751 results match your criteria Journal of Nanobiotechnology [Journal]


Extracellular silica nanocoat formed by layer-by-layer (LBL) self-assembly confers aluminum resistance in root border cells of pea (Pisum sativum).

J Nanobiotechnology 2019 Apr 16;17(1):53. Epub 2019 Apr 16.

Department of Horticulture, Foshan University, Foshan, 528000, Guangdong, China.

Background: Soil acidity (and associated Al toxicity) is a major factor limiting crop production worldwide and threatening global food security. Electrostatic layer-by-layer (LBL) self-assembly provides a convenient and versatile method to form an extracellular silica nanocoat, which possess the ability to protect cell from the damage of physical stress or toxic substances. In this work, we have tested a hypothesis that extracellular silica nanocoat formed by LBL self-assembly will protect root border cells (RBCs) and enhance their resistance to Al toxicity. Read More

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http://dx.doi.org/10.1186/s12951-019-0486-yDOI Listing
April 2019
1 Read

Environmental hazard assessment for polymeric and inorganic nanobiomaterials used in drug delivery.

J Nanobiotechnology 2019 Apr 16;17(1):56. Epub 2019 Apr 16.

Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland.

Background: The increasing development and use of nanobiomaterials raises questions about their potential adverse effects on the environment after excretion and release. Published ecotoxicological data was searched for five polymeric nanobiomaterials [chitosan, polylactic acid (PLA), polyacrylonitrile (PAN), polyhydroxyalkanoates (PHA), and poly(lactic-glycolic acid) (PLGA)] and one inorganic nanobiomaterial [hydroxyapatite (HAP)] to evaluate the environmental hazards for freshwater and soil using a meta-analysis. If enough data was available, a probabilistic species sensitivity distribution (pSSD) and from this a predicted no effect concentration (PNEC) was calculated. Read More

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http://dx.doi.org/10.1186/s12951-019-0489-8DOI Listing

Bactericidal effects and accelerated wound healing using TbO nanoparticles with intrinsic oxidase-like activity.

J Nanobiotechnology 2019 Apr 16;17(1):54. Epub 2019 Apr 16.

Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, 20740, USA.

Background: Nanomaterials that exhibit intrinsic enzyme-like characteristics have shown great promise as potential antibacterial agents. However, many of them exhibit inefficient antibacterial activity and biosafety problems that limit their usefulness. The development of new nanomaterials with good biocompatibility and rapid bactericidal effects is therefore highly desirable. Read More

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http://dx.doi.org/10.1186/s12951-019-0487-xDOI Listing

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment.

J Nanobiotechnology 2019 Apr 16;17(1):55. Epub 2019 Apr 16.

Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, People's Republic of China.

Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while few researches have reported this point. Recently, oxidative corrosion induced by cellular metabolites has been well concerned. Read More

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http://dx.doi.org/10.1186/s12951-019-0488-9DOI Listing

A randomized, double-blind, placebo-controlled investigation of BCc1 nanomedicine effect on survival and quality of life in metastatic and non-metastatic gastric cancer patients.

J Nanobiotechnology 2019 Apr 10;17(1):52. Epub 2019 Apr 10.

Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Currently, the main goal of cancer research is to increase longevity of patients suffering malignant cancers. The promising results of BCc1 in vitro and vivo experiments made us look into the effect of BCc1 nanomedicine on patients with cancer in a clinical trial.

Methods: The present investigation was a randomized, double-blind, placebo-controlled, parallel, and multicenter study in which 123 patients (30-to-85-year-old men and women) with metastatic and non-metastatic gastric cancer, in two separate groups of BCc1 nanomedicine or placebo, were selected using a permuted block randomization method. Read More

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http://dx.doi.org/10.1186/s12951-019-0484-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458717PMC

Argon plasma modified nanocomposite polyurethane scaffolds provide an alternative strategy for cartilage tissue engineering.

J Nanobiotechnology 2019 Apr 6;17(1):51. Epub 2019 Apr 6.

Division of Surgery & Interventional Science, University College London (UCL), London, UK.

Background: Children born with a small or absent ear undergo surgical reconstruction to create a suitable replacement using rib cartilage. To overcome the donor site morbidity and long-term pain of harvesting rib cartilage, synthetic materials can be a useful alternative. Medpor, is the currently used synthetic polyethylene material to replace missing facial cartilage but unfortunately it has high levels of surgical complications including infection and extrusion, making it an unsuitable replacement. Read More

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http://dx.doi.org/10.1186/s12951-019-0477-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451776PMC

Gelatin-chlorin e6 conjugate for in vivo photodynamic therapy.

