114,231 results match your criteria Journal of Laryngology & Otology[Journal]


Toward Tissue-engineering of Nasal Cartilages.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA, 92697-2715, USA. Electronic address:

Nasal cartilage pathologies are common; for example, up to 80% of people are afflicted by deviated nasal septum conditions. Because cartilage provides the supportive framework of the nose, afflicted patients suffer low quality of life. To correct pathologies, graft cartilage is often required. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.025DOI Listing
February 2019

The MR Imaging Appearance of Endoscopic Endonasal Skull Base Defect Reconstruction Using Free Mucosal Graft.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Division of Otolaryngology, Albany Medical Center, Albany, New York, 12208, U.S.A.

Objective: At our institution, skull base reconstruction using a free mucosal graft from the nasal cavity floor has been the standardized technique after pituitary adenoma resection via transsellar approach. This study describes the expected appearance of the reconstruction on postoperative MRI scans and assesses its integrity and impact on the sinonasal cavity.

Methods: Fifty patients were selected, and their EMR were reviewed for postoperative course, SNOT-22 scores, and nasal endoscopy reports. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.010DOI Listing
February 2019

The Predictive Role of Intra-Operative Visual Evoked Potentials (VEP) in Visual Improvement After Endoscopic Pituitary Tumor Resection in Large and Complex Tumors: Description and Validation of a Method.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Background: With the advent of extensive endoscopic approaches for pituitary tumors there has also been an increase in surgery for larger and more complex tumors. Intraoperative manipulation during endoscopic resection of sellar tumors poses potential risk in postoperative visual function in this tumor population.

Objective: This study proposes a method of accurate intraoperative monitoring of Visual Evoked Potentials (VEPs) and its role in predicting visual function outcomes. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.278DOI Listing
February 2019

Nasal microbial composition and chronic otitis media with effusion: A case-control study.

PLoS One 2019 22;14(2):e0212473. Epub 2019 Feb 22.

Department of Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand.

Objectives: Chronic otitis media with effusion (COME) in children can cause prolonged hearing loss, which is associated with an increased risk of learning delays and behavioural problems. Dispersal of bacterial pathogens from the nasal passages to the middle ear is implicated in COME. We sought to determine whether there is an association between nasal microbial composition and COME in children. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212473PLOS
February 2019

Drug-induced sleep endoscopy-directed adenotonsillectomy in pediatric obstructive sleep apnea with small tonsils.

Authors:
Jie Chen Shan He

PLoS One 2019 22;14(2):e0212317. Epub 2019 Feb 22.

Department of Otolaryngology, Shanghai Children's Medical Center Affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.

The study aims to examine drug-induced sleep endoscopy (DISE) in the decision-making process of pediatric obstructive sleep apnea (OSA) patients with small tonsils. This was a retrospective study of children who underwent awake flexible endoscopy, DISE, and adenoidectomy with/without tonsillectomy at the Shanghai Children's Medical Center between 03/2015 and 12/2016. Tonsillectomy was performed for tonsillar obstruction found by DISE. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212317PLOS
February 2019

3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia.

Laryngoscope 2019 Feb 22. Epub 2019 Feb 22.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.

Objectives/hypothesis: To report the clinical safety and efficacy of three-dimensional (3D)-printed, patient-specific, bioresorbable airway splints in a cohort of critically ill children with severe tracheobronchomalacia.

Study Design: Case series.

Methods: From 2012 to 2018, 15 subjects received 29 splints on their trachea, right and/or left mainstem bronchi. Read More

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http://dx.doi.org/10.1002/lary.27863DOI Listing
February 2019

Add-on probiotics in patients with persistent allergic rhinitis: A randomized crossover clinical trial.

Laryngoscope 2019 Feb 22. Epub 2019 Feb 22.

Department of Otolaryngology, Guilan University of Medical Sciences, Rasht, Iran.

Objectives: Current medications for allergic rhinitis (AR) may have undesirable side effects that could affect quality of life (QoL). Probiotics could be an alternative in these patients. The aim of this study was to assess the impact of add-on probiotics on symptoms and QoL of patients. Read More

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http://dx.doi.org/10.1002/lary.27858DOI Listing
February 2019

Is there a Threshold that Triggers Cortical Arousals in Obstructive Sleep Apnea.

