40,073 results match your criteria Journal of Neuropathic Pain & Symptom Palliation [Journal]


Lack of correlation between the activity of the mesolimbic dopaminergic system and the rewarding properties of pregabalin in mouse.

Psychopharmacology (Berl) 2019 Mar 16. Epub 2019 Mar 16.

Pharmacoepidemiology Research Unit, INSERM-Université Toulouse 3, UMR 1027, 31000, Toulouse, France.

Rationale: Pregabalin is a psychoactive drug indicated in the treatment of epilepsy, neuropathic pain, and generalized anxiety disorders. Pregabalin acts on different neurotransmission systems by inactivating the alpha2-delta subunit of voltage-gated calcium channels. In light of this pharmacological property, the hypothesis has been raised that pregabalin may regulate the mesolimbic dopamine pathway and thereby display a potential for misuse or abuse as recently observed in humans. Read More

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http://dx.doi.org/10.1007/s00213-019-05198-zDOI Listing

Role of the P2X4 receptor in neuropathic pain.

Authors:
Kazuhide Inoue

Curr Opin Pharmacol 2019 Mar 14;47:33-39. Epub 2019 Mar 14.

Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address:

Neuropathic pain is the most important type of chronic pain because it is refractory to available medications. Neuropathic pain occurs after peripheral nerve injury (PNI) or nerve damage by various reasons. In recent decades, a growing body of evidence shows that spinal microglia and P2X4 receptor (P2X4R), a subtype of ionotropic ATP receptors, play a principal role in evoking this pain. Read More

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http://dx.doi.org/10.1016/j.coph.2019.02.001DOI Listing

Time course of pain response and toxicity after whole-nerve-encompassing LINAC-based stereotactic radiosurgery for trigeminal neuralgia-a prospective observational study.

Strahlenther Onkol 2019 Mar 15. Epub 2019 Mar 15.

Department of Radiation Oncology, Friedrich-Alexander-University Erlangen-Nuremberg, Universitaetsstraße 27, 91054, Erlangen, Germany.

Purpose: To prospectively evaluate the time course of pain response and toxicity after linear accelerator-based whole-nerve-encompassing radiosurgery (LINAC-SRS) using a uniform treatment schedule for dosing and target volume definition in patients with refractory trigeminal neuralgia.

Methods: From December 2012 to December 2016, 21 patients were treated using a standardized protocol. Patients received LINAC-SRS with 70 Gy to the cisternal portion while aiming for the 90% isodose to fully envelope the nerve in one cross-sectional plane. Read More

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http://dx.doi.org/10.1007/s00066-019-01450-9DOI Listing

D2-like receptor agonist synergizes the μ-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat.

Eur J Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

Laboratorio de Fisiología Celular, Dirección de Investigaciones en Neurociencias. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México. Electronic address:

Opioids are potent analgesic drugs, but their use has been limited due to their side effects. Antinociceptive effects of D2-like receptor agonists such as quinpirole have been shown at the spinal cord level; however, their efficacy is not as high as that of opioids. Dopaminergic agonists are long-prescribed and well-tolerated drugs that have been useful to treat clinically and experimentally painful conditions. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.020DOI Listing

'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency.

Mar Drugs 2019 Mar 14;17(3). Epub 2019 Mar 14.

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.

Integrated venomics techniques have shown that variable processing of conotoxins from resulted in a dramatic expansion in the number of expressed conotoxins. One conotoxin from , the χ-conotoxin MrIA, is a selective inhibitor of human norepinephrine transporters (hNET) and therefore a drug candidate for attenuating chronic neuropathic pain. It has been found that "messy" processing of the MrIA transcripts results in the expression of MrIA analogs with different truncations of the pro-peptide that contains portions of the MrIA molecule. Read More

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http://dx.doi.org/10.3390/md17030165DOI Listing

Silencing of lncRNA PKIA-AS1 Attenuates Spinal Nerve Ligation-Induced Neuropathic Pain Through Epigenetic Downregulation of CDK6 Expression.

Front Cell Neurosci 2019 20;13:50. Epub 2019 Feb 20.

Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Xiangya Hospital, Central South University, Changsha, China.

Neuropathic pain (NP) is among the most intractable comorbidities of spinal cord injury. Dysregulation of non-coding RNAs has also been implicated in the development of neuropathic pain. Here, we identified a novel lncRNA, PKIA-AS1, by using lncRNA array analysis in spinal cord tissue of spinal nerve ligation (SNL) model rats, and investigated the role of PKIA-AS1 in SNL-mediated neuropathic pain. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00050
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http://dx.doi.org/10.3389/fncel.2019.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401634PMC
February 2019
2 Reads

Upregulation of interleukin-6 on Ca3.2 T-type calcium channels in dorsal root ganglion neurons contributes to neuropathic pain in rats with spinal nerve ligation.

