2,033 results match your criteria Journal of Oncology [Journal]


Selected Office Based Anticancer Treatment Strategies.

Authors:
Jesse A Stoff

J Oncol 2019 15;2019:7462513. Epub 2019 Jan 15.

Integrative Medicine of New York, 265 Post Ave., Suite 380, Westbury, NY 11590, USA.

Over the years, the treatment of patients with cancer has varied widely as much because of recent advancements in science and medicine as the philosophies that belie their use. This paper briefly describes many of the prevailing approaches in use today with an attempt to offer some perspective of how to apply these disparate methodologies so that they may be more effectively integrated, resulting in consistently better clinical responses. Read More

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http://dx.doi.org/10.1155/2019/7462513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350558PMC
January 2019

Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells.

J Oncol 2019 6;2019:6164807. Epub 2019 Jan 6.

Department of Biological Sciences, Pilani Campus, BITS, Pilani, Rajasthan 333031, India.

Mutations in p53, especially gain of function (GOF) mutations, are highly frequent in lung cancers and are known to facilitate tumor aggressiveness. Yet, the links between mutant GOF-p53 and lung cancers are not well established. In the present study, we set to examine how we can better sensitize resistant GOF-p53 lung cancer cells through modulation of cellular protein degradation machineries, proteasome and autophagy. Read More

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https://www.hindawi.com/journals/jo/2019/6164807/
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http://dx.doi.org/10.1155/2019/6164807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339715PMC
January 2019
1 Read

Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer.

J Oncol 2019 6;2019:1925315. Epub 2019 Jan 6.

Cardiovascular and Gastroenterological Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.

Purpose: Platelet derived growth factor-BB (PDGF-BB) has emerged as one of the key cytokines in malignant transformation of different cells. PDGF-BB also exhibits a potent mitogenic effect on liver cells; studies have advocated clinical implications of monitoring serum PDGF-BB (sPDGF-BB) in patients with liver disease. We thus investigated the predictive relevance of perioperative sPDGF-BB after curative resection of hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1155/2019/1925315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339767PMC
January 2019
1 Read

The Financial Impact of Hypofractionated Radiation for Localized Prostate Cancer in the United States.

J Oncol 2019 2;2019:8170428. Epub 2019 Jan 2.

Institute of Oncology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel.

Background: Until recently, dose intensified radiotherapy was the standard radiation method for localized prostate cancer. Multiple studies have demonstrated similar efficacy and tolerability with moderate hypofractionation. In recent years there has been an increasing focus placed on understanding the cost and value of cancer care. Read More

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http://dx.doi.org/10.1155/2019/8170428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334370PMC
January 2019
1 Read

UBE2C Induces Cisplatin Resistance via ZEB1/2-Dependent Upregulation of ABCG2 and ERCC1 in NSCLC Cells.

J Oncol 2019 1;2019:8607859. Epub 2019 Jan 1.

Cancer Research Institute, Binzhou Medical University Hospital, Binzhou 256603, China.

Objectives: Cisplatin (DDP) is one of the most commonly used chemotherapeutic drugs for several cancers, including non-small-cell lung cancer (NSCLC). However, resistance to DDP eventually develops, limiting its further application. New therapy targets are urgently needed to reverse DDP resistance. Read More

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https://www.hindawi.com/journals/jo/2019/8607859/
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http://dx.doi.org/10.1155/2019/8607859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333017PMC
January 2019
2 Reads

Current and Emerging Targets in Immunotherapy for Osteosarcoma.

J Oncol 2019 1;2019:7035045. Epub 2019 Jan 1.

Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa 920-8640, Japan.

Osteosarcoma is the most common primary malignancy of bone. Although outcomes of patients with osteosarcoma have improved since the introduction of chemotherapy, outcomes of metastatic or unresectable osteosarcomas are still unsatisfactory. To improve osteosarcoma outcomes, the development of novel systemic therapies for osteosarcoma is needed. Read More

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http://dx.doi.org/10.1155/2019/7035045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332920PMC
January 2019

The Therapeutic Strategies of Regulatory T Cells in Malignancies and Stem Cell Transplantations.

J Oncol 2019 1;2019:5981054. Epub 2019 Jan 1.

College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.

Regulatory T cells (Treg cells) are considered one of the main dynamic cell types within the immune system. Because Treg cells suppress immune responses, they have potential roles in immunological self-tolerance and may help to maintain immune homeostasis. Promoting Treg cell function and increasing their numbers might be useful in treating autoimmune disorders, as well as preventing allograft rejection. Read More

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http://dx.doi.org/10.1155/2019/5981054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332959PMC
January 2019

Prognostic Value of CD133 and SOX2 in Advanced Cancer.

