114,870 results match your criteria Journal of Laryngology & Otology[Journal]


Preoperative and histological predictors of recurrence and survival in atypical meningioma after initial gross total resection.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA 10029. Electronic address:

Objective: Atypical (WHO grade II) meningiomas (AM) are associated with a substantial risk for recurrence even following a complete, gross total resection (GTR). The present study aimed to evaluate clinical and AM tumor histopathological features that may predict risk of recurrence and survival within this patient population.

Methods: 72 consecutive patients and corresponding tumor specimens who received a primary GTR for an AM from 2007-2016 at a single institution were reviewed. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.069DOI Listing

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

Cell Rep 2019 Apr;27(3):860-871.e8

Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Inflammation Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

A truncating mutation in the mouse Srrm4 gene, which encodes a neuronal splicing factor, causes alternative splicing defects selectively in the ear. The mechanism by which splicing is preserved in the brain of these mice is not known. Here, we show that SRRM3 limits the Srrm4 mutation-associated defects to the ear and that, in cortical neurons, overlapping SRRM3-SRRM4 activity regulates the development of interneuronal inhibition. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.072DOI Listing

A review on screening tests for vestibular disorders.

Authors:
Helen S Cohen

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Bobby R Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, United States.

Although many studies have reported on tests of the vestibular system a valid and reliable, evidence-based screening battery for easy clinical use remains elusive. Many screening tests attempt to assess the vestibulo-ocular reflex. Therefore, head shaking, the Dix-Hallpike maneuver, the supine roll test and head impulse tests are discussed. Read More

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http://dx.doi.org/10.1152/jn.00819.2018DOI Listing

Comparison of postoperative voice outcomes after postauricular facelift robotic hemithyroidectomy and conventional transcervical hemithyroidectomy.

Head Neck 2019 Apr 17. Epub 2019 Apr 17.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Background: The purpose of this study was to determine whether postauricular robotic and conventional hemithyroidectomy result in significantly different voice outcomes.

Methods: We prospectively compared the voice handicap index (VHI)-10 and acoustic parameters of a postauricular facelift robotic group and a conventional group preoperatively, 1 week, 1 month, and 6 months after surgery.

Results: Forty-two patients in the postauricular group and 68 patients in the conventional group completed the VHI-10 questionnaire and acoustic analysis. Read More

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http://dx.doi.org/10.1002/hed.25777DOI Listing

Optimum Coupling of an Active Middle Ear Actuator: Effect of Loading Forces on Actuator Output and Conductive Losses.

Otol Neurotol 2019 Apr 10. Epub 2019 Apr 10.

Department of Otolaryngology and Institute of Audioneurotechnology (VIANNA), Hannover Medical School, Hannover, Germany.

Introduction: The desired outcome of the implantation of active middle ear implants is maximum coupling efficiency and a minimum of conductive loss. It has not been investigated yet, which loading forces are applied during the process of coupling, which forces lead to an optimum actuator performance and which forces occur when manufacturer guidelines for coupling are followed.

Methods: Actuator output was measured by laser Doppler vibrometry of stapes motion while the actuator was advanced in 20 μm steps against the incus body while monitoring static contact force. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002253DOI Listing

Primary Petrous Apex Epidermoids With Skull Base Erosion.

Otol Neurotol 2019 Apr 10. Epub 2019 Apr 10.

Division of Otolaryngology - Head and Neck Surgery, University of Utah, Salt Lake City, Utah.

Objective: To describe the clinical course and treatment outcomes for patients with petrous apex epidermoid with skull base erosion.

Study Design: Retrospective case series.

Setting: Tertiary-care academic center. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002199DOI Listing
April 2019
1 Read

Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders.

Otol Neurotol 2019 Apr 10. Epub 2019 Apr 10.

Department of Otolaryngology Head and Neck Surgery, Hannover Medical School, Hannover.

