7,309 results match your criteria Journal of Neuroimmunology[Journal]


Anti-glutamic acid decarboxylase (GAD) positive cerebellar Ataxia with transitioning to progressive encephalomyelitis with rigidity and myoclonus (PERM), responsive to immunotherapy: A case report and review of literature.

J Neuroimmunol 2019 Apr 6;332:135-137. Epub 2019 Apr 6.

University of Texas Medical Branch, Department of Neurology, 301 University Blvd, Galveston, TX 77555, USA. Electronic address:

We present a case of a 65-year-old African American male, immunosuppressed on Tacrolimus, who initially presented with cerebellar ataxia and rapidly developed Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with positive anti-glutamic acid decarboxylase (GAD65) antibodies, no underlying malignancy, and normal neuroimaging. PERM is a rare spectrum of Stiff Person Syndrome (SPS), which is strongly associated with anti-GAD antibodies and characterized by flare-ups and remissions of encephalopathy, myelopathy and rigidity with myoclonus. PERM is diagnosed clinically and has been successfully treated with both Intravenous Immunoglobulin (IVIg) and plasmapheresis. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.003DOI Listing

Efficacy and tolerability of mitoxantrone for neuromyelitis optica spectrum disorder: A systematic review.

J Neuroimmunol 2019 Apr 15;332:126-134. Epub 2019 Apr 15.

Department of Neurosciences, University of the Philippines Manila-Philippine General Hospital, Philippines.

The review assessed the efficacy and tolerability of mitoxantrone in patients with neuromyelitis optica spectrum disorder (NMOSD). Eight articles were reviewed with a total of 117 patients. Annualized relapse rate and progression of disability dramatically decreased post-treatment in most studies. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.007DOI Listing

The immunological response to traumatic brain injury.

J Neuroimmunol 2019 Apr 11;332:112-125. Epub 2019 Apr 11.

Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK.

Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the developed world. The accuracy of early outcome-prediction remains poor even when all known prognostic factors are considered, suggesting important currently unidentified variables. In addition, whilst survival and neurological outcomes have improved markedly with the utilisation of therapies that optimise physiology, no treatments specifically modulate the underlying pathophysiology. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.005DOI Listing
April 2019
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Interaction of neurotransmitters and neurochemicals with lymphocytes.

J Neuroimmunol 2019 Apr 11;332:99-111. Epub 2019 Apr 11.

The University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Brisbane, Australia; Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia. Electronic address:

Neurotransmitters and neurochemicals can act on lymphocytes by binding to receptors expressed by lymphocytes. This review describes lymphocyte expression of receptors for a selection of neurotransmitters and neurochemicals, the anatomical locations where lymphocytes can interact with neurotransmitters, and the effects of the neurotransmitters on lymphocyte function. Implications for health and disease are also discussed. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.006DOI Listing
April 2019
1 Read

Clinical characteristics of autoimmune GFAP astrocytopathy.

J Neuroimmunol 2019 Apr 9;332:91-98. Epub 2019 Apr 9.

Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan.

The clinical features of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy remain to be elucidated. We describe here the clinical features of 14 patients with GFAP astrocytopathy confirmed by detection of GFAP-IgG in cerebrospinal fluid (CSF). The novel findings of this study are as follows. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.004DOI Listing
April 2019
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The PD-1/PD-Ls pathway is up-regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides.

J Neuroimmunol 2019 Apr 1;332:78-90. Epub 2019 Apr 1.

Yue-yang Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address:

Multiple sclerosis (MS) is an inflammatory demyelinating disease of CNS. Astragalus polysaccharides (APS), the main active extract from astragalus membranaceus which is a kind of traditional Chinese medicinal herb, is associated with a variety of immunomodulatory activities. We have evaluated the therapeutic effects of APS in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183049
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http://dx.doi.org/10.1016/j.jneuroim.2019.03.019DOI Listing
April 2019
3 Reads

An investigation into the immune response of cultured neural rat cells following Zika virus infection.

