2,094 results match your criteria Journal of Microencapsulation [Journal]


Niosomal delivery of pumpkin seed oil: Development, characterization, and physical stability.

J Microencapsul 2019 Apr 13:1-28. Epub 2019 Apr 13.

a Department of Pharmacy, Faculty of Pharmacy , Mahidol University , Thailand.

Pumpkin seed oil (PSO) provides many health benefits including antioxidant, cardiovascular health boost, treatment of benign prostatic hyperplasia, and reduction of hair loss. The main objective of this study was to design a suitable formulation of niosomes encapsulated PSO for topical delivery. Formulation of PSO-loaded niosomes was optimized by altering the types of surfactant and the amount of PSO:surfactant:cholesterol. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2019.1
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http://dx.doi.org/10.1080/02652048.2019.1607597DOI Listing
April 2019
1 Read

Characterization of peppermint (Mentha piperita L.) essential oil encapsulates.

J Microencapsul 2019 Apr 13:1-30. Epub 2019 Apr 13.

b Faculty of Agriculture, Department of Food Technology and Biochemistry , University of Belgrade , Nemanjina 6 , 11 080 Belgrade-Zemun , Serbia.

Aims: The aim was to choose the optimal encapsulation system and to incorporate encapsulates loaded with essential oil into ice cream as a model food product.

Methods: Ca-alginate beads were produced by electrostatic extrusion process. Gelatin/alginate coacervates were processed with coacervation. Read More

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http://dx.doi.org/10.1080/02652048.2019.1607596DOI Listing

Hybrid polymeric microspheres for enhancing the encapsulation of phenylethyl resorcinol.

J Microencapsul 2019 Apr 15:1-29. Epub 2019 Apr 15.

a College of Pharmacy and Institute of Drug Research and Development, Chungnam National University , 99 Daehak-ro, Yuseong-gu , Daejeon 34134 , Korea.

Phenylethyl resorcinol (PR) has been known to allow the whitening effect by inhibiting formation of tyrosinase. PR has solubility of 4.05 ± 0. Read More

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http://dx.doi.org/10.1080/02652048.2019.1607598DOI Listing

Self-assembly pH-sensitive Chitosan/Alginate Coated Polyelectrolyte Complexes for Oral Delivery of Insulin.

J Microencapsul 2019 Apr 8:1-30. Epub 2019 Apr 8.

a Biomaterial Research Center, School of Pharmaceutical Sciences, Southern Medical University , 1023 Southern Shatai Street , Guangzhou , Guangdong 510515 , China.

Polyelectrolyte complexes (PEC) provide new opportunities for controlled release system of drugs, and have potentials to address challenges on the way to effective oral insulin delivery. Here, an innovative pH-sensitive PEC for insulin oral administration was developed, which was formed by self-assembly of two oppositely charged nanoparticles (chitosan-coated nanoparticles and alginate-coated nanoparticles) through electrostatic interaction via optimized double emulsion method. The encapsulation efficiency of insulin-loaded alginate-coated and chitosan-coated nanoparticles were 81. Read More

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http://dx.doi.org/10.1080/02652048.2019.1604846DOI Listing

Development, characterization and efficacy evaluation of biochemical fungicidal formulations for postharvest control of anthracnose (colletotrichum gloeosporioides penz) disease in mango.

J Microencapsul 2019 Mar 28:1-34. Epub 2019 Mar 28.

a Department of Fruit and Vegetable Technology , Council of Scientific and Industrial Research, Cheluvemba Mansion, CFTRI , Mysore , 570020 India.

The objectives of the study are to develop and characterize formulations with volatile molecules in an emulsifiable concentrate form, for their antimicrobial properties and to evaluate their efficacies against C. gloeosporioides Penz., to control anthracnose in mangoes after harvest. Read More

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http://dx.doi.org/10.1080/02652048.2019.1600593DOI Listing
March 2019
1 Read

Impact of storage on the physico-chemical properties of microparticles comprising a hydrogenated vegetable oil matrix and different essential oil concentrations.

J Microencapsul 2019 Mar 27:1-11. Epub 2019 Mar 27.

c Biomin Research Centre , Tulln , Austria.

Microparticles made from hydrogenated sunflower oil without essential oil and with different essential oil concentrations (75-300 g/kg; g of essential oil per kg of microparticles) were stored for 1 or 2 months at 25 or 37 °C. Before and after storage the essential oil concentration, flowability, optical appearance, melting behaviour and crystalline structure of the microparticles were investigated. Essential oil recovery, melting behaviour and crystalline structure were identical for the essential oil containing microparticles and were not affected during storage. Read More

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http://dx.doi.org/10.1080/02652048.2019.1599456DOI Listing
March 2019
1 Read

Preparation and characterisation of polylactic acid modified polyurethane microcapsules for controlled-release of chlorpyrifos.

J Microencapsul 2019 Mar 27:1-10. Epub 2019 Mar 27.

a School of Chemical Engineering , East China University of Science and Technology , Shanghai , China.

