2,772 results match your criteria Journal of Nephrology[Journal]


Lipopolysaccharide in systemic circulation induces activation of inflammatory response and oxidative stress in cardiorenal syndrome type 1.

J Nephrol 2019 Apr 20. Epub 2019 Apr 20.

Department of Nephrology, Dialysis and Transplantation, St Bortolo Hospital, International Renal Research Institute Vicenza, Via Rodolfi, 37, 36100, Vicenza, Italy.

Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury. In this study, we evaluate the role of lipopolysaccharide (LPS) and various inflammatory markers in the developing acute kidney injury (AKI) in acute heart failure (AHF) patients.

Methods: We enrolled 31 AHF patients and 20 CRS type 1 (the cause of AKI was presumed to be related to cardiac dysfunction) and 17 healthy volunteers without AHF, AKI or CKD, as control group (CTR). Read More

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http://dx.doi.org/10.1007/s40620-019-00613-2DOI Listing

Incremental hemodialysis, a valuable option for the frail elderly patient.

J Nephrol 2019 Apr 19. Epub 2019 Apr 19.

Department of Nephrology and Dialysis, Research Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.

Management of older people on dialysis requires focus on the wider aspects of aging as well as dialysis. Recognition and assessment of frailty is vital in changing our approach in elderly patients. Current guidelines in dialysis have a limited evidence base across all age group, but particularly the elderly. Read More

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http://dx.doi.org/10.1007/s40620-019-00611-4DOI Listing
April 2019
3 Reads
1.996 Impact Factor

New mineralocorticoid receptor antagonists: update on their use in chronic kidney disease and heart failure.

J Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, Via Massarenti 9, 40100, Bologna, Italy.

Aldosterone is a mineralocorticoid hormone with a well-known effect on the renal tubule leading to water retention and potassium reabsorption. Other major effects of the hormone include the induction of proinflammatory activity that leads to progressive fibrotic damage of the target organs, heart and kidney. Blocking the aldosterone receptor therefore represents an important pharmacological strategy to avoid the clinical conditions deriving from heart failure (CHF) and chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1007/s40620-019-00600-7DOI Listing
April 2019
1 Read

Interferon-free regimens improve kidney function in patients with chronic hepatitis C infection.

J Nephrol 2019 Apr 11. Epub 2019 Apr 11.

Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Background And Aim: The impact of directly acting antiviral agent (DAA) regimens on renal function is not well defined and quite controversial. We evaluated the effect of DAAs on kidney function and the factors associated with an improvement or worsening.

Patients And Methods: The changes in estimated glomerular filtration rate (eGFR) in a cohort of 403 patients treated with a DAA regimen were evaluated. Read More

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http://dx.doi.org/10.1007/s40620-019-00608-zDOI Listing
April 2019
2 Reads

Role of anemia and proteinuria in the development of subsequent renal function deterioration in a general population with preserved glomerular filtration rate: a community-based cohort study.

J Nephrol 2019 Apr 6. Epub 2019 Apr 6.

The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.

Background: Risk factors for renal function deterioration in the general population are not fully understood. We aimed to clarify the determinants of estimated glomerular filtration rate (eGFR) decline using a community-based cohort.

Methods And Results: Among 3217 subjects who underwent repeated health check-ups, we excluded 478 subjects with eGFR ≤ 60 mL/min/1. Read More

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http://dx.doi.org/10.1007/s40620-019-00605-2DOI Listing
April 2019
2 Reads

Catheter-related infections in peritoneal dialysis: comparison of a single center results and the literature data.

J Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Via Rodolfi, 37, 36100, Vicenza, Italy.

Background: Catheter-related infections are important causes of morbidity in patients undergoing peritoneal dialysis (PD). There are different protocols of exit site care for the prevention of catheter-related infections. The aim of this study was to evaluate the incidence of catheter-related infections and their complications in our PD center. Read More

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http://dx.doi.org/10.1007/s40620-019-00604-3DOI Listing
April 2019
2 Reads

Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial.

J Nephrol 2019 Apr 4. Epub 2019 Apr 4.

Nephrology Department, Hospital General Universitario Gregorio Marañón, C/Dr Esquerdo 46, 28007, Madrid, Spain.

Background: Pentoxifylline could reduce proteinuria and slow renal disease progression. We previously conducted a single-blind, randomized, controlled trial that showed that pentoxifylline decreases inflammatory markers and stabilizes renal function.