Sleep 2019 Feb 22. Epub 2019 Feb 22.

Pulmonary, Critical Care and Sleep Division. University of California at San Diego, CA, United States.

Study Objectives: To determine whether there is a consistent epiglottic pressure value that predicts respiratory arousal from sleep.

Methods: 31 patients with obstructive sleep apnea underwent overnight polysomnography while instrumented with an epiglottic catheter to measure airway pressures. Nadir epiglottic pressures during respiration events (obstructive apneas/hypopneas) terminated with or without arousals were compared. Read More

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http://dx.doi.org/10.1093/sleep/zsz047DOI Listing
February 2019

Post-operative complications of salvage total laryngectomy forpost-radiotherapy recurrent laryngeal cancer using pectoralis major myocutaneous flaps.

Acta Otolaryngol 2019 Feb 22:1-5. Epub 2019 Feb 22.

a Department of Otolaryngology, Head and Neck Surgery , Tokyo Medical University , Shinjuku-ku , Tokyo , Japan.

Background: Salvage surgery for laryngeal cancer recurring after radiotherapy is difficult and complications readily occur. Our institution has adopted the pharyngeal interposition graft (PIG) using a pectoralis major myocutaneous (PMMC) flap, which has copious blood flow, for preventing post-irradiation pharyngocutaneous fistula.

Aims/objectives: The purpose of this study was to examine the incidence of post-operative complications of salvage total laryngectomy (STL) using the PMMC flap for post-radiotherapy recurrent laryngeal cancer at our institution. Read More

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http://dx.doi.org/10.1080/00016489.2018.1532108DOI Listing
February 2019

Prospective multi-center study on expansion sphincter pharyngoplasty.

Acta Otolaryngol 2019 Feb 22:1-4. Epub 2019 Feb 22.

d Department of Otolaryngology , Asia Sleep Centre, Paragon Medical Centre , Singapore.

Background And Objective: The aim of this study was to demonstrate the long-term effectiveness of Expansion Sphincter Pharyngoplasty (ESP) as a standalone surgical treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) patients through a prospective multi-center study.

Material And Methods: A prospective non-comparative multicenter study of patients suffering from OSHAS selected after drug-induced sleep endoscopy, with ESP as standing alone procedure was performed. Inclusion criteria were lateral collapse on oropharynx and preoperative AHI between 5 and 70. Read More

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http://dx.doi.org/10.1080/00016489.2018.1533992DOI Listing
February 2019

Evolution of self-perceived swallowing function, tongue strength and swallow-related quality of life during radiotherapy in head and neck cancer patients.

Head Neck 2019 Feb 14. Epub 2019 Feb 14.

Department of Otolaryngology and Head and Neck Surgery - Rehabilitation Center for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium.

Background: Radiation-associated-dysphagia is a serious side effect of radiotherapy (RT) for head and neck cancer (HNC).

Methods: Seventy-six patients had a weekly prospective follow-up from baseline until one week post-RT. Combined mixed model analysis (n = 43) determined the evolution of self-perceived swallowing function, isometric tongue strength (MIP), tongue strength (TS) during swallowing (Pswal), and quality of life (QoL) in these patients during RT. Read More

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http://dx.doi.org/10.1002/hed.25684DOI Listing
February 2019

Outcomes of surgical treatment for hemangiomas.

Pediatr Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina.

Objective: To quantify complications and rates of adverse events associated with surgical excision of hemangiomas in children using a national surgical database.

Data Source: Pediatric American College of Surgeons (ACS) National Surgical Quality Improvement Program (ACS NSQIP -pediatric), years 2012-2016.

Methods: Subjects included children under 18 years with a postoperative diagnosis of International Classification of Diseases (ICD), 9th revision code: 228. Read More

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http://dx.doi.org/10.1111/pde.13751DOI Listing
February 2019

Body mass index, body shape, and risk of nasopharyngeal carcinoma: A population-based case-control study in Southern China.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China.

