2,054 results match your criteria Journal of Oncology [Journal]


Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue.

J Oncol 2019 17;2019:7406078. Epub 2019 Mar 17.

Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.

The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. Read More

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http://dx.doi.org/10.1155/2019/7406078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441533PMC

The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components.

J Oncol 2019 12;2019:3671268. Epub 2019 Mar 12.

Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: Gastric adenocarcinoma patients with a neuroendocrine (NE) component are frequently observed in routine practice. Several previous studies have investigated the influence of a NE component on the survival of these patients; however, the results were inconsistent.

Methods: We retrospectively investigated a consecutive series of 95 gastric adenocarcinoma patients with a NE component and 190 gastric adenocarcinoma patients without a NE component. Read More

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https://www.hindawi.com/journals/jo/2019/3671268/
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http://dx.doi.org/10.1155/2019/3671268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434268PMC
March 2019
2 Reads

Clinical Spectrum of Complications Induced by Intravesical Immunotherapy of Bacillus Calmette-Guérin for Bladder Cancer.

J Oncol 2019 10;2019:6230409. Epub 2019 Mar 10.

Urology Department, Peking University Third Hospital, Beijing, China.

Because of its proven efficacy, intravesical Bacillus Calmette-Guérin (BCG) immunotherapy is an important treatment for nonmuscle invasive bladder cancer at high risk of recurrence or progression. However, approximately 8% of patients have to stop BCG instillation as a result of its complications. Complications induced by BCG therapy can have a variety of clinical manifestations. Read More

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http://dx.doi.org/10.1155/2019/6230409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431507PMC
March 2019
1 Read

The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse.

J Oncol 2019 11;2019:1217838. Epub 2019 Mar 11.

Medical Oncology Department, A.C.Camargo Cancer Center, Sao Paulo, 211 Professor Antonio Prudente Street, 01509-900 Liberdade, Brazil.

Background: Treatment of advanced uterine cervical cancer has advanced little in the last 15 years. Although two phase III trials showed survival benefit with the addition of consolidation chemotherapy (CT) after cisplatin-based chemoradiotherapy (RTCT), it is not considered standard of care. We aimed to evaluate the benefit of consolidation CT compared to no additional treatment in patients treated with RTCT. Read More

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http://dx.doi.org/10.1155/2019/1217838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432701PMC
March 2019
1 Read

EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress.

J Oncol 2019 4;2019:8701824. Epub 2019 Mar 4.

Department of Internal Medicine 3, Center of Integrated Oncology (CIO) Cologne-Bonn, University Hospital of Bonn, Germany.

Therapeutic options for advanced stage cholangiocellular carcinoma (CCC) are very limited as of today and patients carry an exceptionally poor overall prognosis. In recent years, increasing evidence has been accumulated to suggest that malignant cells widely show increased intrinsic ROS levels and exhibit altered redox profiles as compared to normal counterparts, opening up potential avenues for therapeutic intervention. This study provides preclinical experimental evidence of therapeutic activity of the curcumin analog EF24 in cholangiocarcinoma models. Read More

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http://dx.doi.org/10.1155/2019/8701824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425401PMC
March 2019
2 Reads

Tubal Origin of "Ovarian" Low-Grade Serous Carcinoma: A Gene Expression Profile Study.

J Oncol 2019 5;2019:8659754. Epub 2019 Mar 5.

Department of Obstetrics and Gynecology, Henan Provincial People's Hospital, Zhengzhou, China.

Objective: Ovarian low-grade serous carcinomas are thought to evolve in a stepwise fashion from ovarian epithelial inclusions, serous cystadenomas, and serous borderline tumors. Our previous study with clinicopathological approach showed that the majority ovarian epithelial inclusions are derived from the fallopian tubal epithelia rather than from ovarian surface epithelia. This study was designed to gain further insight into the cellular origin of ovarian low-grade serous carcinomas by differential gene expression profiling studies. Read More

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https://www.hindawi.com/journals/jo/2019/8659754/
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http://dx.doi.org/10.1155/2019/8659754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425354PMC
March 2019
13 Reads

Colorectal Cancer Characteristics and Outcomes after Solid Organ Transplantation.

J Oncol 2019 28;2019:5796108. Epub 2019 Feb 28.

Division of Hematology and Oncology, University of Iowa, Iowa City, IA, USA.

