939 results match your criteria Journal of Molecular Histology [Journal]


Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model.

J Mol Histol 2019 Apr 23. Epub 2019 Apr 23.

Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.

Oxidative stress with mitochondrial defects has a central role in the development and deterioration of Multiple sclerosis (MS). According to new findings of the effects of metformin on mitochondrial function, has attracted a lot of attention. Furthermore, it is suggested that metformin exerts its beneficial influence through AMP-activated protein kinase (AMPK) pathway. Read More

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http://dx.doi.org/10.1007/s10735-019-09824-0DOI Listing

Rilpivirine as a potential candidate for the treatment of HIV-associated neurocognitive disorders (HAND).

J Mol Histol 2019 Apr 22. Epub 2019 Apr 22.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, E-block, 6th floor, Room E1-06-016, Durban, South Africa.

As the HIV epidemic continues to contribute to global morbidity and mortality, the prevalence of HIV-associated neurological disorders (HAND) also continues to be a major concern in infected individuals, despite the widespread use of combination antiretroviral therapy. Therefore, current antiretroviral drugs should be able to reach therapeutic levels in the brain for the treatment of HAND. The brain distribution of the next-generation non-nucleoside reverse transcriptase inhibitor, rilpivirine (RPV) was investigated in healthy female Sprague-Dawley (SD) rats. Read More

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http://link.springer.com/10.1007/s10735-019-09826-y
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http://dx.doi.org/10.1007/s10735-019-09826-yDOI Listing
April 2019
1 Read

Type XI collagen-perlecan-HS interactions stabilise the pericellular matrix of annulus fibrosus cells and chondrocytes providing matrix stabilisation and homeostasis.

J Mol Histol 2019 Apr 16. Epub 2019 Apr 16.

Raymond Purves Bone and Joint Research Laboratories, Level 10, Kolling Institute of Medical Research B6, The Royal North Shore Hospital, St. Leonards, NSW, 2065, Australia.

The aim of this study was to ascertain whether, like many cell types in cartilaginous tissues if type XI collagen was a pericellular component of annulus fibrosus (AF) cells and chondrocytes. Fine fibrillar networks were visualised which were perlecan, HS (MAb 10E4) and type XI collagen positive. Heparitinase-III pre-digestion abolished the type XI collagen and 10E4 localisation in these fibrillar assemblies demonstrating a putative HS mediated interaction which localised the type XI collagen. Read More

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http://dx.doi.org/10.1007/s10735-019-09823-1DOI Listing

Effects of Nel-like molecule-1 and bone morphogenetic protein 2 combination on rat pulp repair.

J Mol Histol 2019 Apr 1. Epub 2019 Apr 1.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, Shandong, China.

Nel-like molecule-1 (NELL-1) is a novel highly specific growth factor that can induce osteoblast differentiation and bone formation as well as odontoblast differentiation. Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and inhibit adverse effects induced by BMP2. This study aimed to evaluate the combined effects of NELL-1 and BMP2 on rat pulp repair. Read More

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http://dx.doi.org/10.1007/s10735-019-09822-2DOI Listing
April 2019
2 Reads

Changes in mechanoreceptors in rabbits' anterior cruciate ligaments with age.

J Mol Histol 2019 Mar 29. Epub 2019 Mar 29.

Department of Histology and Embryology, College of Basic Medical Sciences, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

At present, a few studies have been done on the changes in the distribution, morphology and quantity of mechanoreceptors in anterior cruciate ligament (ACL) with age. In this study, we observed the changes in mechanoreceptors of healthy rabbits' ACL with age. We found that rabbits' ACLs contained 5 kinds of mechanoreceptors including Ruffini corpuscles, Pacinian corpuscles, Golgitendon bodies, free nerve endings and atypical mechanoreceptors. Read More

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http://dx.doi.org/10.1007/s10735-019-09820-4DOI Listing
March 2019
1 Read

Distribution of sperm antigen 6 (SPAG6) and 16 (SPAG16) in mouse ciliated and non-ciliated tissues.

J Mol Histol 2019 Mar 25. Epub 2019 Mar 25.

Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Gral. Flores 2125, Montevideo, Uruguay.

The cilia and flagella of eukaryotic cells serve many functions, exhibiting remarkable conservation of both structure and molecular composition in widely divergent eukaryotic organisms. SPAG6 and SPAG16 are the homologous in the mice to Chlamydomonas reinhardtii PF16 and PF20. Both proteins are associated with the axonemal central apparatus and are essential for ciliary and flagellar motility in mammals. Read More

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http://dx.doi.org/10.1007/s10735-019-09817-zDOI Listing
March 2019
1 Read

Quantitative changes in perineuronal nets in development and posttraumatic condition.

