2,050 results match your criteria Journal of Neuroimaging[Journal]


Thrombectomy of Ventricular Assist Device-Originated Embolic Stroke: A Clinical Decision Model.

J Neuroimaging 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Loyola University Chicago, Stritch School of Medicine.

Background And Purpose: The use of ventricular assist devices (VADs) for the treatment of heart failure has become increasingly common. These patients have a considerable risk of cerebral embolism. We describe such a patient and his successful treatment by thrombectomy, compare his attributes with those previously published, and describe the construct of a clinical decision model, whose results bear practical implications for patient management. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12621
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http://dx.doi.org/10.1111/jon.12621DOI Listing
April 2019
1 Read

Functional Neurosonology Reveals Impaired Cerebrovascular Reactivity in Multiple Sclerosis.

J Neuroimaging 2019 Apr 16. Epub 2019 Apr 16.

Second Department of Neurology, "Attikon" Hospital, School of Medicine , University of Athens, Greece.

Background And Purpose: Vascular aspects like global cerebral hypoperfusion are frequently reported in patients with multiple sclerosis (MS). Although mechanistic question remains unanswered, this hemodynamic impairment may be caused by a widespread endothelial dysfunction. Furthermore, impaired cerebrovascular reactivity (CVR) has been described in patients with MS by means of hypercapnic perfusion magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1111/jon.12617DOI Listing
April 2019
3 Reads

MRI Assessment of Oxygen Metabolism and Hemodynamic Status in Symptomatic Intracranial Atherosclerotic Stenosis: A Pilot Study.

J Neuroimaging 2019 Apr 4. Epub 2019 Apr 4.

Department of Neuroradiology, Hospices Civils de Lyon, Bron, France.

Background And Purpose: Hemodynamic and metabolic impairment in intracranial atherosclerotic stenosis (ICAS) may promote stroke vulnerability particularly in borderzone areas. Perfusion and oxygen mapping magnetic resonance imaging (MRI) may provide useful information in this setting.

Methods: In this pilot study, patients with symptomatic atherosclerotic anterior circulation stenosis ≥60%, without other sources of ischemic stroke, were included. Read More

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http://dx.doi.org/10.1111/jon.12615DOI Listing

Mapping a Reliable Stroke Onset Time Course Using Signal Intensity on DWI Scans.

J Neuroimaging 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurosciences, University of San Diego Health, Stroke Center, San Diego, CA.

Background And Purpose: Identifying a last known well (LKW) time surrogate for acute stroke is vital to increase stroke treatment. Diffusion-weighted imaging (DWI) signal intensity initially increases from onset of stroke but mapping a reliable time course to the signal intensity has not been demonstrated.

Methods: We retrospectively reviewed stroke code patients between 1/2016 and 6/2017 from the prospective; Institutional review board (IRB) approved University of California San Diego Stroke Registry. Read More

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http://dx.doi.org/10.1111/jon.12616DOI Listing
April 2019
3 Reads
1.818 Impact Factor

Neuroimaging of Pediatric Arteriopathies.

J Neuroimaging 2019 Mar 28. Epub 2019 Mar 28.

Department of Radiology, SUNY Upstate Medical University, Syracuse, NY.

Pediatric arteriopathies are increasingly recognized in school-aged children with a variety of presenting symptoms ranging from headache, seizures, encephalopathy, and neuropsychiatric symptoms as well as focal neurologic deficits due to acute ischemic strokes. However, unlike the adult stroke population, there are differences in the clinical manifestations, the stroke mechanism, and risk factors in pediatric ischemic stroke. There has been increasing awareness and recognition of pediatric cerebral arteriopathies as a predominant stroke etiology. Read More

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http://dx.doi.org/10.1111/jon.12614DOI Listing

The Addition of Atrial Fibrillation to the Los Angeles Motor Scale May Improve Prediction of Large Vessel Occlusion.

J Neuroimaging 2019 Mar 22. Epub 2019 Mar 22.

Departments of Neurology.

Background And Purpose: There is evidence suggesting that Los Angeles Motor Scale (LAMS) ≥ 4 predicts large vessel occlusion (LVO). We aim to determine whether atrial fibrillation (AF) can improve the ability of LAMS in predicting LVO.

Methods: We included consecutive patients with a discharge diagnosis of ischemic stroke admitted within 24 hours from last known normal time who underwent emergent vascular imaging using a computerized tomography angiography (CTA) of the head and neck. Read More

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http://dx.doi.org/10.1111/jon.12613DOI Listing
March 2019
2 Reads

The Impact of MRI T1 Hypointense Brain Lesions on Cerebral Deep Gray Matter Volume Measures in Multiple Sclerosis.

J Neuroimaging 2019 Mar 20. Epub 2019 Mar 20.

 Translational Cognitive Neuroscience Laboratory, Department of Neurology, Columbia University Irving Medical Center, New York, NY.

