27,338,764 results match your criteria Journal of Neuropsychology [Journal]

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[Consult Your Physician or Health Care Provider? Health and Legal Aspects Regarding the Use of Dietary Supplements Offered in the World Wide Web].

Sportverletz Sportschaden 2018 Dec 11;32(4):264-271. Epub 2018 Dec 11.

Hochschule für öffentliche Verwaltung und Finanzen Ludwigsburg.

Background:  In Germany, widespread use is made of dietary supplements (DS) to improve the individual health status, especially among patients diagnosed with certain conditions, elderly people and athletes. Legal aspects as well as health risks related to DS purchased via the internet are rarely analysed in Germany.

Purpose:  We aim to provide a review of the respective literature focusing on health risks, legal aspects und consumer information related to the internet retailing of DS. Read More

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December 2018
3 Reads

Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics.

Sportverletz Sportschaden 2018 Dec 11;32(4):243-250. Epub 2018 Dec 11.

Muscle Research Center Erlangen, Interdisciplinary Center for Muscle Research, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.

Delayed-onset muscle soreness (DOMS) is a type of ultrastructural muscle injury. The manifestation of DOMS is caused by eccentric or unfamiliar forms of exercise. Clinical signs include reduced force capacities, increased painful restriction of movement, stiffness, swelling, and dysfunction of adjacent joints. Read More

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December 2018

Diagnosis of A3 Pulley Injuries Using Ultrasound.

Sportverletz Sportschaden 2018 Dec 11;32(4):251-259. Epub 2018 Dec 11.

Department of Sportsmedicine, Department of Orthopedic and Trauma Surgery, Klinikum Bamberg, Bamberg, Germany.

Rationale And Objectives:  Pulley ruptures are the most common injuries in sport climbing. Ruptures of the A2 and A4 pulleys have been studied extensively, and ultrasound has proven to be a highly sensitive and specific tool for their diagnosis. However, the correct diagnosis of A3 pulley ruptures continues to be a challenge. Read More

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December 2018

Ski Mountaineering - Evaluation of a Sports Specific Performance Diagnosis.

Sportverletz Sportschaden 2018 Dec 11;32(4):233-242. Epub 2018 Dec 11.

SozialStiftung Bamberg, Sports Orthopedics, Bamberg.

Ski mountaineering (skimo) has recently gained popularity and established itself as a competition sport. It requires a specific training with a high hypoxic load. Although a variety of sport specific performance test protocols have been developed, a specific method for ski mountaineering (skimo) is pending. Read More

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December 2018
2 Reads

Danksagung an die Gutachter.

Authors:

Sportverletz Sportschaden 2018 Dec 11;32(4):207. Epub 2018 Dec 11.

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December 2018

[Endovascular Therapy of Splanchnic Artery Aneurysms: For Each and Every Aneurysm?]

Zentralbl Chir 2018 Dec 11. Epub 2018 Dec 11.

Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Deutschland.

True visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA) are located in the celiac trunk, the superior mesenteric artery and inferior mesenteric artery. In addition to surgical treatment, endovascular embolisation therapy of visceral aneurysms and pseudoaneurysms is an alternative interventional method that has developed precipitously over the last two decades and is considered a first-choice method in many centres. The procedure is characterised by a high technical success rate with a low complication rate. Read More

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December 2018

Endoscopic sleeve gastroplasty for severe obesity by full-thickness suturing using the GERDX device.

Endoscopy 2018 Dec 11. Epub 2018 Dec 11.

Internal Medicine I, Klinikum Ludwigsburg, Ludwigsburg Germany.

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December 2018
1 Read

Computed tomographic colonography with the step-clipping method detects a previously bleeding diverticulum.

Endoscopy 2018 Dec 11. Epub 2018 Dec 11.

Department of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.

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December 2018
1 Read

Endoscopic ultrasound-guided coil embolization and thrombin injection of a bleeding gastroduodenal artery pseudoaneurysm.

Endoscopy 2018 Dec 11. Epub 2018 Dec 11.

Department of Gastroenterology, Jaswant Rai Speciality Hospital, Meerut, India.

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December 2018
1 Read

Biliary cannulation technique with ultraslim endoscope for a patient with Billroth II gastrectomy.

Endoscopy 2018 Dec 11. Epub 2018 Dec 11.

Department of Gastroenterology, Okayama University Hospital, Okayama, Japan.

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December 2018
1 Read

Endoscopic lithotripsy for right intrahepatic bile duct stone through endoscopic ultrasound-guided hepaticogastrostomy.

Endoscopy 2018 Dec 11. Epub 2018 Dec 11.

