723 results match your criteria Journal of Nanobiotechnology [Journal]


Correction to: Binding mechanism of anti-cancer chemotherapeutic drug mitoxantrone to DNA characterized by magnetic tweezers.

J Nanobiotechnology 2019 Feb 8;17(1):28. Epub 2019 Feb 8.

Experimental Biophysics and Applied Nanoscience, Physics Department, Bielefeld Institute for Nanoscience (BINAS), Bielefeld University, Universitaetsstrasse 25, 33615, Bielefeld, Germany.

Following publication of this article [1] we found a typographical error in the results reported in the abstract. The corrected sentences should read as below. Read More

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http://dx.doi.org/10.1186/s12951-018-0430-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367820PMC
February 2019

Real-time in vivo imaging of subpopulations of circulating tumor cells using antibody conjugated quantum dots.

J Nanobiotechnology 2019 Feb 6;17(1):26. Epub 2019 Feb 6.

Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.

Introduction: The detection of circulating tumor cells (CTCs) is very important for cancer diagnosis. CTCs can travel from primary tumors through the circulation to form secondary tumor colonies via bloodstream extravasation. The number of CTCs has been used as an indicator of cancer progress. Read More

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http://dx.doi.org/10.1186/s12951-019-0453-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364392PMC
February 2019

Long-term live cells observation of internalized fluorescent Fe@C nanoparticles in constant magnetic field.

J Nanobiotechnology 2019 Feb 6;17(1):27. Epub 2019 Feb 6.

Faculté de Médecine, Université François Rabelais, 37032, Tours, France.

Background: Theranostics application of superparamagnetic nanoparticles based on magnetite and maghemite is impeded by their toxicity. The use of additional protective shells significantly reduced the magnetic properties of the nanoparticles. Therefore, iron carbides and pure iron nanoparticles coated with multiple layers of onion-like carbon sheath seem to be optimal for biomedicine. Read More

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http://dx.doi.org/10.1186/s12951-019-0463-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364403PMC
February 2019
1 Read

Specific drug delivery efficiently induced human breast tumor regression using a lipoplex by non-covalent association with anti-tumor antibodies.

J Nanobiotechnology 2019 Feb 6;17(1):25. Epub 2019 Feb 6.

Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 30068, Taiwan, ROC.

Background: A cationic liposome-PEG-PEI complex (LPPC) was employed as a carrier for achieving targeted delivery of drug to human epidermal growth factor receptor-2 (HER2/neu)-expressing breast cancer cells. LPPC can be easily loaded with an anti-tumor drug and non-covalently associated with an anti-tumor antibody such as Herceptin that is clinically used to rapidly form immunoparticles within 1 h.

Results: Drug-loaded LPPC have an average size about 250 nm and a zeta potential of about 40 mV. Read More

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http://dx.doi.org/10.1186/s12951-019-0457-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364477PMC
February 2019
1 Read
4.078 Impact Factor

Two distinct cellular pathways leading to endothelial cell cytotoxicity by silica nanoparticle size.

J Nanobiotechnology 2019 Feb 5;17(1):24. Epub 2019 Feb 5.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

Background: Silica nanoparticles (SiNPs) are widely used for biosensing and diagnostics, and for the targeted delivery of therapeutic agents. Safety concerns about the biomedical and clinical applications of SiNPs have been raised, necessitating analysis of the effects of their intrinsic properties, such as sizes, shapes, and surface physicochemical characteristics, on human health to minimize risk in biomedical applications. In particular, SiNP size-associated toxicological effects, and the underlying molecular mechanisms in the vascular endothelium remain unclear. Read More

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http://dx.doi.org/10.1186/s12951-019-0456-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362579PMC
February 2019
1 Read

Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin.

J Nanobiotechnology 2019 Feb 2;17(1):22. Epub 2019 Feb 2.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222, Bialystok, Poland.

Background: Human plasma gelsolin (pGSN) is a multifunctional actin-binding protein involved in a variety of biological processes, including neutralization of pro-inflammatory molecules such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA) and modulation of host inflammatory response. It was found that PBP10, a synthetic rhodamine B-conjugated peptide, based on the phosphoinositide-binding site of pGSN, exerts bactericidal activity against Gram-positive and Gram-negative bacteria, interacts specifically with LPS and LTA, and limits microbial-induced inflammatory effects. The therapeutic efficiency of PBP10 when immobilized on the surface of iron oxide-based magnetic nanoparticles was not evaluated, to date. Read More

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http://dx.doi.org/10.1186/s12951-019-0455-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359803PMC
February 2019
2 Reads
4.078 Impact Factor

From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy.

