2,757 results match your criteria Journal of Nephrology[Journal]


Renal response to an oral protein load in patients with central diabetes insipidus before and after treatment with vasopressin.

J Nephrol 2019 Feb 19. Epub 2019 Feb 19.

Division of Nephrology, Department of Scienze mediche traslazionali, Università della Campania "L. Vanvitelli", Padiglione 17, via Pansini 5, 80131, Naples, Italy.

Aim: Different factors have been hypothesized to play a role in the cascade of events associated with the protein-induced glomerular response. However, scant data are available on the possible functional effect of vasopressin (VP) on the glomerular filtration rate (GFR) in humans with central diabetes insipidus (CDI), which was the aim of the present study.

Method: Renal function was studied under fasting conditions (baseline) and after a meat meal in 16 patients with CDI before and after treatment with desmopressin (DDAVP) and in 16 control subjects. Read More

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http://dx.doi.org/10.1007/s40620-018-00575-xDOI Listing
February 2019

A cardiac magnetic resonance imaging study of long-term and incident hemodialysis patients.

J Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.

Background: The cardiovascular morphology and function in long-term survivors of hemodialysis are not well described.

Methods: Single-center cross-sectional study nested within a prospective cohort study of 15 long-term (> 7.5 years) and 15 matched incident (< 6 months) hemodialysis patients with 15 external matched controls. Read More

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http://dx.doi.org/10.1007/s40620-019-00593-3DOI Listing
February 2019

Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus.

J Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory Medicine Unit, Department of Medicine, University of Padova, Padua, Italy.

Background And Aims: Diabetes mellitus is recognized as one of the major causes of end stage kidney disease. Bone Gla protein (BGP) is a vitamin K-dependent protein involved in bone mineralization and vascular calcifications (VC). Our goal was to characterize BGP and undercarboxylated BGP (ucBGP) in DM patients on HD, compared to HD patients without DM, and their association with vascular and bone disease. Read More

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http://dx.doi.org/10.1007/s40620-019-00595-1DOI Listing
February 2019
1 Read

Burden, access, and disparities in kidney disease.

J Nephrol 2019 Feb;32(1):1-8

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1007/s40620-019-00590-6DOI Listing
February 2019

C-reactive protein velocity and the risk of acute kidney injury among ST elevation myocardial infarction patients undergoing primary percutaneous intervention.

J Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman St, Tel Aviv, 64239, Israel.

Background: Elevated C-reactive protein (CRP) was shown to be associated with an increased risk for acute kidney injury (AKI) in ST elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI), however, the optimal time frame to measure CRP for risk stratification is not known. We evaluated the relation between the change in CRP over time (CRP velocity-CRPv) and AKI among STEMI patients treated with primary PCI.

Methods: We included 801 STEMI who presented between 2007 and 2017 and had their CRP measured with a wide range assay (wr-CRP) at least twice during the 24 h after admission. Read More

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http://dx.doi.org/10.1007/s40620-019-00594-2DOI Listing
January 2019

Recurrent urinary tract infections in kidney transplant recipients during the first-year influence long-term graft function: a single-center retrospective cohort study.

J Nephrol 2019 Jan 30. Epub 2019 Jan 30.

Department of Emergency and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy.

Urinary tract infections (UTIs) after kidney transplantation are associated with significant morbidity. However, data on the impact of UTI on graft survival are controversial. We conducted a retrospective cohort study of 380 kidney transplant patients. Read More

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http://dx.doi.org/10.1007/s40620-019-00591-5DOI Listing
January 2019
1 Read

Anticoagulation in CKD and ESRD.

J Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Medicine, University of Calgary, Calgary, AB, Canada.

In this review we discuss the evolving literature of anticoagulation in the context of the nephrology patient. Whereas CKD patients with atrial fibrillation, should be anticoagulated, the benefit of anticoagulation for those on dialysis remains controversial due to an increased risk of bleeding. The availability of direct oral anticoagulants offers new options for those with CKD. Read More

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http://dx.doi.org/10.1007/s40620-019-00592-4DOI Listing
January 2019

Updates on urinary tract infections in kidney transplantation.

J Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, 'Aldo Moro' University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy.

Urinary tract infection (UTI) represents the most common infection after kidney transplantation; it is associated with an increased risk for acute kidney rejection and impaired graft function in the early post-transplant period. Kidney transplant recipients with UTIs are often clinically asymptomatic due to the immunosuppressive therapy; however, asymptomatic bacteriuria may progress to acute pyelonephritis, bacteremia and urosepsis, particularly in the early post-transplant period, that are independent risk factors for short and long-term graft and patient survival. This article reviews the definitions, incidence, risk factors and the management of UTI in kidney transplant recipients; furthermore, the main controversial and still unanswered questions, regarding the causes of recurrent UTIs, adequate use of antibiotics to avoid antibiotic resistance, dosing and timing for prophylaxis and treatment of symptomatic infections, are also discussed. Read More

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http://dx.doi.org/10.1007/s40620-019-00585-3DOI Listing
January 2019
15 Reads

Meeting report of the "Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017".

