Search Our Scientific Publications & Authors

J Liposome Res 2019 Feb 10:1-30. Epub 2019 Feb 10.

b College of pharmaceutical sciences, Zhejiang University , Hangzhou , China.

Multidrug resistance (MDR) is the largest obstacle to the success of chemotherapy. The development of innovative strategies and safe sensitizers are required to overcome MDR. Paclitaxel (PTX) is a widely used chemotherapeutic drug, the application of which has been learn to understand MDR. Read More

J Liposome Res 2019 Feb 10:1-24. Epub 2019 Feb 10.

c College of Pharmaceutical Sciences, Jiangsu University , Zhenjiang 212013 , China.

The aim of this study was to evaluate whether lycopene-loaded liposomes (L-LYC) could interfere with the antitumor efficacy and cardiotoxicity of doxorubicin (DOX). L-LYC were prepared by a thin-film hydration method to overcome the instability, insolubility, and low bioavailability of lycopene. The mean diameter and morphology of the liposomes were determined by dynamic light scattering and transmission electron microscopy, respectively, and then, in vitro cytotoxicity and in vivo antitumor activity were determined to evaluate the effects of L-LYC and their combination with DOX. Read More

J Liposome Res 2019 Feb 10:1-26. Epub 2019 Feb 10.

b Pharmaceutical Technology Department, Pharmaceutical Industry Division , National Research Centre , El-Bohooth Street , Cairo , Egypt.

This study was aiming to improve the effect of the water insoluble drug, Resveratrol, by encapsulating it in surfactant-based elastic vesicles (SLs). SLs were prepared by thin film hydration method using different ratios of Span 60 (S60) and Edge activators (EAs). The prepared spanlastics (SLs) were subjected to full in-vitro evaluation. Read More

J Liposome Res 2019 Feb 10:1-33. Epub 2019 Feb 10.

a Department of Pharmaceutical Sciences , Babasaheb Bhimrao Ambedkar University (A Central University) , Lucknow , India , 226025.

Mammary gland tumor has the highest incidence rate and mortality in women, worldwide. The present study envisaged a molecularly targeted nanostructured lipid carrier (NLCs) for doxorubicin (Dox) delivery capable of inducing cellular apoptosis in mammary gland tumor. NLCs were prepared utilizing Perilla frutescens oil (54-69% ω3-fatty acid) as liquid lipid to enhance entrapment of Dox through molecular ion pairing. Read More

J Liposome Res 2019 Feb 5:1-32. Epub 2019 Feb 5.

b Department of Pharmacology , National Organization for Drug Control and Research (NODCAR) , Giza , Egypt.

The increasing incidence of venous thromboembolism in paediatric population has stimulated the development of liquid anticoagulant formulations. Thus our goal is to formulate a liquid formulation of poorly-water soluble anticoagulant, Rivaroxaban, for paediatric use and to assess the possibility of its intravenous administration in emergencies. Self-nanoemulsifying drug delivery systems (SNEDDS) were developed and characterized. Read More

J Liposome Res 2019 Jan 22:1-43. Epub 2019 Jan 22.

c Department of Pharmaceutical Biotechnology , School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences , Isfahan , Iran.

The current study aimed to develop PEGylated trimethyl chitosan (TMC) coated emulsomes (EMs) conjugated with octreotide for targeted delivery of sorafenib to hepatocellular carcinoma cells (HCC) of HepG2. Sorafenib loaded TMC coated EMs were prepared by the emulsion evaporation method and characterized concerning particle size, zeta potential, drug encapsulation efficiency and in vitro drug release. Synthesized EMs were then conjugated to octreotide. Read More

J Liposome Res 2019 Jan 11:1-33. Epub 2019 Jan 11.

b Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain Shams University , Cairo , Egypt.

Lycopene, a naturally occurring carotenoid in red-colored fruits, especially tomatoes, has a pivotal role in counteracting the deleterious effect of oxidative stress on periodontal tissues. The aim of the present study is to prepare solid lipid microparticles (SLMs) encapsulating lycopene and to assess their biochemical and clinical effects in the management of chronic periodontitis. Optimization of SLMs was performed by assessing particle size and lycopene entrapment efficiency. Read More

J Liposome Res 2019 Feb 5:1-9. Epub 2019 Feb 5.

a Grupo de Pesquisa em Bioquímica e Toxicologia em Caenorhabditis elegans (GBToxCE), Universidade Federal do Pampa - UNIPAMPA , Uruguaiana , Brazil.