Exp Neurol 2019 Mar 11. Epub 2019 Mar 11.

Neuroscience Research Institute, Peking University, Beijing 100083, China; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100083, China. Electronic address:

The T-type calcium channels Ca3.2, one of the low voltage-activated (LVA) calcium channels, have been found to play important roles in the neuronal excitability. Recently, we and others have demonstrated that accumulation of Ca3. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.03.005DOI Listing

Special issue : Neuronal protein mobility KCC2 membrane diffusion tunes neuronal chloride homeostasis.

Neuropharmacology 2019 Mar 11. Epub 2019 Mar 11.

INSERM UMR-S 1270, 75005, Paris, France; Sorbonne Université, 75005, Paris, France; Institut du Fer à Moulin, 75005, Paris, France. Electronic address:

Neuronal Cl homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K-Cl cotransporter KCC2 and the Na-K-Cl cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, neuropathic pain, schizophrenia and autism are associated with altered neuronal chloride (Cl) homeostasis. A current view is that the accumulation of intracellular Cl in neurons as a result of KCC2 down-regulation and/or NKCC1 up-regulation may weaken inhibitory GABA signaling and thereby promote the development of pathological activities. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.03.014DOI Listing

CRMP2-derived peptide ST2-104 (R9-CBD3) protects SH-SY5Y neuroblastoma cells against Aβ-induced neurotoxicity by inhibiting the pCRMP2/NMDAR2B signaling pathway.

Chem Biol Interact 2019 Mar 11. Epub 2019 Mar 11.

Department of Neurology and Neuroscience Center, The First Hospital, Jilin University, Changchun, Jilin 130021, PR China. Electronic address:

Collapsin response mediator protein 2 (CRMP2),by regulating voltage-gated calcium channel activity, is a crucial regulator of neuronal excitability. Hyperphosphorylation of CRMP2 has been reported in brains of Alzheimer's disease (AD) patients and other neurodegenerative diseases. CRMP2 acting on N-methyl-d-aspartate receptors (NMDARs) may contribute to AD pathology. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.03.005DOI Listing

Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors-dependent manner.

J Pharmacol Sci 2019 Feb 27. Epub 2019 Feb 27.

Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait.

Neuropathic pain sometimes occurs during chemotherapy with paclitaxel or HIV/AIDS antiretroviral therapy with nucleoside reverse transcriptase inhibitors (NRTIs). We previously reported that coadministration of indomethacin plus minocycline (IPM) was antihyperalgesic in a cannabinoid type 1 (CB1) receptor-dependent manner in a mouse model of paclitaxel-induced neuropathic pain. We evaluated if IPM combination has antihyperalgesic and antiallodynic activities in animal models of paclitaxel or NRTI (ddC, zalcitabine)-induced neuropathic pain, and whether antagonists of CB1, CB2 receptors or G protein-coupled receptor 55 (GPR55) can inhibit these activities of IPM. Read More

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http://dx.doi.org/10.1016/j.jphs.2019.02.007DOI Listing
February 2019

Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain.

Bioorg Med Chem Lett 2019 Mar 11. Epub 2019 Mar 11.

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research, New Delhi, India. Electronic address:

Neuropathic pain is a debilitating form of treatment-resistant chronic pain caused by damage to the nervous system. Cannabinoids have been known for suppressing neuropathic pain by modulating the endo cannabinoid system. Since the canonical Wnt/β-catenin signaling has recently been implicated in pain sensation, we investigated the impact of major cannabinoids (1-6) from the leaves of Cannabis sativa and an epoxy derivative of compound 2, here upon referred to as 2a, on modulating Wnt/β-catenin signaling pathway. Read More

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http://dx.doi.org/10.1016/j.bmcl.2019.03.013DOI Listing

Kappa Opioid Signaling in the Right Central Amygdala Causes Hindpaw Specific Loss of Diffuse Noxious Inhibitory Controls (DNIC) in Experimental Neuropathic Pain.

Pain 2019 Mar 8. Epub 2019 Mar 8.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London,. United Kingdom.

Diffuse noxious inhibitory controls (DNIC) is a pain inhibits pain phenomenon demonstrated in humans and animals. DNIC is diminished in many chronic pain states, including neuropathic pain. The efficiency of DNIC has been suggested to prospectively predict both the likelihood of pain chronification and treatment response. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001553DOI Listing

Characterization of traumatic spinal cord injury model in relation to neuropathic pain in the rat.

