7,267 results match your criteria Journal of Neuroimmunology[Journal]


Pontine hemorrhage accompanied by neuromyelitis optica spectrum disorder.

J Neuroimmunol 2019 Feb 1;330:19-22. Epub 2019 Feb 1.

Department of Neurology, Juntendo University Faculty of Medicine, Japan.

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder caused by antibody to aquaporin-4 (AQP4). NMOSD can infrequently present as a complication of posterior reversible encephalopathy syndrome (PRES). Moreover, few cases of NMOSD patients with brain hemorrhage have been reported. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.020DOI Listing
February 2019

The expansion of circulating IL-6 and IL-17-secreting follicular helper T cells is associated with neurological disabilities in neuromyelitis optica spectrum disorders.

J Neuroimmunol 2019 Jan 25;330:12-18. Epub 2019 Jan 25.

Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Microbiology, Immunology and Parasitology, Rio de Janeiro State University, Rio de Janeiro, Brazil; Departament of Neurology, Federal University of the State of Rio de Janeiro, Brazil. Electronic address:

Due to their function in assisting B cells, T cells may be involved in the production of pathogenic IgG in neuromyelitis optica spectrum disorder (NMOSD). In the present study, the proportion of IL-6 and IL-17 T cell subsets was higher in NMOSD patients than healthy individuals. The frequency of both T cell subsets were directly associated with disease activity. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.015DOI Listing
January 2019

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes.

J Neuroimmunol 2019 Feb 7;330:5-11. Epub 2019 Feb 7.

Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, USA.

Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.002DOI Listing
February 2019

Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis.

J Neuroimmunol 2019 Jan 23. Epub 2019 Jan 23.

Juntendo University, Department of Neurology, Tokyo, Japan; Juntendo University, Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable disease, Tokyo, Japan.

Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease in ruminants, has been linked as a possible risk factor for human multiple sclerosis. In the current study we investigated the adjuvant effect of MAP on experimental autoimmune encephalomyelitis (EAE). Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.013DOI Listing
January 2019
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Atypical presentation of fulminant primary central nervous system angiitis.

J Neuroimmunol 2019 Feb 1;330:1-4. Epub 2019 Feb 1.

Department of Critical Care Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada. Electronic address:

Background: Primary Angiitis of the Central Nervous System (PACNS) is a rare cause of CNS vasculitis that should be included as part complete differential diagnosis, especially in cases with suggestive imaging findings and an absence of secondary causes for CNS vasculitis.

Case Presentation: We describe a case of a 47-year-old previously healthy Caucasian male presenting with rapid progression of encephalopathy and fevers. Extensive infectious, autoimmune, and imaging workups were unrevealing. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.019DOI Listing
February 2019

Tongue tremor in neurofascin-155 IgG4 seropositive chronic inflammatory polyradiculoneuropathy.

J Neuroimmunol 2019 Jan 29. Epub 2019 Jan 29.

Laboratory of Neuroimmunology, IRCCS Mondino Foundation, Pavia, Italy.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with anti-neurofascin-155 antibodies is a subgroup of CIDP with tremor and poor response to intravenous immunoglobulins. A 23-year-old male presented with a 6-month history ataxic-stepping gait, stocking tactile hypoesthesia, areflexia, tremor at limbs and tongue. Neurophysiology and cerebrospinal fluid analysis supported the diagnosis of CIDP. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.017DOI Listing
January 2019
1 Read

Corrigendum to "Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway" [J. Neuroimmunol. 299 (2016) 164-171].

J Neuroimmunol 2019 Feb;327:44

Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.016DOI Listing
February 2019

Muscarinic acetylcholine receptor expression in brain and immune cells of Oreochromis niloticus.

J Neuroimmunol 2019 Mar 22;328:105-107. Epub 2019 Jan 22.

