7,964 results match your criteria Journal of Leukocyte Biology[Journal]


Frontline Science: TLR3 activation inhibits food allergy in mice by inducing IFN-γ Foxp3 regulatory T cells.

J Leukoc Biol 2019 Apr 18. Epub 2019 Apr 18.

Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.

The pathologic feature of food allergy (FA) is the aberrant Th2-biased immune response in the intestine. Regulatory T cells (Tregs) play an important role in the suppression of aberrant immune response. The activities of the TLRs regulate multiple cell functions. Read More

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http://dx.doi.org/10.1002/JLB.3HI0918-348RRDOI Listing

The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication.

J Leukoc Biol 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Ciências Biológicas e Centro de Terapia Celular e Molecular (CTC-Mol), UNIFESP, São Paulo, Brazil.

Trypanossoma cruzi (T. cruzi), the causative protozoan of Chagas disease (CD) invades many cell types, including central nervous system (CNS) cells triggering local lesions and neurological impact. Previous work from our group described NLRP3 inflammasomes as central effectors for the parasite control by macrophages. Read More

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http://dx.doi.org/10.1002/JLB.4AB1118-416RRDOI Listing

A STING to inflammation and autoimmunity.

Authors:
Vijay Kumar

J Leukoc Biol 2019 Apr 16. Epub 2019 Apr 16.

Children's Health Queensland Clinical Unit, School of Clinical Medicine, Faculty of Medicine, Mater Research, University of Queensland, Brisbane, Queensland, Australia.

Various intracellular pattern recognition receptors (PRRs) recognize cytosolic pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Cyclic GMP-AMP synthase (cGAS), a cytosolic PRR, recognizes cytosolic nucleic acids including dsDNAs. The recognition of dsDNA by cGAS generates cyclic GMP-AMP (GAMP). Read More

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http://dx.doi.org/10.1002/JLB.4MIR1018-397RRDOI Listing
April 2019
9 Reads
4.289 Impact Factor

Frontline Science: Aggregated neutrophil extracellular traps prevent inflammation on the neutrophil-rich ocular surface.

J Leukoc Biol 2019 Apr 12. Epub 2019 Apr 12.

Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.

Eye rheum is a physiological discharge, which accumulates at the medial angle of the healthy eye soon after opening in the morning. Microscopic evaluation of eye rheum revealed the presence of viable neutrophils, bacteria, epithelial cells, and particles, aggregated by neutrophil extracellular traps. We observed that in the evening, during eye closure, high C5a recruited neutrophils to the tear film and activated them. Read More

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http://dx.doi.org/10.1002/JLB.HI0718-249RRDOI Listing
April 2019
1 Read

Human cytomegalovirus IL-10 augments NK cell cytotoxicity.

J Leukoc Biol 2019 Apr 9. Epub 2019 Apr 9.

Immunology and Infectious Diseases Program, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.

Human cytomegalovirus (HCMV) persistently infects most of the adult population with periods of productive and latent infection differentially orchestrated by multiple HCMV-encoded gene products. One HCMV gene (UL111a) encodes cmvIL-10, a virokine homologous to human IL (hIL)-10. Although the effects of cmvIL-10 on most human lymphocyte subsets have been extensively studied, its impact on NK cell function was unreported prior to this study. Read More

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http://dx.doi.org/10.1002/JLB.2AB0418-158RRDOI Listing

Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors.

J Leukoc Biol 2019 Apr 9. Epub 2019 Apr 9.

Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan.

Myeloid C-type lectin receptors (CLRs), which consist of an extracellular carbohydrate recognition domain and intracellular signal transducing motif such as the immunoreceptor tyrosine-based activation motif (ITAM) or immunoreceptor tyrosine-based inhibitory motif (ITIM), are innate immune receptors primarily expressed on myeloid lineage cells such as dendritic cells (DCs) and Mϕs. CLRs play important roles in host defense against infection by fungi and bacteria by recognizing specific carbohydrate components of these pathogens. However, these immune receptors also make important contributions to immune homeostasis of mucosa and skin in mammals by recognizing components of microbiota, as well as by recognizing self-components such as alarmins from dead cells and noncanonical non-carbohydrate ligands. Read More

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http://dx.doi.org/10.1002/JLB.2RI0119-031RDOI Listing

The expanding family of noncanonical regulatory cell subsets.