J Nanobiotechnology 2019 Feb 2;17(1):23. Epub 2019 Feb 2.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing, 100190, China.

Background: In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application.

Results: Herein, we demonstrated self-assembled nanoparticles with single structure as a "from one to all" theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT). Read More

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http://dx.doi.org/10.1186/s12951-019-0450-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359812PMC
February 2019

Indoor nanoscale particulate matter-induced coagulation abnormality based on a human 3D microvascular model on a microfluidic chip.

J Nanobiotechnology 2019 Feb 1;17(1):20. Epub 2019 Feb 1.

Hubei Key Laboratory for Processing and Transformation of Agricultural Products (Wuhan Polytechnic University), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, 430023, People's Republic of China.

Background: A growing body of evidence shows that indoor concentrations of airborne particles are often higher than is typically encountered outdoors. Since exposure to indoor PM2.5 is thought to be associated with cardiovascular disease, the health impacts of indoor air pollution need to be explored. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0458-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357445PMC
February 2019

High time resolution and high signal-to-noise monitoring of the bacterial growth kinetics in the presence of plasmonic nanoparticles.

J Nanobiotechnology 2019 Feb 1;17(1):21. Epub 2019 Feb 1.

Bacterial Infections: Antimicrobial Therapies, Institute for Bioengineering of Catalonia (IBEC), The Institute of Science and Technology, Baldiri Reixac 15-21, 08028, Barcelona, Spain.

Background: Emerging concepts for designing innovative drugs (i.e., novel generations of antimicrobials) frequently include nanostructures, new materials, and nanoparticles (NPs). Read More

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http://dx.doi.org/10.1186/s12951-019-0459-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357367PMC
February 2019

Lecithin nano-liposomal particle as a CRISPR/Cas9 complex delivery system for treating type 2 diabetes.

J Nanobiotechnology 2019 Jan 29;17(1):19. Epub 2019 Jan 29.

College of Pharmacy, Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon, 16499, South Korea.

Background: Protein-based Cas9 in vivo gene editing therapeutics have practical limitations owing to their instability and low efficacy. To overcome these obstacles and improve stability, we designed a nanocarrier primarily consisting of lecithin that can efficiently target liver disease and encapsulate complexes of Cas9 with a single-stranded guide RNA (sgRNA) ribonucleoprotein (Cas9-RNP) through polymer fusion self-assembly.

Results: In this study, we optimized an sgRNA sequence specifically for dipeptidyl peptidase-4 gene (DPP-4) to modulate the function of glucagon-like peptide 1. Read More

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http://dx.doi.org/10.1186/s12951-019-0452-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350399PMC
January 2019

Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection.

J Nanobiotechnology 2019 Jan 25;17(1):15. Epub 2019 Jan 25.

Mycobacterial Genetics Unit, Institut Pasteur, Paris, France.

Background: Infectious diseases are still a leading cause of death and, with the emergence of drug resistance, pose a great threat to human health. New drugs and strategies are thus urgently needed to improve treatment efficacy and limit drug-associated side effects. Nanotechnology-based drug delivery systems are promising approaches, offering hope in the fight against drug resistant bacteria. Read More

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http://dx.doi.org/10.1186/s12951-018-0439-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346558PMC
January 2019
4 Reads

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells.

J Nanobiotechnology 2019 Jan 25;17(1):16. Epub 2019 Jan 25.

Department of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza, Campus Río Ebro-Edificio I+D, C/ Mariano Esquillor S/N, 50018, Zaragoza, Spain.

Background: Exosomes are considered key elements for communication between cells, but very little is known about the mechanisms and selectivity of the transference processes involving exosomes released from different cells.

Results: In this study we have investigated the transfer of hollow gold nanoparticles (HGNs) between different cells when these HGNs were loaded within exosomes secreted by human placental mesenchymal stem cells (MSCs). These HGNs were successfully incorporated in the MSCs exosome biogenesis pathway and released as HGNs-loaded exosomes. Read More

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http://dx.doi.org/10.1186/s12951-018-0437-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346572PMC
January 2019
1 Read

Enamel remineralization and repair results of Biomimetic Hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste.

J Nanobiotechnology 2019 Jan 25;17(1):17. Epub 2019 Jan 25.

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161, Rome, Italy.

