6,956 results match your criteria Journal of Neural Transmission[Journal]


Clinical correlates of abnormal subcortical volumes in Essential Tremor.

J Neural Transm (Vienna) 2019 Apr 20. Epub 2019 Apr 20.

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka, 560029, India.

Essential tremor (ET) is considered to be a neurodegenerative disorder and it is plausible that the observed motor and non-motor symptoms may be attributable to functional alterations secondary to abnormalities of subcortical nuclei. This study aims to compare the volumes of subcortical nuclei in patients with ET to ascertain neuroimaging correlates of motor and non-motor features of ET. Forty patients of ET and 40 age- and gender-matched healthy controls (HC) were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s00702-019-02004-0DOI Listing

Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells.

J Neural Transm (Vienna) 2019 Apr 19. Epub 2019 Apr 19.

Department of Biology and Pharmacy, Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, Yulin Normal University, Jiaoyudong Road No. 1303, Yuzhou District, Yulin, 537000, Guangxi Zhuang Autonomous Region, China.

Microglia activation-mediated neuroinflammation plays an important role in the progression of Parkinson's disease (PD). However, effects of microglia activation on dopaminergic neuronal cell (DAC) fate are still poorly understood. The objective of this study was to explore the neurotoxic effects of microglia activation-mediated oxidative injury in DACs and its possible mechanisms. Read More

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http://link.springer.com/10.1007/s00702-019-02005-z
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http://dx.doi.org/10.1007/s00702-019-02005-zDOI Listing
April 2019
3 Reads

Hypersalivation: update of the German S2k guideline (AWMF) in short form.

J Neural Transm (Vienna) 2019 Apr 10. Epub 2019 Apr 10.

Department for Otorhinolaryngology, University of Luebeck, Ratzeburger Allee 120, 23538, Lübeck, Germany.

Hypersalivation describes a relatively excessive salivary flow, which wets the patient himself and his surroundings. It may result because of insufficient oro-motor function, dysphagia, decreased central control and coordination. This update presents recent changes and innovation in the treatment of hypersalivation. Read More

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http://dx.doi.org/10.1007/s00702-019-02000-4DOI Listing
April 2019
1 Read

Mild cognitive impairment in Parkinson's disease.

J Neural Transm (Vienna) 2019 Apr 8. Epub 2019 Apr 8.

Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Understanding on the clinical features and neural mechanisms leading to cognitive impairment and dementia in Parkinson's disease (PD) has notably increased. At time of diagnosis, nearly all PD patients present some degree of cognitive impairment not enough severe as to significantly affect functional independence. However, even mild cognitive changes have a measurable impact to functional capacity in PD. Read More

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http://dx.doi.org/10.1007/s00702-019-02003-1DOI Listing
April 2019
1 Read

Time for a new definition of Parkinson's disease.

J Neural Transm (Vienna) 2019 Apr 5. Epub 2019 Apr 5.

Department of Neurology, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.

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http://dx.doi.org/10.1007/s00702-019-01999-wDOI Listing

Biomarkers of Parkinson's disease: 20 years later.

J Neural Transm (Vienna) 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany.

Despite intensive effort, biomarker research for the detection of prodromal stage, diagnosis and progression of Parkinson's disease (PD) falls short of expectations. This article reviews the attempts in the last 20 years to find a biomarker, addresses challenges along the biomarker search and suggests the steps that should be taken to overcome these challenges. Although several biomarkers are currently available, none of them is specific enough for diagnosis, prediction of future PD or disease progression. Read More

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http://dx.doi.org/10.1007/s00702-019-02001-3DOI Listing

Dopaminergic modulation of striatal function and Parkinson's disease.

J Neural Transm (Vienna) 2019 Apr 1;126(4):411-422. Epub 2019 Apr 1.

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

The striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a diverse array of cellular and synaptic functions that control goal-directed actions and habits. The loss of this innervation has long been thought to be the principal cause of the cardinal motor symptoms of Parkinson's disease (PD). Moreover, chronic, pharmacological overstimulation of striatal dopamine (DA) receptors is generally viewed as the trigger for levodopa-induced dyskinesia (LID) in late-stage PD patients. Read More

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http://dx.doi.org/10.1007/s00702-019-01997-yDOI Listing
April 2019
2 Reads

Association study and a systematic meta-analysis of the VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder.