J Mol Histol 2019 Mar 22. Epub 2019 Mar 22.

Neuroscience Center, University of Helsinki, Viikinkaari 4, P.O.Box 56, 00790, Helsinki, Finland.

Perineuronal net (PNN) is a highly structured portion of the CNS extracellular matrix (ECM) regulating synaptic plasticity and a range of pathologic conditions including posttraumatic regeneration and epilepsy. Here we studied Wisteria floribunda agglutinin-stained histological sections to quantify the PNN size and enrichment of chondroitin sulfates in mouse brain and spinal cord. Somatosensory cortex sections were examined during the period of PNN establishment at postnatal days 14, 21 and 28. Read More

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http://dx.doi.org/10.1007/s10735-019-09818-yDOI Listing

Expression patterns of genes critical for SHH, BMP, and FGF pathways during the lumen formation of human salivary glands.

J Mol Histol 2019 Mar 20. Epub 2019 Mar 20.

Fujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou, 350108, Fujian, People's Republic of China.

Sjögren's syndrome or radiotherapy for head and neck cancer leads to the irreversible hypofunction of salivary gland (SG). The stem/progenitor cell-based regenerative strategy has been proven to be the most promising approach to repair the function of SG. The molecular mechanisms that regulate SG morphogenesis, especially during lumen formation, provide valuable hints for establishment of such regenerative strategies. Read More

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http://dx.doi.org/10.1007/s10735-019-09819-xDOI Listing
March 2019
1 Read

Expression of CPNE7 during mouse dentinogenesis.

J Mol Histol 2019 Mar 12. Epub 2019 Mar 12.

Laboratory for the Study of Regenerative Dental Medicine, Department of Oral Histology-Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, 1 Gwanakro, Gwanak-gu, Seoul, 08826, Republic of Korea.

Interactions between the ectodermal and mesenchymal tissues are the basis of the central mechanism regulating tooth development. Based on this epithelial-mesenchymal interaction (EMI), we demonstrated that copine-7 (CPNE7) is secreted by preameloblasts and regulates the differentiation of mesenchymal cells of dental or non-dental origin into odontoblasts. However, the precise expression patterns of CPNE7 in the stages of tooth development have not yet been elucidated. Read More

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http://dx.doi.org/10.1007/s10735-019-09816-0DOI Listing
March 2019
1.815 Impact Factor

MicroRNA-mediated regulation of BM-MSCs differentiation into sweat gland-like cells: targeting NF-κB.

J Mol Histol 2019 Apr 19;50(2):155-166. Epub 2019 Feb 19.

Molecular Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, 28 Fu Xing Road, Haidian District, Beijing, 100853, People's Republic of China.

Sweat gland regeneration is important for patients with an extensive deep burn injury. In previous study, we reported that bone marrow-mesenchymal stem cells (BM-MSCs) could differentiate into sweat gland-like cells (SGLCs), but the underlying molecular mechanism remains unclear. Recently, microRNAs (miRNAs or miRs) are reported to manipulate many biological processes. Read More

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http://dx.doi.org/10.1007/s10735-019-09814-2DOI Listing

Melatonin preconditioning of bone marrow-derived mesenchymal stem cells promotes their engraftment and improves renal regeneration in a rat model of chronic kidney disease.

J Mol Histol 2019 Apr 22;50(2):129-140. Epub 2019 Jan 22.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Bone marrow-derived mesenchymal stem cells (BMMSCs) transplantation has shown to be effective in treating chronic kidney disease. However, the effectiveness of this strategy is constrained by low homing and survival rate of transplanted cells in the injured organs. Therefore, developing strategies to improve homing and cell survival rate and therapeutic potential in cell-based therapies seems necessary. Read More

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http://link.springer.com/10.1007/s10735-019-09812-4
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http://dx.doi.org/10.1007/s10735-019-09812-4DOI Listing
April 2019
9 Reads
1.815 Impact Factor

The histone deacetylase class I, II inhibitor trichostatin A delays peripheral neurodegeneration.

J Mol Histol 2019 Apr 22;50(2):167-178. Epub 2019 Jan 22.

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea.

Peripheral nerves, which consist of an axon and a unique glial cell called a Schwann cell, transduce signals from the brain and spinal cord to target organs. Peripheral nerve degeneration leads to distal motor or sensory disorders such as diabetic neuropathy, Charcot-Marie-Tooth disease, and Gullain-Barré syndrome, with symptoms such as dysesthesia, speech impairment, vision change, erectile dysfunction, and urinary incontinence. Schwann cells play an important role in peripheral nerve degeneration. Read More

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http://dx.doi.org/10.1007/s10735-019-09815-1DOI Listing
April 2019
7 Reads

Site-specific expression of IQGAP1 in human nephrons.

