4,523 results match your criteria Journal of Neurotrauma[Journal]


The Association of Very Early Serum levels of S100B, GFAP, UCH-L1, and SBDP with Outcome in ProTECT III.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

Emory University, Emergency Medicine , Emergency Medicine Research Center , 49 Jesse Hill Jr. Dr. , Atlanta, Georgia, United States , 30303 ;

Rapid risk-stratification of patients with acute traumatic brain injury (TBI) would inform management decisions and prognostication. The objective of this serum biomarker study (BIO-ProTECT) was to test the hypothesis that serum biomarkers of structural brain injury, measured at a single very early timepoint, add value beyond relevant clinical covariates when predicting unfavorable outcome 6-months after moderate-to-severe acute TBI. BIO-ProTECT utilized prospectively collected samples obtained from subjects with moderate-to-severe TBI enrolled in the ProTECT III clinical trial of progesterone. Read More

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http://dx.doi.org/10.1089/neu.2018.5809DOI Listing
February 2019

Low-Dose Testosterone and Evoked Resistance Exercise after Spinal Cord Injury [TEREX-SCI] on Cardio-metabolic Risk Factors: An open-label randomized clinical trial.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

McGuire VA Medical Center, Endocrinology & Metabolism, Richmond, Virginia, United States ;

The purpose of the work is to investigate the effects of low-dose testosterone replacement therapy (TRT) and evoked resistance training (RT) on body composition and metabolic variables after SCI. Twenty-two individuals with chronic motor complete SCI (ages 18-50 years) were randomly assigned to either TRT+RT (n = 11) or TRT (n = 11) for 16 weeks following a 4 -week delayed entry period. TRT+RT men underwent twice weekly progressive RT using electrical stimulation with ankle weights. Read More

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http://dx.doi.org/10.1089/neu.2018.6136DOI Listing
February 2019

Testosterone administration after traumatic brain injury reduces mitochondrial dysfunction and neurodegeneration.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

Universidade Federal do Rio Grande do Sul, 28124, Departamento de Bioquímica, ICBS, Porto Alegre, RS, Brazil ;

Traumatic brain injury (TBI) increases Ca2+ influx into neurons and desynchronizes mitochondrial function leading to energy depletion and apoptosis. This process may be influenced by brain testosterone (TS) levels, which are known to decrease after TBI. We hypothesized that a TS based therapy could preserve mitochondrial neuroenergetics after TBI, thereby reducing neurodegeneration. Read More

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http://dx.doi.org/10.1089/neu.2018.6266DOI Listing
February 2019

Data Dissemination: Shortening the Long Tail of Traumatic Brain Injury Dark Data.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

UCSF, Brain and Spinal Injury Center, Dept Neurosurgery , 1001 Potrero Ave , 1001 Potrero Ave , San Francisco, California, United States , 94110 ;

Translation of traumatic brain injury (TBI) research findings from bench to bedside involves aligning multispecies data across diverse data types including imaging and molecular biomarkers, histopathology, behavior and functional outcomes. In this review we argue that TBI translation should be acknowledged for what it is: a problem of 'big-data' that can be addressed using modern data science approaches. We review the history of the term 'big-data', tracing its origins in internet technology as data that is 'big' according to the 4v's of volume, velocity, variety or veracity and discuss how the term has transitioned into the mainstream of biomedical research. Read More

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http://dx.doi.org/10.1089/neu.2018.6192DOI Listing
February 2019

Specific brain morphometric changes in spinal cord injury: a voxel-based meta-analysis of white and grey matter volume.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

105# jiefang roadJinan, Shandong, China , 250013 ;

We want to investigate degenerative changes of white matter volume (WMV) and grey matter volume (GMV) in individuals after a spinal cord injury (SCI). Published studies of whole-brain voxel-based morphometry (VBM) comparing SCI patients with controls published between 2006 and March 1st, 2018 were collected by searching PubMed, Web of Science, and EMBASE databases. Voxel-wise meta-analyses of GMV and WMV differences between SCI patients and controls were performed separately using seed-based d mapping. Read More

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http://dx.doi.org/10.1089/neu.2018.6205DOI Listing
February 2019

Sex differences in traumatic brain injury: What we know and what we should know.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

University of Kansas Medical Center, Hoglund Brain Imaging Center , 3901 Rainbow Blvd. , Mail Stop 1052 , Kansas City, Kansas, United States , 66160 ;

There is growing recognition of the problem of male bias in neuroscience research, including in the field of traumatic brain injury (TBI) where fewer women than men are recruited to clinical trials and male rodents have predominantly been used as an experimental injury model. Despite TBI being a leading cause of mortality and disability worldwide, sex differences in the pathophysiology and recovery are poorly understood, limiting clinical care and successful drug development. Given growing interest in sex as a biological variable affecting injury outcomes and treatment efficacy, there is a clear need to summarize sex differences in TBI. Read More

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http://dx.doi.org/10.1089/neu.2018.6171DOI Listing
February 2019

Diazepam inhibits post-traumatic neurogenesis and blocks aberrant dendritic development.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

Portland VA Health Care System, Operative Care Division , 3710 SW US Veterans Hospital Rd , P3ANES , Portland, Oregon, United States , 97239.