J Oncol 2019 1;2019:3905817. Epub 2019 Jan 1.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Road, Shanghai 200071, China.

Background: The prognostic value of CD133 and SOX2 expression in advanced cancer remains unclear. This study was first conducted to investigate the association between CD133 or SOX2 positivity and clinical outcomes for advanced cancer patients.

Methods: Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated to evaluate the correlation between CD133 or SOX2 positivity and overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), cancer-specific survival (CSS), or recurrence-free survival (RFS) from multivariable analysis. Read More

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http://dx.doi.org/10.1155/2019/3905817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332999PMC
January 2019

Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome-Wide Association Study.

J Oncol 2018 18;2018:6594169. Epub 2018 Dec 18.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China.

NM23 expression is closely associated with hepatocellular carcinoma (HCC) recurrence, but the hereditary factors influencing NM23 levels are unknown. Using public database, the diagnostic value of in HCC was investigated. A total of 424 hepatitis B virus- (HBV-) related HCC patients were enrolled to perform a genome-wide association study for identifying candidate variants associated with NM23 expression level. Read More

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http://dx.doi.org/10.1155/2018/6594169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312618PMC
December 2018
1 Read

Homocysteine and Digestive Tract Cancer Risk: A Dose-Response Meta-Analysis.

J Oncol 2018 18;2018:3720684. Epub 2018 Dec 18.

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Homocysteine, a key component in one-carbon metabolism, is of great importance in remethylation. Many epidemiologic studies have assessed the association between homocysteine and risk of digestive tract cancer, but the results are inconsistent.

Objective: The objective of our meta-analysis is to assess the association between homocysteine and digestive tract cancer risk. Read More

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http://dx.doi.org/10.1155/2018/3720684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312580PMC
December 2018

The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma.

J Oncol 2018 18;2018:1953571. Epub 2018 Dec 18.

Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Republic of Korea.

Purpose: This study aimed to determine whether baseline blood inflammatory markers can predict progression-free survival (PFS) and overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC).

Methods: The study included 158 patients with mRCC treated with first-line targeted therapy between 2002 and 2016. A multivariable cox proportional hazards model identified inflammatory factors that predict PFS and OS. Read More

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http://dx.doi.org/10.1155/2018/1953571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312581PMC
December 2018
1 Read

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer.

J Oncol 2018 17;2018:2937012. Epub 2018 Dec 17.

Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.

The role of PD-L1 as a prognostic and predictive biomarker is an area of great interest. However, there is a lack of consensus on how to deliver PD-L1 as a clinical biomarker. At the heart of this conundrum is the subjective scoring of PD-L1 IHC in most studies to date. Read More

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http://dx.doi.org/10.1155/2018/2937012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311859PMC
December 2018
1 Read

Secretory High-Mobility Group Box 1 Protein Affects Regulatory T Cell Differentiation in Neuroblastoma Microenvironment .

J Oncol 2018 16;2018:7946021. Epub 2018 Dec 16.

Hematology and Oncology Division, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Neuroblastoma (NB) is the most common extracranial tumor of childhood with poor prognosis in a high-risk group. An obstacle in the development of treatment for solid tumors is the immunosuppressive nature of the tumor microenvironment (TME). Regulatory T cells (Tregs) represent a T cell subset with specialized function in immune suppression and maintaining self-tolerance. Read More

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http://dx.doi.org/10.1155/2018/7946021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311239PMC
December 2018
1 Read

Transforming of the Tumor Microenvironment: Implications for TGF- Inhibition in the Context of Immune-Checkpoint Therapy.

Authors:
Stefanie Löffek

J Oncol 2018 2;2018:9732939. Epub 2018 Dec 2.

Skin Cancer Unit of the Dermatology Department, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, and the German Cancer Consortium (DKTK), 45147 Essen, Germany.

Significant breakthroughs have been achieved in the fields of oncogenic signaling inhibition and particularly immune-checkpoint blockade has triggered substantial enthusiasm during the last decade. Antibody-mediated blockade of negative immune-checkpoint molecules (e.g. Read More

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https://www.hindawi.com/journals/jo/2018/9732939/
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http://dx.doi.org/10.1155/2018/9732939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304495PMC
December 2018
3 Reads

Quantitative Metastatic Lymph Node Regions on Magnetic Resonance Imaging Are Superior to AJCC N Classification for the Prognosis of Nasopharyngeal Carcinoma.

