27,558,239 results match your criteria Journal of Medicine and Medical Sciences JMMS [Journal]

  • Page 1 of 551165

[Recent studies on the signaling pathways implicated myopia].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):148-152

Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, China.

Myopia has emerged as one of the major health issues in China given its increasingly high prevalence. It is generally accepted that myopia is the result of a complex interaction of environmental exposures and genetic predisposition. Many studies have indicated that abnormal visual stimulation regulates retinal neurotransmitters and growth factors to release resulting in scleral remodeling and axial elongation through signaling pathway transduction. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.016DOI Listing
February 2019

[Efficacy of deproteinized calf blood extract eye drops on early recovery after pterygium surgery].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):134-140

Department of Ocular Surface and Corneal Diseases, the Affiliated Xiamen Eye Center of Xiamen University, Xiamen 361001, China.

To investigate the effect of deproteinized calf blood extract eye drops on early postoperative recovery in primary pterygium patients. This is a prospective randomized controlled study. Patients diagnosed with primary pterygium in single eye at affiliated Xiamen Eye Center of Xiamen University during March 2016 to May 2016 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.012DOI Listing
February 2019

[Clinical features, treatment distribution and outcomes of Mooren's ulcer].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):127-133

Qingdao Eye Hospital, Shandong Eye Institute, Qingdao 266071, China.

To investigate the clinical features, treatment distribution and transition of Mooren's ulcer, and to observe the clinical outcomes and recurrence. Retrospective series case study. Medical records of 125 patients (154 eyes) with Mooren's ulcer treated between January 1996 and December 2015 at our hospital were retrospectively reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.011DOI Listing
February 2019

[Clinical outcomes after laser epithelial keratomileusis (LASEK) and transepithelial photorefractive keratectomy (TPRK) in myopia].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):122-126

Peking Union Medical College Hospital, Beijing 100730, China.

To compare the clinical outcomes between laser epithelial keratomileusis (LASEK) and transepithelial photorefractive keratectomy (TPRK) for treatment of myopia. Case-control study. We reviewed a total of 90 right eyes that underwent either LASEK or TPRK, with 45 eyes in each group (aged between 18 and 40 years; 9 males and 16 females in the LASEK group, and 30 males and 15 females in the TPRK group) from 2015 to 2016 in Peking Union Medical College Hospital and Tangshan Eye Hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.010DOI Listing
February 2019

[The effect of corneal biomechanical properties on opaque bubble layer in small incision lenticule extraction (SMILE)].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):115-121

Tianjin Medical University, Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China.

To investigate the influence of corneal biomechanical properties on opaque bubble layer (OBL) in small incision lenticule extraction (SMILE). In this nested case control study, 20 patients (31 eyes) were enrolled in OBL group, while 51 patients (98 eyes) were included in non-OBL group. The parameters were obtained by Pentacam HR and Corvis ST examinations. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.009DOI Listing
February 2019

[Choroidal thickness in preschool children].

Authors:
Z Kang H Yang

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):111-114

Xiamen Pediatric Hospital Affiliated to Fudan University, Xiamen Children's Hospital, Xiamen 361000, China.

To estimate the choroidal thickness (CT) in healthy children aged 2-6 years old and its relation to axial length, age and gender. Cross-sectional study. CT was assessed using spectral domain optical coherence tomography (OCT) in 126 children aged 2 to 6 years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.008DOI Listing
February 2019

[A machine learning model on orthokeratology lens fitting based on the data of optometry examination].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):105-110

Beijing Internet Eyecare Technology Clinic, Beijing 100027, China.

To get an orthokeratology lens fitting model according to the research of the optometry examination data, which can help to improve the work efficiency and increase the hitting rate of prescription. The relationship between the basic optometry examination data and the effective optometry prescription was evaluated. We got 1 467 sets of data, including 80%(1 173) for training and 20%(294) for testing. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.007DOI Listing
February 2019

[Clinical study on microcirculation changes of bulbar conjunctiva after contact lens wear].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):98-104

School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, China.

