20,611 results match your criteria Journal of Nutrition[Journal]


Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Division of Nutritional Sciences, Cornell University, Ithaca, NY.

Background: It has been proposed that the fetus prioritizes iron for hemoglobin production over delivery to tissues. However, few studies have evaluated the interrelations between hemoglobin and multiple iron status biomarkers in umbilical cord blood. A full understanding is needed of how these parameters influence each other within cord blood to fully interpret iron and hematologic status at birth. Read More

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http://dx.doi.org/10.1093/jn/nxy286DOI Listing
February 2019

High Hydrostatic Pressure Processing Better Preserves the Nutrient and Bioactive Compound Composition of Human Donor Milk.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.

Background: When mother's milk is insufficient, pasteurized human donor milk (DM) is the recommended supplement for hospitalized very-low-birth-weight infants. The current method of pasteurization (Holder, 62.5°C, 30 min) negatively affects heat-sensitive nutrients and bioactive proteins. Read More

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http://dx.doi.org/10.1093/jn/nxy302DOI Listing
February 2019

Substitution of Dietary Sulfur Amino Acids by DL-2-hydroxy-4-Methylthiobutyric Acid Increases Remethylation and Decreases Transsulfuration in Weaned Piglets.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Institute of Nutritional Physiology, Dummerstorf, Germany.

Background: DL-2-hydroxy-4-methylthiobutyric acid (DL-HMTBA), an L-methionine (L-Met) hydroxyl analogue, has been suggested to be a dietary L-Met source. How dietary DL-HMTBA compared with L-Met affects whole-body L-Met kinetics in growing individuals is unknown.

Objectives: We determined to what extent DL-HMTBA supplementation of an L-Met-deficient diet affects whole-body L-Met and L-cysteine (L-Cys) kinetics, protein synthesis (PS), and the L-Met incorporation rate in liver protein (L-MetInc) compared with L-Met and DL-Met supplementation in a piglet model. Read More

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http://dx.doi.org/10.1093/jn/nxy296DOI Listing
February 2019

Exposure to a Slightly Sweet Lipid-Based Nutrient Supplement During Early Life Does Not Increase the Preference for or Consumption of Sweet Foods and Beverages by 4-6-y-Old Ghanaian Preschool Children: Follow-up of a Randomized Controlled Trial.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.

Background: Whether consuming sweet foods early in life affects sweet food preferences and consumption later in childhood is unknown.

Objective: We tested the hypothesis that exposure to a slightly sweet lipid-based nutrient supplement (LNS) early in life would not increase preference for or consumption of sweet items at preschool age.

Methods: We followed up children who had participated in a randomized trial in Ghana in which LNS was provided to 1 group of women during pregnancy and 6 mo postpartum and to their infants from ages 6-18 mo (LNS group). Read More

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http://dx.doi.org/10.1093/jn/nxy293DOI Listing
February 2019

Supplementation with N-Acetyl Cysteine Affects Motor and Cognitive Function in Young but Not Old Mice.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX.

Background: N-acetyl cysteine (NAC) is a thiolic antioxidant that is thought to increase cellular glutathione (GSH) by augmenting the concentration of available cysteine, an essential precursor to GSH production. Manipulating redox status can affect brain function, and NAC intake has been associated with improving brain function in models of neurodegenerative diseases.

Objectives: The objective of the study was to determine if short-term dietary supplementation with NAC could ameliorate functional impairment associated with aging. Read More

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http://dx.doi.org/10.1093/jn/nxy287DOI Listing
February 2019

Plasma, Urine, and Adipose Tissue Biomarkers of Dietary Intake Differ Between Vegetarian and Non-Vegetarian Diet Groups in the Adventist Health Study-2.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Adventist Health Study, School of Public Health, Loma Linda University, Loma Linda, CA.

Background: Differences in food composition, nutrient intake, and various health outcomes have been reported for vegetarians and non-vegetarians in the Adventist Health Study-2 (AHS-2) cohort.

Objective: We sought to determine whether biomarkers of dietary intake also differed between individuals classified as vegetarian (vegan, lacto-ovo-vegetarian, pesco-vegetarian, semi-vegetarian) and non-vegetarians based on patterns of consumption of meat, dairy, and eggs.

Methods: Fasting plasma, overnight urine, and adipose tissue samples were collected from a representative subset of AHS-2 participants classified into 5 diet groups (vegan, lacto-ovo-vegetarian, pesco-vegetarian, semi-vegetarian, non-vegetarian) who also completed food-frequency questionnaires. Read More

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http://dx.doi.org/10.1093/jn/nxy292DOI Listing
February 2019

Meals with Similar Fat Content from Different Dairy Products Induce Different Postprandial Triglyceride Responses in Healthy Adults: A Randomized Controlled Cross-Over Trial.