Background: Individuals after solid organ transplant may develop secondary malignancies. In our clinical practice, we noted an increasing number of individuals who developed colorectal cancers after solid organ transplantation. The primary aim of this study was to describe the characteristics and outcomes of the patients who developed colorectal cancer after solid organ transplant. Read More

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http://dx.doi.org/10.1155/2019/5796108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421000PMC
February 2019
2 Reads

Current Challenges in Cancer Immunotherapy: Multimodal Approaches to Improve Efficacy and Patient Response Rates.

J Oncol 2019 28;2019:4508794. Epub 2019 Feb 28.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

Cancer immunotherapy is a promising innovative treatment for many forms of cancer, particularly melanoma. Although immunotherapy has been shown to be efficacious, patient response rates vary and, more often than not, only a small subset of the patients within a large cohort respond favourably to the treatment. This issue is particularly concerning and becomes a challenge of immunotherapy to improve the effectiveness and patient response rates. Read More

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http://dx.doi.org/10.1155/2019/4508794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420990PMC
February 2019
1 Read

Use of Antimetastatic SOD3-Mimetic Albumin as a Primer in Triple Negative Breast Cancer.

J Oncol 2019 28;2019:3253696. Epub 2019 Feb 28.

Cancer Biology and Immunotherapies, Sanford Research, Sioux Falls, 57104 SD, USA.

Of the deaths attributed to cancer, 90% are due to metastasis. Treatments that prevent or cure metastasis remain elusive. Low expression of extracellular superoxide dismutase (EcSOD or SOD3) has been associated with poor outcomes and increased metastatic potential in multiple types of cancer. Read More

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http://dx.doi.org/10.1155/2019/3253696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420975PMC
February 2019
2 Reads

Interaction of Anticancer Drugs with Human Organic Anion Transporter hOAT4.

J Oncol 2019 28;2019:1951786. Epub 2019 Feb 28.

Departments of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, NJ, USA.

Human organic anion transporter 4 (hOAT4) belongs to a family of multispecific organic anion transporters that play critical roles in the disposition of numerous drugs and therefore are the major sites for drug-drug interaction. Drug-drug interactions contribute significantly to the individual variation in drug response. hOAT4 is expressed in the kidney and placenta. Read More

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http://dx.doi.org/10.1155/2019/1951786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421026PMC
February 2019
1 Read

Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a -Mutant Zebrafish Model.

J Oncol 2019 26;2019:9218251. Epub 2019 Feb 26.

Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, Raleigh, NC, USA.

Successful cell replication requires both cell cycle completion and accurate chromosomal segregation. The tumor suppressor BRCA2 is positioned to influence both of these outcomes, and thereby influence genomic integrity, during meiotic and mitotic cell cycles. Accordingly, mutations in induce chromosomal abnormalities and disrupt cell cycle progression in both germ cells and somatic cells. Read More

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http://dx.doi.org/10.1155/2019/9218251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413366PMC
February 2019
1 Read

Liver Metastases and Histological Growth Patterns: Biological Behavior and Potential Clinical Implications-Another Path to Individualized Medicine?

J Oncol 2019 25;2019:6280347. Epub 2019 Feb 25.

Biophysics Institute, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

Colorectal cancer is a major health burden and despite the recent advances in healthcare and screening programs, a great percentage of patients already present metastases once their disease is found. In those cases, liver surgery has an essential role, but even with neoadjuvant chemotherapy there is a high rate of intrahepatic recurrence. New prognostic factors are needed in order to decide the best surgical approach considering the biological behavior of the tumors in order to tailor the used therapies, moving towards individualized medicine/treatment. Read More

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http://dx.doi.org/10.1155/2019/6280347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413382PMC
February 2019
3 Reads

CAPTEM in Metastatic Well-Differentiated Intermediate to High Grade Neuroendocrine Tumors: A Single Centre Experience.

J Oncol 2019 20;2019:9032753. Epub 2019 Feb 20.

Department of Cancer Medicine, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia.

Introduction: Capecitabine-temozolomide (CAPTEM) has significant activity in patients (pts) with metastatic low grade pancreatic neuroendocrine tumors (NETs). However, there is limited data regarding its activity in pts with metastatic well-differentiated intermediate and high grade pancreatic and nonpancreatic NETs. The objective of this study was to assess the functional imaging response, survival, and tolerability of CAPTEM in this population. Read More

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http://dx.doi.org/10.1155/2019/9032753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402194PMC
February 2019

Colon Cancer Sidedness, Presentation, and Survival at Different Stages.