J Nephrol 2019 Jan 24. Epub 2019 Jan 24.

Department of Internal Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, genetics, pathological, as well as clinical and research topics. The participants included clinicians and recognized experts in the field from Europe and the United States interacted closely during the symposium which promoted a chance to explore new frontiers in the field of kidney stone disease. Read More

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http://dx.doi.org/10.1007/s40620-019-00587-1DOI Listing
January 2019
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The role of the intestinal microbiota in uremic solute accumulation: a focus on sulfur compounds.

J Nephrol 2019 Jan 23. Epub 2019 Jan 23.

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", Via Luigi de Crecchio 7, 80138, Naples, Italy.

The gut microbiota is considered to be a novel important factor to take into account in the pathogenesis of chronic kidney disease and uremia. Much attention has been paid to specific uremic retention solutes of microbial origin, such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide. However, other novel less well studied compounds, such as hydrogen sulfide and related sulfur metabolites (sulfane sulfur, lanthionine, etc. Read More

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http://dx.doi.org/10.1007/s40620-019-00589-zDOI Listing
January 2019
2 Reads

Generalizability of SPRINT-CKD cohort to CKD patients referred to renal clinics.

J Nephrol 2019 Jan 23. Epub 2019 Jan 23.

Division of Nephrology, Department of Scienze Mediche e Chirurgiche Avanzate, University of Campania "Luigi Vanvitelli", Via M. Longo 50, 80138, Naples, Italy.

Background: The Systolic Blood Pressure Intervention Trial-CKD substudy (SPRINT-CKD) has suggested a lower blood pressure (BP) target in CKD patients. However, it is questionable whether the SPRINT-CKD results may be generalized to CKD patients under nephrology care.

Methods: To compare SPRINT-CKD cohort versus referred CKD patients in terms of patients' risk profile and outcomes, we pooled four prospective cohorts of consecutive CKD patients referred to 40 Italian renal clinics. Read More

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http://dx.doi.org/10.1007/s40620-019-00588-0DOI Listing
January 2019

Cyclooxygenase 2 inhibition slows disease progression and improves the altered renal lipid mediator profile in the Pkd2 mouse model of autosomal dominant polycystic kidney disease.

J Nephrol 2019 Jan 22. Epub 2019 Jan 22.

Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada.

Background: Increased levels of cyclooxygenase (COX) derived oxylipins is the earliest and most consistent alteration in the renal oxylipin profile in diverse models of cystic kidney diseases. Therefore, we examined whether a COX2 inhibitor would reduce disease progression in the Pkd2 mouse model of autosomal dominant polycystic kidney disease (ADPKD).

Methods: Weanling normal and diseased male Pkd2 mice were provided diets that provided 0 or 50 mg celecoxib/kg body weight/day, for 13 weeks. Read More

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http://dx.doi.org/10.1007/s40620-018-00578-8DOI Listing
January 2019
1 Read

Improving the appropriateness of depression treatment in patients with advanced chronic kidney disease.

J Nephrol 2019 Jan 22. Epub 2019 Jan 22.

Laboratory «Movement, Interactions, Performance» (E.A. 4334), University of Nantes, 25 Bis Boulevard Guy Mollet, BP 72206, 44322, Nantes Cedex 3, France.

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http://dx.doi.org/10.1007/s40620-018-00564-0DOI Listing
January 2019

Hemodialysis access type is associated with blood pressure variability and echocardiographic changes in end-stage renal disease patients.

J Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Department of Nephrology, West China Hospital, Sichuan University, Guoxue Alley No.37, Chengdu, 610041, Sichuan Province, China.

Arteriovenous fistula (AVF) strategy has been recommended in clinical guidelines for a long time due to the survival benefits associated with it. However, the underlying mechanism still needs to be explored. This retrospective cohort study included 611 patients who received hemodialysis in West China Hospital Medical Center between January 1, 2014 and December 31, 2014. Read More

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http://link.springer.com/10.1007/s40620-018-00574-y
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http://dx.doi.org/10.1007/s40620-018-00574-yDOI Listing
January 2019
6 Reads

Beyond chronic kidney disease: the diagnosis of Renal Disease in the Elderly as an unmet need. A position paper endorsed by Italian Society of Nephrology (SIN) and Italian Society of Geriatrics and Gerontology (SIGG).

J Nephrol 2019 Jan 18. Epub 2019 Jan 18.