Universidad Autónoma de Nayarit, Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Boulevard Tepic-Xalisco s/n. Cd, de la Cultura Amado Nervo, C.P. 63000 Tepic, Nayarit, Mexico; Centro Nayarita de Innovación y Transferencia de Tecnología A.C., Laboratorio Nacional para la Investigación en Inocuidad Alimentaria-Unidad Nayarit, Calle Tres s/n. Cd Industrial, Tepic, Nayarit, Mexico. Electronic address:

Nervous and immune systems maintain a bidirectional communication, expressing receptors for neurotransmitters and cytokines. Despite being well established in mammals, this has been poorly described in lower vertebrates as fishes. Experimental evidence shows that the neurotransmitter acetylcholine (ACh) regulates the immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728193001
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http://dx.doi.org/10.1016/j.jneuroim.2019.01.012DOI Listing
March 2019
4 Reads

Altered naive CD4 T cell homeostasis in myasthenia gravis and thymoma patients.

J Neuroimmunol 2019 Feb 11;327:10-14. Epub 2019 Jan 11.

Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Germany.

In Myasthenia Gravis (MG) thymic pathologies are often present and thymectomy is used as treatment. By flow cytometry we elucidated alterations of naïve CD4 T cell homeostasis in MG patients and patients with thymoma. MG patients showed increased absolute numbers of CD31naïve CD4 T cells. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.005DOI Listing
February 2019
1 Read

NMDA receptor antibody encephalitis presenting as Transient Epileptic Amnesia.

J Neuroimmunol 2019 Feb 22;327:41-43. Epub 2019 Jan 22.

Cognitive Neurology Research Group, University of Exeter Medical School, Exeter, UK.

Transient Epileptic Amnesia (TEA) is a subtype of temporal lobe epilepsy, typically presenting in a person's early 60s, and of unknown aetiology. Encephalitis caused by antibodies to NMDA receptors (NMDARE) has not previously been documented in TEA. We describe a 47-year-old male who satisfied criteria for TEA, but given his atypical symptoms, was also screened for autoimmune epilepsy. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367595PMC
February 2019

Pancreatic ductal cell antigens are important in the development of invasive insulitis in Non-Obese Diabetic mice.

J Neuroimmunol 2019 Feb 18;327:1-9. Epub 2019 Jan 18.

Department of Immunology and Pathology, Monash University, Melbourne, Australia.

Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to GFAP expressing cell types precede the islet autoimmunity in Non-Obese Diabetic (NOD) mice. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.001DOI Listing
February 2019

Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure.

J Neuroimmunol 2019 Feb 17;327:36-40. Epub 2019 Jan 17.

Neuroimmunology Laboratory, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Segol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Demyelination, axonal loss and failure of tissue repair characterize MS lesions. Bone morphogenetic proteins (BMPs) signaling is associated with remyelination failure. Coco is one of the BMP antagonists. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.009DOI Listing
February 2019
1 Read

Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis.

J Neuroimmunol 2019 Feb 17;327:15-21. Epub 2019 Jan 17.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Multiple sclerosis is a chronic incapacitating disease of the central nervous system, it has been reported that the disturbance in the development and function of Treg subpopulations is associated with the disability status in the RRMS. Accordingly, in the current study, the objective was to specify nanocurcumin effects on Treg cells frequency, and function in patients with RRMS.

Methods And Materials: 50 patients with RRMS were enrolled in this study in which 25 were treated for at least six months with nanocurcumin capsules while the other half received placebo capsules as the control group. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.007DOI Listing
February 2019
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2.467 Impact Factor

Modulation of the extraneuronal cholinergic system on main innate response leukocytes.

J Neuroimmunol 2019 Feb 17;327:22-35. Epub 2019 Jan 17.