Traumatic brain injury (TBI) triggers a robust increase in neurogenesis within the dentate gyrus of the hippocampus, but these new neurons undergo aberrant maturation and dendritic outgrowth. Because GABAA receptors (GABAARs) modulate dendritic outgrowth during constitutive neurogenesis and GABAAR-modulating sedatives are often administered to human patients after TBI, we investigated whether the benzodiazepine, diazepam, alters post-injury hippocampal neurogenesis. We used a controlled cortical impact (CCI) model of TBI in adult mice, and administered diazepam or vehicle continuously for one week after injury via osmotic pump. Read More

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http://dx.doi.org/10.1089/neu.2018.6162DOI Listing
February 2019

Diagnostic algorithms to study post-concussion syndrome using electronic health records: validating a method to capture an important patient population.

J Neurotrauma 2019 Feb 16. Epub 2019 Feb 16.

Vanderbilt University School of Medicine, Department of Neurological Surgery , 1211 Medical Center Drive , Dept of Neurosurgery - T-4224 Medical Center North , Nashville, Tennessee, United States , 37212 ;

Post-concussion syndrome (PCS) is characterized by persistent cognitive, somatic, and emotional symptoms after a mild traumatic brain injury (mTBI). Genetic and other biological variables may contribute to PCS etiology, and the emergence of biobanks linked to electronic health records (EHR) offers new opportunities for research on PCS. We sought to validate the use of EHR data of PCS patients by comparing two diagnostic algorithms deployed in the Vanderbilt University Medical Center de-identified database of 2. Read More

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http://dx.doi.org/10.1089/neu.2018.5916DOI Listing
February 2019

Correlation of blood biomarkers and biomarker panels with traumatic findings on computed tomography after traumatic brain injury.

J Neurotrauma 2019 Feb 14. Epub 2019 Feb 14.

Göteborg University, Neuroscience and Physiology , Sahlgrenska University Hospital , Mölndal, Sweden , SE-43180 ;

The aim of the study was to examine the ability of eight protein biomarkers and their combinations in discriminating CT-negative and CT-positive patients with TBI, utilizing highly sensitive immunoassays in a well-characterized cohort. Blood samples were obtained from 160 patients with acute TBI within 24h from admission. Levels of β-amyloid isoforms 1-40 (Aβ40) and 1-42 (Aβ42), glial fibrillary acidic protein (GFAP), heart fatty-acid binding protein (H-FABP), interleukin 10 (IL-10), neurofilament light (NF-L), S100 calcium-binding protein B (S100B) and tau were measured. Read More

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http://dx.doi.org/10.1089/neu.2018.6254DOI Listing
February 2019
1 Read

Assessment of Brain Venous Structure in Military TBI Patients Using Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping.

J Neurotrauma 2019 Feb 14. Epub 2019 Feb 14.

Walter Reed National Military Medical Center, 8395, National Intrepid Center of Excellence, Bethesda, Maryland, United States ;

Brain venous volume above the lateral ventricle in military patients with TBI was assessed using two segmentation approaches on susceptibility weighted images (SWI) and quantitative susceptibility maps (QSM). This retrospective study included a total of 147 subjects: 14 patients with severe TBI; 38 patients with moderate TBI; 58 patients with mild TBI (28 with blast related injuries and 30 with nonblast related injuries) and 37 control subjects without history of TBI. Using the multiscale vessel enhancement filter on SWI images, patients with severe TBI demonstrated significantly higher segmented venous volumes compared to the controls. Read More

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http://dx.doi.org/10.1089/neu.2018.5970DOI Listing
February 2019
1 Read

Deficiency of plasminogen activator inhibitor type 2 limits brain edema formation after traumatic brain injury.

J Neurotrauma 2019 Feb 13. Epub 2019 Feb 13.

Johannes Gutenberg-University, Department of Anesthesiology , Langenbeckstrasse 1 , Mainz, Germany , 55131.

Plasminogen activator inhibitor type 2 (PAI-2 / SerpinB2) inhibits extracellular urokinase plasminogen activator (uPA). Under physiological conditions PAI-2 is expressed at low levels, but is rapidly induced by inflammatory triggers. It is a negative regulator of fibrinolysis and serves to stabilize clots. Read More

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http://dx.doi.org/10.1089/neu.2018.6126DOI Listing
February 2019

Repositioning Flubendazole for Spinal Cord Injury.

J Neurotrauma 2019 Feb 12. Epub 2019 Feb 12.

University of Kentucky, Department of Neuroscience Spinal Cord and Brain Injury Research Center, Lexington, Kentucky, United States ;

We previously reported the serendipitous observation that Fenbendazole, a benzimidazole anthelmintic, improved functional and pathological outcomes following thoracic spinal cord contusion injury in mice when administered pre-injury. Fenbendazole is widely used in veterinary medicine. However, it is not approved for human use and it was uncertain if only post-injury administration would offer similar benefits. Read More

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http://dx.doi.org/10.1089/neu.2018.6160DOI Listing
February 2019

A Role for Postsynaptic Density 95 and its Binding Partners in Models of Traumatic Brain Injury.

J Neurotrauma 2019 Feb 12. Epub 2019 Feb 12.

