2,874 results match your criteria Journal of Molecular Medicine [Journal]


Correction to: Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma.

J Mol Med (Berl) 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology, College of Medicine, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan.

In Fig. 1b, upper part, the cell viability counts after treatment with cisplatin and TSA in T24 cells was by mistake a duplication of the image for NTUB1 on the left. In the corrected version of Fig. Read More

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http://dx.doi.org/10.1007/s00109-019-01748-2DOI Listing
February 2019

Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells.

J Mol Med (Berl) 2019 Feb 10. Epub 2019 Feb 10.

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, 53127, Germany.

NLRP3 inflammasome activation in the retinal pigment epithelium (RPE) is observed in atrophic age-related macular degeneration (AMD), and pharmacological NLRP3 inhibition may provide a therapeutic strategy to halt disease progression. We tested selective NLRP3 inhibitors (IFM-514, IFM-632, and CRID3) for their efficacy in human and murine RPE cells. Inflammasome activation was induced in primary human RPE cells and ARPE-19 cells following priming with IL-1α by different stimuli, including lysosomal membrane permeabilization by leucyl-leucine methyl ester (Leu-Leu-OMe), oxidative damage induced by hydrogen peroxide, lipofuscin-mediated photooxidative damage induced by incubation with 4-hydroxynonenal-modified photoreceptor outer segments and subsequent blue light irradiation, and P2X7 receptor activation by benzoylbenzoyl-ATP. Read More

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http://dx.doi.org/10.1007/s00109-019-01753-5DOI Listing
February 2019
1 Read

Exploring the roles of MSCs in infections: focus on bacterial diseases.

J Mol Med (Berl) 2019 Feb 7. Epub 2019 Feb 7.

Department of Experimental, Diagnostic and Specialty Medicine, Unit of Histology, Embryology and Applied Biology, University of Bologna, Via Belmeloro 8, 40126, Bologna, Italy.

Despite human healthcare advances, some microorganisms continuously react evolving new survival strategies, choosing between a commensal fitness and a pathogenic attitude. Many opportunistic microbes are becoming an increasing cause of clinically evident infections while several renowned infectious diseases sustain a considerable number of deaths. Besides the primary and extensively investigated role of immune cells, other cell types are involved in the microbe-host interaction during infection. Read More

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http://link.springer.com/10.1007/s00109-019-01752-6
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http://dx.doi.org/10.1007/s00109-019-01752-6DOI Listing
February 2019
2 Reads

FOXM1 plays a role in autophagy by transcriptionally regulating Beclin-1 and LC3 genes in human triple-negative breast cancer cells.

J Mol Med (Berl) 2019 Feb 7. Epub 2019 Feb 7.

Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Triple-negative breast cancer (TNBC) is associated with poor prognosis owing to its aggressive and heterogeneous nature, and the lack of therapeutic targets. Although Forkhead Box M1 (FOXM1) is one of the most important oncogenes contributing to tumorigenesis, progression, and drug resistance in TNBC, the underlying molecular mechanisms are not well understood. Emerging evidence indicates that autophagy plays a critical role in cell survival and protective mechanism in TNBC. Read More

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http://dx.doi.org/10.1007/s00109-019-01750-8DOI Listing
February 2019
1 Read

MicroRNA-145 targets Smad1 in endometrial stromal cells and regulates decidualization in rat.

J Mol Med (Berl) 2019 Feb 7. Epub 2019 Feb 7.

Division of Endocrinology, CSIR-Central Drug Research Institute|, Lucknow, Uttar Pradesh, 226031, India.

Decidualization of endometrial stromal cells is the pre-requisite for the embryo implantation and establishment of pregnancy. Although known to be regulated by several factors, the process of regulation of decidualization by miRNAs is largely unknown. Previous reports suggest that the upregulated expression of miR-145 is associated with repeated implantation failure. Read More

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http://dx.doi.org/10.1007/s00109-019-01744-6DOI Listing
February 2019
1 Read

MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction.

J Mol Med (Berl) 2019 Feb 6. Epub 2019 Feb 6.

State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, School of Pharmacy, Air Force Medical University, No. 169 West Chang-le Road, Xi'an, 710032, People's Republic of China.

The postmenopausal state is associated with an increased risk of metabolic disorder including reduced energy expenditure and weight gain, leading to higher cardiovascular and cancer risks among other diseases. Mitochondrial-derived peptide (MOTS-c) is a 16-amino acid peptide encoded by mitochondrial DNA. Here, we showed that MOTS-c treatment in mice prevented ovariectomy-induced obesity and insulin resistance. Read More

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http://dx.doi.org/10.1007/s00109-018-01738-wDOI Listing
February 2019
1 Read
5.107 Impact Factor

AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model.

J Mol Med (Berl) 2019 Feb 5. Epub 2019 Feb 5.

Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Westmead, NSW, 2145, Australia.

Recent studies have indicated that the Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway is closely involved in liver fibrosis and other fibrotic diseases. However, whether targeting the AMPK pathway can rescue liver fibrosis and its complications, such as portal hypertension, is unknown. This study aimed to explore the therapeutic value of AICAR (5-aminoimidazole-4-carboxyamide ribonucleoside), an agonist of the AMPK pathway, on liver fibrosis and portal hypertension in bile duct ligation (BDL) rats. Read More

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http://dx.doi.org/10.1007/s00109-019-01746-4DOI Listing
February 2019
3 Reads

MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells.

J Mol Med (Berl) 2019 Feb 4. Epub 2019 Feb 4.

Central Laboratory, Harbin Medical University (Daqing), Daqing, 163319, People's Republic of China.

MicroRNAs have been considered to participate in pulmonary arterial hypertension (PAH) and regulate numerous disease pathways in pulmonary vasculature. However, the molecular role in the pathologies has not yet been fully uncovered, particularly in the view of energy metabolism and vascular smooth muscle cell phenotypic regulation. Here, several altered miRNAs are founded in genome-wide miRNA sequencing analysis, in which miR-449a-5p was identified as a probable candidate in hypoxic PAH and verified such a decreasing trend. Read More

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http://dx.doi.org/10.1007/s00109-019-01751-7DOI Listing
February 2019
5.107 Impact Factor

Role of sirtuin-1 in diabetic nephropathy.

J Mol Med (Berl) 2019 Feb 1. Epub 2019 Feb 1.

Pediatric Research Institute, Department of Pediatrics, The University of Louisville School of Medicine, Louisville, KY, 40292, USA.

Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several mechanisms have been shown to be involved in its pathogenesis and many useful drugs have been developed, the management of DN remains challenging. Increasing amounts of evidence show that silent information regulator 2 homolog 1 (sirtuin-1), a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase, plays a crucial role in the pathogenesis and development of DN. Read More

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http://dx.doi.org/10.1007/s00109-019-01743-7DOI Listing
February 2019
2 Reads

Are glutamate transporters neuroprotective or neurodegenerative during cerebral ischemia?

J Mol Med (Berl) 2019 Jan 23. Epub 2019 Jan 23.

Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei, China.

The accumulation of glutamate (Glu) in the synaptic cleft during cerebral ischemia triggers the death of neurons, causing mental or physical handicap. However, the mechanisms of the alteration in Glu homeostasis and the imbalance between the release and clearance of Glu in ischemia are not yet completely understood. Additionally, the role of Glu transporters in regulating Glu concentration in the synaptic cleft is controversial. Read More

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http://dx.doi.org/10.1007/s00109-019-01745-5DOI Listing
January 2019

Follicular helper T cell and memory B cell immunity in CHC patients.

J Mol Med (Berl) 2019 Jan 21. Epub 2019 Jan 21.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, 130021, China.

Chronic hepatitis C (CHC) is associated with biological activity of T follicular helper (Tfh) cells and memory B cells (MBCs). However, the nature of Tfh cell subsets that are responsible for MBCs in CHC patients has not been evaluated. This study aimed to investigate Tfh and MBC immunity before and after direct-acting antiviral (DAA) therapy in patients with CHC. Read More

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http://dx.doi.org/10.1007/s00109-018-01735-zDOI Listing
January 2019
2 Reads

IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans.

J Mol Med (Berl) 2019 Jan 19. Epub 2019 Jan 19.

Department of Medical Biotechnology and Laboratory Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

NADPH is a reducing equivalent that maintains redox homeostasis and supports reductive biosynthesis. Lack of major NADPH-producing enzymes predisposes cells to growth retardation and demise. It was hypothesized that double deficiency of the NADPH-generating enzymes, GSPD-1 (Glucose-6-phosphate 1-dehydrogenase), a functional homolog of human glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, and IDH-1 (isocitrate dehydrogenase-1) affect growth and development in the nematode, Caenorhabditis elegans (C. Read More

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http://dx.doi.org/10.1007/s00109-018-01740-2DOI Listing
January 2019

Suppression of Syk activation by resveratrol inhibits MSU crystal-induced inflammation in human monocytes.

J Mol Med (Berl) 2019 Jan 12. Epub 2019 Jan 12.

Department of Biomedical Sciences, and BK21 Plus Biomedical Science Project, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Monosodium urate (MSU) crystals are an endogenous sterile particulate that has been identified as a potent damage-associated molecular pattern (DAMP). In humans, the induction of IL-1β production through MSU-induced NLRP3 inflammasome activation in monocytes/macrophages is responsible for pathogenesis of gouty arthritis. It was recently reported that in a murine model of this disease, resveratrol decreases MSU-induced recurrent attacks of gouty arthritis. Read More

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http://link.springer.com/10.1007/s00109-018-01736-y
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http://dx.doi.org/10.1007/s00109-018-01736-yDOI Listing
January 2019
6 Reads

NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation.