Universidad Autónoma de Nayarit, Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Boulevard Tepic-Xalisco s/n, Cd de la Cultura Amado Nervo, C.P. 63000 Tepic, Nayarit, Mexico; Centro Nayarita de Innovación y Transferencia de Tecnología A.C. Laboratorio Nacional para la Investigación en Inocuidad Alimentaria-Unidad Nayarit, Calle Tres s/n. Cd Industrial, Tepic, Nayarit, Mexico. Electronic address:

The expression of elements of the cholinergic system has been demonstrated in non-neuronal cells, such as immune cells, where acetylcholine modulates innate and adaptive responses. However, the study of the non-neuronal cholinergic system has focused on lymphocyte cholinergic mechanisms, with less attention to its role of innate cells. Considering this background, the aims of this review are 1) to review information regarding the cholinergic components of innate immune system cells; 2) to discuss the effect of cholinergic stimuli on cell functions; 3) and to describe the importance of cholinergic stimuli on host immunocompetence, in order to set the base for the design of intervention strategies in the biomedical field. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.008DOI Listing
February 2019

Gut microbiota in neurodegenerative disorders.

J Neuroimmunol 2019 Mar 9;328:98-104. Epub 2019 Jan 9.

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India. Electronic address:

Gut dysbiosis, a primary factor behind various gastrointestinal disorders may also augment lipopolysaccharides, pro-inflammatory cytokines, T helper cells and monocytes causing increased intestinal and BBB permeability via microbiota-gut-brain axis. Consequentially, accumulation of misfolded proteins, axonal damage and neuronal demyelination sets in, thus facilitating the pathogenesis of neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, multiple sclerosis and amyotrophic lateral sclerosis. Studies revealed that intake of probiotics may help in the integrity of intestinal and BBB thus ameliorating the above neurodegenerative disorders. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183045
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http://dx.doi.org/10.1016/j.jneuroim.2019.01.004DOI Listing
March 2019
12 Reads

Clinical characterization of anti-GQ1b antibody syndrome in Korean children.

J Neuroimmunol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine, Biomedical Research Institute, Busan, South Korea. Electronic address:

Anti-GQ1b antibody syndrome encompasses Miller Fisher syndrome and its related disorders. We retrospectively identified 11 pediatric patients (5.4-18 years old) with anti-GQ1b antibody syndrome. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.003DOI Listing
January 2019
1 Read

Immune cell derived BDNF does not mediate neuroprotection of the murine anti-CD52 antibody in a chronic autoimmune mouse model.

J Neuroimmunol 2019 Mar 27;328:78-85. Epub 2018 Dec 27.

Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany.

The murine anti-CD52 antibody, an equivalent of the humanized antibody alemtuzumab, which is successfully used in the treatment of multiple sclerosis, was used to explore a potential neuroprotective effect driven by immune cell derived brain-derived neurotrophic factor (BDNF). Therefore, lineage specific constitutive knock-out mice with a BDNF deficiency in T cells and macrophages were used and compared to treated wildtype mice. Neither therapeutic nor preventive application of the murine anti-CD52 antibody in an animal model of multiple sclerosis, the MOG EAE, revealed a beneficial contribution of immune cell derived BDNF to the disease outcome. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.12.010DOI Listing

The frequency of varicella-zoster virus infection in patients with multiple sclerosis receiving fingolimod.

J Neuroimmunol 2019 Mar 26;328:94-97. Epub 2018 Dec 26.

Department of Virology, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Multiple Sclerosis (MS) is thought to be an autoimmune disease of the central nervous system (CNS), in which the immune system becomes activated, cross the blood-brain barrier (BBB), and cause neuroinflammation and neurodegeneration. Fingolimod is considered a disease-modifying therapy (DMT), possessing immunomodulatory effects on the immune system, especially autoreactive T cells being licensed in lymph nodes. Although the fidelity of the drug is undeniable in the management of disease course, various adverse effects have been reported in some patients taking this medication. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.12.009DOI Listing
March 2019
2 Reads
2.467 Impact Factor

Calcitriol, but not FGF23, increases in CSF and serum of MS patients.

J Neuroimmunol 2019 Mar 30;328:89-93. Epub 2018 Dec 30.

Iranian Center of Neurological Research, Neuroscience Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

The anti-inflammatory role of the active metabolite of vitamin D, namely 1, 25-dihydroxyvitamin D (calcitriol), has been reported in multiple sclerosis (MS). Moreover, recent studies have shown that fibroblast growth factor 23 (FGF23) is involved in the regulation of calcitriol biosynthesis. The probable changes of FGF23 and calcitriol concentrations in the CSF and serum of patients with MS were evaluated. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.12.011DOI Listing

A case of recurrent MOG antibody positive bilateral optic neuritis and anti-NMDAR encephalitis: Different biological evolution of the two associated antibodies.