Setting And Participants: 91 participants (46 in the pentoxifylline group and 45 in the control group) followed up for 7 additional years. Read More

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http://dx.doi.org/10.1007/s40620-019-00607-0DOI Listing
April 2019
3 Reads

Acute dialysis in children: results of a European survey.

J Nephrol 2019 Jun 4;32(3):445-451. Epub 2019 Apr 4.

Nephrology and Dialysis Unit, Pediatric Subspecialties Department, Institute for Scientific Research, Bambino Gesù Children's Hospital, Piazza S. Onofrio 4, 00165, Rome, Italy.

The number of children with acute kidney injury (AKI) requiring dialysis is increasing. To date, systematic analysis has been largely limited to critically ill children treated with continuous renal replacement therapy (CRRT). We conducted a survey among 35 European Pediatric Nephrology Centers to investigate dialysis practices in European children with AKI. Read More

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http://dx.doi.org/10.1007/s40620-019-00606-1DOI Listing
June 2019
3 Reads
1.996 Impact Factor

Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker use prior to medical intensive care unit admission and in-hospital mortality: propensity score-matched cohort study.

J Nephrol 2019 Apr 1. Epub 2019 Apr 1.

Division of Nephrology, Department of Medicine, St. Luke's International Hospital, Tokyo, Japan.

Background: The aim of this study was to evaluate whether angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker (ACEI/ARB) use prior to medical intensive care unit (ICU) admission was associated with in-hospital mortality and length of ICU stay.

Methods: A propensity score-matched cohort study was conducted at single center from 2004 to 2016. We included all adult patients who were admitted to the ICU due to internal medicine-related conditions. Read More

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http://dx.doi.org/10.1007/s40620-019-00603-4DOI Listing
April 2019
1 Read

Prevention of complications from use of conventional immunosuppressants: a critical review.

J Nephrol 2019 Mar 29. Epub 2019 Mar 29.

The David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the drug should be dosed carefully and the patient monitored frequently. In this review, we consider the categories of synthetic immunosuppressive agents more frequently and conventionally used in clinical nephrology: glucocorticoids, Aalkylating agents (cyclophosphamide, chlorambucil), purine synthesis inhibitors (azathioprine, mycophenolate salts) and calcineurin inhibitors (cyclosporine, tacrolimus). Read More

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http://dx.doi.org/10.1007/s40620-019-00602-5DOI Listing

Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.

J Nephrol 2019 Mar 19. Epub 2019 Mar 19.

Department of Nephrology, Institute of Nephrology of Chongqing and Kidney Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China.

Background: Previous studies reported that magnesium deficiency was associated with vascular calcifications, atherosclerosis and cardiovascular disease, which might play an independent pathogenic role in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. However, the results of these studies were somewhat underpowered and inconclusive.

Methods: Literature was identified by searching PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL). Read More

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http://dx.doi.org/10.1007/s40620-019-00601-6DOI Listing
March 2019
2 Reads

Home haemodialysis: how it began, where it went wrong, and what it may yet be.

J Nephrol 2019 Jun 19;32(3):331-333. Epub 2019 Mar 19.

Service de Nephrologie, Centre Hospitalier Le Mans, Le Mans, France.

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http://dx.doi.org/10.1007/s40620-019-00597-zDOI Listing

Antiplatelet therapy for prevention of hemodialysis vascular access thrombosis and improving survival.

J Nephrol 2019 Mar 19. Epub 2019 Mar 19.

Nephrology and Dialysis Unit, ASST Fatebenefratelli Sacco, Milano, Italy.

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http://dx.doi.org/10.1007/s40620-019-00598-yDOI Listing

Cholecalciferol supplementation increases FGF23 in peritoneal dialysis patients with hypovitaminosis D: a randomized clinical trial.

J Nephrol 2019 Mar 19. Epub 2019 Mar 19.

Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Dominguez Sección XVI, 14080, Mexico City, Mexico.

Background: Vitamin D deficiency is common in peritoneal dialysis (PD) patients, so its supplementation has been advocated as potentially beneficial.

Methods: Double-blind, placebo-controlled, randomized clinical trial. Subjects on PD treated with high calcium peritoneal dialysate (Ca 3. Read More

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http://dx.doi.org/10.1007/s40620-019-00599-xDOI Listing
March 2019
1.996 Impact Factor

Nephrology in the global environment.

