27,549,790 results match your criteria Journal of Occupational Medicine and Toxicology JOMT [Journal]

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Suppressor of Variegation 3-9 Homolog 2, a Novel Binding Protein of Translationally Controlled Tumor Protein, Regulates Cancer Cell Proliferation.

Biomol Ther (Seoul) 2019 Feb 15. Epub 2019 Feb 15.

Division of Translational Science, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.

Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) methylates the lysine 9 residue of histone H3 and induces heterochromatin formation, resulting in transcriptional repression or silencing of target genes. SUV39H1 and SUV39H2 have a role in embryonic development, and SUV39H1 was shown to suppress cell cycle progression associated with Rb. However, the function of human SUV39H2 has not been extensively studied. Read More

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http://dx.doi.org/10.4062/biomolther.2019.021DOI Listing
February 2019

Development of genetic evaluation for milk production traits of Holsteins in Japan.

Authors:
Koichi Hagiya

Anim Sci J 2019 Feb 14. Epub 2019 Feb 14.

Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.

The procedure used for the genetic evaluation of dairy cattle in Japan has developed from a lactation sire-MGS model to a multiple-lactation random regression test-day animal model. Genetic evaluation of Holstein bulls in Japan began in 1989 with the use of field-style progeny testing; dairy herd improvement program data from all over Japan were used, along with a sire and maternal grandsire model. In 1993, an animal model was introduced to estimate breeding values for yield and type traits. Read More

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http://dx.doi.org/10.1111/asj.13190DOI Listing
February 2019
1 Read

Urine metabolic profiles in paediatric asthma.

Respirology 2019 Feb 14. Epub 2019 Feb 14.

Department of Paediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Background And Objective: Asthma is a global problem and complex disease suited for metabolomic profiling. This study explored the candidate biomarkers specific to paediatric asthma and provided insights into asthmatic pathophysiology.

Methods: Children (aged 6-11 years) meeting the criteria for healthy control (n = 29), uncontrolled asthma (n = 37) or controlled asthma (n = 43) were enrolled. Read More

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http://dx.doi.org/10.1111/resp.13479DOI Listing
February 2019

Gut microbiota diversity associates with cardiorespiratory fitness in post-primary treatment breast cancer survivors.

Exp Physiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Nutrition Sciences, University of Alabama at Birmingham.

New Findings: What is the central question of this study? Does the link between cardiorespiratory fitness and gut microbiota diversity persist after adjusting for the potential effects of %body fat and activity-related energy expenditure (AEE)? What is the main finding and its importance? This is the first study to examine the link between cardiorespiratory fitness and gut microbiota diversity while accounting for the underlying effects of %body fat and free-living AEE. Results from the present work suggest cardiorespiratory fitness, not physical activity, is a superior correlate of gut microbiota diversity among post-primary treatment, non-metastatic breast cancer survivors.

Abstract: Cancer treatment uniquely triggers multiple physiologic shifts detrimental to overall health. Read More

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http://dx.doi.org/10.1113/EP087404DOI Listing
February 2019

Predicting the cytotoxicity of chemicals using ensemble learning methods and molecular fingerprints.

J Appl Toxicol 2019 Feb 14. Epub 2019 Feb 14.

School of Life Science, Liaoning University, Shenyang, 110036, China.

The prediction of compound cytotoxicity is an important part of the drug discovery process. However, it usually appears as poor predictive performance because the datasets are high-throughput and have a class-imbalance problem. In this study, several strategies of performing a structure-activity relationship study for a cytotoxic endpoint in the AID364 dataset were explored to solve the class-imbalance problem. Read More

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http://dx.doi.org/10.1002/jat.3785DOI Listing
February 2019

In vitro genotoxicity assessment of nickel(II) oxide nanoparticles on lymphocytes of human peripheral blood.

J Appl Toxicol 2019 Feb 14. Epub 2019 Feb 14.

Toxicology Lab, Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.