J Nutr 2019 Feb 13. Epub 2019 Feb 13.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Background: Postprandial lipemia is a risk factor for cardiovascular disease. Dairy products differ in nutrient content and food matrix, and little is known about how different dairy products affect postprandial triglyceride (TG) concentrations.

Objective: We investigated the effect of meals with similar amounts of fat from different dairy products on postprandial TG concentrations over 6 h in healthy adults. Read More

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http://dx.doi.org/10.1093/jn/nxy291DOI Listing
February 2019

Best Practices for Dietary Supplement Assessment and Estimation of Total Usual Nutrient Intakes in Population-Level Research and Monitoring.

J Nutr 2019 Feb 8. Epub 2019 Feb 8.

School of Medicine, Wake Forest, Winston-Salem, NC.

The use of dietary supplements (DS) is pervasive and can provide substantial amounts of micronutrients to those who use them. Therefore when characterizing dietary intakes, describing the prevalence of inadequacy or excess, or assessing relations between nutrients and health outcomes, it is critical to incorporate DS intakes to improve exposure estimates. Unfortunately, little is known about the best methods to assess DS, and the structure of measurement error in DS reporting. Read More

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http://dx.doi.org/10.1093/jn/nxy264DOI Listing
February 2019

Atorvastatin Decreases Renal Menaquinone-4 Formation in C57BL/6 Male Mice.

J Nutr 2019 Feb 8. Epub 2019 Feb 8.

Jean Mayer USDA Human Nutrition Research Center on Aging.

Background: Menaquinone-4 (MK4), a vitamin K metabolite, is converted from phylloquinone through a process that requires intermediates of endogenous cholesterol production. Recent evidence suggests that MK4 is involved in kidney function.

Objective: The purpose of this study was to determine the effect of atorvastatin treatment on MK4 formation in young and old male mice. Read More

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http://dx.doi.org/10.1093/jn/nxy290DOI Listing
February 2019

Persistent Food Insecurity Is Associated with Adverse Mental Health among Women Living with or at Risk of HIV in the United States.

J Nutr 2019 Feb 8. Epub 2019 Feb 8.

Division of HIV, Infectious Disease, and Global Medicine.

Background: Food insecurity and mental health negatively affect the lives of women in the United States. Participants in the Women's Interagency HIV Study (WIHS) provided the opportunity to understand the association of food insecurity with depression and mental well-being over time.

Objective: We investigated the association between current and persistent food insecurity and depression among women at risk of or living with HIV in the United States. Read More

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http://dx.doi.org/10.1093/jn/nxy203DOI Listing
February 2019

Maternal-Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4-6 Y in Ghana: Follow-up of a Randomized Trial.

J Nutr 2019 Feb 11. Epub 2019 Feb 11.

Program in International and Community Nutrition, Department of Nutrition, University of California Davis, Davis, CA.

Background: In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, prenatal small-quantity lipid-based nutrient supplements (LNSs) had a positive effect on birth weight. Birth weight may be inversely related to blood pressure (BP) later in life.

Objectives: We examined the effect of the intervention on BP at 4-6 y of age, and maternal and child factors related to BP. Read More

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http://dx.doi.org/10.1093/jn/nxy285DOI Listing
February 2019
2 Reads

Revisiting Dietary Iron Requirement and Deficiency in Indian Women: Implications for Food Iron Fortification and Supplementation.

J Nutr 2019 Feb 9. Epub 2019 Feb 9.

Department of Physiology, St John's Medical College.

Anemia in Indian women continues to be highly prevalent, and is thought to be due to low dietary iron content. The high risk of dietary iron deficiency is based on the Indian Council of Medical Research recommendation of 21 mg/d, but there is a need for a secure and transparent determination of the Estimated Average Requirement (EAR) of iron in this population. In nonpregnant, nonlactating women of reproductive age (WRA), the EAR of iron was determined to be 15 mg/d. Read More

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http://dx.doi.org/10.1093/jn/nxy283DOI Listing
February 2019

Dietary Supplement Use among Infants and Toddlers Aged <24 Months in the United States, NHANES 2007-2014.

J Nutr 2019 Feb 9. Epub 2019 Feb 9.

Office of Dietary Supplements, NIH, Bethesda, MD.

Background: Limited nationally representative data are available on dietary supplement (DS) use and resulting nutrient exposures among infants and toddlers.

