2,328 results match your criteria Journal of Molecular Endocrinology[Journal]


Molecular Mechanisms of FOXO1 in Adipocyte Differentiation.

J Mol Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

Q Huang, Key Provincial Laboratory of Basic Pharmacology, Nanchang University, Nanchang, China.

Forkhead box-O1 (FOXO1) is a downstream target of AKT and plays crucial roles in cell cycle control, apoptosis, metabolism and adipocyte differentiation. It is thought that FOXO1 affects adipocyte differentiation by regulating lipogenesis and cell cycle. With the deepening in the understanding of this field, it is currently believed that FOXO1 translocation between nucleus and cytoplasm is involved in the regulation of FOXO1 activity, thus affecting adipocyte differentiation. Read More

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http://dx.doi.org/10.1530/JME-18-0178DOI Listing
February 2019

The role and possible mechanism of lncRNA AC092159.2 in modulating adipocyte differentiation.

J Mol Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

J Wen, Nanjing Maternity and Child Health Care Institute, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing, China.

Obesity is a major risk factor for metabolic diseases, while adipocyte differentiation is closely related to obesity occurrence. Long noncoding RNAs (lncRNAs) are a unique class of transcripts in regulation of various biological processes. Using lncRNA microarray, we found lncRNA AC092159. Read More

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http://dx.doi.org/10.1530/JME-18-0215DOI Listing
February 2019

Systematic alanine scanning of PAX8 paired domain reveals functional importance of the N-subdomain.

J Mol Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

S Narumi, Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Japan.

Thyroid-specific transcription factor PAX8 has an indispensable role in the thyroid gland development, which is evidenced by the facts that PAX8/Pax8 mutations cause congenital hypothyroidism in humans and mice. More than 90% of known PAX8 mutations were located in the paired domain, suggesting the central role of the domain in exerting the molecular function. Structure-function relationships of PAX8, as well as other PAX family transcription factors, have never been investigated in a systematic manner. Read More

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https://jme.bioscientifica.com/view/journals/jme/aop/jme-18-
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http://dx.doi.org/10.1530/JME-18-0207DOI Listing
February 2019
4 Reads

Crystal Structure of a Ligand-free Stable TSH Receptor Leucine-Rich Repeat Domain.

J Mol Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

B Rees Smith, FIRS Laboratories, RSR Ltd, Cardiff, United Kingdom of Great Britain and Northern Ireland.

The crystal structures of the thyroid stimulating hormone receptor (TSHR) leucine-rich repeat domain (amino acids 22-260; TSHR260) in complex with a stimulating human monoclonal autoantibody (M22™) and in complex with a blocking human autoantibody (K1-70™) have been solved. However, attempts to purify and crystallise free TSHR260, i.e. Read More

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http://dx.doi.org/10.1530/JME-18-0213DOI Listing
January 2019
4 Reads

The effect of adipocyte-macrophage cross-talk in obesity-related breast cancer.

J Mol Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

I Gonul, Department of Pathology, Gazi University, Faculty of Medicine, Ankara, Turkey.

Adipose tissue is the primary source of many pro-inflammatory cytokines in obesity. Macrophage numbers and pro-inflammatory gene expression are positively associated with adipocyte size. Free fatty acid- and tumor necrosis factor-α involving vicious cycle between adipocytes and macrophages aggravates inflammatory changes. Read More

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http://dx.doi.org/10.1530/JME-18-0252DOI Listing
January 2019
12 Reads

Epigenetic Arginine Methylation in Breast Cancer: emerging therapeutic strategies.

J Mol Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

G Muscat, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.

Breast cancer is a heterogeneous disease, and the complexity of breast carcinogenesis is associated with epigenetic modification. There are several major classes of epigenetic enzymes that regulate chromatin activity. This review will focus on the nine mammalian protein arginine methyltransferases (PRMTs), and the dysregulation of PRMT expression and function in breast cancer. Read More

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http://dx.doi.org/10.1530/JME-18-0224DOI Listing
January 2019
1 Read

Aortic Effects of Thyroid Hormone in Male Mice.

J Mol Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

J Mittag, CBBM, Universitat zu Lubeck Sektion Medizin, Lubeck, Germany.

It is well established that thyroid hormones are required for cardiovascular functions; however, the molecular mechanisms remain incompletely understood, especially the individual contributions of genomic and non-genomic signalling pathways. In this study, we dissected how thyroid hormones modulate aortic contractility. To test the immediate effects of thyroid hormones on vasocontractility, we used a wire-myograph to record the contractile response of dissected mouse aortas to the adrenergic agonist phenylephrine in the presence of different doses of T3 (3,3',5-triiodothyronine). Read More

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http://dx.doi.org/10.1530/JME-18-0217DOI Listing
January 2019
4 Reads

Effects of CCK-8 and GLP-1 on fatty acid sensing and food intake regulation in trout.

