4,567 results match your criteria Journal of Neurotrauma[Journal]


Intraparenchymal application of mature B lymphocytes improves structural and functional outcome after contusion traumatic brain injury.

J Neurotrauma 2019 Apr 18. Epub 2019 Apr 18.

Massachusetts General Hospital, Pediatric Critical Care Medicine, Boston, Massachusetts, United States ;

Cerebral contusion causes neurological dysfunction mediated in part by inflammatory responses to injury. B lymphocytes are dynamic regulators of the immune system that have not been systematically studied in traumatic brain injury (TBI). We showed previously that topically-applied mature B cells have immuno-modulatory properties and strongly promote tissue regeneration, including cutaneous nerve growth, in acute and chronic skin wounds. Read More

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http://dx.doi.org/10.1089/neu.2018.6368DOI Listing

Modelling the influence of age on neurologic outcome and quality of life one year after traumatic brain injury: a prospective multicenter cohort study.

J Neurotrauma 2019 Apr 16. Epub 2019 Apr 16.

Hopital Albert Michallon, Anesthesiology and Critical care, Grenoble, France ;

After traumatic brain injury (TBI), the relationship between age and outcome at one-year, including quality of life, has been poorly explored. The aim of our study was to describe this relationship in a cohort of TBI patients in a regional trauma system. Consecutive TBI patients with severe lesions on initial brain CT scan were included from July 2014 to July 2016 in two French level-I trauma centers. Read More

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http://dx.doi.org/10.1089/neu.2019.6432DOI Listing

Overview of Systematic Reviews of Aerobic Fitness and Muscle Strength Training after Spinal Cord Injury.

J Neurotrauma 2019 Apr 15. Epub 2019 Apr 15.

The University of Sydney, Faculty of Health Sciences , 75 East Street , Lidcombe, New South Wales, Australia , 2141 ;

The number of systematic reviews on the effects of exercise on aerobic fitness and muscle strength in people with spinal cord injury (SCI) has recently increased. However, the results of some of these reviews are inconclusive or inconsistent. In order to strengthen recommendations, this overview was undertaken to assimilate evidence about the effectiveness of different types of physical activities, exercises and therapeutic interventions for improving aerobic fitness and muscle strength in people with SCI. Read More

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http://dx.doi.org/10.1089/neu.2018.6310DOI Listing
April 2019
1 Read

Glasgow Outcome Scale Measures and Impact on Analysis and Results of a Randomized Clinical Trial of Severe TBI.

J Neurotrauma 2019 Apr 11. Epub 2019 Apr 11.

Baylor College of Medicine, Neurosurgery , One Baylor Plaza , Houston, Texas, United States , 77030 ;

The original unstructured Glasgow Outcome Scale (uGOS) and the newer structured interviews GOS and GOSE have been used widely as outcomes in severe traumatic brain injury (TBI) trials. We compared outcome categories (ranging from dead to good recovery) for each measure in a randomized trial of transfusion threshold and the implications of measure choice and analysis methods for the results of the trial. We planned to explore patient symptomology possibly driving any discrepancies between the patient's uGOS and GOS scores. Read More

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http://dx.doi.org/10.1089/neu.2018.5939DOI Listing
April 2019
1 Read

Stability of Blood Biomarkers of Traumatic Brain Injury.

J Neurotrauma 2019 Apr 10. Epub 2019 Apr 10.

Stanford University Department of Radiology, 209657, Radiology, Neuroradiology Division , 300 Pasteur Dr , Grant Building S047 , Stanford, California, United States , 94305-5105 ;

Blood biomarker tests were recently approved for clinical diagnosis of traumatic brain injury (TBI), yet there are still fundamental questions which need attention. One such question is the stability of putative biomarkers in blood over the course of several days after injury if the sample is unable to be processed into serum or plasma and stored at low temperatures. Blood may not be able to be stored at ultra-low temperatures in austere combat or sports environments. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6053
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http://dx.doi.org/10.1089/neu.2018.6053DOI Listing
April 2019
1 Read

Impact of repetitive mild traumatic brain injury on behavioral and hippocampal deficits in a mouse model of chronic stress.

J Neurotrauma 2019 Apr 9. Epub 2019 Apr 9.

Roskamp Institute, 138517, Sarasota, Florida, United States ;

Clinical studies examining the interaction between traumatic brain injury and stress-related disorders such as PTSD are often complicated by methodological constraints such as heterogeneity in injury type and severity, time post-trauma, and predisposing risk factors. Developing relevant animal models whereby many variables can be efficiently controlled is thus essential towards understanding this elusive relationship. Here, we use our repeated unpredictable stress (RUS) paradigm, in combination with our established mouse model of repetitive mild TBI (r-mTBI), to assess the impact of repeated exposures to these paradigms on behavioral and neurobiological measures. Read More

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http://dx.doi.org/10.1089/neu.2018.6314DOI Listing

Nonverbal hand movement durations indicate post-concussion symptoms of athletes.

J Neurotrauma 2019 Apr 9. Epub 2019 Apr 9.