J Leukoc Biol 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

The overwhelming body of research on regulatory lymphocytes has focused on CD4 CD25 Foxp3 T cells (regulatory T cells); however, the last 5 years have witnessed inspiring progress in our understanding of regulatory B cells, regulatory CD8 T cells, regulatory γδ cells, and, more recently, regulatory innate lymphoid cells(ILCregs). This review focuses on these so-called noncanonical regulatory cell subsets. We primarily survey existing information on the phenotype, function, sustaining factors, and clinical value of the 4 best-characterized non-CD4 Foxp3 T regulatory cells. Read More

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http://dx.doi.org/10.1002/JLB.6RU0918-353RRRRDOI Listing

Remote control of T 17 responses: The lung-CNS axis during EAE.

J Leukoc Biol 2019 May 8;105(5):827-828. Epub 2019 Apr 8.

Department of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital Essen, Essen, Germany.

Discussion on remote activation of Th17 cells by lung myeloid cells during EAE. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/JLB.1CE0219-
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http://dx.doi.org/10.1002/JLB.1CE0219-072RDOI Listing
May 2019
1 Read

Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.

J Leukoc Biol 2019 Apr 4. Epub 2019 Apr 4.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

High mobility group box 1 (HMGB1) is a multifunctional nuclear protein, probably known best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. However, HMGB1 has multiple functions that depend on its location in the nucleus, in the cytosol, or extracellularly after either active release from cells, or passive release upon lytic cell death. Movement of HMGB1 between cellular compartments is a dynamic process induced by a variety of cell stresses and disease processes, including sepsis, trauma, and hemorrhagic shock. Read More

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http://dx.doi.org/10.1002/JLB.3MIR1218-497RDOI Listing
April 2019
2 Reads

Neutrophil GM-CSF receptor dynamics in acute lung injury.

J Leukoc Biol 2019 Apr 3. Epub 2019 Apr 3.

Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process essential for signaling. Whereas GM-CSF controls many aspects of neutrophil biology, regulation of GM-CSFRα expression is poorly understood, particularly the role of GM-CSFRα in ligand clearance and whether signaling is sustained despite major down-regulation of GM-CSFRα surface expression. Read More

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http://dx.doi.org/10.1002/JLB.3MA0918-347RDOI Listing
April 2019
2 Reads

Macrophage heterogeneity and plasticity in tuberculosis.

J Leukoc Biol 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, Texas, USA.

Macrophages are the primary host cells for Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), during its intracellular survival in humans. The pathogen has a remarkable capacity to survive within the hostile environment of macrophages. However, primary infection does not result in active TB disease in most individuals. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/JLB.MR0318-0
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http://dx.doi.org/10.1002/JLB.MR0318-095RRDOI Listing
April 2019
6 Reads

Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes.

J Leukoc Biol 2019 Apr 1. Epub 2019 Apr 1.

International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.

Calcineurin (CN) inhibitors are effective clinical immunosuppressants but leave patients vulnerable to potentially fatal fungal infections. This study tested the hypothesis that CN inhibition interferes with antifungal immune defenses mediated by monocytes. We showed that NFAT is expressed by human monocytes, and is activated by exposure to fungal ligands. Read More

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http://dx.doi.org/10.1002/JLB.4VMA0318-138RDOI Listing

Nanoparticles and danger signals: Oral delivery vehicles as potential disruptors of intestinal barrier homeostasis.

J Leukoc Biol 2019 Apr 5. Epub 2019 Apr 5.

School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA.

Gut immune system homeostasis involves diverse structural interactions among resident microbiota, the protective mucus layer, and a variety of cells (intestinal epithelial, lymphoid, and myeloid). Due to the substantial surface area in direct contact with an "external" environment and the diversity of xenobiotic, abiotic, and self-interactions coordinating to maintain gut homeostasis, there is enhanced potential for the generation of endogenous danger signals when this balance is lost. Here, we focus on the potential generation and reception of damage in the gut resulting from exposure to nanoparticles (NPs), common food and drug additives. Read More

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http://dx.doi.org/10.1002/JLB.3MIR1118-414RRDOI Listing
April 2019
1 Read

Pathogenic Entamoeba histolytica, but not Entamoeba dispar, induce neutrophil extracellular trap (NET) formation.