Rutgers The State University of New Jersey, 242612, Cell Biology and Neuroscience, Piscataway, New Jersey, United States ;

Postsynaptic density 95 (PSD-95), the major scaffold protein at excitatory synapses, plays a major role in mediating intracellular signaling by synaptic N-methyl-D-aspartate (NMDA) type glutamate receptors. Despite the fact that much is known about the role of PSD-95 in NMDA-mediated toxicity, less is known about its role in mechanical injury, and more specifically, in traumatic brain injury. Given that neural circuitry is disrupted after TBI and that PSD-95 and its interactors end-binding protein 3 (EB3) and adenomatous polyposis coli (APC) shape dendrites, we examined whether changes to these proteins and their interactions occur after brain trauma. Read More

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http://dx.doi.org/10.1089/neu.2018.6291DOI Listing
February 2019
2 Reads
3.714 Impact Factor

Biomechanics of acute subdural hematoma in the elderly: A fluid-structure interaction study.

J Neurotrauma 2019 Feb 4. Epub 2019 Feb 4.

Division of Neuronic Engineering, Royal Institute of Technology (KTH), Huddinge, Sweden ;

Acute subdural hematoma (ASDH) due to bridging vein (BV) rupture is a frequent and lethal head injury, especially in the elderly. Brain atrophy has been hypothesized to be a primary pathogenesis associated with the increased risk of ASDH in the elderly. Though decades of biomechanical endeavours have been made to elucidate the potential mechanisms, a thorough explanation for this hypothesis appears lacking. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6143
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http://dx.doi.org/10.1089/neu.2018.6143DOI Listing
February 2019
4 Reads

A pilot investigation of rTMS for post-traumatic brain injury depression: Safety, tolerability and efficacy.

J Neurotrauma 2019 Feb 2. Epub 2019 Feb 2.

Monash Alfred Psychiatric Research Centre, Melbourne, Victoria, Australia ;

Depression following a Traumatic Brain Injury (TBI) is common and difficult to treat using standard approaches. The current study investigated, for the first time, Transcranial Magnetic Stimulation for the treatment of post TBI depression. We specifically assessed the safety, tolerability and efficacy of TMS in this patient population. Read More

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http://dx.doi.org/10.1089/neu.2018.6097DOI Listing
February 2019
1 Read

Inhibition of GSK-3β as a Treatment for the Prevention of Cognitive Deficits After a Traumatic Brain Injury.

J Neurotrauma 2019 Feb 1. Epub 2019 Feb 1.

Saint Louis University, Internal Med/Geriatrics, St. Louis, Missouri, United States ;

Traumatic brain injury (TBI) has many long-term consequences including impairment in memory and changes in mood. GSK-3β in its phosphorylated form (p-GSK-3β) is considered to be a major contributor to memory problems that occur with TBI. We have developed an antisense which targets the GSK-3β (GAO) gene. Read More

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http://dx.doi.org/10.1089/neu.2018.5999DOI Listing
February 2019
1 Read

Improved Outcome with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension.

J Neurotrauma 2019 Feb 1. Epub 2019 Feb 1.

Texas A&M University College of Medicine, 12332, Engineering Medicine, Houston, Texas, United States.

Hypotension worsens outcome after all severities of traumatic brain injury (TBI), with loss of cerebral autoregulation a potential contributor. Previously, we demonstrated that intravenous injection of a high capacity catalytic antioxidant, poly(ethylene)glycol conjugated hydrophilic carbon clusters (PEG-HCCs) rapidly restored cerebral perfusion and acutely restored brain oxidative balance in a TBI model complicated by hemorrhagic hypotension without evidence of toxicity. Here, we tested whether these acute effects translated into behavioral and structural benefit. Read More

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http://dx.doi.org/10.1089/neu.2018.6027DOI Listing
February 2019
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Glucose Dynamics of Cortical Spreading Depolarisation in Acute Brain Injury: A Systematic Review.

J Neurotrauma 2019 Jan 31. Epub 2019 Jan 31.

Cambridge University, Division of Anaesthesia, Box 93 , Box 93 Addenbrooke's Hospital, , Hill's Road , CB2 0QQ , Cambridge, Cambridgeshire, United Kingdom of Great Britain and Northern Ireland , CB2 0QQ ;

Cortical spreading depolarisation (CSD) is an emerging mode of secondary neuronal damage in acute brain injury (ABI). Subsequent repolarisation is a metabolic process requiring glucose. Instances of CSD and glucose derangement are both linked to poor neurological outcome, but their causal inter-relationship is not fully defined. Read More

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http://dx.doi.org/10.1089/neu.2018.6175DOI Listing
January 2019

Exercise-induced alterations in sympathetic-somatomotor coupling in incomplete spinal cord injury.

J Neurotrauma 2019 Jan 30. Epub 2019 Jan 30.

Marquette University, Departmetn of Biomedical Engineering , 1515 West Wisconsin Avenue , Room 206 , Milwaukee, Wisconsin, United States , 53233 ;

The purpose of this study was to understand how high and low intensity locomotor training (LT) affects sympathetic-somatomotor coupling in people with incomplete spinal cord injury (SCI). Proper coupling between sympathetic and somatomotor systems allows controlled regulation of cardiovascular responses to exercise. In people with SCI, altered connectivity between descending pathways and spinal segments impairs sympathetic and somatomotor coordination, which may have deleterious effects during exercise and limit rehabilitation outcomes. Read More

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http://dx.doi.org/10.1089/neu.2018.5719DOI Listing
January 2019

The Effects of Blast-Related Neurotrauma on Aurally-Aided Visual Search while Standing and Walking.