German Sports University, Department of Neurology, Psychosomatic Medicine, and Psychiatry, Cologne, Germany ;

Methods of post-concussion diagnosis are still of debate, regarding sensitivity, objectivity, reliability, and costs. Spontaneous displays of nonverbal hand movement behavior during interaction are indicative of psychopathology and relatively simple to record and analyze. Increased continuous (/irregular) body-focused hand movement activity in particular indicates psychopathologies that overlap in symptomatology with those of sport related concussions (SRC). Read More

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http://dx.doi.org/10.1089/neu.2019.6385DOI Listing
April 2019
2 Reads

Association of Head Injury with Brain Amyloid Deposition: The ARIC-PET Study.

J Neurotrauma 2019 Apr 9. Epub 2019 Apr 9.

Johns Hopkins University School of Medicine, Neurology, Baltimore, Maryland, United States ;

Our objective was to examine associations of head injury with total and regional brain amyloid deposition. We performed cross-sectional analyses of 329 non-demented participants (81 with prior head injury) in the Atherosclerosis Risk in Communities-Positron Emission Tomography (ARIC-PET) Study who underwent 18-Florbetapir PET imaging in 2012-2014. A history of head injury was defined by self-report or emergency room/hospitalization ICD-9 codes. Read More

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http://dx.doi.org/10.1089/neu.2018.6213DOI Listing
April 2019
3.714 Impact Factor

LONGITUDINAL ANALYSIS OF CORPUS CALLOSUM DIFFUSION TENSOR IMAGING METRICS AND ITS ASSOCIATION WITH NEUROLOGICAL OUTCOME.

J Neurotrauma 2019 Apr 9. Epub 2019 Apr 9.

Hospital 12 de Octubre, Neurosurgery , Crta de Andalucia km 5,4 , Madrid, Madrid, Spain , 28041 ;

Traumatic axonal injury (TAI) is the main cause of cognitive and psychological disfunction after a traumatic brain injury (TBI). Diffusion tensor imaging (DTI) is considered a useful technique for indirect assessment of white matter (WM) integrity after a TBI. Scattered WM alterations and its relationship with patient severity have been discovered in normal appearing conventional magnetic resonance imaging (MRI) studies based on DTI sequences. Read More

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http://dx.doi.org/10.1089/neu.2018.5978DOI Listing

Multidimensional mapping of brain-derived extracellular vesicle (EV) miRNA biomarker for traumatic brain injury diagnostics.

J Neurotrauma 2019 Apr 5. Epub 2019 Apr 5.

University of Pennsylvania, Bioengineering , 210 South 33rd Street , Skirkanich Hall, Bioengineering , Philadelphia, Pennsylvania, United States , 19130 ;

The diagnosis and prognosis of traumatic brain injury (TBI) is complicated by variability in the type and severity of injuries and the multiple endophenotypes that describe each patient's response and recovery to the injury. It has been challenging to capture the multiple dimensions that describe an injury and its recovery to provide clinically useful information. To address this challenge, we have performed an open-ended search for panels of miRNA biomarkers, packaged inside of brain-derived extracellular vesicles (EVs), that can be combined algorithmically to accurately classify various states of injury. Read More

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http://dx.doi.org/10.1089/neu.2018.6220DOI Listing

Diffusion Tensor Imaging in Acute Spinal Cord Injury - A Review of Animal and Human Studies.

J Neurotrauma 2019 Apr 5. Epub 2019 Apr 5.

Medical College of Wisconsin, Department of Neurosurgery , 9200 W Wiscosnin Av , Milwaukee, Wisconsin, United States , 53226 ;

Diffusion tensor imaging (DTI), based on the property of preferential diffusion of water molecules in biological tissue is seeing increasing clinical application in the pathologies of the central nervous system (CNS). Spinal cord injury (SCI) is one such area where the use of DTI allows for the evaluation of changes to microstructure of the spinal cord not detected on routine, conventional magnetic resonance imaging (MRI). The insights obtained from preclinical models of SCI indicate correlation of quantitative DTI indices with histology and function, which points to the potential of DTI as a non-invasive, viable biomarker for integrity of white matter tracts in the spinal cord. Read More

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http://dx.doi.org/10.1089/neu.2019.6379DOI Listing
April 2019
1 Read

Single mild traumatic brain injury deteriorates progressive inter-hemispheric functional and structural connectivity.

J Neurotrauma 2019 Mar 30. Epub 2019 Mar 30.

The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University , No.28 Xianning West Road , Xi'an, China , 710049 ;

The present study aims to examine dynamic inter-hemispheric structural and functional connectivity in mild traumatic brain injury (mTBI) patients with longitudinal observations from early sub-acute to chronic stages within one year. 42 mTBI patients and 42 matched healthy controls underwent clinical and neuropsychological evaluations as well as both diffusion tensor imaging (DTI) and resting state functional MRI scanning. All of the patients were initially evaluated within 14 days post-injury (T-1) and follow-up at 3 months (T-2) and 6-12 months (T-3). Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6196
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http://dx.doi.org/10.1089/neu.2018.6196DOI Listing
March 2019
4 Reads

Association of a functional polymorphism in the CHRFAM7A gene with inflammatory response mediators and neuropathic pain after spinal cord injury.