To explore the changes of microcirculation of the bulbar conjunctiva after wearing the contact lens and the relationship between contact lens discomfort and bulbar conjunctiva microcirculation. Prospective cohort study. The postgraduate students from School of Ophthalmology & Optometry and School of Biomedical Engineering of Wenzhou Medical University were included in this prospective cohort study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.006DOI Listing
February 2019

[From evidence to clinical practice: myopia control among children in refraction clinics].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):89-92

Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, China.

Over the past decade, breakthrough has been made on myopia progression control with a lot of evidence from clinical trials, but the effective clinical application of many of them remained immature. Though refraction clinics have been set up in many specialized hospitals offering spectacles to correct refractive error, there was few protocol or standard of treatment for reducing myopia progression. This commentary reviews the latest and essential publications and presents critical advice on applying the research findings to clinical practice. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.003DOI Listing
February 2019

[It is essential to diagnose and correct children's ametropia after cycloplegic refraction].

Authors:
R Y Chu J L Zhao

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):86-88

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

It is essential to diagnose and assess children's ametropia after cycloplegic refraction. The use of cyclopentolate 1% eyedrops in children is safe and effective for cycloplegic refraction. An accurate prescription should be based on the actual eye position and accommodation, as well as cycloplegic refraction in children. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.002DOI Listing
February 2019

[Effective prevention and control of myopia in children and adolescents].

Authors:
J Qu F Lyu L D Xu

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):81-85

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Engineering Research Center For Myopia Control and Management, Ministry of Education, Wenzhou 325000, China.

Myopia prevention and control is an important health issue related to children and adolescents, general public physical fitness and national defense security. In 2018, General Secretary Xi Jinping gave instructions on students' myopia. Ministry of Education and other seven ministries and commissions issued the Implementation Plan of the Myopia Prevention and Control for Children and Adolescents. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.001DOI Listing
February 2019

[Performance of Knosp grade for cavernous sinus invasion of Cushing's disease].

Authors:
X Y Xu R Z Wang

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):388-390

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To review the outcomes in patients with Cushing's disease (CD) after transsphenoidal surgery (TSS) and to assess the performance of Knosp grade for cavernous sinus invasion (CSI). Medical records were reviewed for patients with CD undergoing TSS from 1978 to 2017 at Peking Union Medical College Hospital. Based on whether CSI was observed during surgery, the sensitivity and specificity of Knosp grade for CSI were evaluated. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.014DOI Listing
January 2019

[Comparison of the accuracy of neuronavigation and linear measurement in the positioning of parasagittal meningioma].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):384-387

Department of Neurosurgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.

To explore the accuracy of preoperative positioning of neuronavigation and linear measurement localization in the parasagittal meningioma. Thirty-eight patients with parasagittal meningioma who underwent neurosurgery in the First Affiliated Hospital of Bengbu Medical College from January 2016 to April 2018 were preoperatively positioned with neuronavigation localization and linear measurement localization. The actual position of the tumor was observed during operation, and the accuracy of the two methods was compared. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.013DOI Listing
January 2019
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[Study on the risk factors for hemorrhagic transformation of cerebellar infarction after posterior fossa decompression surgery].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):380-383

Department of Neurosurgery, Jinhua Municipal Central Hospital, Jinhua 321000, China.

To investigate the related risk factors for hemorrhagic transformation (HT) of cerebellar infarction after posterior fossa decompression surgery. A total of 91 patients with cerebellar infarction were treated by posterior fossa decompression surgery in Department of Neurosurgery of Jinhua Municipal Central Hospital from Jan 2010 to Jan 2018, were selected as study subjects. The HT group included 17 cases, while the Non-HT group included 74 cases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.012DOI Listing
January 2019

[Evaluation of the effect of electrical stimulation combined with biofeedback therapy for postpartum pelvic organ prolapse: a static and dynamic magnetic resonance imaging study].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):375-379

Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, China.