J Neurotrauma 2019 Jan 30. Epub 2019 Jan 30.

Walter Reed National Military Medical Center, 8395, Audiology and Speech Pathology, Bethesda, Maryland, United States ;

Service members (SMs) who have suffered mild traumatic brain injury due to blast exposure (b/TBI) often report post-concussive symptoms consistent with auditory, visual, or vestibular impairments even when they score within the normal range on traditional clinical tests of sensory function. One possible explanation for this discrepancy is that patients who score in the low normal range in more than one sensory modality may be severely impaired in tasks that require multisensory integration. This study evaluated unimodal and multimodal sensory performance in SMs with b/TBI and healthy controls by having them conduct four tasks while walking or standing in an immersive virtual environment: an Auditory Localization task (AL) where they moved a cursor to the perceived location of a sound; a Visual Discrimination task (VD) where they distinguished between two visual targets; an Aurally-Aided Visual Search Task (AAVS) where they used an auditory cue to locate and identify a visual target hidden in a field of visual distractors; and a Visual-Only Visual Search task (VOVS) where they located and identified a visual target in a field of distractors with no auditory cue. Read More

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http://dx.doi.org/10.1089/neu.2018.5630DOI Listing
January 2019
1 Read

Impaired Cerebral Vasoreactivity Despite Symptom Resolution in Sports-Related Concussion.

J Neurotrauma 2019 Jan 29. Epub 2019 Jan 29.

University of Texas Southwestern Medical School, Physical Medicine and Rehabilitation , 5323 Harry Hines , CS2.122 , Dallas, Texas, United States , 75390-9055 ;

Traumatic brain injury (TBI) is associated with increased risk of later-life neurodegeneration and dementia. However, the underpinning mechanisms are poorly understood and secondary injury resulting from perturbed physiological processes play a significant role. Cerebral vasoreactivity (CVR), a measure of hemodynamic reserve, is known to be impaired in TBI. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.5861
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http://dx.doi.org/10.1089/neu.2018.5861DOI Listing
January 2019
9 Reads

Melatonin treatment alleviates spinal cord injury-induced gut dysbiosis in mice.

J Neurotrauma 2019 Jan 29. Epub 2019 Jan 29.

No. 10 Jiaomen North Road, Fengtai DistrictBeijing, China , 100068 ;

Spinal cord injury (SCI) disturbs the autonomic nervous system and induces dysfunction in multiple organs/tissues, such as the gastrointestinal (GI) system. The neuroprotective effects of melatonin in SCI models have been reported; however, it is unclear whether the beneficial effects of melatonin are associated with alleviation of gut dysbiosis. In this study, we showed that daily intraperitoneal injection with melatonin following spinal cord contusion at thoracic level 10 in mice improved intestinal barrier integrity and GI motility, reduced the expression levels of certain pro-inflammatory cytokines, improved animal weight gain and metabolic profiling, and promoted locomotor recovery. Read More

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http://dx.doi.org/10.1089/neu.2018.6012DOI Listing
January 2019
2 Reads
3.714 Impact Factor

In silico model of critical cerebral oxygenation after traumatic brain injury: Implications for rescuing hypoxic tissue.

J Neurotrauma 2019 Jan 28. Epub 2019 Jan 28.

Cambridge University, Division of Anaesthesia, Box 93 , Box 93 Addenbrooke's Hospital, , Hill's Road , CB2 0QQ , Cambridge, Cambridgeshire, United Kingdom of Great Britain and Northern Ireland , CB2 0QQ ;

Cerebral oxygen delivery is central to the modern intensive care of patients with severe traumatic brain injury. Low brain tissue oxygen tension (PbtO2) results from microvascular collapse and diffusion limitation and is associated with adverse outcome. A number of therapies to improve oxygen delivery are known to be effective in improving PbtO2. Read More

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http://dx.doi.org/10.1089/neu.2018.6187DOI Listing
January 2019

Positive allosteric modulation of cholinergic receptors improves spatial learning following cortical contusion injury in mice.

J Neurotrauma 2019 Jan 28. Epub 2019 Jan 28.

Veterans Affairs Greater Los Angeles Healthcare System, Research , 11301 Wilshire Blvd , Bldg 115 Room 319 , Los Angeles, California, United States , 90073 ;

We examined benzyl quinolone carboxylic acid (BQCA), a novel M1 muscarinic positive allosteric modulator, for improving memory and motor dysfunction following cerebral cortical contusion injury (CCI). Adult mice received unilateral motorsensory cortical CCI or sham injury. BQCA (5, 10, 20mg/kg, i. Read More

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http://dx.doi.org/10.1089/neu.2018.6036DOI Listing
January 2019
1 Read

College football players less likely to report concussions and other injuries with increased injury accumulation.

J Neurotrauma 2019 Jan 28. Epub 2019 Jan 28.