Polyurethane modified with polylactic acid microcapsules were fabricated for controlled release of chlorpyrifos (one of the high usage solid phosphorous insecticides) via interfacial polymerisation with diphenylmethane diisocyanate, polyether triol, 1,4-butanediol and polylactic acid as modifier. The structure, morphology and release properties of synthesised microcapsules were characterised by Fourier transform infra-red spectroscopy, thermogravimetric analyser, scanning electron microscope, particle size analyser and high-performance liquid chromatography. More benign solvents, namely ethyl acetate and n-butyl acetate were used as replacement for toxic solvents commonly used in the preparation of polyurethane microcapsules, namely xylene. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2019.1
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http://dx.doi.org/10.1080/02652048.2019.1599075DOI Listing
March 2019
1 Read

Microencapsulation of an indigenous isolate of Bacillus thuringiensis by spray drying.

J Microencapsul 2019 Mar 5:1-22. Epub 2019 Mar 5.

a Department of Biology, Faculty of Sciences , Karadeniz Technical University , 61080 , Trabzon , Turkey.

In this study, microencapsulation by spray drying was performed to protect spores and crystals of indigenous isolate of Bacillus thuringiensis Se13 from environmental stress. The effects of wall material, inlet temperature, and outlet temperature on microencapsulation of Bt-Se13 were investigated using Taguchi's orthogonal array. The most suitable wall material determined as maltodextrin DE10. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2019.1
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http://dx.doi.org/10.1080/02652048.2019.1572238DOI Listing
March 2019
4 Reads

β-carotene and α-tocopherol coencapsulated in nanostructured lipid carriers of murumuru (Astrocaryum murumuru) butter produced by phase inversion temperature method: characterisation, dynamic in vitro digestion and cell viability study.

J Microencapsul 2019 Mar 5:1-10. Epub 2019 Mar 5.

a Department of Food Engineering , School of Animal Science and Food Engineering, University of São Paulo (USP) , Pirassununga , Brazil.

Hydrophobic bioactives can be more easily incorporated into food and have their bioavailability enhanced if nanostructured lipid carriers (NLC) are used as carriers. In the present study, beta-carotene-loaded NLC were produced by low emulsification using murumuru butter and a mixture of Span 80 and Cremophor RH40 as surfactants. Their average diameter was 35 nm and alpha-tocopherol was required to protect the encapsulated β-carotene. Read More

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http://dx.doi.org/10.1080/02652048.2019.1585982DOI Listing
March 2019
1 Read

Encapsulation of tagitinin C in liposomes coated by Tithonia diversifolia pectin.

J Microencapsul 2019 Feb 20:1-9. Epub 2019 Feb 20.

a Key Laboratory for Petrochemical and Refinery Technologies , Vietnam Institute of Industrial Chemistry , Hanoi , Vietnam.

Tagitinin C, a sesquiterpene lactone compound from Tithonia diversifolia, is known to have various bioactivities including anticancer effects. The disadvantages of tagitinin C which make its therapeutic application limited are low water solubility and poor stability. In this work, we encapsulated tagitinin C in the form of liposomal nanoparticles to overcome its limitations and evaluated its anticancer activity. Read More

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http://dx.doi.org/10.1080/02652048.2019.1585983DOI Listing
February 2019
1 Read

Preparation, characterisation and in vitro antibacterial property of ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection.

J Microencapsul 2019 Feb 13:1-11. Epub 2019 Feb 13.

a Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Drug Delivery and Nanomedicines Research Group , University of Nigeria , Nsukka , Nigeria.

Context: In this study, controlled ciprofloxacin (CIPRO) nanostrustructured lipid carriers of Precirol ATO 5/Transcutol HP (batch A) and tallow fat/Transcutol HP (batch B) was carreid out.

Objective: The aim was to improve solubility and bioavailability of CIPRO.

Objective: Study of controlled ciprofloxacin (CIPRO) nanostructured lipid carriers of Precirol ATO 5/Transcutol HP (batch A) and tallow fat/Transcutol HP (batch B). Read More

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http://dx.doi.org/10.1080/02652048.2019.1582724DOI Listing
February 2019
4 Reads

Influence of drying processes on the structures, morphology and in vitro release profiles of risperidone-loaded PLGA microspheres.

J Microencapsul 2019 Feb 13:1-11. Epub 2019 Feb 13.

a Chemical and Pharmaceutical Engineering Institute , Hebei University of Science and Technology , Hebei , China.

The purpose of this study was to investigate the influences of drying methods on the risperidone (RIS) release profiles of RIS-loaded PLGA microspheres. These microspheres were fabricated with an O/W emulsion solvent evaporation method. The wet microspheres were dried with freeze drying and vacuum drying methods. Read More

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http://dx.doi.org/10.1080/02652048.2019.1582723DOI Listing
February 2019
1 Read
1.585 Impact Factor

Enhanced dissolution of valsartan-vanillin binary co-amorphous system loaded in mesoporous silica particles.