J Leukoc Biol 2019 Mar 26. Epub 2019 Mar 26.

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Amoebiasis is an infection of global importance, caused by the eukaryotic parasite Entamoeba histolytica. Pathogenic E. histolytica is associated worldwide with over a million cases of amoebic dysentery, colitis, and amoebic liver abscess. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/JLB.MA0818-3
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http://dx.doi.org/10.1002/JLB.MA0818-309RRRDOI Listing
March 2019
4 Reads

Adenosine from a biologic source regulates neutrophil extracellular traps (NETs).

J Leukoc Biol 2019 Mar 25. Epub 2019 Mar 25.

Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Neutrophil extracellular traps (NETs) are implicated in autoimmune, thrombotic, malignant, and inflammatory diseases; however, little is known of their endogenous regulation under basal conditions. Inflammatory effects of neutrophils are modulated by extracellular purines such as adenosine (ADO) that is inhibitory or ATP that generally up-regulates effector functions. In order to evaluate the effects of ADO on NETs, human neutrophils were isolated from peripheral venous blood from healthy donors and stimulated to make NETs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/JLB.3VMA0918
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http://dx.doi.org/10.1002/JLB.3VMA0918-374RDOI Listing
March 2019
5 Reads

Below the surface: The inner lives of TLR4 and TLR9.

J Leukoc Biol 2019 Mar 22. Epub 2019 Mar 22.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.

TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by recognizing pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, TLRs activate a signaling cascade that leads to the production of inflammatory mediators. The localization of TLRs, either on the plasma membrane or in the endolysosomal compartment, has been considered to be a fundamental aspect to determine to which ligands the receptors bind, and which transduction pathways are induced. Read More

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http://dx.doi.org/10.1002/JLB.3MIR1218-483RRDOI Listing

Guanylate-binding proteins at the crossroad of noncanonical inflammasome activation during bacterial infections.

J Leukoc Biol 2019 Mar 21. Epub 2019 Mar 21.

Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

The immune system is armed with a broad range of receptors to detect and initiate the elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a diverse range of microbial insults to develop appropriate host response. In that context, noncanonical inflammasome arose as a sensor for Gram-negative bacteria-derived LPS leading to the control of infections. Read More

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http://dx.doi.org/10.1002/JLB.4MR0119-013RDOI Listing

Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells.

J Leukoc Biol 2019 Mar 21. Epub 2019 Mar 21.

Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA.

Inflammatory diseases of the gastrointestinal tract are often associated with microbial dysbiosis. Thus, dietary interactions with intestinal microbiota, to maintain homeostasis, play a crucial role in regulation of clinical disorders such as colitis. In the current study, we investigated if resveratrol, a polyphenol found in a variety of foods and beverages, would reverse microbial dysbiosis induced during colitis. Read More

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http://dx.doi.org/10.1002/JLB.3A1218-476RRDOI Listing

Phosphatase inhibitor PPP1R11 modulates resistance of human T cells toward Treg-mediated suppression of cytokine expression.

J Leukoc Biol 2019 Mar 18. Epub 2019 Mar 18.

Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine Solna, Karolinska University Hospital and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.

Regulatory T cells (Tregs) act as indispensable unit for maintaining peripheral immune tolerance mainly by regulating effector T cells. T cells resistant to suppression by Tregs pose therapeutic challenges in the treatment of autoimmune diseases, while augmenting susceptibility to suppression may be desirable for cancer therapy. To understand the cell intrinsic signals in T cells during suppression by Tregs, we have previously performed a global phosphoproteomic characterization. Read More

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http://dx.doi.org/10.1002/JLB.2A0618-228RDOI Listing
March 2019
4.289 Impact Factor

Augmentation of iNOS expression in myeloid progenitor cells expedites neutrophil differentiation.

J Leukoc Biol 2019 Mar 12. Epub 2019 Mar 12.

Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India.