Harvard Medical School, Health Care Policy, Boston, Massachusetts, United States ;

Athletes sometimes choose not to report suspected concussions, risking delays in treatment and health consequences. How and why do athletes make these reporting decisions? Using original survey data from a cohort of college football players, we evaluate two assumptions of the current literature on injury reporting. First, that the probability of reporting a concussion or injury is constant over time. Read More

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http://dx.doi.org/10.1089/neu.2018.6161DOI Listing
January 2019
1 Read

Novel speed-controlled automated ladder walking device reveals walking speed as a critical determinant of skilled locomotion after a spinal cord injury in adult rats.

J Neurotrauma 2019 Jan 28. Epub 2019 Jan 28.

Stony Brook University, Physical Therapy, Division of Rehabilitation Sciences , 172 Life Science Building , Stony Brook, New York, United States , 11794.

The horizontal ladder task is an established method to assess skilled locomotor recovery after neurological dysfunction. Walking speed is often used as a standardized measure in locomotor assessment of overground walking in human and pre-clinical studies, but the assessment of walking speed is typically ignored during skilled locomotor tasks. Ample empirical evidence indicates that walking speeds on the horizontal ladder are largely non-uniform after central nervous system trauma, suggesting that it could pose a potential source of variability in assessing motor deficits. Read More

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http://dx.doi.org/10.1089/neu.2018.6152DOI Listing
January 2019
1 Read

Differential expression profiles and functional predication of circRNA in traumatic spinal cord injury of rats.

J Neurotrauma 2019 Jan 25. Epub 2019 Jan 25.

Fengyang Rd 415shanghaishanghai, China , 200000 ;

Recent studies have indicated that circular RNAs (circRNAs) are involved in a variety of human diseases. However, the roles of circRNAs in traumatic spinal cord injury (SCI) remain unknown. Here, we performed RNA-seq to analyze the circRNA expression profile in rat spinal cord after SCI and investigate the relevant mechanisms. Read More

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http://dx.doi.org/10.1089/neu.2018.6366DOI Listing
January 2019

Post-traumatic Stress Symptoms after Pediatric Injury: Relation to Prefrontal-Limbic Circuitry.

J Neurotrauma 2019 Jan 23. Epub 2019 Jan 23.

UT Health Sciences Center Houston, Developmental Pediatrics, Houston, Texas, United States ;

Prefrontal-limbic circuitry is vulnerable to effects of stress and injury. We examined microstructure of prefrontal-limbic circuitry following traumatic brain (TBI) or extracranial injury (EI) and its relation to post-traumatic stress symptoms (PTSS). Participants aged 8 to 15 who sustained mild to severe TBI (n=53) or EI (n=26) in motor vehicle incidents were compared to healthy children (n=38) in a prospective longitudinal study. Read More

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http://dx.doi.org/10.1089/neu.2018.6071DOI Listing
January 2019
5 Reads

Carnosic acid improves outcome after repetitive mild traumatic brain injury.

J Neurotrauma 2019 Jan 23. Epub 2019 Jan 23.

University of Texas Medical School, Neurobiology and Anatomy , PO Box 20708 , 6431 Fannin St, MSB 7.160 , Houston, Texas, United States , 77030 ;

In the majority of cases, the cognitive and behavioral impairments resulting from a mild TBI (also referred to as concussion) wane within days to weeks. In contrast, these impairments can persist for months to years after repetitive mild TBI (rmTBI). The cellular and molecular mechanisms underlying these impairments are not well understood. Read More

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http://dx.doi.org/10.1089/neu.2018.6155DOI Listing
January 2019
1 Read

Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3K/AKT-mTOR signaling following traumatic spinal injuries.

J Neurotrauma 2019 Jan 23. Epub 2019 Jan 23.

Indiana University, Neurological Surgery , 950 E. Walnut St., R2-427 , Indianapolis, Indiana, United States , 46202.

Though mechanisms involved in progression of cell death in spinal cord injury (SCI) have been extensively studied, few are clear targets for translation to clinical application. One of the best-understood mechanisms of cell survival in SCI is phosphatidylinositol-3-kinase (PI3K)/Akt and associated downstream signaling. Clear therapeutic efficacy of a phosphatase and tensin homologue (PTEN) inhibitor called bisperoxovanadium (bpV) has been shown in SCI, traumatic brain injury, stroke, and other neurological disease models in both neuroprotection and functional recovery. Read More

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http://dx.doi.org/10.1089/neu.2018.6294DOI Listing
January 2019
1 Read

Multifocal Neuronal Ultrastructural Abnormalities and Synaptic Alterations in Mice after Low-Intensity Blast Exposure.

J Neurotrauma 2019 Jan 22. Epub 2019 Jan 22.

University of Missouri Columbia, 14716, Pathology and Anatomical Sciences, Columbia, Missouri, United States ;

Service members during military actions or combat training frequently are exposed to primary blast generated by explosive weaponry. The majority of military-related neurotrauma are classified as mild and designated as "invisible injuries" that is prevalent during current conflicts. While the previous experimental blast injury studies using moderate- to high-intensity exposures focused mainly on gross and microscopic neuropathology, our prior studies have shown that low-intensity blast (LIB) exposures resulted in nanoscale subcellular myelin and mitochondrial damages and subsequent behavioral disorders in the absence of gross or detectable cellular damage. Read More

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http://dx.doi.org/10.1089/neu.2018.6260DOI Listing
January 2019

Epidural Spinal Cord Stimulation facilitates immediate restoration of dormant motor and autonomic supraspinal pathways after chronic neurologically complete spinal cord injury.

