42,543 results match your criteria Journal of Maternal-Fetal & Neonatal Medicine [Journal]


Obstetric complications in bipolar disorder: The role of mental health disorders in the risk of caesarean section.

J Affect Disord 2019 Apr 8;252:458-463. Epub 2019 Apr 8.

Perinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clinic, IDIBAPS, Barcelona, Catalonia, Spain; Vulnerability, Psychopathology and Gender research group, Generalitat de Catalunya, Catalonia, Spain.

Background: Women with Bipolar Disorder (BD) during pregnancy present a negative impact on them and their babies' health. Caesarean Section (C-Section) is an intervention to reduce complications associated with childbirth, but it also has risks, including maternal infections, anaesthetic and psychological complications. There are few studies that analyse the C-Section rates in women with BD compared to the general population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183226
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http://dx.doi.org/10.1016/j.jad.2019.04.017DOI Listing
April 2019
2 Reads

Low-dose aspirin reduces hypoxia-induced sFlt1 release via the JNK/AP-1 pathway in human trophoblast and endothelial cells.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Pre-eclampsia (PE) is a serious hypertensive disorder of pregnancy that remains a leading cause of perinatal and maternal morbidity and mortality worldwide. Placental ischemia/hypoxia and the secretion of soluble fms-like tyrosine kinase 1 (sFlt1) into maternal circulation are involved in the pathogenesis of PE. Although low-dose aspirin (LDA) has beneficial effects on the prevention of PE, the exact mechanisms of action of LDA, particularly on placental dysfunction, and sFlt1 release, have not been well investigated. Read More

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http://dx.doi.org/10.1002/jcp.28533DOI Listing

The effect of luteal GnRH antagonist on moderate and severe early ovarian hyperstimulation syndrome during in vitro fertilization treatment: a prospective cohort study.

Arch Gynecol Obstet 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, 100034, People's Republic of China.

Purpose: Ovarian hyperstimulation syndrome (OHSS) is a serious complication of assisted reproductive technology (ART) treatment. However, there are limited data regarding the ability of the luteal GnRH antagonist cetrorelix to reduce the incidence of moderate and severe OHSS, and the mechanism remains unclear. Thus, we designed a study to assess the effectiveness of cetrorelix to prevent early moderate and severe OHSS in high-risk patients undergoing controlled ovarian stimulation for IVF/ICSI. Read More

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http://link.springer.com/10.1007/s00404-019-05163-3
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http://dx.doi.org/10.1007/s00404-019-05163-3DOI Listing
April 2019
1 Read

SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration.

Exp Mol Med 2019 Apr 19;51(4):46. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Bao'an Maternity and Child Health Hospital, Jinan University, Shenzhen, 518100, China.

Rho GTPase-activating protein 26 (ARHGAP26) is a negative regulator of the Rho family that converts the small GTP-binding protein RhoA (GTP-RhoA) to its inactive GDP-bound form and is a putative tumor suppressor gene associated with cell growth and migration. Here, the involvement of ARHGAP26 in ovarian cancer cell proliferation and migration was investigated. In this study, low ARHGAP26 expression was observed in ovarian cancer tissues and was associated with a poor overall survival and higher β-catenin expression in patients with ovarian cancer. Read More

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http://www.nature.com/articles/s12276-019-0236-0
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http://dx.doi.org/10.1038/s12276-019-0236-0DOI Listing
April 2019
1 Read
3.446 Impact Factor

Association Between Changes in Postpartum Weight and Waist Circumference and Changes in Cardiometabolic Risk Factors Among Women With Recent Gestational Diabetes.

Prev Chronic Dis 2019 Apr 18;16:E47. Epub 2019 Apr 18.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts.

Introduction: Women with gestational diabetes mellitus (GDM) have a 30% to 70% risk for developing type 2 diabetes and are at increased risk for cardiovascular disease. Little is known about how anthropometric changes in the first postpartum year modify cardiometabolic risk factors.

Methods: We randomly assigned women in the Balance After Baby study to an intervention group consisting of participation in a web-based lifestyle program or to a control group in which no program was offered. Read More

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http://dx.doi.org/10.5888/pcd16.180308DOI Listing

Longitudinal Analysis Between Maternal Feeding Practices and Body Mass Index (BMI): A Study in Asian Singaporean Preschoolers.

Front Nutr 2019 2;6:32. Epub 2019 Apr 2.

Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore, Singapore.