J Mol Med (Berl) 2019 Jan 8. Epub 2019 Jan 8.

Institut National de la Santé et de la Recherche Médicale, Unité 1036, Grenoble, France.

Fetal growth restriction (FGR) the leading cause of perinatal mortality and morbidity is highly related to abnormal placental development, and placentas from FGR pregnancies are often characterized by increased inflammation. However, the mechanisms of FGR-associated inflammation are far from being understood. NLRP7, a member of a family of receptors involved in the innate immune responses, has been shown to be associated with gestational trophoblastic diseases. Read More

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http://dx.doi.org/10.1007/s00109-018-01737-xDOI Listing
January 2019

Pathological role of apoptosis signal-regulating kinase 1 in human diseases and its potential as a therapeutic target for cognitive disorders.

J Mol Med (Berl) 2019 Feb 7;97(2):153-161. Epub 2019 Jan 7.

Department of Life Science, College of Science and Engineering, Kyonggi University, 154-42 Gwanggyosan-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16227, Republic of Korea.

Cognitive disorders are among the leading causes of health and social issues, as well as socioeconomic burden. Cognitive dysfunction associated with diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, diabetes, and stroke can lead to dementia. Despite extensive efforts, strategies for the prevention and treatment of cognitive dysfunction are scarce. Read More

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http://dx.doi.org/10.1007/s00109-018-01739-9DOI Listing
February 2019

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.

J Mol Med (Berl) 2019 Jan 7. Epub 2019 Jan 7.

MediCity Research Laboratory, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.

ATP and adenosine are important signaling molecules involved in vascular remodeling, retinal function, and neurovascular coupling in the eye. Current knowledge on enzymatic pathways governing the duration and magnitude of ocular purinergic signaling is incompletely understood. By employing sensitive analytical assays, this study dissected ocular purine homeostasis as a complex and coordinated network. Read More

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http://dx.doi.org/10.1007/s00109-018-01734-0DOI Listing
January 2019
2 Reads

Calreticulin regulates MYCN expression to control neuronal differentiation and stemness of neuroblastoma.

J Mol Med (Berl) 2019 Jan 5. Epub 2019 Jan 5.

Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan.

Oncogenic N-MYC (MYCN) is widely used as a biomarker in clinics for neuroblastoma (NB) patients; nevertheless, mechanism that underlines MYCN regulation remains elusive. In the present study, we identified calreticulin (CRT) as a novel MYCN suppressor that downregulated MYCN promoter activity and protein expression to modulate neuronal differentiation and stemness. Our data showed that CRT-mediated MYCN suppression led to increased neurite length and commensurate elevation in differentiation marker GAP-43. Read More

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http://dx.doi.org/10.1007/s00109-018-1730-xDOI Listing
January 2019

An endothelial cell line infected by Kaposi's sarcoma-associated herpes virus (KSHV) allows the investigation of Kaposi's sarcoma and the validation of novel viral inhibitors in vitro and in vivo.

J Mol Med (Berl) 2019 Jan 4. Epub 2019 Jan 4.

Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124, Braunschweig, Germany.

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), a tumor of endothelial origin predominantly affecting immunosuppressed individuals. Up to date, vaccines and targeted therapies are not available. Screening and identification of anti-viral compounds are compromised by the lack of scalable cell culture systems reflecting properties of virus-transformed cells in patients. Read More

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http://dx.doi.org/10.1007/s00109-018-01733-1DOI Listing
January 2019
5.107 Impact Factor

Nuclear localization of LDL receptor-related protein 1B in mammary gland carcinogenesis.

J Mol Med (Berl) 2019 Feb 3;97(2):257-268. Epub 2019 Jan 3.

Department of Surgical Oncology, Gifu University, Gifu University Graduate School of Medicine, Gifu, Japan.

LRP1B intracellular domain is released and transported to the nucleus; however, pathological consequences of this nuclear transport are largely unclear. We aimed to unravel the pathobiological significance of nuclear localization of LRP1B intracellular domain in mammary gland carcinogenesis. Immunohistochemical staining using antibodies for LRP1B intracellular domain was performed to determine LRP1B expression in 92 invasive ductal breast carcinomas. Read More

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http://dx.doi.org/10.1007/s00109-018-01732-2DOI Listing
February 2019

Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1.

J Mol Med (Berl) 2019 Feb 3;97(2):269-279. Epub 2019 Jan 3.

Interfaculty Institute of Biochemistry, University of Tübingen, 72076, Tübingen, Germany.