Neutrophils play important role in immunity and inflammation through diverse mechanisms. Reports from this lab and others have demonstrated involvement of NO in neutrophil adhesion, chemotaxis, bacterial killing, reactive oxygen species generation, neutrophil extracellular traps' formation, and apoptosis. Constitutive expression of iNOS in human neutrophils has also been documented. Read More

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http://doi.wiley.com/10.1002/JLB.1A0918-349RR
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http://dx.doi.org/10.1002/JLB.1A0918-349RRDOI Listing
March 2019
4 Reads

c-Abl kinase regulates neutrophil extracellular trap formation, inflammation, and tissue damage in severe acute pancreatitis.

J Leukoc Biol 2019 Mar 12. Epub 2019 Mar 12.

Department of Clinical Science, Malmö, Section for Surgery, Skåne University Hospital, Lund University, Malmö, Sweden.

Neutrophil extracellular traps (NETs) are involved in acute pancreatitis (AP) but mechanisms controlling NET expulsion in AP are incompletely understood. Herein, we examined the role of c-Abelson (c-Abl) kinase in NET formation and tissue damage in severe AP. AP was induced by taurocholate infusion into pancreatic duct or intraperitoneal administration of l-arginine in mice. Read More

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http://dx.doi.org/10.1002/JLB.3A0618-222RRDOI Listing
March 2019
4.289 Impact Factor

PD-1 modulating Mycobacterium tuberculosis-specific polarized effector memory T cells response in tuberculosis pleurisy.

J Leukoc Biol 2019 Mar 12. Epub 2019 Mar 12.

The Second Affiliated Hospital, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, P. R. China.

Host-pathogen interactions in tuberculosis (TB) should be studied at the disease sites because Mycobacterium tuberculosis (M.tb) is predominantly contained in local tissue lesions. T-cell immune responses are required to mount anti-mycobacterial immunity. Read More

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http://dx.doi.org/10.1002/JLB.MA1118-450RRDOI Listing
March 2019
4 Reads

Biophysical regulation of macrophages in health and disease.

J Leukoc Biol 2019 Mar 12. Epub 2019 Mar 12.

Department of Biomedical Engineering, University of California, Irvine, California, USA.

Macrophages perform critical functions for homeostasis and immune defense in tissues throughout the body. These innate immune cells are capable of recognizing and clearing dead cells and pathogens, and orchestrating inflammatory and healing processes that occur in response to injury. In addition, macrophages are involved in the progression of many inflammatory diseases including cardiovascular disease, fibrosis, and cancer. Read More

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http://doi.wiley.com/10.1002/JLB.MR0318-126R
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http://dx.doi.org/10.1002/JLB.MR0318-126RDOI Listing
March 2019
9 Reads

Cxcl17 mice develop exacerbated disease in a T cell-dependent autoimmune model.

J Leukoc Biol 2019 May 12;105(5):1027-1039. Epub 2019 Mar 12.

Department of Physiology and Biophysics, University of California Irvine, Irvine, California, USA.

CXCL17 is a homeostatic chemokine in the mucosa known to chemoattract dendritic cells and macrophages but can also be expressed elsewhere under inflammatory conditions. Cxcl17 mice have lower numbers of macrophages or dendritic cells in mucosal tissues. CXCL17 is also able to chemoattract suppressor myeloid cells that can recruit regulatory T cells. Read More

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http://doi.wiley.com/10.1002/JLB.3A0918-345RR
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http://dx.doi.org/10.1002/JLB.3A0918-345RRDOI Listing
May 2019
3 Reads

From the "missing self" hypothesis to adaptive NK cells: Insights of NK cell-mediated effector functions in immune surveillance.

J Leukoc Biol 2019 May 8;105(5):955-971. Epub 2019 Mar 8.

Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.

The original discovery of NK cells approximately 40 yr ago was based on their unique capability to kill tumor cells without prior sensitization or priming, a process named natural cytotoxicity. Since then, several studies have documented that NK cells can kill hematopoietic and nonhematopoietic cancer cells. NK cells also recognize and kill cells that have undergone viral infections. Read More

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http://dx.doi.org/10.1002/JLB.MR0618-224RRDOI Listing

PGE -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors.

J Leukoc Biol 2019 Apr 5;105(4):705-717. Epub 2019 Mar 5.

Department of Physiology, HIMSR, Jamia Hamdard, Hamdard Nagar, New Delhi, India.