Unit of Geriatrics, Campus Bio-Medico University, Rome, Italy.

The dramatic increase in prevalence of chronic kidney disease (CKD) with ageing makes the recognition and correct referral of these patients of paramount relevance in order to implement interventions preventing or delaying the development of CKD complications and end-stage renal disease. Nevertheless, several issues make the diagnosis of CKD in the elderly cumbersome. Among these are age related changes in structures and functions of the kidney, which may be difficult to distinguish from CKD, and multimorbidity. Read More

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http://dx.doi.org/10.1007/s40620-019-00584-4DOI Listing
January 2019
2 Reads

Effects of intradialytic aerobic exercise on hemodialysis patients: a systematic review and meta-analysis.

J Nephrol 2019 Jan 18. Epub 2019 Jan 18.

School of Public Health and Primary Care, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Objective: Intradialytic exercise (IDE) is not yet a routine practice for hemodialysis patients, the lack of guidelines supporting it being a major reason. This systematic review and meta-analysis of aerobic IDE interventions examined the efficacy of IDE regarding quality of life (QOL), serum phosphorus, dialysis efficiency, inflammatory status, vitamin D3, parathyroid hormone, intake of phosphate binders, mortality and hospitalization rate.

Methods: Pubmed, Medline (Ovid), Embase (Ovid), Cochrane, and Cinahl (EBSCO) databases were searched to retrieve studies up to June 12, 2018. Read More

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http://dx.doi.org/10.1007/s40620-018-00565-zDOI Listing
January 2019
1 Read

The PIRP project (Prevenzione Insufficienza Renale Progressiva): how to integrate hospital and community maintenance treatment for chronic kidney disease.

J Nephrol 2019 Jan 18. Epub 2019 Jan 18.

Nephrology and Dialysis Unit, Ospedale S. Maria della Scaletta, Imola, Italy.

Chronic kidney disease (CKD) represents a global health burden with great economic impact on healthcare and therefore it requires appropriate interventions by Health Care Systems. The PIRP (Prevenzione Insufficienza Renale Progressiva) project is endorsed and funded by the Emilia-Romagna Regional Health Board and involves all the Nephrology Units of the Emilia-Romagna Region (Italy). The project has a predominantly clinical purpose and is expected to bring about a continuous quality improvement in the treatment of patients with CKD. Read More

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http://link.springer.com/10.1007/s40620-018-00570-2
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http://dx.doi.org/10.1007/s40620-018-00570-2DOI Listing
January 2019
5 Reads

Exercise training in kidney transplant recipients: a systematic review.

J Nephrol 2019 Jan 16. Epub 2019 Jan 16.

Division of Nephrology, Dialysis and Transplantation, Nephrology Unit, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.

Background And Aims: Evidences on the benefits of physical exercise in kidney transplant patients (KTx) are not conclusive and concerns on safety remain. We here gather and interpret current evidence on the benefits/harms of exercise training intervention in KTx.

Methods: Systematic review of exercise training programs in KTx. Read More

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http://dx.doi.org/10.1007/s40620-019-00583-5DOI Listing
January 2019
2 Reads

Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic.

J Nephrol 2019 Jan 11. Epub 2019 Jan 11.

Department of Surgery, Austin Health, The University of Melbourne, Studley Rd., Heidelberg, VIC, 3084, Australia.

Acute kidney injury (AKI) as a result of ischaemia-reperfusion represents a major healthcare burden worldwide. Mortality rates from AKI in hospitalized patients are extremely high and have changed little despite decades of research and medical advances. In 1986, Murry et al. Read More

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http://dx.doi.org/10.1007/s40620-019-00582-6DOI Listing
January 2019

Sodium removal and plasma tonicity balance are not different in hemodialysis and hemodiafiltration using high-flux membranes.

J Nephrol 2019 Jan 10. Epub 2019 Jan 10.

Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy.

Background: The clinical benefits of on-line hemodiafiltration (HDF) versus high-flux membranes hemodialysis (hf-HD) are still debated. In fact, although a superiority of one treatment over the other, especially in terms of mortality, did not emerge from the analysis of clinical trials, improved intradialytic vascular stability and cardiovascular mortality have been observed in patients undergoing HDF rather than hf-HD; the lower removal of sodium (Na) during HDF seems to play a major role. The plasma concentration of Na is the major determinant of plasma tonicity, which, by determining the flow of water between the intracellular and the extracellular compartment, contributes to the vascular refilling process and the maintenance of blood pressure during the hemodialysis treatment. Read More

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http://dx.doi.org/10.1007/s40620-018-00581-zDOI Listing
January 2019

Novel markers of graft outcome in a cohort of kidney transplanted patients: a cohort observational study.