Somatosens Mot Res 2019 Mar 14:1-10. Epub 2019 Mar 14.

e Department of Neurosurgery , Eberhard-Karls University , Tuebingen , Germany.

Purpose/aim: Neuropathic pain following spinal cord injury (SCI) has a tremendous impact on patient's quality of life, and frequently is the most limiting aspect of the disease. In view of the severity of this condition and the absence of effective treatments, the establishment of a reliable animal model that reproduces neuropathic pain after injury is crucial for a better understanding of the pathophysiology and for the development of new therapeutic strategies. Thus, the objective of the present study was to standardize the traumatic SCI model in relation to neuropathic pain. Read More

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http://dx.doi.org/10.1080/08990220.2018.1563537DOI Listing

[Migraine, trigeminal neuralgia and cluster headache].

Authors:
Caroline Roos

Rev Prat 2018 Nov;68(9):e339-e350

Neurologue, responsable du centre d'urgence des céphalées, hôpital Lariboisière, 75010 Paris, France.

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November 2018

Attenuating effect of Portulaca oleracea extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative and anti-inflammatory properties.

CNS Neurol Disord Drug Targets 2019 Mar 13. Epub 2019 Mar 13.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad. Iran.

Neuropathic pain responds poorly to drug treatments. The present study investigated the therapeutic effect of Portulaca oleracea, in chronic constriction injury (CCI)-induced neuropathic pain in rats. Neuropathic pain was performed by putting four loose ligatures around the sciatic nerve. Read More

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http://www.eurekaselect.com/170714/article
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http://dx.doi.org/10.2174/1871527318666190314110528DOI Listing
March 2019
8 Reads

[EXPRESS] Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model.

Mol Pain 2019 Mar 14:1744806919841196. Epub 2019 Mar 14.

Nihon University School of Dentistry.

High frequency spontaneous activity in injured primary afferents has been proposed as a pathological mechanism of neuropathic pain following nerve injury. Although spinal infusion of glial cell line-derived neurotrophic factor (GDNF) reduces the activity of injured myelinated A-fiber neurons after 5th lumbar (L5) spinal nerve ligation (SNL) in rats, the implicated molecular mechanism remains undetermined. The fast-inactivating transient A-type potassium current (IA) is an important determinant of neuronal excitability, and five voltage-gated potassium channel (Kv) alpha-subunits, Kv1. Read More

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http://journals.sagepub.com/doi/10.1177/1744806919841196
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http://dx.doi.org/10.1177/1744806919841196DOI Listing
March 2019
1 Read

Regional Catheters for Outpatient Surgery-a Comprehensive Review.

Curr Pain Headache Rep 2019 Mar 14;23(4):24. Epub 2019 Mar 14.

Department of Anesthesiology, Louisiana State University Health Science Center, New Orleans, LA, USA.

Purpose Of Review: This review summarizes and discusses the history of continuous catheter blockade (CCB), its current applications, clinical considerations, economic benefits, potential complications, patient education, and best practice techniques.

Recent Findings: Regional catheters for outpatient surgery have greatly impacted acute post-operative pain management and recovery. Prior to development, options for acute pain management were limited to the use of opioid pain medications, NSAIDS, neuropathic agents, and the like as local anesthetic duration of action is limited to 4-8 h. Read More

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http://link.springer.com/10.1007/s11916-019-0762-4
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http://dx.doi.org/10.1007/s11916-019-0762-4DOI Listing
March 2019
1 Read

Ultrasound-guided Erector Spinae Plane Block: Indications, Complications, and Effects on Acute and Chronic Pain Based on a Single-center Experience.

Cureus 2019 Jan 2;11(1):e3815. Epub 2019 Jan 2.

Pediatric Surgery, Maltepe University Faculty of Medicine, Istanbul, TUR.

Introduction: Erector spinae plane block (ESPB) is a novel regional anesthesia technique used in postoperative pain and chronic neuropathic pain of the thoracoabdominal region. There are no previously published large case series. This retrospective review aimed to report the indications, levels of block, success of block and complications, and also to evaluate the effect of ESPB on postoperative/chronic pain. Read More

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http://dx.doi.org/10.7759/cureus.3815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402723PMC
January 2019

Response to Transforaminal Epidural Block as a Useful Predictive Factor of Postherpetic Neuralgia.

J Clin Med 2019 Mar 7;8(3). Epub 2019 Mar 7.

Department of Anesthesiology and Pain Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 34943, Korea.

