68 results match your criteria Journal of Medical Devices [Journal]


A Hand-Held Device to Apply Instrument-Assisted Soft Tissue Mobilization at Targeted Compression Forces and Stroke Frequencies.

J Med Device 2019 Mar 4;13(1):0145041-145045. Epub 2018 Dec 4.

Department of Mechanical and Biomedical Engineering, Boise State University, 1910 University Drive, Boise, ID 83725-2085

Instrument-assisted soft tissue mobilization (IASTM) is a manual therapy technique that is commonly used to treat dysfunctions in ligaments and other musculoskeletal tissues. The objective of this study was to develop a simple hand-held device that helps users accurately apply targeted compressive forces and stroke frequencies during IASTM treatments. This portable device uses a force sensor, tablet computer, and custom software to guide the application of user-specified loading parameters. Read More

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http://dx.doi.org/10.1115/1.4041696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298531PMC
March 2019
2 Reads

Advances in Diagnostic Methods for Zika Virus Infection.

J Med Device 2018 Dec 5;12(4):0408021-4080211. Epub 2018 Nov 5.

Department of Computer Engineering and Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL 33431.

The Zika virus (ZIKV) is one of the most infamous mosquito-borne flavivirus on recent memory due to its potential association with high mortality rates in fetuses, microcephaly and neurological impairments in neonates, and autoimmune disorders. The severity of the disease, as well as its fast spread over several continents, has urged the World Health Organization (WHO) to declare ZIKV a global health concern. In consequence, over the past couple of years, there has been a significant effort for the development of ZIKV diagnostic methods, vaccine development, and prevention strategies. Read More

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http://medicaldevices.asmedigitalcollection.asme.org/article
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http://dx.doi.org/10.1115/1.4041086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298530PMC
December 2018
16 Reads

Children and Adults With Rare Diseases Need Innovative Medical Devices.

J Med Device 2018 Sep 13;12(3):0347011-347018. Epub 2018 Jul 13.

Office of Orphan Products Development, Food and Drug Administration, 10903 New Hampshire Avenue, WO Building 32, Suite 5295, Silver Spring, MD 20993.

Rare diseases (RD) affect approximately 30 million Americans, half of whom are children. This study is the first to comprehensively evaluate their medical device needs via a survey of physicians. The study sought to identify and document the presumed unmet diagnostic and therapeutic device needs for RD management; clarify the magnitude of the potential unmet need; and generate meaningful data to inform medical device stakeholders. Read More

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http://medicaldevices.asmedigitalcollection.asme.org/article
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http://dx.doi.org/10.1115/1.4040489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123063PMC
September 2018
11 Reads

Optimizing Design With Extensive Simulation Data: A Case Study of Designing a Vacuum-Assisted Biopsy Tool.

J Med Device 2018 Jun 4;12(2):0210071-210077. Epub 2018 May 4.

Mem. ASME Department of Mechanical Engineering, University of Minnesota, 111 Church St SE, Minneapolis, MN 55455

Design by Dragging (DBD) [1] is a virtual design tool, which displays three-dimensional (3D) visualizations of many simulation results obtained by sampling a large design space and ties this visual display together with a new user interface. The design space is explored through mouse-based interactions performed directly on top of the 3D data visualizations. Our previous study [1] introduced the realization of DBD with a simplistic example of biopsy needle design under a static bending force. Read More

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http://dx.doi.org/10.1115/1.4040043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056196PMC

A Novel Macroscale Acoustic Device for Blood Filtration.

J Med Device 2018 Mar 19;12(1):0110081-110087. Epub 2018 Jan 19.

College of Pharmacy, Western New England University, 1215 Wilbraham Road, Springfield, MA 01119

Retransfusion of a patient's own shed blood during cardiac surgery is attractive since it reduces the need for allogeneic transfusion, minimizes cost, and decreases transfusion related morbidity. Evidence suggests that lipid micro-emboli associated with the retransfusion of the shed blood are the predominant causes of the neurocognitive disorders. We have developed a novel acoustophoretic filtration system that can remove lipids from blood at clinically relevant flow rates. Read More

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http://dx.doi.org/10.1115/1.4038498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816246PMC
March 2018
3 Reads

The Role of Computational Modeling and Simulation in the Total Product Life Cycle of Peripheral Vascular Devices.