J Oncol 2018 2;2018:9172585. Epub 2018 Dec 2.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Purpose: Quantitative lymph node burden has been demonstrated to be a critical prognosticator in various malignancies, yet it was seldom explored in nasopharyngeal carcinoma (NPC). This study aimed to investigate the impact of the number of metastatic lymph node regions (LRN) on prognosis of NPC and to establish a new N classification system based on LRN.

Methods And Materials: The magnetic resonance images (MRI) of 354 nondisseminated NPC patients before radical treatment were retrospectively evaluated. Read More

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http://dx.doi.org/10.1155/2018/9172585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304546PMC
December 2018
1 Read

Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited.

J Oncol 2018 4;2018:6214838. Epub 2018 Dec 4.

Department of Surgery, University of Florida Health Sciences Center, Gainesville, FL 32610, USA.

Membrane transporters fulfill essential roles in maintaining normal cellular function in health. In cancer, transporters likewise facilitate the aberrant characteristics typical of proliferating tumor cells. Pancreatic ductal adenocarcinoma is remarkable in its aggressiveness, and its metabolism is supported by a variety of membrane transporters. Read More

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http://dx.doi.org/10.1155/2018/6214838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304534PMC
December 2018

Exploration of the Combination of PLK1 Inhibition with Immunotherapy in Cancer Treatment.

J Oncol 2018 2;2018:3979527. Epub 2018 Dec 2.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Background: PLK1 overexpression is oncogenic and is associated with poor prognosis in various cancers. However, the current PLK1 inhibitors have achieved limited clinical successes. On the other hand, although immunotherapies are demonstrating efficacy in treating many refractory cancers, a substantial number of patients do not respond to such therapies. Read More

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http://dx.doi.org/10.1155/2018/3979527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304487PMC
December 2018

Efficacy of Immunotherapy in Patients with Metastatic Mucosal or Uveal Melanoma.

J Oncol 2018 2;2018:1908065. Epub 2018 Dec 2.

Dermatology Department, Institute for Research and Innovation in Biomedicine, INSERM 1234, Rouen University Hospital, University of Normandie, Rouen, France.

Background: The objective was to assess the response rate and survival of patients with metastatic mucosal melanoma (MM) and uveal melanoma (UM) treated with anti-CTLA-4 or anti-PD-1 monoclonal antibodies (mAbs).

Methods: A multicenter retrospective study was performed in 25 dermatology departments in France. All patients with stage III-C to IV MM or UM who were treated with anti-CTLA-4 or anti-PD-1 mAbs between 2008 and 2016 were included and compared after adjustment for main prognostic factors with a second cohort of patients treated with chemotherapy. Read More

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https://www.hindawi.com/journals/jo/2018/1908065/
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http://dx.doi.org/10.1155/2018/1908065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304636PMC
December 2018
8 Reads

Resection of Liver Metastases: A Treatment Provides a Long-Term Survival Benefit for Patients with Advanced Pancreatic Neuroendocrine Tumors: .

J Oncol 2018 14;2018:6273947. Epub 2018 Nov 14.

Pancreatic Surgery Department, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.

Purpose: Nonsurgical therapies, including biotherapy, chemotherapy, and liver-directed therapy, provided a limit survival benefit for PNET patients with hepatic metastases. With the development of liver resection technique, there was a controversy on whether to perform a liver resection for these patients.

Methods: A computerized search was made of the Medline/PubMed, EMbase, Cochrane Library, and SinoMed (CBM) before March 2018. Read More

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http://dx.doi.org/10.1155/2018/6273947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261248PMC
November 2018
3 Reads

Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.

J Oncol 2018 8;2018:6301980. Epub 2018 Nov 8.

Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil.

Introduction: Differential expression of genes encoding cytochrome P450 (CYP) and other oxygenases enzymes involved in biotransformation mechanisms of endogenous and exogenous compounds can lead to oral tumor development.

Objective: We aimed to identify the expression profile of these genes, searching for susceptibility biomarkers in oral squamous cell carcinoma.

Patients And Methods: Sixteen oral squamous cell carcinoma samples were included in this study (eight tumor and eight adjacent non-tumor tissues). Read More

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https://www.hindawi.com/journals/jo/2018/6301980/
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http://dx.doi.org/10.1155/2018/6301980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250001PMC
November 2018
6 Reads

PPAR Enhances Cancer Cell Chemotherapy Sensitivity by Autophagy Induction.