J Neurotrauma 2019 Jan 22. Epub 2019 Jan 22.

Hennepin County Medical Center, Neurosurgery, Minneapolis, Minnesota, United States.

Epidural Spinal Cord Stimulation (eSCS) in combination with extensive rehabilitation has been reported to restore volitional movement in a select group of subjects after motor-complete spinal cord injury (SCI). Numerous questions about the generalizability of these findings to patients with longer term SCI have arisen, especially regarding the possibility of restoring autonomic function. To better understand the effect of eSCS on volitional movement and autonomic function, two female participants five and ten years after injury at ages 48 and 52 respectively with minimal spinal cord preservation on MRI were implanted with an eSCS system at the vertebral T12 level. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6006
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http://dx.doi.org/10.1089/neu.2018.6006DOI Listing
January 2019
5 Reads

A systematic review of closed head injury models of mild traumatic brain injury in mice and rats.

J Neurotrauma 2019 Jan 19. Epub 2019 Jan 19.

University of Kentucky College of Medicine, Spinal Cord & Brain Injury Research Center , 741 S. Limestone St. , BBSBR B459 , Lexington, Kentucky, United States , 40536 ;

Mild TBI (mTBI) is rapidly becoming a major health concern. Researchers use animal models in order to understand the mechanisms and pathological outcomes of mTBI. There are a variety of different closed head models used within the mTBI field that each reproduce one of the characteristics of mTBI (i. Read More

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http://dx.doi.org/10.1089/neu.2018.6127DOI Listing
January 2019
1 Read

A Comparison of Youth Flag and Tackle Football Head Impact Biomechanics.

J Neurotrauma 2019 Jan 18. Epub 2019 Jan 18.

University of Georgia, Department of Kinesiology , 330 River Rd , Athens, Georgia, United States , 30602 ;

Our purpose was to describe the youth flag football head impact burden and make comparisons to youth tackle football. Head impact frequency and magnitude (linear acceleration[g], rotational acceleration[rad/s2]) were collected from 25 tackle and 25 flag youth football players over one season. Athlete exposure (AE) was defined as one player participating in one session. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6236
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http://dx.doi.org/10.1089/neu.2018.6236DOI Listing
January 2019
3 Reads

Prophylaxis pharmacotherapy to prevent the onset of post traumatic brain injury depression: a systematic review.

J Neurotrauma 2019 Jan 17. Epub 2019 Jan 17.

University of Melbourne, Department of Psychiatry , Melbourne, Australia ;

Background: Depression is a common psychiatric problem following traumatic brain injury (TBI) with reported prevalence rates of 30-77% in the first year post-TBI. Given the negative influence of post-TBI depression on cognition, interpersonal, social, physical and occupational functioning; early initiation of pharmacotherapy to prevent post-TBI depression has been considered. This systematic review will synthesize the available evidence from published studies on the effectiveness and harms of pharmacotherapy for the secondary prevention of post-TBI depression. Read More

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http://dx.doi.org/10.1089/neu.2018.6244DOI Listing
January 2019

Automatic Quantification of Computed Tomography Features in Acute Traumatic Brain Injury.

J Neurotrauma 2019 Feb 1. Epub 2019 Feb 1.

1 Research and Development, icometrix, Leuven, Belgium.

Traumatic brain injury is a complex and diverse medical condition with a high frequency of intracranial abnormalities. These can typically be visualized on a computed tomography (CT) scan, which provides important information for further patient management, such as the need for operative intervention. In order to quantify the extent of acute intracranial lesions and associated secondary injuries, such as midline shift and cisternal compression, visual assessment of CT images has limitations, including observer variability and lack of quantitative interpretation. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6183
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http://dx.doi.org/10.1089/neu.2018.6183DOI Listing
February 2019
4 Reads

An accurate method for histological determination of neural tissue loss/sparing following compression-induced spinal cord injury with optimal reproducibility.

J Neurotrauma 2019 Jan 16. Epub 2019 Jan 16.

Institute of Neurobiology, Biomedical Center of the Slovak Academy of Sciences, Department of Neurodegeneration, Plasticity and Repair , Soltesovej 4-6 , Kosice, Slovakia , 04001 ;

In addition to behavioral testing, the efficacy of neuroprotective therapies applied after spinal cord injury is commonly evaluated by means of histological quantification of spared neural tissue. The primary insult itself, but mainly the pathological processes of secondary injury are the underlying causes of spinal tissue degeneration, the extent of which depends on the injury severity and post-injury time. Underestimation of tissue loss due to spinal cord shrinkage and subjective evaluation (impeding reproducibility) are substantial factors which negatively affect the final results. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6140
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http://dx.doi.org/10.1089/neu.2018.6140DOI Listing
January 2019
3 Reads

Continuous Thermal Diffusion-Based Cerebral Blood Flow Monitoring in Adult Traumatic Brain Injury: A Scoping Systematic Review.

J Neurotrauma 2019 Jan 14. Epub 2019 Jan 14.