PGE plays a critical role in angiogenesis, ischemic, and neuro-inflammatory disorders of the brain, which breakdown the blood-brain barrier (BBB). However, the effects of PGE on human brain endothelial cell (HBECs) migration, a key process in the angiogenic response and BBB stability, are not well defined. In this study, we investigated the mechanism of PGE in HBECs migration in vitro. Read More

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http://doi.wiley.com/10.1002/JLB.2A0918-361R
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http://dx.doi.org/10.1002/JLB.2A0918-361RDOI Listing
April 2019
7 Reads

Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis.

J Leukoc Biol 2019 May 5;105(5):1015-1026. Epub 2019 Mar 5.

Organ Care Research and Liver Care Network, Seattle, Washington, USA.

We have previously demonstrated that iron overload in hepatic reticuloendothelial system cells (RES) is associated with severe nonalcoholic steatohepatitis (NASH) and advanced fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Recruited myeloid-derived macrophages have gained a pivotal position as drivers of NASH progression and fibrosis. In this study, we used bone marrow-derived macrophages (BMDM) from C57Bl6 mice as surrogates for recruited macrophages and examined the effect of iron on macrophage polarization. Read More

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http://dx.doi.org/10.1002/JLB.3A0318-108RDOI Listing
May 2019
10 Reads

Synthetic CpG oligonucleotides as potential modulators of neutrophil survival in PAMP-associated inhibition of apoptosis.

J Leukoc Biol 2019 Mar 5. Epub 2019 Mar 5.

Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical Biology, Moscow, Russia.

We studied the effects of a synthetic CpG oligonucleotide (CpG ODN2006) on polymorphonuclear leukocyte (PMNL, neutrophil) survival and oxidant status. CpG ODN2006 showed a dose-dependent effect on the apoptosis of resting neutrophils. Without affecting the viability of resting cells, low concentrations of CpG ODN2006 interfered with Salmonella typhimurium-mediated viability prolongation and increased neutrophil apoptosis to control levels. Read More

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http://dx.doi.org/10.1002/JLB.3MIA1118-435RDOI Listing
March 2019
4.289 Impact Factor

Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming.

J Leukoc Biol 2019 Mar 5. Epub 2019 Mar 5.

Department of Pediatrics, University Clinic Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

It has become increasingly apparent that the biomechanical properties of neutrophils impact on their trafficking through the circulation and in particularly through the pulmonary capillary bed. The retention of polarized or shape-changed neutrophils in the lungs was recently proposed to contribute to acute respiratory distress syndrome pathogenesis. Accordingly, this study tested the hypothesis that neutrophil priming is coupled to morpho-rheological (MORE) changes capable of altering cell function. Read More

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http://doi.wiley.com/10.1002/JLB.MA0718-295RR
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http://dx.doi.org/10.1002/JLB.MA0718-295RRDOI Listing
March 2019
7 Reads

New strategies for treatment of infectious sepsis.

J Leukoc Biol 2019 Mar 1. Epub 2019 Mar 1.

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

In this mini review, we describe the molecular mechanisms in polymicrobial sepsis that lead to a series of adverse events including activation of inflammatory and prothrombotic pathways, a faulty innate immune system, and multiorgan dysfunction. Complement activation is a well-established feature of sepsis, especially involving generation of C5a and C5b-9, along with engagement of relevant receptors for C5a. Activation of neutrophils by C5a leads to extrusion of DNA, forming neutrophil extracellular traps that contain myeloperoxidase and oxidases, along with extracellular histones. Read More

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http://dx.doi.org/10.1002/JLB.4MIR1118-425RDOI Listing
March 2019
2 Reads

Class I myosins: Highly versatile proteins with specific functions in the immune system.

J Leukoc Biol 2019 May 1;105(5):973-981. Epub 2019 Mar 1.

Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.

Connections established between cytoskeleton and plasma membrane are essential in cellular processes such as cell migration, vesicular trafficking, and cytokinesis. Class I myosins are motor proteins linking the actin-cytoskeleton with membrane phospholipids. Previous studies have implicated these molecules in cell functions including endocytosis, exocytosis, release of extracellular vesicles and the regulation of cell shape and membrane elasticity. Read More

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http://dx.doi.org/10.1002/JLB.1MR0918-350RRRDOI Listing
May 2019
1 Read

Microbial killing by NK cells.