Objective: To provide an overview of biotechnology and pharmaceutical companies active in the field of inner ear and central hearing disorders and their therapeutic approaches.

Methods: Scientific and grey literature was searched using broad search terms to identify companies and their hearing-related therapeutic approaches. For each approach its lead indication, product, therapeutic modality, target, mechanism of action and current phase of clinical development was collated. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002194DOI Listing

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing

Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss.

Clin Exp Otorhinolaryngol 2019 Mar 27. Epub 2019 Mar 27.

Department of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing City, China.

Objectives: To investigate glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) gene expression and protein levels in peripheral blood mononuclear cells (PBMCs) of patients with severe or profound sudden sensorineural hearing loss (SSNHL) and to explore the roles of GRs and HDAC2 in glucocorticoid (GC) insensitivity.

Methods: Fifty-five severe or profound SSNHL patients were enrolled in the study. According to hearing improvement after GC treatment, patients were assigned into two groups: GC-sensitive and GC-resistant. Read More

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http://dx.doi.org/10.21053/ceo.2018.01298DOI Listing

Does drug-induced sleep endoscopy affect surgical outcome? A multicenter study of 326 obstructive sleep apnea patients.

Laryngoscope 2019 Apr 17. Epub 2019 Apr 17.

Otolaryngology Department, Western University, London, Ontario, Canada.

Objectives/hypothesis: Our objective was to determine whether drug-induced sleep apnea (DISE) affects the successfulness of the surgical outcome.

Study Design: Prospective, seven-country, nonrandomized trial.

Methods: There were 326 consecutive obstructive sleep apnea (OSA) patients who had nose, palate, and/or tongue surgery included in the study. Read More

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http://dx.doi.org/10.1002/lary.27987DOI Listing

Long noncoding RNA PTPRG-AS1 acts as a microRNA-194-3p sponge to regulate radiosensitivity and metastasis of nasopharyngeal carcinoma cells via PRC1.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Protein regulator of cytokinesis 1 (PRC1) has been reported in correlation with various malignancies. Functionality of PRC1 in nasopharyngeal carcinoma (NPC) was investigated, in perspective of long noncoding RNA (lncRNA) regulatory circuitry. Aberrant expressed messenger RNA and lncRNA were screened out from the Gene Expression Omnibus microarray database. Read More

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http://dx.doi.org/10.1002/jcp.28547DOI Listing

A qualitative study investigating the meaning of participation to improve the measurement of this construct.

Qual Life Res 2019 Apr 16. Epub 2019 Apr 16.

Coronel Institute of Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Purpose: The purpose of this study was to improve the measurement of participation. Research questions were as follows: (1) What constitutes participation according to adults? (2) Do they mention participation subdomains that are not covered in the Patient-Reported Outcomes Measurement Information System (PROMIS) item bank "Ability to Participate in Social Roles and Activities"?

Methods: Semi-structured interviews were conducted with 46 adults from the general population. Interviews were thematically analysed using the International Classification of Functioning, Disability and Health (ICF) as conceptual framework. Read More

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http://dx.doi.org/10.1007/s11136-019-02179-9DOI Listing

A preclinical evaluation of thiostrepton, a natural antibiotic, in nasopharyngeal carcinoma.

Invest New Drugs 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No.201, Sec.2, Shipai Road, Taipei, 112, Taiwan.

Background Thiostrepton, a natural antibiotic, has recently been shown to be a potential anticancer drug for certain cancers, but its study in nasopharyngeal carcinoma (NPC) is still limited. The aims of this study were to investigate the anticancer effect of thiostrepton on NPC cells and to explore its underlying mechanism. Methods The effects of thiostrepton on the proliferation, migration, and invasion of NPC cells were investigated by a WST-1 assay, wound healing assay, and cell invasion assay, respectively. Read More

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http://link.springer.com/10.1007/s10637-019-00779-3
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http://dx.doi.org/10.1007/s10637-019-00779-3DOI Listing
April 2019
1 Read

Health-related and cancer-related Internet use by patients treated with total laryngectomy.