J Mol Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

J Soengas, Fisioloxia Animal, Universidade de Vigo, Vigo, Spain.

We hypothesize that cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) are involved in the modulation of metabolic regulation of food intake by fatty acids in fish. Therefore, we assessed in rainbow trout (Oncorhynchus mykiss) the effects of intracerebroventricular treatment with 1 ng.g-1 of CCK-8 and with 2 ng. Read More

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http://dx.doi.org/10.1530/JME-18-0212DOI Listing
January 2019

Novel actions of sclerostin on bone.

J Mol Endocrinol 2019 Feb;62(2):R167-R185

Bone Therapeutic Area, UCB Pharma, Slough, United Kingdom.

The discovery that two rare autosomal recessive high bone mass conditions were caused by the loss of sclerostin expression prompted studies into its role in bone homeostasis. In this article, we aim to bring together the wealth of information relating to sclerostin in bone though discussion of rare human disorders in which sclerostin is reduced or absent, sclerostin manipulation via genetic approaches and treatment with antibodies that neutralise sclerostin in animal models and in human. Together, these findings demonstrate the importance of sclerostin as a regulator of bone homeostasis and provide valuable insights into its biological mechanism of action. Read More

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http://dx.doi.org/10.1530/JME-18-0176DOI Listing
February 2019
2 Reads

Novel cancer therapies and their association with diabetes.

J Mol Endocrinol 2019 Feb;62(2):R187-R199

Division of Endocrinology, Metabolism and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA.

Over the last decade, there has been a shift in the focus of cancer therapy from conventional cytotoxic drugs to therapies more specifically directed to cancer cells. These novel therapies include immunotherapy, targeted therapy and precision medicine, each developed in great part with a goal of limiting collateral destruction of normal tissues, while enhancing tumor destruction. Although this approach is sound in theory, even new, specific therapies have some undesirable, 'off target effects', in great part due to molecular pathways shared by neoplastic and normal cells. Read More

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https://jme.bioscientifica.com/view/journals/jme/62/2/JME-18
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http://dx.doi.org/10.1530/JME-18-0002DOI Listing
February 2019
10 Reads

FGF9 inhibits browning program of white adipocytes and associates with human obesity.

J Mol Endocrinol 2019 Feb;62(2):79-90

Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Shanghai, China.

Browning of white adipose tissue has been proven to be a potential target to fight against obesity and its metabolic commodities, making the exploration of molecules involved in browning process important. Among those browning agents reported recently, FGF21 play as a quite promising candidate for treating obesity for its obvious enhancement of thermogenic capacity in adipocyte and significant improvement of metabolic disorders in both mice and human. However, whether other members of fibroblast growth factor (FGF) family play roles in adipose thermogenesis and obese development is still an open question. Read More

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http://dx.doi.org/10.1530/JME-18-0151DOI Listing
February 2019

HDAC inhibitors impair Fshb subunit expression in murine gonadotrope cells.

J Mol Endocrinol 2019 Feb;62(2):67-78

Department of Pharmacology and Therapeutics, Centre for Research in Reproduction and Development, McGill University, Montreal, Quebec, Canada.

Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. Read More

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http://dx.doi.org/10.1530/JME-18-0145DOI Listing
February 2019
2 Reads

Kalirin/Trio Rho GDP/GTP exchange factors regulate proinsulin and insulin secretion.

J Mol Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

R Kuliawat, Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, 10461, United States.

Key features for progression to pancreatic β-cell failure and disease are loss of glucose responsiveness and an increased ratio of secreted proinsulin to insulin. Proinsulin and insulin are stored in secretory granules (SGs) and the fine-tuning of hormone output requires signal mediated recruitment of select SG populations according to intracellular location and age. The GTPase Rac1 coordinates multiple signaling pathways that specify SG release and Rac1 activity is controlled in part by GDP/GTP exchange factors (GEFs). Read More

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http://dx.doi.org/10.1530/JME-18-0048DOI Listing
November 2018
11 Reads

HIF 1 inhibits StAR transcription and testosterone synthesis in murine Leydig cells.

J Mol Endocrinol 2018 Oct 1. Epub 2018 Oct 1.

L Zhu, Biochemisty, Institute of Nautical Medicine, Nantong, China.