J Neural Transm (Vienna) 2019 Apr 28;126(4):517-529. Epub 2019 Mar 28.

Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.

Attention-deficit hyperactivity disorder (ADHD) has been postulated to associate with dopaminergic dysfunction, including the dopamine transporter (DAT1). Several meta-analyses showed small but significant association between the 10-repeat allele in the DAT1 gene in 3'-untranslated region variant number tandem repeat polymorphism and child and adolescent ADHD, whereas in adult ADHD the 9-repeat allele was suggested to confer as risk allele. Interestingly, recent evidence indicated that the long-allele variants (10 repeats and longer) might confer to lower expression of the transporter in comparison to the short-allele. Read More

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http://dx.doi.org/10.1007/s00702-019-01998-xDOI Listing
April 2019
1 Read

Olfaction and taste in Parkinson's disease: the association with mild cognitive impairment and the single cognitive domain dysfunction.

J Neural Transm (Vienna) 2019 Mar 25. Epub 2019 Mar 25.

Section of Neurology, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Piazzale Scuro 10, 37134, Verona, Italy.

Mild cognitive impairment (MCI) and chemosensory dysfunction are non-motor symptoms of Parkinson's disease (PD), but their association is unclear. We explored if MCI and the involvement of single cognitive domains influence olfaction and taste in PD. The role of demographic, clinical and neuropsychiatric variables was tested. Read More

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http://dx.doi.org/10.1007/s00702-019-01996-zDOI Listing
March 2019
1 Read

The attentional cost of movement in multiple sclerosis.

J Neural Transm (Vienna) 2019 Mar 25. Epub 2019 Mar 25.

Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Individuals living with multiple sclerosis frequently have impairments in mobility. These impairments are more pronounced when they engage in a cognitively demanding mobility tasks (i.e. Read More

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http://dx.doi.org/10.1007/s00702-019-01990-5DOI Listing
March 2019
1 Read

On Nobel Laureate Arvid Carlsson.

Authors:
Kjell Fuxe

J Neural Transm (Vienna) 2019 Apr;126(4):357

Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00702-019-01994-1DOI Listing

Actigraphy studies and clinical and biobehavioural correlates in schizophrenia: a systematic review.

J Neural Transm (Vienna) 2019 Mar 19. Epub 2019 Mar 19.

Research Division, Institute of Mental Health, 10 Buangkok View, Singapore, 539747, Singapore.

Actigraphy is a non-invasive method of monitoring circadian rhythms and motor activity. We systematically reviewed extant evidence until September 2018 pertaining to actigraphy use in schizophrenia, its clinical/biological correlates and posit future research directions. Within 38 included studies involving 2700 subjects, patients with schizophrenia generally have lower motor activity levels, poorer sleep quality and efficiency, increased sleep fragmentation and duration compared with healthy controls. Read More

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http://dx.doi.org/10.1007/s00702-019-01993-2DOI Listing
March 2019
1 Read

Abnormal hippocampal subfields are associated with cognitive impairment in Essential Tremor.

J Neural Transm (Vienna) 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560029, India.

Multi-domain cognitive impairment (CI) has been frequently described in patients with essential tremor (ET). However, the exact neuroanatomical basis for this impairment is uncertain. This study aims to ascertain the role of the hippocampal formation in cognitive impairment in ET. Read More

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http://link.springer.com/10.1007/s00702-019-01992-3
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http://dx.doi.org/10.1007/s00702-019-01992-3DOI Listing
March 2019
3 Reads

Hand, foot, and spine deformities in parkinsonian disorders.

J Neural Transm (Vienna) 2019 Mar 27;126(3):253-264. Epub 2019 Feb 27.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 7200 Cambridge St, Suite #9A, Houston, TX, 77030, USA.