The ethanolic extract obtained from purple pitanga fruit (Eugenia uniflora - PPE) has been previously described by its potential to reduce lipid accumulation in vitro. In this study, we aimed to study this potential in vivo using Caenorhabditis elegans as animal model. Considering the low pH of the extract, its hydrophilic characteristic, its absorption by the medium where the worms are cultivated and the need of a chronic exposure in the worms solid medium, we have loaded liposomes with PPE and investigated its potential for oral administration. Read More

J Liposome Res 2018 Dec 10:1-21. Epub 2018 Dec 10.

a Department of Pharmaceutics , Maratha Mandal's College of Pharmacy , Belagavi , India.

Melanoma is the most deadly and life-threatening form of skin cancer with progressively higher rates of incidence worldwide. The objective of the present investigation is to develop and to statistically optimize and characterize curcumin (CUR) loaded ethosomes for treatment of melanoma. A two factor, three level (3) factorial design approach was employed for the optimization of ethosomes. Read More

J Liposome Res 2018 Dec 10:1-7. Epub 2018 Dec 10.

a Faculty of Pharma-Science, Laboratory of Drug and Gene Delivery Research , Teikyo University , Tokyo , Japan.

It is known that Phosphatidyl choline-Phosphatidyl glycerol mixtures can be used for liposome formulations, making them less leaky than liposomes with only one lipid. We hypothesized that this might also be the case for bubbles, which can be used as ultrasound (US) contrast agents. Therefore, we have compared a series of mixed distearoyl phosphatidylcholine-distearoyl phosphatidylglycerol (DSPC-DPSG) bubbles and with bubbles containing either DSPC or DSPG (and distearoyl ethanolamine-polyethyleneglycol 2000, DSPE-PEG2k). Read More

J Liposome Res 2019 Feb 5:1-11. Epub 2019 Feb 5.

a Therapeutic Targeting Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle , Callaghan , Australia.

Targeted delivery of therapeutics to the uterus is an important goal in the treatment of obstetric complications, such as preterm labour, postpartum hemorrhage, and dysfunctional labour. Current treatment for these obstetric complications is challenging, as there are limited effective and safe therapeutic options available. We have developed a targeted drug delivery system for the uterus by conjugating anti-oxytocin receptor (OTR) antibodies to the surface of PEGylated liposomes (OTR-PEG-ILs). Read More

J Liposome Res 2018 Dec 10:1-14. Epub 2018 Dec 10.

a Pharmaceutical Technology Department, Pharmaceutical industries Research Division , National Research Centre , Dokki, Cairo , Egypt.

Niosomes as drug delivery systems have the ability to decrease drugs' side effects and increase their therapeutic effectiveness. Metformin HCl is an oral antihyperglycemic agent belonging to biguanides. It is the most commonly chosen drug as a startup therapy for patients newly diagnosed with type 2 diabetes. Read More

J Liposome Res 2018 Dec 2:1-10. Epub 2018 Dec 2.

b Department of Pharmaceutics , Marathwada Mitra Mandal's College of Pharmacy , Pune , Maharashtra , India.

The purpose of this research was to develop cubosomal mucoadhesive in situ nasal gel to enhance the donepezil HCl delivery to the brain. Glycerol mono-oleate (GMO) and surfactant poloxamer 407 were used to prepare cubosomes. The developed formulations were characterized for particle size (PS), poly dispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), transmission electron microscopy (TEM), in vitro drug release and in vivo bio-distribution study in blood and brain tissue. Read More

J Liposome Res 2018 Dec 2:1-18. Epub 2018 Dec 2.

a Department of Pharmaceutical Sciences , Babasaheb Bhimrao Ambedkar University , Lucknow 226025 , India.

Hepatic carcinoma (HC) is one of the most prevalent cancers, ranked as the second most common cause of cancer related deaths worldwide. Silymarin (SYL) has been reported for its anticarcinogenic activity against various types of cancer such as prostate, breast, ovary, colon, lung, bladder and liver. Due to poor solubility and low bioavailability SYL lacks satisfactory therapeutic value thus designing a suitable and effective delivery system of SYL can led to improved therapeutic potential. Read More

J Liposome Res 2019 Feb 5:1-8. Epub 2019 Feb 5.

c Department of Dermatology, Faculty of Medicine , Cairo University , Cairo , Egypt.