J Nephrol 2019 Apr 22;32(2):163-164. Epub 2019 Feb 22.

Service de Nephrologie, Centre Hospitalier Le Mans, Le Mans, France.

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http://dx.doi.org/10.1007/s40620-019-00596-0DOI Listing

Renal response to an oral protein load in patients with central diabetes insipidus before and after treatment with vasopressin.

J Nephrol 2019 Jun 19;32(3):411-415. Epub 2019 Feb 19.

Division of Nephrology, Department of Scienze mediche traslazionali, Università della Campania "L. Vanvitelli", Padiglione 17, via Pansini 5, 80131, Naples, Italy.

Aim: Different factors have been hypothesized to play a role in the cascade of events associated with the protein-induced glomerular response. However, scant data are available on the possible functional effect of vasopressin (VP) on the glomerular filtration rate (GFR) in humans with central diabetes insipidus (CDI), which was the aim of the present study.

Method: Renal function was studied under fasting conditions (baseline) and after a meat meal in 16 patients with CDI before and after treatment with desmopressin (DDAVP) and in 16 control subjects. Read More

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http://dx.doi.org/10.1007/s40620-018-00575-xDOI Listing
June 2019
3 Reads

A cardiac magnetic resonance imaging study of long-term and incident hemodialysis patients.

J Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.

Background: The cardiovascular morphology and function in long-term survivors of hemodialysis are not well described.

Methods: Single-center cross-sectional study nested within a prospective cohort study of 15 long-term (> 7.5 years) and 15 matched incident (< 6 months) hemodialysis patients with 15 external matched controls. Read More

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http://dx.doi.org/10.1007/s40620-019-00593-3DOI Listing
February 2019
1 Read

Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus.

J Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory Medicine Unit, Department of Medicine, University of Padova, Padua, Italy.

Background And Aims: Diabetes mellitus is recognized as one of the major causes of end stage kidney disease. Bone Gla protein (BGP) is a vitamin K-dependent protein involved in bone mineralization and vascular calcifications (VC). Our goal was to characterize BGP and undercarboxylated BGP (ucBGP) in DM patients on HD, compared to HD patients without DM, and their association with vascular and bone disease. Read More

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http://dx.doi.org/10.1007/s40620-019-00595-1DOI Listing
February 2019
1 Read

Burden, access, and disparities in kidney disease.

J Nephrol 2019 Feb;32(1):1-8

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1007/s40620-019-00590-6DOI Listing
February 2019
3 Reads

C-reactive protein velocity and the risk of acute kidney injury among ST elevation myocardial infarction patients undergoing primary percutaneous intervention.

J Nephrol 2019 Jun 31;32(3):437-443. Epub 2019 Jan 31.

Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman St, Tel Aviv, 64239, Israel.

Background: Elevated C-reactive protein (CRP) was shown to be associated with an increased risk for acute kidney injury (AKI) in ST elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI), however, the optimal time frame to measure CRP for risk stratification is not known. We evaluated the relation between the change in CRP over time (CRP velocity-CRPv) and AKI among STEMI patients treated with primary PCI.

Methods: We included 801 STEMI who presented between 2007 and 2017 and had their CRP measured with a wide range assay (wr-CRP) at least twice during the 24 h after admission. Read More

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http://dx.doi.org/10.1007/s40620-019-00594-2DOI Listing

Recurrent urinary tract infections in kidney transplant recipients during the first-year influence long-term graft function: a single-center retrospective cohort study.

J Nephrol 2019 Jan 30. Epub 2019 Jan 30.

Department of Emergency and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy.

Urinary tract infections (UTIs) after kidney transplantation are associated with significant morbidity. However, data on the impact of UTI on graft survival are controversial. We conducted a retrospective cohort study of 380 kidney transplant patients. Read More

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http://dx.doi.org/10.1007/s40620-019-00591-5DOI Listing
January 2019
3 Reads

Anticoagulation in CKD and ESRD.

J Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Medicine, University of Calgary, Calgary, AB, Canada.

In this review we discuss the evolving literature of anticoagulation in the context of the nephrology patient. Whereas CKD patients with atrial fibrillation, should be anticoagulated, the benefit of anticoagulation for those on dialysis remains controversial due to an increased risk of bleeding. The availability of direct oral anticoagulants offers new options for those with CKD. Read More

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http://dx.doi.org/10.1007/s40620-019-00592-4DOI Listing
January 2019

Updates on urinary tract infections in kidney transplantation.

J Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, 'Aldo Moro' University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy.

Urinary tract infection (UTI) represents the most common infection after kidney transplantation; it is associated with an increased risk for acute kidney rejection and impaired graft function in the early post-transplant period. Kidney transplant recipients with UTIs are often clinically asymptomatic due to the immunosuppressive therapy; however, asymptomatic bacteriuria may progress to acute pyelonephritis, bacteremia and urosepsis, particularly in the early post-transplant period, that are independent risk factors for short and long-term graft and patient survival. This article reviews the definitions, incidence, risk factors and the management of UTI in kidney transplant recipients; furthermore, the main controversial and still unanswered questions, regarding the causes of recurrent UTIs, adequate use of antibiotics to avoid antibiotic resistance, dosing and timing for prophylaxis and treatment of symptomatic infections, are also discussed. Read More

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http://dx.doi.org/10.1007/s40620-019-00585-3DOI Listing
January 2019
20 Reads

Meeting report of the "Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017".

J Nephrol 2019 Jan 24. Epub 2019 Jan 24.

Department of Internal Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, genetics, pathological, as well as clinical and research topics. The participants included clinicians and recognized experts in the field from Europe and the United States interacted closely during the symposium which promoted a chance to explore new frontiers in the field of kidney stone disease. Read More

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http://dx.doi.org/10.1007/s40620-019-00587-1DOI Listing
January 2019
6 Reads

The role of the intestinal microbiota in uremic solute accumulation: a focus on sulfur compounds.

J Nephrol 2019 Jan 23. Epub 2019 Jan 23.

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", Via Luigi de Crecchio 7, 80138, Naples, Italy.

The gut microbiota is considered to be a novel important factor to take into account in the pathogenesis of chronic kidney disease and uremia. Much attention has been paid to specific uremic retention solutes of microbial origin, such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide. However, other novel less well studied compounds, such as hydrogen sulfide and related sulfur metabolites (sulfane sulfur, lanthionine, etc. Read More

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http://dx.doi.org/10.1007/s40620-019-00589-zDOI Listing
January 2019
2 Reads

Generalizability of SPRINT-CKD cohort to CKD patients referred to renal clinics.

J Nephrol 2019 Jun 23;32(3):429-435. Epub 2019 Jan 23.

Division of Nephrology, Department of Scienze Mediche e Chirurgiche Avanzate, University of Campania "Luigi Vanvitelli", Via M. Longo 50, 80138, Naples, Italy.

Background: The Systolic Blood Pressure Intervention Trial-CKD substudy (SPRINT-CKD) has suggested a lower blood pressure (BP) target in CKD patients. However, it is questionable whether the SPRINT-CKD results may be generalized to CKD patients under nephrology care.

Methods: To compare SPRINT-CKD cohort versus referred CKD patients in terms of patients' risk profile and outcomes, we pooled four prospective cohorts of consecutive CKD patients referred to 40 Italian renal clinics. Read More

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http://dx.doi.org/10.1007/s40620-019-00588-0DOI Listing
June 2019
2 Reads

Cyclooxygenase 2 inhibition slows disease progression and improves the altered renal lipid mediator profile in the Pkd2 mouse model of autosomal dominant polycystic kidney disease.

J Nephrol 2019 Jun 22;32(3):401-409. Epub 2019 Jan 22.

Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada.

Background: Increased levels of cyclooxygenase (COX) derived oxylipins is the earliest and most consistent alteration in the renal oxylipin profile in diverse models of cystic kidney diseases. Therefore, we examined whether a COX2 inhibitor would reduce disease progression in the Pkd2 mouse model of autosomal dominant polycystic kidney disease (ADPKD).

Methods: Weanling normal and diseased male Pkd2 mice were provided diets that provided 0 or 50 mg celecoxib/kg body weight/day, for 13 weeks. Read More

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http://dx.doi.org/10.1007/s40620-018-00578-8DOI Listing
June 2019
1 Read

Improving the appropriateness of depression treatment in patients with advanced chronic kidney disease.

J Nephrol 2019 Jan 22. Epub 2019 Jan 22.