Hand and foot deformities, known as "striatal deformities", and other musculoskeletal abnormalities such as dropped head, bent spine, camptocormia, scoliosis and Pisa syndrome, are poorly understood and often misdiagnosed features of Parkinson's disease and other parkinsonian syndromes. These deformities share some similarities with known rheumatologic conditions and can be wrongly diagnosed as rheumatoid arthritis, osteoarthritis, psoriatic arthritis, Dupuytren's contracture, trigger finger, or other rheumatologic or orthopedic conditions. Neurologists, rheumatologists, and other physicians must be familiar with these deformities to prevent misdiagnosis and unnecessary diagnostic tests, and to recommend appropriate treatment options. Read More

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http://dx.doi.org/10.1007/s00702-019-01986-1DOI Listing
March 2019
3 Reads

Classical dopamine agonists.

J Neural Transm (Vienna) 2019 Apr 25;126(4):449-454. Epub 2019 Feb 25.

Pfizer Pharma GmbH, Linkstraße 10, 10785, Berlin, Germany.

The pioneering work of Arvid Carlsson has laid the foundation for a number of innovative therapies for severe central nervous system (CNS) diseases. He was awarded the Nobel Price for the discovery of the crucial role of dopamine (DA) as a neurotransmitter in the CNS, thereby forming the basis for the symptomatic therapy of Parkinson's disease (PD) with L-DOPA and subsequently dopaminergic drugs. Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated. Read More

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http://dx.doi.org/10.1007/s00702-019-01989-yDOI Listing
April 2019
2 Reads

Stress and Alzheimer's disease.

J Neural Transm (Vienna) 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, University Cologne, Cologne, Germany.

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Due to demographic change in higher income countries and rising life expectancy in middle- and low-income countries, the prevalence of AD will increase significantly in the coming years. In the search for effective AD prevention, the role of stress in the development of AD has come into focus. Read More

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http://dx.doi.org/10.1007/s00702-019-01988-zDOI Listing
February 2019
5 Reads

The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis.

J Neural Transm (Vienna) 2019 Mar 15;126(3):349-355. Epub 2019 Feb 15.

Department of Histology, School of Medicine in Katowice, Medical University of Silesia, ul. Medyków 18, 40-752, Katowice, Poland.

Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions. The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus of the stria terminalis (BNST). The BNST is involved in the mechanism of fear learning, integration of stress and reward circuits, and pathogenesis of addiction. Read More

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http://dx.doi.org/10.1007/s00702-019-01984-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449486PMC
March 2019
1 Read

Validation of a prototype tau Thr231 phosphorylation CSF ELISA as a potential biomarker for Alzheimer's disease.

J Neural Transm (Vienna) 2019 Mar 14;126(3):339-348. Epub 2019 Feb 14.

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Georg-August University, Von-Siebold-Str. 5, 37075, Goettingen, Germany.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of extracellular amyloid plaques (senile plaques) and intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein. This process leads to neuronal degradation and neuronal death. Phosphorylation of tau protein at threonine 231 (p-tau231) has been shown to be characteristic in post-mortem brain tissue of patients with AD and it can be sensitively detected in cerebrospinal fluid (CSF). Read More

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http://dx.doi.org/10.1007/s00702-019-01982-5DOI Listing

The role of neurotrophins in psychopathology and cardiovascular diseases: psychosomatic connections.

J Neural Transm (Vienna) 2019 Mar 14;126(3):265-278. Epub 2019 Feb 14.

Department of Family Medicine, Semmelweis University, Budapest, Hungary.

Cardiovascular (CV) diseases and mood disorders are common public health problems worldwide. Their connections are widely studied, and the role of neurotrophins (NTs) is already supposed in both conditions. However, data in the literature of clinical aspects are sometimes controversial and no reviews are available describing possible associations between CV risk and mood disorders based on NTs. Read More

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http://dx.doi.org/10.1007/s00702-019-01973-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449302PMC
March 2019
3 Reads

Dementia spectrum disorders: lessons learnt from decades with PET research.

J Neural Transm (Vienna) 2019 Mar 14;126(3):233-251. Epub 2019 Feb 14.

Neurodegeneration Imaging Group, Maurice Wohl Clinical Neuroscience Institute, 125 Coldharbour Lane, Camberwell, London, SE5 9NU, UK.