J Nanobiotechnology 2019 Apr 5;17(1):50. Epub 2019 Apr 5.

Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Background: Improving the water solubility of hydrophobic photosensitizer and increasing its accumulation in tumor tissue are essential for in vivo photodynamic therapy (PDT). Considering commercialization or clinical application in future, it will be promising to achieve these purposes by developing new agents with simple and non-toxic structure.

Results: We conjugated multiple chlorin e6 (Ce6) molecules to gelatin polymer, synthesizing two types of gelatin-Ce6 conjugates with different amounts of Ce6: gelatin-Ce6-2 and gelatin-Ce6-8. Read More

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http://dx.doi.org/10.1186/s12951-019-0475-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449946PMC

Intracisternal delivery of PEG-coated gold nanoparticles results in high brain penetrance and long-lasting stability.

J Nanobiotechnology 2019 Apr 3;17(1):49. Epub 2019 Apr 3.

Experimental Imaging Centre, San Raffaele Scientific Institute, 20132, Milan, Italy.

Background: The increasing use of gold nanoparticles (AuNPs) in the field of neuroscience instilled hope for their rapid translation to the clinical practice. AuNPs can be engineered to carry therapeutics or diagnostics in the diseased brain, possibly providing greater cell specificity and low toxicity. Although there is a general enthusiasm for these tools, we are in early stages of their development. Read More

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http://dx.doi.org/10.1186/s12951-019-0481-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448280PMC
April 2019
2 Reads

Nanocomposites as biomolecules delivery agents in nanomedicine.

J Nanobiotechnology 2019 Apr 3;17(1):48. Epub 2019 Apr 3.

Department of Applied Toxicology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str, 02-097, Warsaw, Poland.

Nanoparticles (NPs) are atomic clusters of crystalline or amorphous structure that possess unique physical and chemical properties associated with a size range of between 1 and 100 nm. Their nano-sized dimensions, which are in the same range as those of vital biomolecules, such as antibodies, membrane receptors, nucleic acids, and proteins, allow them to interact with different structures within living organisms. Because of these features, numerous nanoparticles are used in medicine as delivery agents for biomolecules. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0479-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448271PMC
April 2019
6 Reads

Silica nanoparticle-exposure during neuronal differentiation modulates dopaminergic and cholinergic phenotypes in SH-SY5Y cells.

J Nanobiotechnology 2019 Apr 1;17(1):46. Epub 2019 Apr 1.

Division of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Bern, Laenggassstrasse 124, 3012, Bern, Switzerland.

Background: Silica-ε-polycaprolactone-nanoparticles (SiPCL-NPs) represent a promising tool for laser-tissue soldering in the brain. After release of the SiPCL-NPs in the brain, neuronal differentiation might be modulated. The present study was performed to determine effects of SiPCL-NP-exposure at different stages of neuronal differentiation in neuron-like SH-SY5Y cells. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0482-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442417PMC
April 2019
4 Reads

Mild thermotherapy and hyperbaric oxygen enhance sensitivity of TMZ/PSi nanoparticles via decreasing the stemness in glioma.

J Nanobiotechnology 2019 Apr 1;17(1):47. Epub 2019 Apr 1.

National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Wuhan, 430074, People's Republic of China.

Background: Glioma is a common brain tumor with a high mortality rate. A small population of cells expressing stem-like cell markers in glioma contributes to drug resistance and tumor recurrence.

Methods: Porous silicon nanoparticles (PSi NPs) as photothermal therapy (PTT) agents loaded with TMZ (TMZ/PSi NPs), was combined with hyperbaric oxygen (HBO) therapy in vitro and in vivo. Read More

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http://dx.doi.org/10.1186/s12951-019-0483-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442425PMC
April 2019
2 Reads

Role of A adenosine receptor-dependent adenosine signaling in multi-walled carbon nanotube-triggered lung fibrosis in mice.

J Nanobiotechnology 2019 Mar 29;17(1):45. Epub 2019 Mar 29.

College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Harbin, 150030, China.

Background: Multi-walled carbon nanotube (MWCNT)-induced lung fibrosis leads to health concerns in human. However, the mechanisms underlying fibrosis pathogenesis remains unclear. The adenosine (ADO) is produced in response to injury and serves a detrimental role in lung fibrosis. Read More

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http://dx.doi.org/10.1186/s12951-019-0478-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440149PMC

Smart nanoplatform for sequential drug release and enhanced chemo-thermal effect of dual drug loaded gold nanorod vesicles for cancer therapy.

J Nanobiotechnology 2019 Mar 27;17(1):44. Epub 2019 Mar 27.

