6,937 results match your criteria Journal of Neural Transmission[Journal]


The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis.

J Neural Transm (Vienna) 2019 Feb 15. Epub 2019 Feb 15.

Department of Histology, School of Medicine in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.

Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions. The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus of the stria terminalis (BNST). The BNST is involved in the mechanism of fear learning, integration of stress and reward circuits, and pathogenesis of addiction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01984-3DOI Listing
February 2019

Validation of a prototype tau Thr231 phosphorylation CSF ELISA as a potential biomarker for Alzheimer's disease.

J Neural Transm (Vienna) 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Georg-August University, Von-Siebold-Str. 5, 37075, Goettingen, Germany.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of extracellular amyloid plaques (senile plaques) and intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein. This process leads to neuronal degradation and neuronal death. Phosphorylation of tau protein at threonine 231 (p-tau231) has been shown to be characteristic in post-mortem brain tissue of patients with AD and it can be sensitively detected in cerebrospinal fluid (CSF). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01982-5DOI Listing
February 2019

The role of neurotrophins in psychopathology and cardiovascular diseases: psychosomatic connections.

J Neural Transm (Vienna) 2019 Feb 14. Epub 2019 Feb 14.

Department of Family Medicine, Semmelweis University, Budapest, Hungary.

Cardiovascular (CV) diseases and mood disorders are common public health problems worldwide. Their connections are widely studied, and the role of neurotrophins (NTs) is already supposed in both conditions. However, data in the literature of clinical aspects are sometimes controversial and no reviews are available describing possible associations between CV risk and mood disorders based on NTs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01973-6DOI Listing
February 2019

Dementia spectrum disorders: lessons learnt from decades with PET research.

J Neural Transm (Vienna) 2019 Feb 14. Epub 2019 Feb 14.

Neurodegeneration Imaging Group, Maurice Wohl Clinical Neuroscience Institute, 125 Coldharbour Lane, Camberwell, London, SE5 9NU, UK.

The dementia spectrum encompasses a range of disorders with complex diagnosis, pathophysiology and limited treatment options. Positron emission tomography (PET) imaging provides insights into specific neurodegenerative processes underlying dementia disorders in vivo. Here we focus on some of the most common dementias: Alzheimer's disease, Parkinsonism dementias including Parkinson's disease with dementia, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal syndrome, and frontotemporal lobe degeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01975-4DOI Listing
February 2019
1 Read

Dopamine in psychiatry: a historical perspective.

J Neural Transm (Vienna) 2019 Feb 13. Epub 2019 Feb 13.

Medical Journal of Australia, Sydney, NSW, Australia.

Dopamine is the principal transmitter of several central nervous system pathways originating in the midbrain and critically involved in motor activity, learning and motivation, disruptions of which have been implicated in a number of disorders, including Parkinson disease and schizophrenia. Dopamine played a particularly significant role in the history of neurochemistry. Following a series of investigations between 1957 and 1965, commencing in the laboratory and completed in the clinic, the significance of chemical neurotransmission for normal CNS function was first demonstrated in the case of dopamine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01987-0DOI Listing
February 2019

The role of pre-, peri-, and postnatal risk factors in bipolar disorder and adult ADHD.

J Neural Transm (Vienna) 2019 Feb 13. Epub 2019 Feb 13.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt am Main, Germany.

Gene-environment-development interactions are suggested to play a crucial role in psychiatric disorders. However, it is not clear if there are specific risk gene interactions with particular pre-, peri-, and postnatal risk factors for distinct disorders, such as adult attention-deficit-/hyperactivity disorder (aADHD) and bipolar disorder (BD). In this pilot study, the first aim was to investigate retrospective self-reports of pre-, peri-, and postnatal complications and risk factors from 126 participants (aADHD, BD, and healthy controls) and their mothers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01983-4DOI Listing
February 2019
1 Read

Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence.

J Neural Transm (Vienna) 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany.

Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [F]-fallypride positron emission tomography and stressful life events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01985-2DOI Listing
February 2019

Association between physical activity and dementia's risk factors in patients with Parkinson's disease.

J Neural Transm (Vienna) 2019 Feb 12. Epub 2019 Feb 12.