J Neuroimmunol 2019 Apr 3;332:73-77. Epub 2019 Apr 3.

University of Delaware, Department of Psychological and Brain Sciences, 108 Wolf Hall, Newark, DE 19716, USA. Electronic address:

The most notable effect of prenatal Zika virus (ZIKV) infection is severe microcephaly. ZIKV has a selective tropism for neural progenitor cells; however, it is not clear what role the immune cells of the brain, microglia, may have in mitigating or exacerbating neuronal cell death following ZIKV infection. We cultured hippocampal and cortical neural cells from neonatal rat pups and infected them with ZIKV at various multiplicities of infection (MOI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183034
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http://dx.doi.org/10.1016/j.jneuroim.2019.04.002DOI Listing
April 2019
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False-positive acetylcholine receptor antibody results in patients without myasthenia gravis.

J Neuroimmunol 2019 Apr 3;332:69-72. Epub 2019 Apr 3.

Nuffield Department of Clinical Neurosciences,West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two patients had transiently raised AChR antibodies associated with Guillain-Barré syndrome. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.04.001DOI Listing
April 2019
2 Reads

A review of EEG in anti-NMDA receptor encephalitis.

J Neuroimmunol 2019 Mar 18;332:64-68. Epub 2019 Mar 18.

Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, United States of America.

Anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is common among autoimmune encephalitides (AE) and can present with protean features and nonspecific laboratory and neuroimaging results. Antibody testing is specific, but results are often delayed, and prompt diagnosis and treatment is vital given associated morbidity and mortality. Electroencephalography (EEG) may be a useful tool given ease of performance and short turn-around time for results. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.010DOI Listing
March 2019
2 Reads

Dopamine inhibits human CD8+ Treg function through D-like dopaminergic receptors.

J Neuroimmunol 2019 Mar 9. Epub 2019 Mar 9.

Center for Research in Medical Pharmacology, University of Insubria, Varese, Italy. Electronic address:

CD8+ T regulatory/suppressor cells (Treg) affect peripheral tolerance and may be involved in autoimmune diseases as well as in cancer. In view of our previous data showing the ability of DA to affect adaptive immune responses, we investigated the dopaminergic phenotype of human CD8+ Treg as well as the ability of DA to affect their generation and activity. Results show that CD8+ T cells express both D-like and D-like dopaminergic receptors (DR), tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of DA, and vesicular monoamine transporter (VMAT) 2 and contain high levels of intracellular DA. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.007DOI Listing
March 2019
1 Read

The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy.

J Neuroimmunol 2019 Mar 29;332:57-63. Epub 2019 Mar 29.

Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology CePT, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.

In our study, we assessed the potency of the brain-derived proteins ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), matrix metalloproteinase 9 (MMP-9), glial fibrillary acidic protein (GFAP) and the immune activation indicators interleukin 1β (IL-1β) and interleukin 6 (IL-6) as peripheral biomarkers of different susceptibilities to kindling in a preclinical model. We observed increased plasma UCH-L1 levels in kindled vs. control animals. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.018DOI Listing
March 2019
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T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model.

J Neuroimmunol 2019 Mar 23;332:49-56. Epub 2019 Mar 23.

Department of Oncology and Hematology, BMT with Section Pneumology, Hubertus Wald Tumorzentrum / UCCH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Haematology and Oncology, University Hospital Halle (Saale), Halle (Saale), Germany. Electronic address:

The experimental autoimmune encephalomyelitis (EAE) model is indispensable for autoimmunity research, but model-specific T cell dynamics are sparsely studied. We used next-generation immunosequencing across lymphoid organs, blood and spinal cord in response to immunization with myelin basic protein (MBP) to study T cell repertoires and migration patterns. Surprisingly, most spinal cord T cells were unique to the individual animal despite the existence of shared MBP-specific clones, suggesting a previously underestimated T cell diversity. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.014DOI Listing

Mechanism underlying β2-AR agonist-mediated phenotypic conversion of LPS-activated microglial cells.