Bidirectional studies between maternal feeding practices with subsequent child weight are limited, with no studies in Asian populations. In longitudinal analyses, we assessed the directionality of the associations between maternal feeding practices and body mass index (BMI) in preschoolers. Participants were 428 mother child dyads from the GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort. Read More

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https://www.frontiersin.org/article/10.3389/fnut.2019.00032/
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http://dx.doi.org/10.3389/fnut.2019.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454195PMC
April 2019
1 Read

Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality.

Geburtshilfe Frauenheilkd 2019 Apr 26;79(4):382-388. Epub 2019 Feb 26.

Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity. Familial aggregation studies and twin studies suggest a genetic component. Read More

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http://dx.doi.org/10.1055/a-0830-1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461465PMC

Pushing the limits: perinatal outcomes beyond prolonged second stage.

J Matern Fetal Neonatal Med 2019 Apr 18:1-211. Epub 2019 Apr 18.

d Alexandria Health , Boston , USA.

Objective: To evaluate whether extremely prolonged second stage of labor in nulliparous women affects mode of delivery and perinatal outcomes.

Methods: We performed a retrospective cohort study of nulliparous women with singleton gestations and cephalic presentation who reached 10 cm of cervical dilation at gestational age 36 0/7-41 6/7. Women were stratified by epidural status. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609927DOI Listing

Human β-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes.

J Matern Fetal Neonatal Med 2019 Apr 18:1-16. Epub 2019 Apr 18.

a Perinatology Research Branch, Division of Obstetrics and Maternal Fetal Medicine, Division of Intramural Research , Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services , Bethesda , Maryland , and Detroit , Michigan , USA.

Objective: Human β-defensin-3 (HBD-3) has a broad spectrum of antimicrobial activity, and activity and, therefore, plays a central role in host defense mechanisms against infection. Herein, we determined whether HBD-3 was a physiological constituent of amniotic fluid during midtrimester and at term and whether the concentration of this defensin was increased in amniotic fluid of women with spontaneous preterm labor and intact membranes and those with preterm prelabor rupture of membranes (pPROM) with intra-amniotic inflammation or intra-amniotic infection.

Methods: Amniotic fluid was collected from 219 women in the following groups: (1) midtrimester who delivered at term (n = 35); (2) with or without spontaneous labor at term (n = 50); (3) spontaneous preterm labor with intact membranes who delivered at term (n = 29); (4) spontaneous preterm labor with intact membranes who delivered preterm with or without intra-amniotic inflammation or intra-amniotic infection (n = 69); and (5) pPROM with or without intra-amniotic infection (n = 36). Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1597047DOI Listing
April 2019
1 Read

Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycaemia.

J Matern Fetal Neonatal Med 2019 Apr 18:1-261. Epub 2019 Apr 18.

a Department of Obstetrics and Gynecology , Peking University First Hospital , Beijing , China.

Background: Macrosomia at birth is associated with maternal hyperglycaemia and leads to subsequent susceptibility to obesity, abnormal glucose metabolism, hypertension and dyslipidaemia in offspring. Epigenetic reprogramming has been reported to be involved in the development of human diseases caused by suboptimal environmental or nutritional factors. The study was aiming to explore epigenetic mechanism influences on macrosomic infants exposed to intrauterine hyperglycaemia. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609929DOI Listing

Prophylaxis Against Early-onset Group B Streptococcus Infections in Pregnant Women Who Are Allergic to Penicillin.

Clin Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Section of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma.

Group B Streptococcus (GBS) infection remains a significant cause of neonatal morbidity and mortality. Adoption of screening for maternal genital tract colonization and intrapartum antibiotic prophylaxis has significantly reduced early-onset neonatal GBS infections. For women with an allergy to penicillin, recommended agents for prophylaxis have been well-outlined, but compliance with guideline recommendations is poor. Read More

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http://Insights.ovid.com/crossref?an=00003081-900000000-9953
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http://dx.doi.org/10.1097/GRF.0000000000000455DOI Listing
April 2019
1 Read

Dyslipidemia and the role of the adipose tissue in early pregnancy in the BPH/5 mouse model for preeclampsia.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 17. Epub 2019 Apr 17.

Veterinary Clinical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, United States.

Background: The hypertensive pregnancy disorder preeclampsia (PE) is a leading cause of fetal/ maternal morbidity/mortality. Obesity increases the risk to develop PE, presumably via the release of inflammatory mediators from the adipose tissue, but the exact etiology remains largely unknown.

Methods: Using obese PE-like BPH/5 and lean gestational age-matched C57Bl6 mice, we aimed to obtain insight into differential reproductive white adipose tissue (rWAT) gene expression, circulating lipids and inflammation at the maternal-fetal interface during early pregnancy. Read More

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http://dx.doi.org/10.1152/ajpregu.00334.2018DOI Listing
April 2019
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Pakistan Developmental Origins of Health and Disease (DOHaD) Society: addressing the 'DO' component of DOHaD.