J Neuroimmunol 2019 Mar 14;328:86-88. Epub 2018 Dec 14.

Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

We report the clinical association of myelin-oligodendrocyte-glycoprotein (MOG) IgG-associated encephalomyelitis (MOG-EM) and anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. A 47-year old male presented to our hospital with right eye optic neuritis in February 2018. He had a history of recurrent bilateral optic neuritis since 2001 and in 2013 was treated of a anti-NMDAR encephalitis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183050
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http://dx.doi.org/10.1016/j.jneuroim.2018.12.003DOI Listing
March 2019
1 Read

Association of typhoid fever with anti-NMDAR encephalitis in a young child.

J Neuroimmunol 2019 Mar 27;328:76-77. Epub 2018 Dec 27.

Opthalmology and Corneal Surgery, SK Soni Hospital, Jaipur, India.

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http://dx.doi.org/10.1016/j.jneuroim.2018.12.006DOI Listing
March 2019
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Rheumatoid meningitis sine arthritis.

J Neuroimmunol 2019 Mar 19;328:73-75. Epub 2018 Dec 19.

Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Address: 211 South 9(th) Street, Walnut Towers Suite 210, Philadelphia, PA 19107, United States. Electronic address:

Rheumatoid meningitis is a rare and very serious extra-articular manifestation of rheumatoid arthritis. We present a case of a 7()year-old female with no history of arthritis who developed stroke-like symptoms, seizures, psychosis and compulsive behavior. Serial brain magnetic resonance images (MRI) over four months demonstrated progressive interhemispheric meningeal thickening. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183048
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http://dx.doi.org/10.1016/j.jneuroim.2018.12.001DOI Listing
March 2019
4 Reads

Increased protein expression of VEGF-A, VEGF-B, VEGF-C and their receptors in the temporal neocortex of pharmacoresistant temporal lobe epilepsy patients.

J Neuroimmunol 2019 Mar 21;328:68-72. Epub 2018 Dec 21.

Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Zapopan, Jalisco, Mexico. Electronic address:

The vascular endothelial growth factor (VEGF) system has been shown to play a crucial role in several neuropathological processes. Temporal lobe epilepsy (TLE) is the most common focal epilepsy type in adult humans. We assessed the protein expression levels of VEGF-A, VEGF-B, and VEGF-C, their specific receptors VEGFR-2 and -3, their accessory receptors neuropilins 1 and 2, and PI3 and Akt kinases, in temporal neocortex from pharmacoresistant TLE (PR-TLE) patients and control subjects by western blotting. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.12.007DOI Listing

Effects of moderate- versus high- intensity swimming training on inflammatory and CD4 T cell subset profiles in experimental autoimmune encephalomyelitis mice.

J Neuroimmunol 2019 Mar 18;328:60-67. Epub 2018 Dec 18.

Institute of Infection and Immunity of Huaihe Hospital, Henan University, Kaifeng 475000, China. Electronic address:

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system (CNS). Evidence about experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, has been shown to modulate disease parameters within exercise intervention. However, these initial studies weren't carried out intensity of exercise in mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183047
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http://dx.doi.org/10.1016/j.jneuroim.2018.12.005DOI Listing
March 2019
6 Reads

Malat1 long noncoding RNA regulates inflammation and leukocyte differentiation in experimental autoimmune encephalomyelitis.

J Neuroimmunol 2019 Mar 28;328:50-59. Epub 2018 Nov 28.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

In this study, we investigated the contributions of the MALAT1 long noncoding RNA to autoimmune neuroinflammation in central nervous system tissues from patients with multiple sclerosis (MS) and mice with experimental autoimmune encephalomyelitis (EAE). Expression of MALAT1 was decreased in the spinal cords of EAE mice as well as in stimulated splenocytes and primary macrophages. MALAT1 downregulation by specific siRNAs enhanced the polarization of macrophages towards the M1 phenotype. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.013DOI Listing
March 2019
1 Read

Cumulative influence of parity-related genomic changes in multiple sclerosis.