J Oncol 2018 4;2018:6458537. Epub 2018 Nov 4.

Department of Oncology, The Affiliated Wujin People's hospital, Jiangsu University, Changzhou, Jiangsu Province, China.

PPAR (peroxisome-proliferator-activated receptor ) plays a critical role in regulation of inflammation and cancer, while the regulatory mechanism of PPAR on cancer cell autophagy is still unclear. Here we found that PPAR enhanced autophagy in HEK293T, SW480, and Hela cell lines, which was independent of PPAR transcription activity. PPAR induced antiapoptotic Bcl2 protein degradation resulting in release of the Beclin-1/VPS34 complex. Read More

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http://dx.doi.org/10.1155/2018/6458537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241347PMC
November 2018

Small or Non-Small Cell Lung Cancer Based Therapy for Treatment of Large Cell Neuroendocrine Cancer of The Lung? University of Cincinnati Experience.

J Oncol 2018 1;2018:9761826. Epub 2018 Nov 1.

Department of Hematology-Oncology, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Ave, Cincinnati, OH 45267, USA.

Large cell neuroendocrine cancer (LCNEC) of the lung exhibits morphological and immunohistochemical characteristics of both neuroendocrine and large cell carcinomas. No defined optimal therapy has been described for this subset of patients and the question of whether these patients should be treated with non-small cell lung cancer (NSCLC) treatment protocols, according to the National Comprehensive Cancer Network (NCCN) guidelines, or with small cell lung cancer (SCLC) due to histological and clinical similarities is still uncertain. We conducted a retrospective review of patients identified with diagnosis of LCNEC of the lung at the University of Cincinnati Cancer Center from the year 2002 to 2012 to determine which treatment approach resulted in improved outcomes in this rare category of disease. Read More

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https://www.hindawi.com/journals/jo/2018/9761826/
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http://dx.doi.org/10.1155/2018/9761826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236557PMC
November 2018
2 Reads

Risk Factors for Fatal Pulmonary Hemorrhage following Concurrent Chemoradiotherapy in Stage 3B/C Squamous-Cell Lung Carcinoma Patients.

J Oncol 2018 1;2018:4518935. Epub 2018 Nov 1.

Bahcesehir University Medical Faculty, Department of Radiation Oncology, Istanbul, Turkey.

We aimed to identify the fatal pulmonary hemorrhage- (FPH-) related risk factors in stage 3B/C squamous-cell lung carcinoma (SqCLC) patients treated with definitive concurrent chemoradiotherapy (C-CRT). Medical records of 505 stage 3B/C SqCLC patients who underwent 66 Gy radiotherapy plus 1-3 cycles of concurrent chemotherapy with available pretreatment thoracic computerized tomography scans were retrospectively analyzed. Primary end-point was the identification of FPH-related risk factors. Read More

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http://dx.doi.org/10.1155/2018/4518935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236701PMC
November 2018

Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy.

J Oncol 2018 25;2018:8653489. Epub 2018 Oct 25.

Division of Clinical Physiology and Therapeutics, Keio University, Faculty of Pharmacy, 1-5-30, Shiabakoen, Minato-Ku, Tokyo, Japan.

Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or adoptive T cell therapies, have contributed to better outcomes in cancer patients. However, there are still many cancers with no cure. Therefore, combinations of several treatment strategies are being explored, and enhancing anticancer immunity will play an important role to combat the disease. Read More

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http://dx.doi.org/10.1155/2018/8653489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222238PMC
October 2018

Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer.

J Oncol 2018 16;2018:3812581. Epub 2018 Oct 16.

Department of System Biology, Unit of Biochemistry and Molecular Biology, University of Alcalá, Alcalá de Henares, Spain.

We reported that insulin receptor substrate 4 (IRS-4) levels increased in tissue from colorectal cancer (CRC) patients and promoted retinoblastoma-cyclin-dependent kinase activation. The aim of the present study was to evaluate the effect of IRS-4 on IGF-1 receptor pathway and its impact on procaspase 3 and PARP expression in RKO and HepG2 cancer cell lines. The results obtained were compared with those obtained from biopsies of patients with CRC (n = 18), tubulovillous adenomas (TA) (n = 2) and in matched adjacent normal colorectal (MANC) tissue (n = 20). Read More

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https://www.hindawi.com/journals/jo/2018/3812581/
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http://dx.doi.org/10.1155/2018/3812581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206579PMC
October 2018
8 Reads

Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA.