J Neurotrauma 2019 Mar 29. Epub 2019 Mar 29.

Inova Health System, 3313, Neurosciences, Fairfax, Virginia, United States.

The alpha 7 nicotinic acetylcholine receptor, α7 nAChR, plays a central role in regulating inflammatory responses. Previous studies showed that pharmacological inhibitors of α7nAChR have a pro-inflammatory effect, increasing the circulating levels of cytokines such as tumor necrosis factor alpha (TNFα). This study focused on how genetic polymorphisms of the partially duplicated α7nAChR gene (CHRFAM7A), which is highly expressed in peripheral blood cells, contribute to functional outcome after spinal cord injury (SCI). Read More

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http://dx.doi.org/10.1089/neu.2018.6200DOI Listing
March 2019
1 Read
3.714 Impact Factor

Characterising early and late return to work following traumatic brain injury.

J Neurotrauma 2019 Mar 29. Epub 2019 Mar 29.

Monash University, School of Psychological Sciences, Clayton, Victoria, Australia ;

Facilitating successful return to work (RTW) is a key rehabilitation objective following traumatic brain injury (TBI). This study modelled early (within 6 months) and late (7-34 months) return to work by leveraging a large and comprehensive compensation database. The sample comprised 666 participants with TBI, the majority of whom sustained a moderate or severe injury caused by motor-vehicle accident. Read More

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http://dx.doi.org/10.1089/neu.2018.5850DOI Listing

Postural limits of stability are more predominantly impaired and predictive of subjective balance symptoms than sensory organization in a cohort with Traumatic Brain Injury.

J Neurotrauma 2019 Mar 26. Epub 2019 Mar 26.

National Institutes of Health, Clinical Center, Rehabilitation Medicine Department, Bethesda, Maryland, United States ;

Balance problems are common after a Traumatic Brain Injury (TBI). Symptoms of dizziness, unsteadiness or imbalance have been most frequently attributed to sensory organization problems involving the use of visual, proprioceptive and/or vestibular information for postural control. These problems can be assessed with the Sensory Organization Test (SOT). Read More

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http://dx.doi.org/10.1089/neu.2018.5755DOI Listing

Frequency-Dependent Changes in Resting State EEG Functional Networks After Traumatic Brain Injury in Piglets.

J Neurotrauma 2019 Mar 26. Epub 2019 Mar 26.

University of Pennsylvania, 6572, Bioengineering , 210 S. 33rd St. , 240 Skirkanich Hall , Philadelphia, Pennsylvania, United States , 19104-6321 ;

Traumatic brain injury (TBI) is a major health concern in children, as it can cause chronic cognitive and behavioral deficits. The lack of objective involuntary metrics for the diagnosis of TBI makes prognosis more challenging, especially in the pediatric context, where children are often unable to articulate their symptoms. Resting state electroencephalograms (EEG), which are inexpensive, noninvasive, and do not require subjects to perform cognitive tasks, have not yet been used to create functional brain networks in relation to TBI in children or other animals; here we report the first such study. Read More

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http://dx.doi.org/10.1089/neu.2017.5574DOI Listing

Divergent 6-Month Functional Recovery Trajectories and Predictors after Traumatic Brain Injury: Novel Insights from the COBRIT Study.

J Neurotrauma 2019 Mar 26. Epub 2019 Mar 26.

University of Pittsburgh Medical Center, Neurosurgery , 200 Lothrop Street , Suite B-400 , Pittsburgh, Pennsylvania, United States , 15213 ;

Cross-sectional approaches to outcome assessment may not adequately capture heterogeneity in recovery after traumatic brain injury (TBI). Using latent class mixed models (LCMM), a data-driven analytic that identifies groups of patients with similar trajectories, we identified distinct 6-month functional recovery trajectories in a large cohort (n=1,046) of adults age 18-70 years with complicated mild to severe TBI who participated in the Citicoline Brain Injury Treatment Trial (COBRIT). We used multinomial logistic fixed effect models and backward elimination, forward selection, and forward stepwise selection with several stopping rules to explore baseline predictors of functional recovery trajectory. Read More

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http://dx.doi.org/10.1089/neu.2018.6167DOI Listing
March 2019
1 Read

Diagnosing the GOSE: Structural & Psychometric Properties Using Item Response Theory, A TRACK-TBI Pilot Study.

J Neurotrauma 2019 Mar 23. Epub 2019 Mar 23.

Medical College of Wisconsin, Neurosurgery , 8701 West Watertown Plank Road , Milwaukee, Wisconsin, United States , 53226 ;

The Glasgow Outcome Scale - Extended (GOSE) was designed to assess global outcome following traumatic brain injury (TBI). Since its introduction, several empirically founded criticisms of the GOSE have been raised, including poor reliability; an insensitivity to small but potentially meaningful changes; a tendency to produce ceiling effects; inconsistent associations with neurocognitive, psychological, and quality of life measures; and an inability to assess the multidimensional nature of TBI outcome. The current project took a diagnostic approach to identifying the underlying causes of reported limitations by exploring the internal construct validity of the GOSE at 3 and 6 months post-injury using item response theory (IRT) techniques. Read More

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http://dx.doi.org/10.1089/neu.2018.5998DOI Listing

Impact of a quality improvement program on the neurological outcome of patients with traumatic spinal cord injury. A before-after mono-centric study.