J Neuroimmunol 2019 Mar 17;328:38-49. Epub 2018 Dec 17.

Centre for Clinical Research, UQ CCR, The University of Queensland, Queensland, Australia. Electronic address:

Pregnancy reduces the frequency of relapses in Multiple Sclerosis (MS) and parity also has a beneficial long term effect on disease outcome. We aimed to uncover the biological mechanisms underlying the beneficial long-term effects of parity in MS. Genome-wide gene expression revealed 574 genes associated with parity; 38. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183035
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http://dx.doi.org/10.1016/j.jneuroim.2018.12.004DOI Listing
March 2019
7 Reads

NMDAR encephalitis presenting as akinesia in a patient with Parkinson disease.

J Neuroimmunol 2019 Mar 12;328:35-37. Epub 2018 Dec 12.

Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy. Electronic address:

We describe the case of a woman with Parkinson disease who developed an N-methyl-d-aspartate receptor antibody-mediated encephalitis. As a novelty, the encephalitis presentation mimicked a worsening of the pre-existing extrapyramidal syndrome, manifesting mainly as severe bradykinesia and, eventually, akinesia. Brain MRI was normal, whereas cerebrospinal fluid (CSF) analysis disclosed unique-to-CSF oligoclonal bands. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.12.002DOI Listing
March 2019
2 Reads

Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: Focus on mesenchymal stem cells and neuroprotection.

J Neuroimmunol 2019 Mar 1;328:20-34. Epub 2018 Dec 1.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) which predominantly affect young adults and undergo heavy socioeconomic burdens. Conventional therapeutic modalities for MS mostly downregulate aggressive immune responses and are almost insufficient for management of progressive course of the disease. Mesenchymal stem cells (MSCs), due to both immunomodulatory and neuroprotective properties have been known as practical cells for treatment of neurodegenerative diseases like MS. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.015DOI Listing

Syngeneic, in contrast to allogeneic, mesenchymal stem cells have superior therapeutic potential following spinal cord injury.

J Neuroimmunol 2019 Mar 16;328:5-19. Epub 2018 Nov 16.

Department of Neurology and Neurosurgery, Karolinska University Hospital, BioClinicum, Solnavägen 30, Solna, Stockholm 17176, Sweden; Center for Molecular Medicine, Karolinska Institutet, Solna 17176, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Solna 17176, Stockholm, Sweden. Electronic address:

We evaluated the importance of histocompatibility of transplanted MSCs in terms of therapeutic potential. Mouse syngeneic MSCs or allogeneic MSCs were transplanted following SCI in mouse. In this study we found that syngeneic, but not allogeneic, MSCs alternatively activated macrophages resulting in a down-regulation of pro-inflammation. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.005DOI Listing
March 2019
10 Reads

Gelatin hydrogel containing cerium oxide nanoparticles covered by interleukin-17 aptamar as an anti- inflammatory agent for brain inflammation.

J Neuroimmunol 2019 Jan 23;326:79-83. Epub 2018 Nov 23.

Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Medical biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran. Electronic address:

The purpose of this study was to evaluate the anti-inflammatory property of gelatin hydrogel containing cerium oxide nanoparticles coated with interleukin-17 Aptemer ([CeON@IL-17]). Here, the brain inflammation model was induced by both proteolipid protein (PLP) and parathion. Then, the expression of some inflammatory genes and the serum level of related interleukins were evaluated. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.011DOI Listing
January 2019
2 Reads

The clinical and prognostic value of antinuclear antibodies in NMO-IgG seropositive neuromyelitis optica spectrum disorder.

J Neuroimmunol 2019 Mar 28;328:1-4. Epub 2018 Nov 28.