Department of Systems Medicine, University of Roma "Tor Vergata", Via Montpellier 1, 00135, Rome, Italy.

Evidence suggests that physical activity (PA) exerts beneficial effects on neurodegenerative processes, either as symptomatic relief or disease-modifying strategy. Actually, it may represent a viable neuroprotective intervention in Parkinson's disease dementia (PDD), a severe, frequent, and untreatable complication of Parkinson's disease (PD). According to such hypothesis, this cross-sectional study tested, in PD patients, the association between levels of PA and well-known risk factors for PDD, such as mood disorders and amyloid-β42 CSF content. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01979-0DOI Listing
February 2019
5 Reads

Comparison of clinical and neuropathological diagnoses of neurodegenerative diseases in two centres from the Brains for Dementia Research (BDR) cohort.

J Neural Transm (Vienna) 2019 Feb 7. Epub 2019 Feb 7.

Department of Basic and Clinical Neuroscience, IoPPN, King's College London, London, UK.

Early detection and accurate diagnosis of neurodegenerative disorders may provide better epidemiological data, closer monitoring of disease progression and enable more specialised intervention. We analysed the clinical records and pathology of brain donations from 180 patients from two Brains for Dementia Research cohorts to determine the agreement between in-life clinical diagnosis and post-mortem pathological results. Clinical diagnosis was extracted from medical records and cases assigned into broad clinical groups; control, Alzheimer's disease (AD), vascular dementia (CVD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD) and combined diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-01967-wDOI Listing
February 2019
2 Reads

Correction to: Cerebral perfusion abnormalities in patients with persistent postural-perceptual dizziness (PPPD): a SPECT study.

J Neural Transm (Vienna) 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

The authors inadvertently forgot to provide the following funding information in the original publication: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (2018R1A6A3A11041118). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01977-2DOI Listing
February 2019

Subjective and physiological stress measurement in a multiple sclerosis sample and the relation with executive functions performance.

J Neural Transm (Vienna) 2019 Feb 6. Epub 2019 Feb 6.

Programa de Pós-Graduação em Psicologia, LPNeC, (Laboratório de Psicologia Experimental, Neurociência e Comportamento), Instituto de Psicologia, Universidade Federal do Rio Grande do Sul (UFRGS), Ramiro Barcelos, 2600, Sala 116, Santa Cecilia, Porto Alegre, RS, 90035-003, Brazil.

In multiple sclerosis (MS), hypothalamic-pituitary-adrenal (HPA) axis functioning may be dysregulated due to the high cortisol levels involved in the disease activity. HPA axis dysregulation can affect cognitive performance, including executive functions. This study aimed to evaluate hair cortisol concentration and perceived stress as well as verify the association with the performance of executive function in both individuals diagnosed with MS and control individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01981-6DOI Listing
February 2019
1 Read

Management of delirium in Parkinson's disease.

J Neural Transm (Vienna) 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.

Delirium is an acute and fluctuating disturbance of attention and awareness. Pre-existing cognitive disturbances or dementia are the most significant risk factors for developing delirium and precipitating factors such as drug treatment, infections, trauma, or surgery may trigger delirium. Patients with Parkinson's disease (PD) are at an increased risk for delirium which may be underdiagnosed due to phenomenological overlap between delirium and chronic neuropsychiatric features of PD or side effects of dopaminergic medication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01980-7DOI Listing
February 2019
6 Reads

Dopaminergic denervation using [I]-FPCIT and pain in Parkinson's disease: a correlation study.

J Neural Transm (Vienna) 2019 Jan 31. Epub 2019 Jan 31.

ToNIC, Toulouse Neuroimaging Center, University of Toulouse, Inserm, UPS, Toulouse, France.

In patients with Parkinson's disease (PD), abnormal activations of nociceptive brain areas and lowered pain thresholds were reported, probably reflecting a central modification of pain processing. The aim of this study was to investigate the possible correlation between the striatal and extrastriatal dopaminergic system and pain threshold in PD patients. We included 25 PD patients with various intensities of central pain (visual analog scale). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01974-5DOI Listing
January 2019

Long-term, open-label, phase 3 study of rasagiline in Japanese patients with early Parkinson's disease.

