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Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Department of Obstetrics and Gynecology; National Taiwan University Hospital, Taipei 100, Taiwan.

The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. Read More

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK.

Background There is little information on which to base the prognostic counselling as to whether an antenatally diagnosed fetal abdominal cyst will grow or shrink, or need surgery. This study aims to provide contemporary data on prenatally diagnosed fetal abdominal cysts in relation to their course and postnatal outcomes. Methods Fetal abdominal cysts diagnosed over 11 years in a single centre were identified. Read More

Medicine (Baltimore) 2019 Feb;98(7):e14577

Department of Gynecology and Obstetrics, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu.

Cancer antigen 125 (CA125) is a valuable tumor marker for ovarian cancer. Gynecology Imaging Reporting and Data System (GI-RADS) is proved to be effective at identifying the adnexal masses. We investigated whether the combination of these two methods can improve the diagnostic accuracy of ovarian cancer. Read More

Rev Neurosci 2019 Feb 9. Epub 2019 Feb 9.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

White matter injury (WMI) prevents the normal development of myelination, leading to central nervous system myelination disorders and the production of chronic sequelae associated with WMI, such as chronic dyskinesia, cognitive impairment and cerebral palsy. This results in a large emotional and socioeconomic burden. Decreased myelination in preterm infant WMI is associated with the delayed development or destruction of oligodendrocyte (OL) lineage cells, particularly oligodendrocyte precursor cells (OPCs). Read More

Radiology 2019 Feb 5:180801. Epub 2019 Feb 5.

From the Departments of Radiology (E.G., C.H.P., N.S., B.K.) and Emergency Medicine (A.L., H.M.S.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115; and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Mass (B.R.).

Purpose To assess the radiologic findings associated with intimate partner violence (IPV). Materials and Methods Electronic medical records of 185 patients referred to the IPV support program from the emergency department (ED) between January 2015 and October 2016 were retrospectively reviewed and compared with an age- and sex-matched control group of 555 subjects (1:3 ratio of IPV victims to control subjects) who presented to the ED. Reports of all imaging studies performed within 5 years prior to the index ED visit were reviewed. Read More

Pediatr Emerg Med Pract 2019 Feb 1;16(Suppl 2):1-2. Epub 2019 Feb 1.

Chief Resident, Emergency Medicine & Pediatrics, University of Arizona, Tucson, AZ

In the emergency department, gynecologic complaints are common presentations for adolescent girls, who may present with abdominal pain, pelvic pain, vaginal discharge, and vaginal bleeding. The differential diagnosis for these presentations is broad, and further complicated by psychosocial factors, confidentiality concerns, and the need to recognize abuse and sexual assault. This issue provides recommendations for the evaluation and management of obstetric and gynecologic emergencies including infectious, anatomic, and endocrine etiologies. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14350

Department of Laboratory Medicine, West China Second University Hospital, and Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education.

The microdeletions of azoospermia factor (AZF) genes in Y chromosome are greatly associated with male infertility, which is also known as the second major genetic cause of spermatogenetic failure. Accumulating studies demonstrate that the different type of AZF microdeletions in patients reflect different clinical manifestations. Therefore, a better understanding of Y chromosome microdeletions might have broad implication for men health. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Jan 22;234:143-148. Epub 2019 Jan 22.

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy; Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems - Eldor Lab, Innovation Accelerator, CNR, Via Piero Gobetti 101, 40129 Bologna, Italy; Center for Developmental Biology and Reprogramming- CEDEBIOR, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy. Electronic address:

Objective: To study the molecular features of mesenchymal stem cells from Wharton Jelly (WJ-MSCs) of umbilical cord to predict their differentiation capacity.

Design: Comparison of gene expression from mesenchymal stem cells of male and female umbilical cord SETTING: University hospital PATIENT (S): umbilical cords (n = 12, 6 males and 6 females) retrieved from spontaneous full-term vaginal delivery of healthy women INTERVENTION: we analyzed the expression of the stemness related genes C-MYC, OCT4, SOX2 and NANOG and of the epigenetic modulating gene DNA-methyltransferase 1 (DNMT1).

Mean Outcome Measure: WJ-MSCs were isolated by standard procedures and immunophenotypically characterized. Read More

Nat Commun 2019 01 25;10(1):433. Epub 2019 Jan 25.

Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, 610041, Chengdu, China.