Whether the association between body size or shape and nasopharyngeal carcinoma (NPC) risk exists or varies by age-specific body size indicators is unclear. In a population-based case-control study conducted in Southern China between 2010 and 2014, self-reported height, weight, and body shape at age 20 and 10 years before interview were collected from 2448 histopathologically confirmed NPC cases and 2534 population-based controls. Body mass index (BMI) was categorized according to the World Health Organization guidelines for Asian populations: underweight (<18. Read More

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http://dx.doi.org/10.1002/cam4.2027DOI Listing
February 2019

DIAPH2 alterations increase cellular motility and may contribute to the metastatic potential of laryngeal squamous cell carcinoma.

Carcinogenesis 2019 Feb 21. Epub 2019 Feb 21.

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.

Low 5-year survival rate in laryngeal squamous cell carcinoma (LSCC) is to large extent attributable to high rate of recurrences and metastases. Despite the importance of the latter process, its complex genetic background remains not fully understood. Recently, we identified two metastasis related candidates genes, DIAPH2 and DIAPH3 to be frequently targeted by hemizygous/homozygous deletions, respectively, in LSCC cell lines. Read More

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http://dx.doi.org/10.1093/carcin/bgz035DOI Listing
February 2019

Successful Treatment of Sinusitis in Two Lung Transplant Recipients: Review of the Literature and Recommendations for Management.

Allergy Rhinol (Providence) 2019 Jan-Dec;10:2152656719827253. Epub 2019 Feb 5.

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Background: fungal infection is an emerging disease which is difficult to diagnose and treat. Patients undergoing lung transplant may be colonized prior to transplantation and are at risk for lethal allograft infection after transplantation.

Objectives: To identify and evaluate treatment options. Read More

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http://dx.doi.org/10.1177/2152656719827253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376547PMC
February 2019

Experience of thyroid surgery at tertiary referral centers in Jazan Hospitals, Saudi Arabia.

Interv Med Appl Sci 2018 Dec;10(4):198-201

Faculty of Medicine, Department of Otorhinolaryngology-Head and Neck Surgery, Prince Mohammed bin Nasser Hospital, Jazan, Saudi Arabia.

Background: Benign multinodular goiter (BMNG) is a common disease of the thyroid gland with palpable thyroid nodules that may be detected in 0.8%-1.5% of men and 5. Read More

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http://dx.doi.org/10.1556/1646.10.2018.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376351PMC
December 2018

Exercise-induced laryngeal obstruction in athletes treated with inspiratory muscle training.

BMJ Open Sport Exerc Med 2019 18;5(1):e000436. Epub 2019 Jan 18.

Department of Physiotherapy, Haukeland University Hospital, Bergen, Norway.

Background: Exercise-induced laryngeal obstruction (EILO) is common in athletes and presents with dyspnoea, chest tightness, inspiratory stridor and sometimes panic reactions. The evidence for conservative treatment is weak, but case reports suggest effects from inspiratory muscle training (IMT). We aimed to explore effects from IMT used in athletes with EILO. Read More

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http://dx.doi.org/10.1136/bmjsem-2018-000436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350751PMC
January 2019

Analysis of Structure and Dynamics in Three-Neuron Motifs.

Front Comput Neurosci 2019 7;13. Epub 2019 Feb 7.

Experimental Otolaryngology, Neuroscience Lab, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Recurrent neural networks can produce ongoing state-to-state transitions without any driving inputs, and the dynamical properties of these transitions are determined by the neuronal connection strengths. Due to non-linearity, it is not clear how strongly the system dynamics is affected by discrete local changes in the connection structure, such as the removal, addition, or sign-switching of individual connections. Moreover, there are no suitable metrics to quantify structural and dynamical differences between two given networks with arbitrarily indexed neurons. Read More

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http://dx.doi.org/10.3389/fncom.2019.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374328PMC
February 2019

CT Texture Analysis of Cervical Lymph Nodes on Contrast-Enhanced [F] FDG-PET/CT Images to Differentiate Nodal Metastases from Reactive Lymphadenopathy in HIV-Positive Patients with Head and Neck Squamous Cell Carcinoma.

AJNR Am J Neuroradiol 2019 Feb 21. Epub 2019 Feb 21.