Hypoxia-inducible factor-1 (HIF1) is a critical transcription factor involved in cell response to hypoxia. Under physiological conditions, its a subunit is rapidly degraded in most tissues except testes. HIF1 is stably expressed in Leydig cells, which are the main source of testosterone for male, and might bind to the promoter region of steroidogenic acute regulatory protein (Star), which is necessary for the testosterone synthesis, according to software analysis. Read More

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http://dx.doi.org/10.1530/JME-18-0148DOI Listing
October 2018
12 Reads

Nutrient Sensor Signaling Pathways and Cellular Stress in Fetal Growth Restriction.

J Mol Endocrinol 2018 Oct 1. Epub 2018 Oct 1.

E Alejandro, Department of Integrated Biology and Physiology , University of Minnesota System, Minneapolis, United States.

Fetal growth restriction is one of the most common obstetrical complications resulting in significant perinatal morbidity and mortality. The most frequent etiology of human singleton fetal growth restriction is placental insufficiency, which occurs secondary to reduced utero-placental perfusion, abnormal placentation, impaired trophoblast invasion and spiral artery remodeling, resulting in altered nutrient and oxygen transport. Two nutrient-sensing proteins involved in placental development and glucose and amino acid transport are mechanistic target of rapamycin (mTOR) and O-linked N-acetylglucosamine transferase (OGT), which are both regulated by availability of oxygen. Read More

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https://jme.bioscientifica.com/view/journals/jme/aop/jme-18-
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http://dx.doi.org/10.1530/JME-18-0059DOI Listing
October 2018
8 Reads

Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish.

J Mol Endocrinol 2018 Oct 1. Epub 2018 Oct 1.

C Zhang, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Melanocortin receptor accessory protein 2 (MRAP2) plays an important role in regulating melanocortin receptors. In zebrafish, MRAP2a and MRAP2b show distinct pharmacological effects on MC4R activity, but how MRAP2 protein regulates other zebrafish melanocortin receptors is barely studied. Zebrafish have two mc5r genes: mc5ra and mc5rb, it is still vague which one is the homologous isoform to the mammalian paralog. Read More

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http://dx.doi.org/10.1530/JME-18-0104DOI Listing
October 2018
3.081 Impact Factor

Gremlin, Noggin, Chordin and follistatin differentially modulate BMP induced suppression of androgen secretion by bovine ovarian theca cells.

J Mol Endocrinol 2018 Oct 1. Epub 2018 Oct 1.

P Knight, Sch of Biological Sciences, Reading University, Reading, United Kingdom of Great Britain and Northern Ireland.

Bone morphogenetic proteins (BMP) are firmly implicated as intra-ovarian regulators of follicle function and steroidogenesis but information is lacking regarding the regulation of BMP signalling by extracellular binding proteins co-expressed in the ovary. In this study we compared the abilities of four BMP binding proteins (gremlin, noggin, chordin, follistatin) to antagonize the action of four different BMPs (BMP2 BMP4, BMP6, BMP7) on LH-induced androstenedione secretion by bovine theca cells in primary culture. Expression of the four BMP binding proteins and BMPs investigated here has previously been documented in bovine follicles. Read More

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https://jme.bioscientifica.com/view/journals/jme/aop/jme-18-
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http://dx.doi.org/10.1530/JME-18-0198DOI Listing
October 2018
10 Reads

SRC1 Deficiency in Hypothalamic Arcuate Nucleus Increases Appetite and Body Weight.

J Mol Endocrinol 2018 Oct 1. Epub 2018 Oct 1.

Q Ma, Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai , Shanghai, China.

Appetite is tightly controlled by neural and hormonal signals in animals. In general, steroid receptor co-activator 1 (SRC1) enhances steroid hormone signalling in energy balance and serves as a common co-activator of several steroid receptors, such as estrogen and glucocorticoid receptors. However, the key roles of SRC1 in energy balance remain largely unknown. Read More

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http://dx.doi.org/10.1530/JME-18-0075DOI Listing
October 2018
10 Reads

Novel therapies in osteoporosis: PTH-related peptide analogues and inhibitors of sclerostin.

J Mol Endocrinol 2018 Sep 1. Epub 2018 Sep 1.

E Tsourdi, Medizinische Klinik 3, Universitatsklinikum Carl Gustav Carus, Dresden, Germany.

Bone forming approaches to treat patients with severe osteoporosis are effective, but treatment options are limited and there is an unmet clinical need for additional drugs. This review discusses two novel and advanced anabolic therapeutic concepts that have successfully completed phase 3 trials. Romosozumab is a monoclonal antibody that targets the Wnt inhibitor sclerostin. Read More

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https://jme.bioscientifica.com/view/journals/jme/62/2/JME-18
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http://dx.doi.org/10.1530/JME-18-0173DOI Listing
September 2018
4 Reads

LncRNA NEAT1 promotes inflammatory response and induces corneal neovascularization

J Mol Endocrinol 2018 Oct 15;61(4):231-239. Epub 2018 Oct 15.

Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

Human corneal fibroblasts (HCFs) are implicated in corneal neovascularization (CRNV). The mechanisms underlying the inflammatory response in HCFs and the development of CRNV were explored in this study. Alkali burns were applied to the corneas of rats to establish a CRNV model. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/4/JME-18
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http://dx.doi.org/10.1530/JME-18-0098DOI Listing
October 2018
11 Reads

Cryptochrome deficiency enhances transcription but reduces protein levels of pineal Aanat

J Mol Endocrinol 2018 Oct 15;61(4):219-229. Epub 2018 Oct 15.

Research and Education Center for Brain Science, Hokkaido University, Sapporo, Japan.

Cryptochrome (Cry) 1 and 2 are essential for circadian rhythm generation, not only in the suprachiasmatic nucleus, the site of the mammalian master circadian clock, but also in peripheral organs throughout the body. CRY is also known as a repressor of arylalkylamine-N-acetyltransferase (Aanat) transcription; therefore, Cry deficiency is expected to induce constantly high pineal melatonin content. Nevertheless, we previously found that the content was consistently low in melatonin-proficient Cry1 and Cry2 double-deficient mice (Cry1−/−/Cry2−/−) on C3H background. Read More

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http://dx.doi.org/10.1530/JME-18-0101DOI Listing
October 2018
2 Reads

TRPM3/TRPV4 regulates Ca2+-mediated RANKL/NFATc1 expression in osteoblasts

J Mol Endocrinol 2018 Oct 15;61(4):207-218. Epub 2018 Oct 15.

Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea

Mechanical stress plays an important role in the regulation of bone turnover. However, the mechanism underlying hypo-osmotic stress-induced cellular response in osteoblasts remains poorly understood. In this study, we investigated the effect of hypotonic stress on the expression of bone remodeling factors, including the receptor activator of nuclear factor-kappa B ligand (RANKL) and the nuclear factor of activated T cells type c1 (NFATc1) in primary mouse osteoblasts and MC3T3-E1 cells. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/4/JME-18
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http://dx.doi.org/10.1530/JME-18-0051DOI Listing
October 2018
10 Reads

Adiponectin regulates glycogen metabolism at the human fetal–maternal interface

J Mol Endocrinol 2018 Oct 1;61(3):139-152. Epub 2018 Oct 1.

GIG – EA 7404, Université de Versailles-Saint Quentin en Yvelines – Université Paris Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France

Throughout the entire first trimester of pregnancy, fetal growth is sustained by endometrial secretions, i.e. histiotrophic nutrition. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-18
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http://dx.doi.org/10.1530/JME-18-0013DOI Listing
October 2018
16 Reads

The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development

J Mol Endocrinol 2018 Oct 1;61(3):127-138. Epub 2018 Oct 1.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Multiple signaling molecules and transcription factors are required for pituitary development. Activator-type bHLH genes Mash1, Math, NeuroD (Neurod) and Neurogenin (Neurog) are well known as key molecules in neural development. Although analyses of targeted mouse mutants have demonstrated involvement of these bHLH genes in pituitary development, studies with single-mutant mice could not elucidate their exact functions, because they cooperatively function and compensate each other. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-18
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http://dx.doi.org/10.1530/JME-18-0090DOI Listing
October 2018
8 Reads

Lipocalin 2 regulates retinoic acid-induced activation of beige adipocytes

J Mol Endocrinol 2018 Oct 1;61(3):115-126. Epub 2018 Oct 1.

Department of Food Science and Nutrition, University of Minnesota, Twin Cities, Minnesota, USA

Lipocalin-2 (LCN2) has been previously characterized as an adipokine regulating thermogenic activation of brown adipose tissue and retinoic acid (RA)-induced thermogenesis in mice. The objective of this study was to explore the role and mechanism for LCN2 in the recruitment and retinoic acid-induced activation of brown-like or ‘beige’ adipocytes. We found LCN2 deficiency reduces key markers of thermogenesis including uncoupling protein-1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) in inguinal white adipose tissue (iWAT) and inguinal adipocytes derived from Lcn2 −/− mice. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-18
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http://dx.doi.org/10.1530/JME-18-0017DOI Listing
October 2018
15 Reads

Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells

J Mol Endocrinol 2018 Oct 1;61(3):101-113. Epub 2018 Oct 1.