J Oncol 2019 21;2019:4315032. Epub 2019 Feb 21.

University of Nevada, Reno School of Medicine, Department of Internal Medicine, 1155 Mill Street, W-11, Reno, NV 89502, USA.

Background: Several prognostic factors have been used to guide therapy for colon cancer (CC). However, the relationship between CC laterality (sidedness) and prognosis remains under investigation.

Objectives: To assess the effect of laterality on CC presentation and survival, using a Surveillance, Epidemiology, and End Results (SEER) population-based cohort. Read More

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http://dx.doi.org/10.1155/2019/4315032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409047PMC
February 2019
1 Read

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications.

J Oncol 2019 21;2019:3958908. Epub 2019 Feb 21.

Cancer Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.

Tumor progression through immune evasion is a major challenge in cancer therapy. Recent studies revealed that enhanced PD-L1 expression in cancer stem cells is linked to immune evasion. Understanding the mechanisms behind this PD-L1 overexpression in cancer stem cells is critical for developing more effective strategies for preventing immune evasion and increasing the efficacy of anti-PD-1/PD-L1 therapy. Read More

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http://dx.doi.org/10.1155/2019/3958908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409026PMC
February 2019

Can We Increase the Resection Rate by Minimally Invasive Approach? Experience from 100 Minimally Invasive Esophagectomies.

J Oncol 2019 24;2019:3809383. Epub 2019 Feb 24.

Department of Surgery, Central Finland Central Hospital, 40620 Jyväskylä, Finland.

Background: Whether we can increase the resection rate of esophageal cancer by minimally invasive esophagectomy (MIE) is unknown. The aim was to report the number and results of MIE in high-risk patients considered unsuitable for open surgery and compare these results to other operated patients and to high-risk patients not undergoing surgery.

Methods: At Central Finland Central Hospital, between September 2012 and July 2018, the number of operated MIEs was 100. Read More

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http://dx.doi.org/10.1155/2019/3809383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409017PMC
February 2019

Mechanism for Regulation of Melanoma Cell Death via Activation of Thermo-TRPV4 and TRPV2.

J Oncol 2019 7;2019:7362875. Epub 2019 Feb 7.

Institute of Cancer Stem Cell, Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian 116044, China.

Background: Thermo-TRPs (temperature-sensitive transient receptor potential channels) belong to the TRP (transient receptor potential) channel superfamily. Emerging evidence implied that thermo-TRPs have been involved in regulation of cell fate in certain tumors. However, their distribution profiles and roles in melanoma remain incompletely understood. Read More

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https://www.hindawi.com/journals/jo/2019/7362875/
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http://dx.doi.org/10.1155/2019/7362875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383420PMC
February 2019
2 Reads

Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System.

J Oncol 2019 3;2019:5245034. Epub 2019 Feb 3.

Division of Pediatric Hematology-Oncology, Department of Pediatrics, Moores Cancer Center, University of California, San Diego, CA, USA.

Cancer immunotherapy, including immune checkpoint blockade and adoptive CAR T-cell therapy, has clearly established itself as an important modality to treat melanoma and other malignancies. Despite the tremendous clinical success of immunotherapy over other cancer treatments, this approach has shown substantial benefit to only some of the patients while the rest of the patients have not responded due to immune evasion. In recent years, a combination of cancer immunotherapy together with existing anticancer treatments has gained significant attention and has been extensively investigated in preclinical or clinical studies. Read More

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http://dx.doi.org/10.1155/2019/5245034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377965PMC
February 2019
3 Reads

From Whole-Brain Radiotherapy to Immunotherapy: A Multidisciplinary Approach for Patients with Brain Metastases from NSCLC.

J Oncol 2019 3;2019:3267409. Epub 2019 Feb 3.

National and Kapodistrian University of Athens, Medical School, Radiation Oncology Unit, 1st Department of Radiology, Aretaieion University Hospital, Greece.

Non-small cell lung cancer patients with brain metastases have a multitude of treatment options, but there is currently no international and multidisciplinary consensus concerning their optimal treatment. Local therapies have the principal role, especially in symptomatic patients. Advances in surgery and radiation therapy manage considerable local control. Read More

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http://dx.doi.org/10.1155/2019/3267409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378013PMC
February 2019
4 Reads

Low GAS5 Levels as a Predictor of Poor Survival in Patients with Lower-Grade Gliomas.