J Dev Orig Health Dis 2019 Apr;10(2):141-143

1Department of Obstetrics and Gynaecology, Maternal Fetal Medicine Unit,The Aga Khan University,Karachi,Pakistan.

Adverse intrauterine environment could serve as an important stimulus for postnatal altered health status and for increased susceptibility to long-term non-communicable diseases (NCDs). The notion is now recognized as the Developmental Origins of Health and Disease (DOHaD), which was first proposed by Sir David Barker. Since then, several scientific disciplines have strived to measure the magnitude of the early fetal programming and later risk of diseases. Read More

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http://dx.doi.org/10.1017/S2040174418000636DOI Listing
April 2019
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The relationship between maternal body mass index and pregnancy outcomes in twin compared with singleton pregnancies.

Int J Obes (Lond) 2019 Apr 16. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.

Objecive: Women with twins have an a priori increased risk for many of the complications associated with maternal obesity. Thus, the impact of maternal obesity in twins may differ from that reported in singletons. In addition, given the increased metabolic demands in twin pregnancies, the impact of maternal underweight may be greater in twin compared with singleton gestations. Read More

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http://dx.doi.org/10.1038/s41366-019-0362-8DOI Listing
April 2019
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Derivation and validation of a model predicting the likelihood of vaginal birth following labour induction.

BMC Pregnancy Childbirth 2019 Apr 16;19(1):130. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Background: There is high-quality evidence supporting induction of labour (IOL) for a number of maternal and fetal indications. However, one fifth of inductions fail to result in vaginal births, requiring cesarean deliveries. This has negative clinical, emotional and resource implications. Read More

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https://bmcpregnancychildbirth.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12884-019-2232-8DOI Listing
April 2019
2 Reads

The Accuracy and Cost-Effectiveness of Selective Fetal Echocardiography for the Diagnosis of Congenital Heart Disease in Patients with Pregestational Diabetes Stratified by Hemoglobin A1c.

Am J Perinatol 2019 Apr 16. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio.

Objective:  To evaluate the accuracy of antenatal diagnosis of congenital heart disease (CHD) using screening methods including a combination of elevated hemoglobin A1c, detailed anatomy ultrasound, and fetal echocardiography.

Study Design:  This is a retrospective cohort study of all pregnancies complicated by pregestational diabetes from January 2012 to December 2016. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated for each screening regimen. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685490
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http://dx.doi.org/10.1055/s-0039-1685490DOI Listing
April 2019
1 Read

[Effect of Yunkang Oral Liquid on preventing LPS-induced abortion and regulating immune tolerance in mice].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1227-1232

Zhejiang Chinese Medical University Hangzhou 310053,China.

To investigate the effect of Yunkang Oral Liquid on preventing lipopolysaccharide(LPS)-induced abortion and regulating immune tolerance in mice,sixty normal ICR mice were randomly divided into normal group,model group,Yunkang Oral Liquid high,middle and low dose groups and progesterone group.Abortion model was established by tail vain injection of LPS(0.1μg/mouse)on the 7th day of pregnancy. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181218.002DOI Listing
March 2019
2 Reads

Fetal echocardiographic assessment of the cardiovascular impact of prolonged support in the EXTrauterine Environment for Neonatal Development (EXTEND) system.

Ultrasound Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

Fetal Heart Program, Cardiac Center at The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Objective: EXTrauterine Environment for Neonatal Development (EXTEND) is a system to support ongoing fetal growth and organ development in an extrauterine environment, utilizing a pumpless low resistance oxygenator circuit. The purpose of this study is to evaluate hemodynamics and cardiac function in fetal lambs sustained on the EXTEND system.

Methods: We studied fetal sheep supported for a minimum of 3 weeks on EXTEND. Read More

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http://dx.doi.org/10.1002/uog.20295DOI Listing

Hypothyroidism in Pregnancy.

Authors:
Scott A Sullivan

Clin Obstet Gynecol 2019 Apr 10. Epub 2019 Apr 10.

Department of Obstetrics/Gynecology, Division of Maternal-Fetal Medicine, Medical University of South Carolina, Charleston, South Carolina.

Hypothyroidism in pregnancy is defined as the presence of an elevated thyroid stimulating hormone during gestation, affecting 2% to 3% of the population. Overt hypothyroidism is diagnosed by a decreased FT4, while patients with a normal FT4 are considered to have subclinical disease. Poorly controlled disease is associated with both pregnancy complications and developmental delays in the offspring. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000432DOI Listing
April 2019
2 Reads

Feeding Babies and Bugs.