The dementia spectrum encompasses a range of disorders with complex diagnosis, pathophysiology and limited treatment options. Positron emission tomography (PET) imaging provides insights into specific neurodegenerative processes underlying dementia disorders in vivo. Here we focus on some of the most common dementias: Alzheimer's disease, Parkinsonism dementias including Parkinson's disease with dementia, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal syndrome, and frontotemporal lobe degeneration. Read More

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http://dx.doi.org/10.1007/s00702-019-01975-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449308PMC
March 2019
4 Reads

Dopamine in psychiatry: a historical perspective.

J Neural Transm (Vienna) 2019 Apr 13;126(4):473-479. Epub 2019 Feb 13.

Medical Journal of Australia, Sydney, NSW, Australia.

Dopamine is the principal transmitter of several central nervous system pathways originating in the midbrain and critically involved in motor activity, learning and motivation, disruptions of which have been implicated in a number of disorders, including Parkinson disease and schizophrenia. Dopamine played a particularly significant role in the history of neurochemistry. Following a series of investigations between 1957 and 1965, commencing in the laboratory and completed in the clinic, the significance of chemical neurotransmission for normal CNS function was first demonstrated in the case of dopamine. Read More

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http://dx.doi.org/10.1007/s00702-019-01987-0DOI Listing

The role of pre-, peri-, and postnatal risk factors in bipolar disorder and adult ADHD.

J Neural Transm (Vienna) 2019 Feb 13. Epub 2019 Feb 13.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt am Main, Germany.

Gene-environment-development interactions are suggested to play a crucial role in psychiatric disorders. However, it is not clear if there are specific risk gene interactions with particular pre-, peri-, and postnatal risk factors for distinct disorders, such as adult attention-deficit-/hyperactivity disorder (aADHD) and bipolar disorder (BD). In this pilot study, the first aim was to investigate retrospective self-reports of pre-, peri-, and postnatal complications and risk factors from 126 participants (aADHD, BD, and healthy controls) and their mothers. Read More

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http://dx.doi.org/10.1007/s00702-019-01983-4DOI Listing
February 2019
2 Reads

Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence.

J Neural Transm (Vienna) 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychiatry and Psychotherapy, Charité Campus Mitte (CCM), Charité- Universitätsmedizin Berlin, Berlin, Germany.

Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [F]-fallypride positron emission tomography and stressful life events. Read More

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http://dx.doi.org/10.1007/s00702-019-01985-2DOI Listing
February 2019

Association between physical activity and dementia's risk factors in patients with Parkinson's disease.

J Neural Transm (Vienna) 2019 Mar 12;126(3):319-325. Epub 2019 Feb 12.

Department of Systems Medicine, University of Roma "Tor Vergata", Via Montpellier 1, 00135, Rome, Italy.

Evidence suggests that physical activity (PA) exerts beneficial effects on neurodegenerative processes, either as symptomatic relief or disease-modifying strategy. Actually, it may represent a viable neuroprotective intervention in Parkinson's disease dementia (PDD), a severe, frequent, and untreatable complication of Parkinson's disease (PD). According to such hypothesis, this cross-sectional study tested, in PD patients, the association between levels of PA and well-known risk factors for PDD, such as mood disorders and amyloid-β42 CSF content. Read More

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http://dx.doi.org/10.1007/s00702-019-01979-0DOI Listing
March 2019
9 Reads

Comparison of clinical and neuropathological diagnoses of neurodegenerative diseases in two centres from the Brains for Dementia Research (BDR) cohort.

J Neural Transm (Vienna) 2019 Mar 7;126(3):327-337. Epub 2019 Feb 7.

Department of Basic and Clinical Neuroscience, IoPPN, King's College London, London, UK.

Early detection and accurate diagnosis of neurodegenerative disorders may provide better epidemiological data, closer monitoring of disease progression and enable more specialised intervention. We analysed the clinical records and pathology of brain donations from 180 patients from two Brains for Dementia Research cohorts to determine the agreement between in-life clinical diagnosis and post-mortem pathological results. Clinical diagnosis was extracted from medical records and cases assigned into broad clinical groups; control, Alzheimer's disease (AD), vascular dementia (CVD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD) and combined diseases. Read More

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http://dx.doi.org/10.1007/s00702-018-01967-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449484PMC
March 2019
2 Reads

Correction to: Cerebral perfusion abnormalities in patients with persistent postural-perceptual dizziness (PPPD): a SPECT study.