Despite the high frequency of nerve blocks in the acute phase of herpes zoster, factors associated with intervention, such as response to epidural block, have not been analyzed as predictive factors of postherpetic neuralgia (PHN). To determine the predictive factors of progression to PHN in the presence of interventions, we analyzed the medical records of 145 patients who underwent transforaminal epidural injection (TFEI) in the acute phase of herpes zoster. A total volume of 5 mL (a mixture of 0. Read More

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http://dx.doi.org/10.3390/jcm8030323DOI Listing

β-Caryophyllene, a Natural Sesquiterpene, Attenuates Neuropathic Pain and Depressive-Like Behavior in Experimental Diabetic Mice.

J Med Food 2019 Mar 13. Epub 2019 Mar 13.

1 Laboratory of Research and Pharmaceutical Development, University of Guadalajara, Guadalajara, Mexico.

Neuropathic pain (NP) is associated with chronic hyperglycemia and emotional disorders such as depression in diabetic patients, complicating the course of treatment. Drugs currently used to treat NP have undesirable side effects, so research on other natural sources has been required. β-caryophyllene (BCP), a natural sesquiterpene found in some food condiments and considered an agonist to cannabinoid receptor type 2, could have potential therapeutic effects to treat conditions such as NP and emotional disorders. Read More

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http://dx.doi.org/10.1089/jmf.2018.0157DOI Listing
March 2019
1 Read

Gabapentin versus Transdermal Fentanyl Matrix for the Alleviation of Chronic Neuropathic Pain of Radicular Origin: A Randomized Blind Multicentered Parallel-Group Noninferiority Trial.

Pain Res Manag 2019 4;2019:4905013. Epub 2019 Feb 4.

Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

A number of studies have been published proposing various approaches to the treatment of neuropathic pain; however, to our knowledge, no attempts have been made to compare gabapentin and fentanyl in patients with lumbar radiculopathy. We evaluated the relative efficacy and safety of fentanyl matrix and gabapentin for the treatment of chronic neuropathic pain of radicular origin. The study was designed as a randomized blind multicentered parallel-group noninferiority trial. Read More

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http://dx.doi.org/10.1155/2019/4905013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378801PMC
February 2019

Chronic localized back pain due to entrapment of cutaneous branches of posterior rami of the thoracic nerves (POCNES): a case series on diagnosis and management.

J Pain Res 2019 19;12:715-723. Epub 2019 Feb 19.

SolviMáx, Center of Expertise for ACNES, Center of Excellence for Chronic Abdominal Wall and Groin Pain, Department of Surgery, Máxima Medical Center, Veldhoven, The Netherlands,

Introduction And Aim: Chronic back pain (CBP) may be caused by a variety of conditions including dysfunctional muscles, ligaments or intervertebral discs, improper movement of vertebral column joints, or nerve root compression. Recently, CBP was treated successfully in a patient having an entrapment of cutaneous branches of the posterior rami of the thoracic nerves, termed posterior cutaneous nerve entrapment syndrome (POCNES). Our aim is to describe clinical presentation, differential diagnosis, and management of patients with such a neuropathic pain syndrome. Read More

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http://dx.doi.org/10.2147/JPR.S178492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388752PMC
February 2019

TRPV1 channel contributes to remifentanil-induced postoperative hyperalgesia via regulation of NMDA receptor trafficking in dorsal root ganglion.

J Pain Res 2019 15;12:667-677. Epub 2019 Feb 15.

Tianjin Research Institute of Anesthesiology, Tianjin, China,

Background: Remifentanil is widely used in general anesthesia due to its reliability and rapid onset. However, remifentanil-induced postoperative hyperalgesia might be a challenge nowadays. Accumulating evidence suggests that the transient receptor potential vanilloid 1 (TRPV1) was involved in the development of neuropathic pain and hyperalgesia. Read More

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http://dx.doi.org/10.2147/JPR.S186591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388729PMC
February 2019

Paresthesia-Free Dorsal Root Ganglion Stimulation: An ACCURATE Study Sub-Analysis.

Neuromodulation 2019 Mar 12. Epub 2019 Mar 12.

Marcus Neuroscience Institute, Boca Raton, FL, USA.

Introduction: ACCURATE, a randomized controlled trial comparing dorsal root ganglion (DRG) stimulation to spinal cord stimulation, showed that DRG stimulation is a safe and effective therapy in individuals with lower extremity chronic pain due to complex regional pain syndrome (CRPS) type I or II. Investigators noted that DRG stimulation programming could be adjusted to minimize, or eliminate, the feeling of paresthesia while maintaining adequate pain relief. The present study explores treatment outcomes for DRG subjects who were paresthesia-free vs. Read More

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http://doi.wiley.com/10.1111/ner.12942
Publisher Site
http://dx.doi.org/10.1111/ner.12942DOI Listing
March 2019
1 Read

Tapentadol in an Experimental Animal Model of Acute Orofacial Pain.