Background: Dental caries is a recognized worldwide public health problem. Despite being one of the most effective strategies against dental caries, the excessive use of fluorine may result in a potential risk of developing dental fluorosis especially in children under age of six. The purpose of this work is to analyze a fluorine-free toothpaste containing Biomimetic Hydroxyapatite to assess enamel re-mineralizing and repairing properties. Read More

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http://dx.doi.org/10.1186/s12951-019-0454-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346538PMC
January 2019

Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats.

J Nanobiotechnology 2019 Jan 25;17(1):18. Epub 2019 Jan 25.

Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.

Background: Cyclosporin A (CsA) is a promising therapeutic drug for myocardial ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening of mitochondrial permeability transition pore (mPTP). However, the application of cyclosporin A to treat MI/RI is limited due to its immunosuppressive effect to other normal organ and tissues. SS31 represents a novel mitochondria-targeted peptide which can guide drug to accumulate into mitochondria. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0451-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346555PMC
January 2019
5 Reads

A milk-based self-assemble rotavirus VP6-ferritin nanoparticle vaccine elicited protection against the viral infection.

J Nanobiotechnology 2019 Jan 22;17(1):13. Epub 2019 Jan 22.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, 530004, Guangxi, China.

Background: Rotavirus is the leading cause of severe dehydrating diarrhea in young children and the inner capsid protein VP6 is a potential vaccine candidate that can induce cross-protective immune responses against different Rotavirus strains. The use of ferritin nanoparticles as the scaffold of the antigen can improve the immunogenicity of the subunit vaccines and provide broader protection. We here present a non-live and self-assemble recombinant rotavirus VP6-ferritin (rVP6-ferritin) nanoparticle vaccine. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0446-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341625PMC
January 2019
3 Reads

Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway.

J Nanobiotechnology 2019 Jan 22;17(1):11. Epub 2019 Jan 22.

Department of Prosthodontics, New York University College of Dentistry, New York, NY, 10010, USA.

Background: We developed a non-viral vector, a combination of HIV-1 Tat peptide modified with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high efficiency of plasmid DNA transfection with little toxicity. Since the highest efficiency of INTERFERin (INT), a cationic amphiphilic lipid-based reagent, for small interfering RNA (siRNA) transfection among six commercial reagents was shown, we hypothesized that combining mTat/PEI with INT would improve transfection efficiency of siRNA delivery. To elucidate the efficacy of the hybrid vector for siRNA silencing, β-actin expression was measured after siRNA β-actin was transfected with mTat/PEI/INT or other vectors in HSC-3 human oral squamous carcinoma cells. Read More

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http://dx.doi.org/10.1186/s12951-019-0444-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341701PMC
January 2019

NEP-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury.

J Nanobiotechnology 2019 Jan 22;17(1):12. Epub 2019 Jan 22.

Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.

Background: Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes and administration routes. Albumin-based nanoparticles, which can encapsulate therapeutic drugs and release cargo in a controlled pattern, show high biocompatibility and low toxicity. The Nogo protein, expressed on the surface of oligodendrocytes, can inhibit axonal growth by binding with the axonal Nogo receptor (NgR). Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0449-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341626PMC
January 2019
4 Reads

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field.

J Nanobiotechnology 2019 Jan 22;17(1):14. Epub 2019 Jan 22.

Department of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain.

Background: T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these therapies. Read More

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http://dx.doi.org/10.1186/s12951-019-0440-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341614PMC
January 2019
1 Read
4.078 Impact Factor

Endoplasmic reticulum stress: major player in size-dependent inhibition of P-glycoprotein by silver nanoparticles in multidrug-resistant breast cancer cells.

J Nanobiotechnology 2019 Jan 22;17(1). Epub 2019 Jan 22.

Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary.

Background: Development of multidrug resistance (MDR) is a major burden of successful chemotherapy, therefore, novel approaches to defeat MDR are imperative. Although the remarkable anti-cancer propensity of silver nanoparticles (AgNP) has been demonstrated and their potential application in MDR cancer has been proposed, the nanoparticle size-dependent cellular events directing P-glycoprotein (Pgp) expression and activity in MDR cancer have never been addressed. Hence, in the present study we examined AgNP size-dependent cellular features in multidrug resistant breast cancer cells. Read More

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http://dx.doi.org/10.1186/s12951-019-0448-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341731PMC
January 2019
1 Read
4.078 Impact Factor

Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis.

J Nanobiotechnology 2019 Jan 22;17(1):10. Epub 2019 Jan 22.

Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.

Background: Osteoporosis is a bone-incapacitating malady and it is characterized by obvious bone mass loss and bone microarchitecture deterioration. Current treatments for osteoporosis have many limitations, including the non-obvious therapeutic effect and long-term safety issues. Icariin is a pharmacologically active flavonoid glycoside, which shows potential application in treatment of osteoporosis. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0447-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341739PMC
January 2019
7 Reads

Integration of phospholipid-complex nanocarrier assembly with endogenous N-oleoylethanolamine for efficient stroke therapy.

J Nanobiotechnology 2019 Jan 19;17(1). Epub 2019 Jan 19.

Department of Basic Medical Science, Medical College, Xiamen University, Xiamen, 361102, China.

Background: Leading to more and more deaths and disabilities, stroke has become a serious threat to human health. What's more, few effective drugs are available in clinic till now.

Results: In this research, we prepared a novel neuroprotective nanoformation (OEA-SPC NPs) via the combination of the nanoparticle drug delivery system with the endogenous N-oleoylethanolamine (OEA). Read More

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http://dx.doi.org/10.1186/s12951-019-0442-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339692PMC
January 2019
3 Reads

Retraction Note to: Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line.

J Nanobiotechnology 2019 01 19;17(1). Epub 2019 Jan 19.

Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

The Editors have retracted this article [1] because Figs. 6a and 6c have been used in three other publications to represent scanning electron micrographs of different nanoparticles [2-4]. The data reported in this article are therefore unreliable. Read More

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http://dx.doi.org/10.1186/s12951-018-0434-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339430PMC
January 2019
4.078 Impact Factor

Epitope-loaded nanoemulsion delivery system with ability of extending antigen release elicits potent Th1 response for intranasal vaccine against Helicobacter pylori.

J Nanobiotechnology 2019 Jan 19;17(1). Epub 2019 Jan 19.

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, China.

Background: Helicobacter pylori (H. pylori) infection remains a global public health issue, especially in Asia. Due to the emergence of antibiotic-resistant strains and the complexity of H. Read More

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http://dx.doi.org/10.1186/s12951-019-0441-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339695PMC
January 2019
3 Reads

Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin-QDs nano-hybrids: covalent coupling and phospholipid complexation approaches.

J Nanobiotechnology 2019 Jan 19;17(1). Epub 2019 Jan 19.

Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.

Background: The rationale of this study is to combine the merits of both albumin nanoparticles and quantum dots (QDs) in improved drug tumor accumulation and strong fluorescence imaging capability into one carrier. However, premature drug release from protein nanoparticles and high toxicity of QDs due to heavy metal leakage are among challenging hurdles. Following this platform, we developed cancer nano-theranostics by coupling biocompatible albumin backbone to CdTe QDs and mannose moieties to enhance tumor targeting and reduce QDs toxicity. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0445-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339697PMC
January 2019
6 Reads

Correction to: Highly sensitive and robust peroxidase-like activity of Au-Pt core/shell nanorod-antigen conjugates for measles virus diagnosis.

J Nanobiotechnology 2019 Jan 10;17(1). Epub 2019 Jan 10.

CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing, 100190, China.

After publication of the original article [1], an error was noted in the author affiliation. Lin Long is also affiliated to the College of Opto-electronic Engineering, Zaozhuang University, Zaozhuang, China, which is her first affiliation. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0435-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327458PMC
January 2019
5 Reads

In vivo MRI assessment of bioactive magnetic iron oxide/human serum albumin nanoparticle delivery into the posterior segment of the eye in a rat model of retinal degeneration.

J Nanobiotechnology 2019 Jan 10;17(1). Epub 2019 Jan 10.

Sackler Faculty of Medicine, Tel-Aviv University, 69978, Tel-Aviv, Israel.

Background: Retinal degeneration diseases affect millions of patients worldwide and lead to incurable vision loss. These diseases are caused by pathologies in the retina and underlying choroid, located in the back of the eye. One of the major challenges in the development of treatments for these blinding diseases is the safe and efficient delivery of therapeutics into the back of the eye. Read More

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http://dx.doi.org/10.1186/s12951-018-0438-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327435PMC
January 2019

Comparative mouse lung injury by nickel nanoparticles with differential surface modification.

J Nanobiotechnology 2019 Jan 7;17(1). Epub 2019 Jan 7.

Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40209, USA.