J Neural Transm (Vienna) 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Rasagiline is a monoamine oxidase B inhibitor with demonstrated efficacy and safety in patients with Parkinson's disease (PD). We recently conducted the first randomized, double-blind, placebo-controlled trial of rasagiline in Japanese patients with early PD and now report the results of its open-label extension (clinicaltrials.gov, NCT02337751). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1964-3DOI Listing
January 2019

Longterm outcome of cognition, affective state, and quality of life following subthalamic deep brain stimulation in Parkinson's disease.

J Neural Transm (Vienna) 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurology and Stereotactic Neurosurgery, Otto-von-Guericke-University, Magdeburg, Germany.

Normal cognition is an established selection criteria for subthalamic (STN) deep brain stimulation (DBS) in Parkinson's disease (PD), while concern has been raised as to aggravated cognitive decline in PD patients following STN-DBS. The present longterm study investigates cognitive status in all patients (n = 104) suffering from PD, who were treated via continuous bilateral STN-DBS between 1997 and 2006 in a single institution. Preoperative neuropsychological results were available in 79/104 of the patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01972-7DOI Listing
January 2019
4 Reads

Towards pharmacogenetic-based treatment in psychiatry.

J Neural Transm (Vienna) 2019 Jan;126(1):1-3

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-01968-9
Publisher Site
http://dx.doi.org/10.1007/s00702-018-01968-9DOI Listing
January 2019
3 Reads

Mesencephalic and extramesencephalic dopaminergic systems in Parkinson's disease.

J Neural Transm (Vienna) 2019 Jan 14. Epub 2019 Jan 14.

Department of Neurology, Philipps University Marburg, Baldingerstraße 1, 35043, Marburg, Germany.

Neurodegeneration of the nigrostriatal dopaminergic system and concurrent dopamine (DA) deficiency in the basal ganglia represent core features of Parkinson's disease (PD). Despite the central role of DA in the pathogenesis of PD, dopaminergic systems outside of the midbrain have not been systematically investigated for Lewy body pathology or neurodegeneration. Dopaminergic neurons show a surprisingly rich neurobiological diversity, suggesting that there is not one general type of dopaminergic neuron, but rather a spectrum of different dopaminergic phenotypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01970-9DOI Listing
January 2019
2 Reads

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment.

J Neural Transm (Vienna) 2019 Jan 14. Epub 2019 Jan 14.

Department of Neuroscience, Karolinska Institutet, Biomedicum, B0851, Solnavägen 9, 17177, Stockholm, Sweden.

The adenosine homo, iso and heteroreceptor complexes in the basal ganglia play a highly significant role in modulating the indirect and direct pathways and the striosomal projections to the nigro-striatal DA system. The major adenosine receptor complexes in the striato-pallidal GABA neurons can be the A2AR-D2R and A2AR-D2R-mGluR5 receptor complexes, in which A2AR protomers and mGluR5 protomers can allosterically interact to inhibit D2R protomer signaling. Through a reorganization of these heteroreceptor complexes upon chronic dopaminergic treatment a pathological and prolonged inhibition of D2R receptor protomer signaling can develop with motor inhibition and wearing off of the therapeutic effects of levodopa and dopamine receptor agonists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01969-2DOI Listing
January 2019

Long-term safety and efficacy of adjunctive rasagiline in levodopa-treated Japanese patients with Parkinson's disease.

J Neural Transm (Vienna) 2019 Jan 11. Epub 2019 Jan 11.

Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Rasagiline is a monoamine oxidase type-B inhibitor in development in Japan for Parkinson's disease (PD). This open-label study evaluated the long-term safety and efficacy of rasagiline in Japanese patients with PD receiving levodopa. Patients were aged 30-79 years and had wearing-off or weakened effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1962-5DOI Listing
January 2019

Imaging stress: an overview of stress induction methods in the MR scanner.

J Neural Transm (Vienna) 2019 Jan 10. Epub 2019 Jan 10.

Department of Psychiatry and Psychotherapy, Medical School, University of Tübingen, Calwerstrasse 14, 72076, Tübingen, Germany.