Authors:
Kjersti Aagaard

Breastfeed Med 2019 Apr;14(S1):S7-S8

Division of Maternal-Fetal Medicine (MFM), Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.

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http://dx.doi.org/10.1089/bfm.2019.0028DOI Listing
April 2019
3 Reads

Heart failure in a post-partum patient with patent ductus arteriosus.

J Obstet Gynaecol 2019 Apr 15:1-2. Epub 2019 Apr 15.

b Department of Cardiology , University La Paz Hospital , Madrid , Spain.

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http://dx.doi.org/10.1080/01443615.2019.1568972DOI Listing

Use of mean platelet volume in the assessment of intrauterine infection in newborns with combined thrombocytopenia and leukopenia at birth.

J Matern Fetal Neonatal Med 2019 Apr 14:1-161. Epub 2019 Apr 14.

a Department of Pediatrics , University of Kansas Medical Center , Kansas City , Kansas , USA.

Objective: Intrauterine stress can be reflected on hematological disturbance at birth. Thrombocytopenia and leukopenia may be a result of exposure to maternal hypertensive disorders but may also indicate fetal inflammatory response to intrauterine infection, prompting empiric antibiotics use during the initial assessment after birth. Emerging data suggest long-term adverse health outcomes associated with antibiotics exposure early in life. Read More

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http://dx.doi.org/10.1080/14767058.2019.1608174DOI Listing
April 2019
1 Read

Challenges in Managing Pregnancy in Underserved Women with Chronic Kidney Disease.

Am J Nephrol 2019 Apr 12;49(5):386-396. Epub 2019 Apr 12.

Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, University of Guadalajara Health Sciences Center, Guadalajara, Mexico,

Background: Chronic kidney disease (CKD) is a global public health problem and is linked to adverse outcomes during pregnancy; the high prevalence of CKD (3-6%) in women of childbearing age is of particular relevance in emerging countries where CKD prevalence is higher and resources are limited. Although CKD is a public health problem in Mexico, there is scant information on outcomes in pregnant CKD women in this country. We report maternal-fetal outcomes in a prospective cohort of poor, CKD pregnant women, and compare results with those of pregnant women without CKD. Read More

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https://www.karger.com/Article/FullText/499964
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http://dx.doi.org/10.1159/000499964DOI Listing
April 2019
2 Reads

Opportunities for hospitals, hospital systems and leadership to improve VTE prophylaxis.

Semin Perinatol 2019 Mar 9. Epub 2019 Mar 9.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6651 Main Street, Suite F420, Houston, Texas.

A sustained increase in the maternal death rate in the U.S. remains one of the most challenging issues of the twenty-first century. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193003
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http://dx.doi.org/10.1053/j.semperi.2019.03.007DOI Listing
March 2019
2 Reads

Quantitative Ultrasound Parameters Based on the Backscattered Echo Power Signal as Biomarkers of Cervical Remodeling: A Longitudinal Study in the Pregnant Rhesus Macaque.

Ultrasound Med Biol 2019 Apr 9. Epub 2019 Apr 9.

Medical Physics Department, University of Wisconsin, Madison, Wisconsin, USA. Electronic address:

Clinical prediction and especially prevention of abnormal birth timing, particularly pre-term, is poor. The cervix plays a key role in birth timing; it first serves as a rigid barrier to protect the developing fetus, then becomes the pathway to delivery of that fetus. Imaging biomarkers to define this remodeling process could provide insights to improve prediction of birth timing and elucidate novel targets for preventive therapies. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.12.004DOI Listing
April 2019
1 Read

How Can Pelvic MRI with Diffusion-Weighted Imaging Help My Pregnant Patient?

Am J Perinatol 2019 Apr 12. Epub 2019 Apr 12.

Division of Abdominal Imaging, Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

The purpose of this review is to explain how diffusion-weighted imaging (DWI) is used during magnetic resonance imaging (MRI) exams in pregnant patients for specific maternal indications, including evaluation of acute pelvic pain, adnexal masses, cancer diagnosis and staging, and morbidly adherent placenta. While ultrasound is often the appropriate initial imaging for evaluating a pregnant patient, MRI can be helpful when a pelvic ultrasound is indeterminate. MRI has advantages in that it does not use ionizing radiation and has shown no known deleterious effects to the fetus. Read More

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http://dx.doi.org/10.1055/s-0039-1685492DOI Listing
April 2019
1 Read

Change in Cervical Length across Pregnancies and Preterm Delivery.