The current study was intended to elucidate the cytotoxicity, genotoxicity ability of nickel oxide (NiO) nanoparticles (NPs) and assessment of preliminary mechanism of the toxicity. Characterization studies showed that NiO-NPs have a particle size of 17.94 (±3. Read More

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http://doi.wiley.com/10.1002/jat.3784
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http://dx.doi.org/10.1002/jat.3784DOI Listing
February 2019
4 Reads

Sports-Related Concussion: Neurometabolic Aspects.

Semin Speech Lang 2019 Feb 14. Epub 2019 Feb 14.

Clinical Laboratory Sciences/MPH Programs, The University of Texas at El Paso, El Paso, Texas.

Concussion is a transitory brain injury resulting from a blow to the head. Concussion is considered a mild traumatic brain injury (mTBI), which is self-limited. Repetitive mTBI has been associated with chronic, progressive neurological damage. Read More

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http://dx.doi.org/10.1055/s-0039-1679887DOI Listing
February 2019

[Antibiotic treatment of infections in burn patients - a systematic review].

Handchir Mikrochir Plast Chir 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum, Operatives Referenzzentrum für Gliedmaßentumore, BG Universitätskliniken Bergmannsheil.

Background: Due to the loss of the natural skin barrier function with reduced immune competence as a result of a plasma loss and the numerous intensive care interventions, burn patients are particularly at risk for infection.

Study Design: systematic review METHODS: A systematic review of German and English literature between 1990 and 2018 analyzes the epidemiological and diagnostic aspects as well as the therapeutic use of antibiotics in infections of burn patients in clinical trials.

Results: A total number of 53 randomized controlled clinical trials met the inclusion criteria. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0802-8882
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http://dx.doi.org/10.1055/a-0802-8882DOI Listing
February 2019
1 Read

Prof. Heinz Bohmert.

Authors:

Handchir Mikrochir Plast Chir 2019 Feb 14. Epub 2019 Feb 14.

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http://dx.doi.org/10.1055/a-0815-7947DOI Listing
February 2019

[Psychosomatic urology: how to treat chronic urological diseases].

Aktuelle Urol 2019 Feb 14. Epub 2019 Feb 14.

Ambulantes Rehabilitations-Zentrum für Urologie und Gynäkologie Heidelberg, Facharztpraxis für Urologie, Heidelberg.

In specialist urology clinics, 50 - 70 % of patients have chronic urological diseases such as recurrent urinary tract infections, a somatoform overactive bladder, adult and infantile enuresis, a chronic pelvic pain syndrome, and the psychosomatic form of post-prostatectomy incontinence. The 12-month prevalence of psychological disorders in the general adult population is 28 % 1. As many as 20 % of children and adolescents are found to have psychological abnormalities 2. Read More

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http://dx.doi.org/10.1055/a-0834-5989DOI Listing
February 2019

[Involvement of an extralymphatic organ in Hodgkin's lymphoma].

Authors:
Pierre Einwaller

Aktuelle Urol 2019 Feb 14. Epub 2019 Feb 14.

Alexianer Krefeld GmbH, Klinik für Urologie und Kinderurologie, Krefeld.

This case report describes the rare entity of Hodgkin's lymphoma manifesting itself in an extralymphatic organ. To rule out a second malignancy, we performed a transurethral resection of the urinary bladder (TUR-B) in our urology department, confirming the histological findings. After that, the patient received oncological treatment based on the current guidelines. Read More

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http://dx.doi.org/10.1055/a-0834-6027DOI Listing
February 2019

[Optic Disc Changes in Childhood].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):203-218. Epub 2019 Feb 14.

The ophthalmological inspection of the optic disc is possible since the time of birth. Thereby, changes of normal optic disc configuration can already be detected in early infancy. Congenital optic disc anomalies can go along with congenital malformations of the brain or with syndromal systemic diseases. Read More

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http://dx.doi.org/10.1055/a-0818-1790DOI Listing
February 2019

[Emotional and Psychological Peculiarities in Glaucoma].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):154-157. Epub 2019 Feb 14.

Augenärztin, Praxis an der Lichtwiese, Darmstadt.

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http://dx.doi.org/10.1055/a-0834-6093DOI Listing
February 2019

[Glaucoma-Related Sleep Disorder and Associated Diseases].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):150-153. Epub 2019 Feb 14.