Processing of acute stress has potential implications for mental and physical health. At the same time, individuals differ largely in how strongly they react to stress. Neuroimaging paradigms have been developed to characterize the neural underpinnings of the stress response in general and to understand the mechanisms that differentiate high and low susceptible individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-01965-yDOI Listing
January 2019

Acute and chronic methylphenidate administration in intact and VTA-specific and nonspecific lesioned rats.

J Neural Transm (Vienna) 2019 Feb 8;126(2):173-182. Epub 2019 Jan 8.

Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, McGovern Medical School, 6431 Fannin Street, Houston, TX, 77030, USA.

Methylphenidate (MPD) is a psychostimulant used for the treatment of ADHD and works by increasing the bioavailability of dopamine (DA) in the brain. As a major source of DA, the ventral tegmental area (VTA) served as the principal target in this study as we aimed to understand its role in modulating the acute and chronic MPD effect. Forty-eight male Sprague-Dawley rats were divided into control, sham, electrical lesion, and 6-OHDA lesion groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1963-4DOI Listing
February 2019

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression.

J Neural Transm (Vienna) 2019 Jan 4;126(1):35-45. Epub 2019 Jan 4.

Discipline of Psychiatry, School of Medicine, University of Adelaide, North Terrace, Adelaide, SA, 5005, Australia.

Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants for the treatment of major depressive disorder (MDD). However, treatment response during an initial therapeutic trial is often poor and is difficult to predict. Heterogeneity of response to SSRIs in depressed patients is partly driven by co-occurring somatic disorders such as coronary artery disease (CAD) and obesity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-01966-xDOI Listing
January 2019
3 Reads
2.402 Impact Factor

Botulinum neurotoxin a therapy efficacy and safety for oromandibular dystonia: a meta-analysis.

J Neural Transm (Vienna) 2019 Feb 2;126(2):141-148. Epub 2019 Jan 2.

Movement Disorders Section, Department of Neurology, Hannover Medical School, Hannover, Germany.

Oromandibular dystonia (OMD) is a focal dystonia involving the mouth, jaw, and tongue. Botulinum neurotoxin (BoNT) therapy might be one form of treatment in OMD. Systematic pooling of BoNT studies in OMD remains wanting, as the derived data could provide useful information in regard to efficacy and safety issues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1960-7DOI Listing
February 2019
2 Reads

Dopamine and addiction: what have we learned from 40 years of research.

J Neural Transm (Vienna) 2018 Dec 19. Epub 2018 Dec 19.

Université de Poitiers, INSERM, U-1084, Laboratoire de Neurosciences Expérimentales et Cliniques, Poitiers, France.

Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known. The critical role of DA in addiction is supported by converging evidence that has been accumulated in the last 40 years. In the present review, first we describe the dopaminergic system in terms of connectivity, functioning and involvement in reward processes. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1957-2
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1957-2DOI Listing
December 2018
8 Reads

Oxytocin reactivity to an emotional challenge paradigm and its relation to social-cognitive functions in healthy volunteers.

J Neural Transm (Vienna) 2019 Feb 11;126(2):211-218. Epub 2018 Dec 11.

Department of Psychiatry Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinenstr 1-3, 44791, Bochum, Germany.

The neuropeptide oxytocin (OT) is known to be an important modulator of social cognition. It has been shown that lower OT plasma concentrations are linked to impairments in social cognition. Studies have also shown that intranasal OT may enhance social-cognitive abilities in healthy subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1955-4DOI Listing
February 2019
1 Read

Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.

J Neural Transm (Vienna) 2019 Feb 8;126(2):115-122. Epub 2018 Dec 8.

Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.

Increasing evidence indicates that some antiarrhythmic drugs play a pivotal role in seizures, not only in vivo studies on animals, but also in clinical trials. Some of these antiarrhythmic drugs potentiate or alleviate the anticonvulsant action of the classical antiepileptic drugs. The aim of this study was to determine the influence of dronedarone (DRO-a multichannel blocker belonging to the class III of antiarrhythmic drugs) on the anticonvulsant effects of four standard antiepileptic drugs (carbamazepine, phenobarbital, phenytoin and valproate) in the tonic-clonic seizure model in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1940-yDOI Listing
February 2019
1 Read

Complexity of electrocortical activity as potential biomarker in untreated Parkinson's disease.