Aberrant sperm flagella impair sperm motility and cause male infertility, yet the genes which have been identified in multiple morphological abnormalities of the flagella (MMAF) can only explain the pathogenic mechanisms of MMAF in a small number of cases. Here, we identify and functionally characterize homozygous loss-of-function mutations of QRICH2 in two infertile males with MMAF from two consanguineous families. Remarkably, Qrich2 knock-out (KO) male mice constructed by CRISPR-Cas9 technology present MMAF phenotypes and sterility. Read More

Med Sci Monit 2019 Jan 25;25:730-738. Epub 2019 Jan 25.

Medical Laboratory, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND Berberine, a natural isoquinoline alkaloid derived from Berberis genus plants, has been reported to have anti-cancer effects. While cell behavior can be modulated by long non-coding RNAs (lncRNAs), the contributions of lncRNAs in progression and berberine effects on colorectal cancer are largely unknown. Therefore, the present study investigated the involvement and regulatory function of lncRNA cancer susceptibility candidate 2 (CASC2) during the treatment of human colorectal cancer using berberine. Read More

Pediatr Emerg Med Pract 2019 Feb 1;16(2):1-24. Epub 2019 Feb 1.

Associate Professor of Emergency Medicine and Pediatrics, Department of Emergency Medicine, University of California San Francisco, San Francisco, CA.

In the emergency department, gynecologic complaints are common presentations for adolescent girls, who may present with abdominal pain, pelvic pain, vaginal discharge, and vaginal bleeding. The differential diagnosis for these presentations is broad, and further complicated by psychosocial factors, confidentiality concerns, and the need to recognize abuse and sexual assault. This issue provides recommendations for the evaluation and management of obstetric and gynecologic emergencies including infectious, anatomic, and endocrine etiologies. Read More

J Perinat Neonatal Nurs 2019 Jan/Mar;33(1):89-95

Department of Pediatrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital and Department of Pediatrics, Clinical College of University of Electronic Science and Technology of China (Mr Binzhi Tang and Mss Ling, Chen, and Min Tang, and Mr Binzhi Tang), Chengdu, Sichuan Province, China); and Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, Sichuan Province, China (Ms Qu).

The purpose of this study is to investigate the accuracy and safety of intracavitary electrocardiogram (IC-ECG) guidance for the localization of peripherally inserted central catheter (PICC) in neonatal patients. A total of 160 neonatal patients were randomly assigned to receive either anthropometric measurement combined with IC-ECG guidance (n = 80) or conventional anatomical landmark guidance (n = 80) for PICC catheter tip positioning. The catheter tip position was confirmed by postinsertion radiograph and data were interpreted by independent radiologists. Read More

Front Immunol 2018 8;9:3075. Epub 2019 Jan 8.

Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.

Increasing evidence supports the anti-inflammatory role of estrogens in Multiple Sclerosis (MS), originating from the observation of reduction in relapse rates among women with MS during pregnancy, but the molecular mechanisms are still not completely understood. Using an integrative data analysis, we identified T helper (Th) 17 and T regulatory (Treg) cell-type-specific regulatory regions (CSR) regulated by estrogen receptor alpha (ERα). These CSRs were validated in polarized Th17 from healthy donors (HD) and in peripheral blood mononuclear cells, Th17 and Treg cells from relapsing remitting (RR) MS patients and HD during pregnancy. Read More

J Minim Invasive Gynecol 2019 Jan 16. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, Hospital das Forças Armadas, Lisbon, Portugal (Drs. Mairos and Di Martino).

Study Objective: To assess how the location of intracavitary lesions during office hysteroscopy influences pain scores.

Design: Cohort study.

Setting: Department of Obstetrics and Gynecology, Hospital das Forças Armadas, Lisbon, Portugal. Read More

Histol Histopathol 2019 Jan 18:18085. Epub 2019 Jan 18.

Gynecologic and Obstetric Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Introduction: primary extranodal non-hodgkin vaginal lymphoma (PeNHVL) represents a rare entity, with few data published until now. We present here a series of patients with PeNHVL, analyzing our data as part of a detailed review of the available literature.

Methods: the study included a consecutive series of 6 patients with final diagnosis of PeNHVL admitted at our Institution between January 2000 and December 2017. Read More

Arch Gynecol Obstet 2019 Jan 17. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Ruhr-Universität Bochum - Marien Hospital Herne, Hölkeskampring 40, 44625, Herne, Germany.

Purpose: The Internet has become a widely used source of healthcare information. Many Departments of Obstetrics and Gynecology use their websites for public relations purposes. It is, however, unclear, what relevant stakeholders such as patients, relatives of patients, physicians, and medical students expect of an Obstetrics and Gynecology Department's website. Read More

Aust N Z J Psychiatry 2019 Jan 17:4867418823276. Epub 2019 Jan 17.