J Microencapsul 2019 Feb 5:1-11. Epub 2019 Feb 5.

a Riphah Institute of Pharmaceutical Sciences , Riphah International University , Islamabad , Pakistan.

The study was aimed to prepare a co-amorphous system of valsartan (VAL) with vanillin (VAN) for improving its solubility and dissolution followed by its confinement in mesoporous silica particles (MSPs) to stabilise the co-amorphous system and prevent its recrystallization. Amorphous VAL and VAN were obtained through quench-cooling and VAL/VAN binary co-amorphous system (VAL/VAN-CAS) was prepared through solvent evaporation technique. The particle size and morphology of VAL/VAN-CAS-MSPs were studied using scanning electron microscopy (SEM) and solid-state characterisation was performed by differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD). Read More

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http://dx.doi.org/10.1080/02652048.2019.1579265DOI Listing
February 2019
1.585 Impact Factor

Soy extract and maltodextrin as microencapsulating agents for Lactobacillus acidophilus: a model approach.

J Microencapsul 2018 Nov - Dec;35(7-8):705-719

a Post Graduate Program in Food Technology , Federal Technological University of Paraná , Medianeira , Brazil.

The present study aimed to optimise the microencapsulation of Lactobacillus acidophilus La-05 by spray drying, using soy extract and maltodextrin as encapsulants. Air inlet temperature, maltodextrin/soy extract ratio and feed flow rate were investigated through Central Composite Rotational Design (CCRD). Probiotic viability increased with increasing the proportion of soy extract. Read More

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http://dx.doi.org/10.1080/02652048.2019.1579264DOI Listing
February 2019
1 Read

Surface modified kokum butter lipid nanoparticles for the brain targeted delivery of nevirapine.

J Microencapsul 2018 Nov - Dec;35(7-8):680-694

a Department of Pharmaceutical Sciences , Dibrugarh University , Dibrugarh , Assam , India.

Aim: The present work investigates the efficacy of Polysorbate 80(P80) coated Kokum butter (KB) solid lipid nanoparticles (P80NvKLNs) for the brain targeted delivery of Nevirapine (Nv).

Methods: Solid lipid nanoparticles (SLNs) were prepared by nanoprecipitation technique and evaluated for drug excipient compatibility studies, z- average particle size (nm), zeta potential (mv), percentage drug entrapment efficiency (%EE), surface morphology and in-vitro drug release properties. The in-vivo biodistribution and brain targeting efficiency of nanoparticles were studied in healthy male Wistar rat (150-200 g). Read More

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http://dx.doi.org/10.1080/02652048.2019.1573857DOI Listing
February 2019

Solid lipid nanoparticles for targeted delivery of triclosan into skin for infection prevention.

J Microencapsul 2018 Nov - Dec;35(7-8):695-704. Epub 2019 Feb 20.

a Department of Pharmacy, School of Applied Sciences , University of Huddersfield , Huddersfield , UK.

Healthcare-associated infections (HAIs) are a concern for health service providers, exacerbated by poor delivery of antimicrobials to target sites within the skin. The dermal route is attractive for local and systemic delivery of drugs, however; permeation, penetration, and access to deeper skin layers are restricted due to the barrier function of the stratum corneum (SC). Solid lipid nanoparticles present several benefits for topical delivery for therapeutic applications, especially via the follicular route. Read More

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http://dx.doi.org/10.1080/02652048.2019.1576796DOI Listing
February 2019
11 Reads

Evaluation of the anticancer activity of sprout extract-loaded nanoemulsion of N. sativa against hepatocellular carcinoma.

J Microencapsul 2018 Nov - Dec;35(7-8):643-656. Epub 2019 Feb 5.

a Department of Bioengineering , Natural Products Laboratory, Integral University , Lucknow , India.

Nigella sativa L. belonging to Ranunculaceae family is an important medicinal spice which has been utilised to treat various chronic diseases. Lipid nanoemulsions containing oil from medicinal plants have shown to enhance drug dissolvability, diminish symptoms of different powerful medications and enhance the bioavailability of medications, in contrast with conventional formulations. Read More

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http://dx.doi.org/10.1080/02652048.2019.1571641DOI Listing
February 2019

Spectroscopic and computational insights into theophylline/β-cyclodextrin complexation: inclusion accomplished by diverse methods.

J Microencapsul 2018 Nov - Dec;35(7-8):667-679. Epub 2019 Feb 5.

a Department of Chemistry , National Institute of Technology Rourkela , Rourkela , India.

Current scenario in asthmatic prevalence worldwide calls for a facile, cost-effective, and energy efficient methodology to formulate the potent bronchodilator, theophylline (THP), into an effective dosage forms. Since the uses of THP are severely impeded by its poor aqueous solubility and low bioavailability, solid inclusion complexes (ICs) of THP in β-cyclodextrin (β-CD) were prepared to overcome the limitations. The ICs were developed by conventional methods and also by microwave irradiation method, which is environmentally more benign and requires lesser reaction time. Read More

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http://dx.doi.org/10.1080/02652048.2019.1572239DOI Listing
February 2019
1 Read
1.585 Impact Factor

Mesoporous particle-based microcontainers for intranasal delivery of imidazopyridine drugs.