J Mol Histol 2019 Apr 19;50(2):119-127. Epub 2019 Jan 19.

Department of Nephrology, Shandong Provincial Qianfoshan Hospital, Shandong University, No.16766, Jingshi Road, Jinan, 250014, China.

IQGAP1 is a multifunctional, 190-kDa scaffolding protein that plays an important role in the regulation of cell adhesion, migration, proliferation, differentiation, polarization and cytoskeletal remodeling. IQGAP1 is ubiquitously expressed in human organs and is highly expressed in the kidney. Currently, the site-specific expression of IQGAP1 in the human nephrons is unclear. Read More

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http://dx.doi.org/10.1007/s10735-019-09811-5DOI Listing
April 2019
2 Reads

Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis.

J Mol Histol 2019 Apr 18;50(2):141-154. Epub 2019 Jan 18.

Laboratory of Cell Biology, Ariel University, 40700, Ariel, Israel.

The sperm produced in the seminiferous tubules pass through the rete testis, efferent ducts, and epididymis. The epididymis has three distinct regions known as caput, corpus, and cauda. The transit through the epididymis is an essential process in sperm maturation. Read More

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http://dx.doi.org/10.1007/s10735-019-09813-3DOI Listing
April 2019
1 Read
1.815 Impact Factor

Osteogenic and angiogenic characterization of mandible and femur osteoblasts.

J Mol Histol 2019 Apr 11;50(2):105-117. Epub 2019 Jan 11.

Fujian Biological Materials Engineering and Technology Center of Stomatology, School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Rd, Fuzhou, 350002, Fujian, China.

Craniofacial autologous bone grafts offer superior outcomes to long bone grafts in the reconstruction of maxillofacial bone defects, but the mechanism responsible for this superiority has not yet been illustrated clearly. Osteoblasts play vital roles in bone development and regeneration. However, presently, only a few studies have compared the osteogenic ability of osteoblasts from craniofacial and long bones, and the results are contradictory. Read More

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http://dx.doi.org/10.1007/s10735-019-09810-6DOI Listing
April 2019
2 Reads

Sepsis-related myocardial injury is associated with Mst1 upregulation, mitochondrial dysfunction and the Drp1/F-actin signaling pathway.

J Mol Histol 2019 Apr 2;50(2):91-103. Epub 2019 Jan 2.

Department of Critical Care Medicine, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine, Fujian Medical University, Fuzhou, 350001, Fujian, China.

LPS-induced septic cardiomyopathy has been found to be connected with mitochondrial stress through unknown mechanisms. Mitochondrial fission is an early event in mitochondrial dysfunction. The aim of our study was to determine the role and regulatory mechanism of mitochondrial fission in the progression of LPS-induced septic cardiomyopathy, with a particular focus on Mst1 and F-actin. Read More

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http://dx.doi.org/10.1007/s10735-018-09809-5DOI Listing
April 2019
1 Read
1.815 Impact Factor

Autophagy promotes hepatic differentiation of hepatic progenitor cells by regulating the Wnt/β-catenin signaling pathway.

J Mol Histol 2019 Feb 2;50(1):75-90. Epub 2019 Jan 2.

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.

Hepatic progenitor cells (HPCs) can be activated when the liver suffers persistent and severe damage and can differentiate into hepatocytes to maintain liver regeneration and homeostasis. However, the molecular mechanism underlying the hepatic differentiation of HPCs is unclear. Therefore, in this study, we aimed to investigate the roles of autophagy and the Wnt/β-catenin signaling pathway during hepatic differentiation of HPCs in vivo and in vitro. Read More

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http://dx.doi.org/10.1007/s10735-018-9808-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323068PMC
February 2019
4 Reads

Subcellular localization of sterol biosynthesis enzymes.

J Mol Histol 2019 Feb 8;50(1):63-73. Epub 2018 Dec 8.

Department of Psychiatry and Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.

Cholesterol synthesis is a complex, coordinated process involving a series of enzymes. As of today, our understanding of subcellular localization of cholesterol biosynthesis enzymes is far from complete. Considering the complexity and intricacies of this pathway and the importance of functions of DHCR7, DHCR24 and EBP enzymes for human health, we undertook a study to determine their subcellular localization and co-localization. Read More

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http://dx.doi.org/10.1007/s10735-018-9807-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467513PMC
February 2019
2 Reads

Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.

J Mol Histol 2019 Feb 5;50(1):43-61. Epub 2018 Dec 5.

Department of Oral Pathology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, China.