Background: Previous studies have demonstrated that exposure to nickel nanoparticles (Nano-Ni) causes oxidative stress and severe, persistent lung inflammation, which are strongly associated with pulmonary toxicity. However, few studies have investigated whether surface modification of Nano-Ni could alter Nano-Ni-induced lung injury, inflammation, and fibrosis in vivo. Here, we propose that alteration of physicochemical properties of Nano-Ni through modification of Nano-Ni surface may change Nano-Ni-induced lung injury, inflammation, and fibrosis. Read More

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http://dx.doi.org/10.1186/s12951-018-0436-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322282PMC
January 2019
7 Reads

Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires.

J Nanobiotechnology 2019 Jan 7;17(1). Epub 2019 Jan 7.

Biomarker Branch, National Cancer Center, 323 Ilsan-ro, Ilsan-dong-gu, Goyang, Gyeonggi, 10408, South Korea.

Background: Tumor-derived exosomes are gaining attention as important factors that facilitate communication between neighboring cells and manipulate cellular processes associated with cancer development or progression. The conventional techniques for the isolation and detection of exosomes face several limitations, restricting their clinical applications. Hence, a highly efficient technique for the isolation and identification of exosomes from biological samples may provide critical information about exosomes as biomarkers and improve our understanding of their unique role in cancer research. Read More

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http://dx.doi.org/10.1186/s12951-018-0433-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322342PMC
January 2019
5 Reads

Anti-ICAM-1 antibody-modified nanostructured lipid carriers: a pulmonary vascular endothelium-targeted device for acute lung injury therapy.

J Nanobiotechnology 2018 Dec 29;16(1):105. Epub 2018 Dec 29.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, People's Republic of China.

Background: Acute lung injury (ALI) is a life-threatening clinical syndrome without effective treatment. Targeting delivery of glucocorticoid to lung shows potential efficacy for ALI based on their anti-inflammatory and anti-fibrotic properties, breaking through their clinical application limitation due to systemic side effects. This work was aimed to establish lung-targeted dexamethasone (DEX) loaded nanostructured lipid carriers (NLCs) with opposite surface charge and investigate their therapeutic effects on lipopolysaccharide (LPS)-induced ALI mice. Read More

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http://dx.doi.org/10.1186/s12951-018-0431-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311082PMC
December 2018
8 Reads

Gold nanorods-conjugated TiO nanoclusters for the synergistic combination of phototherapeutic treatments of cancer cells.

J Nanobiotechnology 2018 Dec 20;16(1):104. Epub 2018 Dec 20.

Department of Chemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea.

Background: Recently, a combination of photodynamic therapy (PDT) and photothermal therapy (PTT) to generate reactive oxygen species (ROS) and heat to kill cancer cells, respectively has attracted considerable attention because it gives synergistic effects on the cancer treatment by utilizing the radiation of nontoxic low-energy photons such as long wavelength visible light and near IR (NIR) penetrating into subcutaneous region. For the effective combination of the phototherapies, various organic photosensitizer-conjugated gold nanocomplexes have been developed, but they have still some disadvantages due to photobleaching and unnecessary energy transfer of the organic photosensitizers.

Results: In this study, we fabricated novel inorganic phototherapeutic nanocomplexes (Au NR-TiO NCs) by conjugating gold nanorods (Au NRs) with defective TiO nanoparticle clusters (d-TiO NP clusters) and characterized their optical and photothermal properties. Read More

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http://dx.doi.org/10.1186/s12951-018-0432-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300922PMC
December 2018
1 Read

Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma.

J Nanobiotechnology 2018 Dec 20;16(1):103. Epub 2018 Dec 20.

School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.

Background: Sorafenib is an effective clinical drug in therapy of hepatocellular carcinoma, having led to improved prognosis in hepatocellular carcinoma patients. However acquired resistance is still being encountered. So, it is urgently to develop alternative strategies to overcome drug resistance. Read More

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http://dx.doi.org/10.1186/s12951-018-0429-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300915PMC
December 2018
4.078 Impact Factor

Application of atomic force microscopy in cancer research.

J Nanobiotechnology 2018 Dec 11;16(1):102. Epub 2018 Dec 11.

The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and molecules. Recent advances have enabled its application in cancer research and diagnosis. The physicochemical properties of live cells undergo changes when their physiological conditions are altered. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0428-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288943PMC
December 2018
9 Reads

An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer.

J Nanobiotechnology 2018 Dec 8;16(1):101. Epub 2018 Dec 8.