Background And Purpose: Deep gray matter (DGM) atrophy has been shown at early stages of multiple sclerosis (MS) and reported as an informative marker of cognitive dysfunction and clinical progression. Therefore, accurate measurement of DGM structure volume is a key priority in MS research. Findings from prior studies have shown that hypointense T1 lesions may impact the accuracy of global brain volume measures; however, literature on the effects of hypointense T1 lesions on DGM structure volumes is sparse. Read More

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http://dx.doi.org/10.1111/jon.12611DOI Listing
March 2019
1 Read
1.818 Impact Factor

Hemodynamic Differences Between Recurrent and Nonrecurrent Intracranial Aneurysms: Fluid Dynamics Simulations Based on MR Angiography.

J Neuroimaging 2019 Mar 20. Epub 2019 Mar 20.

Oxford Neurovascular & Neuroradiology Research Unit, Oxford Radcliffe Hospital, Oxford, UK.

Background And Purpose: Although the role of wall shear stress (WSS) in the initiation, growth, and rupture of intracranial aneurysms has been well studied, its influence on aneurysm recurrence after endovascular treatment requires further investigation. We aimed to compare WSS at necks of recurrent and nonrecurrent aneurysms.

Methods: Nine recurrent coil-embolized aneurysms were identified and matched with nine nonrecurrent aneurysms. Read More

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http://dx.doi.org/10.1111/jon.12612DOI Listing

Longitudinal Analysis of Quantitative Brain MRI in Astronauts Following Microgravity Exposure.

J Neuroimaging 2019 Feb 19. Epub 2019 Feb 19.

Department of Diagnostic and Intervention Imaging, University of Texas Health Science Center, Houston, TX.

Background And Purpose: Assessment of the effects of microgravity on astronauts' brains using microstructural measures by utilizing quantitative MRI, before and after spaceflight would help understand the structural changes.

Methods: Quantitative MRI data sets in 19 astronauts were acquired before and after space missions. Both diffusion tensor metrics and volumetric measures were analyzed in the brain regions involved in the visual function. Read More

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http://dx.doi.org/10.1111/jon.12609DOI Listing
February 2019
1 Read

CT Attenuation of Acute Subdural Hematomas in Patients with Anemia.

J Neuroimaging 2019 Feb 16. Epub 2019 Feb 16.

Diagnostic Radiology Department, Lahey Hospital and Medical Center, Burlington, MA.

Background And Purpose: Isodense and hypodense acute subdural hematomas have been reported in the literature in anemic patients. The purpose of this study is to see if there is a statistically significant difference between the Hounsfield unit measurements of acute subdural hematomas in anemic and nonanemic patients.

Methods: A total of 109 patients were analyzed. Read More

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http://dx.doi.org/10.1111/jon.12608DOI Listing
February 2019
11 Reads

Vessel Wall MRI Added to MR Angiography in the Evaluation of Suspected Vasculopathies.

J Neuroimaging 2019 Feb 13. Epub 2019 Feb 13.

Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Boston, MA.

Background And Purpose: We hypothesized that vessel wall MR imaging (VWI) with 3D-time-of-flight magnetic resonance imaging (3D-TOF-MRA) together increases the ability to detect abnormal intracranial vessel segments compared to 3D-TOF-MRA alone.

Methods: Ninety-three consecutive subjects with a clinical history of suspected vasculopathy imaged with both VWI and 3D-TOF-MRAs were retrospectively reviewed. The 3D-TOF-MRAs were reviewed by two independent neuroradiologists classifying arterial segments as normal or abnormal based on caliber changes. Read More

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http://dx.doi.org/10.1111/jon.12607DOI Listing
February 2019

Cerebrovascular Reactivity Impairment in Preclinical Alzheimer's Disease.

J Neuroimaging 2019 Feb 12. Epub 2019 Feb 12.

Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE.

Background And Purpose: A substantial overlap exists between declines in cerebral vasoreactivity (CVR) and symptomatic Alzheimer's disease (AD). CVR can be quantified using transcranial Doppler (TCD) measurement of cerebral blood flow velocities (CBFV) in the middle cerebral artery (MCA) with CO as a vasodilatory stimulus. The breath-hold acceleration index (BHAI) is a new, more reliable measure of CVR developed recently in our laboratory. Read More

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http://dx.doi.org/10.1111/jon.12606DOI Listing
February 2019
1 Read

Myelinating Proteins in MS Are Linked to Volumetric Brain MRI Changes.

J Neuroimaging 2019 Feb 12. Epub 2019 Feb 12.

 Departments of Neurology, University of Texas Health Science Center at Houston, Houston, TX.

Background And Purpose: There is evidence of a relationship between promyelinating proteins and clinical multiple sclerosis (MS) activity during clinical relapse or recovery from clinical relapses. We examined the linkage between promyelinating biomarkers and volumetric changes in MS subjects during serial magnetic resonance imaging (MRI).