Dentin is a major component of teeth that protects dental pulp and maintains tooth health. Bone morphogenetic protein (BMP) signaling is required for the formation of dentin. Mice lacking a BMP type I receptor, activin A receptor type 1 (ACVR1), in the neural crest display a deformed mandible. Read More

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http://link.springer.com/10.1007/s10735-018-9806-z
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http://dx.doi.org/10.1007/s10735-018-9806-zDOI Listing
February 2019
17 Reads

Periodontal ligament-associated protein-1 gets involved in the development of osseous eruption canal.

J Mol Histol 2019 Feb 3;50(1):35-42. Epub 2018 Dec 3.

Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, People's Republic of China.

Osseous eruption is an important stage of tooth eruption process. The role of periodontal ligament-associated protein-1 (PLAP-1/asporin) in the development of osseous eruption canal remain undefined and were the focus of this study. C57BL/6 mice at postnatal days P11-13 and P 15-16 were chosen. Read More

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http://link.springer.com/10.1007/s10735-018-9805-0
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http://dx.doi.org/10.1007/s10735-018-9805-0DOI Listing
February 2019
12 Reads

The inhibition of glycosaminoglycan incorporation influences the cell proliferation and cytodifferentiation in cultured embryonic mouse molars.

J Mol Histol 2019 Feb 29;50(1):11-19. Epub 2018 Nov 29.

Department of Operative Dentistry and Endodontics, School & Hosipital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, 399 Middle Yan Chang Road, Shanghai, 200072, China.

The extracellular matrix (ECM) contains a variety of complex macromolecules including proteoglycans (PGs) and glycosaminoglycans (GAGs). PG consists of a protein core with covalently attached carbohydrate side chains called GAGs. Several PGs, including versican, biglycan, decorin and syndecan are involved in odontogenesis while the role of GAGs in those PGs in this process remains unclarified. Read More

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http://dx.doi.org/10.1007/s10735-018-9803-2DOI Listing
February 2019
2 Reads

Hormonal control of vas deferens fluid volume and aquaporin expression in rats.

J Mol Histol 2019 Feb 14;50(1):21-34. Epub 2018 Nov 14.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Lembah Pantai, Kuala Lumpur, Malaysia.

Precise regulation of vas deferens fluid volume which is important for sperm survival might be influenced by testosterone. In order to investigate changes in vas deferens fluid volume and aquoporins (AQP) isoforms expression under testosterone influence, orchidectomized Sprague-Dawley rats were given 125 and 250 µg/kg/day testosterone with or without flutamide, an androgen receptor blocker or finasteride, a 5alpha-reductase inhibitor for seven consecutive days. Following treatment completion, vas deferens was perfused and changes in the fluid secretion rate and osmolality were determined in the presence of acetazolamide. Read More

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http://link.springer.com/10.1007/s10735-018-9804-1
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http://dx.doi.org/10.1007/s10735-018-9804-1DOI Listing
February 2019
16 Reads

Discrimination of normal oral mucosa from oral cancer by mass spectrometry imaging of proteins and lipids.

J Mol Histol 2019 Feb 3;50(1):1-10. Epub 2018 Nov 3.

Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute - Oncology Center Gliwice Branch, ul. Wybrzeze Armii Krajowej 15, 44-101, Gliwice, Poland.

Identification of biomarkers for molecular classification of cancer and for differentiation between cancerous and normal epithelium remains a vital issue in the field of head and neck cancer. Here we aimed to compare the ability of proteome and lipidome components to discriminate oral cancer from normal mucosa. Tissue specimens including squamous cell cancer and normal epithelium were analyzed by MALDI mass spectrometry imaging. Read More

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http://link.springer.com/10.1007/s10735-018-9802-3
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http://dx.doi.org/10.1007/s10735-018-9802-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323087PMC
February 2019
5 Reads

Favorable outcomes of metformin on coronary microvasculature in experimental diabetic cardiomyopathy.

J Mol Histol 2018 Dec 13;49(6):639-649. Epub 2018 Oct 13.

Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, P.O. 35516, Mansoura, Egypt.

Although metformin is widely prescribed in diabetes, its use with associated cardiac dysfunction remains debatable. In the current study, we investigated the effect of metformin on coronary microvasculature in experimental diabetic cardiomyopathy (DCM) induced by streptozotocin. Administration of metformin after induction of DCM, reversed almost all cardiomyocyte degenerative changes induced by DCM. Read More

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http://dx.doi.org/10.1007/s10735-018-9801-4DOI Listing
December 2018
2 Reads
1.820 Impact Factor

Electron microscopic study of Golgi-impregnated and gold-toned neurons and fibers in the claustrum of the cat.

J Mol Histol 2018 Dec 10;49(6):615-630. Epub 2018 Oct 10.