Department of Neurology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, South Korea. Electronic address:

In neuromyelitis optica spectrum disorders (NMOSD), the clinical and long-term prognostic value of antinuclear antibodies (ANAs) is unclear. We analyzed registry data of NMO-IgG seropositive NMOSD patients (n = 74) according to ANA presence. The ANA-positive group (n = 32) demonstrated more frequent other autoantibodies (anti-SSA/Ro, anti-SSB/La, antiphospholipid, and anti-double stranded DNA antibodies) than did the ANA-negative group (n = 42). Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.012DOI Listing
March 2019
2 Reads

Liposomal prodigiosin and plasmid encoding serial GCA nucleotides reduce inflammation in microglial and astrocyte cells by ATM/ATR signaling.

J Neuroimmunol 2019 Jan 1;326:75-78. Epub 2018 Dec 1.

Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran. Electronic address:

The aim of this study was to use liposomal structure consisting prodigiosin and plasmid encoding serial GCA nucleotides (LP/pSGCAN) to reduce inflammation in microglial cells (MGCs) and astrocyte cells (ACCs) by ATM/ATR signaling. Here, it was shown that LP/pSGCAN decreased cell viability and total RNA level. Importantly, LP/pSGCAN had more effect on ACCs than MGCs (P < 0. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.014DOI Listing
January 2019

Corrigendum to "Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway" [J. Neuroimmunol. 299 (2016) 164-171].

J Neuroimmunol 2019 Jan 5;326:84-85. Epub 2018 Dec 5.

Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2018.08.006DOI Listing
January 2019

Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease.

J Neuroimmunol 2019 Jan 20;326:62-74. Epub 2018 Nov 20.

Department of Pharmacology, SPP School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India. Electronic address:

Microglial activation is a distinguished attribute in many neurodegenerative diseases of aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the resident macrophage-like immune cells in the brain, play a contributing role in the pathogenesis of Alzheimer's disease (AD). Postmortem brain tissue of individuals with AD has credibly demonstrated that neuroinflammation is likely to be a key driver of the disease. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.010DOI Listing
January 2019
1 Read

Sulfatides ameliorate experimental autoimmune neuritis by suppressing Th1/Th17 cells.

J Neuroimmunol 2019 Jan 14;326:55-61. Epub 2018 Nov 14.

Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China. Electronic address:

Sulfatides have immunomodulatory functions, and play protective roles in multiple autoimmune diseases. In the present study, we showed that sulfatides ameliorated experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin, which was associated with decreased proportions of Th1 and Th17 cells. Furthermore, compared control group, cells from sulfatide-treated rats exhibited lower potential in proliferation and IL-17 secretion in the presence of BPM or ConA in vitro. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.008DOI Listing
January 2019
11 Reads

Interferon-beta treated-multiple sclerosis patients exhibit a decreased ratio between immature/transitional B cell subset and plasmablasts.

J Neuroimmunol 2019 Jan 16;326:49-54. Epub 2018 Nov 16.

Unidade de Gestão Operacional de Citometria, Serviço de Patologia Clínica, Centro Hospitalar e Universitário de Coimbra, Praceta Mota Pinto, 3001-301 Coimbra, Portugal; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculdade de Medicina, Universidade de Coimbra, Polo III - Health Sciences Campus Azinhaga Santa Comba, Celas, 3000-548 Coimbra, Portugal; Escola Superior de Tecnologia da Saúde de Coimbra, Rua 5 de Outubro, 3046-854 Coimbra, Portugal. Electronic address:

Our aim was to quantify circulating B cell subsets; immature/transitional, naïve, CD27 and CD27 memory cells and plasmablasts, in relapsing-remitting multiple sclerosis patients treated with IFN-β. The most relevant findings were a significant increase of plasmablasts and a decrease of immature/transitional B cells, resulting in a decreased ratio between those cells in relapse RRMS, together with an increase of CD27 and CD27IgM memory B cell subsets in both phases of the disease. These alterations point to an active B cell response, particularly in relapse, and the above referred ratio could constitute a good biomarker of relapse in patients that underwent IFN-β treatment. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.001DOI Listing
January 2019
2 Reads

Exploring the relationship between Endothelin-1 and peripheral inflammation in multiple sclerosis.