J Neural Transm (Vienna) 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

The authors inadvertently forgot to provide the following funding information in the original publication: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (2018R1A6A3A11041118). Read More

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http://dx.doi.org/10.1007/s00702-019-01977-2DOI Listing
February 2019

Subjective and physiological stress measurement in a multiple sclerosis sample and the relation with executive functions performance.

J Neural Transm (Vienna) 2019 Feb 6. Epub 2019 Feb 6.

Programa de Pós-Graduação em Psicologia, LPNeC, (Laboratório de Psicologia Experimental, Neurociência e Comportamento), Instituto de Psicologia, Universidade Federal do Rio Grande do Sul (UFRGS), Ramiro Barcelos, 2600, Sala 116, Santa Cecilia, Porto Alegre, RS, 90035-003, Brazil.

In multiple sclerosis (MS), hypothalamic-pituitary-adrenal (HPA) axis functioning may be dysregulated due to the high cortisol levels involved in the disease activity. HPA axis dysregulation can affect cognitive performance, including executive functions. This study aimed to evaluate hair cortisol concentration and perceived stress as well as verify the association with the performance of executive function in both individuals diagnosed with MS and control individuals. Read More

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http://dx.doi.org/10.1007/s00702-019-01981-6DOI Listing
February 2019
1 Read

Management of delirium in Parkinson's disease.

J Neural Transm (Vienna) 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.

Delirium is an acute and fluctuating disturbance of attention and awareness. Pre-existing cognitive disturbances or dementia are the most significant risk factors for developing delirium and precipitating factors such as drug treatment, infections, trauma, or surgery may trigger delirium. Patients with Parkinson's disease (PD) are at an increased risk for delirium which may be underdiagnosed due to phenomenological overlap between delirium and chronic neuropsychiatric features of PD or side effects of dopaminergic medication. Read More

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http://dx.doi.org/10.1007/s00702-019-01980-7DOI Listing
February 2019
22 Reads

Dopaminergic denervation using [I]-FPCIT and pain in Parkinson's disease: a correlation study.

J Neural Transm (Vienna) 2019 Mar 31;126(3):279-287. Epub 2019 Jan 31.

ToNIC, Toulouse Neuroimaging Center, University of Toulouse, Inserm, UPS, Toulouse, France.

In patients with Parkinson's disease (PD), abnormal activations of nociceptive brain areas and lowered pain thresholds were reported, probably reflecting a central modification of pain processing. The aim of this study was to investigate the possible correlation between the striatal and extrastriatal dopaminergic system and pain threshold in PD patients. We included 25 PD patients with various intensities of central pain (visual analog scale). Read More

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http://dx.doi.org/10.1007/s00702-019-01974-5DOI Listing

Long-term, open-label, phase 3 study of rasagiline in Japanese patients with early Parkinson's disease.

J Neural Transm (Vienna) 2019 Mar 28;126(3):299-308. Epub 2019 Jan 28.

Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Rasagiline is a monoamine oxidase B inhibitor with demonstrated efficacy and safety in patients with Parkinson's disease (PD). We recently conducted the first randomized, double-blind, placebo-controlled trial of rasagiline in Japanese patients with early PD and now report the results of its open-label extension (clinicaltrials.gov, NCT02337751). Read More

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http://dx.doi.org/10.1007/s00702-018-1964-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449288PMC

Longterm outcome of cognition, affective state, and quality of life following subthalamic deep brain stimulation in Parkinson's disease.

J Neural Transm (Vienna) 2019 Mar 25;126(3):309-318. Epub 2019 Jan 25.

Department of Neurology and Stereotactic Neurosurgery, Otto-von-Guericke-University, Magdeburg, Germany.