Department of Anatomy, Histology and Embryology, Medical University of Sofia, 2 Zdrave St, 1431, Sofia, Bulgaria.

The claustrum is a subcortical nucleus found in the telencephalon of all placental mammals. It is a symmetrical, thin and irregular sheet of grey matter which lies between the inner surface of the insular cortex and the outer surface of the putamen. The claustrum has extensive connections with the visual, auditory, somatosensory and motor regions of the cortex, as well as with subcortical and allocortical regions. Read More

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http://dx.doi.org/10.1007/s10735-018-9799-7DOI Listing
December 2018
1 Read
1.820 Impact Factor

First ovarian response to gonadotrophin stimulation in rats exposed to neonatal androgen excess.

J Mol Histol 2018 Dec 9;49(6):631-637. Epub 2018 Oct 9.

Histology and Embryology Department, School of Medicine, UdelaR, General Flores 2125, CP 11800, Montevideo, Uruguay.

This study analyzes the effects of neonatal androgenization on follicular growth and first ovulation in response to gonadotrophins, using a model of exogenous stimulation or the use of subcutaneous ovary grafts in castrated animals to replace the hypothalamus-pituitary signal. Neonatal rats (days 1-5) were treated with testosterone, dihydrotestosterone or vehicle. At juvenile period, rats were stimulated with PMSG, hCG (alone or combined) or used as ovarian donors to be grafted on castrated adult female rats. Read More

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http://dx.doi.org/10.1007/s10735-018-9800-5DOI Listing
December 2018
5 Reads

Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation.

J Mol Histol 2018 Dec 8;49(6):599-613. Epub 2018 Oct 8.

Department of Neurosurgery, PLA Army General Hospital, No. 5 Nanmencang Hutong, Dongcheng District, Beijing, 100730, China.

Mitochondrial fragmentation drastically regulates mitochondrial homeostasis in brain illness. However, the role of mitochondrial fragmentation in cerebral ischemia-reperfusion (IR) injury remains unclear. Nur77, a regulator of mitochondrial homeostasis, is associated with heart and liver IR injury, but its effects on mitochondrial function in cerebral IR injury has not been studied intensively. Read More

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http://link.springer.com/10.1007/s10735-018-9798-8
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http://dx.doi.org/10.1007/s10735-018-9798-8DOI Listing
December 2018
17 Reads

Decreased autophagy was implicated in the decreased apoptosis during decidualization in early pregnant mice.

J Mol Histol 2018 Dec 8;49(6):589-597. Epub 2018 Oct 8.

Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Box 197, Chongqing, 400016, People's Republic of China.

Folate deficiency is a major risk factor of birth defects. Mechanistic studies on folate deficiency resulting in birth defects have mainly focused on fetal development. There have been few studies on folate deficiency from the point of view of the mother's uterus. Read More

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http://dx.doi.org/10.1007/s10735-018-9797-9DOI Listing
December 2018
6 Reads
1.820 Impact Factor

Mechanism of fibrogenesis in submandibular glands in patients with IgG4-RD.

J Mol Histol 2018 Dec 24;49(6):577-587. Epub 2018 Sep 24.

Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan.

The aim of this study was to investigate the mechanisms driving fibrosis in the submandibular glands (SMG) of patients with IgG4-related disease (IgG4-RD). Immunohistochemistry showed that many fibroblast-like cells expressing IL-6, IL-18, TSLP, IL-33, and MMP1 were present in SMG from the affected patients. SMG fibroblasts were derived from patients with or without IgG4-RD and were cultured in vitro. Read More

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http://link.springer.com/10.1007/s10735-018-9796-x
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http://dx.doi.org/10.1007/s10735-018-9796-xDOI Listing
December 2018
8 Reads

Time course of differentiation of different cell types in 3D-reconstructed eccrine sweat glands.

J Mol Histol 2018 Dec 20;49(6):567-575. Epub 2018 Sep 20.

Department of Burn and Plastic Surgery, The Second Affiliated Hospital, Shantou University Medical College, North Dongxia Road, Shantou, 515041, Guangdong, China.

Epidermal basal cells invaginate into the dermis to form sweat ducts, which then grow downwards further to form secretory coils during the ontogenesis of eccrine sweat glands, but the time course of differentiation of different cell types in 3D-reconstructed eccrine sweat glands remain unclear. In this study, secretory cell-specific marker K7, clear secretory cell-specific marker CA II, dark secretory cell-specific marker GCDFP-15, myoepithelial cell-specific marker α-SMA, inner duct cell-specific marker S100P and outer duct cell-specific marker S100A2 were detected by immunofluorescence staining. The results showed that S100P and S100A2 were first detected at 2 weeks post implantation, K7 and α-SMA at 3 weeks, and GCDFP-15 and CA II at 4 weeks. Read More

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http://dx.doi.org/10.1007/s10735-018-9795-yDOI Listing
December 2018
2 Reads

Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction.