J Med Device 2017 23;11(2). Epub 2017 Jan 23.

Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993.

The total product life cycle (TPLC) of medical devices has been defined by four stages: discovery and ideation, regulatory decision, product launch, and postmarket monitoring. Manufacturers of medical devices intended for use in the peripheral vasculature, such as stents, inferior vena cava (IVC) filters, and stent-grafts, mainly use computational modeling and simulation (CM&S) to aid device development and design optimization, supplement bench testing for regulatory decisions, and assess postmarket changes or failures. For example, computational solid mechanics and fluid dynamics enable the investigation of design limitations in the ideation stage. Read More

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http://dx.doi.org/10.1115/1.4035866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823268PMC
January 2017
7 Reads

Integrating Cadaver Needle Forces Into a Haptic Robotic Simulator.

J Med Device 2018 Mar 5;12(1):0145011-145015. Epub 2017 Dec 5.

Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA 16802

Accurate force simulation is essential to haptic simulators for surgical training. Factors such as tissue inhomogeneity pose unique challenges for simulating needle forces. To aid in the development of haptic needle insertion simulators, a handheld force sensing syringe was created to measure the motion and forces of needle insertions. Read More

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http://dx.doi.org/10.1115/1.4038562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747952PMC
March 2018
3 Reads

Development and Feasibility of a Robotic Laparoscopic Clipping Tool for Wound Closure and Anastomosis.

J Med Device 2018 Mar 22;12(1):0110051-110056. Epub 2017 Nov 22.

Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Health System, 111 Michigan Avenue, NW, Washington, DC 20010

This paper reports the design, development, and initial evaluation of a robotic laparoscopic clipping tool for single manipulator wound closure and anastomosis (tubular reconnection). The tool deploys biodegradable clips and clasps with the goal of (i) integrating grasping and suturing into a single device for single hand or manipulator use, (ii) applying the equivalent of interrupted sutures without the need of managing suture thread, and (iii) allowing for full six degrees-of-freedom (DOFs) laparoscopic control when mounted on a robot arm. The specifications, workflow, and detailed design of the robotic laparoscopic tool and injection molded bio-absorbable T shaped clip and locking clasp are reported. Read More

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http://dx.doi.org/10.1115/1.4038335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747951PMC
March 2018
1 Read

Design and Evaluation of a Robotic Device for Automated Tail Vein Cannulations in Rodent Models.

J Med Device 2017 Dec 16;11(4):0410081-410087. Epub 2017 Oct 16.

Paul and Mary Monroe Distinguished Professor Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854

Preclinical testing in rodent models is a ubiquitous part of modern biomedical research and commonly involves accessing the venous bloodstream for blood sampling and drug delivery. Manual tail vein cannulation is a time-consuming process and requires significant skill and training, particularly since improperly inserted needles can affect the experimental results and study outcomes. In this paper, we present a miniaturized, robotic medical device for automated, image-guided tail vein cannulations in rodent models. Read More

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http://dx.doi.org/10.1115/1.4038011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676643PMC
December 2017
5 Reads

Design and Fabrication of a Low-Cost Three-Dimensional Bioprinter.

J Med Device 2017 Dec 7;11(4):0410011-410019. Epub 2017 Aug 7.

Department of Mechanical Engineering, Louisiana State University, 2508 P.F. Taylor Hall, Baton Rouge, LA 70803

Three-dimensional (3D) bioprinting offers innovative research vectors for tissue engineering. However, commercially available bioprinting platforms can be cost prohibitive to small research facilities, especially in an academic setting. The goal is to design and fabricate a low-cost printing platform able to deliver cell-laden fluids with spatial accuracy along the X, Y, and Z axes of 0. Read More

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http://dx.doi.org/10.1115/1.4037259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572984PMC
December 2017
11 Reads

Effects of Sterilization on Shape Memory Polyurethane Embolic Foam Devices.

J Med Device 2017 Sep 28;11(3):0310111-310119. Epub 2017 Jun 28.