Normal cognition is an established selection criteria for subthalamic (STN) deep brain stimulation (DBS) in Parkinson's disease (PD), while concern has been raised as to aggravated cognitive decline in PD patients following STN-DBS. The present longterm study investigates cognitive status in all patients (n = 104) suffering from PD, who were treated via continuous bilateral STN-DBS between 1997 and 2006 in a single institution. Preoperative neuropsychological results were available in 79/104 of the patients. Read More

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http://dx.doi.org/10.1007/s00702-019-01972-7DOI Listing
March 2019
9 Reads

Towards pharmacogenetic-based treatment in psychiatry.

J Neural Transm (Vienna) 2019 Jan;126(1):1-3

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s00702-018-01968-9
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http://dx.doi.org/10.1007/s00702-018-01968-9DOI Listing
January 2019
8 Reads

Mesencephalic and extramesencephalic dopaminergic systems in Parkinson's disease.

J Neural Transm (Vienna) 2019 Apr 14;126(4):377-396. Epub 2019 Jan 14.

Department of Neurology, Philipps University Marburg, Baldingerstraße 1, 35043, Marburg, Germany.

Neurodegeneration of the nigrostriatal dopaminergic system and concurrent dopamine (DA) deficiency in the basal ganglia represent core features of Parkinson's disease (PD). Despite the central role of DA in the pathogenesis of PD, dopaminergic systems outside of the midbrain have not been systematically investigated for Lewy body pathology or neurodegeneration. Dopaminergic neurons show a surprisingly rich neurobiological diversity, suggesting that there is not one general type of dopaminergic neuron, but rather a spectrum of different dopaminergic phenotypes. Read More

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http://dx.doi.org/10.1007/s00702-019-01970-9DOI Listing
April 2019
3 Reads

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment.

J Neural Transm (Vienna) 2019 Apr 14;126(4):455-471. Epub 2019 Jan 14.

Department of Neuroscience, Karolinska Institutet, Biomedicum, B0851, Solnavägen 9, 17177, Stockholm, Sweden.

The adenosine homo, iso and heteroreceptor complexes in the basal ganglia play a highly significant role in modulating the indirect and direct pathways and the striosomal projections to the nigro-striatal DA system. The major adenosine receptor complexes in the striato-pallidal GABA neurons can be the A2AR-D2R and A2AR-D2R-mGluR5 receptor complexes, in which A2AR protomers and mGluR5 protomers can allosterically interact to inhibit D2R protomer signaling. Through a reorganization of these heteroreceptor complexes upon chronic dopaminergic treatment a pathological and prolonged inhibition of D2R receptor protomer signaling can develop with motor inhibition and wearing off of the therapeutic effects of levodopa and dopamine receptor agonists. Read More

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http://dx.doi.org/10.1007/s00702-019-01969-2DOI Listing
April 2019
2 Reads

Long-term safety and efficacy of adjunctive rasagiline in levodopa-treated Japanese patients with Parkinson's disease.

J Neural Transm (Vienna) 2019 Mar 11;126(3):289-297. Epub 2019 Jan 11.

Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Rasagiline is a monoamine oxidase type-B inhibitor in development in Japan for Parkinson's disease (PD). This open-label study evaluated the long-term safety and efficacy of rasagiline in Japanese patients with PD receiving levodopa. Patients were aged 30-79 years and had wearing-off or weakened effect. Read More

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http://dx.doi.org/10.1007/s00702-018-1962-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449487PMC
March 2019
1 Read

Imaging stress: an overview of stress induction methods in the MR scanner.

J Neural Transm (Vienna) 2019 Jan 10. Epub 2019 Jan 10.

Department of Psychiatry and Psychotherapy, Medical School, University of Tübingen, Calwerstrasse 14, 72076, Tübingen, Germany.

Processing of acute stress has potential implications for mental and physical health. At the same time, individuals differ largely in how strongly they react to stress. Neuroimaging paradigms have been developed to characterize the neural underpinnings of the stress response in general and to understand the mechanisms that differentiate high and low susceptible individuals. Read More

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http://dx.doi.org/10.1007/s00702-018-01965-yDOI Listing
January 2019
1 Read

Acute and chronic methylphenidate administration in intact and VTA-specific and nonspecific lesioned rats.