J Mol Histol 2018 Dec 17;49(6):555-565. Epub 2018 Sep 17.

Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, People's Republic of China.

Interstitial fibrosis after acute myocardial infarction (MI) leads to cardiac structural remodeling and dysfunction. The peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist chrysin has been shown to protect injured myocardium through suppression of oxidative stress and inflammation. This study was designed to investigate the effect and mechanism of chrysin on myocardial fibrosis. Read More

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http://dx.doi.org/10.1007/s10735-018-9793-0DOI Listing
December 2018
11 Reads

Assessment of the cellular localisation of the annexin A2/S100A10 complex in human placenta.

J Mol Histol 2018 Oct 24;49(5):531-543. Epub 2018 Aug 24.

School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.

The AnxA2/S100A10 complex has been implicated in various placental functions but although the localisation of these proteins individually has been studied, there is no information about the localisation of their complex in situ at the cellular level. Using the proximity ligation technique, we have investigated the in situ localisation of AnxA2/S100A10 complex in the placenta and have compared this with the location patterns of the individual proteins. High levels of expression of AnxA2/S100A10 complexes were observed in the amniotic membrane and in blood vessel endothelial cells. Read More

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http://dx.doi.org/10.1007/s10735-018-9791-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182581PMC
October 2018
18 Reads

Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination.

J Mol Histol 2018 Oct 24;49(5):471-479. Epub 2018 Aug 24.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poursina Street, 1417613151, Tehran, Iran.

Glucocorticoids (GC) are known as inflammatory drugs, which are used in neuroinflammatory diseases. Unlike the classic picture, recent studies have revealed that some GC drugs exacerbate inflammatory responses in their acute and prolonged administration. Multiple sclerosis (MS) is a demyelinating inflammatory disorder, in which reactive M1 microglia phenotype play a central role. Read More

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http://link.springer.com/10.1007/s10735-018-9786-z
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http://dx.doi.org/10.1007/s10735-018-9786-zDOI Listing
October 2018
10 Reads

Further studies about Coactosin-like protein-1 affecting the migration of mouse neocortical neurons.

J Mol Histol 2018 Oct 20;49(5):519-530. Epub 2018 Aug 20.

College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.

During the development of mammalian cortex, late neurons generated by neuronal progenitors bypass earlier-born neurons and migrate to reach upper layers of cortical plate in an inner-to-outer fashion. Filamentous-actin (F-actin) can regulate neuronal migration, whereas Coactosin-like protein 1 (Cotl1) modulates F-actin. Lys 75 and Arg 73 of Cotl1 play an important role in binding F-actin; when they are mutated to Glu, Cotl1 cannot bind F-actin, called as a non-actin-binding mutant (ABM). Read More

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http://dx.doi.org/10.1007/s10735-018-9790-3DOI Listing
October 2018
2 Reads

NLRP1 promotes TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts.

J Mol Histol 2018 Oct 18;49(5):509-518. Epub 2018 Aug 18.

Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, People's Republic of China.

Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a member of Nod-like receptors (NLRs) family. Recent studies have reported that NLRP1 is involved in various diseases, especially in cardiovascular diseases. However, the effect of NLRP1 on cardiac fibrosis remains unclear. Read More

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http://dx.doi.org/10.1007/s10735-018-9789-9DOI Listing
October 2018
8 Reads
1.820 Impact Factor

Expression of BMP2/4/7 during the odontogenesis of deciduous molars in miniature pig embryos.

J Mol Histol 2018 Oct 11;49(5):545-553. Epub 2018 Aug 11.

Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Tian Tan Xi Li No.4, Beijing, 100050, China.

Bone morphogenetic proteins (BMPs) play important roles in tooth development. However, their expression has not been studied in miniature pigs, which have many anatomical similarities in oral and maxillofacial region compared to human. This study investigated BMP2/4/7 expression patterns during deciduous molar development in miniature pigs on embryonic days (E) 40, 50, and 60. Read More

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http://dx.doi.org/10.1007/s10735-018-9792-1DOI Listing
October 2018
20 Reads

Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization.

J Mol Histol 2018 Oct 31;49(5):499-507. Epub 2018 Jul 31.