Department of Pharmacy, Nanfang Hospital, School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, China.

Background: The combination of multiple chemotherapeutics has been used in the clinic for enhanced cancer chemotherapy, however, frequent relapse, chemo-resistance and side effects remains therapeutic hurdles. Thus, the development of co-delivery system with enhanced targeting and synergistic different modal treatments has been proposed as promising strategies for intensive improvement of the therapeutic outcomes.

Results: We fabricated a nanocarrier based on gold nanorods (Au NRs), cRGD peptide-modified and multi-stimuli-responsive paclitaxel (PTX) and curcumin (CUR) release for synergistic anticancer effect and chemo-photothermal therapy (PTX/CUR/Au NRs@cRGD). Read More

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http://dx.doi.org/10.1186/s12951-019-0473-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437988PMC
March 2019
1 Read

CdSSe nanowire-chip based wearable sweat sensor.

J Nanobiotechnology 2019 Mar 26;17(1):42. Epub 2019 Mar 26.

Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems, School of Physics, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.

Background: Sweat, as an easily accessible bodily fluid, is enriched with a lot of physiological and health information. A portable and wearable sweat sensor is an important device for an on-body health monitoring. However, there are only few such devices to monitor sweat. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0480-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434865PMC
March 2019
5 Reads

A sensitive gold-nanorods-based nanobiosensor for specific detection of Campylobacter jejuni and Campylobacter coli.

J Nanobiotechnology 2019 Mar 26;17(1):43. Epub 2019 Mar 26.

Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Jalal-Ale-Ahmad Ave, Tehran, 14117-13116, Iran.

Background: Campylobacteriosis is a zoonotic infectious disease that can be mostly undiagnosed or unreported due to fastidious Campylobacter species. The aim of this study was to develop a simple, sensitive, and quick assay for the detection of Campylobacter spp. and taking advantage of the great sensitivity of gold nanorods (GNRs) to trace changes in the local environment and interparticle distance. Read More

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http://dx.doi.org/10.1186/s12951-019-0476-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434641PMC
March 2019
1 Read

SF-1 mediates reproductive toxicity induced by Cerium oxide nanoparticles in male mice.

J Nanobiotechnology 2019 Mar 21;17(1):41. Epub 2019 Mar 21.

School of Public Health, Medical College of Soochow University, Suzhou, 215123, China.

Background: Cerium oxide nanoparticles (CeO NPs) have potential application for use in biomedical and in various consumer products. However, it is largely unclear whether CeO NPs have effects on male reproductive function.

Methods: In this study, male mice were examined for toxicity, if any, following chronic oral administration of CeO NPs for 32 days. Read More

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http://dx.doi.org/10.1186/s12951-019-0474-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427857PMC
March 2019
12 Reads

Volume discrimination of nanoparticles via electrical trapping using nanopores.

J Nanobiotechnology 2019 Mar 14;17(1):40. Epub 2019 Mar 14.

The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka, 567-0047, Japan.

Electrophoretic capture of an oversized object on a solid-state nanopore is a useful approach for single-particle analyses via post electrical and optical measurements. Here we report on nanoparticle discriminations by the volume through combining this nanopore trap method with the cross-membrane ionic current measurements. We investigated ion transport through a pore channel being partially occluded by an electrophoretically-drawn nanoparticle at the orifice. Read More

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http://dx.doi.org/10.1186/s12951-019-0471-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419447PMC

A facile preparation of FePt-loaded few-layer MoS nanosheets nanocomposites (F-MoS-FePt NCs) and their application for colorimetric detection of HO in living cells.

J Nanobiotechnology 2019 Mar 13;17(1):38. Epub 2019 Mar 13.

Collage of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, China.

Background: Rapid and sensitive detection of HO especially endogenous HO is of great importance for series of industries including disease diagnosis and therapy. In this work, uniform FePt nanoparticles are successfully anchored onto Few-layer molybdenum disulfide nanosheets (F-MoS NSs). The powder X-ray diffraction, transmission electron microscopy, UV-Vis spectra and atomic force microscopy were employed to confirm the structure of the obtained nanocomposites (F-MoS-FePt NCs). Read More

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http://dx.doi.org/10.1186/s12951-019-0465-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417205PMC
March 2019
1 Read

Uptake and distribution of carboxylated quantum dots in human mesenchymal stem cells: cell growing density matters.

J Nanobiotechnology 2019 Mar 13;17(1):39. Epub 2019 Mar 13.

Biomedical Physics Laboratory, National Cancer Institute, Baublio Str. 3b, 08406, Vilnius, Lithuania.