J Neural Transm (Vienna) 2019 Feb 3;126(2):167-172. Epub 2018 Dec 3.

Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università degli Studi di Catania, Via Santa Sofia 78, 95123, Catania, Italy.

In Parkinson's disease (PD), the identification of instrumental biomarkers is crucial to evaluate disease susceptibility and motor stage. We evaluated self-similarity of electrocortical activity as expression of brain signal complexity in untreated PD, to investigate its possible role as a neurophysiological biomarker. We analyzed the data of 34 untreated PD subjects and 18 group-matched controls who underwent standardized electroencephalography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1961-6DOI Listing
February 2019
2 Reads

Headache in the course of multiple sclerosis: a prospective study.

J Neural Transm (Vienna) 2019 Feb 30;126(2):131-139. Epub 2018 Nov 30.

Neuroimmunological Section, Department of Neurology, University of Rostock, Rostock, Germany.

Multiple sclerosis (MS) is the most common immune-mediated inflammatory disease of the central nervous system (CNS). Early diagnosis and treatment is important to prevent progression of disability in the course of the chronic disease. Therefore, correct and fast identification of early symptoms is vital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1959-0DOI Listing
February 2019
2 Reads

Feasibility of NIRS-based neurofeedback training in social anxiety disorder: behavioral and neural correlates.

J Neural Transm (Vienna) 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstr.14, 72076, Tübingen, Germany.

Attention biases towards threat signals have been linked to the etiology and symptomatology of social anxiety disorder (SAD). Dysfunction of the dorsolateral prefrontal cortex (dlPFC) may contribute to attention biases in anxious individuals. The aim of this study was to investigate the feasibility of near-infrared spectroscopy (NIRS) neurofeedback (NF) training-targeting the dlPFC-and its effects on threat-related attention biases of individuals with SAD. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1954-5
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1954-5DOI Listing
November 2018
7 Reads

Disease duration in E200K familial Creutzfeldt-Jakob disease is correlated with clinical, radiological, and laboratory variables.

J Neural Transm (Vienna) 2018 Nov 29. Epub 2018 Nov 29.

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Previous studies have suggested that disease duration in Creutzfeldt-Jakob disease (CJD) may be related to the radiological findings or cerebrospinal fluid (CSF) tau levels; however, it is not yet established whether clinical, radiological, and laboratory findings at diagnosis can predict survival or have a prognostic value. The aim of this study was to examine whether the disease duration is correlated with clinical, radiological, and laboratory variables. The study population consisted of consecutive familial CJD (fCJD) patients that were assessed within 1 week from the diagnosis including the CJD neurological scale (CJD-NS), Minimental Status Examination, Frontal Assessment Battery, NIH Stroke Scale, and the expanded disability status scale. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1958-1
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1958-1DOI Listing
November 2018
13 Reads

Correction to: Tyrosine-hydroxylase immunoreactivity in the mouse transparent brain and adrenal glands.

J Neural Transm (Vienna) 2018 Nov 17. Epub 2018 Nov 17.

Institut de la Vision, Sorbonne Université, INSERM CNRS UMRS 968, Paris, France.

Unfortunately, the given name and family name of the fourth author was incorrectly tagged in the xml data, therefore it is abbreviated wrongly as ''Goazigo AR'' in Pubmed. The correct given name is Annabelle and family name is Reaux‑Le Goazigo. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1956-3
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1956-3DOI Listing
November 2018
10 Reads

Genetic variations in the ADCK1 gene predict paliperidone palmitate efficacy in Han Chinese patients with schizophrenia.

J Neural Transm (Vienna) 2019 Jan 13;126(1):19-25. Epub 2018 Nov 13.

Peking University Sixth Hospital and Peking University Institute of Mental Health and Key Laboratory of Mental Health, Ministry of Health (Peking University) and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China.