J Oncol 2019 3;2019:1785042. Epub 2019 Feb 3.

Institute of Radiation Biology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Introduction: Gliomas are infiltrative neoplasms of a highly invasive nature. Different stages of gliomas feature distinct genomic, genetic, and epigenetic changes. The long noncoding RNA Growth Arrest Specific Transcript 5 (GAS5) is an identified tumour suppressor involved in several cancers. Read More

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https://www.hindawi.com/journals/jo/2019/1785042/
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http://dx.doi.org/10.1155/2019/1785042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377997PMC
February 2019
3 Reads

Interaction of CD200 Overexpression on Tumor Cells with CD200R1 Overexpression on Stromal Cells: An Escape from the Host Immune Response in Rectal Cancer Patients.

J Oncol 2019 21;2019:5689464. Epub 2019 Jan 21.

Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

CD200 imparts an immunoregulatory signal through its receptor, CD200R1, leading to the suppression of tumor specific immunity. The mechanism of CD200:CD200R1 signaling pathway is still uncertain. Our aim was to investigate the expression and localization of CD200 and its receptor CD200R1 and their clinical significance in rectal cancer patients. Read More

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http://dx.doi.org/10.1155/2019/5689464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360612PMC
January 2019

Selected Office Based Anticancer Treatment Strategies.

Authors:
Jesse A Stoff

J Oncol 2019 15;2019:7462513. Epub 2019 Jan 15.

Integrative Medicine of New York, 265 Post Ave., Suite 380, Westbury, NY 11590, USA.

Over the years, the treatment of patients with cancer has varied widely as much because of recent advancements in science and medicine as the philosophies that belie their use. This paper briefly describes many of the prevailing approaches in use today with an attempt to offer some perspective of how to apply these disparate methodologies so that they may be more effectively integrated, resulting in consistently better clinical responses. Read More

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http://dx.doi.org/10.1155/2019/7462513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350558PMC
January 2019

Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells.

J Oncol 2019 6;2019:6164807. Epub 2019 Jan 6.

Department of Biological Sciences, Pilani Campus, BITS, Pilani, Rajasthan 333031, India.

Mutations in p53, especially gain of function (GOF) mutations, are highly frequent in lung cancers and are known to facilitate tumor aggressiveness. Yet, the links between mutant GOF-p53 and lung cancers are not well established. In the present study, we set to examine how we can better sensitize resistant GOF-p53 lung cancer cells through modulation of cellular protein degradation machineries, proteasome and autophagy. Read More

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https://www.hindawi.com/journals/jo/2019/6164807/
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http://dx.doi.org/10.1155/2019/6164807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339715PMC
January 2019
4 Reads

Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer.

J Oncol 2019 6;2019:1925315. Epub 2019 Jan 6.

Cardiovascular and Gastroenterological Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.

Purpose: Platelet derived growth factor-BB (PDGF-BB) has emerged as one of the key cytokines in malignant transformation of different cells. PDGF-BB also exhibits a potent mitogenic effect on liver cells; studies have advocated clinical implications of monitoring serum PDGF-BB (sPDGF-BB) in patients with liver disease. We thus investigated the predictive relevance of perioperative sPDGF-BB after curative resection of hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1155/2019/1925315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339767PMC
January 2019
1 Read

The Financial Impact of Hypofractionated Radiation for Localized Prostate Cancer in the United States.

J Oncol 2019 2;2019:8170428. Epub 2019 Jan 2.

Institute of Oncology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel.

Background: Until recently, dose intensified radiotherapy was the standard radiation method for localized prostate cancer. Multiple studies have demonstrated similar efficacy and tolerability with moderate hypofractionation. In recent years there has been an increasing focus placed on understanding the cost and value of cancer care. Read More

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http://dx.doi.org/10.1155/2019/8170428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334370PMC
January 2019
2 Reads

UBE2C Induces Cisplatin Resistance via ZEB1/2-Dependent Upregulation of ABCG2 and ERCC1 in NSCLC Cells.

J Oncol 2019 1;2019:8607859. Epub 2019 Jan 1.

Cancer Research Institute, Binzhou Medical University Hospital, Binzhou 256603, China.