Authors:

Neuro Endocrinol Lett 2019 Feb 12;39(7):496-500. Epub 2019 Feb 12.

Objective: Tapentadol exhibits a synergistic dual effect effect (MOR / NRI) -agonist effect on noradrena-line reuptake inhibition (NRI). Tapentadol is effective on pain with neuropathic characteristics, therefore we decided to use it in an experimental model of acute orofacial pain.

Methods: The Orofacial Stimulation Test, developed by Ugo Basile, measures hypersensitivity to thermal or mechanical stimulation of the trigeminal area. Read More

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February 2019

EAN guideline on trigeminal neuralgia.

Eur J Neurol 2019 Mar 12. Epub 2019 Mar 12.

Department of Human Neuroscience, Sapienza University, viale Università 30, 00185, Rome, Italy.

Background: Trigeminal neuralgia (TN) is an extremely painful condition, which can be difficult to diagnose and treat. In Europe, TN-patients are managed by many different specialities. Therefore, there is a great need for comprehensive European guidelines for management of TN. Read More

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http://dx.doi.org/10.1111/ene.13950DOI Listing
March 2019
1 Read

A case of trigeminal neuralgia caused by both duplicated superior cerebellar arteries.

Neurol India 2019 Jan-Feb;67(1):276-277

Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama, Japan.

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http://dx.doi.org/10.4103/0028-3886.253640DOI Listing

Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats.

Neurochem Res 2019 Mar 11. Epub 2019 Mar 11.

Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, 226001, China.

Neuropathic pain (NP) has complicated pathogenesis as it mainly involves a lesion or dysfunction of the somatosensory nervous system and its clinical treatment remains challenging. Chronic constriction injury (CCI) model is a widely used neuropathic pain model and involved in mechanisms including both nerve inflammatory and injury. Cytokines and their receptors play essential roles in the occurrence and persistence of neuropathic pain, but the underlying mechanisms have not well been understood. Read More

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http://dx.doi.org/10.1007/s11064-019-02767-8DOI Listing

Foxp3 plasmid-encapsulated PLGA nanoparticles attenuate pain behavior in rats with spinal nerve ligation.

Nanomedicine 2019 Mar 8. Epub 2019 Mar 8.

Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 35015, Republic of Korea. Electronic address:

Microglia play a critical role in neuropathic pain. Since upregulated Foxp3 in microglia enhances tissue repair by resolving neuroinflammation in excitotoxin-induced neuronal death, it may attenuate neuropathic pain in a similar manner. Therefore, this study tests whether Foxp3 introduced with poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles (Foxp3 NPs) can alleviate neuropathic pain by inhibiting microglia activity. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.023DOI Listing

[EXPRESS] Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain.

Mol Pain 2019 Mar 11:1744806919840098. Epub 2019 Mar 11.

University of Texas Medical Branch.

Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse side effect of many anti-cancer chemotherapeutic treatments. CIPN often causes neuropathic pain in extremities, and oxidative stress has been shown to be a major contributing factor to this pain. In this study, we determined the site of oxidative stress associated with pain (specifically, mechanical hypersensitivity) in cisplatin- and paclitaxel-treated mouse models of CIPN and investigated the neurophysiological mechanisms accounting for the pain. Read More

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http://dx.doi.org/10.1177/1744806919840098DOI Listing
March 2019
1 Read

Sex Differences in a Rodent Model of HIV-1-Associated Neuropathic Pain.

Int J Mol Sci 2019 Mar 9;20(5). Epub 2019 Mar 9.

Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, School of Medicine Lubbock, Lubbock, TX 79430, USA.

Worldwide, women account for approximately 51% of human immunodeficiency virus-1 (HIV) seropositive individuals. The prevalence of neuropathic pain among individuals with HIV and a lack of preclinical data characterizing sex differences prompted us to address this knowledge gap. C57BL/6 male and female mice received multiple intrathecal injections of HIV-glycoprotein 120 (gp120), followed by determination of mechanical allodynia and thermal hypersensitivity for four weeks. Read More

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http://dx.doi.org/10.3390/ijms20051196DOI Listing

Can acupuncture help adults suffering from neuropathic pain? - A Cochrane Review summary with commentary.