Methods: We enrolled 13 MS subjects with active brain MRI scans not on disease modifying therapies. Read More

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http://doi.wiley.com/10.1111/jon.12605
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http://dx.doi.org/10.1111/jon.12605DOI Listing
February 2019
12 Reads

Ultrasonography Monitoring of Optic Nerve Sheath Diameter and Retinal Vessels in Patients with Cerebral Hemorrhage.

J Neuroimaging 2019 Feb 3. Epub 2019 Feb 3.

Department of Neurology, Saarland University Medical Center, Homburg, Germany.

Background And Purpose: Evaluation of the diagnostic accuracy of optic nerve sheath diameter (ONSD) and Doppler indices of central retinal arteries and veins for the detection of increased intracranial pressure (ICP) in intracerebral hemorrhage (ICH) and of the usefulness of a second assessment of these variables in the monitoring of ICH.

Methods: A total of 46 acute ICH patients with (group 1, n = 25) and without (group 2, n = 21) clinical and radiological computed tomography signs of raised ICP and 40 healthy controls were recruited. The median binocular ONSD and Doppler indices of retinal vessels including resistive index (RI) and retinal venous pulsation (RVP) were compared among groups, both at admission and later during ICH monitoring. Read More

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http://dx.doi.org/10.1111/jon.12604DOI Listing
February 2019
2 Reads

Adaptive Identification of Cortical and Subcortical Imaging Markers of Early Life Stress and Posttraumatic Stress Disorder.

J Neuroimaging 2019 Feb 3. Epub 2019 Feb 3.

Imaging Genetics Center of the Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA.

Background And Purpose: Posttraumatic stress disorder (PTSD) is a heterogeneous condition associated with a range of brain imaging abnormalities. Early life stress (ELS) contributes to this heterogeneity, but we do not know how a history of ELS influences traditionally defined brain signatures of PTSD. Here, we used a novel machine learning method - evolving partitions to improve classification (EPIC) - to identify shared and unique structural neuroimaging markers of ELS and PTSD in 97 combat-exposed military veterans. Read More

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http://dx.doi.org/10.1111/jon.12600DOI Listing
February 2019
1 Read

18F-Florbetaben PET/CT to Assess Alzheimer's Disease: A new Analysis Method for Regional Amyloid Quantification.

J Neuroimaging 2019 Feb 3. Epub 2019 Feb 3.

U.O.C. Neurologia, Fondazione IstitutoG. Giglio, Contrada Pietrapollastra-Pisciotto, 90015, Cefalù, Italy.

Background And Purpose: While AD can be definitively confirmed by postmortem histopathologic examination, in vivo imaging may improve the clinician's ability to identify AD at the earliest stage. The aim of the study was to test the performance of amyloid PET using new processing imaging algorithm for more precise diagnosis of AD.

Methods: Amyloid PET results using a new processing imaging algorithm (MRI-Less and AAL Atlas) were correlated with clinical, cognitive status, CSF analysis, and other imaging. Read More

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http://dx.doi.org/10.1111/jon.12601DOI Listing
February 2019
4 Reads

The Role of Transcranial Doppler Monitoring in Patients with Multi-Territory Acute Embolic Strokes: A Review.

J Neuroimaging 2019 Jan 31. Epub 2019 Jan 31.

Second Department of Neurology, National & Kapodistiran University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.

Acute multi-territory, embolic cerebral infarctions are often associated with serious underlying clinical conditions including the presence of highly "active" emboligenic sources causing that in turn may result in high early recurrence rates. Prompt diagnosis, risk stratification, and treatment are substantial for the prevention of subsequent embolization that would result in further clinical deterioration. Among other clinical investigations, transcranial Doppler (TCD) monitoring is highly efficacious for the detection of microembolic signals (MES) that correspond to microthrombi entering the intracranial circulation. Read More

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http://dx.doi.org/10.1111/jon.12602DOI Listing
January 2019
2 Reads

Variability of Resting-State Functional MRI Graph Theory Metrics across 3T Platforms.

J Neuroimaging 2019 Jan 31. Epub 2019 Jan 31.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA.

Background And Purpose: Graph theory analysis of brain connectivity data is a promising tool for studying the function of the healthy and diseased brain. The consistency of resting-state functional MRI (rsfMRI) connectivity measures across multiple scanner types is an important factor in designing multi-institutional research studies and has important implications for the potential use of this technique in a heterogeneous clinical setting. We sought to quantitatively study the interscanner variability of rsfMRI graph theory metrics obtained from healthy volunteers scanned on three different scanner platforms. Read More

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http://dx.doi.org/10.1111/jon.12603DOI Listing
January 2019
2 Reads

A Relative Noncontrast CT Map to Detect Early Ischemic Changes in Acute Stroke.