Biomedical Engineering, Texas A&M University, College Station, TX 77843; Shape Memory Medical, Inc., Santa Clara, CA 95054

Polyurethane shape memory polymer (SMP) foams have been developed for various embolic medical devices due to their unique properties in minimally invasive biomedical applications. These polyurethane materials can be stored in a secondary shape, from which they can recover their primary shape after exposure to an external stimulus, such as heat and water exposure. Tailored actuation temperatures of SMPs provide benefits for minimally invasive biomedical applications, but incur significant challenges for SMP-based medical device sterilization. Read More

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http://dx.doi.org/10.1115/1.4037052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572968PMC
September 2017
4 Reads

Finite Element Analysis of the Implantation Process of Overlapping Stents.

J Med Device 2017 Jun 3;11(2):0210101-210109. Epub 2017 May 3.

Bioengineering Program, Lehigh University, Bethlehem, PA 18015.

Overlapping stents are widely used in vascular stent surgeries. However, the rate of stent fractures (SF) and in-stent restenosis (ISR) after using overlapping stents is higher than that of single stent implantations. Published studies investigating the nature of overlapping stents rely primarily on medical images, which can only reveal the effect of the surgery without providing insights into how stent overlap influences the implantation process. Read More

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http://dx.doi.org/10.1115/1.4036391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472852PMC
June 2017
9 Reads

Design of a Magnetic Resonance Imaging Guided Magnetically Actuated Steerable Catheter.

J Med Device 2017 Jun 3;11(2):0210041-2100411. Epub 2017 May 3.

Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106

This paper presents design optimization of a magnetic resonance imaging (MRI) actuated steerable catheter for atrial fibrillation ablation in the left atrium. The catheter prototype, built over polymer tubing, is embedded with current-carrying electromagnetic coils. The prototype can be deflected to a desired location by controlling the currents passing through the coils. Read More

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http://dx.doi.org/10.1115/1.4036095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467027PMC
June 2017
4 Reads

The Role of Simulation in the Design of a Semi-Enclosed Tubular Embolus Retrieval.

J Med Device 2017 Jun 3;11(2):0210011-210017. Epub 2017 May 3.

MicroPort Endovascular (Shanghai) Co., Ltd., 3399 Kangxin Road, Shanghai 201318, China.

A numerical analysis of a semi-enclosed tubular mechanical embolus retrieval device (MERD) for the treatment of acute ischemic stroke (AIS) is presented. In this research, the finite element analysis (FEA) methodology is used to evaluate mechanical performance and provide suggestions for optimizing the geometric design. A MERD fabricated from nickel-titanium alloy (Nitinol) tubing is simulated and analyzed under complex in vivo loading conditions involving shape-setting, crimping, deployment, and embolus retrieval. Read More

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http://dx.doi.org/10.1115/1.4036286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472853PMC
June 2017
21 Reads

Statistical Shape Modeling for Cavopulmonary Assist Device Development: Variability of Vascular Graft Geometry and Implications for Hemodynamics.

J Med Device 2017 Jun 3;11(2). Epub 2017 May 3.

Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science & Great Ormond Street Hospital for Children.

Patients born with a single functional ventricle typically undergo three-staged surgical palliation in the first years of life, with the last stage realizing a cross-like total cavopulmonary connection (TCPC) of superior and inferior vena cavas (SVC and IVC) with both left and right pulmonary arteries, allowing all deoxygenated blood to flow passively back to the lungs (Fontan circulation). Even though within the past decades more patients survive into adulthood, the connection comes at the prize of deficiencies such as chronic systemic venous hypertension and low cardiac output, which ultimately may lead to Fontan failure. Many studies have suggested that the TCPC's inherent insufficiencies might be addressed by adding a cavopulmonary assist device (CPAD) to provide the necessary pressure boost. Read More

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http://dx.doi.org/10.1115/1.4035865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417365PMC
June 2017
13 Reads

Hydraulic Robotic Surgical Tool Changing Manipulator.

J Med Device 2017 Mar 16;11(1):0110081-110086. Epub 2017 Jan 16.