To explore the clinical value of static and dynamic magnetic resonance imaging (MRI) in evaluating the effect of electrical stimulation combined with biofeedback in the treatment of pelvic organ prolapse postpartum. A total of 50 primiparas diagnosed as pelvic organ prolapse postpartum from February 2016 to November 2017 were randomly divided into treatment group (24 cases) and control group (26 cases). The control group recovered spontaneously, and the treatment group received electric stimulation combined with biofeedback therapy (6 weeks). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.011DOI Listing
January 2019

[The relationship between simple numerical function and gray matter volume in normal brain aging].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):370-374

Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To explore the relationship between simple numerical function and gray matter volume (GMV) in normal brain aging using the voxel-based morphometry(VBM) approach. A total of 123 individuals from 18 to 70 years old (63 males,60 females,the average age was (43±14) years, were recruited from right-handed healthy Han Chinese volunteers at the Department of MRI at the First Affiliated Hospital of Zhengzhou University between October 2016 and June 2017. All subjects underwent magnetic resonance sagital three-dimensional imaging scanning, and statistical parameter graph (SPM) 8 software was used for voxel-based morphological analysis to compare the differences in gray matter volume between different age groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.010DOI Listing
January 2019

[Predictive value of white blood cell, procalcitonin and high-sensitivity C-reactive protein for the bloodstream infection in the super-elderly critically-ill patients].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):365-369

Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ability of white blood cell (WBC), procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the super-elderly patients with bloodstream infection. It was a retrospective study. A total of 77 patients (≥85 years) admitted to the ICU of Peking Union Medical College Hospital from June, 2016 to December, 2017 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.009DOI Listing
January 2019
1 Read

[Surgical results and sagittal alignment analysis of different fusion levels for degenerative scoliosis].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):359-364

Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To retrospectively investigate the effects of long segment fusion and short segment fusion on lumbar sagittal alignment and quality of life in patients with degenerative scoliosis. From January 2011 to December 2014, 75 patients with degenerative scoliosis were treated with pedicle screw fixation. Total of 56 females and 19 males were included in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.008DOI Listing
January 2019

[PLA2G6 compound complicated mutation in an atypical neuroaxonal dystrophy pedigree].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):354-358

Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou 450003, China.

To analyze the clinical presentation, imaging features, and the mutation of the pathogenic genes in a Chinese Han atypical neuroaxonal dystrophy pedigree. A family of atypical neuroaxonal dystrophy pedigree who came to Henan Provincal People's Hospital in July 2016 was included. Clinical presentation, imaging features of the pedigree were analyzed, and all exon gene detection of the proband was performed to capture the target variations, then verified by sanger sequence. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.007DOI Listing
January 2019

[Efficacy and mechanism of loading dose clopidogrel in patients with transient ischemic attack and minor stroke].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):349-353

Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou 215000, China.

To assess outcome, safety and possible mechanism of loading dose clopidogrel in patients with transient ischemic attack (TIA) and minor stroke. We reviewed patients with confirmed TIA and minor stroke admitted between July 2016 and December 2017 into the First Affiliated Hospital of Soochow University. Loss-of-function allele carriers of CYP2C19 were included and randomly divided into loading dose group (first dose of 300 mg clopidogrel) and standard dose group (first dose of 75 mg clopidogrel), 100 mg aspirin was gave at the same time, followed by aspirin 100 mg/d plus clopidogrel 75 mg/d maintaining for 20 days. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.006DOI Listing
January 2019

[Biomarkers screening for viral myocarditis through proteomics analysis of plasma exosomes].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):343-348

Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450000, China.

To compare and analyze the differentially expressed plasma exosomic proteome between healthy control group (Control group) and viral myocarditis group (VMC group) to search for biomarkers that maybe used for early diagnosis of VMC. Fifty plasma samples of Control group and VMC group were collected respectively from Henan Provincial People's Hospital (from January 2016 to December 2017), and then 5 samples (1 ml) of each group were selected randomly, after exosomes extraction with ultra-centrifugation, difference gel electrophoresis (DIGE) was used to isolate the total proteins, and then the protein spots with more than 2-fold changes between VMC and Control group were picked up after the software analysis, afterward, the varied proteins were identified by MALDI-TOF/TOF mass spectrometry. Finally, the specifically related protein was selected to be verified by ELISA with the plasma exosomic samples of Control (40) and VMC (40). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.005DOI Listing
January 2019
1 Read

[Quantitative evaluation of intravoxel incoherent motion diffusion-weighted imaging and three-dimensional arterial spin labeling in Ki-67 labeling index and grading of brain gliomas].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):338-342

Department of Pathology, Li Huili Hospital, Ningbo Medical Center, Ningbo 315040, China.