Background: Human mesenchymal stem cells (MSCs) have drawn much attention in the field of regenerative medicine for their immunomodulatory and anti-inflammatory effects. MSCs possess specific tumor-oriented migration and incorporation highlighting the potential for MSCs to be used as an ideal carrier for anticancer agents. Bone marrow is the main source of MSCs for clinical applications. Read More

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http://dx.doi.org/10.1186/s12951-019-0470-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417192PMC
March 2019
1 Read

Engineered magnetosomes fused to functional molecule (protein A) provide a highly effective alternative to commercial immunomagnetic beads.

J Nanobiotechnology 2019 Mar 6;17(1):37. Epub 2019 Mar 6.

College of Life Science, Huaibei Normal University, Huaibei, 235000, China.

Background: Magnetosomes (also called bacterial magnetic nanoparticles; BMPs) are biomembrane-coated nanoparticles synthesized by magnetotactic bacteria (MTB). Engineered BMPs fused to protein A (termed ∆F-BMP-FA) bind antibodies (Abs) automatically, and thus provide a series of potential advantages. However, no report so far has systematically evaluated functional applicability of genetically engineered BMPs. Read More

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http://dx.doi.org/10.1186/s12951-019-0469-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402170PMC
March 2019
2 Reads
4.078 Impact Factor

Correction to: Pluronic‑based nano‑self‑assemblies of bacitracin A with a new mechanism of action for an efficient in vivo therapeutic effect against bacterial peritonitis.

J Nanobiotechnology 2019 Mar 6;17(1):36. Epub 2019 Mar 6.

Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Dongling Road 120, Shenyang, 110866, Liaoning, People's Republic of China.

In the original publication of the article [1], the Fig. 8c and d was published with incorrect values. The corrected Fig. Read More

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http://dx.doi.org/10.1186/s12951-019-0464-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402112PMC

Nanobody-horseradish peroxidase fusion protein as an ultrasensitive probe to detect antibodies against Newcastle disease virus in the immunoassay.

J Nanobiotechnology 2019 Mar 1;17(1):35. Epub 2019 Mar 1.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Background: Sensitive and specific antibodies can be used as essential probes to develop competitive enzyme-linked immunosorbent assay (cELISA). However, traditional antibodies are difficult to produce, only available in limited quantities, and ineffective as enzymatic labels. Nanobodies, which are single-domain antibodies (sdAbs), offer an alternative, more promising tool to circumvent these limitations. Read More

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http://dx.doi.org/10.1186/s12951-019-0468-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396497PMC
March 2019
4 Reads
4.078 Impact Factor

Establishment of perpendicular protrusion of type I collagen on TiO nanotube surface as a priming site of peri-implant connective fibers.

J Nanobiotechnology 2019 Mar 1;17(1):34. Epub 2019 Mar 1.

Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, USA.

Natural teeth are supported by connective tissue collagen fibers that insert perpendicularly in the tooth cementum. Perpendicular insertion plays an important role in the maintenance of the junction between the oral epithelium and the periodontal connective tissue. Most titanium dental implant surfaces have no micro or macro structure to support perpendicularly oriented collagen attachment. Read More

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http://dx.doi.org/10.1186/s12951-019-0467-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396481PMC
March 2019
3 Reads

Correction to: Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents.

J Nanobiotechnology 2019 Feb 28;17(1):33. Epub 2019 Feb 28.

School of Medicine, Faculty of Health, Centre for Molecular and Medical Research, Deakin University, Locked Bag 20000, Geelong, Victoria, 3220, Australia.

After publication of the original article [1], the authors found that Figure 2e (Hsp70-Ch-Lf-ZF in Jurkat cells, 2 h), Figure 5b (HSP70-Lf-ZF) and Figure 5c (control) contained incorrect images. This does not affect the figure legends, results and conclusions of the article. Read More

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http://dx.doi.org/10.1186/s12951-019-0443-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394032PMC
February 2019

Evaluation of the elastic Young's modulus and cytotoxicity variations in fibroblasts exposed to carbon-based nanomaterials.

J Nanobiotechnology 2019 Feb 23;17(1):32. Epub 2019 Feb 23.

Departamento de Ingeniería Eléctrica y Electrónica, Universidad de Los Andes, Bogotá D.C., Colombia.

Background: The conventional approaches to assess the potential cytotoxic effects of nanomaterials (NMs) mainly rely on in vitro biochemical assays. These assays are strongly dependent on the properties of the nanomaterials, for example; specific surface area (SSA), size, surface defects, and surface charge, and the host response. The NMs properties can also interfere with the reagents of the biochemical and optical assays leading to skewed interpretations and ambiguous results related to the NMs toxicity. Read More

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http://dx.doi.org/10.1186/s12951-019-0460-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387485PMC
February 2019
7 Reads

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice.