J Nephrol 2019 Feb 10;32(1):139-150. Epub 2019 Jan 10.

Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione Istituto di Ricerca e Cura a Carattere Scientifico Cà Granda Ospedale Maggiore Policlinico, Via Commenda 15, 20122, Milan, Italy.

Renal biopsy (RBx) informs about kidney transplantation (KTx) prognosis. In our observational study the prevalence of histological anomalies and the prognostic role of CD45, vimentin (VIM) and periostin (POSTN) in KTx-RBx have been evaluated. One hundred forty-six KTx-RBx (2009-2012) were analysed for general histology and in immunohistochemistry for CD45, VIM and POSTN. Read More

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http://dx.doi.org/10.1007/s40620-018-00580-0DOI Listing
February 2019

Transplant waitlisting attenuates the association between hemodialysis access type and mortality.

J Nephrol 2019 Jan 2. Epub 2019 Jan 2.

University of California San Diego, San Diego, CA, USA.

Prior studies have shown that beginning hemodialysis (HD) with a hemodialysis catheter (HC) is associated with worse mortality than with an arteriovenous fistula (AVF) or arteriovenous graft (AVG). We hypothesized that transplant waitlisting would modify the effect of HD access on mortality, given waitlist candidates' more robust health status. Using the US Renal Data System, we studied patients with incident ESRD who initiated HD between 2010 and 2015 with an AVF, AVG, or HC. Read More

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http://dx.doi.org/10.1007/s40620-018-00572-0DOI Listing
January 2019
5 Reads

How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network.

J Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Pathology Unit, S. Orsola-Malpighi University Hospital of Bologna, Bologna, Italy.

Guidelines for donor selection have changed to expand the donor pool, considering potential donors affected by a neoplasm. Aim of this retrospective study is to look at the use of organs from donors with a current or history of neoplasm within the Italian Transplant Network. Data, collected and validated by Italian National Health Institute for the time interval 2006-2015, have been reviewed retrospectively by mean of multivariable pivot tables. Read More

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http://dx.doi.org/10.1007/s40620-018-00573-zDOI Listing
January 2019

Incremental dialysis in ESRD: systematic review and meta-analysis.

J Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Division of Nephrology, Department of Scienze Mediche e Chirurgiche Avanzate, University of Campania "Luigi Vanvitelli", Via M. Longo 50, 80138, Naples, Italy.

Background: Incremental dialysis may preserve residual renal function and improve survival in comparison with full-dose dialysis; however, available evidence is limited. We therefore compared all-cause mortality and residual kidney function (RKF) loss in incremental and full-dose dialysis and time to full-dose dialysis in incremental hemodialysis (IHD) and incremental peritoneal dialysis (IPD).

Methods: We performed a systematic review and meta-analysis of cohort studies of adults with ESRD starting IHD and IPD. Read More

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http://link.springer.com/10.1007/s40620-018-00577-9
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http://dx.doi.org/10.1007/s40620-018-00577-9DOI Listing
January 2019
2 Reads

Fertility and reproductive care in chronic kidney disease.

J Nephrol 2019 Feb 2;32(1):39-50. Epub 2019 Jan 2.

Department of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.

In both women and men, chronic kidney disease (CKD) is associated with decreased fertility. Though a multitude of factors contribute to the reduction in fertility in this population, progressively impaired function of the hypothalamic-pituitary-gonadal axis appears to play a key role in the pathophysiology. There is limited research on strategies to manage infertility in the CKD population, but intensive hemodialysis, kidney transplantation, medication management and assisted reproductive technologies (ART) have all been proposed. Read More

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http://link.springer.com/10.1007/s40620-018-00569-9
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http://dx.doi.org/10.1007/s40620-018-00569-9DOI Listing
February 2019
3 Reads

Safety and efficacy of heparin during dialysis in the context of systemic anticoagulant and antiplatelet medications.

J Nephrol 2019 Jan 2. Epub 2019 Jan 2.

DaVita Kidney Care, Denver, CO, USA.

Heparin is widely used to prevent coagulation during hemodialysis. Although systemic anticoagulants and antiplatelet agents are commonly prescribed in the hemodialysis population, the safety and efficacy of heparin in the presence of these medications is unclear. This retrospective cohort study considered adult hemodialysis patients treated in the United States (August 2015-July 2017). Read More

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http://dx.doi.org/10.1007/s40620-018-00576-wDOI Listing
January 2019
1 Read

Effects of oral activated charcoal on hyperphosphatemia and vascular calcification in Chinese patients with stage 3-4 chronic kidney disease.

J Nephrol 2018 Dec 26. Epub 2018 Dec 26.

Department of Nephrology, Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.