J Oncol 2018 11;2018:2183179. Epub 2018 Oct 11.

Department of Emergency Medicine, Inha University School of Medicine, Incheon, Republic of Korea.

Background/aims: Febrile neutropenia is considered as one of the most important and potentially life-threatening oncologic emergencies, which requires prompt medical assessment and treatment with antibiotics. This was a single-center retrospective study that investigated the prognostic factors predicting poor outcome in patients with cancer who presented with febrile neutropenia at the emergency department (ED).

Methods: The medical records of patients diagnosed with febrile neutropenia in the ED from January 2014 to December 2017 were reviewed. Read More

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https://www.hindawi.com/journals/jo/2018/2183179/
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http://dx.doi.org/10.1155/2018/2183179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201329PMC
October 2018
7 Reads

Treatment-Related Adverse Effects in Lung Cancer Patients after Stereotactic Ablative Radiation Therapy.

J Oncol 2018 4;2018:6483626. Epub 2018 Oct 4.

Cancer Research Institute and School of Health Sciences, University of South Australia, Adelaide SA 5001, Australia.

Introduction: Lung cancer is a disease which, despite the advancements in treatment, still has a very poor 5-year survival rate. Stereotactic ablative radiation therapy (SABR) is a highly advanced, sophisticated, and safe treatment which allows patients with early stage lung cancer to be treated effectively without invasive procedures and with excellent clinical outcomes. Avoiding surgery minimises morbidity and recovery time, bettering patients' quality of life. Read More

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http://dx.doi.org/10.1155/2018/6483626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193322PMC
October 2018
2 Reads

Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer.

J Oncol 2018 1;2018:3725837. Epub 2018 Oct 1.

Division of Radiation Oncology, Regional Cancer Centre, Trivandrum, India.

Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. Read More

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https://www.hindawi.com/journals/jo/2018/3725837/
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http://dx.doi.org/10.1155/2018/3725837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188855PMC
October 2018
7 Reads

Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis.

J Oncol 2018 26;2018:3098940. Epub 2018 Sep 26.

Department of Dermatovenereology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia.

Background: BCC is currently the most common type of skin cancer in humans. Although having a low-grade malignancy and metastatic potential, BCC is locally aggressive and destructive. Despite numerous studies, the origin of BCC, whether arising from the follicular or interfollicular layer, remains controversial. Read More

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http://dx.doi.org/10.1155/2018/3098940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178174PMC
September 2018
2 Reads

HBV-DNA Load-Related Peritumoral Inflammation and ALBI Scores Predict HBV Associated Hepatocellular Carcinoma Prognosis after Curative Resection.

J Oncol 2018 20;2018:9289421. Epub 2018 Sep 20.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Background: Both persistent inflammatory activity and liver function damage contribute to a poor prognosis of hepatocellular carcinoma (HCC). This study aimed to develop nomograms that incorporate hepatitis virus B (HBV)-related peritumoral inflammation score (PIS) and liver function based on ALBI score to predict postoperative outcomes of HCC.

Methods: The prognostic roles of HBV-related preoperative PIS and ALBI scores in HCC recurrence were examined, and then two nomograms were constructed. Read More

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http://dx.doi.org/10.1155/2018/9289421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171205PMC
September 2018
3 Reads

Additional Biomarkers beyond RAS That Impact the Efficacy of Cetuximab plus Chemotherapy in mCRC: A Retrospective Biomarker Analysis.

J Oncol 2018 16;2018:5072987. Epub 2018 Sep 16.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Purpose: We aimed to identify new predictive biomarkers for cetuximab in first-line treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC).

Methods: The study included patients with KRAS wild-type unresectable liver-limited mCRC treated with chemotherapy with or without cetuximab. Next-generation sequencing was done for single nucleotide polymorphism according to custom panel. Read More

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https://www.hindawi.com/journals/jo/2018/5072987/
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http://dx.doi.org/10.1155/2018/5072987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165607PMC
September 2018
4 Reads

Outcomes Following Salvage Radiation and Systemic Therapy for Isolated Locoregional Recurrence of Breast Cancer after Mastectomy: Impact of Constructed Biologic Subtype.

J Oncol 2018 12;2018:4736263. Epub 2018 Sep 12.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: This study examines factors associated with outcomes following salvage radiation and systemic therapy for breast cancer patients who developed isolated locoregional recurrence (ILRR) after mastectomy alone, while focusing on the prognostic significance of constructed biologic subtype in this setting.