J Leukoc Biol 2019 Mar 1. Epub 2019 Mar 1.

Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.

It is now evident that NK cells kill bacteria, fungi, and parasites in addition to tumor and virus-infected cells. In addition to a number of recent publications that have identified the receptors and ligands, and mechanisms of cytotoxicity, new insights are reflected in the reports from researchers all over the world at the 17th Meeting of the Society for Natural Immunity held in San Antonio, TX, USA from May 28 through June 1, 2018. We will provide an overview of the field and discuss how the presentations at the meeting might shape our knowledge and future directions in the field. Read More

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http://dx.doi.org/10.1002/JLB.MR0718-298RDOI Listing
March 2019
3 Reads

Long noncoding RNAs and the regulation of innate immunity and host-virus interactions.

J Leukoc Biol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Immune responses are both pathogen and cell type-specific. The innate arm of immunity is characterized by rapid intracellular signaling cascades resulting in the production of hundreds of antimicrobial effectors that protect the host organism. Long noncoding RNAs have been shown to operate as potent modulators of both RNA and protein function throughout cell biology. Read More

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http://dx.doi.org/10.1002/JLB.3MIR0918-354RDOI Listing
February 2019
1 Read

Human neutrophils activated via TLR8 promote Th17 polarization through IL-23.

J Leukoc Biol 2019 Feb 28. Epub 2019 Feb 28.

Department of Medicine, Section of General Pathology, University of Verona, Verona, Italy.

Human neutrophils contribute to the regulation of inflammation via the generation of a range of cytokines that affect all elements of the immune system. Here, we investigated their ability to express some of the members of the IL-12 family after incubation with TLR8 agonists. Highly pure human neutrophils were thus incubated for up to 48 h with or without R848, or other TLR8 agonists, to then measure the expression levels of transcripts and proteins for IL-12 family member subunits by RNA-seq, reverse transcription quantitative PCR, and ELISA. Read More

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http://dx.doi.org/10.1002/JLB.MA0818-308RDOI Listing
February 2019

Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity.

J Leukoc Biol 2019 Apr 28;105(4):633-644. Epub 2019 Feb 28.

Immunology Section, Department of Medicine, University of Udine, Udine, Italy.

The receptor tyrosine kinase cKit and its ligand stem cell factor are essential for mast cells (MC) development and survival. Strains with mutations affecting the Kit gene display a profound MC deficiency in all tissues and have been extensively used to investigate the role of MC in both physiologic and pathologic conditions. However, these mice present a variety of abnormalities in other immune cell populations that can affect the interpretation of MC-related responses. Read More

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http://doi.wiley.com/10.1002/JLB.4HI1018-390R
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http://dx.doi.org/10.1002/JLB.4HI1018-390RDOI Listing
April 2019
3 Reads

Lactate secreted by cervical cancer cells modulates macrophage phenotype.

J Leukoc Biol 2019 May 27;105(5):1041-1054. Epub 2019 Feb 27.

Department of Immunology, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.

Cervical cancer continues to be a public health problem in developing countries. Previous studies have shown that cervical cancer cells display markers of aerobic glycolysis, indicating that these tumors are likely to secrete lactate. Mostly, lactate is recognized as a molecule capable of suppressing immune responses, through inhibition of T cells, Mϕs, and dendritic cells. Read More

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http://dx.doi.org/10.1002/JLB.3A0718-274RRDOI Listing
May 2019
2 Reads

Dendritic cell-targeted CD40 DNA vaccine suppresses Th17 and ameliorates progression of experimental autoimmune glomerulonephritis.

J Leukoc Biol 2019 Apr 27;105(4):809-819. Epub 2019 Feb 27.

Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.

The CD40-CD40L costimulatory pathway is critical for T cell activation in autoimmune disease. We have previously found that blocking the CD40-CD40L pathway using a dendritic cell-targeted CD40 DNA (DEC-CD40) vaccine prevented the development of Heymann nephritis. In this study, we explored the effect of a DEC-CD40 vaccine in the treatment of experimental autoimmune glomerulonephritis (EAG), an animal model of human Goodpasture's disease induced by antigen α3IV-NC1. Read More

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http://dx.doi.org/10.1002/JLB.5A0818-333RDOI Listing
April 2019
3 Reads
4.289 Impact Factor

Senescent cells: Living or dying is a matter of NK cells.