Health Sciences Centre, Section of Neurosurgery , GB-1 820 Sherbrook Street , Winnipeg, Manitoba, Canada , R3A1R9 ;

Thermal diffusion flowmetry (TDF) is an appealing candidate for monitoring of cerebral blood flow (CBF) in neurocritical-care patients as it provides absolute measurements with a high temporal resolution, potentially allowing for bedside intervention that could mitigate secondary injury. We performed a systematic review of TDF-regional(r)CBF measurements and their association with A) patient functional outcome B) other neurophysiological parameters C) imaging-based tissue outcomes. We searched MEDLINE, EMBASE, SCOPUS, BIOSIS, GlobalHealth and the Cochrane Databases from inception to October 2018 and relevant conference proceedings published over the last 5 years. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6309
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http://dx.doi.org/10.1089/neu.2018.6309DOI Listing
January 2019
6 Reads

Effect of differently polarized macrophages on proliferation and differentiation of ependymal cells from adult spinal cord.

J Neurotrauma 2019 Jan 14. Epub 2019 Jan 14.

Microbiology, Wuhan University School of Medicine, Wuhan, China ;

Background Ependymal cells (EpCs) are a kind of multipotent stem cells in central canal of adult spinal cord, which proliferate following spinal cord injury (SCI). Although they can differentiate into functional neurons in vitro, EpCs progeny differentiate mainly into astrocytes after SCI, and the mechanism remains unclear. The present study aimed to explore whether neuroinflammation induced by classically activated macrophages (M1) or alternatively activated macrophages (M2) had an effect on EpCs proliferation and/or differentiation. Read More

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http://dx.doi.org/10.1089/neu.2018.6133DOI Listing
January 2019
1 Read

A Novel Role for the Endocannabinoid System in Ameliorating Motivation for Alcohol Drinking and Negative Behavioral Affect Following Traumatic Brain Injury in Rats.

J Neurotrauma 2019 Jan 14. Epub 2019 Jan 14.

Louisiana State University Health Sciences Center, Physiology, New Orleans, Louisiana, United States.

Traumatic brain injury (TBI) is associated with psychiatric dysfunction-including pain, cognitive impairment, anxiety, and increased alcohol use. We previously demonstrated that inhibiting endocannabinoid degradation post-TBI with JZL184 attenuates neuroinflammation and neuronal hyperexcitability at the site of injury and improves neurobehavioral recovery. This study aimed to determine the effect of JZL184 on post-TBI behavioral changes related to psychiatric dysfunction and post-TBI neuroadaptations in brain regions associated with these behaviors. Read More

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http://dx.doi.org/10.1089/neu.2018.5854DOI Listing
January 2019
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How to Translate Time; the Temporal Aspects of Rodent and Human Pathobiological Processes in Traumatic Brain Injury.

J Neurotrauma 2019 Jan 10. Epub 2019 Jan 10.

UCLA School of Medicine, Neurosurgery , NPI 18-228 , Los Angeles, California, United States , 90095 ;

Traumatic brain injury (TBI) triggers multiple pathobiological responses with differing onsets, magnitudes, and durations. Identifying the therapeutic window of individual pathologies is critical for successful pharmacological treatment. Dozens of experimental pharmacotherapies have been successfully tested in rodent models, yet all of them (to date) have failed in clinical trials. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6261
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http://dx.doi.org/10.1089/neu.2018.6261DOI Listing
January 2019
6 Reads

Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice.

J Neurotrauma 2019 Jan 9. Epub 2019 Jan 9.

University of Tasmania, Wicking Dementia Research and Education Centre, Hobart, Tasmania, Australia ;

Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to ageing and the onset of AD pathology is not known. In this study, we have examined the effect of TBI on subsequent beta-amyloid (Aβ) deposition in APP/PS1 (APPSWE/PSEN1dE9) transgenic mice either before (3 months of age) or after the onset (6 months of age) of plaque pathology. Read More

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http://dx.doi.org/10.1089/neu.2018.5982DOI Listing
January 2019
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Derivation and initial validation of clinical phenotypes of children presenting with concussion acutely in the Emergency Department: Latent class analysis of a multicentre, prospective cohort, observational study.

J Neurotrauma 2019 Jan 8. Epub 2019 Jan 8.

Children's Hospital of Eastern Ontario, Clinical Research Unit , 401 Smyth Road , Ottawa, Ontario, Canada , K1H 8L1.

The identification of clinical phenotypes may help parse the substantial heterogeneity that characterizes children with concussion. This study used latent class analysis (LCA) to identify discernible phenotypes among children with acute concussion, and to examine the association between phenotypes and persistent post-concussive symptoms (PPCS) at 4- and 12-weeks post-injury. We conducted LCA of variables representing pre-injury history, clinical presentation, and parent symptom ratings, derived from a prospective cohort, observational study that recruited participants from August 2013 until June 2015 at 9 pediatric Emergency Departments within the Pediatric Emergency Research Canada (PERC) network. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6009
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http://dx.doi.org/10.1089/neu.2018.6009DOI Listing
January 2019
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Sexual dimorphism of pain control: analgesic effects of pioglitazone and azithromycin in chronic spinal cord injury.

J Neurotrauma 2019 Jan 8. Epub 2019 Jan 8.