Objectives: Cisplatin (DDP) is one of the most commonly used chemotherapeutic drugs for several cancers, including non-small-cell lung cancer (NSCLC). However, resistance to DDP eventually develops, limiting its further application. New therapy targets are urgently needed to reverse DDP resistance. Read More

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https://www.hindawi.com/journals/jo/2019/8607859/
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http://dx.doi.org/10.1155/2019/8607859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333017PMC
January 2019
4 Reads

Current and Emerging Targets in Immunotherapy for Osteosarcoma.

J Oncol 2019 1;2019:7035045. Epub 2019 Jan 1.

Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa 920-8640, Japan.

Osteosarcoma is the most common primary malignancy of bone. Although outcomes of patients with osteosarcoma have improved since the introduction of chemotherapy, outcomes of metastatic or unresectable osteosarcomas are still unsatisfactory. To improve osteosarcoma outcomes, the development of novel systemic therapies for osteosarcoma is needed. Read More

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http://dx.doi.org/10.1155/2019/7035045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332920PMC
January 2019

The Therapeutic Strategies of Regulatory T Cells in Malignancies and Stem Cell Transplantations.

J Oncol 2019 1;2019:5981054. Epub 2019 Jan 1.

College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.

Regulatory T cells (Treg cells) are considered one of the main dynamic cell types within the immune system. Because Treg cells suppress immune responses, they have potential roles in immunological self-tolerance and may help to maintain immune homeostasis. Promoting Treg cell function and increasing their numbers might be useful in treating autoimmune disorders, as well as preventing allograft rejection. Read More

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http://dx.doi.org/10.1155/2019/5981054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332959PMC
January 2019

Prognostic Value of CD133 and SOX2 in Advanced Cancer.

J Oncol 2019 1;2019:3905817. Epub 2019 Jan 1.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Road, Shanghai 200071, China.

Background: The prognostic value of CD133 and SOX2 expression in advanced cancer remains unclear. This study was first conducted to investigate the association between CD133 or SOX2 positivity and clinical outcomes for advanced cancer patients.

Methods: Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated to evaluate the correlation between CD133 or SOX2 positivity and overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), cancer-specific survival (CSS), or recurrence-free survival (RFS) from multivariable analysis. Read More

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http://dx.doi.org/10.1155/2019/3905817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332999PMC
January 2019
3 Reads

Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome-Wide Association Study.

J Oncol 2018 18;2018:6594169. Epub 2018 Dec 18.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China.

NM23 expression is closely associated with hepatocellular carcinoma (HCC) recurrence, but the hereditary factors influencing NM23 levels are unknown. Using public database, the diagnostic value of in HCC was investigated. A total of 424 hepatitis B virus- (HBV-) related HCC patients were enrolled to perform a genome-wide association study for identifying candidate variants associated with NM23 expression level. Read More

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http://dx.doi.org/10.1155/2018/6594169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312618PMC
December 2018
6 Reads

Homocysteine and Digestive Tract Cancer Risk: A Dose-Response Meta-Analysis.

J Oncol 2018 18;2018:3720684. Epub 2018 Dec 18.

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Homocysteine, a key component in one-carbon metabolism, is of great importance in remethylation. Many epidemiologic studies have assessed the association between homocysteine and risk of digestive tract cancer, but the results are inconsistent.

Objective: The objective of our meta-analysis is to assess the association between homocysteine and digestive tract cancer risk. Read More

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http://dx.doi.org/10.1155/2018/3720684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312580PMC
December 2018
2 Reads

The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma.

J Oncol 2018 18;2018:1953571. Epub 2018 Dec 18.

Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea.

Purpose: This study aimed to determine whether baseline blood inflammatory markers can predict progression-free survival (PFS) and overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC).

Methods: The study included 158 patients with mRCC treated with first-line targeted therapy between 2002 and 2016. A multivariable cox proportional hazards model identified inflammatory factors that predict PFS and OS. Read More

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http://dx.doi.org/10.1155/2018/1953571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312581PMC
December 2018
2 Reads

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer.

J Oncol 2018 17;2018:2937012. Epub 2018 Dec 17.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.

The role of PD-L1 as a prognostic and predictive biomarker is an area of great interest. However, there is a lack of consensus on how to deliver PD-L1 as a clinical biomarker. At the heart of this conundrum is the subjective scoring of PD-L1 IHC in most studies to date. Read More

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http://dx.doi.org/10.1155/2018/2937012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311859PMC
December 2018
5 Reads

Secretory High-Mobility Group Box 1 Protein Affects Regulatory T Cell Differentiation in Neuroblastoma Microenvironment .