J Neuroimaging 2019 Mar 25;29(2):182-186. Epub 2019 Jan 25.

Stroke Center, Stanford University, Stanford, CA.

Background And Purpose: Early ischemic changes on noncontrast computed tomography (NCCT) are often subtle. We developed a novel postprocessing technique that aids in detecting such changes.

Methods: NCCT maps were generated that display the relative density difference between corresponding voxels in contralateral hemispheres (ratio maps of the NCCT [rNCCT]). Read More

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http://dx.doi.org/10.1111/jon.12593DOI Listing

The Role of CT Perfusion in Defining the Clinically Relevant Core Infarction to Guide Thrombectomy Selection in Patients with Acute Stroke.

J Neuroimaging 2019 Jan 20. Epub 2019 Jan 20.

Neuroscience Institute, Division of Neurology, Spectrum Health.

Background And Purpose: Infarct core assessment on presentation is important to evaluate salvageable tissue to select patients for thrombectomy. Our study aims to evaluate the correlation between infarct core volume measured by computed tomography (CT) perfusion (CTP) and magnetic resonance diffusion-weighted imaging (MR-DWI) in patients with acute large-vessel occlusion.

Methods: We studied patients who underwent CTP on presentation to the emergency department for stroke symptoms. Read More

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http://dx.doi.org/10.1111/jon.12599DOI Listing
January 2019
4 Reads

Functional MRI Task Comparison for Language Mapping in Neurosurgical Patients.

J Neuroimaging 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background And Purpose: Language task-based functional MRI (fMRI) is increasingly used for presurgical planning in patients with brain lesions. Different paradigms elicit activations of different components of the language network. The aim of this study is to optimize fMRI clinical usage by comparing the effectiveness of three language tasks for language lateralization and localization in a large group of patients with brain lesions. Read More

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http://doi.wiley.com/10.1111/jon.12597
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http://dx.doi.org/10.1111/jon.12597DOI Listing
January 2019
4 Reads

Accuracy of "At Risk" Tissue Predictions Using CT Perfusion in Acute Large Vessel Occlusions.

J Neuroimaging 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurology, UTHealth McGovern School of Medicine, Houston, TX.

Background And Purpose: The validity of CT perfusion (CTP) predictions of expected infarction volume ("at risk" tissue) without rapid recanalization remains poorly characterized.

Methods: From the MR CLEAN trial, we included patients who underwent CTP without successful recanalization. "At risk" volume was defined as T > 6 seconds and ischemic core as relative CBF < 30 (Olea Sphere). Read More

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http://doi.wiley.com/10.1111/jon.12595
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http://dx.doi.org/10.1111/jon.12595DOI Listing
January 2019
9 Reads

MRI Features Associated with TERT Promoter Mutation Status in Glioblastoma.

J Neuroimaging 2019 Jan 15. Epub 2019 Jan 15.

Department of Radiology, New York Presbyterian Hospital-Cornell, New York, NY.

Background And Purpose: Telomerase reverse transcriptase (TERT) promoter mutations are associated with worse prognosis in glioblastoma. The purpose of this study was to evaluate whether TERT mutation status was associated with specific morphologic and quantitative imaging features.

Methods: Twenty-nine patients with isocitrate dehydrogenase 1/2-wildtype glioblastoma (13 TERT-wildtype, 16 TERT-mutated), who underwent preoperative magnetic resonance (MR) imaging were included in this retrospective study. Read More

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http://dx.doi.org/10.1111/jon.12596DOI Listing
January 2019
2 Reads

Semiautomated Assessment of the Anterior Cingulate Cortex in Alzheimer's Disease.

J Neuroimaging 2019 Jan 14. Epub 2019 Jan 14.

Department of Anatomy & Cell Biology, Western University, London, ON, Canada.

Background And Purpose: The anterior cingulate cortex (ACC) is involved in several cognitive processes including executive function. Degenerative changes of ACC are consistently seen in Alzheimer's disease (AD). However, volumetric changes specific to the ACC in AD are not clear because of the difficulty in segmenting this region. Read More

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http://dx.doi.org/10.1111/jon.12598DOI Listing
January 2019
2 Reads

Cytotoxic Edema in Pediatric Abusive Head Trauma: Adopting a Common Nomenclature.

J Neuroimaging 2019 Mar 8;29(2):272-273. Epub 2019 Jan 8.

Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MD.

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http://doi.wiley.com/10.1111/jon.12594
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http://dx.doi.org/10.1111/jon.12594DOI Listing
March 2019
17 Reads

Neurosonography After Mechanical Thrombectomy for Acute Stroke Treatment.

J Neuroimaging 2019 Jan 2. Epub 2019 Jan 2.

Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, München, Germany.