The yeast protein Taz1 is the orthologue of human Tafazzin, a phospholipid acyltransferase involved in cardiolipin (CL) remodeling via a monolyso CL (MLCL) intermediate. Mutations in Tafazzin lead to Barth syndrome (BTHS), a metabolic and neuromuscular disorder that primarily affects the heart, muscles, and immune system. Similar to observations in fibroblasts and platelets from patients with BTHS or from animal models, abolishing yeast Taz1 results in decreased total CL amounts, increased levels of MLCL, and mitochondrial dysfunction. Read More

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http://dx.doi.org/10.1007/s00109-018-1728-4DOI Listing
February 2019

Cancer-associated fibroblasts promote the stemness of CD24 liver cells via paracrine signaling.

J Mol Med (Berl) 2019 Feb 18;97(2):243-255. Epub 2018 Dec 18.

Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China.

Cancer stem cells (CSCs), which support tumor progress in hepatocellular carcinoma (HCC) developed in fibrotic or cirrhotic livers, are regulated by the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the major component of the tumor stroma in HCC; however, the mechanisms by which CAFs contribute to stemness maintenance remain largely unknown. Here, we found that the expression of CD24 was high in HCC tissues compared with adjacent normal liver tissues, and positively correlated with the poor prognosis and α-SMA expression in CAFs. Read More

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http://dx.doi.org/10.1007/s00109-018-1731-9DOI Listing
February 2019
1 Read

Approaches to therapeutic angiogenesis for ischemic heart disease.

J Mol Med (Berl) 2019 Feb 15;97(2):141-151. Epub 2018 Dec 15.

Morehouse School of Medicine, Cardiovascular Research Institute, 720 Westview Drive SW, Atlanta, GA, 30310, USA.

Ischemic heart disease (IHD) is caused by the narrowing of arteries that work to provide blood, nutrients, and oxygen to the myocardial tissue. The worldwide epidemic of IHD urgently requires innovative treatments despite the significant advances in medical, interventional, and surgical therapies for this disease. Angiogenesis is a physiological and pathophysiological process that initiates vascular growth from pre-existing blood vessels in response to a lack of oxygen. Read More

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http://dx.doi.org/10.1007/s00109-018-1729-3DOI Listing
February 2019
3 Reads

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.

J Mol Med (Berl) 2019 Feb 11;97(2):231-242. Epub 2018 Dec 11.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

No tyrosine kinase inhibitors are approved for malignant pleural mesothelioma (MPM). Preclinical studies identified focal adhesion kinase (FAK) as a target in MPM. Accordingly, we assessed the novel, highly selective FAK inhibitor (BI 853520) in 2D and 3D cultures and in vivo. Read More

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http://link.springer.com/10.1007/s00109-018-1725-7
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http://dx.doi.org/10.1007/s00109-018-1725-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348072PMC
February 2019
10 Reads

Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome.

J Mol Med (Berl) 2019 Feb 7;97(2):201-213. Epub 2018 Dec 7.

Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Sinusoidal obstruction syndrome (SOS) is a major complication after hematopoietic stem cell transplantation and belongs to a group of diseases increasingly identified as transplant-related systemic endothelial disease. Administration of defibrotide affords some protection against SOS, but the effect is modest. Hence, there is unmet medical need justifying the preclinical search for alternative approaches. Read More

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http://dx.doi.org/10.1007/s00109-018-1726-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348071PMC
February 2019
1 Read

Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease.

J Mol Med (Berl) 2019 Feb 8;97(2):215-229. Epub 2018 Dec 8.

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and retinal ganglion cell death long term. Therefore, alternative treatments that target common upstream disease mechanisms are needed. Read More

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http://link.springer.com/10.1007/s00109-018-1727-5
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http://dx.doi.org/10.1007/s00109-018-1727-5DOI Listing
February 2019
3 Reads

Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.

J Mol Med (Berl) 2019 Feb 30;97(2):189-199. Epub 2018 Nov 30.

Department of Pathology, Chongqing Medical University, Yixueyuan Road 1, 400016, Chongqing, People's Republic of China.

Astrocytes are involved in neuroprotection, and DJ-1 is an important antioxidant protein that is abundantly expressed in reactive astrocytes. However, the role of DJ-1 in astrocytes' neuroprotection in cerebral ischemia/reperfusion injury and its potential mechanism is unclear. Thus, to explore effects and mechanisms of DJ-1 on the neuroprotection of astrocytes, we used primary co-cultures of neurons and astrocytes under oxygen and glucose deprivation/reoxygenation in vitro and transient middle cerebral artery occlusion/reperfusion in vivo to mimic ischemic reperfusion insult. Read More

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http://dx.doi.org/10.1007/s00109-018-1719-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348070PMC
February 2019
1 Read

Coexpression of FOXK1 and vimentin promotes EMT, migration, and invasion in gastric cancer cells.