Objective: This study evaluated DS use among US infants and toddlers to characterize DS use, estimate nutrient intake from DSs, and assess trends in DS use over time.

Methods: Using nationally representative data from NHANES (2007-2014) and trends over time (1999-2014), we estimated prevalence of DS use and types of products used for US infants and toddlers aged <2 y (n = 2823). Read More

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http://dx.doi.org/10.1093/jn/nxy269DOI Listing
February 2019

Tryptophan Requirement in School-Age Children Determined by the Indicator Amino Acid Oxidation Method is Similar to Current Recommendations.

J Nutr 2019 Feb 11. Epub 2019 Feb 11.

Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: The requirement for dietary tryptophan in school-age children has never been empirically derived.

Objective: The objective of our study was to determine the tryptophan requirement of school-age children using the indicator amino acid oxidation technique.

Methods: Volunteer healthy school-age children, between 8 and 12 y, were enrolled and the oxidation of l-[13C]-phenylalanine to 13CO2 measured in response to graded intakes of dietary tryptophan. Read More

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http://dx.doi.org/10.1093/jn/nxy250DOI Listing
February 2019

The Incidence of Obesity, Assessed as Adiposity, Is Reduced After 1 Year in Primary Schoolchildren by the POIBA Intervention.

J Nutr 2019 Feb 12. Epub 2019 Feb 12.

Agència de Salut Pública de Barcelona, (Public Health Agency, Barcelona), Spain.

Background: Childhood obesity is becoming a serious problem, and prevention programs are needed.

Objective: The purpose of this study was to evaluate, after 1 y, the effectiveness of a multicomponent, school-based obesity intervention program.

Methods: This intervention, conducted in Barcelona, Spain, was a quasi-experimental obesity primary prevention intervention targeting schoolchildren aged 9-10 y. Read More

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http://dx.doi.org/10.1093/jn/nxy259DOI Listing
February 2019

Persistent Food Insecurity's Association with Mental Health of Women Living With or at Risk of HIV: A Call to Action.

J Nutr 2019 Feb 8. Epub 2019 Feb 8.

Department of Nutrition, Simmons College, Boston, MA.

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http://dx.doi.org/10.1093/jn/nxy294DOI Listing
February 2019

High Pancreatic Amylase Expression Promotes Adiposity in Obesity-Prone Carbohydrate-Sensitive Rats.

J Nutr 2019 Feb 8. Epub 2019 Feb 8.

UMR Physiologie de la Nutrition et du Comportement Alimentaire, AgroParisTech, INRA, Université Paris Saclay, Paris, France.

Background: We have reported large differences in adiposity (fat mass/body weight) gain between rats fed a low-fat, high-starch diet, leading to their classification into carbohydrate "sensitive" and "resistant" rats. In sensitive animals, fat accumulates in visceral adipose tissues, leading to the suggestion that this form of obesity could be responsible for rapid development of metabolic syndrome.

Objective: We investigated whether increased amylase secretion by the pancreas and accelerated starch degradation in the intestine could be responsible for this phenotype. Read More

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http://dx.doi.org/10.1093/jn/nxy262DOI Listing
February 2019

Insect Meal as Alternative Protein Source Exerts Pronounced Lipid-Lowering Effects in Hyperlipidemic Obese Zucker Rats.

J Nutr 2019 Feb 6. Epub 2019 Feb 6.

Institute of Animal Nutrition and Nutrition Physiology.

Background: Specific dietary proteins exert strong health-related effects compared with casein.

Objective: Herein, the hypothesis was tested using screening and conventional biochemical and molecular biological techniques that protein-rich insect meal compared with casein influences metabolic health in hyperlipidemic rats.

Methods: A 4-wk feeding trial with male, 8-wk-old homozygous obese Zucker rats (n = 36) and male, 8-wk-old heterozygous lean Zucker rats (n = 12) was performed. Read More

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http://dx.doi.org/10.1093/jn/nxy256DOI Listing
February 2019
1 Read

Ethanolamine Produced from Oleoylethanolamide Degradation Contributes to Acetylcholine/Dopamine Balance Modulating Eating Behavior.

J Nutr 2019 Feb 4. Epub 2019 Feb 4.

INRA, INSERM, Université de Rennes, Nutrition, Metabolisms and Cancer (NuMeCan), Rennes, France.

