of Osseous Metastases from Metastatic Renal Cell Carcinoma.

J Oncol 2018 9;2018:6384253. Epub 2018 Jan 9.

Department of Radiation Oncology, University of Kansas Cancer Center, Kansas University Medical Center, Kansas City, KS, USA.

Background: There is little data regarding the effectiveness of palliative radiation with conventional fractionation for metastatic renal cell carcinoma (RCC), which has been described as radioresistant. We conducted a retrospective analysis of patients with metastatic bony disease from RCC treated with radiation therapy at our institution.

Methods: Forty patients with histologically confirmed RCC with a total of 53 treatment courses were included. Read More

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http://dx.doi.org/10.1155/2018/6384253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818960PMC
January 2018
1 Read

Corrigendum to "The Current Practice of Screening, Prevention, and Treatment of Androgen-Deprivation-Therapy Induced Osteoporosis in Patients with Prostate Cancer".

J Oncol 2017 3;2017:3432604. Epub 2017 Dec 3.

Division of Geriatric Medicine, Department of Medicine, McMaster University Hamilton Health Sciences, Hamilton, ON, Canada L8S 4K1.

[This corrects the article DOI: 10.1155/2012/958596.]. Read More

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http://dx.doi.org/10.1155/2017/3432604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733234PMC
December 2017
7 Reads

Tumor Lysis Syndrome in Patients with Hematological Malignancies.

J Oncol 2017 2;2017:9684909. Epub 2017 Nov 2.

Department of Hematology & Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Tumor lysis syndrome is a metabolic complication that may follow the initiation of cancer therapy. It commonly occurs in hematological malignant patients particularly non-Hodgkin's lymphoma and acute leukemia due to chemotherapy or spontaneously. It is characterized by a biochemical abnormality such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia and its clinical outcome is directly related to these biochemical abnormalities. Read More

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https://www.hindawi.com/journals/jo/2017/9684909/
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http://dx.doi.org/10.1155/2017/9684909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688348PMC
November 2017
10 Reads

Ki-67 Expression by Immunohistochemistry and Quantitative Real-Time Polymerase Chain Reaction as Predictor of Clinical Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer.

J Oncol 2017 31;2017:6209849. Epub 2017 Oct 31.

Halal Center, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia.

Background: Chemotherapy has become a standard of treatment in managing breast cancer. To achieve proper treatment for the right patients, the predictive marker is needed. Ki-67 is a biomarker of proliferation for solid tumor. Read More

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http://dx.doi.org/10.1155/2017/6209849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684548PMC
October 2017
2 Reads

Level of Concordance of Pre-, Intra-, and Postoperative Staging in Cervical Cancers (TREYA Study).

J Oncol 2017 10;2017:8201462. Epub 2017 Sep 10.

Oncology Department, Treichville University Hospital, Abidjan, Côte d'Ivoire.

Concomitant radiochemotherapy is the therapeutic standard for locally advanced (Ib2 to IVa stage FIGO) cervical cancer. In the absence of a radiotherapy in many of our Sub-Saharan African countries, surgical resection is the only therapeutic method available in hopes of achieving a definite cure. However, criteria for curative surgery are not always met due to preoperative understaging of most of our patients. Read More

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http://dx.doi.org/10.1155/2017/8201462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610798PMC
September 2017
2 Reads

Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer.

J Oncol 2017 17;2017:5035371. Epub 2017 Sep 17.

University of Clermont-Auvergne, UMR 1019 INRA-UCA, Human Nutrition Unit (UNH), ECREIN Team, 63000 Clermont-Ferrand, France.

The microbiota includes different microorganisms consisting of bacteria, fungi, viruses, and protozoa distributed over many human body surfaces including the skin, vagina, gut, and airways, with the highest density found in the intestine. The gut microbiota strongly influences our metabolic, endocrine, and immune systems, as well as both the peripheral and central nervous systems. Recently, a dialogue between the gut and lung microbiota has been discovered, suggesting that changes in one compartment could impact the other compartment, whether in relation to microbial composition or function. Read More

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http://dx.doi.org/10.1155/2017/5035371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623803PMC
September 2017
7 Reads

Trends in the Incidence of Cervical Cancer in Jordan, 2000-2013.

J Oncol 2017 27;2017:6827384. Epub 2017 Aug 27.

Department of Family Medicine, Ministry of Health, Amman, Jordan.

Objectives: To determine the incidence of cervical cancer in Jordan and assess its trend in over a 14-year period (2000-2013).

Methods: This descriptive study was based on secondary analysis of cervical cancer data that are registered in the Jordan Cancer Registry (JCR).

Results: A total of 591 women were diagnosed with cervical cancer in Jordan during the period 2000-2013. Read More

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http://dx.doi.org/10.1155/2017/6827384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592005PMC
August 2017
8 Reads

Improving Efficacy of Bioactive Molecules: An Overview of Potentially Antitumor Phytochemicals and Currently Available Lipid-Based Delivery Systems.

J Oncol 2017 7;2017:7351976. Epub 2017 May 7.

Molecular Oncology and Nutritional Genomics of Cancer, IMDEA Food Institute, CEI UAM+CSIC, Madrid, Spain.

Cancer is among the leading causes of morbidity and mortality worldwide. Many of the chemotherapeutic agents used in cancer treatment exhibit cell toxicity and display teratogenic effect on nontumor cells. Therefore, the search for alternative compounds which are effective against tumor cells but reduce toxicity against nontumor ones is of great importance in the progress or development of cancer treatments. Read More

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http://dx.doi.org/10.1155/2017/7351976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438845PMC
May 2017
12 Reads

Colorectal Cancer in Jordan: Survival Rate and Its Related Factors.

J Oncol 2017 28;2017:3180762. Epub 2017 Mar 28.

Department of Nutrition and Food Technology, Jordan University of Science & Technology, Irbid, Jordan.

. To estimate the survival rate of colorectal cancer (CRC) and determine its predictors among Jordanian patients who were diagnosed in the period of 2005-2010. . Read More

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http://dx.doi.org/10.1155/2017/3180762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387838PMC
March 2017
20 Reads