Methods And Materials: 269 postmastectomy patients in total treated for ILRR were included. Cumulative incidence of locoregional control (LRC), distant metastasis (DM)-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were calculated using Kaplan-Meier method. Read More

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http://dx.doi.org/10.1155/2018/4736263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157175PMC
September 2018
4 Reads

The Utility of Preoperative Vascular Grading in Patients Undergoing Surgery First for Pancreatic Cancer: Does Radiologic Arterial or Venous Involvement Predict Pathologic Margin Status?

J Oncol 2018 13;2018:7675262. Epub 2018 Aug 13.

Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

Controversy exists on accurately grading vascular involvement on preoperative imaging for pancreatic ductal adenocarcinoma. We reviewed the association between preoperative imaging and margin status in 137 patients. Radiologists graded venous involvement based on the Ishikawa classification system and arterial involvement based on preoperative imaging. Read More

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http://dx.doi.org/10.1155/2018/7675262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110012PMC

Correlation between Psychosocial Distress and Quality of Life in Patients with Nasopharyngeal Carcinoma following Radiotherapy.

J Oncol 2018 6;2018:3625302. Epub 2018 Aug 6.

Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei, Anhui 230601, China.

The aim of this study was to investigate the relationship between psychosocial distress and quality of life (QOL) in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Fifty-three patients with an initial diagnosis of NPC were enrolled in this study. The psychological Distress Thermometer (DT) and Functional Assessment of Cancer Therapy-Head & Neck (FACT-H&N) were conducted before and after radiotherapy in NPC patients. Read More

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http://dx.doi.org/10.1155/2018/3625302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106906PMC
August 2018
7 Reads

MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer.

J Oncol 2018 6;2018:5167829. Epub 2018 Aug 6.

Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.

MicroRNAs (miRNAs) are small, highly conserved noncoding RNAs molecules, consisting of 18-25 nucleotides that regulate gene expression by binding to complementary binding sites within the 3'untranslated region (3'UTR) of target mRNAs. MiRNAs have been involved in regulating gene expression and diverse physiological and pathological processes. Several studies have reported that miR-30a, situated on chromosome 6q. Read More

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http://dx.doi.org/10.1155/2018/5167829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106977PMC
August 2018
10 Reads

A Machine Learning Approach for the Association of ki-67 Scoring with Prognostic Factors.

Authors:
E Dirican E Kiliç

J Oncol 2018 7;2018:1912438. Epub 2018 Aug 7.

General Surgery, Faculty of Medicine, Mustafa Kemal University, Hatay 31000, Turkey.

ki-67 score is a solid tumor proliferation marker being associated with the prognosis of breast carcinoma and its response to neoadjuvant chemotherapy. In the present study, we aimed to investigate the way of clustering of prognostic factors by ki-67 score using a machine learning approach and multiple correspondence analysis. In this study, 223 patients with breast carcinoma were analyzed using the random forest method for classification of prognostic factors according to ki-67 groups (<14% and >14%). Read More

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https://www.hindawi.com/journals/jo/2018/1912438/
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http://dx.doi.org/10.1155/2018/1912438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106968PMC
August 2018
9 Reads

The Association of Simultaneous Increase in Interleukin-6, C Reactive Protein, and Matrix Metalloproteinase-9 Serum Levels with Increasing Stages of Colorectal Cancer.

J Oncol 2018 30;2018:2830503. Epub 2018 Jul 30.

Department of Pathology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Background: Tumor development and growth are driven in many cases by inflammatory cells, which can produce cytokines and other factors that can stimulate the development of the malignant process. The aim of this study was to evaluate interleukin-6 (IL-6), C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9), serum levels in patients with colorectal cancer (CRC), and their association with the stage of CRC.

Methods: IL-6, MMP-9, and CRP serum levels were measured in 75 patients with CRC just before surgical treatment, as well as in 20 healthy individuals as controls. Read More

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http://dx.doi.org/10.1155/2018/2830503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091449PMC

Clinical and Molecular Characteristics Associated with Survival in Advanced Melanoma Treated with Checkpoint Inhibitors.

J Oncol 2018 17;2018:6279871. Epub 2018 Jul 17.

Hurley Medical Center/Michigan State University, 1 Hurley Plaza, Flint, Michigan 48503, USA.

Background: We performed meta-analysis to gather more evidence regarding clinical-molecular subgroups associated with better overall survival (OS) in advanced melanoma treated with checkpoint inhibitors.