1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Background:: Acetaminophen is a widely used medication for fever and pain management during pregnancy. However, recent studies have found a possible connection between maternal prenatal acetaminophen use and attention deficit/hyperactivity disorder in children.

Objective:: We aimed to explore the association between maternal acetaminophen use during pregnancy and the risk of attention deficit/hyperactivity disorder in offspring. Read More

Obstet Gynecol Surv 2019 Jan;74(1):40-49

Leonard D. Palumbo Distinguished Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina Hospitals and Lineberger Comprehensive Cancer Center, Chapel Hill, NC.

Importance: Women in low- and middle-income countries (LMICs) are responsible for the stability of their families. Child survival is directly linked to the health and well-being of their mother. Cancer is the leading cause of morbidity and mortality worldwide, and the incidence and mortality for women from cancer are projected to increase over the coming decades. Read More

Behav Brain Res 2019 Apr 9;362:56-63. Epub 2019 Jan 9.

Stem Cells and Regenerative Medicine Research Center, Sichuan Cord Blood Bank/Sichuan Neo-Life Stem Cell Biotech Inc., Chengdu, 610037, Sichuan, China.

Current treatment options for hypoxic-ischemic encephalopathy (HIE) are limited. Human umbilical cord mesenchymal stem cells (UC-MSCs) and cord blood mononuclear cells (CB-MNCs) offer great potential for the treatment of many neurological diseases. The aim of the present study was to identify which cell type is more effective for the treatment of HIE. Read More

J Minim Invasive Gynecol 2019 Jan 9. Epub 2019 Jan 9.

Department of Obstetrics and Gynecology, Assuta Ashdod University Hospital, Ashdod, Israel (all authors), and the Faculty of Health Sciences, Ben-Gurion University, Beersheba, Israel (Dr. Barel).

Study Objective: To describe the presentation, diagnosis, and management of a patient with abdominal pregnancy and to illustrate the laparoscopic technique used to manage this patient.

Design: A descriptive study approved by our local Institutional Review Board. Consent was given from the patient. Read More

Taiwan J Obstet Gynecol 2019 Jan;58(1):111-116

Fellow, Division of Urogynaecology, Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan, Republic of China; Department of Obstetrics and Gynecology, Dr. Pablo O. Torre Memorial Hospital, Bacolod City, Philippines.

Objective: Vesicovaginal fistulas (VVF) are consequences from obstetric and gynecologic surgery. Treatment approach from either abdominal or vaginal route have its own pros and cons. The study aims to present the anatomical, clinical and lower urinary tract symptom outcomes of women with VVF. Read More

Obstet Gynecol 2018 Nov;132(5):e221-e227

Global surgical care programs present obstetrician-gynecologists with important opportunities to address disparities in women's health and health care worldwide. However, these programs also present a unique set of practical and ethical challenges. Obstetrician-gynecologists are encouraged to participate in surgical care efforts abroad while taking the necessary steps to ensure that their patients can make informed decisions and receive benefit from and are not harmed by their surgical care. Read More

Obstet Gynecol 2018 Nov;132(5):1319-1320

Global surgical care programs present obstetrician-gynecologists with important opportunities to address disparities in women's health and health care worldwide. However, these programs also present a unique set of practical and ethical challenges. Obstetrician-gynecologists are encouraged to participate in surgical care efforts abroad while taking the necessary steps to ensure that their patients can make informed decisions and receive benefit from and are not harmed by their surgical care. Read More

BMC Microbiol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Obstetric & Gynecologic, West China Second University Hospital, Sichuan University, NO. 17.3rd Section, Renmin South Road, Chengdu, Sichuan, 610041, China.

Background: Vulvovaginal candidiasis (VVC) is a common vaginitis caused by Candida species,a frequently recurring condition. Fungal azole-resistant strains with azole-resistance have developed for long and wide explosion to the first-line antifungal azole agent. Bovine lactoferrin (BLF) is a protein from transferrin family secreted by the bovine mammary tissue. Read More

Chem Biol Interact 2019 Feb 3;300:111-122. Epub 2019 Jan 3.

Department of Endocrinology, West China School of Medicine/ West China Hospital, Sichuan University, Chengdu, 610041, PR China. Electronic address:

Objective: This study is performed to investigate the effect of long chain noncoding RNA myocardial infarction associated transcript 1 (MIRT1) on myocardial ischemia reperfusion (I/R) injury in aged diabetic rats.