From the Departments of Radiology (H.K., N.G., M.M.Q., M.N.C., B.L., S.K.M., M.T.T., K.T., O.S.)

Background And Purpose: Differentiating nodal metastases from reactive adenopathy in HIV-infected patients with [F] FDG-PET/CT can be challenging because lymph nodes in HIV-positive patients often show increased [F] FDG uptake. The purpose of this study was to assess CT textural analysis characteristics of HIV-positive and HIV-negative lymph nodes on [F] FDG-PET/CT to differentiate nodal metastases from disease-specific nodal reactivity.

Materials And Methods: Nine HIV-positive patients with head and neck squamous cell carcinoma (7 men, 2 women; 29-62 years of age; median age, 48 years) with 22 lymph nodes (≥1 cm) who underwent contrast-enhanced CT with [F] FDG-PET followed by pathologic evaluation of cervical lymph nodes were retrospectively reviewed. Read More

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http://dx.doi.org/10.3174/ajnr.A5974DOI Listing
February 2019

Etiology-Specific Mineralization Patterns in Patients with Labyrinthitis Ossificans.

AJNR Am J Neuroradiol 2019 Feb 21. Epub 2019 Feb 21.

From the Departments of Radiology (K.B., B.B., A.F., M.M.Q., K.T., O.S.)

Background And Purpose: Our aim was to identify whether specific patterns of ossification in labyrinthitis ossificans are associated with the known risk factors. Labyrinthitis ossificans has been described as sequela of prior temporal bone trauma, prior infection, and other disorders including sickle cell disease. Specific patterns of mineralization in the membranous labyrinth associated with these risk factors has not been previously described. Read More

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http://dx.doi.org/10.3174/ajnr.A5985DOI Listing
February 2019

Measurement Reliability of Laryngeal Resistance and Mean Flow Rate in Pediatric Subjects.

J Voice 2019 Feb 19. Epub 2019 Feb 19.

University of Wisconsin School of Medicine and Public Health, Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Madison, Wisconsin. Electronic address:

Objective: Mean flow rate (MFR) and laryngeal resistance (R) are sensitive to changes in glottal configuration and biomechanics. There is little reported on aerodynamic parameters in children. We conducted a pilot study to evaluate MFR and R measurement reliability in a pediatric population using labial and mechanical interruption methods. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.02.005DOI Listing
February 2019

Pharmacokinetics and tissue distribution of neurotrophin 3 after intracochlear delivery.

J Control Release 2019 Feb 18. Epub 2019 Feb 18.

Bionics Institute, Melbourne, Australia; University of Melbourne, Department of Medical Bionics, Melbourne, Australia; University of Melbourne, Department of Otolaryngology, Melbourne, Australia.

Neurotrophin therapy has potential to reverse some forms of hearing loss. However, cochlear pharmacokinetic studies are challenging due to small fluid volumes. Here a radioactive tracer was used to determine neurotrophin-3 retention, distribution and clearance after intracochlear administration. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.018DOI Listing
February 2019

Reversible External Auditory Canal Ligation (REACL): A Novel Surgical Technique to Induce Transient and Reversible Hearing Loss in Developing Rats.

J Neurosci Methods 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. Electronic address:

Background: Cases of sensory loss provide an excellent model to study the plastic nature of cortical sensory systems. Models of reversible sensory loss are particularly useful for establishing the onset and offset of various critical periods for cortical plasticity. However, there currently is an absence of adequate methods to produce reversible hearing loss in neonatal and developing rodents. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.02.011DOI Listing
February 2019

Obstructive Sleep Apnea and Cardiovascular Risk in Pediatrics.

Chest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

Obstructive sleep apnea (OSA) occurs in approximately 1% to 5% of children in the United States. Long-term cardiovascular risks associated with OSA in the adult population are well-documented. Although changes in blood pressure regulation occur in children with OSA, the pathways leading to chronic cardiovascular risks of OSA in children are less clear. Read More

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http://dx.doi.org/10.1016/j.chest.2019.02.011DOI Listing
February 2019

The role of chemotherapy in the treatment of stage II nasopharyngeal carcinoma: Retrospective analysis of the national cancer database.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine, University of Missouri, Kansas City, Missouri.