Authors:
Livia Puljak

NeuroRehabilitation 2019 Mar 5. Epub 2019 Mar 5.

Center for Evidence-based Medicine and Health Care, Catholic University of Croatia, Zagreb, Croatia.

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http://dx.doi.org/10.3233/NRE-189004DOI Listing

Opioid-induced constipation in chronic pain: Experience with 180 patients.

J Opioid Manag 2019 Jan/Feb;15(1):69-76

Nurse, Pain Unit, Hospital de Alta Resolución de Guadix, Granada, Spain.

Background: Opioid-induced constipation (OIC) is a common adverse effect of opioid analgesic therapy that significantly affects the patient's quality of life and may lead to poor adherence and treatment failure. Tapentadol, oxycodone/naloxone, and some transcutaneous opioids were associated with less frequent OIC than morphine or oxycodone in controlled clinical trials. However, few studies compare these newer opioids with each other in terms of OIC. Read More

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http://dx.doi.org/10.5055/jom.2019.0487DOI Listing
March 2019
4 Reads

Diagnostic Criteria for Symptomatic Neuroma.

Ann Plast Surg 2019 Apr;82(4):420-427

Hand Surgery Service, Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Introduction: After nerve injury, disorganized or incomplete nerve regeneration may result in a neuroma. The true incidence of symptomatic neuroma is unknown, and the diagnosis has traditionally been made based on patient history, symptoms, physical examination, and the anatomic location of pain, along with response to diagnostic injection. There are no formally accepted criteria for a diagnosis of neuroma. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001796DOI Listing

Nerve Compression Syndromes in the Posterior Cranial Fossa.

Dtsch Arztebl Int 2019 Jan;116(4):54-60

Department of Neurosurgery, University Medicine Greifswald.

Background: Nerve compression syndromes in the posterior cranial fossa can severely impair patients' quality of life. There is often uncertainty about the best treatment. In this article, we provide an overview of these conditions and the corresponding treatment strategies. Read More

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http://dx.doi.org/10.3238/arztebl.2019.0054DOI Listing
January 2019

Intraoperative Management of an Enlarged Suprameatal Tubercle During Microvascular Decompression of the Trigeminal Nerve, Surgical and Anatomical Description: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2019 Mar 9. Epub 2019 Mar 9.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.

The suprameatal tubercle is a variable prominence of the posterior aspect of the petrous part of the temporal bone located above the internal acoustic meatus. An enlarged suprameatal tubercle (EST) may present an obstacle during posterior fossa operations, including microvascular decompression (MVD).  In this video we present the case of a 55-yr-old woman with 2 yr of medically refractory left V2-3 typical trigeminal neuralgia. Read More

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http://dx.doi.org/10.1093/ons/opz027DOI Listing

Retrosigmoid approach for glycerin rhizotomy in the treatment of trigeminal neuralgia without overt arterial compression: updated case series.

J Neurosurg 2019 Mar 8:1-7. Epub 2019 Mar 8.

1Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; and.

OBJECTIVETrigeminal neuralgia (TN) is a neuropathic pain disorder characterized by severe, lancinating facial pain that is commonly treated with neuropathic medication, percutaneous rhizotomy, and/or microvascular decompression (MVD). Patients who are not found to have distinct arterial compression during MVD present a management challenge. In 2013, the authors reported on a small case series of such patients in whom glycerin was injected intraoperatively into the cisternal segment of the trigeminal nerve. Read More

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http://dx.doi.org/10.3171/2018.12.JNS182572DOI Listing
March 2019
1 Read

A Systematic Review and Meta-analysis of Memantine for the Prevention or Treatment of Chronic Pain.

Eur J Pain 2019 Mar 8. Epub 2019 Mar 8.

Department of Anesthesiology, McMaster University, Michael DeGroote School of Medicine, Hamilton, Ontario, Canada.

Background And Objective: N-methyl-D-aspartate (NMDA) receptors are involved in pain signalling and neuroplasticity. Memantine has been shown to have analgesic properties in pre-clinical and small clinical studies. We conducted a systematic review and meta-analysis to assess the efficacy of memantine to prevent or reduce chronic pain. Read More

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http://dx.doi.org/10.1002/ejp.1393DOI Listing

MicroRNA-340-5p relieved chronic constriction injury-induced neuropathic pain by targeting Rap1A in rat model.

Genes Genomics 2019 Mar 8. Epub 2019 Mar 8.

Department of Neurology, Taizhou People's Hospital, No. 366 Taihu Road, Hailing District, Taizhou, 225300, Jiangsu, China.