J Neural Transm (Vienna) 2019 Feb 8;126(2):173-182. Epub 2019 Jan 8.

Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, McGovern Medical School, 6431 Fannin Street, Houston, TX, 77030, USA.

Methylphenidate (MPD) is a psychostimulant used for the treatment of ADHD and works by increasing the bioavailability of dopamine (DA) in the brain. As a major source of DA, the ventral tegmental area (VTA) served as the principal target in this study as we aimed to understand its role in modulating the acute and chronic MPD effect. Forty-eight male Sprague-Dawley rats were divided into control, sham, electrical lesion, and 6-OHDA lesion groups. Read More

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http://dx.doi.org/10.1007/s00702-018-1963-4DOI Listing
February 2019
1 Read

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression.

J Neural Transm (Vienna) 2019 Jan 4;126(1):35-45. Epub 2019 Jan 4.

Discipline of Psychiatry, School of Medicine, University of Adelaide, North Terrace, Adelaide, SA, 5005, Australia.

Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants for the treatment of major depressive disorder (MDD). However, treatment response during an initial therapeutic trial is often poor and is difficult to predict. Heterogeneity of response to SSRIs in depressed patients is partly driven by co-occurring somatic disorders such as coronary artery disease (CAD) and obesity. Read More

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http://dx.doi.org/10.1007/s00702-018-01966-xDOI Listing
January 2019
7 Reads
2.402 Impact Factor

Botulinum neurotoxin a therapy efficacy and safety for oromandibular dystonia: a meta-analysis.

J Neural Transm (Vienna) 2019 Feb 2;126(2):141-148. Epub 2019 Jan 2.

Movement Disorders Section, Department of Neurology, Hannover Medical School, Hannover, Germany.

Oromandibular dystonia (OMD) is a focal dystonia involving the mouth, jaw, and tongue. Botulinum neurotoxin (BoNT) therapy might be one form of treatment in OMD. Systematic pooling of BoNT studies in OMD remains wanting, as the derived data could provide useful information in regard to efficacy and safety issues. Read More

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http://dx.doi.org/10.1007/s00702-018-1960-7DOI Listing
February 2019
7 Reads

Dopamine and addiction: what have we learned from 40 years of research.

J Neural Transm (Vienna) 2019 Apr 19;126(4):481-516. Epub 2018 Dec 19.

Université de Poitiers, INSERM, U-1084, Laboratoire de Neurosciences Expérimentales et Cliniques, Poitiers, France.

Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known. The critical role of DA in addiction is supported by converging evidence that has been accumulated in the last 40 years. In the present review, first we describe the dopaminergic system in terms of connectivity, functioning and involvement in reward processes. Read More

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http://link.springer.com/10.1007/s00702-018-1957-2
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http://dx.doi.org/10.1007/s00702-018-1957-2DOI Listing
April 2019
21 Reads

Oxytocin reactivity to an emotional challenge paradigm and its relation to social-cognitive functions in healthy volunteers.

J Neural Transm (Vienna) 2019 Feb 11;126(2):211-218. Epub 2018 Dec 11.

Department of Psychiatry Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinenstr 1-3, 44791, Bochum, Germany.

The neuropeptide oxytocin (OT) is known to be an important modulator of social cognition. It has been shown that lower OT plasma concentrations are linked to impairments in social cognition. Studies have also shown that intranasal OT may enhance social-cognitive abilities in healthy subjects. Read More

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http://dx.doi.org/10.1007/s00702-018-1955-4DOI Listing
February 2019
2 Reads

Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.

J Neural Transm (Vienna) 2019 Feb 8;126(2):115-122. Epub 2018 Dec 8.

Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.

Increasing evidence indicates that some antiarrhythmic drugs play a pivotal role in seizures, not only in vivo studies on animals, but also in clinical trials. Some of these antiarrhythmic drugs potentiate or alleviate the anticonvulsant action of the classical antiepileptic drugs. The aim of this study was to determine the influence of dronedarone (DRO-a multichannel blocker belonging to the class III of antiarrhythmic drugs) on the anticonvulsant effects of four standard antiepileptic drugs (carbamazepine, phenobarbital, phenytoin and valproate) in the tonic-clonic seizure model in mice. Read More

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http://dx.doi.org/10.1007/s00702-018-1940-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373245PMC
February 2019
2 Reads

Complexity of electrocortical activity as potential biomarker in untreated Parkinson's disease.