Acne vulgaris is the most common dermatological disorder affecting millions of individuals. Acne therapeutic solutions include topical treatment with retinoic acid (RA) which showed a good efficacy in treatment of mild and moderate cases. However, the high prevalence of adverse events, such as skin dryness, shedding and skin irritation affects the patient convenience and obstruct the acne treatment. Read More

J Liposome Res 2018 Nov 23:1-4. Epub 2018 Nov 23.

b Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program, Walter Reed Army Institute of Research , 503 Robert Grant Avenue , Silver Spring , MD 20910 , USA.

Liposomes containing cholesterol and monophosphoryl lipid A (such as ALFQ and AS01B) are vaccine adjuvants. During construction of the formulations, addition of QS21 to nano-size (50-100 nm) liposomes resulted in extremely large (up to ∼30 µm) liposomes in ALFQ, but AS01B liposomes remained small nano-vesicles. Here, we show that saturation of phospholipid chains is essential for production of large liposomes by QS21. Read More

J Liposome Res 2018 Nov 23:1-8. Epub 2018 Nov 23.

a Department of Organic and Pharmaceutical Technology , Odessa National Polytechnic University , Odessa , Ukraine.

The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy. We report here, that inclusion of monocyclic terpenoid esters in phospholipid liposomes leads to growth of excimer to monomer ratio (I/I) indicating a decrease of membrane microviscosity. Read More

J Liposome Res 2018 Oct 8:1-34. Epub 2018 Oct 8.

b Bharati Vidyapeeth's College of Pharmacy, Shivaji University , Kolhapur - 416 013 , Maharashtra , India.

The motive behind present work was to discover a solution for overcoming the problems allied with deprived oral bioavailability of salbutamol sulphate (SS) due to its first pass hepatic metabolism, shorter half life and systemic toxicity at high doses. Pulmonary delivery provides alternative route of administration to avoid hepatic metabolism of SS, moreover facilitated diffusion and prolonged retention can be achieved by incorporation into liposomes. Liposomes were prepared by thin film hydration technique using 3 full factorial design and formulation was optimized based on the vesicle size and percent drug entrapment (PDE) of liposomes. Read More

J Liposome Res 2018 Oct 8:1-27. Epub 2018 Oct 8.

b Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde , 161 Cathedral Street , G4 0RE Glasgow , United Kingdom.

RNA interference (RNAi) is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeutics is limited by the development of an effective delivery system, as naked siRNA is unstable and cannot penetrate the cell membrane. Read More

J Liposome Res 2018 Oct 3:1-19. Epub 2018 Oct 3.

b School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou , 450001 , China.

The primary purpose of the present study was to design and optimize a solid lipid nanoparticle (SLN) formulation of the poorly water-soluble drug 2-methoxyestradiol (2-ME) to improve its oral bioavailability and prolong the duration of therapeutic drug level. SLN was modified by amphipathic PEG-PCL (PLN) and then encapsulated in pH-sensitive microparticles (MP) by spray drying technology. Several properties of 2-ME PLN-MP were characterized including particle size, drug loading and drug or PLN release. Read More

J Liposome Res 2018 Nov 23:1-14. Epub 2018 Nov 23.

a Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy , Zagazig University , Zagazig , Egypt.

The current study was conducted to develop vesicular ethosomal gel (ethogel) systems for upgrading the transdermal delivery of anti-hypertensive carvedilol. Ethosomes composed of Phospholipon 100 H, cholesterol, ethanol, and Transcutol P at different ratios, were prepared by thin-film hydration method with sonication. Carvedilol-loaded ethosomes were characterized by microscopic examinations followed by other in-vitro assessments. Read More

J Liposome Res 2018 Sep 20:1-28. Epub 2018 Sep 20.

c Department of Biochemistry, Faculty of Biological Sciences , Tarbiat Modares University , Tehran , Iran.