Methods: The aged diabetic rat model and myocardial I/R injury model were established. Through injecting MIRT1 siRNA into caudal vein of rats, the cardiac function, myocardial pathological injury, myocardial fibrosis, cardiomyocytes apoptosis, oxidative stress and inflammatory injury of myocardial tissue of rats were measured. Read More

J Surg Educ 2019 Jan 2. Epub 2019 Jan 2.

Female Pelvic Medicine and Reconstructive Surgery, Department of Women's Health, Hartford Hospital, Hartford, Connecticut 06106.

Objective: The practice of obstetrics and gynecology poses specific ethical challenges for informed consent (IC). Data regarding resident confidence with the IC process are lacking. Our objective was to evaluate obstetrics and gynecology residents' education, experience, and confidence related to IC. Read More

Surg Neurol Int 2018 28;9:239. Epub 2018 Nov 28.

Department of Surgery, Avicenne Military Hospital of Marrakech, Mohammed V University in Rabat, Morocco.

Background: Primary psoas abscess is an unusual clinical entity rarely encountered in the postpartum period. Only seven cases have been reported to date. Here, we present a woman with a primary psoas abscess caused by and occurred 2 months following a normal vaginal birth. Read More

Nutr Neurosci 2018 Dec 21:1-13. Epub 2018 Dec 21.

a Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu , People's Republic of China.

Objectives: To summarize the current evidence on the association between maternal breastfeeding and the occurrence of attention deficit/hyperactivity disorder (ADHD) in offspring.

Methods: We searched for studies published in English before May 2018 using the PubMed, EMBASE, Cochrane, and Web of Science databases. We included cohort studies, case-control studies, and cross-sectional studies, that focused on the association between maternal breastfeeding and the occurrence of ADHD in offspring. Read More

Arch Gynecol Obstet 2019 Jan 18;299(1):55-68. Epub 2018 Dec 18.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: Inositol (ISL) embraces a family of simple carbohydrates with insulin-sensitizing properties, whose most common isoforms are Myo-inositol (MYO) and D-chiro inositol (DCI). The aim of the present study was to assess the efficacy and safety of ISL supplementation during pregnancy for the prevention of gestational diabetes (GDM).

Methods: We conducted a systematic literature search in electronic databases until October 2017. Read More

World J Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Humanitarian medical organizations provide surgical care for a broad range of conditions including general surgical (GS), obstetric and gynecologic (OBGYN), orthopedic (ORTHO), and urologic (URO) conditions in unstable contexts. The most common humanitarian operation is cesarean section. The objective of this study was to identify the proportion of South African general surgeons who had operative experience and current competency in GS, OBGYN, ORTHO, and URO humanitarian operations in order to evaluate their potential for working in humanitarian disasters. Read More

J Obstet Gynecol Neonatal Nurs 2019 Jan 7;48(1):5-15. Epub 2018 Dec 7.

Objective: To synthesize the results of a scoping review and analysis of health care use data to identify gaps in knowledge related to the health of women in the U.S. military. Read More

Gene 2019 Mar 27;688:13-18. Epub 2018 Nov 27.

Human Sperm Bank, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (SCU-CUHK), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Morphological abnormality of spermatozoa head is a human infertility syndrome caused by spermatogenesis defects. The genetic alterations associated with macrozoospermia, globozoospermia and acephalic spermatozoa are relatively definite, whereas the underlying pathogenesis of small-headed sperm remains unclear. Here, we report a 32-year-old infertile male from a consanguineous family, who presented with 95% of small-headed sperm. Read More

Turk J Urol 2018 Nov 26:1-6. Epub 2018 Nov 26.

Department of Urology, King George's Medical University, Lucknow, India.

Objective: To analyze the patterns of presentation and management for urologic complications of obstetrics and gynecology in the form of genitourinary fistulas at a tertiary referral center and highlight the social issues associated with them.

Material And Methods: We conducted this retrospective study analyzing 311 patients with genitourinary fistulas after obstetric and gynecologic surgeries between January 2005 and January 2018. We recorded the patients' characteristics and area of residence and then analyzed the etiology, surgical management and success rates by grouping the patients into four types of genitourinary fistulas. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Jan 12;232:70-74. Epub 2018 Nov 12.