Background: The relationship between oral activated charcoal (OAC) and hyperphosphatemia and vascular calcification is not completely clear. We observed and recorded the effects of OAC on hyperphosphatemia and vascular calcification in stage 3-4 chronic kidney disease (CKD).

Methods: In a randomized controlled study, we included 97 patients with stage 3-4 CKD. Read More

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http://link.springer.com/10.1007/s40620-018-00571-1
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http://dx.doi.org/10.1007/s40620-018-00571-1DOI Listing
December 2018
8 Reads
1.996 Impact Factor

Transient and persistent acute kidney injury in acute liver failure.

J Nephrol 2018 Dec 19. Epub 2018 Dec 19.

Division of Nephrology and Renal Transplantation, Department of Medicina, Centro Hospitalar Lisboa Norte, EPE, Lisboa, Portugal.

Background: Acute Kidney Injury (AKI) is a very frequent complication in the Acute Liver Failure (ALF) population associated with negative outcomes. We aim to evaluate the impact of AKI duration on the outcomes of an ALF population.

Methods: A 20-year retrospective analysis of ALF patients admitted to an Intensive Care Unit (ICU) was performed. Read More

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http://dx.doi.org/10.1007/s40620-018-00568-wDOI Listing
December 2018
1 Read

When kidneys and lungs suffer together.

J Nephrol 2018 Dec 6. Epub 2018 Dec 6.

University of Insubria, Varese, Italy.

A significant interaction between kidneys and lungs has been shown in physiological and pathological conditions. The two organs can both be targets of the same systemic disease (eg., some vasculitides). Read More

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http://dx.doi.org/10.1007/s40620-018-00563-1DOI Listing
December 2018
10 Reads
1.996 Impact Factor

Subclinical AKI: ready for primetime in clinical practice?

J Nephrol 2019 Feb 6;32(1):9-16. Epub 2018 Dec 6.

Renal Division, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.

There has been considerable progress over the last decade in the standardization of the acute kidney injury (AKI) definition with the publication of the RIFLE, AKIN, KDIGO and ERBP classification criteria. However, these classification criteria still rely on imperfect parameters such as serum creatinine and urinary output. The use of timed urine collections, kinetic eGFR (estimated glomerular filtration rate), real time measurement of GFR and direct measures of tubular damage can theoretically aid in a more timely diagnosis of AKI and improve patients' outcome. Read More

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http://dx.doi.org/10.1007/s40620-018-00566-yDOI Listing
February 2019
1 Read

Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury.

J Nephrol 2018 Dec 6. Epub 2018 Dec 6.

Acute and Chronic Renal Failure Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Background: The choice of the specific modality and treatment duration of renal replacement therapy (RRT) to adopt in metformin-associated lactic acidosis (MALA) is still debated. We aimed to verify if sustained low-efficiency dialysis (SLED) is a rational choice in patients with MALA and acute kidney injury (AKI).

Methods: We collected serial serum metformin measurements, clinical parameters, and outcome data in ten consecutive patients (mean age 77 years [range 58-88], 5 males) admitted to our renal intensive care unit for suspected MALA associated with AKI and hemodynamic instability. Read More

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http://dx.doi.org/10.1007/s40620-018-00562-2DOI Listing
December 2018
2 Reads

Renal intraparenchymal resistive index: the ultrasonographic answer to many clinical questions.

J Nephrol 2018 Dec 11. Epub 2018 Dec 11.

Nephrology and Dialysis Unit, "S. Giovanni di Dio" Hospital, Agrigento, Italy.

The use of renal resistive indices (RRIs) for the study of renal microcirculation has in the past been proposed for the identification of renal organ damage or even to specifically identify injury to some areas of the renal parenchyma. Nevertheless, according to the most recent evidences from literature this organ-based conception of RRIs has been proven to be partial and unable to explain the RRIs variations in clinical settings of sepsis or combined organ failure of primitively extrarenal origin or, more generally, the deep connection between RRIs and hemodynamic factors such as compliance and pulsatility of the large vessels. The aim of this review is to explain the physiopathological basis of RRIs determination and the most common interpretative errors in their analysis. Read More

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http://link.springer.com/10.1007/s40620-018-00567-x
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http://dx.doi.org/10.1007/s40620-018-00567-xDOI Listing
December 2018
11 Reads

Glomerular isolated microscopic hematuria: urinary features and long term follow-up of a selected cohort of patients.

J Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Clinical and Research Laboratory on Urinary Sediment, U.O.C. di Nefrologia, Dialisi e Trapianto di Rene, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda, 15, Milan, Italy.