The standard of care treatment for locally advanced nasopharyngeal carcinoma (NPC) includes both chemotherapy and definitive radiation. However, there are limited data on the optimal management of stage II NPC. We performed a retrospective analysis of the National Cancer Database to analyze the treatment patterns and role of chemotherapy in patients with stage II NPC. Read More

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http://dx.doi.org/10.1002/cam4.2033DOI Listing
February 2019

An Unusual Case of Lacrimal Duct Obstruction in a Teenager.

JAMA Otolaryngol Head Neck Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1001/jamaoto.2018.4264DOI Listing
February 2019

Evaluation of a Preoperative Adverse Event Risk Index for Patients Undergoing Head and Neck Cancer Surgery.

JAMA Otolaryngol Head Neck Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

Importance: Patients 65 years or older are the most frequent users of operative resources and are also the most vulnerable to postoperative adverse events (AEs). Frailty indices are increasingly being used for preoperative risk stratification within head and neck cancer surgery, but most models lack a multifactorial basis and cannot be directly applied to clinical practice. A practical risk index is needed for clinicians to gauge risk factors preoperatively. Read More

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http://dx.doi.org/10.1001/jamaoto.2018.4513DOI Listing
February 2019

Association of Periosteal Sweeping vs Periosteal Preservation With Early Periorbital Sequelae Among Patients Undergoing External Perforating Osteotomy During Rhinoplasty.

JAMA Facial Plast Surg 2019 Feb 21. Epub 2019 Feb 21.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, California.

Importance: Periorbital sequelae are a significant source of early postoperative morbidity after rhinoplasty, particularly after an osteotomy is performed.

Objective: To compare postoperative periorbital sequelae after external perforating lateral osteotomy in rhinoplasty using a periosteal sweeping vs a periosteal preserving approach.

Design, Setting, And Participants: This prospective cohort study conducted at a tertiary referral center located in Mansoura, Egypt, included 28 patients who underwent external perforating lateral osteotomy in open rhinoplasty between January and May 2017. Read More

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http://dx.doi.org/10.1001/jamafacial.2018.1730DOI Listing
February 2019

Eosinophilic Esophagitis-A Primer for Otolaryngologists.

JAMA Otolaryngol Head Neck Surg 2019 Feb 21. Epub 2019 Feb 21.

Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Illinois College of Medicine at Peoria, Peoria.

Importance: Eosinophilic esophagitis (EoE) is a chronic, inflammatory condition of the esophagus. Prevalence of EoE is on the rise and, owing to its associated extragastrointestinal manifestations and comorbidities, otolaryngologists are increasingly encountering this condition in their practice.

Observations: Symptoms of EoE are vague and vary greatly based on patient's age. Read More

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http://dx.doi.org/10.1001/jamaoto.2018.4177DOI Listing
February 2019

JAMA Otolaryngology-Head & Neck Surgery.

Authors:

JAMA Otolaryngol Head Neck Surg 2019 Feb;145(2):104

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http://dx.doi.org/10.1001/jamaoto.2018.2735DOI Listing
February 2019

Comparison of the Financial Burden of Survivors of Head and Neck Cancer With Other Cancer Survivors.

JAMA Otolaryngol Head Neck Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Otolaryngology-Head and Neck Surgery, Saint Louis University, St Louis, Missouri.

Importance: Head and neck cancer (HNC) is more common among socioeconomically disenfranchised individuals, making financial burden particularly relevant.

Objective: To assess the financial burdens of HNC compared with other cancers.

Design, Setting, And Participants: In this retrospective review of nationally representative, publicly available survey, data from the Medical Expenditure Panel Survey were extracted from January 1, 1998, to December 31, 2015. Read More

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http://dx.doi.org/10.1001/jamaoto.2018.3982DOI Listing
February 2019

Head and Neck Cancer Compared With Other Cancers-Does the Great Equalizer Equalize Equally?

JAMA Otolaryngol Head Neck Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston.

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http://dx.doi.org/10.1001/jamaoto.2018.4072DOI Listing
February 2019

Width of Patulous Eustachian Tube: Comparison of Assessment by Sonotubometry and Tubo-tympano-aerography.