J Neuroimmunol 2019 Jan 15;326:45-48. Epub 2018 Nov 15.

Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.

Background: Identifying pathways linking neuroinflammation and neurodegeneration is essential to help prevent disability progression in people with multiple sclerosis (MS). Endothelin-1 (ET-1) is a potent vasoconstrictor thought to contribute to cerebral hypoperfusion and tissue damage in MS. Its link with the neuroinflammatory process remains poorly investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183040
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http://dx.doi.org/10.1016/j.jneuroim.2018.11.007DOI Listing
January 2019
8 Reads

The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation.

J Neuroimmunol 2019 Jan 26;326:38-44. Epub 2018 Oct 26.

Department of Neurology at the University Medical Center Hamburg- Eppendorf, Hamburg, Germany.

Cerebral endothelial cells accomplish numerous tasks connected to the maintenance of homeostasis of the central nervous system. They create a barrier between the central nervous system and peripheral blood and regulate mechanotransduction, vascular permeability, rheology, thrombogenesis, and leukocyte adhesion. In pathophysiological conditions (e. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.10.012DOI Listing
January 2019
7 Reads

T cells in the post-ischemic brain: Troopers or paramedics?

J Neuroimmunol 2019 Jan 13;326:33-37. Epub 2018 Nov 13.

Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany. Electronic address:

The immune system is intricately involved in brain development and physiological neuronal function. The influence of the adaptive immune system on several brain diseases has been described in great detail. In ischemic stroke, numerous studies have particularly demonstrated a key role for T cells during the acute phase after the brain injury. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.006DOI Listing
January 2019
7 Reads

Rituximab treatment in seronegative autoimmune autonomic neuropathy and autoimmune autonomic ganglionopathy: Case-report and literature review.

J Neuroimmunol 2019 Jan 14;326:28-32. Epub 2018 Nov 14.

Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Reims, France; University of Reims Champagne-Ardenne, EA-4684 / SFR CAP-SANTE, Reims F-51095, France. Electronic address:

Background And Purpose: Autoimmune autonomic ganglionopathy (AAG) is a rare disease with no well-established treatment. Until recently, AAG could be seropositive (50 to 60% of patients) or seronegative for ganglionic (α3-type) nicotinic acetylcholine receptor (Gα3NAChR) antibodies. In early 2018, the two forms of the disease were distinguished, separating seropositive from seronegative ones, designating this latter form "seronegative autoimmune autonomic neuropathy" (SAAN). Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.009DOI Listing
January 2019
15 Reads

Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study.

J Neuroimmunol 2019 Jan 7;326:19-27. Epub 2018 Nov 7.

Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-β) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-β-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-β ADA in patients' sera. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.002DOI Listing
January 2019
30 Reads

How is the formation of microthrombi after traumatic brain injury linked to inflammation?

J Neuroimmunol 2019 Jan 31;326:9-13. Epub 2018 Oct 31.

Department of Neurosurgery, University Hospital of Würzburg, Würzburg, Germany. Electronic address:

Traumatic brain injury (TBI) is characterized by mechanical disruption of brain tissue due to an external force and by subsequent secondary injury. Secondary brain injury events include inflammatory responses and the activation of coagulation resulting in microthrombi formation in the brain vasculature. Recent research suggests that these mechanisms do not work independently. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.10.011DOI Listing
January 2019
7 Reads

The utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders.

J Neuroimmunol 2019 Jan 8;326:14-18. Epub 2018 Nov 8.

Department of Pathology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham NG7 2UH, UK.

Antibodies to SOXB1 proteins in patients with paraneoplastic disorders are associated with small-cell lung cancer (SCLC), particularly in Lambert-Eaton myasthenic syndrome (LEMS). We aimed to establish if SOX2 antibodies could be used to identify SCLC and other tumours found in a range of paraneoplastic disorders and controls. SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.003DOI Listing
January 2019
3 Reads

Antagonism of adenosinergic system decrease SWD occurrence via an increment in thalamic NFkB and IL-6 in absence epilepsy.