Background And Purpose: Mechanical thrombectomy has been shown to be effective for acute stroke treatment, but lesions of cerebral vessels can develop thereafter. Such lesions of recanalized vessels and altered cerebral hemodynamics after mechanical thrombectomy are poorly investigated. In particular for neurosonography, data are sparse. Read More

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http://dx.doi.org/10.1111/jon.12592DOI Listing
January 2019
1 Read

Gray vs. White Matter Segmentation of the Conus Medullaris: Reliability and Variability in Healthy Volunteers.

J Neuroimaging 2018 Dec 24. Epub 2018 Dec 24.

NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom.

Background And Purpose: Magnetic resonance imaging (MRI)-derived spinal cord (SC) gray and white matter (GM/WM) volume are useful indirect measures of atrophy and neurodegeneration over time, typically obtained in the upper SC. Neuropathological evidence suggests that in certain neurological conditions, early degeneration may occur as low as the sacral SC. In this study, the feasibility of GM/WM segmentation of the conus medullaris (CM) was assessed in vivo. Read More

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http://dx.doi.org/10.1111/jon.12591DOI Listing
December 2018
6 Reads

Ultrasound-Derived Nerve Cross-Sectional Area in Extremes of Height and Weight.

J Neuroimaging 2018 Dec 24. Epub 2018 Dec 24.

Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC.

Background And Purpose: There is a lack of consensus in the literature as to which body habitus parameter most influences nerve cross-sectional area (CSA). This study was specifically designed to determine if height or weight is more influential.

Methods: Fifteen young healthy participants, 8 extremely tall and 7 heavy, with no peripheral nerve symptoms were recruited. Read More

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http://dx.doi.org/10.1111/jon.12590DOI Listing
December 2018
2 Reads

Patients with Mild Cognitive Impairment May be Stratified by Advanced Diffusion Metrics and Neurocognitive Testing.

J Neuroimaging 2019 Jan 11;29(1):79-84. Epub 2018 Dec 11.

Department of Neurology, Emory University, Atlanta, GA.

Background And Purpose: Mild cognitive impairment (MCI) is a prevalent disorder, with a subset of patients progressing to dementia each year. Although MCI may be subdivided into amnestic or vascular types as well as into single or multiple cognitive domain involvement, most prior studies using advanced diffusion imaging have not accounted for these categories. The purpose of the current study was to determine if the pattern of diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) metrics in patients with amnestic MCI (aMCI) correlate to specific cognitive domain impairments. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12588
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http://dx.doi.org/10.1111/jon.12588DOI Listing
January 2019
9 Reads

Brain MRI Lesions are Related to Bowel Incontinence in Multiple Sclerosis.

J Neuroimaging 2019 Mar 11;29(2):211-217. Epub 2018 Dec 11.

Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Background And Purpose: Bowel incontinence in multiple sclerosis might be associated with specific lesion sites. This study intended to determine associations between bowel incontinence and cerebral multiple sclerosis lesions using a voxel-wise lesion symptom mapping analysis.

Methods: We conducted a retrospective study of multiple sclerosis patients with self-reported bowel incontinence and matched controls. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12589
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http://dx.doi.org/10.1111/jon.12589DOI Listing
March 2019
13 Reads

The Efficacy of IV Tissue Plasminogen Activator for Restoring Cerebral Blood Flow in the Hours Immediately after Administration in Patients with Acute Stroke.

J Neuroimaging 2019 Mar 3;29(2):206-210. Epub 2018 Dec 3.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.

Background And Purpose: Timely restoration of tissue-level cerebral blood flow is the goal of thrombolytic therapy in patients presenting with an acute ischemic stroke. We aimed to identify the incidence and predictors of reperfusion immediately following treatment with intravenous recombinant tissue plasminogen activator (IV rt-PA).

Methods: This study included patients with acute ischemic stroke triaged using magnetic resonance imaging (MRI) with perfusion-weighted imaging (PWI) and treated with IV rt-PA who were subsequently enrolled in our natural history study and underwent repeat MRI with PWI approximately 2 hours posttreatment. Read More

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http://dx.doi.org/10.1111/jon.12587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403008PMC
March 2019
4 Reads

Brain Atrophy in Natalizumab-treated Patients with Multiple Sclerosis: A 5-year Retrospective Study.

J Neuroimaging 2019 Mar 28;29(2):190-192. Epub 2018 Nov 28.

Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Baden-Württemberg, Germany.

Background And Purpose: Studies demonstrated a higher brain volume loss in the first year after initiation of natalizumab treatment than in the second year, but the experiences beyond 24 months are scarce until now. We investigated the evolution of brain volume changes in multiple sclerosis (MS) patients receiving natalizumab for at least 60 months.