Department of Gastroenterology, Kyoto Second Red Cross Hospital, Kyoto, Japan.

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December 2018

[Use of Negative Pressure Wound Therapy with Instillation and Dwell Time for Wound Treatment - Results of an Expert Consensus Conference].

Zentralbl Chir 2018 Dec 11;143(6):609-616. Epub 2018 Dec 11.

Unfallchirurgie, Bundeswehrkrankenhaus Berlin, Deutschland.

Rinsing wounds with wound cleansing solutions has long been a recognised cornerstone in wound management as a means of removing cell debris and surface pathogens in wound exudates. In combination with surgical debridement and topical negative pressure wound therapy (NPWT), this can facilitate the intended progression from the inflammatory to the proliferative phase of wound healing. Procedures of topical negative pressure wound therapy with instillation and a defined exposure/dwell-time of topical solutions under cyclic compression and decompression with foam dressings (NPWTi-d) can remove cellular remnants and debris that may inhibit the healing process. Read More

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December 2018
1 Read

Editorial.

Authors:
Jörg C Kalff

Zentralbl Chir 2018 Dec 11;143(6):576. Epub 2018 Dec 11.

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December 2018

Frühe Mortalität nach Lebertransplantation.

Authors:

Zentralbl Chir 2018 Dec 11;143(6):567. Epub 2018 Dec 11.

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December 2018

Risikobewertung bei Patienten mit ventraler Hernie und Vorbehandlung.

Authors:

Zentralbl Chir 2018 Dec 11;143(6):566. Epub 2018 Dec 11.

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December 2018

Variabilität bei Bluttransfusionen nach Pankreatikoduodenektomie.

Authors:

Zentralbl Chir 2018 Dec 11;143(6):565-566. Epub 2018 Dec 11.

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December 2018

Zeitpunkt einer Nierenersatztherapie bei Patienten mit akutem Nierenversagen und Sepsis.

Authors:

Zentralbl Chir 2018 Dec 11;143(6):565. Epub 2018 Dec 11.

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December 2018

Klinische Umsetzung und Konsequenzen aus der S3-Leitlinie „Ösophaguskarzinom“.

Zentralbl Chir 2018 Dec 11;143(6):561-564. Epub 2018 Dec 11.

Klinik für Allgemein-, Viszeral- und Tumorchirurgie, Universitätsklinik Köln.

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December 2018

Dank an die Gutachter.

Authors:

Zentralbl Chir 2018 Dec 11;143(6):554-555. Epub 2018 Dec 11.

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December 2018

[Value of sialendoscopy in German ENT-hospitals in 2016].

Laryngorhinootologie 2018 Dec 11. Epub 2018 Dec 11.

Universitatsklinikum Giessen und Marburg Standort Giessen HNO.

Objective: In 2009 a nationwide survey revealed that only 24 % of the German ENT-hospitals performed sialendoscopy. In 2016 the survey was repeated to reevaluate the actual ranking of sialendoscopy in Germany.

Material Und Methods: Again, the same questionnaire as in 2009 was sent to all German ENT-hospitals. Read More

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December 2018
1 Read

Systemic Arterial Hypertension in Childhood: A Challenge Related to the Increasing Survival of Very Low Birth Weight Preterm Infants.

Am J Perinatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objective:  To verify the prevalence of systemic arterial hypertension (SAH) and to identify possible early predictors of SAH at ages 2 and 4 years in very low birth weight (VLBW) infants.

Study Design:  This is a prospective cohort study including inborn children with birth weight (BW) <1,500 g. Arterial blood pressure measurements were performed at 2 and 4 years. Read More

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December 2018

[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018

[Coercion and aggression in psychiatry: the individual psychological dimension of aggressive and coercive acts by therapists].

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik für Psychiatrie, Psychotherapie und Präventivmedizin, LWL-Universitätsklinikum der Ruhr-Universität Bochum.

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December 2018

Psychiatric comorbidy in Ullrich-Turner syndrome.

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Ruhr-Universität Bochum, Psychiatrie.

Objective: Ullrich-Turner Syndrome (UTS; Turner Syndrome (TS)) is a X-chromosomal disorder, which is characterized by a variety and heterogenous clinical conditions. Although it is not typically associated with neuropsychiatric disorders, several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link.

Methods: Based on the case representation of woman with TS and co-occurrent schizoaffective disorder we discuss possible relationships and current literature. Read More

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December 2018
2 Reads

Case Report: Unexpected Benefit of Echocardiography in Childhood Polyarteritis Nodosa.