Am J Perinatol 2019 Apr 12. Epub 2019 Apr 12.

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Objective:  To determine whether a decrease in midtrimester cervical length across pregnancies is associated with preterm delivery in a subsequent pregnancy.

Study Design:  This is a cohort study of women who had two consecutive singleton births at the same institution. Midtrimester cervical length change across pregnancies was measured as the difference in centimeters (cm) between cervical lengths using the measurement taken closest to 20 weeks' gestation in each pregnancy. Read More

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http://dx.doi.org/10.1055/s-0039-1685444DOI Listing

Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis.

PLoS Med 2019 Apr 12;16(4):e1002771. Epub 2019 Apr 12.

Department of Obstetrics and Gynaecology, The Royal Women's Hospital, University of Melbourne, Melbourne, Australia.

Background: Infants born preterm compared with infants born at term are at an increased risk of dying and of serious morbidities in early life, and those who survive have higher rates of neurological impairments. It remains unclear whether exposure to repeat courses of prenatal corticosteroids can reduce these risks. This individual participant data (IPD) meta-analysis (MA) assessed whether repeat prenatal corticosteroid treatment given to women at ongoing risk of preterm birth in order to benefit their infants is modified by participant or treatment factors. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002771DOI Listing
April 2019
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Valproic acid stimulates migration of the placenta-derived mesenchymal stem/stromal cell line CMSC29.

Stem Cell Investig 2019 13;6. Epub 2019 Feb 13.

Department of Maternal-Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital, Parkville, Victoria 3052, Australia.

Background: The placenta is an abundant source of mesenchymal stem/stromal cells (MSC), but our understanding of their functional properties remains limited. We previously created a placental-derived chorionic MSC (CMSC) cell line to overcome the difficulties associated with conducting extensive optimization and experimental work on primary cells. The aim of this study was to characterize the migratory behavior of the CMSC29 cell line . Read More

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http://dx.doi.org/10.21037/sci.2019.01.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414337PMC
February 2019
1 Read

Identifying occult maternal malignancies from 1.93 million pregnant women undergoing noninvasive prenatal screening tests.

Genet Med 2019 Apr 12. Epub 2019 Apr 12.

BGI Genomics, BGI-Shenzhen, Shenzhen, Guangdong, China.

Purpose: Multiple chromosomal aneuploidies may be associated with maternal malignancies and can cause failure of noninvasive prenatal screening (NIPS) tests. However, multiple chromosomal aneuploidies show poor specificity and selectivity for diagnosing maternal malignancies.

Methods: This multicenter retrospective analysis evaluated 639 pregnant women who tested positive for multiple chromosomal aneuploidies on initial NIPS test between January 2016 and December 2017. Read More

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http://dx.doi.org/10.1038/s41436-019-0510-5DOI Listing
April 2019
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Iron status and risk factors of iron deficiency among pregnant women in Singapore: a cross-sectional study.

BMC Public Health 2019 Apr 11;19(1):397. Epub 2019 Apr 11.

Department of Obstetrics & Gynaecology, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.

Background: Iron deficiency is the most prevalent nutrient deficiency and the most common cause of anaemia worldwide. Because of the increased iron requirements during pregnancy, iron deficiency can lead to maternal anaemia and reduced newborn iron stores. We examined the proportion and risk factors of iron deficiency among pregnant women in a developed Asian country. Read More

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http://dx.doi.org/10.1186/s12889-019-6736-yDOI Listing
April 2019
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Early maladaptive schemas as predictors of maternal bonding to the unborn child.

BMC Psychol 2019 Apr 11;7(1):23. Epub 2019 Apr 11.

Department of Psychology, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037, Tromsø, Norway.

Background: The quality of an expectant mother's bonding to the fetus has been shown to be associated with important developmental outcomes. Previous studies suggest that bonding quality is predicted by, for example, social support, psychological well-being, and depression. However, little is known regarding the role of maternal cognition in maternal-fetal bonding. Read More

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https://bmcpsychology.biomedcentral.com/articles/10.1186/s40
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http://dx.doi.org/10.1186/s40359-019-0297-9DOI Listing
April 2019
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Quantitative meta-analysis of maternal prenatal salivary cortisol and newborn birthweight does not identify effect of fetal sex.

Psychoneuroendocrinology 2019 Apr 4;106:117-121. Epub 2019 Apr 4.

Department of Community Health Sciences, University of Calgary, 3820 Hospital Drive N.W., Calgary, AB, T2N 4Z6, Canada; Alberta Children's Hospital Research Institute for Child and Maternal Health, Heritage Medical Research Building, 3330 Hospital Drive N.W., Calgary, AB, T2N 4N1, Canada; Department of Paediatrics, University of Calgary, 2888 Shaganappi Trail N.W., Calgary, AB, T3B 6A8, Canada; Department of Psychology, University of Calgary, 2500 University Drive N.W., Calgary, AB, T2N 1N4, Canada.