J Microencapsul 2018 Nov - Dec;35(7-8):657-666. Epub 2019 Feb 5.

a National Research Centre "Kurchatov Institute" , Moscow , Russia.

The aim of this study was to develop mesoporous containers for entrapment of imidazopyridines, such as sedative-hypnotic medicine zolpidem, anxiolytic agent alpidem and their derivatives. For this purpose, calcium carbonate (size 1.2 µm (PDI: 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2019.1
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http://dx.doi.org/10.1080/02652048.2019.1571642DOI Listing
February 2019
15 Reads

Low-temperature organic phase change material microcapsules for asphalt pavement: preparation, characterisation and application.

J Microencapsul 2018 Nov - Dec;35(7-8):635-642. Epub 2019 Feb 20.

b College of Transportation Engineering Key Laboratory of Road and Traffic Engineering of Ministry of Education , Tongji University , Shanghai , P. R. China.

Low-temperature phase change material (PCM) is a material that stores additional heat at elevated temperatures and releases energy when the temperature is below the limit. A way to solve the low-temperature disaster of asphalt pavement is desired to be developed. In this article, a two-component organic low-temperature PCM was encapsulated by melamine-urea-formaldehyde resin and finally reinforced with polypropylene. Read More

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http://dx.doi.org/10.1080/02652048.2018.1559248DOI Listing
February 2019
2 Reads
1.585 Impact Factor

Two-level delivery systems based on CaCO cores for oral administration of therapeutic peptides.

J Microencapsul 2018 Nov - Dec;35(7-8):619-634. Epub 2019 Jan 31.

a Institute of Macromolecular Compounds , Russian Academy of Sciences , Saint Petersburg , Russian Federation.

Two-level systems for oral delivery of therapeutic peptides were developed; the carriers consist of CaCO cores included into alginate granules. Such systems were first used for the delivery of low molecular weight drugs. It was shown that efficiency of encapsulation of peptides depends on their pI value, hydrophobicity, characteristics of the compounds used for doping CaCO cores, their surface potential and the techniques employed for loading peptides into the first-level carriers. Read More

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http://dx.doi.org/10.1080/02652048.2018.1559247DOI Listing
January 2019
3 Reads

Water-in-oil-in-water double emulsions loaded with chlorogenic acid: release mechanisms and oxidative stability.

J Microencapsul 2018 Sep;35(6):584-599

b Faculty of Science and Environment , "Dunarea de Jos" University of Galati , Galati , Romania.

Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs, and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-in-oil-in-water (W/O/W) double emulsions loaded with CA and its antioxidant capacity. Read More

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http://dx.doi.org/10.1080/02652048.2018.1559246DOI Listing
September 2018
1 Read

Preparation optimisation and storage stability of nanoemulsion-based lutein delivery systems.

J Microencapsul 2018 Sep 30;35(6):570-583. Epub 2019 Jan 30.

a School of Agriculture and Biology , Shanghai Engineering Research Center of Food Safety, Shanghai Jiao Tong University , Shanghai , China.

The present work formed lutein-enriched nanoemulsions stabilised by sodium caseinate (SC) using a high-pressure homogenisation process, and the influence of environmental conditions on the physicochemical stability of the nanoemulsion was investigated. The results showed that the droplet diameter of the nanoemulsion was largely dependent on homogenisation conditions. Optimum results were obtained for 1. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2018.1
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http://dx.doi.org/10.1080/02652048.2018.1559245DOI Listing
September 2018
29 Reads

Development and evaluation of Chrysin-Phospholipid complex loaded solid lipid nanoparticles - storage stability and in vitro anti-cancer activity.

J Microencapsul 2018 Sep;35(6):600-617

c Divisions of Metabolism and Pharmacokinetics , CSIR-Central Drug Research Institute , Lucknow , Uttar Pradesh , India.

Context: Flavonoids show promising anticancer potential but it is limited due to poor solubility.

Objective: The present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluated for potential increase in the anti-cancer activity against MCF-7 cell line.

Methods: The physiochemical characteristics and release kinetics for Ch-SLNs and Ch-PC-SLNs were evaluated and compared. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2018.1
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http://dx.doi.org/10.1080/02652048.2018.1559369DOI Listing
September 2018
14 Reads

Glutathione decorated gold-magnetic nanoparticles: efficient and recyclable catalyst for biotechnological and pharmaceutical applications.

J Microencapsul 2018 Sep 22;35(6):559-569. Epub 2019 Jan 22.

b Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

Nowadays, since the core-shell gold-magnetite nanoparticles include the saturation magnetisation (iron oxide) and plasmon surface (gold shell) properties, they have been considered in biological and biomedicine research areas. In the present work, multifunctional glutathione decorated gold-coated iron oxide nanoparticles (GSH-AuMNPs) were successfully synthesised and fully characterised. From the absorption peak at 525, the formation of the core-shell GSH-AuMNPs was confirmed. Read More

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http://dx.doi.org/10.1080/02652048.2018.1554011DOI Listing
September 2018
1 Read

A mechanistic study of the effect of transferrin conjugation on cytotoxicity of targeted liposomes.