Methods: Using annual 3-dimensional magnetization-prepared rapid acquisition gradient-echo (MPRAGE) sequences acquired on a 3 Tesla magnetic resonance imaging (MRI), we investigated percentage brain volume changes (PBVCs) in 10 MS patients (9 women, mean age at baseline MRI = 29 ± 9 years; median Expanded Disability Status Scale = 2 ± 1. Read More

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http://dx.doi.org/10.1111/jon.12586DOI Listing
March 2019
1 Read

Ultrasound, Clinical, and Electrophysiological Findings in Persistent Carpal Tunnel Syndrome.

J Neuroimaging 2019 Mar 23;29(2):218-222. Epub 2018 Nov 23.

Department of Orthopedic Surgery, St. Luke's Hospital, Thessaloniki, Greece.

Background And Purpose: We present the clinical, electrophysiological, and nerve ultrasound findings in cases of persistent carpal tunnel syndrome (PCTS).

Methods: Eighteen PCTS patients underwent evaluation with the Boston Carpal Tunnel Syndrome Questionnaire (BCTSQ), electrophysiology, and nerve ultrasound with a mean of 3.5 months (SD ± 1. Read More

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http://doi.wiley.com/10.1111/jon.12585
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http://dx.doi.org/10.1111/jon.12585DOI Listing
March 2019
14 Reads

Impact of Intraoperative Hyperglycemia on Brain Structures and Volumes.

J Neuroimaging 2019 Mar 23;29(2):260-267. Epub 2018 Nov 23.

Pharmaimage Biomarker Solutions GmbH, Berlin, Germany.

Background And Purpose: In hyperglycemic patients, who succumbed to septic shock, an increased rate of apoptosis of microglial cells and damaged neurons of the hippocampus were found. However, the influence of perioperative glucose levels on hippocampal brain structures has not yet been investigated.

Methods: As part of the ongoing BIOCOG project, a subgroup of N = 65 elderly nondemented patients were analyzed who underwent elective surgery of ≥60 minutes. Read More

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http://dx.doi.org/10.1111/jon.12583DOI Listing
March 2019
17 Reads

Femoral Neuropathy Following Transfemoral Neuroendovascular Procedures. An Analysis of a Prospective Registry.

J Neuroimaging 2019 Mar 23;29(2):268-271. Epub 2018 Nov 23.

Department of Neurology, University of Illinois and Mercyhealth, Rockford, IL.

Background And Purpose: Although femoral neuropathy is recognized as an adverse consequence following transfemoral neuroendovascular procedures, no reliable estimates are available. We analyzed data from a prospective registry to ascertain the frequency and characteristics of femoral neuropathy following transfemoral neuroendovascular procedures.

Methods: Consecutive patients who underwent neuroendovascular procedures through the transfemoral route were included. Read More

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http://doi.wiley.com/10.1111/jon.12584
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http://dx.doi.org/10.1111/jon.12584DOI Listing
March 2019
18 Reads

Early Phase PIB-PET as a Surrogate for Global and Regional Cerebral Blood Flow Measures.

J Neuroimaging 2019 Jan 21;29(1):85-96. Epub 2018 Nov 21.

Department of Psychiatry, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA.

Background And Purpose: To explore the potential for simplified measures of [ C]PIB uptake to serve as a surrogate for cerebral blood flow (CBF) measures, thereby, providing both pathological and functional information in the same scan.

Methods: Participants (N = 24, 16 M, 8 F, 57-87 years) underwent quantitative [ O]water imaging and dynamic [ C]PIB imaging. Time-activity curves were created for each participant's regional [ C]PIB data scaled in standardized uptake values (SUVs). Read More

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http://dx.doi.org/10.1111/jon.12582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425949PMC
January 2019
19 Reads

Diffusion Tensor Imaging of the Superior Thalamic Radiation and Cerebrospinal Fluid Distribution in Idiopathic Normal Pressure Hydrocephalus.

J Neuroimaging 2019 Mar 20;29(2):242-251. Epub 2018 Nov 20.

Department of Neurology, McGovern Medical School, University of Texas Health Science Center (UTHSC), Houston, TX.

Background And Purpose: Ventricular enlargement in elderly raises a challenging differential diagnosis to physicians. While Alzheimer's disease is the most common form of dementia, idiopathic normal pressure hydrocephalus (iNPH) constitutes a potentially reversible syndrome. iNPH has a unique pathophysiology pertaining to cerebrospinal fluid (CSF) dynamics and periventricular white matter. Read More

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http://dx.doi.org/10.1111/jon.12581DOI Listing
March 2019
21 Reads

Simulation and Experimental Characterization of Lateral Imaging Resolution of Ultrasound Systems and Assessment of System Suitability for Acoustic Optic Nerve Sheath Diameter Measurement.

J Neuroimaging 2019 Jan 20;29(1):34-41. Epub 2018 Nov 20.

Hochschule für Technik und Wirtschaft des Saarlandes, Biomedical Engineering, Saarbrücken, Germany.