Background: Isolated microscopic hematuria is a condition characterized by the presence in the urine of an "abnormal" number of erythrocytes in the absence of proteinuria. Several studies have been published on this condition, but with heterogeneous inclusion criteria and variable outcomes at follow-up. In this retrospective study, we describe a selected and homogenous cohort of patients who presented with isolated microscopic hematuria of glomerular origin. Read More

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http://link.springer.com/10.1007/s40620-018-0560-9
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http://dx.doi.org/10.1007/s40620-018-0560-9DOI Listing
December 2018
1 Read

Aortic pulse wave velocity is greater in peritoneal dialysis patients with lower dual energy X-ray absorptiometry (DXA) femoral neck bone mineral density.

J Nephrol 2018 Dec 10. Epub 2018 Dec 10.

UCL Department of Nephrology, Royal Free hospital, University College London, Rowland Hill Street, London, NW3 2PF, UK.

Background: Increased vascular stiffness is associated with low bone mineral density (BMD) in the general population, and both are risk factors for mortality. We wished to determine whether vascular stiffness is associated with BMD in peritoneal dialysis (PD) patients.

Methods: We measured vascular stiffness by aortic pulse wave velocity (aPWV), BMD by dual electron absorptiometry (DXA) scanning, and body composition using bioimpedance. Read More

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http://dx.doi.org/10.1007/s40620-018-0551-xDOI Listing
December 2018

Expression of Concern: Emphysematous pyelonephritis due to Aspergillus fumigatus-a case report.

Authors:

J Nephrol 2018 12 5:161. Epub 2018 Dec 5.

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http://dx.doi.org/10.1007/s40620-018-0558-3DOI Listing
December 2018
1 Read

Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease.

J Nephrol 2019 Feb 29;32(1):111-119. Epub 2018 Nov 29.

School of Health and Social Studies, Dalarna University, Falun, Sweden.

Introduction: Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular disease mechanisms. Plasma levels of 92 cardiovascular disease-associated proteins were assessed by proximity extension assay (Proseek Multiplex CVD-1, Olink Bioscience, Uppsala, Sweden) in a discovery cohort of dialysis patients, the Mapping of Inflammatory Markers in Chronic Kidney disease cohort [MIMICK; n = 183, 55% women, mean age 63 years, 46 cardiovascular deaths during follow-up (mean 43 months)]. Significant results were replicated in the incident and prevalent hemodialysis arm of the Salford Kidney Study [SKS dialysis study, n = 186, 73% women, mean age 62 years, 45 cardiovascular deaths during follow-up (mean 12 months)], and in the CKD5-LD-RTxcohort with assessments of coronary artery calcium (CAC)-score by cardiac computed tomography (n = 89, 37% women, mean age 46 years). Read More

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http://dx.doi.org/10.1007/s40620-018-0556-5DOI Listing
February 2019
8 Reads

Natural history and risk factors for diabetic kidney disease in patients with T2D: lessons from the AMD-annals.

J Nephrol 2018 Nov 27. Epub 2018 Nov 27.

Università degli Studi and IRCCS Policlinico San Martino-IST, Genoa, Italy.

The Associazione Medici Diabetologi (AMD) annals initiative is an ongoing observational survey promoted by AMD. It is based on a public network of about 700 Italian diabetes clinics, run by specialists who provide diagnostic confirmation and prevention and treatment of diabetes and its complications. Over the last few years, analysis of the AMD annals dataset has contributed several important insights on the clinical features of type-2 diabetes kidney disease and their prognostic and therapeutic implications. Read More

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http://dx.doi.org/10.1007/s40620-018-00561-3DOI Listing
November 2018
9 Reads

Twin pregnancy in a patient on chronic haemodialysis who already had three pregnancies.

J Nephrol 2018 Nov 26. Epub 2018 Nov 26.

Department of Nephrology, Dialysis and Hypertension, Edouard Herriot Hospital, Hospices Civils de Lyon, 5 place d'Arsonval, 69003, Lyon, France.

Pregnancy in women with end-stage renal disease is rare. Multiple pregnancies carry a high risk of complications even in healthy individuals. We report the case of a 36-year-old woman who had four pregnancies while she was on dialysis, including one twin pregnancy. Read More

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http://link.springer.com/10.1007/s40620-018-0555-6
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http://dx.doi.org/10.1007/s40620-018-0555-6DOI Listing
November 2018
8 Reads

Control of metabolic predisposition to cardiovascular complications of chronic kidney disease by effervescent calcium magnesium citrate: a feasibility study.

J Nephrol 2019 Feb 21;32(1):93-100. Epub 2018 Nov 21.

Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Aims: Cardiovascular (CV) complications are common in chronic kidney disease (CKD). Numerous metabolic disturbances including hyperphosphatemia, high circulating calciprotein particles (CPP), hyperparathyroidism, metabolic acidosis, and magnesium deficiency are associated with, and likely pathogenic for CV complications in CKD. The goal of this feasibility study was to determine whether effervescent calcium magnesium citrate (EffCaMgCit) ameliorates the aforementioned pathogenic intermediates. Read More

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http://dx.doi.org/10.1007/s40620-018-0559-2DOI Listing
February 2019
9 Reads

Fibroblast growth factor-23 correlates with advanced disease conditions and predicts high risk of major adverse cardiac and cerebral events in end-stage renal disease patients undergoing continuous ambulatory peritoneal dialysis.

J Nephrol 2018 Nov 21. Epub 2018 Nov 21.

Department of Nephrology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Street, Wuhan, 430000, China.

Background: This study aimed to investigate the correlation of serum fibroblast growth factor-23 (FGF-23) level with clinical indexes, in particular to explore the value of FGF-23 in predicting major adverse cardiac and cerebral event (MACCE) risk in end-stage renal disease (ESRD) patients undergoing continuous ambulatory peritoneal dialysis (CAPD).

Methods: In 270 ESRD patients undergoing CAPD consecutively enrolled in this prospective cohort study, we collected serum samples and performed enzyme-linked immunosorbent assay to detect FGF-23 expression. MACCE-free survival was defined as the date from enrollment to the date of MACCE occurrence. Read More

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http://dx.doi.org/10.1007/s40620-018-0557-4DOI Listing
November 2018
1 Read

Effects of late cyclosporine withdrawal on renal graft function and survival.

J Nephrol 2018 Nov 15. Epub 2018 Nov 15.

Medical Department I, University Hospital Marien Hospital Herne, Ruhr University Bochum, Hölkeskampring 40, 44625, Herne, Germany.

Objective: Attempts to discontinue calcineurin inhibitors (CNIs) early after renal transplantation without conversion to an alternative immunosuppressive have failed due to high rates of acute rejection. Data on "late" CNI withdrawal are lacking so far.

Design And Method: We carried out a matched case-control study on the effects of CNI withdrawal on graft loss and mortality in 90 patients (1500 screened) with advanced graft dysfunction (serum creatinine > 3. Read More

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http://link.springer.com/10.1007/s40620-018-0554-7
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http://dx.doi.org/10.1007/s40620-018-0554-7DOI Listing
November 2018
8 Reads

Pregnancy in women with diabetic nephropathy.

Authors:
Donatella Spotti

J Nephrol 2018 Nov 15. Epub 2018 Nov 15.

OU Nephrology and Dialysis, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.

The number of pregnancies in women with pregestational diabetes has been steadily increasing worldwide. These pregnancies are associated with an increased risk of a variety of complications, including miscarriages, congenital malformations, macrosomia, fetal growth restriction, preeclampsia, preterm delivery and stillbirth. In pregnant women with diabetic nephropathy it is important to evaluate both the effect of pregnancy on kidney function and the effect of kidney disease on pregnancy outcomes. Read More

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http://link.springer.com/10.1007/s40620-018-0553-8
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http://dx.doi.org/10.1007/s40620-018-0553-8DOI Listing
November 2018
8 Reads

Fibroblast growth factor 21 in chronic kidney disease.

J Nephrol 2018 Nov 14. Epub 2018 Nov 14.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Fibroblast growth factor 21 (FGF21) is a member of the endocrine FGF family that acts as a metabolic regulator of both glucose and lipid metabolism. Similar to fibroblast growth factor 23 (FGF23), serum FGF21 levels rise progressively with the loss of renal function, reaching 20 times normal values in end-stage renal disease. In patients with chronic kidney disease (CKD), higher serum FGF21 levels correlate with poorer metabolic profile, higher inflammatory markers, more comorbidities, and higher mortality. Read More

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http://link.springer.com/10.1007/s40620-018-0550-y
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http://dx.doi.org/10.1007/s40620-018-0550-yDOI Listing
November 2018
19 Reads

Recurrent venous thromboembolism in primary membranous nephropathy despite direct Xa inhibitor therapy.

J Nephrol 2018 Nov 12. Epub 2018 Nov 12.

Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Clinically apparent venous thromboembolism (VTE) occurs in approximately 7% of patients with membranous nephropathy. Hypoalbuminemia at diagnosis is an independent risk factor for VTE, and risk increases significantly as albumin falls. Optimal prophylactic and treatment anticoagulation regimens in the nephrotic syndrome remain unproven but novel oral anti-coagulants have become attractive therapeutic options. Read More

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http://link.springer.com/10.1007/s40620-018-0552-9
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http://dx.doi.org/10.1007/s40620-018-0552-9DOI Listing
November 2018
16 Reads

Cardiovascular risk in renal transplant recipients.