Background: Heightened concentration of maternal cortisol is a frequently proposed mechanism linking adverse maternal environments with poor birth outcomes, including birth weight. It is commonly hypothesized that prenatal exposures have sexually dimorphic effects on fetal development, however few studies have assessed the effects of fetal sex on the relationship between maternal cortisol and birth outcomes.

Methods: In a previous systematic review and meta-analysis we obtained data from authors of included studies to calculate trimester-specific correlations between maternal prenatal salivary cortisol and newborn birth weight. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530193012
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http://dx.doi.org/10.1016/j.psyneuen.2019.03.036DOI Listing
April 2019
3 Reads

Effect of a High-Fat Diet and Metformin on Placental mTOR Signaling in Mice.

AJP Rep 2019 Apr 9;9(2):e138-e143. Epub 2019 Apr 9.

Division of Gynecologic Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

 This study was aimed to measure the effects of a high-fat diet and metformin on placental mechanistic target of rapamycin (mTOR) signaling in mice.  Pregnant friend virus B (FVB)-strain mice were allocated on embryonic day (e) 0.5 to one of four groups; group 1: control diet (CD, 10% fat) + control treatment (CT), group 2: CD + metformin treatment (MT), group 3: high-fat diet (HFD, 60% fat) + CT, and group 4: HFD + MT. Read More

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http://dx.doi.org/10.1055/s-0039-1683362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456331PMC

Sonographic Estimated Fetal Weight and Cesarean Delivery among Nulliparous Women with Obesity.

AJP Rep 2019 Apr 9;9(2):e127-e132. Epub 2019 Apr 9.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

 This study was aimed to examine the association between having an ultrasound estimate of fetal weight (US-EFW) and mode of delivery among obese women.  A retrospective cohort study of nulliparous women with a body mass index of ≥ 35 kg/m who delivered term singleton gestations. We examined whether having had an US-EFW within 35 days of delivery, or an US-EFW ≥ 90th percentile for gestational age, was associated with intrapartum cesarean delivery. Read More

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http://dx.doi.org/10.1055/s-0039-1684035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456329PMC
April 2019
1 Read

The Perturbation of Infant Gut Microbiota Caused by Cesarean Delivery Is Partially Restored by Exclusive Breastfeeding.

Front Microbiol 2019 26;10:598. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Early establishment of the infant gut microbiome has been attributed to various environmental factors that may influence long-term health. The aim of this study was to determine the single and combined impacts of the delivery mode, feeding pattern and postnatal antibiotic exposure on the initial establishment of infant gut microbiome at 6 weeks postpartum. A cross-sectional study was conducted at a single center in China. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00598
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http://dx.doi.org/10.3389/fmicb.2019.00598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443713PMC
March 2019
6 Reads

Reading Level of Online Patient Education Materials From Major Obstetrics and Gynecology Societies.

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Department of Obstetrics and Gynecology, University of California, San Francisco-Fresno Medical Education Program, Fresno, California.

Objective: To assess whether the readability of online patient education materials provided by eight nationally recognized obstetrics and gynecology societies is in accordance with the recommended 6th-grade reading level outlined by the American Medical Association, National Institute of Health, and United States Department of Health and Human Services.

Methods: An analysis of 410 online patient education materials from the American Association of Gynecologic Laparoscopists, the American College of Obstetricians and Gynecologists, the American Society for Reproductive Medicine, the American Urogynecologic Society, the Association of Reproductive Health Professionals, the Society of Gynecologic Oncology, the Society for Maternal-Fetal Medicine, and Voices for Pelvic Floor Disorders was completed, and the readability scores using the Flesch-Kincaid Grade Level, Flesch Reading Ease, Gunning Fog Scale, and Simple Measure of Gobbledygook readability scales were calculated. These scales are used to assess print and web-based written material across a wide range of medical specialties and are endorsed by the National Institutes of Health. Read More

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http://Insights.ovid.com/crossref?an=00006250-900000000-9775
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http://dx.doi.org/10.1097/AOG.0000000000003214DOI Listing
April 2019
1 Read

Addressing Obstetrics and Gynecology Trainee Burnout Using a Yoga-Based Wellness Initiative During Dedicated Education Time.

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Department of Obstetrics, Gynecology and Women's Health, Saint Louis University, St. Louis, and the Department of Bioinformatics, University of Missouri Kansas City, Kansas City, Missouri.