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Hamburg-Eppendorf.

The simultaneous occurrence of sleeping disorders and glaucoma is caused by multiple factors and, until today, the underlying mechanisms are not completely understood. There seems to be correlations, either between sleeping disorders in patients with a diagnosed glaucoma and between the onset of a glaucoma in patients with certain sleeping habits, but no precise data has been collected so far. Read More

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http://dx.doi.org/10.1055/a-0809-5735DOI Listing
February 2019

[Neuronal Blood Pressure Regulation].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):145-149. Epub 2019 Feb 14.

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln.

Neuronal blood pressure control is mediated by the autonomic nervous system. In this article, physiological and pathophysiological mechanisms will be recapitulated. Blood pressure regulation aims at maintaining adequate cardiac output and a sufficient perfusion pressure for the organs. Read More

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http://dx.doi.org/10.1055/a-0808-4843DOI Listing
February 2019

[The Importance of the Lymphatic and the Glymphatic System for Glaucoma].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):142-144. Epub 2019 Feb 14.

Augenklinik, Kantonsspital Aarau, Schweiz.

Normal tension glaucoma is a variant of primary open angle glaucoma. It is characterized by normal intraocular pressure. Although there are several pathophysiological explanations (e. Read More

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http://dx.doi.org/10.1055/a-0809-5692DOI Listing
February 2019

[Impairment of the Visual System in Glaucoma].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):134-141. Epub 2019 Feb 14.

Interdisziplinäres Zentrum für Präventive Augenheilkunde und Imaging, Augenklinik, Universitätsklinikum Erlangen.

MR Diffusion Tensor Imaging (DTI) enables visualisation of the visual system in glaucoma; it has been shown that the atrophy of the optic radiation is more pronounced in glaucoma than in age-matched controls. The atrophy of the optic radiation thereby correlates with OCT and visual field measures. Diffusion tensor imaging permits quantification of the axonal integrity of the optic radiation by calculation of fractional anisotropy (FA) and radial diffusivity (RD). Read More

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http://dx.doi.org/10.1055/a-0762-0822DOI Listing
February 2019

[Neurological Aspects of Glaucoma].

Authors:
Carl Erb

Klin Monbl Augenheilkd 2019 Feb 14;236(2):132-133. Epub 2019 Feb 14.

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http://dx.doi.org/10.1055/a-0818-1764DOI Listing
February 2019

Erratum to: Machine Learning and Data Analytics in Pervasive Health.

Methods Inf Med 2019 Feb 14. Epub 2019 Feb 14.

Peter L. Reichertz Institute for Medical Informatics of University of Braunschweig - Institute of Technology and Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1055/s-0039-1677748DOI Listing
February 2019

Diagnosing Immune Thrombocytopenia.

Authors:
Ulrich J Sachs

Hamostaseologie 2019 Feb 14. Epub 2019 Feb 14.

Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany.

Although the detection of a characteristic autoantibody can prove immune thrombocytopenia (ITP), this diagnosis is often based on the exclusion of other causes of thrombocytopenia. Direct glycoprotein (GP)-specific tests have the property required to demonstrate such a characteristic autoantibody. In contrast, platelet-associated immunoglobulin G or antibody detection in plasma or serum is an insufficient diagnostic test. Read More

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http://dx.doi.org/10.1055/s-0039-1678739DOI Listing
February 2019

Evidence of Pituitary Tumor and Acromegaly in an Ancient Egyptian Mummy Head.

Rofo 2019 Feb 14. Epub 2019 Feb 14.

Reiss-Engelhorn-Museen Mannheim, German Mummy Project, Mannheim, Germany.

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http://dx.doi.org/10.1055/a-0851-6798DOI Listing
February 2019

Health Technology Assessments in Radiology in Germany: Lack of Demand, Lack of Supply.

Rofo 2019 Feb 14. Epub 2019 Feb 14.

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.

Background:  Health technology assessments (HTAs) are an interdisciplinary method to support sustainable, evidence-based healthcare decisions. They systematically assess medical products, procedures, and technologies with respect to medical, economic, legal, social, and ethical aspects.