Oleoylethanolamide is a well-recognized anorectic compound which also has noteworthy effects on food-reward, influencing the acetylcholine (ACh)/dopamine (DA) balance in the cholinergic system. After its administration, oleoylethanolamide is quickly degraded into oleic acid and ethanolamine. The effect of oleic acid on the gut-brain axis has been extensively investigated, whereas ethanolamine has received scarce attention. Read More

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http://dx.doi.org/10.1093/jn/nxy281DOI Listing
February 2019

Dose-Dependent Increases in Whole-Body Net Protein Balance and Dietary Protein-Derived Amino Acid Incorporation into Myofibrillar Protein During Recovery from Resistance Exercise in Older Men.

J Nutr 2019 Feb 4. Epub 2019 Feb 4.

NUTRIM School of Nutrition and Translational Research in Metabolism.

Background: Age-related decline in skeletal muscle mass is at least partly attributed to anabolic resistance to food intake. Resistance exercise sensitizes skeletal muscle tissue to the anabolic properties of amino acids.

Objective: The present study assessed protein digestion and amino acid absorption kinetics, whole-body protein balance, and the myofibrillar protein synthetic response to ingestion of different amounts of protein during recovery from resistance exercise in older men. Read More

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http://dx.doi.org/10.1093/jn/nxy263DOI Listing
February 2019

The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal MiceWe.

J Nutr 2019 Feb 4. Epub 2019 Feb 4.

Wellness & Nutrition Science Institute, R&D Division.

Background: Several types of oligosaccharides are used in infant formula to improve the gut microbiota of formula-fed infants. We previously reported that a combination of 3 oligosaccharides (lactulose, raffinose, and galacto-oligosaccharides; LRG) and Bifidobacterium breve effectively increased B. breve numbers, acetate, and the expression of several immune- and gut hormone-related mRNAs in neonatal mice gut. Read More

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http://dx.doi.org/10.1093/jn/nxy248DOI Listing
February 2019
1 Read

Access to the School Breakfast Program Is Associated with Higher Attendance and Test Scores among Elementary School Students.

J Nutr 2019 Feb 2. Epub 2019 Feb 2.

California Department of Social Services, Sacramento, CA.

Background: The School Breakfast Program (SBP) has grown and evolved substantially since its inception, yet relatively little is known about its impact on school engagement and academic outcomes.

Objectives: The purpose of this study is to estimate the impact of the SBP on school attendance and standardized test scores, as well as how impacts differ among student subpopulations and between traditional and nontraditional program models.

Methods: The study uses administrative data from ∼1000 Wisconsin elementary schools during 2009-2014, including almost all public elementary schools in the state except those in Milwaukee Public School District. Read More

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http://dx.doi.org/10.1093/jn/nxy267DOI Listing
February 2019

DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long-Evans Rats.

J Nutr 2019 Feb 2. Epub 2019 Feb 2.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: Eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) recommendations are frequently stated at 500 mg/d; however, adherence to these recommendations would result in a large global commercial EPA/DHA production deficit. Previously, our laboratory demonstrated that acute DHA intake in rats can increase the capacity for synthesis-secretion of n-3 (ω-3) polyunsaturated fatty acids (PUFAs).

Objective: We aimed to investigate the utility of a dietary DHA cycling strategy that employs 2 wk of repeated DHA feeding for a total of 3 cycles over 12 wk. Read More

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http://dx.doi.org/10.1093/jn/nxy282DOI Listing
February 2019

Spermidine and Voluntary Activity Exert Differential Effects on Sucrose- Compared with Fat-Induced Systemic Changes in Male Mice.

J Nutr 2019 Feb 2. Epub 2019 Feb 2.

Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.

Background: Excess dietary fat and sugar are linked to obesity and metabolic syndrome. Polyamines such as spermidine are implicated in fat accumulation and may support activity-induced weight loss.

Objective: This study tested interventional spermidine supplementation and voluntary activity against fat- and sucrose-induced systemic and gut microbiota changes. Read More

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http://dx.doi.org/10.1093/jn/nxy272DOI Listing
February 2019

Myofibrillar and Mitochondrial Protein Synthesis Rates Do Not Differ in Young Men Following the Ingestion of Carbohydrate with Whey, Soy, or Leucine-Enriched Soy Protein after Concurrent Resistance- and Endurance-Type Exercise.

J Nutr 2019 Jan 29. Epub 2019 Jan 29.

NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Human Biology, Maastricht University Medical Center+, Maastricht, Netherland.

Background: Protein ingestion during recovery from resistance-type exercise increases postexercise muscle protein synthesis rates. Whey protein has been reported to have greater anabolic properties than soy protein, an effect which may be attributed to the higher leucine content of whey.