Klin Padiatr 2018 Dec 11. Epub 2018 Dec 11.

General University Hospital, Paediatric Rheumatology and Autoinflammatory Diseases Unit, Praha, Czech Republic.

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December 2018

Acknowledgement for Reviewers.

Authors:

Drug Res (Stuttg) 2018 Dec 11;68(12):665-668. Epub 2018 Dec 11.

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December 2018
1 Read

[Acute Motor Failure of the N. Peroneus Profundus Caused by a Cystic Tibiofibular Joint].

Z Orthop Unfall 2018 Dec 11. Epub 2018 Dec 11.

Orthopädie und Traumatologie, Bürgerspital Solothurn, Solothurn, Schweiz.

A ganglion cyst is rarely the cause of peripheral nerve compression. In the lower extremity, it is important to distinguish clinically the symptoms from a radiculopathy. In the literature, neural damage of the peroneal nerve due to a ganglion cyst has been described. Read More

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December 2018

Characteristics of interactions at protein segments without non-local intramolecular contacts in the Protein Data Bank.

PLoS One 2018 11;13(12):e0205052. Epub 2018 Dec 11.

School of Life Science and Technology, Tokyo Institute of Technology, Nagatsuda-cho, Midori-ku, Yokohama, Kanagawa, Japan.

The principle of three-dimensional protein structure formation is a long-standing conundrum in structural biology. A globular domain of a soluble protein is formed by a network of atomic contacts among amino acid residues, but regions without intramolecular non-local contacts are often observed in the protein structure, especially in loop, linker, and peripheral segments with secondary structures. Although these regions can play key roles for protein function as interfaces for intermolecular interactions, their nature remains unclear. Read More

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December 2018
3 Reads

Adherence to Subcutaneous Allergen Immunotherapy in Southeast Turkey: A Real-Life Study.

Authors:
Tugba S Tat

Med Sci Monit 2018 Dec 11;24:8977-8983. Epub 2018 Dec 11.

Department of Allergy and Immunology, Dr. Ersin Arslan Education and Research Hospital, Gaziantep, Turkey.

BACKGROUND Subcutaneous immunotherapy (SCIT) in allergic rhinitis (AR) and asthma is a very effective treatment, but adherence is still a serious problem. Studies addressing real-life adherence to SCIT are rare in the literature. The aim of this study was to evaluate the adherence to SCIT in AR and asthma. Read More

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December 2018

Electrochemotherapy in the Treatment of Breast Cancer Metastasis to the Skin and Subcutaneous Tissue - Multicenter Experience.

Oncol Res Treat 2018 Dec 12;42(1-2). Epub 2018 Dec 12.

Introduction: Breast cancer is responsible for more than 50% of cutaneous metastases. One of the treatment options is electrochemotherapy (ECT). It is an effective method of local tumor ablation through the application of electroporation. Read More

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December 2018
1 Read

Palliative Care in Patients with Hematological Malignancies.

Authors:
Karin Oechsle

Oncol Res Treat 2018 Dec 12;42(1-2). Epub 2018 Dec 12.

Patients with hematologic malignancies (HM) nowadays rarely receive palliative or hospice care, and studies on potential effects of integrated palliative care are rare. This narrative review provides a comprehensive overview on their current end-of-life care, first data on integrated specialist palliative care (SPC) and potential barriers. Symptom burden and distress in patients with HM seem to be comparable to other cancer patients, but their performance status and specific symptoms are even worse. Read More

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December 2018

Effects of Light Treatment on Sleep, Cognition, Mood, and Behavior in Alzheimer's Disease: A Systematic Review.

Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):371-384. Epub 2018 Dec 11.

Department of Biomedical and NeuroMotor Sciences, Functional MR Unit, University of Bologna, Bologna,

Background: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect. Read More

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December 2018

Patient Perspective in Obesity Surgery: Goals for Weight Loss and Improvement of Body Shape in a Prospective Cohort Study.

Obes Facts 2018 Dec 11;11(6):466-474. Epub 2018 Dec 11.

Department of General and Visceral Surgery, Hospital Mittelbaden, Baden-Baden,

Objective: Obesity surgery provides sustainable weight loss, improvement of comorbidities, and improved quality of life (QOL). There is few evidence on the patient perspective and goals. This study compared expected and achieved weight loss, body shape, and QOL. Read More

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December 2018
1 Read

Nonalcoholic-Fatty-Liver-Disease and Nonalcoholic Steatohepatitis: Successful Development of Pharmacological Treatment Will Depend on Translational Research.

Digestion 2018 Dec 7:1-7. Epub 2018 Dec 7.