In recent years there has been much interest in development of multifunctional drug delivery systems. In this work, liposomes that contain doxorubicin (Dox), a potent anticancer drug, and graphene nanosheets (GNS) were prepared. The GNSs have excellent optical properties, such as photoluminescence which enables tracking of the liposomes, high absorption in ultra violet region of electromagnetic spectrum which can be exploited in photodynamic and photothermal therapy, and low toxicity to mammalian cells. Read More

J Liposome Res 2018 Nov 23:1-11. Epub 2018 Nov 23.

a Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy , University of Beni-Suef , Beni-Suef , Egypt.

The oral administration of celecoxib (CLX) is a real problem because of its low aqueous solubility that results in high variability in absorption and its severe adverse effect such as cardiotoxic effects and gastrointestinal toxicity. Self-nanoemulsifying drug delivery systems (SNEDDS) can enhance the poor dissolution and erratic absorption of poorly water-soluble drugs such as CLX. This study was conducted to investigate the potential of SNEDDS to enhance the efficacy of CLX on inflamed mucous tissue and reduce systemic adverse effects by increasing its poor dissolution properties. Read More

J Liposome Res 2018 Nov 13:1-12. Epub 2018 Nov 13.

a Department of Pharmaceutical Technology , National Research Centre , Giza , Egypt.

Bilosomes were developed in order to investigate their efficacy as nanocarriers for transdermal delivery of Tizanidine HCl (TZN), a skeletal muscle relaxant with low oral bioavailability. Full factorial experimental design consisting of 27 combinations was generated to study the effects of surfactant type, surfactant-to-cholesterol ratio and the amount of bile salt on the entrapment efficiency (EE), the vesicle size (VS) and in vitro dissolution of the TZN-loaded bilosomes. The permeation through the stratum cornea was optimized with the vertical diffusion assembly using excised rat skin. Read More

J Liposome Res 2018 Nov 13:1-12. Epub 2018 Nov 13.

b Faculty of Pharmacy, Department of Pharmaceutics and Clinical Pharmacy , Nahda University (NUB) , Beni Suef , Egypt.

Bio-identical progesterone (PRG) is an exogenous female steroidal hormone which is used for treatment of polycystic ovary syndrome (PCOS). However, it suffers from poor bioavailability due to hepatic metabolism and poor solubility. The target of this work was to evaluate and statistically optimize PRG-loaded nanovesicle transethosomes (NVTEs) based in mucoadhesive gel for transvaginal delivery of PRG as potential luteal-phase support. Read More

J Liposome Res 2018 Sep 6:1-11. Epub 2018 Sep 6.

a Laboratory of Biochemistry, Faculty of Veterinary Medicine , University of Thessaly , Karditsa , Greece.

Vitamin A (VA) is an essential nutrient needed in small amounts by humans and supports a wide range of biological actions. Retinol, the most common and most biologically active form of VA has also been found to inhibit peroxidation processes in membranes and it has been widely used as an ingredient with pharmaceutical and nutritional applications. VA is a lipophilic molecule, sensitive to air, oxidizing agents, ultraviolet light and low pH levels. Read More

J Liposome Res 2018 Oct 12:1-11. Epub 2018 Oct 12.

a Department of Pharmaceutics, School of Pharmaceutical Sciences , Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research , Dehardun , India.

Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular carrier containing high ethanol concentrations and offer improved skin permeability and efficient bioavailability due to their structure and composition. Read More

J Liposome Res 2018 Sep 11:1-10. Epub 2018 Sep 11.

a Department of Pharmacy , Birla Institute of Technology and Science (BITS) Pilani , Hyderabad Campus , Hyderabad , India.

Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), monopalmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (MPPC), and different surface active agents. Read More

J Liposome Res 2018 Jul 19:1-27. Epub 2018 Jul 19.

a School of Food Science and Engineering, Engineering Research Center of Bio-Process of Ministry of Education, Hefei University of Technology , Hefei 230009 , Anhui , P. R. China.

The purpose of this study was to optimize the preparation conditions of podophyllotoxin liposomes (PPT-Lips), and to investigate their effects on PC3 cells. PPT-Lips were prepared by using a thin-film dispersion method. In order to achieve maximum drug encapsulation efficiency (EE), the process and formulation variables were optimized by response surface methodology (RSM). Read More

J Liposome Res 2019 Mar 6;29(1):66-72. Epub 2018 Sep 6.

a Department of Biochemistry and Tissue Biology, Institute of Biology , University of Campinas-UNICAMP , Campinas , Brazil.