Department of Surgery, University of Nebraska Medical Center, 986245 Nebraska Medical Center, Omaha, NE 68198

Natural orifice transluminal endoscopic surgery (NOTES) is a surgical technique to perform "scarless" abdominal operations. Robotic technology has been exploited to improve NOTES and circumvent its limitations. Lack of a multitasking platform is a major limitation. Read More

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http://dx.doi.org/10.1115/1.4035548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395910PMC
March 2017
4 Reads

RIP: A Novel Respiratory Inductance Plethysmography Monitor.

J Med Device 2017 Mar 24;11(1):0110101-110106. Epub 2017 Jan 24.

Department of Biomedical Research and Center for Pediatric Lung Research, Nemours/Alfred I. duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803 e-mail: 

Objective pulmonary function (PF) evaluation is essential for the diagnosis, monitoring, and management of many pediatric respiratory diseases as seen in the emergency room, intensive care, and outpatient settings. In this paper, the development and testing of a new noninvasive PF instrument, pneuRIP, which utilizes respiratory inductance plethysmography (RIP) are discussed. The pneuRIP hardware includes a small circuit board that connects to the RIP bands and measures and wirelessly transmits the band inductance data to any designated wirelessly connected tablet. Read More

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http://dx.doi.org/10.1115/1.4035546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318692PMC
March 2017
12 Reads

Particulate Release From Nanoparticle-Loaded Shape Memory Polymer Foams.

J Med Device 2017 Mar 16;11(1):0110091-110099. Epub 2017 Jan 16.

Biomedical Engineering, Texas A&M University, College Station, TX 77843; Shape Memory Medical, Inc., Santa Clara, CA 95054 e-mail: 

Highly porous, open-celled shape memory polymer (SMP) foams are being developed for a number of vascular occlusion devices. Applications include abdominal aortic and neurovascular aneurysm or peripheral vascular occlusion. A major concern with implanting these high surface area materials in the vasculature is the potential to generate unacceptable particulate burden, in terms of number, size, and composition. Read More

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http://dx.doi.org/10.1115/1.4035547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253671PMC
March 2017
7 Reads

Novel Device For Removal of Blot Clot Obstructions in Drainage Tubes.

J Med Device 2017 Mar 21;11(1):0145041-145043. Epub 2016 Dec 21.

Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905 e-mail: 

Medical drains frequently become obstructed requiring removal or re-intervention. Currently, there is no widely accepted practice for maintaining drain patency. A simple device to remove obstructions from medical drains may have significant benefit. Read More

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http://medicaldevices.asmedigitalcollection.asme.org/article
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http://dx.doi.org/10.1115/1.4035128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188855PMC
March 2017
8 Reads

Design, Fabrication, and Testing of a Needle-Sized Wrist for Surgical Instruments.

J Med Device 2017 Mar 21;11(1):0145011-145019. Epub 2016 Dec 21.

Associate Professor Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37212 e-mail: 

This paper presents a miniature wrist that can be integrated into needle-sized surgical instruments. The wrist consists of a nitinol tube with asymmetric cutouts that is actuated by a single tendon to provide high distal curvature. We derive and experimentally validate kinematic and static models for the wrist and describe several prototype wrists, illustrating the straightforward fabrication and scalability of the design. Read More

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http://dx.doi.org/10.1115/1.4034575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188854PMC
March 2017
3 Reads

Disposable Fluidic Actuators for Miniature In-Vivo Surgical Robotics.

J Med Device 2017 Mar 21;11(1):0110031-110038. Epub 2016 Dec 21.

Mem. ASME Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, W342 Nebraska Hall, Lincoln, NE 68588-0526 e-mail: 

Fusion of robotics and minimally invasive surgery (MIS) has created new opportunities to develop diagnostic and therapeutic tools. Surgical robotics is advancing from externally actuated systems to miniature in-vivo robotics. However, with miniaturization of electric-motor-driven surgical robots, there comes a trade-off between the size of the robot and its capability. Read More

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http://dx.doi.org/10.1115/1.4035005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188852PMC
March 2017
4 Reads

Designing an Affordable Wire Navigation Surgical Simulator.