J Neuroimmunol 2019 Mar 28;332:37-48. Epub 2019 Mar 28.

Departments of Dentistry, Medical Microbiology and Immunology, and Neuroscience, Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Fundamentally, microglia have two activation states, a pro-inflammatory neurotoxic (M1) and an anti-inflammatory neuroprotective (M2) phenotype, and their conversion from M1-like to M2-like microglia may provide therapeutic benefits to prevent neuronal loss in neurodegenerative diseases such as Parkinson's disease (PD). Previously, we showed that Salmeterol, a long-acting β2-adrenergic receptor (β2-AR) agonist, has neuroprotective effects in PD models in vitro and in vivo through the β-arrestin2-dependent inhibition of pro-inflammatory M1-type mediator production. In the present study, we explored whether Salmeterol can mediate phenotypic conversion in LPS-activated murine microglial BV2 cells from the neurotoxic M1-like to a neuroprotective M2-like phenotype. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.017DOI Listing

Corrigendum to: "low and high doses of ursolic acid ameliorate experimental autoimmune myasthenia gravis through different pathways" [Journal of Neuroimmunology 281 (2015) 61-67].

J Neuroimmunol 2019 May;330:181-183

Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.016DOI Listing
May 2019
2 Reads

Measurement of sCD27 in the cerebrospinal fluid identifies patients with neuroinflammatory disease.

J Neuroimmunol 2019 Mar 25;332:31-36. Epub 2019 Mar 25.

Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden. Electronic address:

Background: Laboratory tests to assist in the diagnosis and monitoring of neuroinflammatory diseases are scarce. The soluble form of the CD27 molecule (sCD27) is shed in high concentrations by activated T cells and can be detected in the cerebrospinal fluid. The aim of this study was to investigate whether CSF quantitation of sCD27 could discriminate between inflammatory and non-inflammatory neurological diseases. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.015DOI Listing
March 2019
2 Reads

Toll-like receptors in the pathogenesis of neuroinflammation.

Authors:
V Kumar

J Neuroimmunol 2019 Mar 20;332:16-30. Epub 2019 Mar 20.

Children Health Clinical Unit, School of Clinical Medicine, Faculty of Medicine, Mater Research, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia. Electronic address:

Toll-like receptors (TLRs) are discovered as crucial pattern recognition receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns (PAMPs). Later studies showed their involvement in the recognition of various damage/danger-associated molecular patterns (DAMPs) generated by host itself. Thus, TLRs are capable of recognizing wide-array of patterns/molecules derived from pathogens and host as well and initiating a proinflammatory immune response through the activation of NF-κB and other transcription factors causing synthesis of proinflammatory molecules. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.012DOI Listing
March 2019
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A CD40 targeting peptide prevents severe symptoms in experimental autoimmune encephalomyelitis.

J Neuroimmunol 2019 Mar 21;332:8-15. Epub 2019 Mar 21.

Webb-Waring Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address:

CD40/CD154-interaction is critical in the development of Experimental Autoimmune Encephalomyelitis (EAE; mouse model of Multiple Sclerosis). Culprit CD4CD40 T cells drive a more severe form of EAE than conventional CD4 T cells. Blocking CD40/CD154-interaction with CD154-antibody prevents or ameliorates disease but had thrombotic complications in clinical trials. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.013DOI Listing
March 2019
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Anti-NMDAR encephalitis preceded by non-herpetic central nervous system infection: Systematic literature review and first case of tick-borne encephalitis triggering anti-NMDAR encephalitis.

J Neuroimmunol 2019 Mar 19;332:1-7. Epub 2019 Mar 19.

Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Italy; Neuroimmunology group, Pediatric Research Institute "Città della Speranza", Padova, Italy.