Objectives: Neuropathic pain (NP) is one of the main challenges towards NP syndrome treatment. miR-340-5p exhibit different expression levels in NP models. Its effects on NP remained unclear. Read More

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http://dx.doi.org/10.1007/s13258-019-00802-0DOI Listing
March 2019
1 Read

Efficacy of Human Cell-seeded Muscle-Stuffed Vein Conduit in Rat Sciatic Nerve Repair.

Tissue Eng Part A 2019 Mar 8. Epub 2019 Mar 8.

Universiti Kebangsaan Malaysia Medical Centre, Tissue Engineering Centre, Kuala Lumpur, Malaysia ;

We investigated the efficacy of a muscle-stuffed vein seeded with neural-transdifferentiated human mesenchymal stem cells as an alternative nerve conduit to repair a 15-mm sciatic nerve defect in athymic rats.Other rats received either muscle-stuffed vein conduit alone, commercial polyglycolic acid conduit (Neurotube®), reverse autograft or were left untreated. Motor and sensory functions as well as nerve conductivity were evaluated for 12 weeks, after which the grafts were harvested for histological analyses. Read More

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http://dx.doi.org/10.1089/ten.TEA.2018.0279DOI Listing

Assessment of experimental orofacial pain, pleasantness and unpleasantness via standardised psychophysical testing.

Eur J Pain 2019 Mar 7. Epub 2019 Mar 7.

Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Denmark.

Background: Somatosensory assessment within the orofacial region may be performed using highly standardised quantitative sensory testing (QST). However, the function of the C tactile (CT) afferent, a nerve fibre linked to the perception of pleasant touch, is usually not evaluated. Furthermore, the perception of unpleasantness is also rarely assessed; a dimension not only limited to a painful experience. Read More

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http://dx.doi.org/10.1002/ejp.1391DOI Listing

[Headache - an Update 2018].

Laryngorhinootologie 2019 Mar 7;98(3):192-217. Epub 2019 Mar 7.

Epidemiological studies have shown a clear correlation between migraine and vascular disease in more and more patients. Pathophysiological studies show the relevance of the hypothalamus in the generation of migraine attacks. Glutamate seems to play an important role here. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0823-4814
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http://dx.doi.org/10.1055/a-0823-4814DOI Listing
March 2019
3 Reads

Assessing stress associated with temporomandibular joint disorder through Fonseca's anamnestic index among the Saudi physicians.

Clin Exp Dent Res 2019 Feb 26;5(1):52-58. Epub 2018 Dec 26.

College of Medicine King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia.

The study aims to investigate signs and symptoms of temporomandibular disorders (TMD) among physicians in a tertiary health-care center. It has estimated the level of symptomatology, determined the association with demographic data, and identified the related occupational risk factors. A cross-sectional survey was used, and physicians of genders, all age groups, and nationalities from King Abdulaziz Medical City in Riyadh, Saudi Arabia, were recruited. Read More

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http://dx.doi.org/10.1002/cre2.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392863PMC
February 2019
1 Read

Renal Cell Carcinoma with Primary Presentation via Metastasis to the Trigeminal Ganglion.

World Neurosurg 2019 Mar 4. Epub 2019 Mar 4.

Departments of Neurologic Surgery, Mayo Clinic, Rochester MN; Departments of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester MN. Electronic address:

Introduction: Renal cell carcinoma (RCC) accounts for approximately 8% of all brain metastatic disease; however, spread to the cranial nerves and their ganglia is uncommon. We report the first case of RCC metastatic to Meckel's cave, which was diagnosed secondary to new trigeminal sensory loss.

Methods: Case report RESULTS: A 45-year-old man presented with acute-onset right V3 numbness. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.118DOI Listing
March 2019
2 Reads

Perioperative pregabalin and intraoperative lidocaine infusion to reduce persistent neuropathic pain after breast cancer surgery: a multicenter, factorial, randomized controlled pilot trial.

J Pain 2019 Mar 4. Epub 2019 Mar 4.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Persistent post-surgical pain is defined as pain localized to the area of surgery of at least 2-month duration and is unfortunately a common complication after breast cancer surgery. While there is insufficient evidence to support any preventative strategy, prior literature suggests possible efficacy of intravenous lidocaine and perioperative pregabalin in preventing persistent pain after surgery. To determine feasibility of conducting a larger definitive trial, we conducted a multicenter 2-by-2 factorial randomized placebo-controlled pilot trial of 100 female patients undergoing breast cancer surgery. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.02.010DOI Listing

Which drug treatments are best for trigeminal neuralgia?