J Neural Transm (Vienna) 2019 Feb 3;126(2):167-172. Epub 2018 Dec 3.

Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", Università degli Studi di Catania, Via Santa Sofia 78, 95123, Catania, Italy.

In Parkinson's disease (PD), the identification of instrumental biomarkers is crucial to evaluate disease susceptibility and motor stage. We evaluated self-similarity of electrocortical activity as expression of brain signal complexity in untreated PD, to investigate its possible role as a neurophysiological biomarker. We analyzed the data of 34 untreated PD subjects and 18 group-matched controls who underwent standardized electroencephalography. Read More

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http://dx.doi.org/10.1007/s00702-018-1961-6DOI Listing
February 2019
3 Reads

Headache in the course of multiple sclerosis: a prospective study.

J Neural Transm (Vienna) 2019 Feb 30;126(2):131-139. Epub 2018 Nov 30.

Neuroimmunological Section, Department of Neurology, University of Rostock, Rostock, Germany.

Multiple sclerosis (MS) is the most common immune-mediated inflammatory disease of the central nervous system (CNS). Early diagnosis and treatment is important to prevent progression of disability in the course of the chronic disease. Therefore, correct and fast identification of early symptoms is vital. Read More

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http://dx.doi.org/10.1007/s00702-018-1959-0DOI Listing
February 2019
4 Reads

Feasibility of NIRS-based neurofeedback training in social anxiety disorder: behavioral and neural correlates.

J Neural Transm (Vienna) 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstr.14, 72076, Tübingen, Germany.

Attention biases towards threat signals have been linked to the etiology and symptomatology of social anxiety disorder (SAD). Dysfunction of the dorsolateral prefrontal cortex (dlPFC) may contribute to attention biases in anxious individuals. The aim of this study was to investigate the feasibility of near-infrared spectroscopy (NIRS) neurofeedback (NF) training-targeting the dlPFC-and its effects on threat-related attention biases of individuals with SAD. Read More

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http://link.springer.com/10.1007/s00702-018-1954-5
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http://dx.doi.org/10.1007/s00702-018-1954-5DOI Listing
November 2018
8 Reads

Disease duration in E200K familial Creutzfeldt-Jakob disease is correlated with clinical, radiological, and laboratory variables.

J Neural Transm (Vienna) 2018 Nov 29. Epub 2018 Nov 29.

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Previous studies have suggested that disease duration in Creutzfeldt-Jakob disease (CJD) may be related to the radiological findings or cerebrospinal fluid (CSF) tau levels; however, it is not yet established whether clinical, radiological, and laboratory findings at diagnosis can predict survival or have a prognostic value. The aim of this study was to examine whether the disease duration is correlated with clinical, radiological, and laboratory variables. The study population consisted of consecutive familial CJD (fCJD) patients that were assessed within 1 week from the diagnosis including the CJD neurological scale (CJD-NS), Minimental Status Examination, Frontal Assessment Battery, NIH Stroke Scale, and the expanded disability status scale. Read More

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http://link.springer.com/10.1007/s00702-018-1958-1
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http://dx.doi.org/10.1007/s00702-018-1958-1DOI Listing
November 2018
21 Reads

Correction to: Tyrosine-hydroxylase immunoreactivity in the mouse transparent brain and adrenal glands.

J Neural Transm (Vienna) 2018 Nov 17. Epub 2018 Nov 17.

Institut de la Vision, Sorbonne Université, INSERM CNRS UMRS 968, Paris, France.

Unfortunately, the given name and family name of the fourth author was incorrectly tagged in the xml data, therefore it is abbreviated wrongly as ''Goazigo AR'' in Pubmed. The correct given name is Annabelle and family name is Reaux‑Le Goazigo. Read More

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http://link.springer.com/10.1007/s00702-018-1956-3
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http://dx.doi.org/10.1007/s00702-018-1956-3DOI Listing
November 2018
15 Reads