Background: Nonalcoholic-fatty-liver-disease/nonalcoholic steatohepatitis (NAFLD/NASH) is expected to become the leading liver disease worldwide. Typical liver-related complications are fibrosis, cirrhosis, and the development of hepatocellular cancer (HCC) with the need for liver transplantation. Up to now there is no approved pharmacotherapy. Read More

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December 2018

Insulin Pump Therapy - Influence on Body Fat Redistribution, Skeletal Muscle Mass and Ghrelin, Leptin Changes in T1D Patients.

Obes Facts 2018 Dec 11;11(6):454-464. Epub 2018 Dec 11.

Clinic of Internal Medicine, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Bratislava, Slovakia.

Background: To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII).

Methods: 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. Read More

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December 2018
6 Reads

Efficacy and Safety of Amrubicin in Non-Small-Cell Lung Cancer Patients Beyond Third-Line Therapy.

Oncol Res Treat 2018 Dec 12;42(1-2). Epub 2018 Dec 12.

Background: There are no standard cytotoxic treatments for non-small-cell lung cancer (NSCLC) patients beyond third-line therapy. The purpose of this study was to evaluate the efficacy and safety of amrubicin in pretreated NSCLC patients.

Methods: The records of NSCLC patients who received amrubicin monotherapy as a third or later line of chemotherapy at Shizuoka General Hospital between April 2007 and March 2015 were retrospectively reviewed. Read More

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December 2018

Gene Expression Profiles of Tumor Necrosis Factor-α and Endothelin-1 in Obstructive Sleep Apnea.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):16-23. Epub 2018 Dec 11.

Department of Otolaryngology and Head and Neck Surgery, Wakayama University Hospital, Wakayama, Japan.

Background/aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA).

Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). Read More

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December 2018
2 Reads

The Value of Unilateral CIs, CI-CROS and Bilateral CIs, with and without Beamformer Microphones, for Speech Understanding in a Simulation of a Restaurant Environment.

Audiol Neurootol 2018 Dec 11;23(5):270-276. Epub 2018 Dec 11.

Advanced Bionics, Valencia, California, USA.

Objective: Our primary aim was to determine, in a simulation of a crowded restaurant, the value to speech understanding of (i) a unilateral cochlear implant (CI), (ii) a CI plus CROS (contralateral routing of signals) aid system and (iii) bilateral CIs when tested with and without beamforming microphones.

Design: The listeners were 7 CI listeners who had used bilateral CIs for an average of 9 years. The listeners were tested with three device configurations (bilateral CI, unilateral CI + CROS, and unilateral CI), two signal processing conditions (without and with beamformers) and with speech either from +90°, -90°, or from the front. Read More

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December 2018

The Effectiveness of a Virtual Reality-Based Tai Chi Exercise on Cognitive and Physical Function in Older Adults with Cognitive Impairment.

Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):358-370. Epub 2018 Dec 11.

Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Tai Chi (TC) is a Chinese mind-body exercise with proven physical and psychological benefits. A modified TC via virtual reality (VR) may be suitable for the elderly owing to the immediate guidance and feedback regarding movement accuracy. This study explored the cognitive and physical effects of a VR-based TC (VRTC) exercise program on older adults with cognitive impairment (CI). Read More

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December 2018
1 Read

The Efficacy of Concurrent or Sequential Intravenous and Intratympanic Steroid for Idiopathic Sudden Sensorineural Hearing Loss.

Audiol Neurootol 2018 Dec 11;23(5):277-284. Epub 2018 Dec 11.

Department of Otorhinolaryngology - Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.

Objective: The purpose of this retrospective study was to investigate the difference in treatment outcomes for patients with idiopathic sudden sensorineural hearing loss (SSNHL) undergoing concurrent or sequential intravenous (IV) and intratympanic (IT) steroid therapies.

Methods: Patients with idiopathic SSNHL admitted to Taipei Veterans Hospital from August 2011 to August 2012 were enrolled. Patients were treated with both IV dexamethasone 5 mg b. Read More

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December 2018

The Influence of Sleep Apnea on 24-hour and Nocturnal ECG and Blood Pressure Parameters in Patients with Acute Heart Failure.

Med Princ Pract 2018 Dec 11. Epub 2018 Dec 11.

Objective: To investigate the influence of sleep apnea on ECG and blood pressure monitoring parameters in patients with acute heart failure (AHF).

Methods: 51 hospitalized patients with AHF (13 women, 38 men, mean age 60.8 years) underwent 24-hour combined monitoring of ECG and blood pressure and sleep apnea testing before discharge. Read More

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December 2018
1 Read

Alterations of Renal Epithelial Glucose and Uric Acid Transporters in Fructose Induced Metabolic Syndrome.