J Oncol 2018 16;2018:7946021. Epub 2018 Dec 16.

Hematology and Oncology Division, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Neuroblastoma (NB) is the most common extracranial tumor of childhood with poor prognosis in a high-risk group. An obstacle in the development of treatment for solid tumors is the immunosuppressive nature of the tumor microenvironment (TME). Regulatory T cells (Tregs) represent a T cell subset with specialized function in immune suppression and maintaining self-tolerance. Read More

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http://dx.doi.org/10.1155/2018/7946021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311239PMC
December 2018
4 Reads

Transforming of the Tumor Microenvironment: Implications for TGF- Inhibition in the Context of Immune-Checkpoint Therapy.

Authors:
Stefanie Löffek

J Oncol 2018 2;2018:9732939. Epub 2018 Dec 2.

Skin Cancer Unit of the Dermatology Department, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, and the German Cancer Consortium (DKTK), 45147 Essen, Germany.

Significant breakthroughs have been achieved in the fields of oncogenic signaling inhibition and particularly immune-checkpoint blockade has triggered substantial enthusiasm during the last decade. Antibody-mediated blockade of negative immune-checkpoint molecules (e.g. Read More

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https://www.hindawi.com/journals/jo/2018/9732939/
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http://dx.doi.org/10.1155/2018/9732939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304495PMC
December 2018
9 Reads

Quantitative Metastatic Lymph Node Regions on Magnetic Resonance Imaging Are Superior to AJCC N Classification for the Prognosis of Nasopharyngeal Carcinoma.

J Oncol 2018 2;2018:9172585. Epub 2018 Dec 2.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Purpose: Quantitative lymph node burden has been demonstrated to be a critical prognosticator in various malignancies, yet it was seldom explored in nasopharyngeal carcinoma (NPC). This study aimed to investigate the impact of the number of metastatic lymph node regions (LRN) on prognosis of NPC and to establish a new N classification system based on LRN.

Methods And Materials: The magnetic resonance images (MRI) of 354 nondisseminated NPC patients before radical treatment were retrospectively evaluated. Read More

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http://dx.doi.org/10.1155/2018/9172585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304546PMC
December 2018
3 Reads

Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited.

J Oncol 2018 4;2018:6214838. Epub 2018 Dec 4.

Department of Surgery, University of Florida Health Sciences Center, Gainesville, FL 32610, USA.

Membrane transporters fulfill essential roles in maintaining normal cellular function in health. In cancer, transporters likewise facilitate the aberrant characteristics typical of proliferating tumor cells. Pancreatic ductal adenocarcinoma is remarkable in its aggressiveness, and its metabolism is supported by a variety of membrane transporters. Read More

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http://dx.doi.org/10.1155/2018/6214838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304534PMC
December 2018
3 Reads

Exploration of the Combination of PLK1 Inhibition with Immunotherapy in Cancer Treatment.

J Oncol 2018 2;2018:3979527. Epub 2018 Dec 2.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Background: PLK1 overexpression is oncogenic and is associated with poor prognosis in various cancers. However, the current PLK1 inhibitors have achieved limited clinical successes. On the other hand, although immunotherapies are demonstrating efficacy in treating many refractory cancers, a substantial number of patients do not respond to such therapies. Read More

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http://dx.doi.org/10.1155/2018/3979527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304487PMC
December 2018
2 Reads

Efficacy of Immunotherapy in Patients with Metastatic Mucosal or Uveal Melanoma.

J Oncol 2018 2;2018:1908065. Epub 2018 Dec 2.

Dermatology Department, Institute for Research and Innovation in Biomedicine, INSERM 1234, Rouen University Hospital, University of Normandie, Rouen, France.

Background: The objective was to assess the response rate and survival of patients with metastatic mucosal melanoma (MM) and uveal melanoma (UM) treated with anti-CTLA-4 or anti-PD-1 monoclonal antibodies (mAbs).