This study describes the encapsulation of the local anaesthetic lidocaine (LDC) in large unilamellar liposomes (LUV) prepared in a scalable procedure, with hydrogenated soybean phosphatidylcholine, cholesterol and mannitol. Structural properties of the liposomes were assessed by dynamic light scattering, nanoparticle tracking analysis and transmission electron microscopy. A modified, two-compartment Franz-cell system was used to evaluate the release kinetics of LDC from the liposomes. Read More

J Liposome Res 2018 May 10:1-34. Epub 2018 May 10.

a The collage of Pharmacy, Anhui University of Chinese Medicine , Hefei 230012 , China.

Background and Objective The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the anti-cancer efficiency in HepG2 cells. Methods The delivery system was prepared by a two-step method. Read More

J Liposome Res 2018 Apr 24:1-29. Epub 2018 Apr 24.

a School of Health Sciences, Department of Pharmacy, Section of Pharmaceutical Technology, Laboratory of Pharmaceutical Nanotechnology National and Kapodistrian University of Athens , Panepistimioupolis Zografou , 15771 Athens.

The aim of the present study is to investigate the interactions between liposomes and proteins and to evaluate the role of liposomal lipid composition and concentration in the formation of protein corona. Liposomes composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or hydrogenated soybean phosphatidylcholine (HSPC) with 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) (DPPG), 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-3000] (DPPE-PEG 3000), cholesterol (CH) or mixtures of these lipids, were prepared at different concentrations by the thin-film hydration method. After liposomes were dispersed in HPLC-grade water and fetal bovine serum (FBS), their physicochemical characteristics, such as size, size distribution and ζ-potential, were determined using dynamic and electrophoretic light scattering. Read More

J Liposome Res 2019 Mar 19;29(1):86-93. Epub 2018 Apr 19.

a Department of Pharmacy , Wuhan General Hospital of Chinese PLA , Wuhan , China.

This study aimed to develop novel temperature-sensitive liposomes loading paclitaxel (PTX-TSL) and evaluate them in vitro to improve the delivery efficiency and targeting of PTX. K237 peptide was conjugated to the terminal NHS of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[hydroxyl succinimidyl (polyethylene glycol)-(DSPE-PEG-NHS), and K237-modified PTX-TSL (K237-PTX-TSL) was prepared using a film dispersion method. K237-TSL encapsulation with calcein was synthesized and used to determine the cellular uptake of TSL. Read More

J Liposome Res 2019 Mar 19;29(1):94-101. Epub 2018 Apr 19.

a Institute of Pharmacology and Toxicology , National Academy of Medical Science , Kyiv , Ukraine.

The effects of quercetin-loaded liposomes (PCL-Q) and their constituents, that is, free quercetin (Q) and 'empty' phosphatidylcholine vesicles (PCL), on maxi-K channel activity were studied in single mouse ileal myocytes before and after HO-induced oxidative stress. Macroscopic Maxi-K channel currents were recorded using whole-cell patch clamp techniques, while single BK channel currents were recorded in the cell-attached configuration. Bath application of PCL-Q (100 μg/ml of lipid and 3 μg/ml of quercetin) increased single Maxi-K channel activity more than threefold, from 0. Read More

J Liposome Res 2019 Mar 6;29(1):53-65. Epub 2018 Apr 6.

a Department of Medical Biotechnology, Faculty of Medical Sciences , Tarbiat Modares University , Tehran , Iran.

Synergistic effect of combined antibodies targeting distinct epitopes of a particular tumour antigen has encouraged some clinical trial studies and is now considered as an effective platform for cancer therapy. Providing several advantages over conventional antibodies, variable domain of heavy chain of heavy chain antibodies (VH) is now major tools in diagnostic and therapeutic applications. Active targeting of liposomal drugs is a promising strategy, resulting in enhanced binding and improved cytotoxicity of tumour cells. Read More

J Liposome Res 2018 Mar;28(1):1-4

a UCL School of Pharmacy , London , UK.

J Liposome Res 2019 Mar 6;29(1):73-85. Epub 2018 Feb 6.

a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo University , Cairo , Egypt.

Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart their lipid bilayer with ultra-flexibility to trespass SC by high self-optimizing deformability. Read More

J Liposome Res 2019 Mar 8;29(1):44-52. Epub 2018 Jan 8.

a College of Pharmacy , Seoul National University , Seoul , Korea.

Resistance to chemotherapy is a key factor in the inefficacy of various forms of treatments for cancer. In the present study, chemo-resistant proteins, including glucose-regulated protein 78 (GRP78)/clusterin (CLU) targeted 1,2-dioleoyloxy-3-trimethylammoniumpropane (DOTAP) liposomes, were developed as a delivery system for co-delivery of camptothecin (CPT) and GRP78 siRNA/CLU siRNA. Their drug/gene co-deliveries were quantitatively assessed in cancer stem cells (CSC) and MCF-7 cells. Read More

J Liposome Res 2019 Mar 13;29(1):35-43. Epub 2017 Dec 13.

a Department of Pharmaceutics , Jamia Hamdard , New Delhi , India.

Combination therapy of artemether (ART) and lumefantrine (LUM) is well-established for the treatment of uncomplicated malaria worldwide. Nanoliposomes (NLs) encapsulating both drugs were prepared and freeze-dried. The lyophilized nanoliposomes exhibited high entrapment efficiency of artemether (66. Read More

J Liposome Res 2019 Mar 7;29(1):21-34. Epub 2017 Dec 7.

a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Dalian , China.

Brain glioma is one of the most common and devastating intracranial malignancies with a high mortality. Chemotherapy for brain glioma is not ideal due to blood brain barrier (BBB) and multidrug resistance (MDR). The objectives of the present study were to develop a kind of RGD (Arg-Gly-Asp) tripeptide modified vinorelbine plus tetrandrine liposomes to achieve BBB transportation, MDR reversion and glioma cell targeting simultaneously. Read More

J Liposome Res 2019 Mar 4;29(1):10-20. Epub 2017 Dec 4.

a Department of Pharmaceutics , Sinhgad College of Pharmacy , Vadgaon (Bk) , Pune , Maharashtra , India.

The aim of the present research work was to develop, characterize and optimize sertaconazole nitrate (STZN) embedded flexisomes (STZN-FS) to improve the cutaneous anti-fungal activity of STZN. Flexisomes are self-aggregating, flexible, deformable lipidic vesicles possessing an aqueous core. A 3 factorial design was implemented to optimize the effects of the critical material attributes of concentration of phospholipid (X) and edge activator (X) on the critical quality attributes of particle size (Y), entrapment efficiency (Y), and deformability index (Y). Read More

J Liposome Res 2017 Dec 5:1-7. Epub 2017 Dec 5.

d Tamworth Base Hospital , Tamworth , New South Wales , Australia.

Liposome supported peritoneal dialysis is a recently described technique which may eventually be applicable in the clinical scenario of the intoxicated patient. We evaluated the hypothesis that intravenous injection of lipid emulsion (ILE) would augment acidic pH gradient liposome supported peritoneal dialysis (LSPD). Orogastrically amitriptyline dosed rats were treated with either Sodium bicarbonate (NaHCO3) intravenously and standard intraperitoneal dialysate (Group A); NaHCO3 intravenously and LSPD (Group B); or ILE and LSPD (Group C). Read More

J Liposome Res 2019 Mar 20;29(1):1-9. Epub 2017 Nov 20.

a Drug Delivery Disposition and Dynamics , Monash Institute of Pharmaceutical Sciences, Monash University , Melbourne , Australia.

Understanding the effect of liposome size on tendency for accumulation in tumour tissue requires preparation of defined populations of different sized particles. However, controlling the size distributions without changing the lipid composition is difficult, and differences in compositions itself modify distribution behaviour. Here, a commercial microfluidic format as well as traditional methods was used to prepare doxorubicin-loaded liposomes of different size distributions but with the same lipid composition, and drug retention, biodistribution and localization in tumour tissues were evaluated. Read More

J Liposome Res 2017 Sep;27(3):173-179

a Gilead Sciences Inc. , San Dimas , CA , USA.