Laboratory «Movement, Interactions, Performance» (E.A. 4334), University of Nantes, 25 Bis Boulevard Guy Mollet, BP 72206, 44322, Nantes Cedex 3, France.

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http://dx.doi.org/10.1007/s40620-018-00564-0DOI Listing
January 2019

Hemodialysis access type is associated with blood pressure variability and echocardiographic changes in end-stage renal disease patients.

J Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Department of Nephrology, West China Hospital, Sichuan University, Guoxue Alley No.37, Chengdu, 610041, Sichuan Province, China.

Arteriovenous fistula (AVF) strategy has been recommended in clinical guidelines for a long time due to the survival benefits associated with it. However, the underlying mechanism still needs to be explored. This retrospective cohort study included 611 patients who received hemodialysis in West China Hospital Medical Center between January 1, 2014 and December 31, 2014. Read More

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http://link.springer.com/10.1007/s40620-018-00574-y
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http://dx.doi.org/10.1007/s40620-018-00574-yDOI Listing
January 2019
9 Reads

Beyond chronic kidney disease: the diagnosis of Renal Disease in the Elderly as an unmet need. A position paper endorsed by Italian Society of Nephrology (SIN) and Italian Society of Geriatrics and Gerontology (SIGG).

J Nephrol 2019 Apr 18;32(2):165-176. Epub 2019 Jan 18.

Unit of Geriatrics, Campus Bio-Medico University, Rome, Italy.

The dramatic increase in prevalence of chronic kidney disease (CKD) with ageing makes the recognition and correct referral of these patients of paramount relevance in order to implement interventions preventing or delaying the development of CKD complications and end-stage renal disease. Nevertheless, several issues make the diagnosis of CKD in the elderly cumbersome. Among these are age related changes in structures and functions of the kidney, which may be difficult to distinguish from CKD, and multimorbidity. Read More

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http://dx.doi.org/10.1007/s40620-019-00584-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423311PMC
April 2019
2 Reads

Effects of intradialytic aerobic exercise on hemodialysis patients: a systematic review and meta-analysis.

J Nephrol 2019 Jan 18. Epub 2019 Jan 18.

School of Public Health and Primary Care, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Objective: Intradialytic exercise (IDE) is not yet a routine practice for hemodialysis patients, the lack of guidelines supporting it being a major reason. This systematic review and meta-analysis of aerobic IDE interventions examined the efficacy of IDE regarding quality of life (QOL), serum phosphorus, dialysis efficiency, inflammatory status, vitamin D3, parathyroid hormone, intake of phosphate binders, mortality and hospitalization rate.

Methods: Pubmed, Medline (Ovid), Embase (Ovid), Cochrane, and Cinahl (EBSCO) databases were searched to retrieve studies up to June 12, 2018. Read More

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http://dx.doi.org/10.1007/s40620-018-00565-zDOI Listing
January 2019
2 Reads

The PIRP project (Prevenzione Insufficienza Renale Progressiva): how to integrate hospital and community maintenance treatment for chronic kidney disease.

J Nephrol 2019 Jun 18;32(3):417-427. Epub 2019 Jan 18.

Nephrology and Dialysis Unit, Ospedale S. Maria della Scaletta, Imola, Italy.

Chronic kidney disease (CKD) represents a global health burden with great economic impact on healthcare and therefore it requires appropriate interventions by Health Care Systems. The PIRP (Prevenzione Insufficienza Renale Progressiva) project is endorsed and funded by the Emilia-Romagna Regional Health Board and involves all the Nephrology Units of the Emilia-Romagna Region (Italy). The project has a predominantly clinical purpose and is expected to bring about a continuous quality improvement in the treatment of patients with CKD. Read More

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http://link.springer.com/10.1007/s40620-018-00570-2
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http://dx.doi.org/10.1007/s40620-018-00570-2DOI Listing
June 2019
9 Reads

Exercise training in kidney transplant recipients: a systematic review.

J Nephrol 2019 Jan 16. Epub 2019 Jan 16.

Division of Nephrology, Dialysis and Transplantation, Nephrology Unit, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.

Background And Aims: Evidences on the benefits of physical exercise in kidney transplant patients (KTx) are not conclusive and concerns on safety remain. We here gather and interpret current evidence on the benefits/harms of exercise training intervention in KTx.