J Mol Med (Berl) 2019 Feb 27;97(2):163-176. Epub 2018 Nov 27.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

In human gastric cancer (GC), the upregulation of FOXK1 and vimentin is frequently observed in cancer cells and correlates with increased malignancy. We report that FOXK1 synergizes with vimentin to promote GC invasion and metastasis via the induction of epithelial-mesenchymal transition (EMT). We showed that higher expression levels of FOXK1 were significantly associated with GC development. Read More

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http://dx.doi.org/10.1007/s00109-018-1720-zDOI Listing
February 2019
5.107 Impact Factor

Interleukin-23 receptor signaling mediates cancer dormancy and radioresistance in human esophageal squamous carcinoma cells via the Wnt/Notch pathway.

J Mol Med (Berl) 2019 Feb 27;97(2):177-188. Epub 2018 Nov 27.

Institute of Oncology, Affiliated Hospital of Jiangsu University, Jiefang Road 438, Zhenjiang, 212001, China.

In the tumor microenvironment, inflammatory cells and molecules influence almost every process; among them, interleukin-23 (IL-23) is a pro-inflammatory molecule that exhibits pro- or anti-tumor properties, but both activities remain poorly understood. In this study, we investigated the effect of extracellular IL-23 in IL-23 receptor-positive (IL-23R) esophageal squamous cell carcinoma (ESCC) and explored the mechanisms underlying this effect. We analyzed ESCC tumor tissues by immunohistochemical and immunofluorescence staining and found that IL-23, which was highly expressed, co-localized with Oct-4A in IL-23R ESCC cells. Read More

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http://dx.doi.org/10.1007/s00109-018-1724-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348073PMC
February 2019

KIAA1199 promotes invasion and migration in non-small-cell lung cancer (NSCLC) via PI3K-Akt mediated EMT.

J Mol Med (Berl) 2019 Jan 26;97(1):127-140. Epub 2018 Nov 26.

Department of Clinical Biobank, Nantong University Affiliated Hospital, Nantong, 226001, Jiangsu, China.

KIAA1199 is often upregulated in cancer cells, including non-small-cell lung cancer (NSCLC). Although KIAA1199 is associated with aggressive tumor phenotype and poor survival in NSCLC, little is known about its functional role in NSCLC progression. Using archived clinical samples, we evaluated KIAA1199 messenger RNA (mRNA) and protein expression in NSCLC tissues and correlated with NSCLC clinicopathological characteristics as well as overall survival. Read More

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http://dx.doi.org/10.1007/s00109-018-1721-yDOI Listing
January 2019
1 Read
5.107 Impact Factor

Long non-coding RNA H19 inhibition promotes hyperglycemia in mice by upregulating hepatic FoxO1 levels and promoting gluconeogenesis.

J Mol Med (Berl) 2019 Jan 21;97(1):115-126. Epub 2018 Nov 21.

CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India.

In a previous report from our laboratory, it was reported that hepatic levels of the long non-coding RNA (lncRNA), H19 are decreased in diabetic mice which elevates hepatic gluconeogenesis and glucose output. But, the mechanisms of H19 inhibition in elevating gluconeogenic genes' transcription and promoting hepatic glucose output were not known. In this study, we aimed to decipher this regulatory role of H19 on glucose metabolism and on FoxO1, an important transcriptional regulator of gluconeogenesis. Read More

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http://dx.doi.org/10.1007/s00109-018-1718-6DOI Listing
January 2019
9 Reads

Inhibition of YAP with siRNA prevents cartilage degradation and ameliorates osteoarthritis development.

J Mol Med (Berl) 2019 Jan 21;97(1):103-114. Epub 2018 Nov 21.

Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.

The Hippo/YAP signaling pathway is important for mediating organ size and tissue homeostasis, but its role in osteoarthritis (OA) remains unclear. We aimed to investigate the role of Hippo/YAP signaling pathway in OA development. YAP expression in OA cartilage was assessed by immunohistochemistry, RT-qPCR, and Western blotting. Read More

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http://dx.doi.org/10.1007/s00109-018-1705-yDOI Listing
January 2019
18 Reads
5.107 Impact Factor

Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer.

J Mol Med (Berl) 2019 Jan 20;97(1):89-102. Epub 2018 Nov 20.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) play an important role in the metastasis and chemoresistance in the context of colorectal cancer (CRC). Downregulation of death associated protein kinase 1 (DAPK1) may promote metastasis and chemoresistance of cancer cells through various mechanisms. However, the association between DAPK1 and CSCs or EMT has not been explored. Read More

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http://dx.doi.org/10.1007/s00109-018-1716-8DOI Listing
January 2019
1 Read

Dichotomal functions of phosphorylated and unphosphorylated STAT1 in hepatocellular carcinoma.