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

Enamel is the hardest tissue with the highest degree of mineralization protecting the dental pulp from injury in vertebrates. The ameloblasts differentiated from ectoderm-derived epithelial cells are a single cell layer and are important for the enamel formation and mineralization. Wnt/β-catenin signaling has been proven to exert an important role in the mineralization of bone, dentin and cementum. Read More

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http://link.springer.com/10.1007/s10735-018-9788-x
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http://dx.doi.org/10.1007/s10735-018-9788-xDOI Listing
October 2018
14 Reads
1.820 Impact Factor

Cysteine cathepsins B, X and K expression in peri-arteriolar glioblastoma stem cell niches.

J Mol Histol 2018 Oct 25;49(5):481-497. Epub 2018 Jul 25.

Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, 1000, Ljubljana, Slovenia.

Glioblastoma (GBM) is the most lethal brain tumor also due to malignant and therapy-resistant GBM stem cells (GSCs) that are localized in protecting hypoxic GSC niches. Some members of the cysteine cathepsin family of proteases have been found to be upregulated in GBM. Cathepsin K gene expression is highly elevated in GBM tissue versus normal brain and it has been suggested to regulate GSC migration out of the niches. Read More

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http://dx.doi.org/10.1007/s10735-018-9787-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182580PMC
October 2018
5 Reads

Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition.

J Mol Histol 2018 Oct 16;49(5):459-469. Epub 2018 Jul 16.

Department of Stomatology, Second Xiangya Hospital, Renmin Middle Road, Changsha, 410011, Hunan, China.

Cdkn1c, a member of the Cip/Kip cyclin-dependent kinase inhibitor family, is critically involved in regulating cell cycle and cellular differentiation during development in mammals. However, the functional role of Cdkn1c and the underlying mechanisms by which Cdkn1c affects odontogenesis remain largely unknown. In our study, we found that Cdkn1c expression dynamically changes from embryonic day 11. Read More

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http://dx.doi.org/10.1007/s10735-018-9785-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182578PMC
October 2018
15 Reads
1.820 Impact Factor

AhR activation protects intestinal epithelial barrier function through regulation of Par-6.

J Mol Histol 2018 Oct 10;49(5):449-458. Epub 2018 Jul 10.

Department of General Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.

The Par complex (Par-6/Par-3/aPKC) plays a key role in the maintenance of the intestinal barrier function through the regulation of epithelial junction formation. The aryl hydrocarbon receptor (AhR) has been shown to be an important regulator for intestinal homeostasis. In this study, we investigated the role of the AhR activation on the regulation of Par complex. Read More

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http://dx.doi.org/10.1007/s10735-018-9784-1DOI Listing
October 2018
30 Reads

MiR-146b protect against sepsis induced mice myocardial injury through inhibition of Notch1.

Authors:
Xinhua Wang Yuan Yu

J Mol Histol 2018 Aug 27;49(4):411-417. Epub 2018 Jun 27.

Ankang Central Hospital of Shaanxi, No.85 Jinzhou South Road, Ankang, 725000, Shaanxi, China.

Myocardial dysfunction is a major cause of death in sepsis. MicroRNA-146b (miR-146b) has been reported to be related to myocardial disease. However, the role of miR-146b in sepsis as well as myocardial injury is still unclear. Read More

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http://dx.doi.org/10.1007/s10735-018-9781-4DOI Listing
August 2018
3 Reads

Correction to: BrdU/EdU dual labeling to determine the cell-cycle dynamics of defined cellular subpopulations.

J Mol Histol 2018 Aug;49(4):447

The School of Biomedical Sciences, The Faculty of Medicine, The University of Queensland, Brisbane, 4072, Australia.

In the original publication of the article, two errors were made in describing the equations for T. Read More

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http://dx.doi.org/10.1007/s10735-018-9783-2DOI Listing
August 2018
1 Read

Cellular and subcellular localization of uncoupling protein 2 in the human kidney.

J Mol Histol 2018 Aug 23;49(4):437-445. Epub 2018 Jun 23.

Department of Health Sciences, University of Molise, Campobasso, Italy.

The uncoupling protein-2 (UCP2) is an anion transporter that plays a key role in the control of intracellular oxidative stress. In animal models UCP2 downregulation has several pathological sequelae, particularly affecting the vasculature and the kidney. Specifically, in these models kidney damage is highly favored in the absence of UCP2 in the context of experimental hypertension. Read More

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http://dx.doi.org/10.1007/s10735-018-9782-3DOI Listing
August 2018
31 Reads

Cell type specific expression of Follistatin-like 1 (Fstl1) in mouse embryonic lung development.

J Mol Histol 2018 Aug 18;49(4):399-409. Epub 2018 Jun 18.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China.