Materials And Methods: We performed a systematic search of PubMed, Scopus, Cochrane Library, and clinical trial.gov. Read More

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http://dx.doi.org/10.1155/2018/6279871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077519PMC
July 2018
1 Read

Inhibition of MDM2 via Nutlin-3A: A Potential Therapeutic Approach for Pleural Mesotheliomas with MDM2-Induced Inactivation of Wild-Type P53.

J Oncol 2018 17;2018:1986982. Epub 2018 Jul 17.

Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Previously, our group demonstrated that nuclear expression of E3 ubiquitin ligase (MDM2) in malignant pleural mesothelioma (MPM) is significantly associated with decreased overall survival. A possible explanation may be that overexpression of MDM2 leads to a proteasomal degradation of TP53 that eventually results in a loss of TP53-induced apoptosis and senescence. It is well known from other tumor entities that restoration of TP53 activity, e. Read More

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https://www.hindawi.com/journals/jo/2018/1986982/
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http://dx.doi.org/10.1155/2018/1986982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077509PMC
July 2018
17 Reads

S100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer.

J Oncol 2018 9;2018:1828791. Epub 2018 Jul 9.

Department of General Surgery, Gulhane Education and Research Hospital, Ankara, Turkey.

Background: Globally, the colorectal cancers rank the third in terms of cancer incidence and rank the fourth in cancer-associated deaths. S100A4, an important member of the S100 protein family, serves to promote tumor progression and metastasis. By conducting this study, we aim to examine the role of S100A4 in the prognosis of colon cancer and to demonstrate its prognostic significance. Read More

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http://dx.doi.org/10.1155/2018/1828791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077577PMC
July 2018
36 Reads

Research Priorities and Resource Allocation in the Investigation of New Drugs for Cancer in Least Developed Countries.

J Oncol 2018 2;2018:8092702. Epub 2018 Jul 2.

Faculty of Health Sciences, University of Brasilia (UnB), Campus Universitário Darcy Ribeiro, 70910-900 Brasília, Brazil.

Cancer incidence has increased significantly in low- and middle-income countries. The priorities of international health research are not always aligned with the global burden of cancer. This study aims to analyze global tendencies in clinical trials in oncology and discuss research priorities and resource allocation in the investigation of new drugs for cancers that significantly affect the least developed countries. Read More

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http://dx.doi.org/10.1155/2018/8092702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051037PMC
July 2018
16 Reads

The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review.

J Oncol 2018 2;2018:1236787. Epub 2018 Jul 2.

Mental Health and Wellbeing Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Jette, Brussels, Belgium.

This article reviews the role of the vagus nerve in tumor modulation and cancer prognosis. We present a systematic review of 12 epidemiological studies examining the relationship between heart rate variability, the main vagus nerve index, and prognosis in cancer patients (survival and tumor markers). These studies show that initially high vagal nerve activity predicts better cancer prognosis, and, in some studies, independent of confounders such as cancer stage and treatments. Read More

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http://dx.doi.org/10.1155/2018/1236787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051067PMC
July 2018
18 Reads

Survival Outcomes and Factors Associated with Revision Surgery for Metastatic Disease of the Spine.

J Oncol 2018 25;2018:6140381. Epub 2018 Jun 25.

Department of Orthopaedic Surgery, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.

Study Design: Retrospective review of a prospective database.

Objective: Certain subset of patients undergoing surgical treatment for spinal metastasis will require a revision surgery in their disease course; however, factors predictive of revision surgery and survival outcomes are largely unknown. The goal of this study is to report on survival outcomes as well as factors predictive of revision surgery in this unique patient population. Read More

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http://dx.doi.org/10.1155/2018/6140381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036797PMC

Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru.

J Oncol 2018 19;2018:3924635. Epub 2018 Jun 19.

Pediatric Oncology Unit, Edgardo Rebagliati Martins Hospital, 490 Domingo Cueto Avenue, Lima 11, Peru.

Background: The causes of childhood cancer are not well known, but the advanced age of the parents has been suggested as a risk factor for childhood cancer in several observational studies. In this study, we examine a possible link between parental age and childhood solid tumors.

Methods: We conducted a hospital-based case-control study (310 cases and 620 controls, matched by age and gender) at Rebagliati Hospital, Lima, Peru. Read More

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http://dx.doi.org/10.1155/2018/3924635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029448PMC
June 2018
1 Read

and mRNAs Are Higher in Blood from Breast Cancer Patients with Metastatic Disease than Those without.