Objective: The objective of this study was to compare postprandial myofibrillar (MyoPS) and mitochondrial (MitoPS) protein synthesis rates after ingestion of carbohydrate with whey, soy, or soy protein enriched with free leucine (to match the leucine content of whey) during recovery from a single bout of concurrent resistance- and endurance-type exercise in young healthy men. Read More

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http://dx.doi.org/10.1093/jn/nxy251DOI Listing
January 2019

Myofibrillar and Mitochondrial Protein Synthesis Rates Do Not Differ in Young Men Following the Ingestion of Carbohydrate with Milk Protein, Whey, or Micellar Casein after Concurrent Resistance- and Endurance-Type Exercise.

J Nutr 2019 Jan 29. Epub 2019 Jan 29.

NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Human Biology, Maastricht University Medical Center+, Maastricht, Netherlands.

Background: Whey and micellar casein are high-quality dairy proteins that can stimulate postprandial muscle protein synthesis rates. How whey and casein compare with milk protein in their capacity to stimulate postprandial myofibrillar (MyoPS) and mitochondrial (MitoPS) protein synthesis rates during postexercise recovery is currently unknown.

Objective: The objective of this study was to compare postprandial MyoPS and MitoPS rates after protein-carbohydrate co-ingestion with milk protein, whey, or micellar casein during recovery from a single bout of concurrent resistance- and endurance-type exercise in young healthy men. Read More

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http://dx.doi.org/10.1093/jn/nxy244DOI Listing
January 2019

Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study.

J Nutr 2019 Jan 24. Epub 2019 Jan 24.

Departments of Epidemiology, Human Genetics, and Environmental Sciences.

Background: The risk of neural tube defect (NTD)-affected pregnancies is reduced with adequate folic acid intake during early pregnancy. However, NTDs have been observed among offspring of women with adequate folic acid intake. Some of these women are possibly not absorbing enough folic acid. Read More

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http://dx.doi.org/10.1093/jn/nxy246DOI Listing
January 2019
1 Read
3.875 Impact Factor

Sweet Snacks Are Positively and Fruits and Vegetables Are Negatively Associated with Visceral or Liver Fat Content in Middle-Aged Men and Women.

J Nutr 2019 Jan 16. Epub 2019 Jan 16.

Departments of Clinical Epidemiology and.

Background: Visceral adipose tissue (VAT) and hepatic triglyceride content (HTGC) are major risk factors for cardiometabolic diseases.

Objective: We aimed to investigate the association of dietary intake of the main food groups with VAT and HTGC in middle-aged men and women.

Methods: We used data from the Netherlands Epidemiology of Obesity study, a population-based study including 6671 participants aged 45-65 y at baseline. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxy260DOI Listing
January 2019
4 Reads

Nutrition Interventions Integrated into an Existing Maternal, Neonatal, and Child Health Program Reduce Food Insecurity Among Recently Delivered and Pregnant Women in Bangladesh.

J Nutr 2019 Jan;149(1):159-166

Poverty, Health and Nutrition Division, International Food Policy Research Institute, Washington, DC.

Background: Antenatal care may be a means to reduce food insecurity in pregnancy and postpartum periods.

Objective: With the use of a cluster-randomized design, we tested whether participation in nutrition-focused antenatal care intending to improve household knowledge about the importance of nutrition for pregnant and lactating women and encourage allocation of household resources to ensure sufficient quality and quantity of foods, without providing food assistance, would reduce household food insecurity.

Methods: Alive & Thrive integrated nutrition interventions into an existing Maternal, Neonatal, and Child Health (MNCH) program in Bangladesh. Read More

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http://dx.doi.org/10.1093/jn/nxy249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351142PMC
January 2019

Apiaceous and Cruciferous Vegetables Fed During the Post-Initiation Stage Reduce Colon Cancer Risk Markers in Rats.

J Nutr 2019 Jan 15. Epub 2019 Jan 15.

Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN.

Background: Vegetable consumption reduces colon cancer risk when fed in the initiation stage of carcinogenesis; however, the effect of vegetable consumption during the post-initiation stage has rarely been examined.

Objective: We investigated the chemopreventive effects of feeding apiaceous and cruciferous vegetables on colon cancer risk in the post-initiation stage.

Methods: Thirty male Wistar rats (∼5 wk, 92 g) were subcutaneously injected with 1,2-dimethylhydrazine 1 time/wk for 2 wk. Read More

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http://dx.doi.org/10.1093/jn/nxy257DOI Listing
January 2019

Ironing out the Relation between Iron Supplementation and Exercise Performance in the Absence of Anemia.

J Nutr 2019 Jan 10. Epub 2019 Jan 10.

Department of Nutrition, Food, and Exercise Sciences, Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL.