To investigate the value of multiple parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional arterial spin labeling (3D-ASL) in Ki-67 labeling index (Ki-67 LI) and grading of human brain gliomas. From December 2015 to May 2018, 45 patients of gliomas confirmed by surgical pathology in Li Huili Hospital, Ningbo Medical Center were divided into low-grade group (20 cases of WHO grade Ⅱ) and high-grade group (12 cases of WHO grade Ⅲ, 13 cases of WHO grade Ⅳ), and the Ki-67 LI of glioma was obtained by immunohistochemistry. All patients, 24 males and 21 females, aged 25-83 years, mean(53±12)years, underwent conventional magnetic resonance imaging (MRI), IVIM-DWI and 3D-ASL before operation, then measured the true water diffusion coefficient (D), microcirculation perfusion coefficient (D(*)), perfusion fraction (f) and cerebral blood flow (CBF) in the tumor solid area and the contralateral normal white matter area. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.004DOI Listing
January 2019

[Magnetic resonance imaging study of endolymphatic hydrops based on 3D-FLAIR sequence after single-dose intravenous gadolinium injection].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):333-337

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To investigate the visualization of endolymph in patients with otogenic vertigo by intravenous administration of single dose of gadolinium contrast agents and magnetic resonance three-dimensional fluid-attenuated inversion recovery sequence (3D-FLAIR MRI), and further assess the extent of endolymphatic hydrops. From Beijing Tongren Hospital of Capital Medical University between October 2017 and June 2018, 30 patients (16 males, 14 females) with unilateral otogenic vertigo were involved in this study, with the age of 30 to 68 years, mean age of (53±10) years. Eight hours after intravenous administration of single dose (0. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.003DOI Listing
January 2019

[Functional lateralization of major Chinese language cortex for presurgical evaluation in neurosurgery].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):329-332

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

To investigate the functional lateralization of major Chinese language cortex in patients with cerebral arteriovenous malformation (AVM) in dominant hemispheric via functional magnetic resonance imaging (fMRI). Nine right-handed normal volunteers and fourteen patients with cerebral AVM in dominant hemisphere diagnosed in Beijing Tiantan Hospital between December 2017 and June 2018 were included. Three language tasks (semantic judgment, word reading, and listening comprehension) were applied to activate language areas. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.002DOI Listing
January 2019

[The role of food in prevention and correction of iodine deficiency in the endemic territory].

Vopr Pitan 2018 13;87(5):27-36. Epub 2018 Sep 13.

Industrial University of Tyumen.

Iodine supply remains the global problem due to the wide prevalence and a wide range of clinical manifestations in all age groups of population. However, iodine deficiency is a nutritional deficiency and the solution of this problem lies in the organization of rational nutrition of the population. The purpose of this study was to examine the food features of the population of the mild iodine-deficient region from the standpoint of adequacy of iodine sufficiency. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10050DOI Listing
September 2018

[The study of the metabolism of iodotyrosines included in the iodized milk protein in rats].

Vopr Pitan 2018 11;87(3):12-17. Epub 2018 May 11.

The Fund for the Development of Science, Moscow.

In the course of evolution in animals and humans, a complex and effective system for providing the body with iodine in the form of various organic and inorganic compounds was developed. The metabolism of inorganic iodine has been studied quite well, in contrast to the mechanism of assimilation of its organic compounds. Among the latter, iodotyrosines, which are part of iodinated milk proteins, are of particular interest. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10037DOI Listing

Inadvertent Rapid Lipid Emulsion Administration.

Isr Med Assoc J 2019 Feb;21(2):129-130

Institute of Gastroenterology, Nutrition, and Liver Disease, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

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February 2019

Bilateral Diaphragmatic Paralysis: A Rare but not to be Neglected Cause of Dyspnea.

Isr Med Assoc J 2019 Feb;21(2):126-129

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel.