J Oncol 2018 7;2018:4793498. Epub 2018 Jun 7.

Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Egypt.

Introduction: Breast cancer metastasis occurs when tumor cells dissociate from the primary tumor and migrate to distant organs through the peripheral bloodstream or lymphatic drainage. Circulating tumor cells (CTCs) originate from primary sites or metastases and circulate in the patients' bloodstream. Molecular assays for the detection and molecular characterization of CTCs can serve as a liquid biopsy and can represent an alternative to invasive biopsies as a source of tumor tissue in the metastatic patients. Read More

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http://dx.doi.org/10.1155/2018/4793498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011051PMC
June 2018
15 Reads

Epimutation and Cancer: Carcinogenesis Viewed as Error-Prone Inheritance of Epigenetic Information.

Authors:
Patrick A Riley

J Oncol 2018 3;2018:2645095. Epub 2018 Jun 3.

Totteridge Institute for Advanced Studies, The Grange, Grange Avenue, London N20 8AB, UK.

The epimutation concept, that is, malignancy is a result of deranged patterns of gene expression due to defective epigenetic control, proposes that in the majority of adult cancers the primary (initiating) lesion adversely affects the mechanism of vertical transmission of the epigenetic pattern existing in the stem cells of differentiated tissue. Such an error-prone mechanism will result in deviant gene expression capable of accumulation at each mitosis of the affected stem cell clone. It is argued that a proportion of these proliferation products will express combinations of genes which endow them with malignant properties, such as the ability to transgress tissue boundaries and migrate to distant locations. Read More

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http://dx.doi.org/10.1155/2018/2645095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008765PMC

Complex Karyotype in Hematological Diseases: A 6-Year Single Centre Study from Pakistan.

J Oncol 2018 3;2018:2019239. Epub 2018 Jun 3.

National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, Pakistan.

Background: Most of the hematological disorders are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements. Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients. Though rarer, complex karyotype has been associated with worst prognosis. Read More

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http://dx.doi.org/10.1155/2018/2019239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008829PMC
June 2018
20 Reads

Multifactorial Analysis of Mortality in Screening Detected Lung Cancer.

J Oncol 2018 16;2018:1296246. Epub 2018 May 16.

Division of Thoracic Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

We hypothesized that severity of coronary artery calcification (CAC), emphysema, muscle mass, and fat attenuation can help predict mortality in patients with lung cancer participating in the National Lung Screening Trial (NLST). Following regulatory approval from the Cancer Data Access System (CDAS), all patients diagnosed with lung cancer at the time of the screening study were identified. These subjects were classified into two groups: survivors and nonsurvivors at the conclusion of the NLST trial. Read More

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http://dx.doi.org/10.1155/2018/1296246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976935PMC
May 2018
5 Reads

The Plasticity of CD4CD25FOXP3CD127 T Cells in Patients with Metastatic Renal Cell Carcinoma in the Course of Interferon-Alpha Immunotherapy.

J Oncol 2018 2;2018:7828735. Epub 2018 May 2.

Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Moscow 117997, Russia.

Aims: To examine changes in subpopulation of CD4CD25Foxp3CD127 T lymphocytes (Treg) and their association with the efficiency of the IFN- therapy.

Materials And Methods: Pts with mRCC who had undergone nephrectomy were treated with IFN- at a dose of 6 × 10 U/day three times a week ( = 18). An immunophenotypic analysis of lymphocytes in peripheral blood expressing CD4, CD25, CD127, and Foxp3 antigens could be performed in 18 pts before, 2 weeks, and 2 mo after IFN- therapy and 22 normal volunteers. Read More

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http://dx.doi.org/10.1155/2018/7828735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954933PMC
May 2018
7 Reads

Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary.

J Oncol 2018 7;2018:3519247. Epub 2018 May 7.

Division of Medical Oncology, University of Kentucky, Lexington, KY, USA.

Incidence of low grade well-differentiated neuroendocrine tumors (NET) is on the rise. The North American Neuroendocrine Tumor Society estimates that the United States has more than 150,000 gastroenteropancreatic NET patients. About 10% of metastatic NETs can be unknown primary, and due to their rarity, dedicated treatment algorithms and regimens are not defined. Read More

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https://www.hindawi.com/journals/jo/2018/3519247/
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http://dx.doi.org/10.1155/2018/3519247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964580PMC
May 2018
2 Reads