J Microencapsul 2018 Sep 30;35(6):548-558. Epub 2018 Nov 30.

a Nanotechnology Research Center , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

This study was performed to prepare 5-fluorouracil (5FU) containing targeted liposomes for the safety and efficacy enhancement. Liposomes were prepared using thin layer method and transferrin (Tf) was employed as the targeting ligand. Morphology of 5FU-loaded liposomes was assessed by transmission electron microscopy (TEM). Read More

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http://dx.doi.org/10.1080/02652048.2018.1547325DOI Listing
September 2018
8 Reads

Compound pesticide controlled release system based on the mixture of poly(butylene succinate) and PLA.

J Microencapsul 2018 Aug 27;35(5):494-503. Epub 2018 Nov 27.

a Southern Regional Collaborative Innovation Center for Grain and Oil Crops , College of Plant Protection, Hunan Agricultural University , Changsha , China.

Controlled release system has been widely developed and utilised in agriculture to optimise efficacy and minimise environmental pollution. Here, the azoxystrobin and difenoconazole compound pesticide microsphere was constructed by the solvent evaporation method. Blending poly (butylene succinate) (PBS) and poly (lactic acid) (PLA) as shells, in order to increase its entrapment efficiency and match the goal of complex synergism. Read More

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http://dx.doi.org/10.1080/02652048.2018.1538265DOI Listing
August 2018
2 Reads

Microencapsulation of blackberry pulp with arrowroot starch and gum arabic mixture by spray drying.

J Microencapsul 2018 Aug 30;35(5):482-493. Epub 2018 Nov 30.

a School of Agricultural Engineering , University of Campinas , Campinas , Brazil.

This research work aimed to obtain blackberry pulp powder by spray drying and, by an experimental design, evaluated the effect of inlet air temperature (100-150 °C) and blackberry pulp solids:arrowroot starch/gum arabic solids ratio of 1:0.5-1:2 on the physicochemical properties of the powders. Arrowroot starch and gum arabic present glass transition temperature (Tg) values above 100 °C; hence it was possible to employ them as carriers in blackberry pulp spray drying in order to increase Tg of the system. Read More

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http://dx.doi.org/10.1080/02652048.2018.1538264DOI Listing
August 2018
3 Reads

Effects of polymerised whey protein-based microencapsulation on survivability of Lactobacillus acidophilus LA-5 and physiochemical properties of yoghurt.

J Microencapsul 2018 Aug 30;35(5):504-512. Epub 2018 Nov 30.

a College of Food Science , Northeast Agriculture University , Harbin , China.

Lactobacillus acidophilus LA-5 has poor survivability in yoghurts. This study aims to microencapsulate L. acidophilus LA-5 using polymerised whey protein as wall material and evaluate its survivability and effects on physiochemical properties of yoghurts. Read More

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http://dx.doi.org/10.1080/02652048.2018.1538266DOI Listing
August 2018
4 Reads

Genipin crosslinked curcumin loaded chitosan/montmorillonite K-10 (MMT) nanoparticles for controlled drug delivery applications.

J Microencapsul 2018 Aug 21;35(5):439-453. Epub 2018 Nov 21.

a Department of Chemical Sciences , Tezpur University , Napaam , India.

Here, we have reported the influence of MMT and genipin in releasing curcumin from the Genipin crosslinked Chitosan/MMT nanoparticles, prepared by ionic gelation method. The nanoparticles were characterised using Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometry (XRD), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM). Zeta potential and average diameter of the nanoparticles were found in the range 32-47 mV and 430-560 nm. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2018.1
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http://dx.doi.org/10.1080/02652048.2018.1524524DOI Listing
August 2018
2 Reads

The effect of polymer molecular weight and cell seeding density on viability of cells entrapped within PEGDA hydrogel microspheres.

J Microencapsul 2018 Aug 30;35(5):475-481. Epub 2018 Nov 30.

a Biomedical Engineering , Rutgers University , New Brunswick , NJ , USA.

Cell microencapsulation can be used in tissue engineering as a scaffold or physical barrier that provides immunoisolation for donor cells. When used as a barrier, microencapsulation shields donor cells from the host immune system when implanted for cell therapies. Maximizing therapeutic product delivery per volume of microencapsulated cells necessitates first optimising the viability of entrapped cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2018.1
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http://dx.doi.org/10.1080/02652048.2018.1526341DOI Listing
August 2018
3 Reads

Bovine serum albumin nanoparticles improve the antitumour activity of curcumin in a murine melanoma model.

J Microencapsul 2018 Aug 30;35(5):467-474. Epub 2018 Nov 30.

b Laboratory of Pharmaceutical Nanotechnology , Universidade Estadual do Centro-Oeste/UNICENTRO , Guarapuava , Brazil.