After the recent description of biphasic disease with herpes simplex virus (HSV) encephalitis followed by anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE), anti-NMDARE preceded by non-HSV central nervous system (CNS) infection has been more rarely reported. We report the first case of TBE followed by anti-NMDARE and carry out a systematic literature review on anti-NMDARE preceded by non-HSV CNS infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728193006
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http://dx.doi.org/10.1016/j.jneuroim.2019.03.011DOI Listing
March 2019
4 Reads

The role of vitamin D and P2X7R in multiple sclerosis.

J Neuroimmunol 2019 May 14;330:159-169. Epub 2019 Mar 14.

Department of Physiology, The University of Melbourne, Melbourne, Australia; Department of Neuroscience, Monash University, Melbourne, Australia; Department of Neurology, Melbourne Health, Melbourne, Australia. Electronic address:

Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.004DOI Listing
May 2019
1 Read
2.467 Impact Factor

Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review.

J Neuroimmunol 2019 May 13;330:155-158. Epub 2019 Mar 13.

Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Anti-Homer-3 antibody associated cerebellar ataxia is a rare autoimmune cerebellar ataxia, which had been previously reported in 2 cases only. Here we present the third case where a middle-aged female experienced progressive cerebellar ataxia. A novel cerebellar ataxia antibody panel indicated sera of the patient was positive for anti-Homer-3 antibodies and established the diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183050
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http://dx.doi.org/10.1016/j.jneuroim.2019.01.002DOI Listing
May 2019
9 Reads
2.467 Impact Factor

Neuromyelitis optica after splenectomy: A secondary autoimmune phenomenon.

J Neuroimmunol 2019 May 11;330:152-154. Epub 2019 Mar 11.

Massachusetts General Hospital, Department of Neurology, 165 Cambridge St., Boston, MA 02114, USA. Electronic address:

We describe the case of a 53-year-old woman who undergoes total splenectomy and later presents with aquaporin-4 antibody positive neuromyelitis optica (NMO). The occurrence of NMO after acquired immunosuppression raises the possibility of NMO as a form of secondary autoimmunity. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.008DOI Listing

2'-Hydroxy-5'-methoxyacetophenone attenuates the inflammatory response in LPS-induced BV-2 and RAW264.7 cells via NF-κB signaling pathway.

J Neuroimmunol 2019 May 12;330:143-151. Epub 2019 Mar 12.

School of Chemistry and Environment of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China; Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China. Electronic address:

Seahorse has been used as a traditional medicine in Southeast Asian countries for a long time. A compound, 2'-Hydroxy-5'-Methoxyacetophenone (2H5M) isolated from seahorse, Hippocampus kuda, was tested for its anti-inflammatory effect in lipopolysaccharides (LPS)-stimulated BV-2 cells and RAW264.7 cells. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.009DOI Listing
May 2019
1 Read
2.467 Impact Factor

Clinical characteristics of patients with paraneoplastic myelopathy.

J Neuroimmunol 2019 May 1;330:136-142. Epub 2019 Mar 1.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China. Electronic address:

Paraneoplastic myelopathy is rare paraneoplastic neurological syndromes. We reviewed patients through medical records system and screened patients who presented with myelopathy, and/or coexisting cancer, and/or onconeural antibodies. Nine patients were identified as paraneoplastic myelopathy presenting with progressive subacute (2/9) or insidious (7/9) myelopathy. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.001DOI Listing
May 2019
2 Reads

Association of circulating anti-CD64 IgM levels with favourable long-term clinical outcomes in multiple sclerosis patients.

J Neuroimmunol 2019 May 8;330:130-135. Epub 2019 Mar 8.

Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

Circulating levels of IgM anti-CD64, an immunosuppressive antibody recently identified in long-term stable multiple sclerosis (MS) patients, were found to fluctuate over time in MS patients. Antibody-positive patients showed a significantly lower annualized relapse rate value as well as reached sustained disability worsening and had a relapse in a significantly longer median time than those without antibody. Disease-modifying therapies (DMTs) only were the covariate influencing both the relapse occurrence and the disability accrual. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.005DOI Listing
May 2019
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The association of rs703842 variants in CYP27B1 with multiple sclerosis susceptibility is influenced by the HLA-DRB1*15:01 allele in Slovaks.