J Mol Med (Berl) 2019 Jan 19;97(1):77-88. Epub 2018 Nov 19.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Room Na-617, 's-Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands.

Interferons (IFNs) with antiviral and immune-stimulatory functions have been widely used in prevention and treatment of hepatocellular carcinoma (HCC). Signal transducer and activator of transcription 1 (STAT1) is a key element of the IFN signaling, and the function of STAT1 is critically determined by its phosphorylation state. This study aims to understand the functions of phosphorylated (p-) and unphosphorylated (u-) STAT1 in HCC. Read More

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http://link.springer.com/10.1007/s00109-018-1717-7
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http://dx.doi.org/10.1007/s00109-018-1717-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326978PMC
January 2019
12 Reads

Valproic acid exerts specific cellular and molecular anti-inflammatory effects in post-operative conjunctiva.

J Mol Med (Berl) 2019 Jan 19;97(1):63-75. Epub 2018 Nov 19.

Ocular Therapeutics and Drug Delivery, Singapore Eye Research Institute, The Academia, 20 College Road, Singapore, 169856, Singapore.

Valproic acid (VPA) is a histone deacetylase inhibitor used clinically for neurological disorders. It is also potentially useful as anti-fibrotic therapy as it reduced collagen deposition in the post-operative conjunctiva. In this study, we further evaluated the effects of VPA on post-operative inflammation using the mouse model of conjunctival scarring. Read More

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http://dx.doi.org/10.1007/s00109-018-1722-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326969PMC
January 2019
1 Read

Emerging role of circadian rhythm in bone remodeling.

J Mol Med (Berl) 2019 Jan 16;97(1):19-24. Epub 2018 Nov 16.

Department of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, 214041, Jiangsu, China.

The 24-h rhythm of behavioral and physiological processes is a typical biological phenomenon regulated by a group of circadian rhythm genes. Dysfunction of the circadian rhythm can cause a wide range of problems, such as cancer and metabolic diseases. In recent decades, increased understanding of the roles of circadian rhythm genes in the bone remodeling process have been documented, including osteoblastic bone formation, osteoclastic bone resorption, and osteoblast/osteoclast communication. Read More

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http://link.springer.com/10.1007/s00109-018-1723-9
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http://dx.doi.org/10.1007/s00109-018-1723-9DOI Listing
January 2019
15 Reads

Macrophage-derived CCL18 promotes osteosarcoma proliferation and migration by upregulating the expression of UCA1.

J Mol Med (Berl) 2019 Jan 13;97(1):49-61. Epub 2018 Nov 13.

Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Xuhui District, Shanghai City, 200233, China.

Osteosarcoma (OS), which is the most common primary malignant bone tumor, has a high incidence of pulmonary metastasis. CCL18 (C-C motif chemokine ligand 18), which is secreted by tumor-associated macrophages (TAMs), has been found to be increased in various tumors and is associated with tumor metastasis. However, the role of CCL18 in OS remains unclear. Read More

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http://link.springer.com/10.1007/s00109-018-1711-0
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http://dx.doi.org/10.1007/s00109-018-1711-0DOI Listing
January 2019
8 Reads

ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits.

Authors:
Tom Hearn

J Mol Med (Berl) 2019 Jan 12;97(1):1-17. Epub 2018 Nov 12.

Institute of Life Science, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK.

Alström syndrome (AS) is characterised by metabolic deficits, retinal dystrophy, sensorineural hearing loss, dilated cardiomyopathy and multi-organ fibrosis. Elucidating the function of the mutated gene, ALMS1, is critical for the development of specific treatments and may uncover pathways relevant to a range of other disorders including common forms of obesity and type 2 diabetes. Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. Read More

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http://link.springer.com/10.1007/s00109-018-1714-x
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http://dx.doi.org/10.1007/s00109-018-1714-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327082PMC
January 2019
13 Reads

Identification of molecular signatures involved in radiation-induced lung fibrosis.

J Mol Med (Berl) 2019 Jan 7;97(1):37-47. Epub 2018 Nov 7.

Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, South Korea.

In radiotherapy, radiation (IR)-induced lung fibrosis has severe and dose-limiting side effects. To elucidate the molecular effects of IR fibrosis, we examined the fibrosis process in irradiated mouse lung tissues. High focal IR (90 Gy) was exposed to a 3-mm volume of the left lung in C57BL6 mice. Read More

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http://link.springer.com/10.1007/s00109-018-1715-9
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http://dx.doi.org/10.1007/s00109-018-1715-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326977PMC
January 2019
18 Reads

Propionibacterium acnes induces discogenic low back pain via stimulating nucleus pulposus cells to secrete pro-algesic factor of IL-8/CINC-1 through TLR2-NF-κB p65 pathway.