J Neurotrauma 2019 Mar 23. Epub 2019 Mar 23.

1 place Alexis RicordeauNantes, France , 44093 ;

Spine Cord Injury (SCI) is a major cause of severe disability. This study aims to assess the effectiveness of a quality improvement program on neurological recovery after SCI. Before-after study during two phases in one intensive care unit in a University Hospital. Read More

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http://dx.doi.org/10.1089/neu.2018.6298DOI Listing
March 2019
1 Read

The Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injury.

J Neurotrauma 2019 Mar 23. Epub 2019 Mar 23.

University of Calgary, Faculty of Medicine , Alberta Children's Hospital Research Institute , 3330 Hospital Drive NW , HMRB 277 , Calgary, Alberta, Canada , T2N4N1 ;

Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, with patients often suffering from consequences such as cognitive deficits, social abnormalities, anxiety, depression, pain, and motor dysfunction. As these impairments often have a significant impact on the patient's quality of life, a key aim of therapeutic intervention in TBI is to mitigate these effects. Translational strategies to develop such interventions have heavily featured animal models of TBI. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6149
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http://dx.doi.org/10.1089/neu.2018.6149DOI Listing
March 2019
2 Reads

Cost-effectiveness of Erythropoietin in Traumatic Brain Injury (EPO-TBI): A multinational trial based economic analysis.

J Neurotrauma 2019 Mar 23. Epub 2019 Mar 23.

Monash University, ANZIC-RC , Level 6 , The Alfred Centre , 99 Commercial Road , Melbourne, Victoria, Australia , 3004 ;

The EPO-TBI multinational randomised controlled trial found that erythropoietin (EPO), when compared with placebo, did not affect 6 month neurological outcome but reduced illness severity-adjusted mortality in patients with traumatic brain injury (TBI), making the cost effectiveness of EPO in TBI uncertain. The current study uses patient-level data from the EPO-TBI trial to evaluate the cost-effectiveness of EPO in patients with moderate or severe TBI from the healthcare payers' perspective. We addressed the issue of transferability in multinational trials by estimating costs and effects for specific geographical regions of the study (Australia/New Zealand, Europe and Saudi Arabia). Read More

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http://dx.doi.org/10.1089/neu.2018.6229DOI Listing
March 2019
3.714 Impact Factor

Mild Traumatic Brain Injury Affects Cognitive Processing and Modifies Oscillatory Brain Activity during Attentional Tasks.

J Neurotrauma 2019 Apr 10. Epub 2019 Apr 10.

1 Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.

Despite the high prevalence of mild traumatic brain injury (mTBI), current diagnostic tools to objectively assess cognitive complaints after mTBI continue to be inadequate. Our aim was to identify neuronal correlates for cognitive difficulties in mTBI patients by evaluating the possible alterations in oscillatory brain activity during a behavioral task known to be sensitive to cognitive impairment after mTBI. We compared oscillatory brain activity during rest and cognitive tasks (Paced Auditory Serial Addition Test [PASAT] and a vigilance test [VT]) with magnetoencephalography between 25 mTBI patients and 20 healthy controls. Read More

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http://dx.doi.org/10.1089/neu.2018.6306DOI Listing
April 2019
1 Read

Insomnia in adolescents with slow recovery from concussion.

J Neurotrauma 2019 Mar 19. Epub 2019 Mar 19.

University of Calgary, Calgary, Alberta, Canada ;

Sleep disruption can occur following brain injury, however, insomnia prevalence and severity in adolescents with persistent postconcussion symptoms have not been investigated. This study examined: (1) some of the psychometric properties of the Insomnia Severity Index (ISI), (2) the prevalence and severity of insomnia symptoms, and (3) associations between insomnia symptoms and clinical measures of postconcussion symptoms, mental health symptoms, and cognitive tests in adolescents with slow recovery from concussion. Participants (N=121) were adolescents 13-18 years old (mean=16. Read More

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http://dx.doi.org/10.1089/neu.2018.6257DOI Listing
March 2019
2 Reads

Changes in Patient Demographics and Outcomes in the Inpatient Rehabilitation Facility Traumatic Brain Injury Population from 2002 to 2016: Implications for Patient Care & Clinical Trials.

J Neurotrauma 2019 Mar 19. Epub 2019 Mar 19.

Harvard Medical School, Department of Physical Medicine and Rehabilitation, Boston, Massachusetts, United States.

Initial studies examining patient demographics and outcomes in traumatic brain injury (TBI) suggest a trend toward increasing patient age, and decreasing rehabilitation length of stay, but such studies have not been repeated since the passage of healthcare reform legislation, most notably the Affordable Care Act. This study utilized the Uniform Data System for Medical Rehabilitation® (UDSMR®) for patients admitted to medical rehabilitation facilities after sustaining a traumatic brain injury from 1/1/2002 through 12/31/2016. Trends for demographic and medical data were evaluated. Read More

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http://dx.doi.org/10.1089/neu.2018.6014DOI Listing

Paroxysmal Sympathetic Hyperactivity rate in patients in vegetative or minimally conscious state due to severe acquired brain injury evaluated by PSH assessment measure.