J Leukoc Biol 2019 Feb 27. Epub 2019 Feb 27.

Department of Molecular Medicine, Sapienza University of Rome,, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

NK cells are lymphocytes of the innate immune system, which are able to deal promptly with stressed cells. Cellular senescence is a cell stress response leading to cell cycle arrest that plays a key role during tissue homeostasis and carcinogenesis. In this review, how senescent cells trigger an immune response and, in particular, the ability of NK cells to recognize and clear senescent cells are discussed. Read More

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http://dx.doi.org/10.1002/JLB.MR0718-299RDOI Listing
February 2019
1 Read

Chemokine-triggered microtubule polymerization promotes neutrophil chemotaxis and invasion but not transendothelial migration.

J Leukoc Biol 2019 Apr 25;105(4):755-766. Epub 2019 Feb 25.

Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

Microtubules (MTs) are critically involved in the transport of material within cells, but their roles in chemotactic leukocyte motility and effector functions are still obscure. Resting neutrophils contain few MTs assembled in an MT organizing center (MTOC) behind their multilobular nuclei. Using a probe of real-time tubulin polymerization, SiR-tubulin, we found that neutrophils elongated their MTs within minutes in response to signals from the two prototypic chemotactic peptides, CXCL1 and fMLP. Read More

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http://dx.doi.org/10.1002/JLB.3A1118-437RRDOI Listing
April 2019
8 Reads

NK cell immune responses differ after prime and boost vaccination.

J Leukoc Biol 2019 May 22;105(5):1055-1073. Epub 2019 Feb 22.

CEA, Université Paris Sud 11, INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT, IBFJ, CEA, Fontenay-aux-Roses, France.

A better understanding of innate responses induced by vaccination is critical for designing optimal vaccines. Here, we studied the diversity and dynamics of the NK cell compartment after prime-boost immunization with the modified vaccinia virus Ankara using cynomolgus macaques as a model. Mass cytometry was used to deeply characterize blood NK cells. Read More

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http://doi.wiley.com/10.1002/JLB.4A1018-391RR
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http://dx.doi.org/10.1002/JLB.4A1018-391RRDOI Listing
May 2019
12 Reads

MASTers of neutrophil homeostasis.

Authors:
Mihaela Gadjeva

J Leukoc Biol 2019 Apr 22;105(4):629-631. Epub 2019 Feb 22.

Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/JLB.4CE0119-008RDOI Listing
April 2019
1 Read

CRTAM NK cells endowed with suppressor properties arise in leukemic bone marrow.

J Leukoc Biol 2019 May 21;105(5):999-1013. Epub 2019 Feb 21.

Unidad de Investigación Médica en Enfermedades Oncológicas, UMAE Hospital Oncología, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Due to their increasing rates of morbidity and mortality, childhood malignancies are considered a global health priority, with acute lymphoblastic leukemias (ALLs) showing the highest incidence worldwide. Control of malignant clone emergence and the subsequent normal-leukemic hematopoietic cell out-competition require antitumor monitoring mechanisms. Investigation of cancer surveillance innate cells may be critical to understand the mechanisms contributing in either disease progression or relapse, and to promote displacement of leukemic hematopoiesis by the normal counterpart. Read More

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http://dx.doi.org/10.1002/JLB.MA0618-231RDOI Listing
May 2019
2 Reads

Regulation of leukocyte function by citric acid cycle intermediates.

J Leukoc Biol 2019 Feb 21. Epub 2019 Feb 21.

Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle intermediates target vital cellular functions of the innate immune system. Succinate, itaconate, citrate, and fumarate have been shown to mediate or regulate important myeloid cell functions during infection and inflammation. Read More

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http://dx.doi.org/10.1002/JLB.3MIR1118-415RDOI Listing
February 2019
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Viral CD229 (Ly9) homologs as new manipulators of host immunity.

J Leukoc Biol 2019 May 21;105(5):947-954. Epub 2019 Feb 21.

Immunology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.