J Neuroimmunol 2019 Jan 7;326:1-8. Epub 2018 Nov 7.

Department of Physiology, Medical Faculty of Kocaeli University, Kocaeli, Turkey. Electronic address:

Epilepsy is a major pathological condition, characterized by recurrent seizures and affecting approximately 1% of the population. Many studies have shown a relationship between epilepsy and inflammation. The adenosinergic system contributes to inflammation and epilepsy by regulating the release of neurotransmitters through its various receptors. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.11.004DOI Listing
January 2019
2 Reads

Increased expression of the membrane-bound CD40 ligand on peripheral CD4 T cells in the acute phase of AQP4-IgG-seropositive neuromyelitis optica spectrum disorders.

J Neuroimmunol 2018 Dec 1;325:64-68. Epub 2018 Nov 1.

Department of Neurology, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Currently, no data are available regarding the expression levels of CD40L on CD4 T cells in patients with neuromyelitis optica spectrum disorders (NMOSD). The percentage of circulating CD40LCD4 T cells was measured by flow cytometry in 23 NMOSD patients and 10 healthy controls. The ratio of CD40LCD4 to CD4 T cells in patients at acute phase (18. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.10.013DOI Listing
December 2018

Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?

J Neuroimmunol 2018 Dec 19;325:61-63. Epub 2018 Oct 19.

Neurology Unit, Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Recent studies suggest a role of the autoimmune system dysregulation in Frontotemporal dementia (FTD). In the present study, we performed a broad immunological screening in a large sample of sporadic FTD patients. We reported a significant increase of antinuclear autoantibodies (ANA) positivity in 100 FTD patients as compared to 100 healthy controls (HC) (60% vs. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.10.006DOI Listing
December 2018

Novel autoantibodies against the proteasome subunit PSMA7 in amyotrophic lateral sclerosis.

J Neuroimmunol 2018 Dec 1;325:54-60. Epub 2018 Oct 1.

Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

Objective: To identify autoantibodies using sera from ALS patients and elucidate their roles in disease pathology.

Methods: An immunological screening was performed with a phage expression library SEREX method using sera from 3 ALS patients to identify ALS-related autoantibodies. Levels of antibodies identified by SEREX were measured in 33 ALS patients and 30 normal controls (NCs) by AlphaLISA using recombinant non-full-length proteins. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.09.013DOI Listing
December 2018
10 Reads

The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function.

J Neuroimmunol 2018 Dec 23;325:43-53. Epub 2018 Oct 23.

Division of Immunology, Transplantation and Infectious Disease, San Raffaele Hospital & Scientific Institute Milan, Italy. Electronic address:

Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.10.010DOI Listing
December 2018
1 Read

The role of expression and activity of 15-Lipoxygenase isoforms and related cytokines in patients with Multiple Sclerosis and healthy controls.

J Neuroimmunol 2018 Dec 18;325:32-42. Epub 2018 Oct 18.

Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Multiple Sclerosis (MS) as an inflammatory multifactorial auto immune nervous system disease imposes devastating burden of morbidity worldwide. Among environmental and genetic factors, the relevance of inflammatory mediators in MS pathogenesis is well documented. 15-Lipoxygense enzyme and its derived products have received attention as possible mediators of inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.10.009DOI Listing
December 2018
11 Reads

Confusional state in a pregnant woman: A case of NMDA receptor encephalitis during pregnancy.

J Neuroimmunol 2018 Dec 19;325:29-31. Epub 2018 Oct 19.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

We report the case of a pregnant female presenting with behavioral change and hallucinations followed by focal seizures with impaired awareness. EEG revealed generalized slowing interspersed with extreme delta-brush pattern and MRI brain was normal. Both Serum and CSF anti-N-methyl-d-aspartate receptor (NMDAR) antibodies were positive. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.10.008DOI Listing
December 2018
4 Reads
2.470 Impact Factor