Support Care Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioral and Movement Sciences, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: To investigate among patients treated with a total laryngectomy (TL) (1) Internet-use and Internet use to search for information on health and cancer (content); (2) which patients are most likely to use the Internet in general, for health-related and cancer-related purposes; (3) which other types of eHealth (community, communication, care) are used; and (4) preferences towards future use.

Methods: Patient members of the Dutch TL patient society were asked to complete a questionnaire on Internet use, health-related and cancer-related Internet use, types of eHealth, preferences towards future use, socio-demographics, clinical factors, and quality of life (QOL). Factors associated with Internet use and health-related and cancer-related Internet use were investigated using stepwise logistic regression analysis. Read More

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http://link.springer.com/10.1007/s00520-019-04757-6
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http://dx.doi.org/10.1007/s00520-019-04757-6DOI Listing
April 2019
1 Read

Pharmacological intervention in the field of ototoxicity.

Authors:
G Laurell

HNO 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Uppsala University, Akademiska sjukhuset ing 78-79, 75185, Uppsala, Sweden.

Modern research on ototoxicity goes back to the 1940s, when streptomycin was introduced into clinical practice. Today, aminoglycoside antibiotics and platinum-based chemotherapy, mainly cisplatin, are the most important drugs that damage the inner ear and cause hearing loss. The mode of drug administration as well as drug characteristics influence the likelihood that adequate monitoring of drug pharmacokinetics can be performed. Read More

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http://dx.doi.org/10.1007/s00106-019-0663-1DOI Listing

Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study).

Clin Exp Otorhinolaryngol 2019 Apr 18. Epub 2019 Apr 18.

Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.

Objectives: There is a great deal of interest in the possibility that environmental factors may influence the risk of developing allergic rhinitis (AR) in early life. We investigated the simultaneous effects of mode of delivery and duration of breastfeeding on the development of AR in children.

Methods: Data from 1,374 children participating in the Allergic Rhinitis Cohort Study for kids (ARCO-kids study) was analyzed. Read More

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http://dx.doi.org/10.21053/ceo.2018.01781DOI Listing
April 2019
1 Read

Putative biomarkers of malignant transformation of sinonasal inverted papilloma into squamous cell carcinoma.

J Int Med Res 2019 Apr 16:300060519838385. Epub 2019 Apr 16.

1 Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: To compare genome-wide DNA methylation between samples of sinonasal inverted papilloma (SNIP) and squamous cell carcinoma (SCC) samples in order to identify aberrantly methylated genes that might be involved in malignant transformation.

Methods: Tissue samples were collected from patients. DNA methylation in C-phosphate-G islands and gene promoters was analysed using a DNA methylation microarray kit. Read More

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http://dx.doi.org/10.1177/0300060519838385DOI Listing

Castleman Disease Presenting as a Supraclavicular Neck Mass in a Child.

Ear Nose Throat J 2019 Jan 31:145561318824475. Epub 2019 Jan 31.

2 Department of Pediatric Otolaryngology, St Christopher's Hospital for Children, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/0145561318824475DOI Listing
January 2019
1 Read

Sensitivity of Fine-Needle Aspiration and Imaging Modalities in the Diagnosis of Low-Grade Mucoepidermoid Carcinoma of the Parotid Gland.

Ann Otol Rhinol Laryngol 2019 Apr 16:3489419842582. Epub 2019 Apr 16.

1 Department of Otolaryngology-Head and Neck Surgery, BS, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: To determine the diagnostic accuracy of fine-needle aspiration (FNA) and imaging modalities for low-grade mucoepidermoid carcinoma (MEC) of the parotid gland.