J Nanobiotechnology 2019 Feb 19;17(1):29. Epub 2019 Feb 19.

The Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.

Background: Accumulating evidence shows that microRNA-210 (miR-210) holds great promise to improve angiogenesis for brain tissue repair after cerebral ischemia. However, safe and efficient delivery of miR-210 via intravenous administration is still a challenge. In the past decade, exosomes have emerged as a novel endogenous delivery system. Read More

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http://dx.doi.org/10.1186/s12951-019-0461-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379944PMC
February 2019
1 Read
4.078 Impact Factor

Random and aligned electrospun PLGA nanofibers embedded in microfluidic chips for cancer cell isolation and integration with air foam technology for cell release.

J Nanobiotechnology 2019 Feb 19;17(1):31. Epub 2019 Feb 19.

Research Center for Applied Sciences, Academia Sinica, Taipei, 11529, Taiwan.

Background: Circulating tumor cells (CTCs) comprise the high metastatic potential population of cancer cells in the blood circulation of humans; they have become the established biomarkers for cancer diagnosis, individualized cancer therapy, and cancer development. Technologies for the isolation and recovery of CTCs can be powerful cancer diagnostic tools for liquid biopsies, allowing the identification of malignancies and guiding cancer treatments for precision medicine.

Methods: We have used an electrospinning process to prepare poly(lactic-co-glycolic acid) (PLGA) nanofibrous arrays in random or aligned orientations on glass slips. Read More

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http://dx.doi.org/10.1186/s12951-019-0466-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379968PMC
February 2019
5 Reads

Chlorotoxin peptide-functionalized polyethylenimine-entrapped gold nanoparticles for glioma SPECT/CT imaging and radionuclide therapy.

J Nanobiotechnology 2019 Feb 19;17(1):30. Epub 2019 Feb 19.

Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.

Background: Malignant glioma is the most common and deadliest brain cancer due to the obstacle from indistinct tumor margins for surgical excision and blood brain barrier (BBB) for chemotherapy. Here, we designed and prepared multifunctional polyethylenimine-entrapped gold nanoparticles (Au PENPs) for targeted SPECT/CT imaging and radionuclide therapy of glioma.

Results: Polyethylenimine was selected as a template for sequential modification with polyethylene glycol (PEG), glioma-specific peptide (chlorotoxin, CTX) and 3-(4-hydroxyphenyl)propionic acid-OSu (HPAO), and were then used to entrap gold nanoparticles (Au NPs). Read More

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http://dx.doi.org/10.1186/s12951-019-0462-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380014PMC
February 2019

Correction to: Binding mechanism of anti-cancer chemotherapeutic drug mitoxantrone to DNA characterized by magnetic tweezers.

J Nanobiotechnology 2019 Feb 8;17(1):28. Epub 2019 Feb 8.

Experimental Biophysics and Applied Nanoscience, Physics Department, Bielefeld Institute for Nanoscience (BINAS), Bielefeld University, Universitaetsstrasse 25, 33615, Bielefeld, Germany.

Following publication of this article [1] we found a typographical error in the results reported in the abstract. The corrected sentences should read as below. Read More

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http://dx.doi.org/10.1186/s12951-018-0430-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367820PMC
February 2019

Real-time in vivo imaging of subpopulations of circulating tumor cells using antibody conjugated quantum dots.

J Nanobiotechnology 2019 Feb 6;17(1):26. Epub 2019 Feb 6.

Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.

Introduction: The detection of circulating tumor cells (CTCs) is very important for cancer diagnosis. CTCs can travel from primary tumors through the circulation to form secondary tumor colonies via bloodstream extravasation. The number of CTCs has been used as an indicator of cancer progress. Read More

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http://dx.doi.org/10.1186/s12951-019-0453-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364392PMC
February 2019

Long-term live cells observation of internalized fluorescent Fe@C nanoparticles in constant magnetic field.

J Nanobiotechnology 2019 Feb 6;17(1):27. Epub 2019 Feb 6.

Faculté de Médecine, Université François Rabelais, 37032, Tours, France.

Background: Theranostics application of superparamagnetic nanoparticles based on magnetite and maghemite is impeded by their toxicity. The use of additional protective shells significantly reduced the magnetic properties of the nanoparticles. Therefore, iron carbides and pure iron nanoparticles coated with multiple layers of onion-like carbon sheath seem to be optimal for biomedicine. Read More

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http://dx.doi.org/10.1186/s12951-019-0463-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364403PMC
February 2019
2 Reads

Specific drug delivery efficiently induced human breast tumor regression using a lipoplex by non-covalent association with anti-tumor antibodies.