Genome-wide association study results have linked ADCK1 genetic variation with paliperidone efficacy in a European cohort. However, the generalizability of this locus to non-European populations is unknown. Han Chinese schizophrenia patients (n = 159) were treated with paliperidone palmitate and symptom severity was assessed over 3 months. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1953-6
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1953-6DOI Listing
January 2019
13 Reads
2.402 Impact Factor

The role of exposure to pesticides in the etiology of Parkinson's disease: a F-DOPA positron emission tomography study.

J Neural Transm (Vienna) 2019 Feb 13;126(2):159-166. Epub 2018 Nov 13.

Department of Nuclear Medicine, Yitzhak Shamir Medical Center, 70300, Zerifin, Israel.

Susceptibility to Parkinson's disease (PD) is believed to involve an interaction between genetic and environmental factors. The role of pesticides as a risk factor of PD and neurodegeneration remains controversial. An asymmetric decrease in ligand uptake on F-DOPA positron emission tomography (PET), especially in the dorsal putamen, is a sensitive marker of PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1951-8DOI Listing
February 2019
12 Reads

Inhibitors of MAO-B and COMT: their effects on brain dopamine levels and uses in Parkinson's disease.

Authors:
John P M Finberg

J Neural Transm (Vienna) 2018 Nov 1. Epub 2018 Nov 1.

Neuroscience Group, Rappaport Faculty of Medicine, Haifa, Israel.

MAO-B and COMT are both enzymes involved in dopamine breakdown and metabolism. Inhibitors of these enzymes are used in the treatment of Parkinson's disease. This review article describes the scientific background to the localization and function of the enzymes, the physiological changes resulting from their inhibition, and the basic and clinical pharmacology of the various inhibitors and their role in treatment of Parkinson's disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1952-7DOI Listing
November 2018
1 Read

Clinical implications of APOE genotyping for late-onset Alzheimer's disease (LOAD) risk estimation: a review of the literature.

J Neural Transm (Vienna) 2019 Jan 31;126(1):65-85. Epub 2018 Oct 31.

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

Alzheimer's disease is a genetically complex neurodegenerative disorder representing the leading cause of dementia. Advances in personal genomics are increasing the public uptake of genetic susceptibility testing for complex diseases such as late-onset Alzheimer's disease (LOAD). For LOAD, the discovery of the major risk ε4 allele of the APOE gene has prompted a debate on the ethics and utility of presymptomatic (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1934-9DOI Listing
January 2019
4 Reads
2.402 Impact Factor

Cerebral perfusion abnormalities in patients with persistent postural-perceptual dizziness (PPPD): a SPECT study.

J Neural Transm (Vienna) 2019 Feb 31;126(2):123-129. Epub 2018 Oct 31.

Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Persistent postural-perceptual dizziness (PPPD) is a recently defined syndrome with chronic dizziness interrupting daily life. Although the high levels of anxiety and functional changes in postural control strategy and multi-sensory information processing and integration may be underlying the pathophysiology, its neural mechanisms are poorly understood. The aim of this study was to examine the regional cerebral blood flow (rCBF) in patients with PPPD using single photon emission computed tomography (SPECT). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1948-3
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1948-3DOI Listing
February 2019
5 Reads

Hair cortisol concentration in mothers and their children: roles of maternal sensitivity and child symptoms of attention-deficit/hyperactivity disorder.

J Neural Transm (Vienna) 2018 Oct 29. Epub 2018 Oct 29.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Hans Sachs Str. 6, 35039, Marburg, Germany.

Associations between mothers' and children's cortisol secretion parameters are well established. According to the bio-behavioral synchrony model, these associations reflect influences of the mother-child relationship, the child's social adjustment, and might also reflect shared genetic dispositions. From the bio-behavioral synchrony model, we predicted a stronger mother-child hair cortisol concentration (HCC) link in mothers showing highly adequate (compared to those showing less adequate) parenting behaviors and in children showing low (compared to those showing high) ADHD symptoms. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1944-7
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1944-7DOI Listing
October 2018
9 Reads

The associations between serum vascular endothelial growth factor, tumor necrosis factor and interleukin 4 with the markers of blood-brain barrier breakdown in patients with paraneoplastic neurological syndromes.

J Neural Transm (Vienna) 2019 Feb 29;126(2):149-158. Epub 2018 Oct 29.

Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland.