Department of Pathology, Hebei Medical University, Shijiazhuang, China.

Tubular injury is one of the crucial determinants of progressive renal failure in diabetic nephropathy (DN), while epithelial-to-mesenchymal transition (EMT) of tubular cells contributes to the accumulation of matrix protein in the diabetic kidney. Activation of the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome leads to the maturation of interleukin (IL)-1B and is involved in the pathogenic mechanisms of diabetes. In this study, we explored the role of NLRP3 inflammasome on high glucose (HG) or transforming growth factor-B1 (TGFB1)-induced EMT in HK-2 cells. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-18
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http://dx.doi.org/10.1530/JME-18-0069DOI Listing
October 2018
8 Reads

Mechanisms of beneficial effects of metformin on fatty acid-treated human islets

J Mol Endocrinol 2018 Oct 1;61(3):91-99. Epub 2018 Oct 1.

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

Elevated levels of palmitate accentuate glucose-stimulated insulin secretion (GSIS) after short-term and cause beta-cell dysfunction after prolonged exposure. We investigated whether metformin, the first-line oral drug for treatment of T2DM, has beneficial effects on FFA-treated human islets and the potential mechanisms behind the effects. Insulin secretion, oxygen consumption rate (OCR), AMPK activation, endoplasmic reticulum (ER) stress and apoptosis were examined in isolated human islets after exposure to elevated levels of palmitate in the absence or presence of metformin. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-17
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http://dx.doi.org/10.1530/JME-17-0304DOI Listing
October 2018
13 Reads

NFATc3 deficiency reduces the classical activation of adipose tissue macrophages

J Mol Endocrinol 2018 Oct 1;61(3):79-89. Epub 2018 Oct 1.

Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

Nuclear factors of activated T cells (NFAT) c3 have a prominent role in the regulation of proinflammatory factors in immune cells. The classically activated M1 macrophages are key players in the initiation and maintenance of adipose tissue (AT) inflammation. The role of NFATc3 in obesity and AT inflammation is unknown. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-18
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http://dx.doi.org/10.1530/JME-18-0070DOI Listing
October 2018
14 Reads

Recent insight into the correlation of SREBP-mediated lipid metabolism and innate immune response

J Mol Endocrinol 2018 Oct 1;61(3):R123-R131. Epub 2018 Oct 1.

Department of Physiology, Keimyung University School of Medicine, Daegu, South Korea

Fatty acids are essential nutrients that contribute to several intracellular functions. Fatty acid synthesis and oxidation are known to be regulated by sterol regulatory element-binding proteins (SREBPs), which play a pivotal role in the regulation of cellular triglyceride synthesis and cholesterol biogenesis. Recent studies point to a multifunctional role of SREBPs in the pathogenesis of metabolic diseases, such as obesity, type II diabetes and cancer as well as in immune responses. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-17
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http://dx.doi.org/10.1530/JME-17-0289DOI Listing
October 2018
2 Reads

The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism

J Mol Endocrinol 2018 Oct 1;61(3):R107-R121. Epub 2018 Oct 1.

The concept of replenishing or elevating NAD+ availability to combat metabolic disease and ageing is an area of intense research. This has led to a need to define the endogenous regulatory pathways and mechanisms cells and tissues utilise to maximise NAD+ availability such that strategies to intervene in the clinical setting are able to be fully realised. This review discusses the importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the recently identified nicotinamide riboside kinase pathway at both a tissue-specific and systemic level. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-18
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http://dx.doi.org/10.1530/JME-18-0085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145238PMC
October 2018
1 Read

The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases

J Mol Endocrinol 2018 10 1;61(3):R91-R105. Epub 2018 Oct 1.

Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, Korea

Mitochondria perform essential roles as crucial organelles for cellular and systemic energy homeostasis, and as signaling hubs, which coordinate nuclear transcriptional responses to the intra- and extra-cellular environment. Complex human diseases, including diabetes, obesity, fatty liver disease and aging-related degenerative diseases are associated with alterations in mitochondrial oxidative phosphorylation (OxPhos) function. However, a recent series of studies in animal models have revealed that an integrated response to tolerable mitochondrial stress appears to render cells less susceptible to subsequent aging processes and metabolic stresses, which is a key feature of mitohormesis. Read More

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https://jme.bioscientifica.com/view/journals/jme/61/3/JME-18
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http://dx.doi.org/10.1530/JME-18-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145237PMC
October 2018
5 Reads

Loss of DBC1 (CCAR2) affects TNFα-induced lipolysis and gene expression in murine adipocytes.

J Mol Endocrinol 2018 10 15;61(4):195-205. Epub 2018 Oct 15.