J Nanobiotechnology 2019 Feb 6;17(1):25. Epub 2019 Feb 6.

Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, 30068, Taiwan, ROC.

Background: A cationic liposome-PEG-PEI complex (LPPC) was employed as a carrier for achieving targeted delivery of drug to human epidermal growth factor receptor-2 (HER2/neu)-expressing breast cancer cells. LPPC can be easily loaded with an anti-tumor drug and non-covalently associated with an anti-tumor antibody such as Herceptin that is clinically used to rapidly form immunoparticles within 1 h.

Results: Drug-loaded LPPC have an average size about 250 nm and a zeta potential of about 40 mV. Read More

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http://dx.doi.org/10.1186/s12951-019-0457-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364477PMC
February 2019
11 Reads
4.078 Impact Factor

Two distinct cellular pathways leading to endothelial cell cytotoxicity by silica nanoparticle size.

J Nanobiotechnology 2019 Feb 5;17(1):24. Epub 2019 Feb 5.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

Background: Silica nanoparticles (SiNPs) are widely used for biosensing and diagnostics, and for the targeted delivery of therapeutic agents. Safety concerns about the biomedical and clinical applications of SiNPs have been raised, necessitating analysis of the effects of their intrinsic properties, such as sizes, shapes, and surface physicochemical characteristics, on human health to minimize risk in biomedical applications. In particular, SiNP size-associated toxicological effects, and the underlying molecular mechanisms in the vascular endothelium remain unclear. Read More

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http://dx.doi.org/10.1186/s12951-019-0456-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362579PMC
February 2019
2 Reads

Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin.

J Nanobiotechnology 2019 Feb 2;17(1):22. Epub 2019 Feb 2.

Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222, Bialystok, Poland.

Background: Human plasma gelsolin (pGSN) is a multifunctional actin-binding protein involved in a variety of biological processes, including neutralization of pro-inflammatory molecules such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA) and modulation of host inflammatory response. It was found that PBP10, a synthetic rhodamine B-conjugated peptide, based on the phosphoinositide-binding site of pGSN, exerts bactericidal activity against Gram-positive and Gram-negative bacteria, interacts specifically with LPS and LTA, and limits microbial-induced inflammatory effects. The therapeutic efficiency of PBP10 when immobilized on the surface of iron oxide-based magnetic nanoparticles was not evaluated, to date. Read More

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http://dx.doi.org/10.1186/s12951-019-0455-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359803PMC
February 2019
2 Reads
4.078 Impact Factor

From one to all: self-assembled theranostic nanoparticles for tumor-targeted imaging and programmed photoactive therapy.

J Nanobiotechnology 2019 Feb 2;17(1):23. Epub 2019 Feb 2.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, No. 11 First North Road, Zhongguancun, Beijing, 100190, China.

Background: In recent years, multifunctional theranostic nanoparticles have been fabricated by integrating imaging and therapeutic moieties into one single nano-formulations. However, Complexity of production and safety issues limits their further application.

Results: Herein, we demonstrated self-assembled nanoparticles with single structure as a "from one to all" theranostic platform for tumor-targeted dual-modal imaging and programmed photoactive therapy (PPAT). Read More

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http://dx.doi.org/10.1186/s12951-019-0450-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359812PMC
February 2019
2 Reads

Indoor nanoscale particulate matter-induced coagulation abnormality based on a human 3D microvascular model on a microfluidic chip.

J Nanobiotechnology 2019 Feb 1;17(1):20. Epub 2019 Feb 1.

Hubei Key Laboratory for Processing and Transformation of Agricultural Products (Wuhan Polytechnic University), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, 430023, People's Republic of China.

Background: A growing body of evidence shows that indoor concentrations of airborne particles are often higher than is typically encountered outdoors. Since exposure to indoor PM2.5 is thought to be associated with cardiovascular disease, the health impacts of indoor air pollution need to be explored. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0458-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357445PMC
February 2019
3 Reads
4.078 Impact Factor

High time resolution and high signal-to-noise monitoring of the bacterial growth kinetics in the presence of plasmonic nanoparticles.

J Nanobiotechnology 2019 Feb 1;17(1):21. Epub 2019 Feb 1.

Bacterial Infections: Antimicrobial Therapies, Institute for Bioengineering of Catalonia (IBEC), The Institute of Science and Technology, Baldiri Reixac 15-21, 08028, Barcelona, Spain.