Kidney Blood Press Res 2018 Dec 7;43(6):1822-1831. Epub 2018 Dec 7.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung,

Background/aims: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric acid transporters in animals with metabolic syndrome. Read More

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December 2018

Predictive Value of Age-Bilirubin-International Normalized Ratio-Creatinine Score in Short-Term Survival of Acute-on-Chronic Hepatitis B Liver Failure.

Cell Physiol Biochem 2018 11;51(5):2484-2495. Epub 2018 Dec 11.

Department of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.

Background/aims: The age-bilirubin-international normalized ratio-creatinine (ABIC) score, which is a predictive model commonly used for alcoholic hepatitis, has not yet been studied in acute-on-chronic hepatitis B liver failure (HBV-ACLF). We aimed to investigate the predictive value of the ABIC score in patients with HBV-ACLF.

Methods: This retrospective study involved 398 patients diagnosed with HBV-ACLF, who were divided into a training cohort of 305 patients and a validation cohort of 93 patients. Read More

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December 2018

Stromal Cell-Derived CCL20 Promotes Tumor Progression and Osteolysis in Giant Cell Tumor of Bone.

Cell Physiol Biochem 2018 11;51(5):2472-2483. Epub 2018 Dec 11.

Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background/aims: Giant cell tumor of bone (GCTB), one of the most common primary bone tumors, leads to extensive bone destruction. However, the mechanisms underlying GCTB progression remain elusive and prognostic factors and treatment targets are required. In the current study, we explored the function of the chemokine family member CCL20 in GCTB progression. Read More

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December 2018
1 Read

Protective Mechanism of Adipose-Derived Stem Cells in Remodelling of the Skin Stem Cell Niche During Photoaging.

Cell Physiol Biochem 2018 11;51(5):2456-2471. Epub 2018 Dec 11.

Background/aims: Skin photoaging is primarily caused by the functional attrition of skin stem cells. The skin stem cell niche plays an important role in maintaining stem cell survival and behaviour. In our study, we hypothesized that UVB irradiation induces skin photoaging by changing skin stem cell niches and that transferred adipose-derived stem cells (ADSCs) can remodel the niches by affecting the BMP signalling pathway and transdifferentiating into skin stem cells. Read More

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December 2018
1 Read

A Novel Variant of the FZD4 Gene in a Chinese Family Causes Autosomal Dominant Familial Exudative Vitreoretinopathy.

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

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December 2018
1 Read

PGK1 is a Potential Survival Biomarker and Invasion Promoter by Regulating the HIF-1α-Mediated Epithelial-Mesenchymal Transition Process in Breast Cancer.

Cell Physiol Biochem 2018 11;51(5):2434-2444. Epub 2018 Dec 11.

The Clinical Medical Testing Laboratory, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China.

Background/aims: Glycolysis, a multi-step enzymatic reaction, is considered to be the root of cancer development and progression. The aim of this study is to figure out which glycolysis enzyme participates in the progression of breast cancer and its possible mechanisms.

Materials: We firstly screened out PGK1 by performing an RT-PCR array of glycolysis-related genes in three paired breast cancer samples, and further investigated PGK1 using TCGA and our own database. Read More

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December 2018

Sodium Fluoride Arrests Renal G2/M Phase Cell-Cycle Progression by Activating ATM-Chk2-P53/Cdc25C Signaling Pathway in Mice.

Cell Physiol Biochem 2018 11;51(5):2421-2433. Epub 2018 Dec 11.

College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, China.

Background/aims: Excessive fluoride intake can induce cytotoxicity, DNA damage and cell-cycle changes in many tissues and organs, including the kidney. However, the underlying molecular mechanisms of fluoride-induced renal cell-cycle changes are not well understood at present. In this study, we used a mouse model to investigate how sodium fluoride (NaF) induces cell-cycle changes in renal cells. Read More

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December 2018

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism.

Cell Physiol Biochem 2018 11;51(5):2397-2420. Epub 2018 Dec 11.

Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing,

Background/aims: Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, and an increased accumulation of LDs in the liver is closely linked to hepatic steatosis. Our previous studies suggested that resveratrol (RSV) supplement could improve hepatic steatosis, but the underlying mechanism, particularly which related to LD accumulation, has not yet been elucidated.

Methods: A high-fat diet (HFD) and palmitic acid were used to induce hepatic steatosis in mouse liver and hepatocytes, respectively. Read More

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December 2018
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