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http://dx.doi.org/10.1093/jn/nxy288DOI Listing
January 2019

Increasing Iron Status through Dietary Supplementation in Iron-Depleted, Sedentary Women Increases Endurance Performance at Both Near-Maximal and Submaximal Exercise Intensities.

J Nutr 2019 Jan 10. Epub 2019 Jan 10.

Division of Nutritional Sciences, Cornell University, Ithaca, NY.

Background: Iron deficiency persists as the most common micronutrient deficiency globally, despite having known detrimental effects on physical performance. Although iron supplementation and aerobic exercise have been examined individually and are known to improve physical performance, the impact of simultaneous iron supplementation and aerobic training remains unclear.

Objective: The aim of this study was to examine the individual and combined effects of iron supplementation and aerobic training on improving maximal and submaximal physical performance in iron-depleted, nonanemic (IDNA) women. Read More

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http://dx.doi.org/10.1093/jn/nxy271DOI Listing
January 2019

Prenatal Iron Deficiency and Replete Iron Status Are Associated with Adverse Birth Outcomes, but Associations Differ in Ghana and Malawi.

J Nutr 2019 Jan 9. Epub 2019 Jan 9.

Program in International and Community Nutrition, Department of Nutrition.

Background: Previous literature suggests a U-shaped relation between hemoglobin concentration and adverse birth outcomes. There is less evidence on associations between iron status and birth outcomes.

Objective: Our objective was to determine the associations of maternal hemoglobin concentration and iron status with birth outcomes. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxy278DOI Listing
January 2019
6 Reads

The Initial Dietary Pattern Should Be Considered when Changing Protein Food Portion Sizes to Increase Nutrient Adequacy in French Adults.

J Nutr 2019 Jan 9. Epub 2019 Jan 9.

UMR PNCA, AgroParisTech, INRA, Université Paris-Saclay, Paris, France.

Background: Patterns of protein food intake are undergoing a transition in Western countries, but little is known about how dietary changes to protein intake affect nutrient adequacy of the diet.

Objectives: Our objective was to identify simple modifications to protein food intake that can gradually increase overall nutrient adequacy.

Methods: We identified patterns of dietary protein intake in 1678 adults from a representative French national dietary survey. Read More

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http://dx.doi.org/10.1093/jn/nxy275DOI Listing
January 2019

Zinc Absorption from Micronutrient Powders Is Low in Bangladeshi Toddlers at Risk of Environmental Enteric Dysfunction and May Increase Dietary Zinc Requirements.

J Nutr 2019 Jan;149(1):98-105

University of Colorado School of Medicine, Department of Pediatrics, Section of Nutrition, Aurora, CO.

Background: Environmental enteric dysfunction (EED), a chronic inflammatory disorder of the small bowel, is suspected to impair absorption of micronutrients, including zinc.

Objective: The objective of this study was to compare zinc absorption from micronutrient powder (MNP) over a range of zinc doses in young children screened for EED with use of the lactulose:mannitol ratio (L:M).

Methods: Bangladeshi children aged 18-24 mo, grouped according to high and low L:M (≥0. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxy245DOI Listing
January 2019
5 Reads

Iron Oversupplementation Causes Hippocampal Iron Overloading and Impairs Social Novelty Recognition in Nursing Piglets.

J Nutr 2019 Jan 8. Epub 2019 Jan 8.

Departments of Animal Science, University of California Davis, Davis, CA.

Background: Iron oversupplementation in healthy term infants may adversely affect growth and cognitive development.

Objective: We hypothesized that early-life iron excess causes systemic and central nervous system iron overload, and compromises social behavior.

Methods: The nursing pig was used as a translational model in a completely randomized study. Read More

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http://dx.doi.org/10.1093/jn/nxy227DOI Listing
January 2019
1 Read

Is the National Cancer Institute's Automated Self-Administered 24-Hour Dietary Assessment Tool Valid for Low-Income Participants?

J Nutr 2019 Jan;149(1):4-5

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.

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http://dx.doi.org/10.1093/jn/nxy252DOI Listing
January 2019

Diet Quality Is Low and Differs by Sex in People with HIV.

J Nutr 2019 Jan;149(1):78-87

Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background: People with HIV (PWH) are at risk for developing metabolic comorbidities driven, in part, by immune activation/inflammation. Little is known about diet quality, a potential modifiable factor in PWH.

Objectives: This study aimed to explore diet quality in terms of conformance with US dietary guidelines by calculating Healthy Eating Index-2010 (HEI) scores among adults with and without HIV in Boston, MA, and determine associations with HEI and markers of immune activation/inflammation. Read More

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http://dx.doi.org/10.1093/jn/nxy241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351143PMC
January 2019

Maternal and Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Increases Infants' Iron Status at 18 Months of Age in a Semiurban Setting in Ghana: A Secondary Outcome Analysis of the iLiNS-DYAD Randomized Controlled Trial.