Otol Neurotol 2019 Feb 7. Epub 2019 Feb 7.

Sen-En Rifu Otologic Surgery Center, Miyagi-gun.

Objective: To assess the accuracy of tubo-tympano-aerodynamic-graphy (TTAG) in the estimation of morphological severity of patulous Eustachian tube (PET), and to compare the results with that of sonotubometry in clinical cases and in model experiments.

Study Design: Retrospective chart review and model experiment.

Setting: Tertiary referral center. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002141DOI Listing
February 2019

Association of Tympanostomy Tubes With Future Risk of Advanced Ear Surgery-A Population Study.

Otol Neurotol 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology, Kingston Health Sciences Centre.

Objective: To investigate future surgery for chronic ear disease in children who underwent tympanostomy tube (TT) placement, compared with non-surgically treated patients and healthy controls.

Study Design: Retrospective population-based cohort study.

Setting: All hospitals in the Canadian province of Ontario. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002145DOI Listing
February 2019

The role of frozen section biopsy for parotid gland tumour with benign fine-needle aspiration cytology.

J Laryngol Otol 2019 Feb 21:1-3. Epub 2019 Feb 21.

Department of Otolaryngology,School of Medicine,Fukushima Medical University,Japan.

Objectives: This study focused on parotid gland tumours diagnosed as benign by fine-needle aspiration cytology and investigated the necessity of frozen section biopsy.

Methods: There were 104 cases of parotid gland tumour where fine-needle aspiration cytology was benign and frozen section biopsy was subsequently performed, between April 2006 and June 2016. In this retrospective study, the results of frozen section biopsy were analysed and compared with the final histological diagnosis. Read More

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http://dx.doi.org/10.1017/S002221511900029XDOI Listing
February 2019

Clinical outcomes of end-flexible-rigidscopic transoral surgery (E-TOS) in patients with T1-selected T3 pharyngeal and supraglottic cancers.

Acta Otolaryngol 2019 Feb 21:1-8. Epub 2019 Feb 21.

a Otolaryngology-Head & Neck Surgery , Osaka Red Cross Hospital , Osaka , Japan.

Background: Endoscopic laryngo-pharyngeal surgery (ELPS), which is a transoral minimally invasive surgery using a gastrointestinal endoscope and a curved laryngopharyngeal retractor, is effective to treat primary lesions of superficial laryngopharyngeal cancers. To extend concepts of ELPS to invasive laryngopharyngeal cancers, we developed end-flexible-rigidscopic transoral surgery (E-TOS) from ELPS by changing a gastrointestinal endoscope to a flexible-tip rigid endoscope.

Aims/objectives: To retrospectively evaluate oncological outcomes and laryngopharyngeal functional preservation of E-TOS in patients with T1-selected T3 laryngopharyngeal cancers. Read More

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http://dx.doi.org/10.1080/00016489.2018.1532106DOI Listing
February 2019

Orbital Complications of Rhinosinusitis in the Adult Population: Analysis of Cases Presenting to a Tertiary Medical Center Over a 13-Year Period.

Ann Otol Rhinol Laryngol 2019 Feb 21:3489419832624. Epub 2019 Feb 21.

1 Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah-Tikva.

Background:: Orbital complications of rhinosinusitis in adults are scarcely discussed in the literature.

Objective:: To review our experience with the management of orbital complications of rhinosinusitis in the adult patient population and identify key factors in the characteristics and management of these patients.

Design:: Retrospective case series during the years 2004 to 2016 in a tertiary referral center including all patients with rhinosinusitis and orbital complications. Read More

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http://dx.doi.org/10.1177/0003489419832624DOI Listing
February 2019

Alopecia and techniques in hair restoration: an overview for the cosmetic surgeon.

Oral Maxillofac Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Orthopedics and Plastic Surgery, Wright State University, Dayton, OH, USA.

Purpose: Alopecia is a debilitating disorder affecting millions of individuals worldwide. Although challenging to treat, advances in hair restoration technologies have led to multiple viable options with excellent clinical results. This paper seeks to provide an overview of hair loss and the currently utilized techniques in hair transplantation in order to serve as a reference source for the facial plastic surgeon. Read More

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http://dx.doi.org/10.1007/s10006-019-00750-9DOI Listing
February 2019

Budesonide nasal irrigation improved Lund-Kennedy endoscopic score of chronic rhinosinusitis patients after endoscopic sinus surgery.