NMR Research Centre, Indian Institute of Science, Bangalore, 560012, India.

We introduce a self-assembling polypeptide-based nanotube system having the ability to specifically target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface. While the nanotubes are non-toxic towards cells in general, they can be loaded with suitable drugs to be released in a sustained manner in cancer cells. Read More

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http://dx.doi.org/10.1186/s12951-018-0427-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286583PMC
December 2018
2 Reads

Assessment of in vitro particle dosimetry models at the single cell and particle level by scanning electron microscopy.

J Nanobiotechnology 2018 Dec 7;16(1):100. Epub 2018 Dec 7.

Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), Campus North, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

Background: Particokinetic models are important to predict the effective cellular dose, which is key to understanding the interactions of particles with biological systems. For the reliable establishment of dose-response curves in, e.g. Read More

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http://dx.doi.org/10.1186/s12951-018-0426-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284276PMC
December 2018

Specific cancer stem cell-therapy by albumin nanoparticles functionalized with CD44-mediated targeting.

J Nanobiotechnology 2018 Dec 1;16(1):99. Epub 2018 Dec 1.

Department of Pharmacy, Third Affiliated Hospital & Research Institute of Surgery of Army Medical University, 10# Changjiangzhilu, Chongqing, 400042, People's Republic of China.

Background: Cancer stem cells (CSCs) are highly proliferative and tumorigenic, which contributes to chemotherapy resistance and tumor occurrence. CSCs specific therapy may achieve excellent therapeutic effects, especially to the drug-resistant tumors.

Results: In this study, we developed a kind of targeting nanoparticle system based on cationic albumin functionalized with hyaluronic acid (HA) to target the CD44 overexpressed CSCs. Read More

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http://dx.doi.org/10.1186/s12951-018-0424-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271611PMC
December 2018

Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin pathway.

J Nanobiotechnology 2018 Nov 29;16(1):98. Epub 2018 Nov 29.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.

Background: Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention.

Methods: In a previous study, novel lanthanum phosphate (LaPO)/chitosan (CS) scaffolds were prepared by distributing 40- to 60-nm LaPO nanoparticles throughout plate-like CS films.

Results: Interconnected three dimensional (3D) macropores within the scaffolds increased the scaffold osteoconductivity, thereby promoting cell adhesion and bone tissue in-growth. Read More

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http://dx.doi.org/10.1186/s12951-018-0411-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263548PMC
November 2018

In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis.

J Nanobiotechnology 2018 Nov 27;16(1):97. Epub 2018 Nov 27.

Department of Ophthalmology, King's College London, Westminster Bridge Road, London, SE1 7EH, UK.

Background: Sustained drug delivery is a large unmet clinical need in glaucoma. Here, we incorporated a Myocardin-Related Transcription Factor/Serum Response Factor inhibitor, CCG-222740, into slow release large unilamellar vesicles derived from the liposomes DOTMA (1,2-di-O-octadecenyl-3-trimethylammonium propane) and DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine), and tested their effects in vitro and in vivo.

Results: The vesicles were spherical particles of around 130 nm and were strongly cationic. Read More

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http://dx.doi.org/10.1186/s12951-018-0425-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258153PMC
November 2018
6 Reads

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties.

J Nanobiotechnology 2018 Nov 27;16(1):96. Epub 2018 Nov 27.

NIFE-Lower Saxony Centre for Biomedical Engineering, Implant Research and Development, Clinic for Orthopedic Surgery, Hannover Medical School, Stadtfelddamm 34, 30625, Hannover, Germany.

Background: In orthopedic surgery, implant-associated infections are still a major problem. For the improvement of the selective therapy in the infection area, magnetic nanoparticles as drug carriers are promising when used in combination with magnetizable implants and an externally applied magnetic field. These implants principally increase the strength of the magnetic field resulting in an enhanced accumulation of the drug loaded particles in the target area and therewith a reduction of the needed amount and the risk of undesirable side effects. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0422-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258308PMC
November 2018
6 Reads

Nanomaterial enabled sensors for environmental contaminants.

J Nanobiotechnology 2018 Nov 22;16(1):95. Epub 2018 Nov 22.

Department of Civil and Environmental Engineering and the Institute for Critical Technology and Applied Science, Center for Sustainable Nanotechnology (VTSuN), Virginia Tech, Blacksburg, USA.