Background: Emerging concepts for designing innovative drugs (i.e., novel generations of antimicrobials) frequently include nanostructures, new materials, and nanoparticles (NPs). Read More

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http://dx.doi.org/10.1186/s12951-019-0459-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357367PMC
February 2019

Lecithin nano-liposomal particle as a CRISPR/Cas9 complex delivery system for treating type 2 diabetes.

J Nanobiotechnology 2019 Jan 29;17(1):19. Epub 2019 Jan 29.

College of Pharmacy, Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 Worldcup-ro, Yeongtong-gu, Suwon, 16499, South Korea.

Background: Protein-based Cas9 in vivo gene editing therapeutics have practical limitations owing to their instability and low efficacy. To overcome these obstacles and improve stability, we designed a nanocarrier primarily consisting of lecithin that can efficiently target liver disease and encapsulate complexes of Cas9 with a single-stranded guide RNA (sgRNA) ribonucleoprotein (Cas9-RNP) through polymer fusion self-assembly.

Results: In this study, we optimized an sgRNA sequence specifically for dipeptidyl peptidase-4 gene (DPP-4) to modulate the function of glucagon-like peptide 1. Read More

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http://dx.doi.org/10.1186/s12951-019-0452-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350399PMC
January 2019
3 Reads

Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection.

J Nanobiotechnology 2019 Jan 25;17(1):15. Epub 2019 Jan 25.

Mycobacterial Genetics Unit, Institut Pasteur, Paris, France.

Background: Infectious diseases are still a leading cause of death and, with the emergence of drug resistance, pose a great threat to human health. New drugs and strategies are thus urgently needed to improve treatment efficacy and limit drug-associated side effects. Nanotechnology-based drug delivery systems are promising approaches, offering hope in the fight against drug resistant bacteria. Read More

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http://dx.doi.org/10.1186/s12951-018-0439-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346558PMC
January 2019
15 Reads

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells.

J Nanobiotechnology 2019 Jan 25;17(1):16. Epub 2019 Jan 25.

Department of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza, Campus Río Ebro-Edificio I+D, C/ Mariano Esquillor S/N, 50018, Zaragoza, Spain.

Background: Exosomes are considered key elements for communication between cells, but very little is known about the mechanisms and selectivity of the transference processes involving exosomes released from different cells.

Results: In this study we have investigated the transfer of hollow gold nanoparticles (HGNs) between different cells when these HGNs were loaded within exosomes secreted by human placental mesenchymal stem cells (MSCs). These HGNs were successfully incorporated in the MSCs exosome biogenesis pathway and released as HGNs-loaded exosomes. Read More

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http://dx.doi.org/10.1186/s12951-018-0437-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346572PMC
January 2019
2 Reads

Enamel remineralization and repair results of Biomimetic Hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste.

J Nanobiotechnology 2019 Jan 25;17(1):17. Epub 2019 Jan 25.

Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161, Rome, Italy.

Background: Dental caries is a recognized worldwide public health problem. Despite being one of the most effective strategies against dental caries, the excessive use of fluorine may result in a potential risk of developing dental fluorosis especially in children under age of six. The purpose of this work is to analyze a fluorine-free toothpaste containing Biomimetic Hydroxyapatite to assess enamel re-mineralizing and repairing properties. Read More

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http://dx.doi.org/10.1186/s12951-019-0454-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346538PMC
January 2019

Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats.

J Nanobiotechnology 2019 Jan 25;17(1):18. Epub 2019 Jan 25.

Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.

Background: Cyclosporin A (CsA) is a promising therapeutic drug for myocardial ischemia reperfusion injury (MI/RI) because of its definite inhibition to the opening of mitochondrial permeability transition pore (mPTP). However, the application of cyclosporin A to treat MI/RI is limited due to its immunosuppressive effect to other normal organ and tissues. SS31 represents a novel mitochondria-targeted peptide which can guide drug to accumulate into mitochondria. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0451-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346555PMC
January 2019
9 Reads

A milk-based self-assemble rotavirus VP6-ferritin nanoparticle vaccine elicited protection against the viral infection.

J Nanobiotechnology 2019 Jan 22;17(1):13. Epub 2019 Jan 22.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, 530004, Guangxi, China.

Background: Rotavirus is the leading cause of severe dehydrating diarrhea in young children and the inner capsid protein VP6 is a potential vaccine candidate that can induce cross-protective immune responses against different Rotavirus strains. The use of ferritin nanoparticles as the scaffold of the antigen can improve the immunogenicity of the subunit vaccines and provide broader protection. We here present a non-live and self-assemble recombinant rotavirus VP6-ferritin (rVP6-ferritin) nanoparticle vaccine. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0446-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341625PMC
January 2019
8 Reads

Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway.