J Neurotrauma 2019 Mar 19. Epub 2019 Mar 19.

IBFM-CNR, Neuroimaging Unit, Catanzaro, Italy ;

The rate of paroxysmal sympathetic hyperactivity was retrospectively assessed using the Paroxysmal Sympathetic Hyperactivity-Assessment Measure (PSH-AM) scale in patients with disorders of consciousness due to traumatic and non-traumatic acquired brain injury during the rehabilitation phase.These results were compared with previous studies carried out in the same clinical scenario, in order to verify the prevalence of PSH signs from 1998 to 2014. The entire sample consisted of 140 patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious state (MCS) admitted to a neurorehabilitation subacute unit from June 2010 to December 2014. Read More

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http://dx.doi.org/10.1089/neu.2018.5963DOI Listing

Key Glycolytic Metabolites in Paralyzed Skeletal Muscle Are Altered Seven Days after Spinal Cord Injury in Mice.

J Neurotrauma 2019 Apr 10. Epub 2019 Apr 10.

1 National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York.

Spinal cord injury (SCI) results in rapid muscle atrophy and an oxidative-to-glycolytic fiber-type shift. Those with chronic SCI are more at risk for developing insulin resistance and reductions in glucose clearance than able-bodied individuals, but how glucose metabolism is affected after SCI is not well known. An untargeted metabolomics approach was utilized to investigate changes in whole-muscle metabolites at an acute (7-day) and subacute (28-day) time frame after a complete T9 spinal cord transection in 20-week-old female C57BL/6 mice. Read More

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http://dx.doi.org/10.1089/neu.2018.6144DOI Listing
April 2019
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Unbiased Recursive Partitioning to Stratify Patients with Acute Traumatic Spinal Cord Injuries: External Validity in an Observational Cohort Study.

J Neurotrauma 2019 Apr 10. Epub 2019 Apr 10.

1 Department of Orthopedics, University of British Columbia, Vancouver, British Columbia, Canada.

Clinical trials of novel therapies for acute spinal cord injury (SCI) are challenging because variability in spontaneous neurologic recovery can make discerning actual treatment effects difficult. Unbiased Recursive Partitioning regression with Conditional Inference Trees (URP-CTREE) is a novel approach developed through analyses of a large European SCI database (European Multicenter Study about Spinal Cord Injury). URP-CTREE uses early neurologic impairment to predict achieved motor recovery, with potential to optimize clinical trial design by optimizing patient stratification and decreasing sample sizes. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6335
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http://dx.doi.org/10.1089/neu.2018.6335DOI Listing
April 2019
5 Reads
3.714 Impact Factor

Risk of intracranial complications in minor head injury: the role of loss of consciousness and posttraumatic amnesia in a multicenter observational study.

J Neurotrauma 2019 Mar 12. Epub 2019 Mar 12.

Erasmus MC University Medical Center Rotterdam, Department of Neurology, Rotterdam, Zuid-Holland, Netherlands ;

Various guidelines for minor head injury focus on patients with a Glasgow Coma Scale (GCS) score of 13-15 and loss of consciousness (LOC) or posttraumatic amnesia (PTA), while clinical management for patients without LOC or PTA is often unclear. We aimed to investigate the effect of presence and absence of LOC or PTA on intracranial complications in minor head injury. A prospective multicenter cohort study of all patients with blunt head injury and GCS score of 15 was conducted at six Dutch centers between 2015 and 2017. Read More

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http://dx.doi.org/10.1089/neu.2018.6354DOI Listing

Prognosis of 6-month Glasgow Outcome Scale in severe traumatic brain injury using hospital admission characteristics, injury severity characteristics, and physiological monitoring during the first day post-injury.

J Neurotrauma 2019 Mar 12. Epub 2019 Mar 12.

Baylor College of Medicine, Neurosurgery , One Baylor Plaza , Houston, Texas, United States , 77030 ;

Gold standard prognostic models for long-term outcome in patients with severe traumatic brain injury (TBI) use admission characteristics and are considered useful in some areas but not for clinical practice. In this study, we aimed to build prognostic models for 6-month Glasgow Outcome scale (GOS) in patients with severe TBI, combining baseline characteristics with physiological, treatment, and injury severity data collected during the first 24 hours after injury. We used a training dataset of 472 TBI subjects and several data mining algorithms to predict the long-term neurological outcome. Read More

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http://dx.doi.org/10.1089/neu.2018.6217DOI Listing

TMS-EEG measures of cortical inhibition and neuroplasticity are altered following mild traumatic brain injury.

J Neurotrauma 2019 Mar 8. Epub 2019 Mar 8.

Adelaide, Australia ;

While the potential long-term side effects of mild traumatic brain injury (mTBI) are becoming increasingly recognised, the associated neurophysiological mechanisms remain poorly understood. However, changes in cortical inhibitory function and neuroplasticity have been suggested as possible contributing factors. The current study applied transcranial magnetic stimulation (TMS) in conjunction with electroencephalography (combined TMS-EEG) to further investigate the effects of mTBI on these processes. Read More

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http://dx.doi.org/10.1089/neu.2018.6353DOI Listing
March 2019
1 Read

The Apolipoprotein E4 polymorphism and outcomes from traumatic brain injury: a living systematic review and meta-analysis.