J Nephrol 2018 Nov 7. Epub 2018 Nov 7.

Regional Nephrology and Transplant Unit, Belfast City Hospital Northern Ireland, Belfast, BT9 7AB, UK.

Successful kidney transplantation offers patients with end-stage renal disease the greatest likelihood of survival. However, cardiovascular disease poses a major threat to both graft and patient survival in this cohort. Transplant recipients are unique in their accumulation of a wide range of traditional and non-traditional cardiovascular risk factors. Read More

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http://dx.doi.org/10.1007/s40620-018-0549-4DOI Listing
November 2018
9 Reads

Infusion of autologous bone marrow derived mononuclear stem cells potentially reduces urinary markers in diabetic nephropathy.

J Nephrol 2019 Feb 7;32(1):65-73. Epub 2018 Nov 7.

Department of Internal Medicine, JSC National Scientific Medical Research Center, Avenue Abylai-Khan #42, Astana, Kazakhstan, 010009.

Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Previous studies demonstrated safety and efficacy of autologous bone marrow-derived mononuclear cells (ABM-MNCs) in induced type-1 diabetes mellitus (T1DM) rats. However, the effect of ABM-MNCs on urinary markers of DN in humans is not well studied. Read More

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http://link.springer.com/10.1007/s40620-018-0548-5
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http://dx.doi.org/10.1007/s40620-018-0548-5DOI Listing
February 2019
11 Reads
1.996 Impact Factor

Tuberous sclerosis complex: new insights into clinical and therapeutic approach.

J Nephrol 2018 Nov 7. Epub 2018 Nov 7.

Laboratory of Experimental Nephrology, Renal Division, Dipartimento di Scienze della Salute, San Paolo Hospital, Università di Milano, Via A. di Rudinì, 8, 20142, Milan, Italy.

Tuberous sclerosis complex (TSC) is a complex disease with many different clinical manifestations. Despite the common opinion that TSC is a rare condition, with a mean incidence of 1/6000 live births and a prevalence of 1/20,000, it is increasingly evident that in reality this is not true. Its clinical sequelae span a range of multiple organ systems, in particular the central nervous system, kidneys, skin and lungs. Read More

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http://link.springer.com/10.1007/s40620-018-0547-6
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http://dx.doi.org/10.1007/s40620-018-0547-6DOI Listing
November 2018
9 Reads

The effect of polymorphism of uric acid transporters on uric acid transport.

J Nephrol 2018 Oct 31. Epub 2018 Oct 31.

Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum uric acid. Read More

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http://link.springer.com/10.1007/s40620-018-0546-7
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http://dx.doi.org/10.1007/s40620-018-0546-7DOI Listing
October 2018
4 Reads
2.000 Impact Factor

Tolvaptan in Japanese patients with later-stage autosomal dominant polycystic kidney disease.

J Nephrol 2018 Dec 24;31(6):961-966. Epub 2018 Oct 24.

Nephrology Center, Toranomon Hospital Kajigaya, 1-3-1 Kajigaya Takatsu-ku, Kawasaki, Kanagawa Prefecture, Japan.

Background: A recent study demonstrated that tolvaptan slowed estimated glomerular filtration rate (eGFR) decline in later-stage autosomal dominant polycystic kidney disease (ADPKD) patients. However, Japanese patients were not included in that trial, therefore tolvaptan's efficacy in Japanese patients with advanced chronic kidney disease (CKD) has remained unknown.

Methods: In this prospective cohort study, 54 patients with ADPKD who had eGFR ≥ 15 ml/min/1. Read More

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http://link.springer.com/10.1007/s40620-018-0545-8
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http://dx.doi.org/10.1007/s40620-018-0545-8DOI Listing
December 2018
2 Reads

High-sensitive cardiac troponin T: a biomarker of left-ventricular diastolic dysfunction in hemodialysis patients.

J Nephrol 2018 Dec 22;31(6):967-973. Epub 2018 Oct 22.

Department of Nephrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.

Objective: To identify the relationship between serum high-sensitive cardiac troponin T (hs-cTnT) and left ventricular diastolic dysfunction (LVDD) among maintenance hemodialysis patients and to further explore the value of hs-cTnT in evaluating and predicting LVDD in this special group of patients.

Methods: In a cross-sectional study, 152 dialysis patients with end-stage renal disease (ESRD) underwent Hs-cTnT measurement using the high sensitivity assay. Echocardiography measurements were carried out according to the American Society of Echocardiography recommendations and E/E' > 15 or E' < 7 cm/s was defined as diastolic dysfunction. Read More

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http://link.springer.com/10.1007/s40620-018-0540-0
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http://dx.doi.org/10.1007/s40620-018-0540-0DOI Listing
December 2018
4 Reads