The need and desire to understand the environment, especially the quality of one's local water and air, has continued to expand with the emergence of the digital age. The bottleneck in understanding the environment has switched from being able to store all of the data collected to collecting enough data on a broad range of contaminants of environmental concern. Nanomaterial enabled sensors represent a suite of technologies developed over the last 15 years for the highly specific and sensitive detection of environmental contaminants. Read More

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http://dx.doi.org/10.1186/s12951-018-0419-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249933PMC
November 2018

Novel self-assembling conjugates as vectors for agrochemical delivery.

J Nanobiotechnology 2018 Nov 21;16(1):94. Epub 2018 Nov 21.

School of Life and Environmental Sciences, Deakin University, Waurn Ponds Campus, Geelong, VIC, 3217, Australia.

Background: Modern agricultural practises rely on surfactant-based spray applications to eliminate weeds in crops. The wide spread and indiscriminate use of surfactants may result in a number of deleterious effects that are not limited to impacts on the crop and surrounding farm eco-system but include effects on human health. To provide a safer alternative to the use of surfactant-based formulations, we have synthesised a novel, self-assembling herbicide conjugate for the delivery of a broad leaf herbicide, picloram. Read More

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http://dx.doi.org/10.1186/s12951-018-0423-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247628PMC
November 2018
8 Reads

Ni-hemin metal-organic framework with highly efficient peroxidase catalytic activity: toward colorimetric cancer cell detection and targeted therapeutics.

J Nanobiotechnology 2018 Nov 20;16(1):93. Epub 2018 Nov 20.

Cellular and Molecular Reserch Center, Kurdistan University of Medical Sciences, 66177-13446, Sananandaj, Iran.

Background: Given the great benefits of artificial enzymes, a simple approach is proposed via assembling of Ni with hemin for synthesis of Ni-hemin metal-organic-frameworks (Ni-hemin MOFs) mimic enzyme. The formation of the Ni-hemin MOFs was verified by scanning electron microscopy, Transmission electron microscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Energy-dispersive X-ray spectroscopy and UV-vis absorption spectroscopy. This novel nanocomposite exhibited surprising peroxidase like activity monitored by catalytic oxidation of a typical peroxidase substrate, 3,3,5,5'-tetramethylbenzidine, in the presence of HO. Read More

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http://dx.doi.org/10.1186/s12951-018-0421-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245618PMC
November 2018
6 Reads

Hybrid, metal oxide-peptide amphiphile micelles for molecular magnetic resonance imaging of atherosclerosis.

J Nanobiotechnology 2018 Nov 15;16(1):92. Epub 2018 Nov 15.

Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, Los Angeles, CA, 90089, USA.

Background: Atherosclerosis, a major source of cardiovascular disease, is asymptomatic for decades until the activation of thrombosis and the rupture of enlarged plaques, resulting in acute coronary syndromes and sudden cardiac arrest. Magnetic resonance imaging (MRI) is a noninvasive nuclear imaging technique to assess the degree of atherosclerotic plaque with high spatial resolution and excellent soft tissue contrast. However, MRI lacks sensitivity for preventive medicine, which limits the ability to observe the onset of vulnerable plaques. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0420-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238287PMC
November 2018
14 Reads

A novel microemulsion-based isotonic perfusate modulated by Ringer's solution for improved microdialysis recovery of liposoluble substances.

J Nanobiotechnology 2018 Nov 14;16(1):91. Epub 2018 Nov 14.

Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.

Background: Microdialysis is promising technique for dynamic microbiochemical sampling from tissues. However, the application of typical aqueous perfusates to liposoluble substances is limited. In this study, a novel microemulsion (ME)-based isotonic perfusate (RS-ME) was prepared to improve the recovery of liposoluble components using microdialysis probes. Read More

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http://dx.doi.org/10.1186/s12951-018-0418-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237007PMC
November 2018
10 Reads

Biosynthesis of flower-shaped Au nanoclusters with EGCG and their application for drug delivery.

J Nanobiotechnology 2018 Nov 13;16(1):90. Epub 2018 Nov 13.

Cancer Research Center, Medical College, Xiamen University, Xiamen, 361005, China.

Background: In the last decade, the biosynthesis of metal nanoparticles using organisms have received more and more considerations. However, the complex composition of organisms adds up to a great barrier for the characterization of biomolecules involved in the synthesis process and their biological mechanisms.