Method:  This review analyzes the current use of HTAs in radiology in Germany and discusses challenges associated with HTAs. Read More

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http://dx.doi.org/10.1055/a-0838-6253DOI Listing
February 2019

[Calcified Cysticercosis and Differential Diagnosis of Intracranial, Cutaneous and Subcutanoeus Calcifications.]

Rofo 2019 Feb 14. Epub 2019 Feb 14.

Department for Diagnostic and Interventional Radiology, University-Hospital Tübingen.

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http://dx.doi.org/10.1055/a-0846-7527DOI Listing
February 2019

[The CIMH Track Concept in Psychiatry: Syndrome-specific Treatment across Modalities - Part 1 - Theoretical background].

Fortschr Neurol Psychiatr 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Psychiatrie und Psychotherapie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland.

During the past decades, important progress was made in the treatment of patients with mental disorders. Nevertheless, the guideline-based treatment still represents a significant challenge that must take into account novel diagnostic and therapeutic possibilities as well as recent social development and the economic framework. Therefore, there is a need for further improvement of care in inpatient, day-care and outpatient hospital units. Read More

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http://dx.doi.org/10.1055/a-0759-1859DOI Listing
February 2019

[Diagnostic Strategy and Therapeutic Dilemma in Acute Posterior and Panuveitis].

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Augenklinik, Universitätsspital Basel, Schweiz.

Acute posterior and panuveitis mostly affect younger patients and affect both eyes in more than half of cases. Because of the severe consequences in the clinical course, rapid and broad differential diagnosis are critical steps. Permanent loss of vision after a delay in starting therapy and the initiation of ineffective treatment are both serious risks. Read More

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http://dx.doi.org/10.1055/a-0828-7395DOI Listing
February 2019

[Ocular Phenotype and Complications in Patients with Tuberous Sclerosis Complex (TSC)].

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Augenklinik, UniversitätsSpital Zürich, Schweiz.

Background: Evaluation and comparison of the ocular phenotype in patients diagnosed with tuberous sclerosis complex (TSC). Analysis of ocular complications during follow-up.

Patients And Methods: A retrospective chart review was performed of patients with TSC who had received an ocular examination at the eye clinic of the University Hospital Zurich. Read More

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http://dx.doi.org/10.1055/a-0804-1816DOI Listing
February 2019

The Heimann-Bielschowsky Phenomenon: A Retrospective Case Series and Literature Review.

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland.

Background: The Heimann-Bielschowsky phenomenon (HBP) is an unusual form of monocular vertical pendular nystagmus and is usually asymptomatic. It always occurs in an eye with longstanding, profound visual loss. Reports of HBP are few and HBP is probably underdiagnosed. Read More

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http://dx.doi.org/10.1055/a-0829-6001DOI Listing
February 2019

[Prophylaxis of Recurrent Cytomegalovirus Uveitis with Topical Ganciclovir].

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: Cytomegalovirus (CMV) can cause recurrent or chronic hypertensive anterior uveitis in immunocompetent patients. Antiviral treatment options include topical ganciclovir or systemic valganciclovir. However, recurrences are common after stopping treatment. Read More

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http://dx.doi.org/10.1055/a-0816-5598DOI Listing
February 2019

Visual Performance, Subjective Satisfaction and Quality of Life Effect of a New Refractive Intraocular Lens with Central Extended Depth of Focus.

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Glaucoma Research Centre, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland.

Purpose: To assess the visual performance, clinical and quality of life outcomes, and subjective patient satisfaction after implantation of a new refractive/extended depth of focus (EDOF) hybrid intraocular lens (IOL).

Methods: This is a monocentric, retrospective study of 29 patients (45 eyes), carried out in a tertiary care glaucoma research centre. All patients underwent implantation of a Lucidis (Swiss Advanced Vision, SAV-IOL SA, Neuchâtel, Switzerland) IOL during cataract surgery. Read More

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http://dx.doi.org/10.1055/a-0799-9700DOI Listing
February 2019

Pseudouveitis and Iris Atrophy in Pigment Dispersion Syndrome after Sulcus Implantation of a One-Piece IOL with Square Edge Haptics (SN6AT6).