Background And Purpose: Optic nerve sheath diameter (ONSD) is used for the estimation of intracranial pressure (ICP). But there are still doubts about the quality of the images and the lateral resolution. Our aim is to investigate the system suitability and best lateral resolution of different ultrasound systems for acoustic ONSD measurement. Read More

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http://dx.doi.org/10.1111/jon.12578DOI Listing
January 2019
1 Read

Microvessels may Confound the "Swallow Tail Sign" in Normal Aged Midbrains: A Postmortem 7 T SW-MRI Study.

J Neuroimaging 2019 Jan 8;29(1):65-69. Epub 2018 Nov 8.

Department of Biomedical Imaging and Image-guided Therapy, High Field Magnetic Resonance Centre, Medical University of Vienna, Vienna, Austria.

Background And Purpose: Susceptibility weighted imaging (SWI) plays a role in the differential diagnosis of Parkinson's disease, but lacks widespread acceptance in clinical routine. In a descriptive pilot study, we assessed hypointense microstructures of the normal substantia nigra pars compacta at ultrahigh-field strength for interpretation of the "swallow tail sign."

Methods: Magnetic resonance imaging at 7 Tesla was performed in five postmortem samples obtained from subjects not affected by Parkinson's disease. Read More

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http://doi.wiley.com/10.1111/jon.12576
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January 2019
8 Reads

Clinical, Sonographic, and Electrophysiologic Longitudinal Features of Chronic Inflammatory Demyelinating Polyneuropathy.

J Neuroimaging 2019 Mar 8;29(2):223-232. Epub 2018 Nov 8.

Department of Neurology, Ruhr University Bochum, Bochum, Germany.

Background And Purpose: Several studies have aimed to find potential biomarkers to simplify the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) and to monitor and predict the disease course. However, reliable markers are still lacking. We aimed to investigate whether high-resolution nerve ultrasound (HRUS) is suitable for monitoring the long-term clinical course of CIDP. Read More

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http://doi.wiley.com/10.1111/jon.12579
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March 2019
12 Reads

What Threshold Defines Penumbral Brain Tissue in Patients with Symptomatic Anterior Circulation Intracranial Stenosis: An Exploratory Analysis.

J Neuroimaging 2019 Mar 6;29(2):203-205. Epub 2018 Nov 6.

 Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI.

Background And Purpose: Impaired distal perfusion predicts neurological deterioration in large artery atherosclerosis. We aim to determine the optimal threshold of Tmax delay on perfusion imaging that is associated with neurological deterioration in patients with symptomatic proximal anterior circulation large artery stenosis.

Methods: Data were abstracted from a prospective ischemic stroke database of consecutively enrolled patients with symptomatic proximal intracranial stenosis (internal carotid artery or M1 segment of the middle cerebral artery) who underwent magnetic resonance perfusion imaging within 24 hours of symptom onset during a 15-month period. Read More

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http://doi.wiley.com/10.1111/jon.12577
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March 2019
22 Reads

White Matter Microstructure Correlates with Memory Performance in Healthy Children: A Diffusion Tensor Imaging Study.

J Neuroimaging 2019 Mar 6;29(2):233-241. Epub 2018 Nov 6.

Arkansas Children's Nutrition Center, Little Rock, AR.

Background And Purpose: The complex function of memory has been linked to both brain gray and white matter (WM). WM abnormalities are associated with memory impairment in pathological conditions. We investigated whether variation in WM microstructure in healthy children also correlates with memory performance. Read More

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http://doi.wiley.com/10.1111/jon.12580
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March 2019
14 Reads

Dr. Leon D. Prockop (1934-2018), Founding Editor-in-Chief, Journal of Neuroimaging.

J Neuroimaging 2018 Nov;28(6):555

 American Society of Neuroimaging.

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http://doi.wiley.com/10.1111/jon.12567
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November 2018
13 Reads

Pediatric Congenital Cerebrovascular Anomalies.

J Neuroimaging 2019 Mar 31;29(2):165-181. Epub 2018 Oct 31.

Department of Interventional Radiology, Sanford Aberdeen Clinic, Aberdeen, SD.

Congenital cerebrovascular anomalies in the pediatric age group are myriad with diverse etiologies. The purpose of this paper is to provide an imaging overview of congenital vascular malformations and vascular tumors, as these conditions are varied and the characteristic vascular abnormality may even suggest the underlying systemic condition in helping to guide further management. For example, the identification of an arterial anomaly such as agenesis/hypoplasia/duplication may warrant further evaluation for an associated syndrome. Read More

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http://doi.wiley.com/10.1111/jon.12575
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March 2019
24 Reads

Diffusely Abnormal White Matter, T Burden of Disease, and Brain Volume in Relapsing-Remitting Multiple Sclerosis.

J Neuroimaging 2019 Jan 30;29(1):151-159. Epub 2018 Oct 30.

Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

Background And Purpose: Multiple sclerosis (MS) diffusely abnormal white matter (DAWM) is a mildly hyperintense magnetic resonance imaging abnormality distinct from typical lesions. Our goal was to investigate the prevalence and natural history of DAWM in a large cohort (n = 348) of relapsing-remitting MS (RRMS) patients.

Methods: The presence of DAWM and relationship to changes in T burden of disease (BOD), brain volume (brain fractional ratio, BFR), and disability (Expanded Disability Status Scale, EDSS) were investigated at baseline and year 7-8 (long-term follow-up, LTF). Read More

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http://doi.wiley.com/10.1111/jon.12574
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January 2019
5 Reads

Assessing the Relationship between Atherosclerotic Cardiovascular Disease Risk Score and Carotid Artery Imaging Findings.

J Neuroimaging 2019 Jan 25;29(1):119-125. Epub 2018 Oct 25.

Department of Radiology, Neuroradiology Section, Stanford University School of Medicine, Palo Alto, CA.

Background And Purpose: To characterize the relationship between computed tomography angiography (CTA) imaging characteristics of carotid artery and the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) score.

Methods: We retrospectively identified all patients who underwent a cervical CTA at our institution from January 2013 to July 2016, extracted clinical information, and calculated the 10-year ASCVD score using the Pooled Cohort Equations from the 2013 ACC/AHA guidelines. We compared the imaging features of artery atherosclerosis derived from the CTAs between low and high risk. Read More

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http://doi.wiley.com/10.1111/jon.12573
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January 2019
15 Reads
1.820 Impact Factor

The Role of Diffusion Tensor Imaging in Detecting Hippocampal Injury Following Neonatal Hypoxic-Ischemic Encephalopathy.

J Neuroimaging 2019 Mar 16;29(2):252-259. Epub 2018 Oct 16.

Division of Pediatric Radiology and Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD.

Background And Purpose: Neonatal hypoxic-ischemic injury of the brain and resultant encephalopathy (HIE) leads to major developmental impairments by school age. Conventional/anatomical MRI often fails to detect hippocampal injury in mild cases. We hypothesize that diffusion tensor imaging (DTI) has greater sensitivity for identifying subtle hippocampal injury. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403004PMC
March 2019
4 Reads

Neuroimaging in Psychiatric Disorders: A Bibliometric Analysis of the 100 Most Highly Cited Articles.

J Neuroimaging 2019 Jan 11;29(1):14-33. Epub 2018 Oct 11.

Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Background And Purpose: Extensive research has been conducted to find neuroimaging biomarkers for psychiatric disorders. This study aimed at identifying trends of the 100 most highly cited articles on neuroimaging in primary psychiatric disorders.

Methods: The most highly cited original research articles were identified and analyzed, following searches of MEDLINE and Web of Science All Databases. Read More

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http://doi.wiley.com/10.1111/jon.12570
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January 2019
9 Reads
1.818 Impact Factor

Functional Brain Network Changes Following Use of an Allostatic, Closed-Loop, Acoustic Stimulation Neurotechnology for Military-Related Traumatic Stress.

J Neuroimaging 2019 Jan 10;29(1):70-78. Epub 2018 Oct 10.

Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC.

Background And Purpose: Post-traumatic stress disorder is associated with connectivity changes in the default mode, central executive, and salience networks, and other brain regions. This study evaluated changes in network connectivity associated with usage of High-resolution, relational, resonance-based electroencephalic mirroring (HIRREM ; Brain State Technologies, Scottsdale, AZ), a closed-loop, allostatic, acoustic stimulation neurotechnology, for military-related traumatic stress.

Methods: Eighteen participants (17 males, mean age 41 years [SD = 7], 15 active duty) enrolled in an IRB approved pilot trial for symptoms of military-related traumatic stress. Read More

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http://doi.wiley.com/10.1111/jon.12571
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January 2019
3 Reads

Arterial Spin Labeling MRI to Measure Cerebral Blood Flow in Untreated Ischemic Stroke.

J Neuroimaging 2019 Mar 9;29(2):193-197. Epub 2018 Oct 9.

Neurology Unit, Azienda Ospedaliero-Universitaria of Parma, Parma, Italy.

Background And Purpose: This study aims to investigate the significance of regional hyperperfusion (RH) detected by arterial spin labeling (ASL) in a group of untreated stroke patients, within 24-36 hours after symptom onset. The relationship between RH volume and infarcted volume (DIV) as defined on diffusion weighted images (DWIs) was evaluated.

Methods: Of the 346 consecutive acute stroke patients who attended our center, we retrospectively reviewed MRI studies of 47 patients who were ineligible for standard treatment with intravenous tissue plasminogen activator. Read More

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http://doi.wiley.com/10.1111/jon.12569
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March 2019
2 Reads