Results: In this research, we biosynthesized a kind of flower-shaped Au nanoclusters (Au NCs) using one definite component-epigallocatechin gallate (EGCG), which was the main biomolecules of green tea polyphenols. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0417-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233264PMC
November 2018
12 Reads

Nano-silver-incorporated biomimetic polydopamine coating on a thermoplastic polyurethane porous nanocomposite as an efficient antibacterial wound dressing.

J Nanobiotechnology 2018 Nov 12;16(1):89. Epub 2018 Nov 12.

Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Background: Developing an ideal wound dressing that meets the multiple demands of good biocompatibility, an appropriate porous structure, superior mechanical property and excellent antibacterial activity against drug-resistant bacteria is highly desirable for clinical wound care. Biocompatible thermoplastic polyurethane (TPU) membranes are promising candidates as a scaffold; however, their lack of a suitable porous structure and antibacterial activity has limited their application. Antibiotics are generally used for preventing bacterial infections, but the global emergence of drug-resistant bacteria continues to cause social concerns. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0416-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231251PMC
November 2018
16 Reads

Redox nanoparticles: synthesis, properties and perspectives of use for treatment of neurodegenerative diseases.

J Nanobiotechnology 2018 Nov 3;16(1):87. Epub 2018 Nov 3.

Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska Street 141/143, 90-236, Lodz, Poland.

Oxidative stress (OS) and nitrative stress (NS) accompany many diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Antioxidants have been proposed to counteract OS/NS in these diseases. Nevertheless, the effects of antioxidants are limited and new, more efficient antioxidants are searched for. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0412-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215349PMC
November 2018
7 Reads

Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity.

J Nanobiotechnology 2018 Nov 3;16(1):88. Epub 2018 Nov 3.

School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.

Background: We have previously shown that intraperitoneal injection of gold nanoparticles (AuNPs, 20-30 nm) into mice, decreases high-fat diet (HFD) induced weight gain and glucose intolerance, via suppression of inflammatory responses in both fat and liver tissues. This study investigates whether AuNPs provide similar benefit to mice with pre-existing obesity. Male C57BL/6 mice were fed a HFD for 15 weeks. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0414-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215354PMC
November 2018
19 Reads

Orally administered gold nanoparticles protect against colitis by attenuating Toll-like receptor 4- and reactive oxygen/nitrogen species-mediated inflammatory responses but could induce gut dysbiosis in mice.

J Nanobiotechnology 2018 Nov 1;16(1):86. Epub 2018 Nov 1.

Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, 20740, USA.

Background: Gold nanoparticles (AuNPs) are attracting interest as potential therapeutic agents to treat inflammatory diseases, but their anti-inflammatory mechanism of action is not clear yet. In addition, the effect of orally administered AuNPs on gut microbiota has been overlooked so far. Here, we evaluated the therapeutic and gut microbiota-modulating effects, as well as the anti-inflammatory paradigm, of AuNPs with three different coatings and five difference sizes in experimental mouse colitis and RAW264. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-018-0415-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211593PMC
November 2018
2 Reads
4.080 Impact Factor

The impact of nanoparticle-driven lysosomal alkalinization on cellular functionality.

J Nanobiotechnology 2018 Oct 31;16(1):85. Epub 2018 Oct 31.

NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.

Background: The biomedical use of nanosized materials is rapidly gaining interest, which drives the quest to elucidate the behavior of nanoparticles (NPs) in a biological environment. Apart from causing direct cell death, NPs can affect cellular wellbeing through a wide range of more subtle processes that are often overlooked. Here, we aimed to study the effect of two biomedically interesting NP types on cellular wellbeing. Read More

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http://dx.doi.org/10.1186/s12951-018-0413-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208102PMC
October 2018

'Green' synthesis of metals and their oxide nanoparticles: applications for environmental remediation.

J Nanobiotechnology 2018 Oct 30;16(1):84. Epub 2018 Oct 30.

Department of Nano Science and Materials, Central University of Jammu, Jammu, J & K, 180011, India.

In materials science, "green" synthesis has gained extensive attention as a reliable, sustainable, and eco-friendly protocol for synthesizing a wide range of materials/nanomaterials including metal/metal oxides nanomaterials, hybrid materials, and bioinspired materials. As such, green synthesis is regarded as an important tool to reduce the destructive effects associated with the traditional methods of synthesis for nanoparticles commonly utilized in laboratory and industry. In this review, we summarized the fundamental processes and mechanisms of "green" synthesis approaches, especially for metal and metal oxide [e. Read More

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http://dx.doi.org/10.1186/s12951-018-0408-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206834PMC
October 2018
3 Reads