J Mol Med (Berl) 2019 Jan 6;97(1):25-35. Epub 2018 Nov 6.

Department of Orthopedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China.

Latent infection of Propionibacterium acnes was considered as a new pathogeny for low back pain (LBP); however, there is no credible animal evidence or mechanism hypothesis. This study proved that P. acnes is a causative pathogen of bacteria-induced LBP and investigated its underlying mechanism. Read More

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http://link.springer.com/10.1007/s00109-018-1712-z
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http://dx.doi.org/10.1007/s00109-018-1712-zDOI Listing
January 2019
7 Reads

Hypoxia-inducible factor-1α regulation of myeloid cells.

J Mol Med (Berl) 2018 Dec 1;96(12):1293-1306. Epub 2018 Nov 1.

Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Hematopoietic myeloblasts give rise to macrophages, dendritic cells, and neutrophils. Circulating myeloid cells detect invading microbes using pattern recognition receptors and subsequently orchestrate an innate immune response to contain and kill the pathogens. This innate immune response establishes an inflammatory niche characterized by hypoxia due to host and pathogen factors. Read More

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http://link.springer.com/10.1007/s00109-018-1710-1
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http://dx.doi.org/10.1007/s00109-018-1710-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292431PMC
December 2018
6 Reads

Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity.

J Mol Med (Berl) 2018 Dec 1;96(12):1279-1292. Epub 2018 Nov 1.

University Medical Center of the Johannes Gutenberg-Universität Mainz, Mainz, Germany.

Autoreactive T cells are considered the major culprits in the pathogenesis of many autoimmune diseases like multiple sclerosis (MS). Upon activation in the lymphoid organs, autoreactive T cells migrate towards the central nervous system (CNS) and target the myelin sheath-forming oligodendrocytes, resulting in detrimental neurological symptoms. Despite the availability of extensively studied systems like the experimental autoimmune encephalomyelitis (EAE) model, our understanding of this disease and the underlying pathogenesis is still elusive. Read More

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http://link.springer.com/10.1007/s00109-018-1709-7
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http://dx.doi.org/10.1007/s00109-018-1709-7DOI Listing
December 2018
9 Reads

Pre-treatment with angiotensin-(1-7) inhibits tumor growth via autophagy by downregulating PI3K/Akt/mTOR signaling in human nasopharyngeal carcinoma xenografts.

J Mol Med (Berl) 2018 Dec 29;96(12):1407-1418. Epub 2018 Oct 29.

Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Song District, Kaohsiung, 833, Taiwan.

The highest incidence of nasopharyngeal carcinoma (NPC) is in southeast China, including Taiwan. Many side effects have been observed following radiation therapy with chemotherapy; hence, exploring new treatment modalities for NPC is an important future direction. Angiotensin-(1-7) [Ang-(1-7)] is an endogenous heptapeptide hormone and important component of the renin-angiotensin system that acts through both the Mas receptor and AT2 receptor, exhibiting anti-proliferative and anti-angiogenic properties in cancer cells. Read More

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http://link.springer.com/10.1007/s00109-018-1704-z
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http://dx.doi.org/10.1007/s00109-018-1704-zDOI Listing
December 2018
10 Reads

Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species.

J Mol Med (Berl) 2018 Dec 25;96(12):1395-1405. Epub 2018 Oct 25.

Institute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, D-69120, Heidelberg, Germany.

Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain largely unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of reactive oxygen species (ROS) have gained attention as possible mechanisms of organ damage in diabetes. Read More

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http://link.springer.com/10.1007/s00109-018-1707-9
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http://dx.doi.org/10.1007/s00109-018-1707-9DOI Listing
December 2018
7 Reads

Thymus-derived Foxp3 regulatory T cells upregulate RORγt expression under inflammatory conditions.

J Mol Med (Berl) 2018 Dec 24;96(12):1387-1394. Epub 2018 Oct 24.

Department Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany.

Foxp3 regulatory T cells (Tregs) co-expressing the Th17-lineage specification factor RORγt represent a unique Treg subpopulation that has been reported to be induced upon response to gut microbiota within the intestinal immune system. Hence, RORγt Tregs are considered to solely consist of peripherally induced Foxp3 Tregs (pTregs), and the possibility that also thymus-derived Treg (tTregs) can upregulate RORγt expression and contribute to the pool of RORγt Tregs was largely ignored. Here, we expand our knowledge on the origin of RORγt Tregs by demonstrating that also tTregs can attain RORγt expression. Read More

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http://link.springer.com/10.1007/s00109-018-1706-x
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http://dx.doi.org/10.1007/s00109-018-1706-xDOI Listing
December 2018
3 Reads

Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease.

J Mol Med (Berl) 2018 Dec 23;96(12):1375-1385. Epub 2018 Oct 23.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Ave, Boston, MA, 02115, USA.