Methods: Systematic review of exercise training programs in KTx. Read More

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http://dx.doi.org/10.1007/s40620-019-00583-5DOI Listing
January 2019
2 Reads

Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic.

J Nephrol 2019 Jan 11. Epub 2019 Jan 11.

Department of Surgery, Austin Health, The University of Melbourne, Studley Rd., Heidelberg, VIC, 3084, Australia.

Acute kidney injury (AKI) as a result of ischaemia-reperfusion represents a major healthcare burden worldwide. Mortality rates from AKI in hospitalized patients are extremely high and have changed little despite decades of research and medical advances. In 1986, Murry et al. Read More

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http://dx.doi.org/10.1007/s40620-019-00582-6DOI Listing
January 2019
1 Read

Sodium removal and plasma tonicity balance are not different in hemodialysis and hemodiafiltration using high-flux membranes.

J Nephrol 2019 Jun 10;32(3):461-469. Epub 2019 Jan 10.

Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy.

Background: The clinical benefits of on-line hemodiafiltration (HDF) versus high-flux membranes hemodialysis (hf-HD) are still debated. In fact, although a superiority of one treatment over the other, especially in terms of mortality, did not emerge from the analysis of clinical trials, improved intradialytic vascular stability and cardiovascular mortality have been observed in patients undergoing HDF rather than hf-HD; the lower removal of sodium (Na) during HDF seems to play a major role. The plasma concentration of Na is the major determinant of plasma tonicity, which, by determining the flow of water between the intracellular and the extracellular compartment, contributes to the vascular refilling process and the maintenance of blood pressure during the hemodialysis treatment. Read More

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http://dx.doi.org/10.1007/s40620-018-00581-zDOI Listing
June 2019
1 Read

Novel markers of graft outcome in a cohort of kidney transplanted patients: a cohort observational study.

J Nephrol 2019 Feb 10;32(1):139-150. Epub 2019 Jan 10.

Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione Istituto di Ricerca e Cura a Carattere Scientifico Cà Granda Ospedale Maggiore Policlinico, Via Commenda 15, 20122, Milan, Italy.

Renal biopsy (RBx) informs about kidney transplantation (KTx) prognosis. In our observational study the prevalence of histological anomalies and the prognostic role of CD45, vimentin (VIM) and periostin (POSTN) in KTx-RBx have been evaluated. One hundred forty-six KTx-RBx (2009-2012) were analysed for general histology and in immunohistochemistry for CD45, VIM and POSTN. Read More

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http://dx.doi.org/10.1007/s40620-018-00580-0DOI Listing
February 2019
1 Read

Transplant waitlisting attenuates the association between hemodialysis access type and mortality.

J Nephrol 2019 Jun 2;32(3):477-485. Epub 2019 Jan 2.

University of California San Diego, San Diego, CA, USA.

Prior studies have shown that beginning hemodialysis (HD) with a hemodialysis catheter (HC) is associated with worse mortality than with an arteriovenous fistula (AVF) or arteriovenous graft (AVG). We hypothesized that transplant waitlisting would modify the effect of HD access on mortality, given waitlist candidates' more robust health status. Using the US Renal Data System, we studied patients with incident ESRD who initiated HD between 2010 and 2015 with an AVF, AVG, or HC. Read More

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http://dx.doi.org/10.1007/s40620-018-00572-0DOI Listing
June 2019
11 Reads

How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network.

J Nephrol 2019 Apr 2;32(2):323-330. Epub 2019 Jan 2.

Pathology Unit, S. Orsola-Malpighi University Hospital of Bologna, Bologna, Italy.

Guidelines for donor selection have changed to expand the donor pool, considering potential donors affected by a neoplasm. Aim of this retrospective study is to look at the use of organs from donors with a current or history of neoplasm within the Italian Transplant Network. Data, collected and validated by Italian National Health Institute for the time interval 2006-2015, have been reviewed retrospectively by mean of multivariable pivot tables. Read More

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http://dx.doi.org/10.1007/s40620-018-00573-zDOI Listing
April 2019
2 Reads

Incremental dialysis in ESRD: systematic review and meta-analysis.

J Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Division of Nephrology, Department of Scienze Mediche e Chirurgiche Avanzate, University of Campania "Luigi Vanvitelli", Via M. Longo 50, 80138, Naples, Italy.