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February 2019

Immunoglobulin G4-Related Disease Presenting with Clinical Similarity to Churg-Strauss Syndrome.

Isr Med Assoc J 2019 Feb;21(2):124-125

Department of Internal Medicine, Meir Medical Center, Kfar Saba, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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February 2019

Ultrasound-Guided Botulinum Toxin Injections into the Salivary Glands for the Treatment of Drooling.

Isr Med Assoc J 2019 Feb;21(2):116-119

Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Drooling is the unintentional loss of saliva from the mouth, usually caused by poor coordination of the swallowing mechanism. It is commonly seen in patients with chronic neurologic disorders, such as Parkinson's disease, amyotrophic lateral sclerosis (ALS), cerebral palsy, and stroke, as well as in patients with cognitive impairment and dementia.

Objectives: To evaluate the efficacy and safety of ultrasound-guided botulinum toxin injections into the parotid and submandibular salivary glands for the treatment of drooling. Read More

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February 2019

Hospitalization for Respiratory Syncytial Virus Bronchiolitis in the Palivizumab Prophylaxis Era: Need for Reconsideration of Preventive Timing and Eligibility.

Isr Med Assoc J 2019 Feb;21(2):110-115

Department of Pediatrics A, Schneider Children's Medical Center, Petah Tikva, Israel.

Background: Respiratory syncytial virus (RSV)-related bronchiolitis is a common cause of morbidity in young infants. The recommendations for its passive prevention by palivizumab are currently under intensive debate.

Objectives: To elucidate the optimal prevention strategy by studying the morbidity of RSV disease under the current recommendations for palivizumab prophylaxis in Israel. Read More

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February 2019

Nationwide Survey of Intratympanic Steroids for the Management of Sudden Sensorineural Hearing Loss.

Isr Med Assoc J 2019 Feb;21(2):105-109

Department of Otolaryngology - Head and Neck Surgery, Western Galilee Medical Center, Nahariya, Israel.

Background: The currently accepted treatment for idiopathic sudden sensorineural hearing loss (ISSHL) is systemic steroids as first-line and intratympanic steroids as salvage therapy. Intratympanic (IT) treatment is applied worldwide in many different ways with no universally accepted protocol.

Objectives: To present the current disparity in ISSHL management and to discuss the necessity for establishing a common national protocol. Read More

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February 2019

Ga-PSMA PET/CT Staging of Newly Diagnosed Intermediate- and High-Risk Prostate Cancer.

Isr Med Assoc J 2019 Feb;21(2):100-104

Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Ga-prostate-specific membrane antigen positron emission tomography/computerized tomography (Ga-PSMA PET/CT) is part of the initial workup of patients with intermediate and high-risk prostate cancer provided by the Israeli national health services.

Objectives: To assess the incidence of metastatic spread in consecutive patients with newly diagnosed cancer, and the potential added value of Ga-PSMA PET/CT to the staging imaging algorithm.

Methods: Patients with newly diagnosed intermediate- and high-risk prostate cancer were referred for initial staging by Ga-PSMA PET/CT between May 2016 and April 2017. Read More

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February 2019

Hyperchloremia and Diuresis in Children Undergoing Scoliosis Surgery: A Retrospective Cohort Study.

Isr Med Assoc J 2019 Feb;21(2):94-99

Division of Anesthesiology, Critical Care and Pain Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Hyperchloremia is frequent in adult surgical patients and is associated with renal dysfunction. Studies in surgical pediatric patients are lacking.

Objectives: To identify both the incidence of postoperative hyperchloremia in children undergoing surgery for idiopathic and non-idiopathic scoliosis, and the association of postoperative hyperchloremia with intraoperative fluid management and postoperative diuresis. Read More

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February 2019

Maternal and Neonatal Complications of Pregnant Women with Mitral Stenosis.

Isr Med Assoc J 2019 Feb;21(2):88-93

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.

Background: Rheumatic mitral stenosis (MS) is a relatively rare diagnosis in the developed countries and its treatment during pregnancy is challenging due to hemodynamic changes. With the demographic changes due to recent waves of immigration an increase in the prevalence of rheumatic heart disease is expected.