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and long-term oxygen therapy has been shown to reduce mortality in COPD patients with severe hypoxemia. However, the Long-term Oxygen Treatment Trial (LOTT), a large randomized trial, found no benefit of oxygen therapy in COPD patients with moderate hypoxemia. We hypothesized that there may be differences in response to oxygen which depend on genotype or gene expression. Read More

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http://link.springer.com/10.1007/s00109-018-1708-8
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http://dx.doi.org/10.1007/s00109-018-1708-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240374PMC
December 2018
17 Reads

Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease.

J Mol Med (Berl) 2018 Dec 20;96(12):1359-1373. Epub 2018 Oct 20.

Department of Orthopaedic Surgery, New York University Medical Center, 301 East 17th Street, New York, NY, 10003, USA.

Tay-Sachs disease (TSD) is a lethal lysosomal storage disease (LSD) caused by mutations in the HexA gene, which can lead to deficiency of β-hexosaminidase A (HexA) activity and consequent accumulation of its substrate, GM2 ganglioside. Recent reports that progranulin (PGRN) functions as a chaperone of lysosomal enzymes and its deficiency is associated with LSDs, including Gaucher disease and neuronal ceroid lipofuscinosis, prompted us to screen the effects of recombinant PGRN on lysosomal storage in fibroblasts from 11 patients affected by various LSDs, which led to the isolation of TSD in which PGRN demonstrated the best effects in reducing lysosomal storage. Subsequent in vivo studies revealed significant GM2 accumulation and the existence of typical TSD cells containing zebra bodies in both aged and ovalbumin-challenged adult PGRN-deficient mice. Read More

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http://dx.doi.org/10.1007/s00109-018-1703-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240367PMC
December 2018
2 Reads

AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload.

J Mol Med (Berl) 2018 Dec 19;96(12):1345-1357. Epub 2018 Oct 19.

Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, People's Republic of China.

AdipoRon, a small-molecule adiponectin receptor (AdipoR) agonist, has been reported to be implicated in cardiovascular diseases. However, its role in pressure-overload-induced cardiac remodeling is still elusive. To elucidate the role of AdipoRon in the pathogenesis of cardiac remodeling in vivo and vitro, in the left ventricle of human end-stage heart failure, the expression of AdipoR2 is upregulated. Read More

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http://dx.doi.org/10.1007/s00109-018-1696-8DOI Listing
December 2018
5.110 Impact Factor

Plasminogen/thrombomodulin signaling enhances VEGF expression to promote cutaneous wound healing.

J Mol Med (Berl) 2018 Dec 19;96(12):1333-1344. Epub 2018 Oct 19.

Cardiovascular Research Center, National Cheng Kung University, Tainan, Taiwan.

Plasminogen (Plg) and thrombomodulin (TM) are glycoproteins well known for fibrinolytic and anticoagulant functions, respectively. Both Plg and TM are essential for wound healing. However, their significance during the reparative process was separately demonstrated in previous studies. Read More

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http://dx.doi.org/10.1007/s00109-018-1702-1DOI Listing
December 2018
1 Read

TRIB2 regulates the differentiation of MLL-TET1 transduced myeloid progenitor cells.

J Mol Med (Berl) 2018 Nov 15;96(11):1267-1277. Epub 2018 Oct 15.

School of Life Science, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea.

The function and mechanism of action of MLL-TET1 (MT1) fusion protein in hematological cells are unclear and require further investigation. In the present study, we found that the MT1 fusion protein attenuated the expression of Cebpa, Csf1r, and Cd11b and inhibited the differentiation of myeloid progenitor cells. Increased binding of the MT1 fusion protein to the Trib2 promoter upregulated Trib2 mRNA and protein expression and downregulated Cebpa expression. Read More

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http://link.springer.com/10.1007/s00109-018-1700-3
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http://dx.doi.org/10.1007/s00109-018-1700-3DOI Listing
November 2018
17 Reads

Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke.

J Mol Med (Berl) 2018 Dec 13;96(12):1319-1332. Epub 2018 Oct 13.

Faculty of Biology, Medicine and Health, AV Hill Building, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Restoration of cerebral blood flow (CBF) and upregulation of angiogenesis are crucial for brain repair and functional recovery after cerebral ischaemia. Pentraxin 3 (PTX3) is a key regulator of angiogenesis and is emerging as a promising target for cerebrovascular repair after stroke. Here, we investigated for the first time the role of PTX3 in long-term CBF, angiogenesis, and neuronal viability after ischaemic stroke induced by transient middle cerebral artery occlusion (MCAo). Read More

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http://link.springer.com/10.1007/s00109-018-1698-6
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http://dx.doi.org/10.1007/s00109-018-1698-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245246PMC
December 2018
14 Reads
5.110 Impact Factor