J Nutr 2019 Jan;149(1):149-158

Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.

Background: Interventions are needed to address iron deficiency in low-income settings.

Objective: This secondary outcome analysis aimed to compare the hemoglobin (Hb) and iron status [zinc protoporphyrin (ZPP)] of children born to women enrolled in the iLiNS-DYAD trial in Ghana.

Methods: Women ≤20 wk pregnant (n = 1320) were assigned to receive 60 mg Fe/d and 400 µg folic acid/d until delivery and placebo thereafter, and no supplementation for infants (IFA group); or multiple micronutrients containing 20 mg Fe/d until 6 mo postpartum and no supplementation for infants (MMN); or small-quantity lipid-based nutrient supplements (SQ-LNSs) containing 20 mg Fe/d until 6 mo postpartum, and SQ-LNSs for infants from 6 to 18 mo of age (LNS). Read More

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http://dx.doi.org/10.1093/jn/nxy225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351141PMC
January 2019
2 Reads

Breakfast Skipping and Type 2 Diabetes: Where Do We Stand?

Authors:
Rania A Mekary

J Nutr 2019 Jan;149(1):1-3

Department of Pharmaceutical Business and Administrative Sciences, School of Pharmacy, MCPHS University, Boston, MA.

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http://dx.doi.org/10.1093/jn/nxy284DOI Listing
January 2019
3.875 Impact Factor

Variable Glycemic Responses to Intact and Hydrolyzed Milk Proteins in Overweight and Obese Adults Reveal the Need for Precision Nutrition.

J Nutr 2019 Jan;149(1):88-97

Institute of Food and Health, University College Dublin School of Agriculture and Food Science, Food for Health Ireland, University College Dublin, Dublin, Ireland.

Background: Dietary modifications can contribute to improved pancreatic β cell function and enhance glycemic control.

Objectives: The objectives of this study were as follows: 1) to investigate the potential of milk protein hydrolysates to modulate postprandial glucose response; 2) to assess individual responses; and 3) to explore the inter- and intraindividual reproducibility of the response.

Methods: A 14-d randomized crossover study investigated interstitial glucose levels of participants in response to 12% w/v milk protein drinks (intact caseinate and casein hydrolysate A and B) consumed in random order with a 2-d washout between treatments. Read More

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https://academic.oup.com/jn/article/149/1/88/5273184
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http://dx.doi.org/10.1093/jn/nxy226DOI Listing
January 2019
2 Reads

Synbiotics Combined with Glutamine Stimulate Brain Development and the Immune System in Preterm Pigs.

J Nutr 2019 Jan;149(1):36-45

Section of Comparative Pediatrics and Nutrition, University of Copenhagen, Denmark.

Background: Preterm infants are born with an immature gut, brain, and immune system, predisposing them to short- and long-term complications.

Objective: We hypothesized that a milk diet supplemented with pre- and probiotics (i.e. Read More

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http://dx.doi.org/10.1093/jn/nxy243DOI Listing
January 2019
7 Reads
3.875 Impact Factor

Saturated Fatty Acid Intake Is Associated with Total Mortality in a Nationwide Cohort Study.

J Nutr 2019 Jan;149(1):68-77

Department of Nutrition, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Dietary intakes of total and specific types of saturated fatty acids (SFAs) in relation to total mortality remain largely unknown in China.

Objective: We assessed the associations of total and individual SFA intakes with total mortality in a Chinese nationwide population.

Methods: This prospective analysis included 7888 women and 6495 men, aged >20 y, from the China Health and Nutrition Survey (1989-2011). Read More

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http://dx.doi.org/10.1093/jn/nxy237DOI Listing
January 2019
1 Read

Methionine Supply During Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta.

J Nutr 2019 Jan;149(1):6-17

Departments of Animal Sciences.

Background: Nonruminant male and female offspring respond differently to gestational nutrition, with placenta contributing to the underlying mechanisms. However, similar data are lacking in large ruminants.

Objectives: The aim of this study was to investigate the impact of methionine supply during late-gestation on metabolism and DNA methylation in placenta from cows carrying male or female calves. Read More

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http://dx.doi.org/10.1093/jn/nxy240DOI Listing
January 2019
2 Reads
3.875 Impact Factor

The Cardiometabolic Risk Profile of Underreporters of Energy Intake Differs from That of Adequate Reporters among Children at Risk of Obesity.