George Washington University, Department of Obstetrics and Gynecology, Division of Minimally Invasive Gynecologic Surgery, Washington, DC, United States. Electronic address:

Objective: High-risk pregnancy stratification and the use of Progesterone and prophylactic cerclage based on prior obstetrical outcomes and cervical length screening have been successful in curbing the impact of preterm birth. However, a large number of women will still suffer from preterm delivery even with optimal management. Experts agree that a transabdominal cerclage is the next best option for women who fail a transvaginal cerclage in a prior pregnancy. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13146

Department of Pediatrics, West China Second University Hospital.

Background: Premature rupture of the membranes (PROM) is the principal risk factor for neonatal sepsis. Interleukin-6 (IL-6) has been investigated for early diagnosis of neonatal sepsis, but not for diagnosis of neonatal sepsis with PROM. The objective of this study is to investigate the early diagnostic value of IL-6 for neonatal sepsis with PROM. Read More

J Ultrason 2018 ;18(73):162-165

3rd Department of Gynecology, Medical University of Lublin, Lublin, Poland.

Cesarean sections account for approximately 20% of all deliveries worldwide. In Poland, the percentage of women delivering by cesarean section amounts to over 43%. According to studies, the prevalence of cesarean scar defects ranges from 24-70%. Read More

Gynecol Obstet Invest 2018 Nov 16:1-6. Epub 2018 Nov 16.

Department of Obstetrics and Gynecology, Obstetrical-Gynecological Ultrasound Unit, "Sant'Anna Hospital", Turin, Italy.

Background/aims: Abnormally invasive placenta (AIP) includes placenta accreta, increta, and percreta and represents major complications of pregnancy. This study was designed to assess the role of ultrasonography in the identification of AIP among pregnant women with antepartum diagnosis of placenta previa.

Methods: A cross-sectional study was performed between May 2015 and April 2016 in 11 centers, including 242 women with antepartum diagnosis of placenta previa. Read More

Case Rep Obstet Gynecol 2018 22;2018:1805153. Epub 2018 Oct 22.

Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Road, Liwan District, Guangzhou, Guangdong 510150, China.

Uterine prolapse complicating pregnancy is rare. Two cases are presented here: one patient had uterine prolapse at both her second and third pregnancy, and the other developed only once prolapse during pregnancy. This report will analyze etiology, clinical characteristics, complication, and treatment of uterine prolapse in pregnancy. Read More

Ann Surg Oncol 2018 Dec 9;25(Suppl 3):886-887. Epub 2018 Nov 9.

Department of Woman and Child Health, IRCCS Fondazione Policlinico Agostino Gemelli, Rome, Italy.

Pediatr Surg Int 2019 Feb 3;35(2):233-237. Epub 2018 Nov 3.

Department of Pediatric Surgery, International Center for Colorectal and Urogenital Care, Children's Hospital Colorado, University of Colorado, 13123 East 16th Avenue, Anschutz Medical Campus, Box 323, Aurora, CO, 80045, USA.

Purpose: Traditionally, the care of children and adults has been arbitrarily separated into pediatric and adult medicine and surgery. Despite progress in pediatric surgical techniques, patients born with congenital anomalies still suffer from significant functional sequelae, which persist into adulthood. We aim to describe some of the most common problems experienced by adult patients with congenital colorectal malformations. Read More

J Invest Surg 2018 Oct 31:1-6. Epub 2018 Oct 31.

d Gynecologic and Obstetric Clinic, Department of Surgical, Microsurgical and Medical Sciences , University of Sassari , Sassari , Italy.

Aim: To investigate regarding the safety and effectiveness of a balloon catheter (Aqueduct-100 device) to dilate the uterine cervix before operative hysteroscopies. Secondary objectives were to evaluate the duration of the dilatation procedure and to investigate on physicians' satisfaction with the device.

Methods: Fifty women younger than 40 years, wishing pregnancies and diagnosed with apparently benign intrauterine lesions and/or uterine anomalies, were enrolled into this study and submitted to cervical priming with Aqueduct-100 device before operative hysteroscopy. Read More

Rev Neurosci 2018 Oct 31. Epub 2018 Oct 31.

Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, section 3, Renmin South Road, Chengdu, Sichuan 610041, China.

White matter injury, the most common neurological injury in preterm infants, is a major cause of chronic neurological morbidity, including cerebral palsy. Although there has been great progress in the study of the mechanism of white matter injury in newborn infants, its pathogenesis is not entirely clear, and further treatment approaches are required. Animal models are the basis of study in pathogenesis, treatment, and prognosis of white matter injury in preterm infants. Read More

Sci Rep 2018 Oct 30;8(1):16047. Epub 2018 Oct 30.

Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.

The NIMA (never in mitosis, gene A)-related kinase-6 (NEK6), which is implicated in cell cycle control and plays significant roles in tumorigenesis, is an attractive target for the development of novel anti-cancer drugs. Here we describe the discovery of a potent ATP site-directed inhibitor of NEK6 identified by virtual screening, adopting both structure- and ligand-based techniques. Using a homology-built model of NEK6 as well as the pharmacophoric features of known NEK6 inhibitors we identified novel binding scaffolds. Read More

Pan Afr Med J 2018 20;30:145. Epub 2018 Jun 20.

Service d'Urologie, CHU Ibn El Jazzar, Kairouan, Tunisie.

Iatrogenic ureteral lesions may occur after any pelvic surgery. They are severe and can affect renal function and even vital prognosis. This study aimed to determine the clinical aspects and the therapeutic approaches of this injury. Read More

Cardiovasc Diabetol 2018 10 30;17(1):139. Epub 2018 Oct 30.

Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, National Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu, Sichuan, 610041, China.

Background: Early detection of subclinical myocardial dysfunction in patients with diabetes mellitus (DM) is essential for recommending therapeutic interventions that can prevent or reverse heart failure, thereby improving the prognosis in such patients. This study aims to quantitatively evaluate left ventricular (LV) myocardial deformation and perfusion using cardiovascular magnetic resonance (CMR) imaging in patients with type 2 diabetes mellitus (T2DM), and to investigate the association between LV subclinical myocardial dysfunction and coronary microvascular perfusion.

Methods: We recruited 71 T2DM patients and 30 healthy individuals as controls who underwent CMR examination. Read More

J Obstet Gynaecol 2019 Feb 27;39(2):248-252. Epub 2018 Oct 27.

f Department of Pathology, School of Medicine , Baskent University , Ankara , Turkey.

The aim of this study is to present our clinical experience about fertility-sparing procedures in early stage cervical cancer and its obstetrical and oncological outcomes. Between the years 2006 and 2016, a total of 22 early stage cervical cancer patients who underwent a fertility-sparing radical abdominal trachelectomy in our clinic were retrospectively analysed. The median age was 33 (range: 28-39) years. Read More

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2018 Jul;26(4):236-239

The State Budget Institution of Health Care "The M.P. Konchalovsky State Clinical Hospital" of the Moscow Health Care Department, Moscow, 124489, Russia.

The prevalence of habitual miscarriage varies depending on territories of the Russian Federation and other countries. The rate of premature delivery in the Moscow Zelenograd administrative okrug in 2013-2015 in average made up to 4.5%-4. Read More

Clin Infect Dis 2018 Oct 23. Epub 2018 Oct 23.

Department of Medicine, Section of Infectious Diseases, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.

Background: Several studies have reported statistically significant associations of Mycoplasma genitalium with cervicitis, urethritis, or vaginal discharge, although non-significant associations have also been reported. This study examined the associations of M. genitalium with selected sexually transmitted infections (STIs), demographic, behavioral, and clinical factors among women attending a sexually transmitted disease (STD) clinic in New Orleans. Read More

PLoS One 2018 17;13(10):e0205695. Epub 2018 Oct 17.

Joint Laboratory of Reproductive Medicine, SCU-CUHK, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, P. R. China.

Gestational diabetes mellitus (GDM), a high-risk pregnancy complication of great effect on the perinatal health of women and newborns, may cause changes of gut microbiota in mothers and further affect gut microbiota in newborns. This study aimed to investigate the potential effect of mother GDM on newborns' gut microbiota. Meconium DNA was extracted from a total of 34 full-term and C-sectioned newborns, in which 20 newborns had mothers diagnosed with GDM, while 14 had unaffected mothers. Read More

Eur J Obstet Gynecol Reprod Biol 2018 Dec 3;231:25-29. Epub 2018 Oct 3.

Department of Medicine and Surgery, Unit of Surgical Sciences, Obstetrics and Gynecology, University of Parma, Parma, Italy.

Introduction: Umbilical artery blood analysis is assumed to give a picture of the acid-base balance of the infant at birth and is considered the gold standard to diagnose neonatal acidemia at birth. The evaluation of umbilical vein pH has been suggested as an adjunct in order to optimize the understanding of the pathophysiology of the hypoxic events in labor. The objective of this study was to assess the correlation between the Delta pH (vein-to-artery) on the umbilical cord and the intrapartum cardiotocography (CTG) patterns in a selected cohort of acidemic neonates. Read More