Methods: A multicenter retrospective study was performed in 25 dermatology departments in France. All patients with stage III-C to IV MM or UM who were treated with anti-CTLA-4 or anti-PD-1 mAbs between 2008 and 2016 were included and compared after adjustment for main prognostic factors with a second cohort of patients treated with chemotherapy. Read More

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https://www.hindawi.com/journals/jo/2018/1908065/
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http://dx.doi.org/10.1155/2018/1908065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304636PMC
December 2018
18 Reads

Resection of Liver Metastases: A Treatment Provides a Long-Term Survival Benefit for Patients with Advanced Pancreatic Neuroendocrine Tumors: .

J Oncol 2018 14;2018:6273947. Epub 2018 Nov 14.

Pancreatic Surgery Department, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.

Purpose: Nonsurgical therapies, including biotherapy, chemotherapy, and liver-directed therapy, provided a limit survival benefit for PNET patients with hepatic metastases. With the development of liver resection technique, there was a controversy on whether to perform a liver resection for these patients.

Methods: A computerized search was made of the Medline/PubMed, EMbase, Cochrane Library, and SinoMed (CBM) before March 2018. Read More

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http://dx.doi.org/10.1155/2018/6273947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261248PMC
November 2018
7 Reads

Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.

J Oncol 2018 8;2018:6301980. Epub 2018 Nov 8.

Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil.

Introduction: Differential expression of genes encoding cytochrome P450 (CYP) and other oxygenases enzymes involved in biotransformation mechanisms of endogenous and exogenous compounds can lead to oral tumor development.

Objective: We aimed to identify the expression profile of these genes, searching for susceptibility biomarkers in oral squamous cell carcinoma.

Patients And Methods: Sixteen oral squamous cell carcinoma samples were included in this study (eight tumor and eight adjacent non-tumor tissues). Read More

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https://www.hindawi.com/journals/jo/2018/6301980/
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http://dx.doi.org/10.1155/2018/6301980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250001PMC
November 2018
13 Reads

PPAR Enhances Cancer Cell Chemotherapy Sensitivity by Autophagy Induction.

J Oncol 2018 4;2018:6458537. Epub 2018 Nov 4.

Department of Oncology, The Affiliated Wujin People's hospital, Jiangsu University, Changzhou, Jiangsu Province, China.

PPAR (peroxisome-proliferator-activated receptor ) plays a critical role in regulation of inflammation and cancer, while the regulatory mechanism of PPAR on cancer cell autophagy is still unclear. Here we found that PPAR enhanced autophagy in HEK293T, SW480, and Hela cell lines, which was independent of PPAR transcription activity. PPAR induced antiapoptotic Bcl2 protein degradation resulting in release of the Beclin-1/VPS34 complex. Read More

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http://dx.doi.org/10.1155/2018/6458537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241347PMC
November 2018
2 Reads

Small or Non-Small Cell Lung Cancer Based Therapy for Treatment of Large Cell Neuroendocrine Cancer of The Lung? University of Cincinnati Experience.

J Oncol 2018 1;2018:9761826. Epub 2018 Nov 1.

Department of Hematology-Oncology, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Ave, Cincinnati, OH 45267, USA.

Large cell neuroendocrine cancer (LCNEC) of the lung exhibits morphological and immunohistochemical characteristics of both neuroendocrine and large cell carcinomas. No defined optimal therapy has been described for this subset of patients and the question of whether these patients should be treated with non-small cell lung cancer (NSCLC) treatment protocols, according to the National Comprehensive Cancer Network (NCCN) guidelines, or with small cell lung cancer (SCLC) due to histological and clinical similarities is still uncertain. We conducted a retrospective review of patients identified with diagnosis of LCNEC of the lung at the University of Cincinnati Cancer Center from the year 2002 to 2012 to determine which treatment approach resulted in improved outcomes in this rare category of disease. Read More

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https://www.hindawi.com/journals/jo/2018/9761826/
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http://dx.doi.org/10.1155/2018/9761826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236557PMC
November 2018
3 Reads

Risk Factors for Fatal Pulmonary Hemorrhage following Concurrent Chemoradiotherapy in Stage 3B/C Squamous-Cell Lung Carcinoma Patients.

J Oncol 2018 1;2018:4518935. Epub 2018 Nov 1.

Bahcesehir University Medical Faculty, Department of Radiation Oncology, Istanbul, Turkey.