Objectives: To evaluate maternal and neonatal complications in patients with mitral stenosis. Read More

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February 2019

Unilateral Renal Agenesis Diagnosed on Early Prenatal Trans-Vaginal Scans.

Isr Med Assoc J 2019 Feb;21(2):85-87

Department of Obstetrics and Gynecology, Rambam Medical Center, affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Unilateral renal agenesis is a rare finding. There are no large-scale studies reporting this finding in early pregnancy.

Objectives: To evaluate the incidence of unilateral renal agenesis (URA) and of associated anomalies diagnosed by early prenatal trans-vaginal sonography. Read More

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February 2019

Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019

Case-Control Retrospective Study of Child Sexual Abuse History among Psychiatric Consultations in a General Hospital Emergency Room.

Isr Med Assoc J 2019 Feb;21(2):77-81

Department of Consultation and Liaison Psychiatry, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: A history of childhood sexual abuse (CSA) has been linked to a variety of physical and psychiatric illnesses, including ischemic heart disease and post-traumatic stress disorder (PTSD).

Objectives: To determine the prevalence of past CSA and re-traumatization among hospital psychiatric consultations and to determine whether a CSA group in a hospital setting shared characteristics with community samples described in the literature.

Methods: We divided 228 consecutive psychiatric consultations into two groups. Read More

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February 2019

Inhibition of endothelial Progenitor Cells Inhibition in the first 24 hours of an Acute Ischemic Cerebrovascular Event.

Isr Med Assoc J 2019 Feb;21(2):71-76

Department of Medicine, Padeh Medical Center, Poriya, Israel.

Background: Endothelial progenitor cells may have a role in ongoing endothelial repair. Impaired mobilization or depletion of these cells may contribute to progression of vascular disease. Our hypothesis was that endothelial progenitor cells would be suppressed in patients with acute cerebrovascular event based on our previous study that found severe endothelial dysfunction in those patients. Read More

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February 2019

Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex.

Neuropsychopharmacol Rep 2019 Feb 16. Epub 2019 Feb 16.

Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

Aims: The molecular and cellular mechanisms underlying the antidepressant effects of fluoxetine in the brain are not fully understood. Emerging evidence has led to the hypothesis that chronic fluoxetine treatment induces dematuration of certain types of mature neurons in rodents. These studies have focused on the properties of typical molecular and/or electrophysiological markers for neuronal maturation. Read More

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http://dx.doi.org/10.1002/npr2.12048DOI Listing
February 2019

Circle of Willis variations in migraine patients with ischemic stroke.

Brain Behav 2019 Feb 16:e01223. Epub 2019 Feb 16.

Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine.

Materials And Methods: Participants were recruited from the prospective Dutch acute Stroke Study. Read More

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http://dx.doi.org/10.1002/brb3.1223DOI Listing
February 2019

Mesenteric adipose tissue B lymphocytes promote local and hepatic inflammation in non-alcoholic fatty liver disease mice.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Gastroenterology, Peking University People's Hospital, Beijing, P.R. China.

Mesenteric adipose tissue (MAT) inflammation is associated with non-alcoholic fatty liver disease (NAFLD), and immune cells play pivotal roles in the inflammation of adipose tissue. Here, we investigated the roles of MAT B lymphocytes in NAFLD. Mice fed with high-fat diet (HFD) and normal diet (ND) were killed in time gradients (4, 8 and 12 weeks). Read More

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http://dx.doi.org/10.1111/jcmm.14232DOI Listing
February 2019

The latest progress on miR-374 and its functional implications in physiological and pathological processes.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Non-coding RNAs (ncRNAs) have been emerging players in cell development, differentiation, proliferation and apoptosis. Based on their differences in length and structure, they are subdivided into several categories including long non-coding RNAs (lncRNAs >200nt), stable non-coding RNAs (60-300nt), microRNAs (miRs or miRNAs, 18-24nt), circular RNAs, piwi-interacting RNAs (26-31nt) and small interfering RNAs (about 21nt). Therein, miRNAs not only directly regulate gene expression through pairing of nucleotide bases between the miRNA sequence and a specific mRNA that leads to the translational repression or degradation of the target mRNA, but also indirectly affect the function of downstream genes through interactions with lncRNAs and circRNAs. Read More

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http://dx.doi.org/10.1111/jcmm.14219DOI Listing
February 2019

Risk factors and self-perception for facial aging among Nepalese population.