The signaling lymphocytic activation molecule family (SLAMF) of receptors plays crucial roles during innate and adaptive immune responses. The SLAMF member CD229 (Ly9, SLAMF3) is a homophilic receptor predominantly expressed on the surface of B and T cells. CD229 acts as a cosignaling molecule, regulating lymphocyte homoeostasis and activation. Read More

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http://dx.doi.org/10.1002/JLB.2MR1018-413RDOI Listing

Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy.

J Leukoc Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA.

Human NK cell antitumor activities involve Ab-dependent cell-mediated cytotoxicity (ADCC), which is a key mechanism of action for several clinically successful tumor-targeting therapeutic mAbs. Human NK cells exclusively recognize these Abs by the Fcγ receptor CD16A (FcγRIIIA), one of their most potent activating receptors. Unlike other activating receptors on NK cells, CD16A undergoes a rapid down-regulation in expression by a proteolytic process following NK cell activation with various stimuli. Read More

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http://dx.doi.org/10.1002/JLB.2MR1218-501RDOI Listing
February 2019

Human liver-derived CXCR6 NK cells are predominantly educated through NKG2A and show reduced cytokine production.

J Leukoc Biol 2019 Feb 19. Epub 2019 Feb 19.

Research Department Virus Immunology, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

NK cells have been implicated to affect the outcome of numerous liver diseases. In particular, members of the killer-cell Ig-like receptor (KIR) family, predominantly expressed by NK cells, have been associated with the outcome of hepatitis C virus infection and clearance of hepatocellular carcinoma. Inhibitory KIRs tune NK cell function through interaction with HLA class I, a process termed education. Read More

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http://dx.doi.org/10.1002/JLB.1MA1118-428RDOI Listing
February 2019
2 Reads

Unraveling the host's immune response to infection: Seeing is believing.

J Leukoc Biol 2019 Feb 18. Epub 2019 Feb 18.

University of Calgary Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.

It has long been appreciated that understanding the interactions between the host and the pathogens that make us sick is critical for the prevention and treatment of disease. As antibiotics become increasingly ineffective, targeting the host and specific bacterial evasion mechanisms are becoming novel therapeutic approaches. The technology used to understand host-pathogen interactions has dramatically advanced over the last century. Read More

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http://dx.doi.org/10.1002/JLB.4RI1218-503RDOI Listing
February 2019
2 Reads

HIV infection modulates IL-1β response to LPS stimulation through a TLR4-NLRP3 pathway in human liver macrophages.

J Leukoc Biol 2019 Apr 18;105(4):783-795. Epub 2019 Feb 18.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

IL-1β is an important mediator of innate inflammatory responses and has been shown to contribute to liver injury in a number of etiologies. HIV patients have increased necroinflammation and more rapid fibrosis progression in chronic liver injury compared to non-HIV-infected patients. As the resident liver macrophage is critical to the IL-1β response to microbial translocation in chronic liver disease, we aim to examine the impact of HIV-1 and LPS stimulation on the IL-1β response of the resident hepatic macrophages. Read More

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http://dx.doi.org/10.1002/JLB.4A1018-381RDOI Listing
April 2019
2 Reads

Monocyte heterogeneity and functions in cancer.

J Leukoc Biol 2019 Feb 18. Epub 2019 Feb 18.

La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functions that contribute to both pro- and antitumoral immunity, including phagocytosis, secretion of tumoricidal mediators, promotion of angiogenesis, remodeling of the extracellular matrix, recruitment of lymphocytes, and differentiation into tumor-associated macrophages and dendritic cells. Read More

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http://dx.doi.org/10.1002/JLB.4RI0818-311RDOI Listing
February 2019
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Danger signals in oral cavity-related diseases.

J Leukoc Biol 2019 Feb 18. Epub 2019 Feb 18.

Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, USA.

The oral cavity is a unique environment containing teeth juxtaposed with soft tissues, all of which are constantly bathed in microbial products and host-derived factors. While microbial dysbiosis in the oral cavity clearly leads to oral inflammatory disease, recent advances find that endogenous danger-associated molecular patterns (DAMPs) released from oral and salivary tissue also contribute to the progression of inflammatory and autoimmune disease, respectively. In contrast, DAMPs produced during oral fungal infection actually promote the resolution of infection. Read More

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http://dx.doi.org/10.1002/JLB.4MIR1118-439RDOI Listing
February 2019
1 Read