J Nutr 2019 Jan;149(1):123-130

Epidemiology, Biostatistics, and Occupational Health McGill University, Montreal, Quebec, Canada.

Background: Misreporting of energy intake (EI) in nutritional epidemiology is a concern because of information bias, and tends to occur differentially in obese compared with nonobese subjects.

Objective: We examined characteristics of misreporters within a cohort of children with a parental history of obesity and the bias introduced by underreporting.

Methods: The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) cohort included 630 Caucasian children aged 8-10 y at recruitment with ≥1 obese parent [body mass index (BMI; in kg/m2) >30 or waist circumference >102 cm (men), >88 cm (women)] and free of diabetes or severe illness. Read More

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http://dx.doi.org/10.1093/jn/nxy209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351144PMC
January 2019
1 Read

The Provision of Assistance Does Not Substantially Impact the Accuracy of 24-Hour Dietary Recalls Completed Using the Automated Self-Administered 24-H Dietary Assessment Tool among Women with Low Incomes.

J Nutr 2019 Jan;149(1):114-122

Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT.

Background: Evidence is lacking informing the use of the Automated Self-Administered 24-h Dietary Assessment Tool (ASA24) with populations characterized by low income.

Objective: This study was conducted among women with low incomes to evaluate the accuracy of ASA24 recalls completed independently and with assistance.

Methods: Three hundred and two women, aged ≥18 y and with incomes below the Supplemental Nutrition Assistance Program thresholds, served themselves from a buffet; amounts taken as well as plate waste were unobtrusively weighed to enable calculation of true intake for 3 meals. Read More

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http://dx.doi.org/10.1093/jn/nxy207DOI Listing
January 2019

Treatment with DHA Modifies the Response of MDA-MB-231 Breast Cancer Cells and Tumors from nu/nu Mice to Doxorubicin through Apoptosis and Cell Cycle Arrest.

J Nutr 2019 Jan;149(1):46-56

Department of Agricultural, Food & Nutritional Science, Faculty of Agricultural, Life & Environmental Sciences, University of Alberta, Edmonton, Alberta, Canada.

Background: Docosahexaenoic acid (DHA) has been shown to reduce growth of breast cancer cells in vitro and in vivo; it may also benefit the action of cytotoxic cancer drugs. The mechanisms for these observations are not completely understood.

Objectives: We sought to explore how pretreatment of MDA-MB-231 breast cancer cells with DHA alters gene expression with doxorubicin (DOX) treatment and confirm that feeding DHA to tumor-bearing nu/nu mice improves the efficacy of DOX. Read More

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http://dx.doi.org/10.1093/jn/nxy224DOI Listing
January 2019
1 Read

Higher Dairy Intakes Are Associated with Higher Bone Mineral Density among Adults with Sufficient Vitamin D Status: Results from the Boston Puerto Rican Osteoporosis Study.

J Nutr 2019 Jan;149(1):139-148

Department of Biomedical and Nutritional Sciences, University of Massachusetts-Lowell, Lowell, MA.

Background: Dairy foods have been shown to improve bone mineral density (BMD) in non-Hispanic whites. Puerto Rican adults have a higher prevalence of osteoporosis and vitamin D deficiency than non-Hispanic whites. However, there is little understanding of lifestyle influences on bone in this population. Read More

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http://dx.doi.org/10.1093/jn/nxy234DOI Listing
January 2019

Food Insecurity Is More Strongly Associated with Poor Subjective Well-Being in More-Developed Countries than in Less-Developed Countries.

J Nutr 2018 Dec 28. Epub 2018 Dec 28.

Economic Research Service, United States Department of Agriculture, Washington, DC.

Background: Food insecurity is strongly associated with subjective well-being. People compare their well-being to a subjective reference that adjusts over time, which is called hedonic adaptation.

Objective: We aimed to deepen understanding of the relation between food insecurity and subjective well-being among countries from the perspective of possible hedonic adaptation between food insecurity and subjective well-being. Read More

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http://dx.doi.org/10.1093/jn/nxy261DOI Listing
December 2018
10 Reads

A Diabetes-Related Dietary Pattern Is Associated with Incident Diabetes in Obese Men in the Korean Genome Epidemiology Study.

J Nutr 2018 Dec 22. Epub 2018 Dec 22.

Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea.

Background: Diet plays an important role in both the development and management of diabetes.

Objective: Using data from the Korean Genome Epidemiology Study, we assessed dietary patterns associated with the clinical indicators of diabetes.

Methods: This study included 7255 subjects aged 40-69 y. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxy274DOI Listing
December 2018
12 Reads