J Med Device 2016 Sep 1;10(3). Epub 2016 Aug 1.

Department of Orthopaedics and Rehabilitation, 2181 Westlawn, The University of Iowa, Iowa City, IA 52242.

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http://dx.doi.org/10.1115/1.4033799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129743PMC
September 2016
4 Reads

Liquid Handling Optimization in High-Throughput Biodosimetry Tool.

J Med Device 2016 Dec 31;10(4):0410071-4100710. Epub 2016 Aug 31.

Center for Radiological Research, Columbia University Medical Center, New York, NY 10032.

Due to the need of high-speed and efficient biodosimetric assays for triage and therapy in the event of radiological or nuclear attack, a robotically based automated biodosimetry tool (RABiT) has been developed over the past few years. Adapting the micronucleus assay from filter plates to V-shaped plates presented challenges in the liquid handling, namely, cell splashing out of the V-shaped well plate during the cell harvesting, poor cell distribution on the bottom of the image plate during the dispensing, and cell loss from the image plate during the aspiration in the liquid handling process. Experimental and numerical investigations were carried out to better understand the phenomena and mitigate the problems. Read More

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http://dx.doi.org/10.1115/1.4033600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013425PMC
December 2016
5 Reads

A Virtual Reality Haptic Robotic Simulator for Central Venous Catheterization Training.

J Med Device 2016 Sep 1;10(3):0309371-309372. Epub 2016 Aug 1.

Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, State College, PA 16801.

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http://dx.doi.org/10.1115/1.4033867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196364PMC
September 2016

Velocity-Limiting Control of an Active Handheld Micromanipulator.

J Med Device 2016 Sep 1;10(3):0309441-309442. Epub 2016 Aug 1.

The Robotics Institute, Carnegie Mellon University, Pittsburgh, PA 15213.

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http://dx.doi.org/10.1115/1.4033806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793226PMC
September 2016
1 Read

Evaluation of a Prototype Hybrid Vacuum Pump to Provide Vacuum-Assisted Suspension for Above-Knee Prostheses.

J Med Device 2015 Dec 6;9(4):0445041-445044. Epub 2015 Aug 6.

Northwestern University Prosthetics-Orthotics Center, 680 North Lake Shore Drive, Suite 1100, Chicago, IL 60611 e-mail: 

Vacuum-assisted suspension (VAS) of prosthetic sockets utilizes a pump to evacuate air from between the prosthetic liner and socket, and are available as mechanical or electric systems. This technical note describes a hybrid pump that benefits from the advantages of mechanical and electric systems, and evaluates a prototype as proof-of-concept. Cyclical bench testing of the hybrid pump mechanical system was performed using a materials testing system to assess the relationship between compression cycles and vacuum pressure. Read More

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http://dx.doi.org/10.1115/1.4030507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940611PMC
December 2015
38 Reads

Sensorless Force Sensing for Minimally Invasive Surgery.

J Med Device 2015 Dec 15;9(4):0410121-4101214. Epub 2015 Oct 15.

Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68508 e-mail: 

Robotic minimally invasive surgery (R-MIS) has achieved success in various procedures; however, the lack of haptic feedback is considered by some to be a limiting factor. The typical method to acquire tool-tissue reaction forces is attaching force sensors on surgical tools, but this complicates sterilization and makes the tool bulky. This paper explores the feasibility of using motor current to estimate tool-tissue forces and demonstrates acceptable results in terms of time delay and accuracy. Read More

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http://medicaldevices.asmedigitalcollection.asme.org/article
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http://dx.doi.org/10.1115/1.4031282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844080PMC
December 2015
26 Reads

Design of Novel Mixer and Applicator for Two-Component Surgical Adhesives.

J Med Device 2015 Dec 6;9(4):0450011-450016. Epub 2015 Aug 6.