J Neurotrauma 2019 Mar 8. Epub 2019 Mar 8.

University of Cambridge, Head, Division of Anaesthesia, Cambridge, Cambs, United Kingdom of Great Britain and Northern Ireland ;

The mortality of traumatic brain injury (TBI) has been largely static despite advances in monitoring and imaging techniques. Substantial variance exists in outcome, not fully accounted for by baseline characteristics or injury severity, and genetic factors likely play a role in this variance. The aims of this systematic review were to examine the evidence for a link between the Apolipoprotein E4 (APOE4) polymorphism and TBI outcomes and, where possible, to quantify the effect size via meta-analysis. Read More

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http://dx.doi.org/10.1089/neu.2018.6052DOI Listing

Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion.

J Neurotrauma 2019 Apr 10. Epub 2019 Apr 10.

1 Department of Physiology, Anatomy, and Microbiology, La Trobe University, Bundoora, Australia.

Rodent models can provide insights into the most pertinent issues surrounding concussion. Nonetheless, the relevance of some existing models to clinical concussion can be questioned, particularly with regard to the use of surgery and anesthesia and the mechanism and severity of injury. Accordingly, we have co-developed an awake closed-head injury (ACHI) model in rats. Read More

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http://dx.doi.org/10.1089/neu.2018.6169DOI Listing
April 2019
8 Reads

Serum Neurofilament Light is Elevated Differentially in Older Adults with Uncomplicated Mild Traumatic Brain Injuries.

J Neurotrauma 2019 Mar 7. Epub 2019 Mar 7.

Tampere University Hospital and University of Tampere, Department of Neurosurgery, Tampere, Finland ;

Neurofilament light (NF-L) might have diagnostic and prognostic potential as a blood biomarker for mild traumatic brain injury (MTBI). However, elevated NF-L is associated with several neurological disorders associated with older age, which could confound its usefulness as a TBI biomarker. We examined whether NF-L is elevated differentially following uncomplicated MTBI in older adults with pre-injury neurological disorders. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6341
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http://dx.doi.org/10.1089/neu.2018.6341DOI Listing
March 2019
5 Reads
3.714 Impact Factor

Endogenous Interleukin-10 Deficiency Exacerbates Vascular Pathology in Traumatic Cervical Spinal Cord Injury.

J Neurotrauma 2019 Mar 7. Epub 2019 Mar 7.

University Health Network, Division of Genetics and Development, Krembil Research Institute, Toronto, Ontario, Canada.

Although the majority of traumatic spinal cord injuries (SCI) take place at the cervical level, preclinical studies have been disproportionally focused on thoracic insults. With differences in anatomy, physiology and immune response between spinal cord levels, there is evidence that injury pathophysiology may vary, requiring tailored treatment paradigms. Further, as only a few therapies have been successfully translated to the clinic, cervical models are increasingly recognized as essential for the characterization of trauma and therapy. Read More

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http://dx.doi.org/10.1089/neu.2018.6081DOI Listing

Improving Understanding and Outcomes of Traumatic Brain Injury Using Bidirectional Translational Research.

J Neurotrauma 2019 Mar 5. Epub 2019 Mar 5.

University of Washington, 7284, Anesthesiology & Pain Medicine, Seattle, Washington, United States.

Recent clinical trials in traumatic brain injury (TBI) have failed to demonstrate therapeutic effects even when there appears to be good evidence for efficacy in one or more appropriate preclinical models. While existing animal models mimic the injury, difficulties in translating promising therapeutics are exacerbated by the lack of alignment of discrete measures of the underlying injury pathology between the animal models and human subjects. To address this mismatch, we have incorporated reverse translation of bedside experience to inform preclinical studies in a large animal (pig) model of TBI that mirror practical clinical assessments. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6119
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http://dx.doi.org/10.1089/neu.2018.6119DOI Listing
March 2019
5 Reads

Plasma Tau and Amyloid Are Not Reliably Related to Injury Characteristics, Neuropsychological Performance, or White Matter Integrity in Service Members with a History of Traumatic Brain Injury.

J Neurotrauma 2019 Apr 9. Epub 2019 Apr 9.

1 Defense and Veterans Brain Injury Center, and Walter Reed National Military Medical Center, Bethesda, Maryland.

The aim of this study was to examine the relationship between plasma tau and amyloid beta-42 (Aβ42), neuropsychological functioning, and white matter integrity in U.S. military service members with (n = 155) and without (n = 42) a history of uncomplicated mild (n = 83), complicated mild (n = 26), or moderate, severe, or penetrating (n = 46) traumatic brain injury (TBI). Read More

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http://dx.doi.org/10.1089/neu.2018.6269DOI Listing
April 2019
2 Reads

Vergence Endurance Test: A Pilot Study for a Concussion Biomarker.

J Neurotrauma 2019 Mar 28. Epub 2019 Mar 28.

1 Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey.