J Neuroimmunol 2019 May 8;330:123-129. Epub 2019 Mar 8.

Department of Medical Biochemistry and BioMed, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic. Electronic address:

In this study, we analysed the association of rs703842 in CYP27B1 gene with multiple sclerosis (MS) risk and disability progression in a group of 496 MS patients and 521 controls. For the first time in Central European Slovak population, we found the rs703842 allele C to be protective factor against MS development (p = 1.09 × 10). Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.006DOI Listing
May 2019
2 Reads

Prognostic value of copeptin in patients with aneurysmal subarachnoid hemorrhage.

Authors:
Zhizhi Zuo Xiang Ji

J Neuroimmunol 2019 May 8;330:116-122. Epub 2019 Mar 8.

Emergency Department, Tianjin Huanhu Hospital, Tianjin 300350, PR China. Electronic address:

Background: Recently, copeptin has been identified as a plasma prognosis marker in acute ischemic stroke and intracerebral hemorrhage (ICH). This study investigated the prognostic value of copeptin in the patients with aneurysmal subarachnoid hemorrhage(aSAH).

Methods: In this retrospective study, 243 consecutive patients were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728193010
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http://dx.doi.org/10.1016/j.jneuroim.2019.03.007DOI Listing
May 2019
4 Reads

A combination of indomethacin and atorvastatin ameliorates cognitive and pathological deterioration in PrP-hAβPPswe/PS1 transgenic mice.

J Neuroimmunol 2019 May 6;330:108-115. Epub 2019 Mar 6.

Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China. Electronic address:

Mounting evidence has shown that inflammation might drive Alzheimer's disease (AD) pathology and contribute to its exacerbation. Previous studies have indicated that indomethacin or atorvastatin are beneficial in treating AD; however, no significant clinical effects have been shown. Furthermore, no study has investigated the efficacy of combining these agents for treating AD. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.003DOI Listing
May 2019
16 Reads

Effect of cornel iridoid glycoside on microglia activation through suppression of the JAK/STAT signalling pathway.

J Neuroimmunol 2019 May 4;330:96-107. Epub 2019 Mar 4.

Xuan Wu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, China. Electronic address:

The effect of cornel iridoid glycoside (CIG), main component extracted from Cornus officinalis, on microglia activation has not been elucidated so far. We induced a mouse model of multiple sclerosis (MS), namely, the experimental autoimmune encephalomyelitis (EAE) model by immunization subcutaneously with the MOG peptide, which causes neuroinflammation and microglia activation. Our data demonstrated that CIG delayed the onset of the EAE, ameliorated the severity of the symptoms and inhibited the activation of microglia in different brain regions. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.014DOI Listing
May 2019
6 Reads

Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation.

J Neuroimmunol 2019 May 2;330:90-95. Epub 2019 Mar 2.

Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461219PMC
May 2019
3 Reads

Serum Creatine Kinase in Patients with Neuromyelitis Optica Spectrum Disorder.

J Neuroimmunol 2019 May 23;330:87-89. Epub 2018 Dec 23.

Wayne State University, Detroit Medical Center, Detroit, USA.

Objectives: There have been reports of elevated serum creatine kinase (CK) and myopathy in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). Such findings have raised the possibility that myopathies may be a part of the spectrum of NMOSD. The incidence of elevated CK in NMOSD remains unknown. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2018.12.008DOI Listing
May 2019
1 Read

Reduced dosage rituximab in the treatment of anti-N-methyl-d-aspartate receptor encephalitis: An observation study in Chinese patients.

J Neuroimmunol 2019 May 18;330:81-86. Epub 2019 Feb 18.