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Uveitis and Inflammation, Hopital Ophtalmique Jules Gonin, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1055/a-0829-6121DOI Listing
February 2019

The Posterolateral Corner-Locked Technique Is Applicable in a Chinese Population Regarding the Tibial Component Rotation Alignment in Total Knee Arthroplasty.

J Knee Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Orthopaedic Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.

Rotational malalignment between the femoral and tibial components in total knee arthroplasty (TKA) can affect clinical outcomes, but there is no consensus on how to best determine tibia tray orientation. The posterolateral corner-locked (PLCL) technique may be a new method. This study aims to assess the applicability of this technique in a Chinese population. Read More

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http://dx.doi.org/10.1055/s-0039-1678536DOI Listing
February 2019

[Lobectomy of Right Lower Lobe Eight Years after Foreign Body Aspiration].

Pneumologie 2019 Feb 14. Epub 2019 Feb 14.

Thoraxzentrum Ruhrgebiet, Klinik für Thoraxchirurgie, Evangelisches Krankenhaus, Herne.

A young man presented with haemoptysis, eight years after foreign body aspiration. The initial evaluation took place in the emergency department of a general hospital. However, neither chest x-ray nor bronchoscopy were performed. Read More

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http://dx.doi.org/10.1055/a-0830-1524DOI Listing
February 2019

Teaching Endocrinology-The Highest Calling.

Endocrinology 2019 Mar;160(3):534-535

Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1210/en.2019-00082DOI Listing

Circadian phenotype impacts the brain's resting state functional connectivity, attentional performance and sleepiness.

Sleep 2019 Feb 15. Epub 2019 Feb 15.

Centre for Human Brain Health, University of Birmingham, Birmingham, UK.

Introduction: Functional connectivity (FC) of the human brain's intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.

Study Objectives: The aim of this study was to investigate resting state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day. Read More

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http://dx.doi.org/10.1093/sleep/zsz033DOI Listing
February 2019

Family reflections: prematurity.

Authors:
Helen Ward

Pediatr Res 2019 Feb 14. Epub 2019 Feb 14.

Bliss, Maya House, 134-138 Borough High Street, London, SE1 1LB, UK.

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http://dx.doi.org/10.1038/s41390-019-0339-2DOI Listing
February 2019

Maternal hypertension and survival in singletons and twins born at 23-29 weeks: not just one answer….

Pediatr Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, QC, Canada.

Objective: To describe the association between maternal hypertension (chronic and gestational, MH) and mortality in very preterm singletons and twins, focusing on how estimates depend on gestational age (GA) and size at birth.

Methods: We estimated relative risks of in-hospital death in 12,320 singletons (MH: 22.4%) and 4381 twins (MH: 10. Read More

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http://dx.doi.org/10.1038/s41390-019-0337-4DOI Listing
February 2019

Impact of Baseline Features and Risk Factor Control on Cognitive Function in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial.

Cerebrovasc Dis 2019 Feb 14;47(1-2):24-31. Epub 2019 Feb 14.

Medical University of South Carolina, Charleston, South Carolina, USA.

Background: Cerebrovascular disease is an important cause of cognitive impairment. The aim of this study is to report the relationship between cognitive function and risk factors at baseline and during follow-up in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial.

Methods: Subjects in the SAMMPRIS trial were included in this study. Read More

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http://dx.doi.org/10.1159/000497245DOI Listing
February 2019

Effectiveness of Scleral Buckling with a Wide-Field Surgical Microscope and Chandelier Illumination in Retinal Detachment Repair.

Ophthalmologica 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Ophthalmology, College of Medicine, Hallym University, Hwaseong, Republic of Korea.

Purpose: To assess treatment efficacy of scleral buckling surgery with wide-field surgical microscope and 27-gauge (G) chandelier illumination for rhegmatogenous retinal detachment (RRD).