AmBisome (liposomal amphotericin B) is among the earliest approved liposomal therapeutics, and has been in commercial use since the early 1990s. This review provides examples of non-clinical, regulatory, clinical label expansion, adverse event management, and supply chain control reflecting the real world challenges of a commercial liposomal therapeutic. We review examples of post-approval clinical development in severe lung infections, development of US and European guidance documents around liposomal therapeutics, the creation of a suitable placebo for blinded clinical trials, response to findings of a possible new category of adverse event (what turned out to be pseudohyperphosphatemia), challenges in handling the finished product in a setting with high risk of exposure of the product to temperatures outside of the established label storage conditions, and elements of continuingly increased aseptic processing requirements for manufacturing. Read More

J Liposome Res 2018 Dec 26;28(4):305-314. Epub 2017 Sep 26.

a Department of Human Health Therapeutics , National Research Council Canada , Ottawa , Canada.

Archaeosomes composed of archaeal total polar lipids (TPL) or semi-synthetic analog vesicles have been used as vaccine adjuvants and delivery systems in animal models for many years. Typically administered by intramuscular or subcutaneous injections, archaeosomes can induce robust, long-lasting humoral and cell-mediated immune responses against entrapped antigens and provide protection in murine models of infectious disease and cancer. Herein, we evaluated various archaeosomes for transdermal delivery, since this route may help eliminate needle-stick injuries and needle re-use, and therefore increase patient compliance. Read More

J Liposome Res 2017 Sep 5;27(3):210-220. Epub 2017 Oct 5.

b Molecular Express Inc , Rancho Dominguez , CA , USA.

Given the interest in the ectodomain of the matrix 2 (M2e) channel protein as a target for development of a universal influenza vaccine, we examined the role of the antigen configuration of M2e in generating a protective immune response. A series of M2e mutations and a truncated M2e segment were prepared as a means of controlling the formation of monomer, dimer, and higher order multimeric forms of M2e. Each of these M2e peptides was incorporated into a liposome-based vaccine technology platform previously shown to stimulate a protective response to influenza A infection using M2e as a mixture of monomers, dimers and multimers (L-M2e1-HD/MPL). Read More

J Liposome Res 2018 Dec 5;28(4):331-340. Epub 2017 Oct 5.

a Department of Bioengineering , George Mason University , Fairfax , VA , USA.

Liposomes are one of the most studied nano-delivery systems. However, only a handful of formulations have received FDA approval. Existing liposome synthesis techniques are complex and specialized, posing a major impediment in design, implementation, and mass production of liposome delivery systems as therapeutic agents. Read More

J Liposome Res 2018 Dec 20;28(4):322-330. Epub 2017 Nov 20.

a School of Pharmaceutical Sciences , Shandong University , Jinan , PR China.

First, the SA-TDZA-Lips were prepared by reverse-phase evaporation method. Then, the drug release behaviour was evaluated by dynamic membrane dialysis in vitro and the preliminary safety was evaluated by haemolysis method. Finally, with tedizolid phosphate injection (TDZA-Inj) and tedizolid phosphate loaded liposomes (TDZA-Lips) as the control groups, the pharmacokinetic characteristic and tissues distribution of SA-TDZA-Lips were evaluated after intravenous injection. Read More

J Liposome Res 2018 Dec 26;28(4):315-321. Epub 2017 Sep 26.

a Sunandan Divatia School of Science , NMIMS (Deemed-to-be) University, Biological Sciences, C. B. Patel Research Centre , Mumbai , India.

Drugs used for the treatment and prevention of malaria are often plagued by the problem of development of resistance. This has hampered their therapeutic efficiency and rendered them ineffective for monotherapy. However, if re-packaged and combined properly, many of these neglected anti-malarial drugs can possibly find their way back into the treatment regime. Read More

J Liposome Res 2017 Sep 26;27(3):234-248. Epub 2017 Sep 26.

a Department of Biochemistry and Tissue Biology , Institute of Biology, University of Campinas (UNICAMP) , Campinas , Brazil.

Conventional chemotherapy for leishmaniasis includes considerably toxic drugs and reports of drug-resistance are not uncommon. Liposomal encapsulated drugs appear as an option for the treatment of leishmaniasis, providing greater efficacy for the active and reducing its side effects by promoting superior tissue absorption, favouring drug penetration into the macrophages, and retarding its clearance from the site of action. In this paper, a review on the advances achieved with liposome-based anti-leishmaniasis drug delivery systems is presented. Read More