We aimed to identify the fatal pulmonary hemorrhage- (FPH-) related risk factors in stage 3B/C squamous-cell lung carcinoma (SqCLC) patients treated with definitive concurrent chemoradiotherapy (C-CRT). Medical records of 505 stage 3B/C SqCLC patients who underwent 66 Gy radiotherapy plus 1-3 cycles of concurrent chemotherapy with available pretreatment thoracic computerized tomography scans were retrospectively analyzed. Primary end-point was the identification of FPH-related risk factors. Read More

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http://dx.doi.org/10.1155/2018/4518935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236701PMC
November 2018
2 Reads

Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy.

J Oncol 2018 25;2018:8653489. Epub 2018 Oct 25.

Division of Clinical Physiology and Therapeutics, Keio University, Faculty of Pharmacy, 1-5-30, Shiabakoen, Minato-Ku, Tokyo, Japan.

Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or adoptive T cell therapies, have contributed to better outcomes in cancer patients. However, there are still many cancers with no cure. Therefore, combinations of several treatment strategies are being explored, and enhancing anticancer immunity will play an important role to combat the disease. Read More

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http://dx.doi.org/10.1155/2018/8653489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222238PMC
October 2018
2 Reads

Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer.

J Oncol 2018 16;2018:3812581. Epub 2018 Oct 16.

Department of System Biology, Unit of Biochemistry and Molecular Biology, University of Alcalá, Alcalá de Henares, Spain.

We reported that insulin receptor substrate 4 (IRS-4) levels increased in tissue from colorectal cancer (CRC) patients and promoted retinoblastoma-cyclin-dependent kinase activation. The aim of the present study was to evaluate the effect of IRS-4 on IGF-1 receptor pathway and its impact on procaspase 3 and PARP expression in RKO and HepG2 cancer cell lines. The results obtained were compared with those obtained from biopsies of patients with CRC (n = 18), tubulovillous adenomas (TA) (n = 2) and in matched adjacent normal colorectal (MANC) tissue (n = 20). Read More

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https://www.hindawi.com/journals/jo/2018/3812581/
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http://dx.doi.org/10.1155/2018/3812581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206579PMC
October 2018
15 Reads

Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA.

J Oncol 2018 11;2018:2183179. Epub 2018 Oct 11.

Department of Emergency Medicine, Inha University School of Medicine, Incheon, Republic of Korea.

Background/aims: Febrile neutropenia is considered as one of the most important and potentially life-threatening oncologic emergencies, which requires prompt medical assessment and treatment with antibiotics. This was a single-center retrospective study that investigated the prognostic factors predicting poor outcome in patients with cancer who presented with febrile neutropenia at the emergency department (ED).

Methods: The medical records of patients diagnosed with febrile neutropenia in the ED from January 2014 to December 2017 were reviewed. Read More

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https://www.hindawi.com/journals/jo/2018/2183179/
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http://dx.doi.org/10.1155/2018/2183179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201329PMC
October 2018
9 Reads

Treatment-Related Adverse Effects in Lung Cancer Patients after Stereotactic Ablative Radiation Therapy.

J Oncol 2018 4;2018:6483626. Epub 2018 Oct 4.

Cancer Research Institute and School of Health Sciences, University of South Australia, Adelaide SA 5001, Australia.

Introduction: Lung cancer is a disease which, despite the advancements in treatment, still has a very poor 5-year survival rate. Stereotactic ablative radiation therapy (SABR) is a highly advanced, sophisticated, and safe treatment which allows patients with early stage lung cancer to be treated effectively without invasive procedures and with excellent clinical outcomes. Avoiding surgery minimises morbidity and recovery time, bettering patients' quality of life. Read More

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http://dx.doi.org/10.1155/2018/6483626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193322PMC
October 2018
4 Reads

Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer.

J Oncol 2018 1;2018:3725837. Epub 2018 Oct 1.

Division of Radiation Oncology, Regional Cancer Centre, Trivandrum, India.

Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. Read More

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https://www.hindawi.com/journals/jo/2018/3725837/
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http://dx.doi.org/10.1155/2018/3725837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188855PMC
October 2018
14 Reads

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis.

J Oncol 2018 26;2018:3098940. Epub 2018 Sep 26.

Department of Dermatovenereology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia.

Background: BCC is currently the most common type of skin cancer in humans. Although having a low-grade malignancy and metastatic potential, BCC is locally aggressive and destructive. Despite numerous studies, the origin of BCC, whether arising from the follicular or interfollicular layer, remains controversial. Read More

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http://dx.doi.org/10.1155/2018/3098940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178174PMC
September 2018
5 Reads