Methods: This study is a retrospective chart review of 29 eyes in 29 patients with RRD who underwent scleral buckling surgery with a wide-field surgical microscope and 27-G chandelier illumination fiber inserted into the sclera at the pars plana. Results are expressed as mean ± standard deviation. Read More

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http://dx.doi.org/10.1159/000496165DOI Listing
February 2019

Association of Hand-Foot Skin Reaction with Regorafenib Efficacy in the Treatment of Metastatic Colorectal Cancer.

Oncology 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Pharmacy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Purpose: Hand-foot skin reaction (HFSR) can deteriorate quality of life in patients receiving regorafenib. Cutaneous toxicity is a main adverse effect of multikinase inhibitors and has also been associated with clinical outcome. This study assessed the association between the antitumor efficacy of regorafenib and HFSR in patients with metastatic colorectal cancer (mCRC). Read More

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http://dx.doi.org/10.1159/000495989DOI Listing
February 2019

Prevalence and Characteristics of Restless Legs Syndrome in Korean Adults: A Study in Two Independent Samples of the General Population.

Neuroepidemiology 2019 Feb 14;52(3-4):193-204. Epub 2019 Feb 14.

Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of

Background: Restless legs syndrome (RLS) is a common sleep disorder, although it has a low prevalence in Asian populations. However, the reported RLS prevalence in -Korean adults is mostly 4.5-12. Read More

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http://dx.doi.org/10.1159/000496839DOI Listing
February 2019

Tumor Cavity Recurrence after Stereotactic Radiosurgery of Surgically Resected Brain Metastases: Implication of Deviations from Contouring Guidelines.

Stereotact Funct Neurosurg 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Radiation Oncology, West Virginia University, Morgantown, West Virginia,

Background: Significant heterogeneity exists in target volumes for postoperative stereotactic radiosurgery (SRS) for brain metastases. A set of contouring guidelines was recently published, and we investigated the impact of deviations.

Methods: Patients (n = 41) undergoing single-fraction Gamma Knife SRS following surgical resection of brain metastases from 2011 to 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1159/000496156DOI Listing
February 2019

Diversity of Nontuberculous Mycobacteria In Kuwait: Rapid Identification And Differentiation Of Mycobacterium species by multiplex PCR, INNO-LiPA Mycobacteria v2 assay and PCR-sequencing of rDNA.

Med Princ Pract 2019 Feb 14. Epub 2019 Feb 14.

Objective: Nontuberculous mycobacteria (NTM) often cause disease that is clinically indistinguishable from tuberculosis. Specific identification is important as treatment varies according to Mycobacterium species causing the infection. This study used multiplex PCR (mPCR) assay for rapid differentiation of mycobacterial growth indicator tube 960 system (MGIT) cultures as Mycobacterium tuberculosis (MTB) or NTM together with INNO LiPA Mycobacteria v2 assay (LiPA) and/or PCR-sequencing of rDNA for species-specific identification of selected MTB and all NTM isolates in Kuwait. Read More

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http://dx.doi.org/10.1159/000498910DOI Listing
February 2019

Low Preoperative Prolactin Levels Predict Non-Organ Confined Prostate Cancer in Clinically Localized Disease.

Urol Int 2019 Feb 14:1-9. Epub 2019 Feb 14.

Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

Introduction: To evaluate the association between preoperative serum prolactin (PRL) levels and risk of non-organ confined prostate cancer (PCa) in clinically localized disease.

Materials And Methods: From December 2007 to December 2011, 124 patients with clinically localized PCa were retrospectively evaluated. Non-organ confined disease in the surgical specimen was defined according to extra-capsular extension, seminal vesicle invasion, positive surgical margins, and lymph node invasion. Read More

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http://dx.doi.org/10.1159/000496833DOI Listing
February 2019

Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes.

Ann Nutr Metab 2019 Feb 14;74(2):165-174. Epub 2019 Feb 14.

Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, Nevada,

Background: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes.

Objective: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes. Read More

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http://dx.doi.org/10.1159/000497226DOI Listing
February 2019

The Significance of Yolk Sac Number in Monoamniotic Twins.