Department of Biomedical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 e-mail: 

Current mixer and applicator devices on the market are not able to properly and efficiently mix two-component surgical adhesives in small volumes necessary to achieve economic viability. Furthermore, in these devices a significant amount of adhesive is wasted during the application process, as material within the dead space of the mixing chamber must be discarded. We have designed and demonstrated a new active mixer and applicator system capable of rapidly and efficiently mixing two components of an adhesive and applying it to the surgical site. Read More

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http://dx.doi.org/10.1115/1.4030828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574869PMC
December 2015
46 Reads

An On-Site Thermoelectric Cooling Device for Cryotherapy and Control of Skin Blood Flow.

J Med Device 2015 Dec 6;9(4):0445021-445026. Epub 2015 Aug 6.

Fellow ASME Department of Biomedical Engineering, The University of Texas at Austin, 107 West Dean Keeton Street, Austin, TX 78712-1081 e-mail: 

Cryotherapy involves the surface application of low temperatures to enhance the healing of soft tissue injuries. Typical devices embody a remote source of chilled water that is pumped through a circulation bladder placed on the treatment site. In contrast, the present device uses thermoelectric refrigeration modules to bring the cooling source directly to the tissue to be treated, thereby achieving significant improvements in control of therapeutic temperature while having a reduced size and weight. Read More

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http://dx.doi.org/10.1115/1.4029508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574863PMC
December 2015
7 Reads

A Compact, Bone-Attached Robot for Mastoidectomy.

J Med Device 2015 Sep;9(3):0310031-310037

Department of Mechanical Engineering, Vanderbilt University , 2301 Vanderbilt Place , PMB 351592 , Nashville, TN 37235 e-mail: 

Otologic surgery often involves a mastoidectomy, which is the removal of a portion of the mastoid region of the temporal bone, to safely access the middle and inner ear. The surgery is challenging because many critical structures are embedded within the bone, making them difficult to see and requiring a high level of accuracy with the surgical dissection instrument, a high-speed drill. We propose to automate the mastoidectomy portion of the surgery using a compact, bone-attached robot. Read More

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http://dx.doi.org/10.1115/1.4030083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547504PMC
September 2015
3 Reads

Design of Bioimpedance Spectroscopy Instrument With Compensation Techniques for Soft Tissue Characterization.

J Med Device 2015 Jun;9(2):0210011-210018

Mechanical Engineering, University of Michigan , 3001E EECS, 1301 Beal, Ann Arbor, MI 48109 e-mail: 

Bioimpedance spectroscopy (BIS) has shown significant potential in many areas of medicine to provide new physiologic markers. Several acute and chronic diseases are accompanied by changes in intra- and extracellular fluid within various areas of the human body. The estimation of fluid in various body compartments is therefore a simple and convenient method to monitor certain disease states. Read More

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http://dx.doi.org/10.1115/1.4029706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410770PMC
June 2015
2 Reads

A Passive Parallel Master-Slave Mechanism for Magnetic Resonance Imaging-Guided Interventions.

J Med Device 2015 Mar;9(1):0110081-1100811

Professor Department of Radiology, Stanford University , Stanford, CA 94305 e-mail: 

A passive, parallel master-slave mechanism is presented for magnetic resonance imaging (MRI)-guided interventions in the pelvis. The mechanism allows a physician to stand outside the MRI scanner while manipulating a needle inside the bore and, unlike a powered robot, does not place actuators in proximity to the patient. The manipulator combines two parallel mechanisms based on the Delta robot architecture. Read More

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http://dx.doi.org/10.1115/1.4028944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245788PMC
March 2015
3 Reads

Low Cost Magnetic Resonance Imaging-Compatible Stepper Exercise Device for Use in Cardiac Stress Tests.

J Med Device 2014 Dec 19;8(4):0450021-450028. Epub 2014 Aug 19.

Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail: 

Cardiovascular disease is the leading cause of death worldwide. Many cardiovascular diseases are better diagnosed during a cardiac stress test. Current approaches include either exercise or pharmacological stress echocardiography and pharmacological stress magnetic resonance imaging (MRI). Read More

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http://medicaldevices.asmedigitalcollection.asme.org/article
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http://dx.doi.org/10.1115/1.4027343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307773PMC
December 2014
8 Reads

Development and Validation of Endovascular Chemotherapy Filter Device for Removing High-Dose Doxorubicin: Preclinical Study.