The blood-brain barrier (BBB) disruption is a critical step in paraneoplastic neurological syndrome (PNS) development. Several cytokines have been implicated in BBB breakdown. However, the exact step-by-step mechanism in which PNS develops is unknown, and the relationship between a systemic neoplasm and BBB is multilevel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1950-9DOI Listing
February 2019
3 Reads

Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson's disease: a systematic review.

J Neural Transm (Vienna) 2018 Oct 29. Epub 2018 Oct 29.

Medical Science Post Graduation Program, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2400, Porto Alegre, RS, Brazil.

Parkinson's disease (PD) is a progressive and multifactorial neurodegenerative disease. It has been suggested that a dysregulation of the hypothalamic-pituitary-adrenal axis (HPA) occurs in PD. Furthermore, this dysregulation may be involved in triggering, exacerbation or progression of disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1947-4DOI Listing
October 2018
1 Read

On the practical aspects of characterising monoamine oxidase inhibition in vitro.

Authors:
Andrew Holt

J Neural Transm (Vienna) 2018 Nov 29;125(11):1685-1705. Epub 2018 Oct 29.

Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.44 Walter Mackenzie Centre, Edmonton, AB, T6G 2B7, Canada.

The development of novel inhibitors of human monoamine oxidase enzymes with improved pharmacodynamic and pharmacokinetic profiles has, in the past, been hampered by limited access to enzyme, by assay protocols offering limited throughput, and by inappropriate analyses of kinetic data. More recently, high-level expression of human enzymes in yeast has facilitated thorough examinations of steady-state enzyme behaviour that have led to improvements in our understanding of the mathematical underpinnings of kinetic analyses of monoamine oxidases. However, with these improvements have come a realisation that to be useful, more data points across wider concentration ranges are required. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1943-8
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1943-8DOI Listing
November 2018
7 Reads

Neurogenesis within the hippocampus after chronic methylphenidate exposure.

J Neural Transm (Vienna) 2019 Feb 28;126(2):201-209. Epub 2018 Oct 28.

Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, 37614, USA.

Methylphenidate is a psychostimulant used to treat attention deficit hyperactivity disorder. Neurogenesis occurs throughout adulthood within the dentate gyrus of the hippocampus and can be altered by psychoactive medications; however, the impact of methylphenidate on neurogenesis is not fully understood. We investigated the effects of chronic low (1 mg/kg) and high (10 mg/kg) intraperitoneal doses of methylphenidate on neurogenesis in mouse hippocampus following 28 days and 56 days of treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1949-2DOI Listing
February 2019
12 Reads

Effects of DRD2 splicing-regulatory polymorphism and DRD4 48 bp VNTR on crack cocaine addiction.

J Neural Transm (Vienna) 2019 Feb 26;126(2):193-199. Epub 2018 Oct 26.

Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

There is evidence that dopamine receptors D2 (DRD2) and D4 (DRD4) polymorphisms may influence substance use disorders (SUD) susceptibility both individually and through their influence in the formation of DRD2-DRD4 heteromers. The dopaminergic role on the vulnerability to addiction appears to be influenced by sex. A cross-sectional study with 307 crack cocaine addicts and 770 controls was conducted. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1946-5
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1946-5DOI Listing
February 2019
3 Reads

Emotional facedness in Parkinson's disease.

J Neural Transm (Vienna) 2018 Dec 20;125(12):1819-1827. Epub 2018 Oct 20.

Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

People with Parkinson's disease (PD) have a deficit of facial expression. Previous studies indicate that hemispheric dominance for emotional processing can give rise to an asymmetric pattern of facial expression of emotion. In this study, we aimed to evaluate possible asymmetry in facial emotion expressivity in PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1945-6DOI Listing
December 2018
27 Reads

Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases.

J Neural Transm (Vienna) 2018 Nov 19;125(11):1719-1733. Epub 2018 Oct 19.

Technion-Bruce Rappaport Faculty of Medicine, Rappaport Family Research Institute, Haifa, Israel.