J Cosmet Dermatol 2019 Feb 17. Epub 2019 Feb 17.

Department of Dermatology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Background: Facial appearance has increasing importance to individuals and women, in particular. Till date, there are no reports of the extrinsic factors influencing skin aging in Nepalese population.

Objectives: To assess the risk factors and self-perception for facial aging in Nepalese population. Read More

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http://dx.doi.org/10.1111/jocd.12885DOI Listing
February 2019

Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC-derived extracellular vesicles (hUCMSC-EVs) in peripheral nerve regeneration, however, remains unknown. Read More

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http://dx.doi.org/10.1111/jcmm.14190DOI Listing
February 2019

Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

This study investigates the effect of local oestrogen therapy (LET) on the expression of proteins participating in collagen/elastin biogenesis and immune markers in vaginal tissues of post-menopausal women with severe pelvic organ prolapse (POP). Vaginal biopsies were collected from the anterior vaginal wall of informed and consented 52 post-menopausal women with severe POP undergoing total hysterectomy. Twenty-nine of the 52 women were treated with LET (in the form of vaginal oestrogen cream or tablet), while the remaining 23 untreated patients served as the controls. Read More

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http://dx.doi.org/10.1111/jcmm.14199DOI Listing
February 2019

Contemporary Concise Review 2018: Lung cancer and pleural disease.

Respirology 2019 Feb 16. Epub 2019 Feb 16.

Department of Respiratory Medicine, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1111/resp.13499DOI Listing
February 2019

Nutrition and its role in human evolution.

J Intern Med 2019 Feb 17. Epub 2019 Feb 17.

Vice Chancellor and Dean for Agriculture and Life Sciences, Texas A&M AgriLife, College Station, TX, USA.

Our understanding of human evolution has improved rapidly over recent decades, facilitated by large-scale cataloguing of genomic variability amongst both modern and archaic humans. It seems clear that the evolution of the ancestors of chimpanzees and hominins separated 7-9 million years ago with some migration out of Africa by the earlier hominins; Homo sapiens slowly emerged as climate change resulted in drier, less forested African conditions. The African populations expanded and evolved in many different conditions with slow mutation and selection rates in the human genome, but with much more rapid mutation occurring in mitochondrial DNA. Read More

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http://dx.doi.org/10.1111/joim.12878DOI Listing
February 2019

Potential role of Anitschkow cells in cardiovascular disease in human and veterinary medicine: A review of the literature.

Anat Histol Embryol 2019 Feb 17. Epub 2019 Feb 17.

Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy.

Anitschkow cells (AC) are a peculiar type of stromal cells observed in myocardium, cardiac valves and coronary vessels wall whose origin, characterization and role remain controversial. In human heart, they represent a histological hallmark of Aschoff nodules in rheumatic fever, but they have also been observed in other myocardial pathologies. Firstly, they have been considered a myocyte-derived cells, but light microscopy, immunohistochemical and ultrastructural studies pointed out that a macrophagic/histiocytic origin cannot be excluded. Read More

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http://dx.doi.org/10.1111/ahe.12433DOI Listing
February 2019

Vertebral heart size in healthy Australian cattle dog.

Anat Histol Embryol 2019 Feb 17. Epub 2019 Feb 17.

Department of Veterinary Medicine, Agroveterinary Sciences Center, State University of Santa Catarina (CAV / UDESC), Lages, Brazil.

The vertebral heart score or size (VHS) measurement is routinely used to provide a more objective measurement of cardiomegaly in dogs. However, breed or body conformation can influence the VHS. To assess the specific VHS for the Australian Cattle Dog, left-to-right lateral, right-to-left lateral, dorsoventral and ventrodorsal thoracic radiographs from 20 individuals free from cardiac and pulmonary disease were obtained. Read More

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http://dx.doi.org/10.1111/ahe.12434DOI Listing
February 2019
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