Eur Arch Otorhinolaryngol 2019 Feb 20. Epub 2019 Feb 20.

Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Guangzhou, 510630, Guangdong, People's Republic of China.

Purpose: Budesonide improves the prognosis of chronic rhinosinusitis (CRS). However, few reports have examined whether its use for nasal irrigation, compared to normal saline, improves the prognosis of patients after endoscopic sinus surgery (ESS). We compared the effects of nasal irrigation with budesonide and normal saline in CRS patients after ESS. Read More

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http://dx.doi.org/10.1007/s00405-019-05327-6DOI Listing
February 2019

Recognizing taste: coding patterns along the neural axis in mammals.

Chem Senses 2019 Feb 20. Epub 2019 Feb 20.

Dept. of Physiology & Biophysics, Dept. of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.

The gustatory system encodes information about chemical identity, nutritional value, and concentration of sensory stimuli before transmitting the signal from taste buds to central neurons that process and transform the signal. Deciphering the coding logic for taste quality requires examining responses at each level along the neural axis - from peripheral sensory organs to gustatory cortex. From the earliest single fiber recordings, it was clear that some afferent neurons respond uniquely, others to stimuli of multiple qualities. Read More

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http://dx.doi.org/10.1093/chemse/bjz013DOI Listing
February 2019

The Expression of SOCS and NF-ϰB p65 in Hypopharyngeal Carcinoma.

Iran J Public Health 2018 Dec;47(12):1874-1882

Dept. of Nutriology, The Second Hospital of Shandong University, Jinan, Shandong, China.

Background: Hypopharyngeal carcinoma is one of the most common types of head and neck tumors. Suppressers of cytokine signalling (SOCS) family members are key regulators of cytokine homeostasis, they play important roles in the process of cell proliferation, differentiation, maturation and apoptosis, and participate in the occurrence and development of tumor. The abnormal activation of NF-ϰB is an important feature of the tumor. Read More

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December 2018

Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use.

Sci Rep 2019 Feb 20;9(1):2410. Epub 2019 Feb 20.

Institute of Biology and Molecular Genetics (IBGM), University of Valladolid-CSIC, Valladolid, Spain.

Spread of antimicrobial resistance and shortage of novel antibiotics have led to an urgent need for new antibacterials. Although aminoglycoside antibiotics (AGs) are very potent anti-infectives, their use is largely restricted due to serious side-effects, mainly nephrotoxicity and ototoxicity. We evaluated the ototoxicity of various AGs selected from a larger set of AGs on the basis of their strong antibacterial activities against multidrug-resistant clinical isolates of the ESKAPE panel: gentamicin, gentamicin C1a, apramycin, paromomycin and neomycin. Read More

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http://dx.doi.org/10.1038/s41598-019-38634-3DOI Listing
February 2019

[THE EXAMINATION OF IGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS RESPONSES TO FLOUR EXTRACTS IN A BAKER'S RHINITIS PATIENT].

Arerugi 2019 ;68(1):35-42

Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Background: Baker's rhinitis is a kind of occupational allergic rhinitis mainly caused by intranasal exposure to wheat and/or rye flour in bakery workers. Continuous exposure to flour may induce the onset of asthma in these patients.

Method: We experienced a case of 34-year-old male with baker's rhinitis without asthma, and investigated responses of IgE and peripheral blood mononuclear cells (PBMCs) to flour extracts used in the bakery in practice. Read More

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http://dx.doi.org/10.15036/arerugi.68.35DOI Listing
January 2019

HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.

EMBO Rep 2019 Feb 20. Epub 2019 Feb 20.