Curcumin is a natural compound presenting important antitumour activity. However, due to its low aqueous solubility, instability at physiological pH, and low oral bioavailability, its clinical use is limited. Bovine serum albumin (BSA) nanoparticles have been used as drug carriers to improve the drug properties. Read More

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http://dx.doi.org/10.1080/02652048.2018.1526340DOI Listing
August 2018
3 Reads

Preparation, optimisation, and in vitro-in vivo evaluation of febuxostat ternary solid dispersion.

J Microencapsul 2018 Aug 27;35(5):454-466. Epub 2018 Dec 27.

a Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals , Zhejiang University of Technology , Hangzhou , PR China.

The research aimed to prepare febuxostat (FEB) solid dispersion through solvent evaporation. Optimised solid dispersion composed of FEB, polyvinylpyrrolidone (PVP K30) and poloxamer at a ratio of 1:3:3 was characterised. Powder X-ray diffraction (XRD) and differential scanning calorimetry (DSC) indicated FEB was transformed from crystalline into the amorphous state in solid dispersion and scanning electron microscopy (SEM) revealed the morphology. Read More

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http://dx.doi.org/10.1080/02652048.2018.1526339DOI Listing
August 2018
4 Reads

Design of ciprofloxacin-loaded nano-and microcomposite particles for dry powder inhaler formulations: preparation, in vitro characterisation, and antimicrobial efficacy.

J Microencapsul 2018 Sep 27;35(6):533-547. Epub 2019 Jan 27.

a Faculty of Pharmacy, Department of Pharmaceutical Technology , Ankara University , Ankara , Turkey.

In this study, ciprofloxacin hydrochloride (CIP)-loaded poly-ε-caprolactone (PCL) nanoparticles were prepared for pulmonary administration. CIP-loaded PCL nanoparticles were prepared using solid-in-oil-in-water (s/o/w) emulsion solvent evaporation method, and the effects of various formulation parameters on the physicochemical properties of the nanoparticles were investigated. PCL nanoparticles showed spherical shapes with particle sizes around 143-489 nm. Read More

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http://dx.doi.org/10.1080/02652048.2018.1523970DOI Listing
September 2018
5 Reads

Preparation and characterisation of flame retardant encapsulated with functionalised silica-based shell.

J Microencapsul 2018 Aug 23;35(5):428-438. Epub 2018 Oct 23.

b FPInnovations , Quebec , QC , Canada.

Intumescent fire retardant (IFR) coatings are nowadays considered as the most effective flame retardant (FR) treatment. Nevertheless, the principal compound in an IFR system, ammonium polyphosphate (APP), is highly sensitive to moisture and IFR coating effectiveness decreases quickly. The main objective of this study is to encapsulate APP in a hybrid silica-based membrane by sol-gel process using alkoxysilane tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES) precursor. Read More

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http://dx.doi.org/10.1080/02652048.2018.1521477DOI Listing
August 2018
4 Reads

Formation of essential oil containing microparticles comprising a hydrogenated vegetable oil matrix and characterisation thereof.

J Microencapsul 2018 Sep 27;35(6):513-521. Epub 2018 Dec 27.

c Biomin Research Centre, Technopark 1 , Tulln , Austria.

Microparticles with different essential oil concentrations 0, 75, 150, 225 and 300 gkg, (g of essential oil per kg of microparticles), were produced by dispersing the essential oils within a hydrogenated vegetable fat matrix and forming spherical solid particles by spray-chilling. Size distribution, flowability, surface structure, essential oil recovery, melting properties and crystallinity of the microparticles were determined. With over 225 gkg essential oil the microparticle surface became stickier, their flowability was reduced and the size distribution broadened. Read More

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http://dx.doi.org/10.1080/02652048.2018.1515998DOI Listing
September 2018
3 Reads

Cell encapsulation potential of chitosan-alginate electrostatic complex in preventing natural killer and CD8 cell-mediated cytotoxicity: an in vitro experimental study.

J Microencapsul 2018 Sep 27;35(6):522-532. Epub 2018 Dec 27.

a Division of Stem Cell & Gene Therapy Research , Institute of Nuclear Medicine & Allied Sciences , Delhi , India.

Natural killer and cytotoxic CD8+ T cells are involved in the rapid clearance of cells which express foreign antigens. Hence, these cells are crucial elements of the vertebrate immune system. However, these benefits turn problematic when they cause transplant rejection through their direct cytotoxic effects on donor organs/cells, which is attributed to the human leukocyte antigen disparity. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2018.1
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http://dx.doi.org/10.1080/02652048.2018.1516827DOI Listing
September 2018
19 Reads
1.585 Impact Factor

Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability.

J Microencapsul 2018 Aug 9;35(5):421-427. Epub 2018 Oct 9.

a College of Pharmacy & Institute of Pharmaceutical Science and Technology , Hanyang University , Sangnok-gu, Ansan , South Korea.