J Med Device 2014 Dec 19;8(4):0410081-410088. Epub 2014 Aug 19.

Department of Radiology and Biomedical Imaging, University of California San Francisco , San Francisco, CA 94107.

To develop a novel endovascular chemotherapy filter (CF) able to remove excess drug from the blood during intra-arterial chemotherapy delivery (IAC), thus preventing systemic toxicities and thereby enabling higher dose IAC. A flow circuit containing 2.5 mL of ion-exchange resin was constructed. Read More

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http://dx.doi.org/10.1115/1.4027444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298098PMC
December 2014
22 Reads

Amputee Subject Testing Protocol, Results, and Analysis of a Powered Transtibial Prosthetic Device.

J Med Device 2014 Dec 19;8(4):0410071-410076. Epub 2014 Aug 19.

Department of Mechanical Engineering, Marquette University , Milwaukee, WI 53233 e-mail: 

A powered ankle-foot prothesis and its control system were previously designed and built. To evaluate this prosthesis, amputee subject testing was performed. The testing results are analyzed and compared between the powered prosthesis, passive prosthesis, and able-bodied gait. Read More

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http://dx.doi.org/10.1115/1.4027497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151158PMC
December 2014
3 Reads

A System for Optimizing Medical Device Development Using Finite Element Analysis Predictions.

J Med Device 2014 Jun 28;8(2):0209411-209413. Epub 2014 Apr 28.

Department of Mechanical Engineering , University of Minnesota, 111 Church Street SE , Minneapolis, MN 55455.

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http://dx.doi.org/10.1115/1.4027096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118447PMC
June 2014
3 Reads

Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics and Molecular Dynamics.

J Med Device 2014 Jun 28;8(2):0209541-209542. Epub 2014 Apr 28.

Department of Applied Mathematics and Statistics , Stony Brook University, Stony Brook, NY 11794.

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http://dx.doi.org/10.1115/1.4027347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042554PMC
June 2014
11 Reads
0.620 Impact Factor

Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell-Derived Heart Valve Tissue Engineering.

J Med Device 2013 Dec 5;7(4):0409271-409272. Epub 2013 Dec 5.

Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, University of Texas at Austin , Austin, TX 78712.

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http://dx.doi.org/10.1115/1.4025984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023858PMC
December 2013
3 Reads

The Vascular Model Repository: A Public Resource of Medical Imaging Data and Blood Flow Simulation Results.

J Med Device 2013 Dec 5;7(4):0409231-409231. Epub 2013 Dec 5.

Open Source Medical Software Corporation , San Francisco, CA 94111.

Patient-specific blood flow simulations may provide insight into disease progression, treatment options, and medical device design that would be difficult or impossible to obtain experimentally. However, publicly available image data and computer models for researchers and device designers are extremely limited. The National Heart, Lung, and Blood Institute sponsored Open Source Medical Software Corporation (contract nos. Read More

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http://dx.doi.org/10.1115/1.4025983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023857PMC
December 2013
6 Reads

Hemodynamic Impact of Transcatheter Aortic Valve Deployment Configuration.

J Med Device 2013 Dec 5;7(4):0409221-409222. Epub 2013 Dec 5.

Tissue Mechanics Laboratory, University of Connecticut , Storrs, CT 06269.

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http://dx.doi.org/10.1115/1.4025938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023853PMC
December 2013
3 Reads

Tesla-Based Blood Pump and Its Applications.

J Med Device 2013 Dec 5;7(4):0409171-409172. Epub 2013 Dec 5.

Division of Artificial Organs, Department of Surgery, Penn State College of Medicine , Hershey, PA 17033.

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http://dx.doi.org/10.1115/1.4025982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023856PMC
December 2013
6 Reads

Open Knee: A Pathway to Community Driven Modeling and Simulation in Joint Biomechanics.

Authors:
Ahmet Erdemir

J Med Device 2013 Dec 5;7(4):0409101-409101. Epub 2013 Dec 5.

Computational Biomodeling (CoBi) Core, Department of Biomedical Engineering, Lerner Research Institute , Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1115/1.4025767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023850PMC
December 2013
2 Reads

Blood Damage Quantification in Cardiovascular Flows Through Medical Devices Using a Novel Suspension Flow Method.