Background: Incremental dialysis may preserve residual renal function and improve survival in comparison with full-dose dialysis; however, available evidence is limited. We therefore compared all-cause mortality and residual kidney function (RKF) loss in incremental and full-dose dialysis and time to full-dose dialysis in incremental hemodialysis (IHD) and incremental peritoneal dialysis (IPD).

Methods: We performed a systematic review and meta-analysis of cohort studies of adults with ESRD starting IHD and IPD. Read More

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http://link.springer.com/10.1007/s40620-018-00577-9
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http://dx.doi.org/10.1007/s40620-018-00577-9DOI Listing
January 2019
5 Reads

Fertility and reproductive care in chronic kidney disease.

J Nephrol 2019 Feb 2;32(1):39-50. Epub 2019 Jan 2.

Department of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.

In both women and men, chronic kidney disease (CKD) is associated with decreased fertility. Though a multitude of factors contribute to the reduction in fertility in this population, progressively impaired function of the hypothalamic-pituitary-gonadal axis appears to play a key role in the pathophysiology. There is limited research on strategies to manage infertility in the CKD population, but intensive hemodialysis, kidney transplantation, medication management and assisted reproductive technologies (ART) have all been proposed. Read More

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http://link.springer.com/10.1007/s40620-018-00569-9
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http://dx.doi.org/10.1007/s40620-018-00569-9DOI Listing
February 2019
4 Reads

Safety and efficacy of heparin during dialysis in the context of systemic anticoagulant and antiplatelet medications.

J Nephrol 2019 Jun 2;32(3):453-460. Epub 2019 Jan 2.

DaVita Kidney Care, Denver, CO, USA.

Heparin is widely used to prevent coagulation during hemodialysis. Although systemic anticoagulants and antiplatelet agents are commonly prescribed in the hemodialysis population, the safety and efficacy of heparin in the presence of these medications is unclear. This retrospective cohort study considered adult hemodialysis patients treated in the United States (August 2015-July 2017). Read More

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http://dx.doi.org/10.1007/s40620-018-00576-wDOI Listing
June 2019
4 Reads

Effects of oral activated charcoal on hyperphosphatemia and vascular calcification in Chinese patients with stage 3-4 chronic kidney disease.

J Nephrol 2019 Apr 26;32(2):265-272. Epub 2018 Dec 26.

Department of Nephrology, Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.

Background: The relationship between oral activated charcoal (OAC) and hyperphosphatemia and vascular calcification is not completely clear. We observed and recorded the effects of OAC on hyperphosphatemia and vascular calcification in stage 3-4 chronic kidney disease (CKD).

Methods: In a randomized controlled study, we included 97 patients with stage 3-4 CKD. Read More

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http://link.springer.com/10.1007/s40620-018-00571-1
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http://dx.doi.org/10.1007/s40620-018-00571-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422957PMC
April 2019
14 Reads
1.996 Impact Factor

Transient and persistent acute kidney injury in acute liver failure.

J Nephrol 2019 Apr 19;32(2):289-296. Epub 2018 Dec 19.

Division of Nephrology and Renal Transplantation, Department of Medicina, Centro Hospitalar Lisboa Norte, EPE, Lisboa, Portugal.

Background: Acute Kidney Injury (AKI) is a very frequent complication in the Acute Liver Failure (ALF) population associated with negative outcomes. We aim to evaluate the impact of AKI duration on the outcomes of an ALF population.

Methods: A 20-year retrospective analysis of ALF patients admitted to an Intensive Care Unit (ICU) was performed. Read More

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http://dx.doi.org/10.1007/s40620-018-00568-wDOI Listing
April 2019
3 Reads

When kidneys and lungs suffer together.

J Nephrol 2018 Dec 6. Epub 2018 Dec 6.

University of Insubria, Varese, Italy.

A significant interaction between kidneys and lungs has been shown in physiological and pathological conditions. The two organs can both be targets of the same systemic disease (eg., some vasculitides). Read More

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http://dx.doi.org/10.1007/s40620-018-00563-1DOI Listing
December 2018
16 Reads
1.996 Impact Factor

Subclinical AKI: ready for primetime in clinical practice?

J Nephrol 2019 Feb 6;32(1):9-16. Epub 2018 Dec 6.

Renal Division, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.