Department of Integrative Biology and Pharmacology, McGovern Medical School, the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA

By serving as intermediaries between cellular metabolism and the bioenergetic demands of proliferation, endolysosomes allow cancer cells to thrive under normally detrimental conditions. Here, we show that an endolysosomal TRP channel, TRPML1, is necessary for the proliferation of cancer cells that bear activating mutations in Expression of , which encodes TRPML1, is significantly elevated in -positive tumors and inversely correlated with patient prognosis. Concordantly, knockdown or TRPML1 inhibition selectively reduces the proliferation of cancer cells that express oncogenic, but not wild-type, Mechanistically, TRPML1 maintains oncogenic HRAS in signaling-competent nanoclusters at the plasma membrane by mediating cholesterol de-esterification and transport. Read More

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http://dx.doi.org/10.15252/embr.201846685DOI Listing
February 2019

Histopathological and hematological changes in recurrent nasal polyposis.

Int Forum Allergy Rhinol 2019 Feb 20. Epub 2019 Feb 20.

Otolaryngology Section, Department of Neuroscience (DNS), Padova University, Padova, Italy.

Background: There is a dearth of information regarding the histological and hematological differences between primary and recurrent chronic rhinosinusitis with nasal polyps (CRSwNP). The present study analyzed the histological changes in recurrent CRSwNP in terms of eosinophilic infiltrate, subepithelial edema, goblet cell hyperplasia, and basement membrane thickness. Blood levels of eosinophils and basophils were also measured prior to surgery on both primary and recurrent disease. Read More

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http://dx.doi.org/10.1002/alr.22314DOI Listing
February 2019

Hemodynamic and pharmacokinetic analysis of oxymetazoline use during nasal surgery in children.

Laryngoscope 2019 Feb 20. Epub 2019 Feb 20.

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

Objectives/hypothesis: Oxymetazoline is an α-adrenergic agonist that is commonly used as a topical hemostatic agent in the operating room during ear, nose, and throat surgery. There are limited data on oxymetazoline pharmacokinetics in children who undergo general anesthesia. We assessed the hemodynamic effects and systemic absorption of topically applied oxymetazoline in children undergoing various nasal procedures. Read More

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http://dx.doi.org/10.1002/lary.27760DOI Listing
February 2019
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A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy.

Laryngoscope 2019 Feb 20. Epub 2019 Feb 20.

Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Taiwan.

Objective: There is no useful tool to clinically predict the occurrence of osteoradionecrosis (ORN) of the mandible quantitatively. The aim was to investigate the risk factors, including different modalities of radiotherapy, for developing mandibular ORN in patients undergoing marginal mandibulectomy and postoperative radiotherapy.

Methods: Between January 2006 and December 2012, 167 subjects who underwent marginal mandibulectomy and postoperative radiotherapy with different modalities were enrolled. Read More

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http://dx.doi.org/10.1002/lary.27870DOI Listing
February 2019

Epidemiology and resource utilization of ludwig angina ED visits in the United States 2006-2014.

Laryngoscope 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, Division of Otolaryngology/Head & Neck Surgery, Howard University College of Medicine, Washington, District of Columbia, U.S.A.

Objectives: Ludwig angina is a potentially lethal submandibular space infection. We aim to describe the epidemiological characteristics of Ludwig angina patients presenting to the emergency department (ED) and to examine outcomes and resource utilization to determine their burden on ED and hospitals.

Methods: Using the Nationwide Emergency Department Sample database, a nationally representative all-payer database, we retrospectively reviewed all ED visits between 2006 and 2014 for patients admitted with a primary diagnosis of Ludwig angina (International Classification of Diseases, Ninth Revision, 528. Read More

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http://dx.doi.org/10.1002/lary.27734DOI Listing
February 2019

Transoral Robotic Thyroidectomy Versus Conventional Open Thyroidectomy: Comparative Analysis of Surgical Outcomes in Thyroid Malignancies.

J Laparoendosc Adv Surg Tech A 2019 Feb 20. Epub 2019 Feb 20.

5 Division for Endocrine and Minimal Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G.Barresi," University Hospital "G.Martino," University of Messina, Messina, Italy.

Background: Various approaches for thyroid surgery became possible with the use of robotic systems. Transoral robotic thyroidectomy (TORT) is one of the newest approaches and draws attention because of its cosmetic excellence. In this study, we compared the surgical outcomes of TORT and conventional open thyroidectomy (OT). Read More

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http://dx.doi.org/10.1089/lap.2018.0587DOI Listing
February 2019