Department of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; Institute of Neurology, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China. Electronic address:

The aim of this study was to observe the treatment effect and investigate the possible mechanism of reduced dosage (600 mg) rituximab treatment on anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. The median modified Rankin Scale of ten enrolled patients decreased from 4 (range 2-4) before rituximab infusion to 0 (range 0-2) after a mean follow-up time of 24.3 ± 8. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.008DOI Listing
May 2019
5 Reads

Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease?

J Neuroimmunol 2019 May 23;330:74-80. Epub 2019 Feb 23.

Graduate Progam in Neurology (PPGNEURO), Hospital Universitário Gaffrée e Guinle (HUGG), Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Rio de Janeiro/RJ 20270-004, Brazil; Department of Neurology, Hospital da Lagoa, Ministry of Health, Rua Jardim Botânico 501, Rio de Janeiro/RJ 22470-050, Brazil.

Background: The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population.

Methods: Association analyses between DR15 and the clinical and demographic variables were made. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.004DOI Listing
May 2019
1 Read

γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis.

J Neuroimmunol 2019 May 18;330:67-73. Epub 2019 Feb 18.

Chair and Department of Clinical Immunology, Medical University of Lublin, Poland.

The aim of the current review is to summarize the results of studies on the role of γδ T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of γδ T is still not fully understood. It seems that there are two distinct subpopulations - one exacerbating the disease (IL-17-producing) and the other playing a protective role (IFN-γ-secreting). Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.009DOI Listing

Elevated resistin levels may regulate high mobility group box 1 expression in Guillain-Barré syndrome.

J Neuroimmunol 2019 May 26;330:59-66. Epub 2019 Feb 26.

Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:

Interactions among cytokines have important roles in the inflammatory processes underlying Guillain-Barré syndrome (GBS). Resistin and high mobility group box 1 (HMGB1) are involved in many inflammatory processes. This study examined 51 GBS patients, and found that serum resistin levels were elevated in 51 patients with GBS and correlated with HMGB1 levels. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.011DOI Listing
May 2019
5 Reads
2.467 Impact Factor

Tacrolimus-induced severe headache associated with diffuse leukoencephalopathy: Evidence for an immune-mediated pathogenesis.

J Neuroimmunol 2019 May 21;330:55-58. Epub 2019 Feb 21.

Clinical Neurology Unit, Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia, 15, 33100, Udine, Italy; Department of Medicine, University of Udine Medical School, Udine 33100, Italy. Electronic address:

Tacrolimus-induced encephalopathy presents with acute neurological symptoms such as headache, seizures, visual disturbances, hemiplegia, and altered mental status. A 60-year-old woman, presented to our clinic with a 4-month history of severe headache. She recently underwent kidney transplantation and was taking tacrolimus. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.006DOI Listing
May 2019
2 Reads

A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage.

J Neuroimmunol 2019 May 22;330:48-54. Epub 2019 Feb 22.

Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan. Electronic address:

Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH). Here we show that a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH. Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.010DOI Listing
May 2019
2 Reads

Electroclinical insights into autoimmune epilepsy.

J Neuroimmunol 2019 May 15;330:44-47. Epub 2019 Feb 15.

Mater Advanced Epilepsy Unit, Mater Hospital, Brisbane, Australia.

Purpose: Chronic autoimmune epilepsy is an increasingly recognised entity however its clinical and electrographic features remain poorly understood. We present a case undergoing diagnostic Stereo-electroencephalography implantation that was found to have a multifocal perisylvian epilepsy with unique electrographic features and is now seizure free with immunotherapy.

Methods: The patient had antibody negative refractory perisylvian epilepsy and underwent implantation of the perisylvian-temporal networks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728193000
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http://dx.doi.org/10.1016/j.jneuroim.2019.02.005DOI Listing
May 2019
3 Reads

Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis.