Objective: To estimate the feasibility of implementing a yoga-based wellness program during training and its influence on burnout, depression, anxiety, stress, and mindfulness among obstetrics and gynecology trainees.

Methods: We conducted a departmental quality improvement initiative consisting of weekly 1-hour yoga classes conducted during protected education time and nutrition and physical challenges for 24 obstetrics and gynecology residents and five maternal-fetal medicine fellows. Participants received a free wrist-worn fitness tracker device to record their activity. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003229DOI Listing

Successful childbirth in a Fontan with protein losing enteropathy.

Cardiol Young 2019 Apr 10:1-2. Epub 2019 Apr 10.

Congenital Heart Center,420 NE Glen Oak Ave, Suite 301, Peoria, IL 61603,USA.

As survival rates and functional status of the adult single ventricle population have grown, some may become pregnant inadvertently or against our advice. The outcomes are often poor, being worse for the fetus/baby rather than the mother with a Fontan circuit. No reports of a successful delivery of a healthy baby to a Fontan mother with protein losing enteropathy were found in the literature. Read More

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http://dx.doi.org/10.1017/S1047951119000246DOI Listing
April 2019
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Clinical application of the dried milk spot method for measuring tocilizumab concentrations in the breast milk of patients with rheumatoid arthritis.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Tokyo, Japan.

Aims: Tocilizumab (TCZ), a humanized anti-interleukin-6 receptor monoclonal antibody, is used to treat rheumatic diseases. There is limited information about the administration of TCZ during lactation. The dried spot method, a simple technique for processing biological samples which involves placement of a drop of specimen onto filter paper, has been used in clinical pharmacology to determine various drug concentrations. Read More

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http://dx.doi.org/10.1111/1756-185X.13557DOI Listing
April 2019
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Lack of Evidence for Time or Dose Relationship between Antenatal Magnesium Sulfate and Intestinal Injury in Extremely Preterm Neonates.

Neonatology 2019 Apr 9;115(4):371-378. Epub 2019 Apr 9.

Division of Neonatology, Pomona Valley Hospital Medical Center, Pomona, California, USA.

Background: Recent studies reported conflicting results on the relationship between antenatal magnesium sulfate (MgSO4) exposure and neonatal intestinal injury. Most studies have not assessed MgSO4 exposure quantitatively and none reported the exposure timing.

Objectives: The aim of this work was to assess whether there is a temporal or dose-dependent relationship between antenatal MgSO4 exposure and intestinal injury in extremely preterm neonates. Read More

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http://dx.doi.org/10.1159/000497412DOI Listing

An extremely severe case of Aicardi-Goutières syndrome 7 with a novel variant in IFIH1.

Eur J Med Genet 2019 Apr 6. Epub 2019 Apr 6.

Division of Neonatology, Center for Maternal-Fetal, Neonatal, and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

We describe herein an extremely severe case of Aicardi-Goutières syndrome 7 (AGS7). The female patient was the daughter of nonconsanguineous parents and developed cardiomegaly, pericardial effusion, splenomegaly, and intracranial calcification during the fetal period. Because her cardiotocogram showed a non-reassuring fetal status, she was delivered at 29 weeks and 4 days of gestation by an emergency cesarean section. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.04.003DOI Listing
April 2019
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Body mass index restrictions in fertility treatment: a national survey of OB/GYN subspecialists.

J Assist Reprod Genet 2019 Apr 8. Epub 2019 Apr 8.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, 48108, USA.

Purpose: To explore the attitudes of reproductive endocrinology and infertility (REI) and maternal-fetal medicine (MFM) subspecialists regarding the necessity and appropriateness of body mass index (BMI) cutoffs for women seeking fertility treatment.

Methods: Members of the Society for Reproductive Endocrinology and Infertility (SREI) and the Society for Maternal Fetal Medicine (SMFM) were invited to participate in a survey querying their knowledge of existing institutional or clinic BMI policies and personal opinions regarding upper and lower BMI cutoffs for a range of fertility treatments, including oral ovulation agents, gonadotropins, and in vitro fertilization.

Results: Respondents included 398 MFMs and 201 REIs. Read More

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http://dx.doi.org/10.1007/s10815-019-01448-3DOI Listing
April 2019
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Germline-Derived Gain-of-Function Variants of Gs-Coding Gene Identified in Nephrogenic Syndrome of Inappropriate Antidiuresis.