Authors:

Drug Ther Bull 2019 Mar 6. Epub 2019 Mar 6.

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http://dx.doi.org/10.1136/dtb.2019.000015DOI Listing

Interventional and preventive effects of aripiprazole and ceftriaxone used alone or in combination on oxaliplatin-induced tactile and cold allodynia in mice.

Biomed Pharmacother 2019 Mar 8;111:882-890. Epub 2019 Jan 8.

Faculty of Production Engineering, Warsaw University of Life Sciences, 164 Nowoursynowska St., 02-787 Warsaw, Poland.

Background And Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a pharmacoresistant neurological complication induced by some antitumor drugs. This study aimed to assess antiallodynic properties of aripiprazole and ceftriaxone used alone or in combination to attenuate neuropathic pain related to CIPN caused by oxaliplatin.

Methods: Neuropathic pain was induced in mice by a single intraperitoneal dose of oxaliplatin (10 mg/kg). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.008DOI Listing

Plasticity in the dynamic pain connectome associated with ketamine-induced neuropathic pain relief.

Pain 2019 Mar 4. Epub 2019 Mar 4.

Division of Brain, Imaging & Behaviour Systems, Krembil Brain Institute, Krembil Research Institute, Toronto M5T 2S8, Canada.

Therapeutic interventions for neuropathic pain (NP), such as the NMDA-antagonist ketamine, can vary widely in effectiveness; Here, we conducted a longitudinal functional MRI study to test the hypothesis that the pain relieving effect of ketamine is due to reversal of abnormalities in regional low frequency brain oscillations (LFOs) and abnormal cross-network functional connectivity (FC) of the dynamic pain connectome. We found that: 1) ketamine decreased regional LFOs in the posterior cingulate cortex (PCC) of the default mode network (DMN), 2) a machine learning algorithm demonstrated that treatment-induced brain changes could be used to make generalizable inferences about pain relief, 3) treatment responders exhibited a significant decrease in cross-network static FC between the PCC and regions of the sensorimotor (SM) and salience networks following treatment, 4) the degree of reduced cross-network FC was correlated with the amount of pain relief, and 5) ketamine treatment did not produce significant differences in static or dynamic FC within the ascending nociceptive- or descending antinociceptive pathway. These findings support the proposition that regional LFOs contribute to cross-network connectivity that underlie the effectiveness of ketamine to produce significant relief of neuropathic pain. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001545DOI Listing

α2δ-1-Bound N-Methyl-D-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents.

Anesthesiology 2019 Feb 27. Epub 2019 Feb 27.

From the Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas (M.D., S.-R.C., H.C., H.-L.P.) the Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha, Hunan, China (M.D.).

What We Already Know About This Topic: Presynaptic N-methyl-D-aspartate receptors contribute to opioid tolerance and hyperalgesia as well as neuropathic painThe α2δ-1 protein subunit enhances presynaptic N-methyl-D-aspartate receptor activity WHAT THIS ARTICLE TELLS US THAT IS NEW: Using mouse and rat models, it was demonstrated that α2δ-1 is essential for the increase in presynaptic N-methyl-D-aspartate receptor activity seen during chronic morphine exposureInhibiting α2δ-1 activity using gabapentin or genetically deleting the gene coding for α2δ-1 results in diminished opioid tolerance and hyperalgesia BACKGROUND:: Chronic use of μ-opioid receptor agonists paradoxically causes both hyperalgesia and the loss of analgesic efficacy. Opioid treatment increases presynaptic N-methyl-D-aspartate receptor activity to potentiate nociceptive input to spinal dorsal horn neurons. However, the mechanism responsible for this opioid-induced activation of presynaptic N-methyl-D-aspartate receptors remains unclear. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002648DOI Listing
February 2019

Oral Lactobacillus reuteri LR06 or Bifidobacterium BL5b supplement do not produce analgesic effects on neuropathic and inflammatory pain in rats.

Brain Behav 2019 Mar 6:e01260. Epub 2019 Mar 6.

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.

Background: Previous studies have reported that certain bacteria exert visceral antinociceptive activity in visceral pain and may also help to relieve neuropathic and inflammatory pain.

Objective: The aim of this study was to explore the analgesic effect of Lactobacillus reuteri LR06 (LR06) or Bifidobacterium BL5b (BL5b) in chronic pain in vivo.

Design: Rats were randomly assigned into four groups: sham, Chronic Constriction Injury (CCI)/Complete Freund's Adjuvant (CFA) + control, CCI/CFA + LR06, and CCI/CFA + BL5b. Read More

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http://dx.doi.org/10.1002/brb3.1260DOI Listing