J Neuroimmunol 2019 May 13;330:38-43. Epub 2019 Feb 13.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Hypertrophic pachymeningitis (HP) is a rare neurologic disease causing inflammatory fibrous thickening of the brain and spinal dura mater. We investigated the cerebrospinal fluid cytokine profile of HP by measuring 28 cytokines/chemokines/growth factors with a multiplexed fluorescent immunoassay in 8 patients with HP (6 idiopathic, 1 IgG4-related, 1 anti-neutrophil cytoplasmic antibody-related), and 11 with other non-inflammatory neurologic diseases (OND). Interleukin (IL)-4, IL-5, IL-9, IL-10, TNF-α, and CXCL8/IL-8 levels were significantly higher in idiopathic HP (IHP) than OND. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.010DOI Listing
May 2019
3 Reads

A case of treatable dementia with Lewy bodies remarkably improved by immunotherapy.

Authors:
Kie Abe Yuhei Chiba

J Neuroimmunol 2019 May 16;330:35-37. Epub 2019 Feb 16.

Department of Psychiatry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama-Shi, Kanagawa-Ken 236-0004, Japan. Electronic address:

We report a case of probable dementia with Lewy bodies (DLB) with several findings indicating autoimmune encephalitis (e.g. anti-thyroid antibodies in serum and oligoclonal band and anti-N-methyl-d-aspartic acid receptor antibodies in cerebrospinal fluid). Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.003DOI Listing
May 2019
3 Reads

Angiopoietin-like proteins in multiple sclerosis.

J Neuroimmunol 2019 May 15;330:31-34. Epub 2019 Feb 15.

Division of Neurology, Department of Medicine, Amiri Hospital, Kuwait.

Angiopoietin-like proteins (ANGPTLs) are a group of proteins with functions in lipid metabolism, angiogenesis, and inflammation. Here, we investigated their involvement in multiple sclerosis (MS) progression and response to treatment in 100 MS patients and 77 healthy controls. ANGPTLs significantly associated with MS progression and response to therapy. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.006DOI Listing
May 2019
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2.467 Impact Factor

Overcoming trivialization: The neuroimmune response after acute central nervous system injury.

J Neuroimmunol 2019 May 31;330:28-30. Epub 2019 Jan 31.

Department of Neurology, University Hospital Essen, 45147 Essen, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01655728183055
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http://dx.doi.org/10.1016/j.jneuroim.2019.01.018DOI Listing
May 2019
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IVIG efficacy in CIDP patients is not associated with terminal complement inhibition.

J Neuroimmunol 2019 May 10;330:23-27. Epub 2019 Feb 10.

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster 48149, Germany; Institute of Experimental Immunology, Department of Neuroinflammation, University of Zurich, Zürich 8057, Switzerland. Electronic address:

Patients with acute and chronic inflammatory demyelinating neuropathies exhibit elevated serum and cerebrospinal fluid (CSF) levels of terminal complement activation products and therapeutic inhibition of complement activation is currently tested for its safety and efficacy in patients with Guillain-Barré syndrome (GBS). Here, we determined serum levels of the complement activation products C3a, C5a and the soluble terminal complement complex (sTCC) in 39 individuals with chronic inflammatory demyelinating polyneuropathy (CIDP) who participated in one of the largest ever conducted clinical trial in patients with CIDP (ICE trial) and received Intravenous Immunoglobulin (IVIG) or placebo (albumin) in 3 week intervals for up to 24 weeks. In placebo-treated patients with spontaneous disease remission, serum sTCC levels moderately decreased over time. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.001DOI Listing
May 2019
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Pontine hemorrhage accompanied by neuromyelitis optica spectrum disorder.

J Neuroimmunol 2019 May 1;330:19-22. Epub 2019 Feb 1.

Department of Neurology, Juntendo University Faculty of Medicine, Japan.

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder caused by antibody to aquaporin-4 (AQP4). NMOSD can infrequently present as a complication of posterior reversible encephalopathy syndrome (PRES). Moreover, few cases of NMOSD patients with brain hemorrhage have been reported. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.020DOI Listing
May 2019
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The expansion of circulating IL-6 and IL-17-secreting follicular helper T cells is associated with neurological disabilities in neuromyelitis optica spectrum disorders.