J Am Soc Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Departments of Molecular Endocrinology,

Background: The stimulatory G-protein -subunit encoded by exons 1-13 (-Gs) mediates signal transduction of multiple G protein-coupled receptors, including arginine vasopressin receptor 2 (AVPR2). Various germline-derived loss-of-function -Gs variants of maternal and paternal origin have been found in pseudohypoparathyroidism type Ia and pseudopseudohypoparathyroidism, respectively. Specific somatic gain-of-function -Gs variants have been detected in McCune-Albright syndrome and may result in phosphate wasting. Read More

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http://dx.doi.org/10.1681/ASN.2018121268DOI Listing
April 2019
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When pregnancy tames the wolf.

J Exp Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, New York University School of Medicine, New York, NY.

A state of relative immunosuppression exists in normal pregnancy. In this issue of , Hong et al. (https://doi. Read More

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http://dx.doi.org/10.1084/jem.20190378DOI Listing
April 2019
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The association between high-normal blood pressure and the development of preeclampsia in twin pregnancies.

J Matern Fetal Neonatal Med 2019 Apr 9:1-5. Epub 2019 Apr 9.

a Department of Obstetrics , Gynecology, and Reproductive Sciences, Icahn School of Medicine at Mount Sinai , New York , NY , USA.

Objective: We sought to determine if women with twin pregnancies and blood pressure (BP) above the 95th percentile but within normal ranges (i.e. less than 140 systolic and 90 diastolic) are at increased risk of hypertensive disorders of pregnancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1601696DOI Listing
April 2019
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Arterial flow patterns in healthy transitioning near-term neonates.

BMJ Paediatr Open 2019 14;3(1):e000333. Epub 2019 Feb 14.

Libin Cardiovascular Institute of Alberta, University of Calgary, AB, Calgary, AB, Canada.

Objective: Significant haemodynamic changes occur at delivery impacting organ blood flow distribution. We aimed to characterise Doppler indices patterns over time in three different organs (brain, gut and kidney) and test them as measures of vascular resistance.

Design: Observational cohort study. Read More

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http://dx.doi.org/10.1136/bmjpo-2018-000333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422249PMC
February 2019
1 Read

Fully automatic 3D reconstruction of the placenta and its peripheral vasculature in intrauterine fetal MRI.

Med Image Anal 2019 Mar 28;54:263-279. Epub 2019 Mar 28.

BCN MedTech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain; ICREA, Barcelona, Spain.

Recent advances in fetal magnetic resonance imaging (MRI) open the door to improved detection and characterization of fetal and placental abnormalities. Since interpreting MRI data can be complex and ambiguous, there is a need for robust computational methods able to quantify placental anatomy (including its vasculature) and function. In this work, we propose a novel fully-automated method to segment the placenta and its peripheral blood vessels from fetal MRI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13618415183030
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http://dx.doi.org/10.1016/j.media.2019.03.008DOI Listing
March 2019
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Early vs. standard screening and treatment of gestational diabetes in high-risk women - An attempt to determine relative advantages and disadvantages.

Nutr Metab Cardiovasc Dis 2019 Mar 1. Epub 2019 Mar 1.

Diabetes Section, University Hospital of Pisa, Italy.

Background And Aims: Screening for Gestational Diabetes (GDM) is usually recommended between 24 and 28 weeks of pregnancy; however available evidence suggests that GDM may be already present before recommended time for screening, in particular among high-risk women as those with prior GDM or obesity. The purpose of this retrospective study was to evaluate whether early screening (16-18 weeks) and treatment of GDM may improve maternal and fetal outcomes.

Methods And Results: In 290 women at high-risk for GDM, we analyzed maternal and fetal outcomes, according to early or standard screening and GDM diagnosis time. Read More

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http://dx.doi.org/10.1016/j.numecd.2019.02.007DOI Listing
March 2019
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Fetal echocardiography (ECHO) in assessment of structural heart defects in congenital diaphragmatic hernia patients: Is early postnatal ECHO necessary for ECMO candidacy?

J Pediatr Surg 2019 Feb 20. Epub 2019 Feb 20.

Texas Children's Fetal Center, Baylor College of Medicine, Texas Children's Hospital, Houston, TX; Michael E. DeBakey Department of Surgery-Division of Pediatric Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, TX. Electronic address:

Purpose: The purpose of this study was to determine the accuracy of fetal echocardiogram (ECHO) for detecting cardiac structural anomalies that may impact Extracorporeal Membrane Oxygenation (ECMO) candidacy in infants with Congenital Diaphragmatic Hernia (CDH).

Methods: A retrospective review was performed on fetuses with CDH (January 2007-June 2017). Inclusion criteria were inborn and at least one prenatal and postnatal ECHO. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.022DOI Listing
February 2019
6 Reads