The Vergence Endurance Test (VET), a quantitative and objective eye movement assessment, was utilized to differentiate control from concussed subjects. Nine symptomatic concussed (2 male; 30.8 ± 11 years) and 9 asymptomatic control (6 male; 25. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6075
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http://dx.doi.org/10.1089/neu.2018.6075DOI Listing
March 2019
6 Reads

MicroRNA biomarkers in cerebrospinal fluid and serum reflect injury severity in human acute traumatic spinal cord injury.

J Neurotrauma 2019 Mar 2. Epub 2019 Mar 2.

University of British Columbia, Vancouver Spine Surgery Institute (VSSI), Department of Orthopaedics, Division of Spine, Vancouver, British Columbia, Canada.

Spinal cord injury (SCI) is a devastating condition with variability in injury mechanisms and neurologic recovery. Spinal cord impairment following SCI is measured and classified by a widely accepted standard neurologic examination. However, in the very acute stages post-injury, this examination is extremely challenging (and often impossible) to conduct, and has modest prognostic value in terms of neurologic recovery. Read More

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http://dx.doi.org/10.1089/neu.2018.6256DOI Listing
March 2019
5 Reads

Functional Status Examination versus Glasgow Outcome Scale Extended as outcome measures in Traumatic Brain Injuries: How do they compare?

J Neurotrauma 2019 Mar 2. Epub 2019 Mar 2.

University of Washington, Seattle, Washington, United States ;

Outcome measures are essential components of natural history studies of recovery and treatment effects following traumatic brain injury (TBI). The Glasgow Outcome Scale (GOS) and its revised version, the Glasgow Outcome Scale Extended (GOSE), are well accepted and widely used for both observational and intervention studies, but there are concerns about their psychometric properties and aptness as outcome measures for TBI. The present study compares the Functional Status Examination (FSE) with the GOSE to assess outcome following TBI in a sample of 533 participants with TBI from the Magnesium Sulfate study and the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study by evaluating the sensitivity of each measure to severity of brain injury and recovery of function over time. Read More

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http://dx.doi.org/10.1089/neu.2018.6198DOI Listing

Differences in Morphometric Measures of the Uninjured Porcine Spinal Cord and Dural Sac Predict Histological and Behavioral Outcomes after Traumatic SCI.

J Neurotrauma 2019 Feb 28. Epub 2019 Feb 28.

University of British Columbia, International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.

One of the challenges associated with conducting experiments in animal models of traumatic spinal cord injury (SCI) is inducing a consistent injury with minimal variability in the degree of tissue damage and resultant behavioural and biochemical outcomes. Here, we evaluated how the variability in morphometry of the spinal cord and surrounding cerebrospinal fluid (CSF) contributes to the variability in behavioral and histologic outcomes in our porcine model of SCI. Using intra-operative ultrasound imaging, spinal cord morphometry was assessed in 7 Yucatan mini-pigs undergoing a weight-drop T10 contusion-compression injury. Read More

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http://dx.doi.org/10.1089/neu.2018.5930DOI Listing
February 2019

Pharmacological Optimization for Successful Traumatic Brain Injury Drug Development.

J Neurotrauma 2019 Apr 10. Epub 2019 Apr 10.

2 Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Princeton, New Jersey.

The purpose of this review is to highlight the pharmacological barrier to drug development for traumatic brain injury (TBI) and to discuss best practice strategies to overcome such barriers. Specifically, this article will review the pharmacological considerations of moving from the disease target "hit" to the "lead" compound with drug-like and central nervous system (CNS) penetrant properties. In vitro assessment of drug-like properties will be detailed, followed by pre-clinical studies to ensure adequate pharmacokinetic and pharmacodynamic characteristics of response. Read More

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http://dx.doi.org/10.1089/neu.2018.6295DOI Listing
April 2019
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The impact of early (<24h) surgical decompression on neurological recovery in thoracic spinal cord injury: a meta-analysis.

J Neurotrauma 2019 Feb 28. Epub 2019 Feb 28.

VU medisch centrum, 1209, Neurosurgery , PO Box 7057 , Amsterdam, Netherlands , 1007MB ;

The impact of surgical timing in neurological recovery in thoracic and thoracolumbar traumatic spinal cord injury (tSCI) is still a subject of discussion. While in cervical tSCI one may expect a beneficial effect of early intervention within 24 hours, especially in complete cases, this has not yet been demonstrated clearly for thoracic tSCI. This study addresses neurological improvement after early and late surgery for thoracic and thoracolumbar tSCI. Read More

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http://dx.doi.org/10.1089/neu.2018.6277DOI Listing
February 2019

Pre-Clinical Evaluation of CBD-NT3 Modified Collagen Scaffolds in Completely Spinal Cord Transected Non-Human Primates.

J Neurotrauma 2019 Feb 25. Epub 2019 Feb 25.

1 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

Spinal cord injury (SCI) repair is one of the most desirable but extremely challenging clinical problems. Developing suitable animal models and validating the therapeutic interventions in these models is the prerequisite for SCI repair improvement. Non-human primates, closer to humans than other species, are considered to be ideal models for translating laboratory discoveries into human clinical trials. Read More

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http://dx.doi.org/10.1089/neu.2018.6078DOI Listing
February 2019
3 Reads
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The Association of Very Early Serum levels of S100B, GFAP, UCH-L1, and SBDP with Outcome in ProTECT III.