J Stephens, Adipocyte Biology, Pennington Biomedical Research Center, Baton Rouge, United States

STAT5A (signal transducer and activator of transcription 5A) is a transcription factor that plays a role in adipocyte development and function. In this study, we report DBC1 (deleted in breast cancer 1; also known as CCAR2) as a novel STAT5A-interacting protein. DBC1 has been primarily studied in tumor cells, but there is evidence that loss of this protein may promote metabolic health in mice. Read More

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http://dx.doi.org/10.1530/JME-18-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193813PMC
October 2018
14 Reads

Effect of TNF-α on the expression of ABCA1 in pancreatic β-cells.

J Mol Endocrinol 2018 10 15;61(4):185-193. Epub 2018 Oct 15.

K Murao, Internal Medicine, Kagawa University, Kita-gun, 761-0793, Japan

ATP-binding cassette transporter A1 (ABCA1), a 254-kD membrane protein, is a key regulator of lipid efflux from cells to apolipoproteins. ABCA1 in pancreatic β-cells influences insulin secretion and cholesterol homeostasis. Tumor necrosis factor (TNF)-α is a pleiotropic cytokine that elicits a wide spectrum of physiological events, including cell proliferation, differentiation, and apoptosis, and is also known to decrease glucose-dependent insulin secretion in pancreatic islets. Read More

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http://dx.doi.org/10.1530/JME-18-0167DOI Listing
October 2018
6 Reads

Stress and glucocorticoid receptor regulation of mitochondrial gene expression.

J Mol Endocrinol 2019 Feb;62(2):R121-R128

Glucocorticoids have long been recognized for their role in regulating the availability of energetic resources, particularly during stress. Furthermore, bidirectional connections between glucocorticoids and the physiology and function of mitochondria have been discovered over the years. However, the precise mechanisms by which glucocorticoids act on mitochondria have only recently been explored. Read More

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http://dx.doi.org/10.1530/JME-18-0152DOI Listing
February 2019

Pathobiology and genetics of adrenocortical carcinoma.

J Mol Endocrinol 2018 Aug 2. Epub 2018 Aug 2.

L Guasti, Endocrinology, Barts and the London School of Medicine, London, United Kingdom of Great Britain and Northern Ireland.

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence worldwide of 0.7-2.0 cases/million/year. Read More

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http://dx.doi.org/10.1530/JME-18-0122DOI Listing

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia.

J Mol Endocrinol 2019 Feb;62(2):R83-R103

Lady Davis Institute, SMBD JGH, McGill University, Montreal, Quebec, Canada.

Notwithstanding that metabolic perturbations and dysregulated protein synthesis are salient features of cancer, the mechanism underlying coordination of cellular energy balance with mRNA translation (which is the most energy consuming process in the cell) is poorly understood. In this review, we focus on recently emerging insights in the molecular underpinnings of the cross-talk between oncogenic kinases, translational apparatus and cellular energy metabolism. In particular, we focus on the central signaling nodes that regulate these processes (e. Read More

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http://dx.doi.org/10.1530/JME-18-0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347283PMC
February 2019
2 Reads

Defining lipid mediators of insulin resistance - controversies and challenges.

J Mol Endocrinol 2018 Aug 1. Epub 2018 Aug 1.

N Turner, Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia

Essential elements of all cells, lipids play important roles in energy production, signalling and as structural components. Despite these critical functions, excessive availability and intracellular accumulation of lipid is now recognised as a major factor contributing to many human diseases, including obesity and diabetes. In the context of these metabolic disorders, ectopic deposition of lipid has been proposed to have deleterious effects of insulin action. Read More

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http://dx.doi.org/10.1530/JME-18-0023DOI Listing
August 2018
6 Reads

The molecular pathways underlying early gonadal development.

J Mol Endocrinol 2018 Jul 24. Epub 2018 Jul 24.

M Wilson , Anatomy, University of Otago, Dunedin, New Zealand

The body of knowledge surrounding reproductive development spans the fields of genetics, anatomy, physiology and biomedicine, to build a comprehensive understanding of the later stages of reproductive development in humans and animal models. Despite this, there remains much to learn about the bi-potential progenitor structure that the ovary and testis arise from, known as the genital ridge (GR). This tissue forms relatively late in embryonic development and has the potential to form either the ovary or testis, which in turn produce hormones required for development of the rest of the reproductive tract. Read More

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http://dx.doi.org/10.1530/JME-17-0314DOI Listing
July 2018
2 Reads

ADSC-conditioned media elicit an ex vivo anti-inflammatory macrophage response.