To develop a novel revaprazan-loaded gelatine microsphere with enhanced solubility and oral bioavailability, numerous gelatine microspheres were prepared using a spray-drying technique. The impact of gelatine amount on drug solubility in the gelatine microspheres was investigated. The physicochemical properties of the selected gelatine microsphere, such as shape, particle size and crystallinity, were evaluated. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2018.1
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http://dx.doi.org/10.1080/02652048.2018.1515997DOI Listing
August 2018
5 Reads

Chitosan/β-glycerophosphate-based microparticles manufactured by laminar jet break-up technology.

J Microencapsul 2018 Aug 9;35(5):407-420. Epub 2018 Oct 9.

a Division of Pharmacy and Optometry , University of Manchester , Manchester , UK.

This study is about the use of β-glycerophosphate (βGP) to modulate the production of chitosan microparticles through a technology of jet break-up. βGP has been described as capable of producing chitosan gels without additional complexing agents via a thermal transition (inverse gelation). A preliminary assessment on the effect of temperature on the viscosity and gelation of chitosan/βGP precursors demonstrated that the crosslinking process was too slow to afford microparticle production via jet break-up. Read More

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http://dx.doi.org/10.1080/02652048.2018.1515996DOI Listing

Spray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugs.

J Microencapsul 2018 Jun;35(4):392-405

a Centre for Biomedical Research , University of Algarve , Faro , Portugal.

Pulmonary tuberculosis accounts for 80% of cases and the delivery of antitubercular drugs into the lungs allows targeting the infected organ and, possibly, reducing systemic drug toxicity. This work aimed at using fucoidan as matrix of inhalable microparticles that associate two first-line antitubercular drugs, for an application in pulmonary tuberculosis therapy. Fucoidan is composed of fucose and sulphated sugar residues, moieties described as being recognised by surface receptors of alveolar macrophages, which host mycobacteria. Read More

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http://dx.doi.org/10.1080/02652048.2018.1513089DOI Listing
June 2018
1 Read

Formation of organosilica nanoparticles with dual functional groups and simultaneous payload entrapment.

J Microencapsul 2018 Jun;35(4):381-391

b Faculty of Pharmacy , National Yang-Ming University , Taipei , Taiwan.

A mixed organosilane system for simultaneous formation of organosilica nanoparticles has been systematically studied for loading of various compounds with a wide range of log P values. The molecule-entrapping system was understood by investigating the effects of adjusting various experimental parameters on particle formation and molecule entrapment. Particularly, rhodamine 6 G (R6G) loaded colloidal particles were prepared and characterised in detail. Read More

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http://dx.doi.org/10.1080/02652048.2018.1508314DOI Listing
June 2018
1 Read

Colon targeted curcumin microspheres laden with ascorbic acid for bioavailability enhancement.

J Microencapsul 2018 Jun;35(4):372-380

b Department of Pharmaceutics , Bharati Vidyapeeth College of Pharmacy , Kolhapur , India.

An objective of the present study was to prepare colon-specific microspheres of curcumin (CUR) containing ascorbic acid (AA) for improved oral bioavailability. 3 factorial design was used to optimise chitosan microspheres (CSMS) containing CUR and AA. Subsequently, optimised CSMS were coated with Eudragit S-100, for delivery to colon. Read More

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http://dx.doi.org/10.1080/02652048.2018.1501111DOI Listing
June 2018
25 Reads

A comparative study of stabilising effect and antioxidant activity of different antioxidants on levodopa-loaded liposomes.

J Microencapsul 2018 Jun 22;35(4):357-371. Epub 2018 Jul 22.

a Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy , Universidad de Sevilla , Seville , Spain.

The aim of this study was to evaluate the stability of levodopa liposomes co-loaded with three different antioxidants (curcumin, ascorbic acid, and superoxide dismutase (SOD)). For this purpose, multilamellar liposomes were prepared. Curcumin was added into the lipid bilayer while ascorbic acid and SOD were placed into the aqueous phase. Read More

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https://www.tandfonline.com/doi/full/10.1080/02652048.2018.1
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http://dx.doi.org/10.1080/02652048.2018.1487473DOI Listing
June 2018
5 Reads

Design of minocycline-containing starch nanocapsules for topical delivery.

J Microencapsul 2018 Jun 14;35(4):344-356. Epub 2018 Aug 14.

a Faculty of Pharmacy, Research Institute for Medicines (iMed.ULisboa) , Universidade de Lisboa , Lisboa , Portugal.

Pharmaceutical research has been focussed on developing improved delivery systems while exploring new ways of using approved excipients. The present work investigated the potential of starch nanocapsules (StNC) as a topical delivery platform for hydrophilic antimicrobial drugs using minocycline hydrochloride (MH) as a model drug. Thus, a quality by design approach was used to assess the role of different factors that affect the main pharmaceutical properties of StNC prepared using an emulsification-solvent evaporation method. Read More

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http://dx.doi.org/10.1080/02652048.2018.1487472DOI Listing
June 2018
8 Reads

Improvement of oral efficacy of Irinotecan through biodegradable polymeric nanoparticles through in vitro and in vivo investigations.