J Nanobiotechnology 2019 Jan 22;17(1):11. Epub 2019 Jan 22.

Department of Prosthodontics, New York University College of Dentistry, New York, NY, 10010, USA.

Background: We developed a non-viral vector, a combination of HIV-1 Tat peptide modified with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high efficiency of plasmid DNA transfection with little toxicity. Since the highest efficiency of INTERFERin (INT), a cationic amphiphilic lipid-based reagent, for small interfering RNA (siRNA) transfection among six commercial reagents was shown, we hypothesized that combining mTat/PEI with INT would improve transfection efficiency of siRNA delivery. To elucidate the efficacy of the hybrid vector for siRNA silencing, β-actin expression was measured after siRNA β-actin was transfected with mTat/PEI/INT or other vectors in HSC-3 human oral squamous carcinoma cells. Read More

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http://dx.doi.org/10.1186/s12951-019-0444-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341701PMC
January 2019

NEP-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury.

J Nanobiotechnology 2019 Jan 22;17(1):12. Epub 2019 Jan 22.

Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.

Background: Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes and administration routes. Albumin-based nanoparticles, which can encapsulate therapeutic drugs and release cargo in a controlled pattern, show high biocompatibility and low toxicity. The Nogo protein, expressed on the surface of oligodendrocytes, can inhibit axonal growth by binding with the axonal Nogo receptor (NgR). Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12951-019-0449-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341626PMC
January 2019
5 Reads

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field.

J Nanobiotechnology 2019 Jan 22;17(1):14. Epub 2019 Jan 22.

Department of Immunology and Oncology, and NanoBiomedicine Initiative, Centro Nacional de Biotecnología (CNB)-CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain.

Background: T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these therapies. Read More

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http://dx.doi.org/10.1186/s12951-019-0440-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341614PMC
January 2019
2 Reads
4.078 Impact Factor

Endoplasmic reticulum stress: major player in size-dependent inhibition of P-glycoprotein by silver nanoparticles in multidrug-resistant breast cancer cells.

J Nanobiotechnology 2019 Jan 22;17(1). Epub 2019 Jan 22.

Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary.

Background: Development of multidrug resistance (MDR) is a major burden of successful chemotherapy, therefore, novel approaches to defeat MDR are imperative. Although the remarkable anti-cancer propensity of silver nanoparticles (AgNP) has been demonstrated and their potential application in MDR cancer has been proposed, the nanoparticle size-dependent cellular events directing P-glycoprotein (Pgp) expression and activity in MDR cancer have never been addressed. Hence, in the present study we examined AgNP size-dependent cellular features in multidrug resistant breast cancer cells. Read More

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http://dx.doi.org/10.1186/s12951-019-0448-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341731PMC
January 2019
2 Reads
4.078 Impact Factor

Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis.

J Nanobiotechnology 2019 Jan 22;17(1):10. Epub 2019 Jan 22.

Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, China.

Background: Osteoporosis is a bone-incapacitating malady and it is characterized by obvious bone mass loss and bone microarchitecture deterioration. Current treatments for osteoporosis have many limitations, including the non-obvious therapeutic effect and long-term safety issues. Icariin is a pharmacologically active flavonoid glycoside, which shows potential application in treatment of osteoporosis. Read More

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https://jnanobiotechnology.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/s12951-019-0447-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341739PMC
January 2019
14 Reads

Integration of phospholipid-complex nanocarrier assembly with endogenous N-oleoylethanolamine for efficient stroke therapy.

J Nanobiotechnology 2019 Jan 19;17(1). Epub 2019 Jan 19.

Department of Basic Medical Science, Medical College, Xiamen University, Xiamen, 361102, China.

Background: Leading to more and more deaths and disabilities, stroke has become a serious threat to human health. What's more, few effective drugs are available in clinic till now.

Results: In this research, we prepared a novel neuroprotective nanoformation (OEA-SPC NPs) via the combination of the nanoparticle drug delivery system with the endogenous N-oleoylethanolamine (OEA). Read More

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http://dx.doi.org/10.1186/s12951-019-0442-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339692PMC
January 2019
7 Reads

Retraction Note to: Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line.

J Nanobiotechnology 2019 01 19;17(1). Epub 2019 Jan 19.

Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

The Editors have retracted this article [1] because Figs. 6a and 6c have been used in three other publications to represent scanning electron micrographs of different nanoparticles [2-4]. The data reported in this article are therefore unreliable. Read More

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http://dx.doi.org/10.1186/s12951-018-0434-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339430PMC
January 2019
1 Read
4.078 Impact Factor