J Neuroimmunol 2019 May 25;330:12-18. Epub 2019 Jan 25.

Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Microbiology, Immunology and Parasitology, Rio de Janeiro State University, Rio de Janeiro, Brazil; Departament of Neurology, Federal University of the State of Rio de Janeiro, Brazil. Electronic address:

Due to their function in assisting B cells, T cells may be involved in the production of pathogenic IgG in neuromyelitis optica spectrum disorder (NMOSD). In the present study, the proportion of IL-6 and IL-17 T cell subsets was higher in NMOSD patients than healthy individuals. The frequency of both T cell subsets were directly associated with disease activity. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.015DOI Listing
May 2019
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T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes.

J Neuroimmunol 2019 May 7;330:5-11. Epub 2019 Feb 7.

Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, USA.

Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.02.002DOI Listing
May 2019
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Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis.

J Neuroimmunol 2019 May 23;330:174-177. Epub 2019 Jan 23.

Juntendo University, Department of Neurology, Tokyo, Japan; Juntendo University, Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable disease, Tokyo, Japan.

Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease in ruminants, has been linked as a possible risk factor for human multiple sclerosis. In the current study we investigated the adjuvant effect of MAP on experimental autoimmune encephalomyelitis (EAE). Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.013DOI Listing
May 2019
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Atypical presentation of fulminant primary central nervous system angiitis.

J Neuroimmunol 2019 May 1;330:1-4. Epub 2019 Feb 1.

Department of Critical Care Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada. Electronic address:

Background: Primary Angiitis of the Central Nervous System (PACNS) is a rare cause of CNS vasculitis that should be included as part complete differential diagnosis, especially in cases with suggestive imaging findings and an absence of secondary causes for CNS vasculitis.

Case Presentation: We describe a case of a 47-year-old previously healthy Caucasian male presenting with rapid progression of encephalopathy and fevers. Extensive infectious, autoimmune, and imaging workups were unrevealing. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.019DOI Listing
May 2019
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Tongue tremor in neurofascin-155 IgG4 seropositive chronic inflammatory polyradiculoneuropathy.

J Neuroimmunol 2019 May 29;330:178-180. Epub 2019 Jan 29.

Laboratory of Neuroimmunology, IRCCS Mondino Foundation, Pavia, Italy.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with anti-neurofascin-155 antibodies is a subgroup of CIDP with tremor and poor response to intravenous immunoglobulins. A 23-year-old male presented with a 6-month history ataxic-stepping gait, stocking tactile hypoesthesia, areflexia, tremor at limbs and tongue. Neurophysiology and cerebrospinal fluid analysis supported the diagnosis of CIDP. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.017DOI Listing
May 2019
3 Reads

WITHDRAWN: Corrigendum to "Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway" [J. Neuroimmunol. 299 (2016) 164-171].

J Neuroimmunol 2019 02;327:44

Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.016DOI Listing
February 2019
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Muscarinic acetylcholine receptor expression in brain and immune cells of Oreochromis niloticus.

J Neuroimmunol 2019 Mar 22;328:105-107. Epub 2019 Jan 22.

Universidad Autónoma de Nayarit, Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Boulevard Tepic-Xalisco s/n. Cd, de la Cultura Amado Nervo, C.P. 63000 Tepic, Nayarit, Mexico; Centro Nayarita de Innovación y Transferencia de Tecnología A.C., Laboratorio Nacional para la Investigación en Inocuidad Alimentaria-Unidad Nayarit, Calle Tres s/n. Cd Industrial, Tepic, Nayarit, Mexico. Electronic address:

Nervous and immune systems maintain a bidirectional communication, expressing receptors for neurotransmitters and cytokines. Despite being well established in mammals, this has been poorly described in lower vertebrates as fishes. Experimental evidence shows that the neurotransmitter acetylcholine (ACh) regulates the immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655728193001
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http://dx.doi.org/10.1016/j.jneuroim.2019.01.012DOI Listing
March 2019
10 Reads