J Neurotrauma 2019 02 22. Epub 2019 Feb 22.

Emory University, Emergency Medicine , Emergency Medicine Research Center , 49 Jesse Hill Jr. Dr. , Atlanta, Georgia, United States , 30303 ;

Rapid risk-stratification of patients with acute traumatic brain injury (TBI) would inform management decisions and prognostication. The objective of this serum biomarker study (BIO-ProTECT) was to test the hypothesis that serum biomarkers of structural brain injury, measured at a single very early timepoint, add value beyond relevant clinical covariates when predicting unfavorable outcome 6-months after moderate-to-severe acute TBI. BIO-ProTECT utilized prospectively collected samples obtained from subjects with moderate-to-severe TBI enrolled in the ProTECT III clinical trial of progesterone. Read More

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http://dx.doi.org/10.1089/neu.2018.5809DOI Listing
February 2019
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Low-Dose Testosterone and Evoked Resistance Exercise after Spinal Cord Injury on Cardio-Metabolic Risk Factors: An Open-Label Randomized Clinical Trial.

J Neurotrauma 2019 Mar 28. Epub 2019 Mar 28.

3 Endocrinology Service, Hunter Holmes McGuire VA Medical Center, Richmond, Virginia.

The purpose of the work is to investigate the effects of low-dose testosterone replacement therapy (TRT) and evoked resistance training (RT) on body composition and metabolic variables after spinal cord injury (SCI). Twenty-two individuals with chronic motor complete SCI (ages 18-50 years) were randomly assigned to either TRT+RT (n = 11) or TRT (n = 11) for 16 weeks following a 4 -week delayed entry period. TRT+RT men underwent twice weekly progressive RT using electrical stimulation with ankle weights. Read More

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http://dx.doi.org/10.1089/neu.2018.6136DOI Listing
March 2019
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Testosterone Administration after Traumatic Brain Injury Reduces Mitochondrial Dysfunction and Neurodegeneration.

J Neurotrauma 2019 Apr 9. Epub 2019 Apr 9.

1 Laboratory of Neurotrauma and Biomarkers, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Traumatic brain injury (TBI) increases Ca influx into neurons and desynchronizes mitochondrial function leading to energy depletion and apoptosis. This process may be influenced by brain testosterone (TS) levels, which are known to decrease after TBI. We hypothesized that a TS-based therapy could preserve mitochondrial neuroenergetics after TBI, thereby reducing neurodegeneration. Read More

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http://dx.doi.org/10.1089/neu.2018.6266DOI Listing
April 2019
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Data Dissemination: Shortening the Long Tail of Traumatic Brain Injury Dark Data.

J Neurotrauma 2019 Mar 29. Epub 2019 Mar 29.

2 Weill Institutes for Neurosciences, Brain and Spinal Injury Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.

Translation of traumatic brain injury (TBI) research findings from bench to bedside involves aligning multi-species data across diverse data types including imaging and molecular biomarkers, histopathology, behavior, and functional outcomes. In this review we argue that TBI translation should be acknowledged for what it is: a problem of big data that can be addressed using modern data science approaches. We review the history of the term big data, tracing its origins in Internet technology as data that are "big" according to the "4Vs" of volume, velocity, variety, veracity and discuss how the term has transitioned into the mainstream of biomedical research. Read More

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http://dx.doi.org/10.1089/neu.2018.6192DOI Listing
March 2019
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Specific brain morphometric changes in spinal cord injury: a voxel-based meta-analysis of white and grey matter volume.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

105# jiefang roadJinan, Shandong, China , 250013 ;

We want to investigate degenerative changes of white matter volume (WMV) and grey matter volume (GMV) in individuals after a spinal cord injury (SCI). Published studies of whole-brain voxel-based morphometry (VBM) comparing SCI patients with controls published between 2006 and March 1st, 2018 were collected by searching PubMed, Web of Science, and EMBASE databases. Voxel-wise meta-analyses of GMV and WMV differences between SCI patients and controls were performed separately using seed-based d mapping. Read More

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http://dx.doi.org/10.1089/neu.2018.6205DOI Listing
February 2019
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Sex differences in traumatic brain injury: What we know and what we should know.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

University of Kansas Medical Center, Hoglund Brain Imaging Center , 3901 Rainbow Blvd. , Mail Stop 1052 , Kansas City, Kansas, United States , 66160 ;

There is growing recognition of the problem of male bias in neuroscience research, including in the field of traumatic brain injury (TBI) where fewer women than men are recruited to clinical trials and male rodents have predominantly been used as an experimental injury model. Despite TBI being a leading cause of mortality and disability worldwide, sex differences in the pathophysiology and recovery are poorly understood, limiting clinical care and successful drug development. Given growing interest in sex as a biological variable affecting injury outcomes and treatment efficacy, there is a clear need to summarize sex differences in TBI. Read More

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http://dx.doi.org/10.1089/neu.2018.6171DOI Listing
February 2019
2 Reads