Fetal Diagn Ther 2019 Feb 14:1-7. Epub 2019 Feb 14.

The University of Melbourne, Department of Obstetrics and Gynaecology, The Royal Women's Hospital, Parkville, Victoria, Australia.

Background: Detection of a single yolk sac on early first trimester ultrasound was previously thought to be a reliable diagnostic feature of monochorionic monoamniotic (MCMA) twin pregnancies.

Objectives: To determine the frequency of two yolk sacs in MCMA twin pregnancies and the association of yolk sac number with pregnancy outcomes.

Methods: A retrospective cohort analysis of MCMA twins managed at a tertiary obstetric centre from January 2003 until February 2017. Read More

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http://dx.doi.org/10.1159/000496204DOI Listing
February 2019

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study.

Eur Neurol 2019 Feb 14;80(5-6):283-288. Epub 2019 Feb 14.

Medical School of Chinese PLA, Beijing, China.

Background: There are sparse and limited studies on small sample size reporting the application of next-generation sequencing (NGS) in the detection of central nervous system (CNS) viral infections. We assessed the diagnostic performance of NGS of cerebrospinal fluid (CSF) for predicting viral infections of the CNS caused by the neurotropic herpes viruses in a pilot population.

Materials And Methods: We prospectively collected CSF samples from 24 patients with CNS viral infection from April 2017 to October 2018. Read More

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http://dx.doi.org/10.1159/000497319DOI Listing
February 2019

Misplacement of Tunneled Hemodialysis Catheter into Azygos Vein: Left or Right Jugular Insertion Has Similar Susceptibility.

Blood Purif 2019 Feb 14:1-9. Epub 2019 Feb 14.

Department of Nephrology, University of Hong Kong-Shenzhen Hospital, Shenzhen,

Background: Central venous catheter (CVC) is commonly used to provide access for hemodialysis (HD) when arteriovenous access is not available. The misplacement of CVC into azygos vein (AV) is a rare but a potential serious complication. Previous reports communicated the opinion that left-sided catheterization predisposed to AV misplacement, but these reports concentrated on peripherally inserted CVCs, placed for indications rather than HD. Read More

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http://dx.doi.org/10.1159/000497231DOI Listing
February 2019

Comparison of All-Cause and Cause-Specific Mortality of Persons with Traumatic Spinal Cord Injuries to the General Swiss Population: Results from a National Cohort Study.

Neuroepidemiology 2019 Feb 14;52(3-4):205-213. Epub 2019 Feb 14.

Swiss Paraplegic Research, Nottwil, Switzerland.

Background: Traumatic spinal cord injuries (TSCI) are a neurological condition associated with reduced well-being, increased morbidity and reductions in life expectancy. Estimates of all-cause and cause-specific mortality can aid in identifying targets for prevention and management of contributors for premature mortality.

Objectives: To compare all-cause and cause-specific rates of mortality to that of the Swiss general population; to identify differentials in risk of cause-specific mortality according to lesion characteristics. Read More

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http://dx.doi.org/10.1159/000496976DOI Listing
February 2019

Loss of RUNX3 Immunoreactivity in Non-Neoplastic Rectal Mucosa May Predict the Occurrence of Ulcerative Colitis-Associated Colorectal Cancer.

Digestion 2019 Feb 14:1-9. Epub 2019 Feb 14.

Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.

Background/aims: Runt-related transcription factor (RUNX) 3 is a tumor suppressor whose expression is reduced in non-neoplastic rectal mucosa of patients with ulcerative colitis (UC) with coexisting colitis-associated cancer (CAC). We aimed to evaluate RUNX3 utility as a predictive marker for CAC using immunohistochemistry (IHC) for non-neoplastic UC mucosa.

Methods: We retrospectively compared the RUNX3 expression detected by IHC between non-neoplastic rectal biopsy specimens from 20 cases with invasive cancer (CAC group) and 20 cases selected from 138 patients without CAC (non-CAC group) that were treated during the same period (2006-2017) and were matched for sex, duration, extension, and age. Read More

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http://dx.doi.org/10.1159/000497272DOI Listing
February 2019
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