J Mol Endocrinol 2018 10 15;61(4):173-184. Epub 2018 Oct 15.

M van de Vyver, Medicine, Stellenbosch University, Cape Town, South Africa

Obesity-associated inflammatory mechanisms play a key role in the pathogenesis of metabolic-related diseases. Failure of anti-inflammatory control mechanisms within adipose tissue and peripheral blood mononuclear cells (PBMCs) have been implicated in disease progression. This study investigated the efficacy of allogeneic adipose tissue-derived mesenchymal stem cells conditioned media (ADSC-CM) to counteract persistent inflammation by inducing an anti-inflammatory phenotype and cytokine response within PBMCs derived from patients with and without metabolic syndrome. Read More

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http://dx.doi.org/10.1530/JME-18-0078DOI Listing
October 2018

Dimethyl fumarate accelerates wound healing under diabetic condition.

J Mol Endocrinol 2018 10 15;61(4):163-172. Epub 2018 Oct 15.

H Wu, Translational Medicine, The First Hospital of Jilin University, Changchun, China

Impaired wound healing is a common complication among patients with diabetes mellitus (DM), resulting in high rates of disability and mortality. Recent findings highlighted the critical role of nuclear factor erythroid 2-related factor 2 (NRF2) - a master of cellular antioxidants scavenging excessive DM-induced free radicals - in accelerating diabetic wound healing. Dimethyl fumarate (DMF) is a potent NRF2 activator used for the treatment of multiple sclerosis. Read More

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http://dx.doi.org/10.1530/JME-18-0102DOI Listing
October 2018
19 Reads

SULFATION PATHWAYS: Contribution of intracrine oestrogens to the aetiology of endometriosis.

J Mol Endocrinol 2018 Aug;61(2):T253-T270

MRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK.

Endometriosis is an incurable hormone-dependent inflammatory disease that causes chronic pelvic pain and infertility characterized by implantation and growth of endometrial tissue outside the uterine cavity. Symptoms have a major impact on the quality of life of patients resulting in socioeconomic, physical and psychological burdens. Although the immune system and environmental factors may play a role in the aetiology of endometriosis, oestrogen dependency is still considered a hallmark of the disorder. Read More

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http://dx.doi.org/10.1530/JME-17-0297DOI Listing
August 2018
7 Reads

Steroid sulfation research has come a long way.

J Mol Endocrinol 2018 Aug;61(2):E5-E6

Institute of Metabolism and Systems ResearchUniversity of Birmingham, Birmingham, UK

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http://dx.doi.org/10.1530/JME-18-0109DOI Listing
August 2018
13 Reads

Glucolipotoxic conditions induce β-cell iron import, cytosolic ROS formation and apoptosis.

J Mol Endocrinol 2018 Aug;61(2):69-77

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Type 2 diabetes (T2D) arises when the pancreatic beta-cell fails to compensate for increased insulin needs due to insulin resistance. Glucolipotoxicity (GLT) has been proposed to induce beta-cell dysfunction in T2D by formation of reactive oxygen species (ROS). Here, we examined if modeling glucolipotoxic conditions by high glucose-high free fatty acid (FFA) exposure (GLT) regulates beta-cell iron transport, by increasing the cytosolic labile iron pool (LIP). Read More

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http://dx.doi.org/10.1530/JME-17-0262DOI Listing
August 2018
4 Reads
3.081 Impact Factor

Mechanisms of beneficial effects of metformin on fatty acid-treated human islets.

J Mol Endocrinol 2018 Jul 18. Epub 2018 Jul 18.

P Bergsten, Department of Medical Cell Biology, Uppsala university, Uppsala, Sweden.

Elevated levels of palmitate accentuate glucose-stimulated insulin secretion (GSIS) after short-term and cause beta-cell dysfunction after prolonged exposure. We investigated whether metformin, the first-line oral drug for treatment of T2DM, has beneficial effects on FFA-treated human islets and the potential mechanisms behind the effects. Insulin secretion, oxygen consumption rate (OCR), AMPK activation, ER stress and apoptosis were examined in isolated human islets after exposure to elevated levels of palmitate in the absence or presence of metformin. Read More

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http://dx.doi.org/10.1530/JME-17-0304DOI Listing
July 2018
4 Reads

TNF Signaling Impacts Glucagon-Like Peptide-1 Expression and Secretion.

J Mol Endocrinol 2018 10 15;61(4):153-161. Epub 2018 Oct 15.