In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933 Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and dopamine. Zeller gave it the name monoamine oxidase (MAO) to distinguish it from the enzyme that oxidatively deaminated diamines. MAO was recognized as an enzyme of crucial interest to pharmacologists because it catalyzed the major inactivation pathway for the catecholamines (and, later, 5-hydroxytryptamine, as well). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1942-9DOI Listing
November 2018
1 Read

Transcranial direct current stimulation (tDCS) over right temporoparietal junction (rTPJ) for social cognition and social skills in adults with autism spectrum disorder (ASD).

J Neural Transm (Vienna) 2018 Dec 19;125(12):1857-1866. Epub 2018 Oct 19.

Department of Psychology, University of New Mexico, MSC03 2220 1 University of New Mexico, Albuquerque, NM, 87131, USA.

Social deficits are core to autism spectrum disorder (ASD). Current treatments are extremely time- and labor-intensive. Transcranial direct current stimulation (tDCS) may be a promising treatment modality to safely enhance treatments targeting social cognition and social skills. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1938-5
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1938-5DOI Listing
December 2018
5 Reads

Repetitive transcranial magnetic stimulation for treatment of tardive syndromes: double randomized clinical trial.

J Neural Transm (Vienna) 2019 Feb 13;126(2):183-191. Epub 2018 Oct 13.

Sobell Department of Motor Neuroscience and Movement Disorders, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Tardive syndromes (TDS) typically manifest 3 months or later after exposure to antipsychotic drugs, and unfortunately have no satisfactory medical treatment. We explored the possibility of using therapeutic repetitive transcranial magnetic stimulation (rTMS). Twenty-six patients were allocated to receive real or sham rTMS over the hand/arm area of motor cortex (M1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1941-xDOI Listing
February 2019
17 Reads

Is the dual-task cost of walking and texting unique in people with multiple sclerosis?

J Neural Transm (Vienna) 2018 Dec 8;125(12):1829-1835. Epub 2018 Oct 8.

Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

The objective of the study was to investigate cognitive-motor interference of walking while texting in people with multiple sclerosis (PwMS). The study included 30 PwMS, mean disease duration 11.8 (SD = 6. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1939-4
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1939-4DOI Listing
December 2018
2 Reads
2.402 Impact Factor

The frequency and diagnostic accuracy of hand deformities in Parkinson's disease.

J Neural Transm (Vienna) 2018 Dec 5;125(12):1813-1817. Epub 2018 Oct 5.

New York Medical College, Valhalla, NY, USA.

Hand deformities are well-known abnormalities observed in patients with Parkinson's disease (PD). We determined the frequency and diagnostic accuracy of hand deformities in PD. We studied 44 consecutive patients with PD, 44 age- and gender-matched normal controls and 22 patients with essential tremor (ET). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1937-6DOI Listing
December 2018
2 Reads

Correlation between MCP-1-2518A/G polymorphism and the risk of Alzheimer's disease.

J Neural Transm (Vienna) 2018 Dec 3;125(12):1781-1786. Epub 2018 Oct 3.

Department of Biopharmaceutical, Yulin Normal University, Yulin, 537000, China.

The -2518A/G polymorphism in monocyte chemotactic protein-1 (MCP-1) has been extensively investigated for association with Alzheimer's disease (AD); however, the results from different studies are inconsistent. The aim of this study was to draw an accurate conclusion of the association. All eligible case-control studies were searched in PubMed, Embase, Chinese National Knowledge Infrastructure, China Biological Medicine Databases, and Wanfang Databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-018-1936-7DOI Listing
December 2018
3 Reads

Effect of serum uric acid on cognition in patients with idiopathic REM sleep behavior disorder.

J Neural Transm (Vienna) 2018 Dec 3;125(12):1805-1812. Epub 2018 Oct 3.

Department of Neurology, China-Japan Friendship Hospital, Beijing, China.

Idiopathic rapid eye movement sleep behavior disorder (iRBD) likely represents the prodromal stage of synucleinopathy. The present study investigated how levels of serum uric acid (UA) affect cognition and motor function in patients with iRBD. A total of 42 patients with iRBD and 45 healthy controls were included. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00702-018-1935-8
Publisher Site
http://dx.doi.org/10.1007/s00702-018-1935-8DOI Listing
December 2018
9 Reads
2.402 Impact Factor