J Med Device 2013 Dec 5;7(4):0409091-409091. Epub 2013 Dec 5.

Georgia Institute of Technology and Emory University , Atlanta, GA.

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http://dx.doi.org/10.1115/1.4025838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023852PMC
December 2013
3 Reads

Computational Framework for Determining Patient-Specific Total Knee Arthroplasty Loading.

J Med Device 2013 Dec 5;7(4):0409041-409041. Epub 2013 Dec 5.

Rush University Medical Center , Chicago, IL.

The purpose of this work is to describe a computational framework for predicting total knee arthroplasty loads which are necessary for accurate preclinical testing of implant designs. Inputs required include patient knee joint kinematics, and implant type, size, and physiological alignment. Computational models used in the framework include the calculation of knee joint kinematics and kinetics, prediction of the contact path, a model to determine muscle forces, and a force model to obtain parametric solutions for implant forces. Read More

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http://dx.doi.org/10.1115/1.4025765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023849PMC
December 2013
7 Reads

A Head and Neck Support Device for Inducing Local Hypothermia.

J Med Device 2014 Mar 6;8(1):0110021-110029. Epub 2013 Dec 6.

Department of Mechanical Engineering, University of Minnesota , Minneapolis, MN 55455 ;

The present work describes the design of a device/system intended to induce local mild hypothermia by simultaneously cooling a patient's head and neck. The therapeutic goal is to lower the head and neck temperatures to 33-35 °C, while leaving the core body temperature unchanged. The device works by circulating a cold fluid around the exterior of the head and neck. Read More

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http://dx.doi.org/10.1115/1.4025448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690010PMC
March 2014
7 Reads

Development of a Portable Knee Rehabilitation Device That Uses Mechanical Loading.

J Med Device 2013 Dec 24;7(4):410071-4100710. Epub 2013 Sep 24.

Department of Mechanical Engineering, IUPUI, Indianapolis, IN 46202 e-mail: 

Joint loading is a recently developed mechanical modality, which potentially provides a therapeutic regimen to activate bone formation and prevent degradation of joint tissues. To our knowledge, however, few joint loading devices are available for clinical or point-of-care applications. Using a voice-coil actuator, we developed an electromechanical loading system appropriate for human studies and preclinical trials that should prove both safe and effective. Read More

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http://dx.doi.org/10.1115/1.4024830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792446PMC
December 2013
6 Reads

Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength.

J Med Device 2013 Dec 24;7(4):410051-410056. Epub 2013 Sep 24.

A novel, hand-held Reference Point Indentation (RPI) instrument, measures how well the bone of living patients and large animals resists indentation. The results presented here are reported in terms of Bone Material Strength, which is a normalized measure of how well the bone resists indentation, and is inversely related to the indentation distance into the bone. We present examples of the instrument's use in: (1) laboratory experiments on bone, including experiments through a layer of soft tissue, (2) three human clinical trials, two ongoing in Barcelona and at the Mayo Clinic, and one completed in Portland, OR, and (3) two ongoing horse clinical trials, one at Purdue University and another at Alamo Pintado Stables in California. Read More

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http://dx.doi.org/10.1115/1.4024829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792445PMC
December 2013
21 Reads
17 Citations
0.620 Impact Factor

Self-Expanding Stent and Delivery System for Aortic Valve Replacement.

J Med Device 2012 Dec 1;6(4):410061-410069. Epub 2012 Nov 1.

e-mail: 

Currently, aortic valve replacement procedures require a sternotomy and use of cardiopulmonary bypass (CPB) to arrest the heart and provide a bloodless field in which to operate. A less invasive alternative to open heart surgery is transapical or transcatheter aortic valve replacement (TAVR), already emerging as a feasible treatment for patients with high surgical risk. The bioprosthetic valves are delivered via catheters using transarterial or transapical approaches and are implanted within diseased aortic valves. Read More

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http://dx.doi.org/10.1115/1.4007750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707191PMC
December 2012
4 Reads