J Microencapsul 2018 Jun 9;35(4):327-343. Epub 2018 Jul 9.

e Nanomedicine Lab, Department of Pharmaceutics, School of Pharmaceutical Education and Research , Jamia Hamdard , New Delhi , India.

Background: Irinotecan (IRN) (CPT-11) is a camptothecin derivative with low oral bioavailability due to active efflux by intestinal P-glycoprotein (p-gp) receptors. Hence, no oral formulation is marketed for IRN till date and its oral ingestion continues to remain a challenge.

Aim Of Study: The study aims to develop a nanoformulation i. Read More

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http://dx.doi.org/10.1080/02652048.2018.1485755DOI Listing
June 2018
7 Reads
1.585 Impact Factor

Development and characterisation of polymeric microparticle of poly(d,l-lactic acid) loaded with holmium acetylacetonate.

J Microencapsul 2018 May 14;35(3):281-291. Epub 2018 Jun 14.

c Department of Organic Chemistry, Institute of Chemistry , UNICAMP SP , São Paulo , Brazil.

Biodegradable polymers containing radioactive isotopes such as Holmium 166 (Ho) have potential applications as beta particle emitters in tumour tissues. It is also a gamma ray emitter, allowing nuclear imaging of any tissue to be acquired. It is frequently used in the form of complexes such as holmium acetylacetonate (HoAcAc), which may cause damages in tissues next to the targets cancer cells, as it is difficult to control its linkage or healthy tissues radiotherapy effects. Read More

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http://dx.doi.org/10.1080/02652048.2018.1477843DOI Listing
May 2018
2 Reads

Design and development of vitamin C-encapsulated proliposome with improved in-vitro and ex-vivo antioxidant efficacy.

J Microencapsul 2018 May 6;35(3):301-311. Epub 2018 Jun 6.

c Department of Quality Control, School of Pharmacy , Shiraz University of Medical Sciences , Shiraz , Iran.

Vitamin C, as an antioxidant additive in pharmaceutical and food products, is susceptible to environmental conditions, and new design strategies are needed to enhance its stability. The aim of this study is to prepare vitamin C proliposome using film deposition on the carrier by applying different factors, and optimise the characteristics of the obtained powder using the design expert software. The optimised formulation demonstrated acceptable flowability with 20% vitamin C loading. Read More

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http://dx.doi.org/10.1080/02652048.2018.1477845DOI Listing
May 2018
4 Reads

Tamoxifen citrate loaded chitosan-gellan nanocapsules for breast cancer therapy: development, characterisation and in-vitro cell viability study.

J Microencapsul 2018 May 8;35(3):292-300. Epub 2018 Jun 8.

a Department of Pharmaceutics, SLT Institute of Pharmaceutical Sciences , Guru Ghasidas Vishwavidyalaya , Bilaspur , India.

The objective of this study was to evaluate the potential of chitosan-gellan nanocapsules (CGNCs) for encapsulation and sustained release of Tamoxifen citrate (TMC) for breast cancer therapy. Polyelectrolyte complex coacervation method was used for production of CGNCs. Interaction studies were conducted by Fourier-transform infra-red (FT-IR), differential scanning colorimetric (DSC), and X-ray diffraction (XRD) to investigate any interaction between drug and excipients. Read More

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http://dx.doi.org/10.1080/02652048.2018.1477844DOI Listing
May 2018
9 Reads

Synthesis, screening and nanocrystals preparation of rhein amide derivatives.

J Microencapsul 2018 Jun;35(4):313-326

b Research Center for Computer Simulating and Information Processing of Bio-macromolecules of Liaoning Province , Shenyang , P.R. China.

Rhein (RH) has many bioactivities, but the application was limited of its poor solubility. The present study aimed to establish an efficient method for the synthesis of rhein amide derivatives (RAD) to increase the solubility and anti-tumour activity. RAD exhibited stronger anti-tumour activity than RH in MTT assay. Read More

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http://dx.doi.org/10.1080/02652048.2018.1467510DOI Listing
June 2018
30 Reads
1.580 Impact Factor

Preparation and evaluation of a chitosan-coated antioxidant liposome containing vitamin C and folic acid.

J Microencapsul 2018 May 3;35(3):272-280. Epub 2018 May 3.

c School of Chemistry and Chemical Engineering , Southeast University Chengxian College , Nanjing , China.

Vitamin C (VC) and folic acid (FA) are the important nutrient and antioxidant in human body. In order to improve their stability, their co-loaded liposomes (VCFA-Lip) and chitosan-coated liposomes (CS-VCFA-Lip) are prepared and characterised. The mean particle size of VCFA-Lip and CS-VCFA-Lip is 138 nm and 249 nm, respectively. Read More

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http://dx.doi.org/10.1080/02652048.2018.1467509DOI Listing
May 2018
7 Reads