Z Ying, Medicine, University of Maryland, Baltimore, Baltimore, United States

Numerous studies have implicated tumor necrosis factor α (TNFα) in the pathogenesis of type 2 diabetes. However, the role of its primary receptor, TNF receptor 1 (TNFR1), in homeostatic regulation of glucose metabolism is still controversial. In addition to TNFα, lymphotoxin α (LTα) binds to and activates TNFR1. Read More

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http://dx.doi.org/10.1530/JME-18-0129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192833PMC
October 2018
5 Reads
3.081 Impact Factor

Integrated Omics: Tools, Advances, and Future Approaches.

J Mol Endocrinol 2018 Jul 13. Epub 2018 Jul 13.

L Cox, Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, United States

With the rapid adoption of high-throughput omic approaches to analyze biological samples such as genomics, transcriptomics, proteomics, and metabolomics, each analysis can generate tera- to peta-byte sized data files on a daily basis. These data file sizes, together with differences in nomenclature among these data types, make the integration of these multi-dimensional omics data into biologically meaningful context challenging. Variously named as integrated omics, multi-omics, poly-omics, trans-omics, pan-omics, or shortened to just 'omics', the challenges include differences in data cleaning, normalization, biomolecule identification, data dimensionality reduction, biological contextualization, statistical validation, data storage and handling, sharing, and data archiving. Read More

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http://dx.doi.org/10.1530/JME-18-0055DOI Listing
July 2018
82 Reads
3.081 Impact Factor

Thyroid Function Disruptors: from nature to chemicals.

J Mol Endocrinol 2018 Jul 13. Epub 2018 Jul 13.

T Ortiga-Carvalho, Laboratório de Endocrinologia Translacional, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

The modern concept of thyroid disruptors includes man-made chemicals and bioactive compounds from food that interfere with any aspect of the hypothalamus-pituitary-thyroid axis, thyroid hormone biosynthesis and secretion, blood and transmembrane transport, metabolism and local action of thyroid hormones. This review highlights relevant disruptors that effect populations through their diet: directly from food itself (fish oil and polyunsaturated fatty acids, pepper, coffee, cinnamon and resveratrol/grapes), through vegetable cultivation (pesticides) and from containers for food storage and cooking (bisphenol A, phthalates and polybrominated diphenyl ethers). Due to the vital role of thyroid hormones during every stage of life, we review effects from the gestational period through to adulthood, including evidence from in vitro studies, rodent models, human trials and epidemiological studies. Read More

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http://dx.doi.org/10.1530/JME-18-0081DOI Listing
July 2018
23 Reads

Adiponectin regulates glycogen metabolism at the human fetal-maternal interface.

J Mol Endocrinol 2018 Jul 4. Epub 2018 Jul 4.

M Dieudonné, GIG - EA 7404, Université de Versailles-Saint-Quentin-en-Yvelines - Université Paris-Saclay, Unité de Formation et de Recherche des Sciences de la Santé Simone Veil, Montigny le Bretonneux, France

Throughout the entire first trimester of pregnancy, fetal growth is sustained by endometrial secretions, i.e histiotrophic nutrition. Endometrial stromal cells (EnSCs) accumulate and secrete a variety of nutritive molecules which are absorbed by trophoblastic cells and transmitted to the fetus. Read More

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http://dx.doi.org/10.1530/JME-18-0013DOI Listing
July 2018
12 Reads

Ovarian and Extra-Ovarian Mediators in the Development of Polycystic Ovary Syndrome.

J Mol Endocrinol 2018 10 16;61(4):R161-R184. Epub 2018 Oct 16.

V Padmanabhan, Pediatrics, University of Michigan, Ann Arbor, United States

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder affecting women of reproductive age. The origin of PCOS is still not clear and appears to be a function of gene x environment interactions. This review addresses the current knowledge of the genetic and developmental contributions to the etiology of PCOS, the ovarian and extra-ovarian mediators of PCOS and the gaps and key challenges that need to be addressed in the diagnosis, treatment and prevention of PCOS. Read More

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http://dx.doi.org/10.1530/JME-18-0079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192837PMC
October 2018

The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development.

J Mol Endocrinol 2018 Jun 25. Epub 2018 Jun 25.

S Miyamoto, Neurosurgery, Kyoto University, Kyoto, Japan.

Multiple signaling molecules and transcription factors are required for pituitary development. Activator-type bHLH genes Mash1, Math, NeuroD and Neurogenin are well known as key molecules in neural development. Although analyses of targeted mouse mutants have demonstrated involvement of these bHLH genes in pituitary development, studies with single-mutant mice could not elucidate their exact functions, because they cooperatively function and compensate each other. Read More

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http://dx.doi.org/10.1530/JME-18-0090DOI Listing
June 2018
3 Reads