There has been considerable progress over the last decade in the standardization of the acute kidney injury (AKI) definition with the publication of the RIFLE, AKIN, KDIGO and ERBP classification criteria. However, these classification criteria still rely on imperfect parameters such as serum creatinine and urinary output. The use of timed urine collections, kinetic eGFR (estimated glomerular filtration rate), real time measurement of GFR and direct measures of tubular damage can theoretically aid in a more timely diagnosis of AKI and improve patients' outcome. Read More

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http://dx.doi.org/10.1007/s40620-018-00566-yDOI Listing
February 2019
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Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury.

J Nephrol 2019 Apr 6;32(2):297-306. Epub 2018 Dec 6.

Acute and Chronic Renal Failure Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Background: The choice of the specific modality and treatment duration of renal replacement therapy (RRT) to adopt in metformin-associated lactic acidosis (MALA) is still debated. We aimed to verify if sustained low-efficiency dialysis (SLED) is a rational choice in patients with MALA and acute kidney injury (AKI).

Methods: We collected serial serum metformin measurements, clinical parameters, and outcome data in ten consecutive patients (mean age 77 years [range 58-88], 5 males) admitted to our renal intensive care unit for suspected MALA associated with AKI and hemodynamic instability. Read More

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http://dx.doi.org/10.1007/s40620-018-00562-2DOI Listing
April 2019
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Renal intraparenchymal resistive index: the ultrasonographic answer to many clinical questions.

J Nephrol 2018 Dec 11. Epub 2018 Dec 11.

Nephrology and Dialysis Unit, "S. Giovanni di Dio" Hospital, Agrigento, Italy.

The use of renal resistive indices (RRIs) for the study of renal microcirculation has in the past been proposed for the identification of renal organ damage or even to specifically identify injury to some areas of the renal parenchyma. Nevertheless, according to the most recent evidences from literature this organ-based conception of RRIs has been proven to be partial and unable to explain the RRIs variations in clinical settings of sepsis or combined organ failure of primitively extrarenal origin or, more generally, the deep connection between RRIs and hemodynamic factors such as compliance and pulsatility of the large vessels. The aim of this review is to explain the physiopathological basis of RRIs determination and the most common interpretative errors in their analysis. Read More

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http://link.springer.com/10.1007/s40620-018-00567-x
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http://dx.doi.org/10.1007/s40620-018-00567-xDOI Listing
December 2018
17 Reads

Glomerular isolated microscopic hematuria: urinary features and long term follow-up of a selected cohort of patients.

J Nephrol 2019 Apr 10;32(2):253-258. Epub 2018 Dec 10.

Clinical and Research Laboratory on Urinary Sediment, U.O.C. di Nefrologia, Dialisi e Trapianto di Rene, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda, 15, Milan, Italy.

Background: Isolated microscopic hematuria is a condition characterized by the presence in the urine of an "abnormal" number of erythrocytes in the absence of proteinuria. Several studies have been published on this condition, but with heterogeneous inclusion criteria and variable outcomes at follow-up. In this retrospective study, we describe a selected and homogenous cohort of patients who presented with isolated microscopic hematuria of glomerular origin. Read More

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http://link.springer.com/10.1007/s40620-018-0560-9
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http://dx.doi.org/10.1007/s40620-018-0560-9DOI Listing
April 2019
2 Reads

Aortic pulse wave velocity is greater in peritoneal dialysis patients with lower dual energy X-ray absorptiometry (DXA) femoral neck bone mineral density.

J Nephrol 2019 Jun 10;32(3):471-476. Epub 2018 Dec 10.

UCL Department of Nephrology, Royal Free hospital, University College London, Rowland Hill Street, London, NW3 2PF, UK.

Background: Increased vascular stiffness is associated with low bone mineral density (BMD) in the general population, and both are risk factors for mortality. We wished to determine whether vascular stiffness is associated with BMD in peritoneal dialysis (PD) patients.

Methods: We measured vascular stiffness by aortic pulse wave velocity (aPWV), BMD by dual electron absorptiometry (DXA) scanning, and body composition using bioimpedance. Read More

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http://dx.doi.org/10.1007/s40620-018-0551-xDOI Listing
June 2019
6 Reads

Expression of Concern: Emphysematous pyelonephritis due to Aspergillus fumigatus-a case report.

Authors:

J Nephrol 2018 12 5:161. Epub 2018 Dec 5.

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http://dx.doi.org/10.1007/s40620-018-0558-3DOI Listing
December 2018
2 Reads