Follistatin like-1 (Fstl1) is a secreted glycoprotein and can be up-regulated by TGF-β1. To better study the function of Fstl1 in lung development, we examined Fstl1 expression in the developing lung, in a cell type specific manner, using a tamoxifen inducible Fstl1-reporter mouse strain. Our results show that Fstl1 is ubiquitously expressed at saccular stage in the developing lung. Read More

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http://dx.doi.org/10.1007/s10735-018-9780-5DOI Listing
August 2018
6 Reads

CGRP gene-modified rBMSCs show better osteogenic differentiation capacity in vitro.

J Mol Histol 2018 Aug 30;49(4):357-367. Epub 2018 May 30.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Periodontology, School and Hospital of Stomatology, Shandong University, 44-1 West Wenhua Road, Jinan, 250012, Shandong, People's Republic of China.

Calcitonin gene-related peptide (CGRP) is a marked and important neuropeptide expressed in nerve fibers during bone repair. This study investigated the role of CGRP overexpression on osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs). rBMSCs were infected with viral stocks of pLenO-DCE-CGRP (CGRP group) or pLenO-DCE (Vector group), while normal rBMSCs were used as a control. Read More

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http://dx.doi.org/10.1007/s10735-018-9775-2DOI Listing
August 2018
7 Reads

Over-expression of IQGAP1 indicates poor prognosis in head and neck squamous cell carcinoma.

J Mol Histol 2018 Aug 30;49(4):389-398. Epub 2018 May 30.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

IQ-domain GTPase-activating protein 1 (IQGAP1) is associated with the development and progression of many human cancers. We aimed to investigate the expression and clinicopathological significances of IQGAP1 in head and neck squamous cell carcinoma (HNSCC). In this study, immunohistochemical staining of IQGAP1, co-inhibitory immune checkpoint molecules and macrophage markers were performed in human HNSCC samples to analyze the expression and correlation with clinicopathological characteristics. Read More

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http://dx.doi.org/10.1007/s10735-018-9779-yDOI Listing
August 2018
4 Reads

miR-155 inhibits the formation of hypertrophic scar fibroblasts by targeting HIF-1α via PI3K/AKT pathway.

J Mol Histol 2018 Aug 21;49(4):377-387. Epub 2018 May 21.

Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Hypertrophic scar (HS) is a serious skin fibrotic disease characterized by the excessive proliferation of fibroblasts and often considered as a kind of benign skin tumor. microRNA-155 (miR-155) is usually served as a promising marker in antitumor therapy. In view of the similarities of hypertrophic scar and tumor, it is predicted that miR-155 may be a novel therapeutic target in clinical trials. Read More

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http://link.springer.com/10.1007/s10735-018-9778-z
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http://dx.doi.org/10.1007/s10735-018-9778-zDOI Listing
August 2018
22 Reads

Semaphorin 3A promotes osteogenic differentiation of BMSC from type 2 diabetes mellitus rats.

J Mol Histol 2018 Aug 17;49(4):369-376. Epub 2018 May 17.

School of Stomatology, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030012, China.

Bone regeneration is impaired in patients with type 2 diabetes mellitus (T2DM), which leads to non-healing after bone loss. The decreased osteogenic capacity of bone mesenchymal stem cells (BMSCs) might be a main reason. Sema3A, as a powerful protein promoting osteocyte differentiation, shows potential for bone regeneration treatment. Read More

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http://dx.doi.org/10.1007/s10735-018-9776-1DOI Listing
August 2018
3 Reads

VEGFA and VEGFR2 RNAscope determination in gastric cancer.

J Mol Histol 2018 Aug 14;49(4):429-435. Epub 2018 May 14.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico - Piazza G. Cesare, 11, 70124, Bari, Italy.

Gastric cancer is the fifth most common cancer and third leading cause of cancer-related death worldwide. Several studies on angiogenic blocking agents in gastric cancer revealing promising results by the use of monoclonal antibodies against VEGFA or its receptor VEGFR2 or against VEGFA activating pathway. The validation of biomarkers useful to better organize the clinical trials involving anti-angiogenic therapies is crucial. Read More

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http://dx.doi.org/10.1007/s10735-018-9777-0DOI Listing
August 2018
1 Read

Gamma-enolase predicts lung damage in severe acute pancreatitis-induced acute lung injury.

J Mol Histol 2018 Aug 4;49(4):347-356. Epub 2018 May 4.

Department of Biotechnology, Dalian Medical University, Dalian, 116044, Liaoning Province, China.

Severe acute pancreatitis (SAP) associated acute lung injury (ALI) accounts for about 70% mortality of SAP patients. However, there are no precise biomarkers for the disease currently. Herein, we evaluated the potential of gamma-enolase (ENO2), against its universal isoform alpha-enolase (ENO1), as a marker of SAP-ALI in a rat model. Read More

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http://dx.doi.org/10.1007/s10735-018-9774-3DOI Listing
August 2018
8 Reads