University of Pittsburgh School of Dental Medicine, 212605, Anesthesia and Perioperative Medicine, Pittsburgh Center for Pain Research, Opioid Research Center, Pittsburgh, Pennsylvania, United States ;

Central neuropathic pain develops in greater than 75% of individuals suffering a spinal cord injury (SCI). Increasingly, sex is recognized as an important biological variable in the development and treatment of peripheral neuropathic pain, but much less is known about the role of sex in central neuropathic pain and its pharmacological inhibition. To test the hypothesis that the efficacy of analgesic therapies differs between males and females in SCI, we used a mouse model of SCI pain to determine the analgesic efficacy of pioglitazone (PIO), an FDA approved drug for the treatment of diabetes, and azithromycin (AZM), a commonly prescribed macrolide antibiotic with immunomodulatory properties. Read More

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http://dx.doi.org/10.1089/neu.2018.6207DOI Listing
January 2019

Prevalence of potentially clinically significant MRI findings in athletes with and without sport-related concussion.

J Neurotrauma 2019 Jan 8. Epub 2019 Jan 8.

Medical College of Wisconsin, Neurosurgery , 8701 Watertown Plank Road , Milwaukee, Wisconsin, United States , 53226 ;

Previous studies have shown that mild traumatic brain injury (mTBI) can cause abnormalities in clinically relevant MRI sequences. No large-scale study, however, has prospectively assessed this in athletes with sport-related concussion (SRC). The goal of the current study was to characterize and compare the prevalence of acute, trauma-related MRI findings and clinically significant, non-specific MRI findings in athletes with and without SRC. Read More

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http://dx.doi.org/10.1089/neu.2018.6055DOI Listing
January 2019
4 Reads

Temporal neurophysiological dynamics in traumatic brain injury - the role of pressure reactivity and optimal cerebral perfusion pressure for predicting outcome.

J Neurotrauma 2018 Dec 29. Epub 2018 Dec 29.

Uppsala University, Department of neuroscience, neurosurgery, Uppsala, Sweden ;

Intracranial pressure (ICP), cerebral perfusion pressure (CPP) and the pressure reactivity index (PRx) have been shown to correlate with outcome after traumatic brain injury (TBI), but their temporal evolution is less studied. Optimal CPP (CPPopt), i.e. Read More

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http://dx.doi.org/10.1089/neu.2018.6157DOI Listing
December 2018

Intracranial Pressure Monitoring in Experimental Traumatic Brain Injury: Implications for Clinical Management.

J Neurotrauma 2018 Dec 29. Epub 2018 Dec 29.

Virginia Commonwealth University , Department of Neurosurgery , 417 North 11th Street, Sixth Floor , P.O. Box 980631 , Richmond, Virginia, United States , 23298-0631 ;

Traumatic brain injury (TBI) is often associated with long-term disability and chronic neurological sequelae. One common contributor to unfavorable outcomes is secondary brain injury, which is potentially treatable and preventable through appropriate management of patients in the neurosurgical intensive care unit NICU. Intracranial pressure (ICP) is currently the predominant neurological-specific physiological parameter used to direct the care of severe TBI (sTBI) patients. Read More

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http://dx.doi.org/10.1089/neu.2018.6145DOI Listing
December 2018
1 Read
3.714 Impact Factor

4-Phenylbutyrate ameliorates anxiety disorder by inhibiting endoplasmic reticulum stress following diffuse axonal injury.

J Neurotrauma 2018 Dec 22. Epub 2018 Dec 22.

Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Department of Neurosurgery , Mo-He Road, Shanghai, China , Shanghai, China , 201999 ;

Diffuse axonal injury (DAI) patients are frequently accompanied by adverse sequelae and psychiatric disorders, such as anxiety, leading to a decreased quality of life, social isolation, and poor outcomes. However, the mechanisms regulating psychiatric disorders post-DAI are not well elucidated. Previous studies showed that endoplasmic reticulum (ER) stress functions as a pivotal factor in neurodegeneration disease. Read More

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http://dx.doi.org/10.1089/neu.2018.6048DOI Listing
December 2018

Plasma TNF alpha is a predictor of persisting symptoms post-concussion in children.

J Neurotrauma 2018 Dec 20. Epub 2018 Dec 20.

Murdoch Childrens Research Institute, 34361, Parkville, Victoria, Australia.

Mild traumatic brain injury (mTBI)-associated blood proteomics has become an emerging focus in the past decade, with the U.S Food and Drug Administration (FDA) recently approving the use of a blood test to determine the necessity of a CT scan following adult mTBI. We now also know that the blood proteome of children is different to that of adults and new evidence suggests that children may take longer to recover from an mTBI. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6042
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http://dx.doi.org/10.1089/neu.2018.6042DOI Listing
December 2018
10 Reads

TBIcare Investigator's response to "Raising the Bar for Traumatic Brain Injury Biomarker Research: Methods Make a Difference" by Papa and Wang.

J Neurotrauma 2018 Dec 20. Epub 2018 Dec 20.

University of Turku, Neurology , Kiinamyllynkatu 4-8 , Turku, Finland , 20520 ;

No abstract. Read More

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http://dx.doi.org/10.1089/neu.2017.5209DOI Listing
December 2018
2 Reads