Methods: Retrospective chart review of patients diagnosed with low-grade MEC of the parotid gland following surgical excision between January 2010 and June 2018. Imaging from patients with MEC were randomly mixed with imaging from patients with benign pathology and reviewed in a blinded fashion. Read More

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http://dx.doi.org/10.1177/0003489419842582DOI Listing

Early Otorrhea Rates: A Randomized Trial of Ciprofloxacin versus Saline Drops after Tympanostomy Tubes.

Ann Otol Rhinol Laryngol 2019 Apr 16:3489419843550. Epub 2019 Apr 16.

1 Cleveland Clinic Otolaryngology, Cleveland, Ohio, USA.

Objective: The objectives of this study are to evaluate incidence, duration, and quality of life (QOL) impact of early tympanostomy tube otorrhea and tube patency when comparing topical ciprofloxacin versus normal saline use in the perioperative period.

Methods: Overall, 200 patients undergoing tube placement between November 19, 2015, and September 12, 2016, were randomized to intraoperative plus 5 days of either topical ciprofloxacin or normal saline. Parents or caregivers reported the incidence, duration, and QOL impact of early otorrhea via 4 weekly surveys. Read More

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http://dx.doi.org/10.1177/0003489419843550DOI Listing

[Application of the real-time fluorescence PCR melting curve method in gene screening of non-syndromic hearing loss].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):286-291

Department of Otorhinolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, China; Province Key Laboratory of Otorhinolaryngology Critical Diseases, Changsha 410008, China.

To detect 20 common deafness gene mutations in non-syndromic hearing loss patients in China using the melting curve method, and analyze and summarize the mutation data to explore the clinical value of this method. The real-time fluorescence PCR melting curve method was used to detect 20 common mutations of four deafness genes( and ) in 492 patients with non-syndromic hearing loss recruited between March 2014 and September 2016 from the Otolaryngology Department of Xiangya Hospital, Central South University(283 males and 209 females, the age ranged from 1 to 48 years old). The Sanger sequencing method was used to compare the sensitivity, specificity, positive predictive value, negative predictive value, and total coincidence rate of the deafness mutation detected by the real-time fluorescence PCR melting curve method. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.009DOI Listing

[The effect of NK-1R-siRNA on expression of inflammatory factors in allergic rhinitis].

Authors:
H Wang J Wu R X Zhang

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):280-285

Department of Otolaryngology, Huadong Hospital, Fudan University, Shanghai 200040, China.

To explore the effect of neurokinin-1 receptor small interfering RNA (NK-1R-siRNA) on the expression of inflammation factors in allergic rhinitis (AR). Twenty-four male SD rats were divided into three groups randomly (by random number table methord): NK-1R-siRNA group, negative control siRNA (NC-siRNA) group and saline group, with 8 rats in each group. SD rats were sensitized and challenged with ovalbumin (OVA) to induce AR. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.008DOI Listing
April 2019
1 Read

Preoperative ultrasound for the diagnosis of thyroglossal duct cysts: A validation study.

Int J Pediatr Otorhinolaryngol 2019 Mar 29;122:89-92. Epub 2019 Mar 29.

Head and Neck Institute, Department of Otolaryngology-Head and Neck Surgery, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Objectives: To evaluate the use of ultrasound to distinguish between thyroglossal duct cysts (TGDC) and dermoid cysts (DC) for surgical planning. To validate the SIST (septae + irregular wall + solid components = TGDC) scoring system proposed by Oyewumi et al. [1]. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193015
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http://dx.doi.org/10.1016/j.ijporl.2019.03.029DOI Listing
March 2019
1 Read

Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis.

Toxicol Lett 2019 Apr 13. Epub 2019 Apr 13.

Department of Otolaryngology Head & Neck Surgery, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, China. Electronic address:

Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but also peripheral nerves, including nerves associated with the auditory system. Our initial research on cochlear organotypic cultures in vitro showed that N-acetylcysteine (NAC) clearly decreases Mn-induced losses in hair cells (HCs), auditory nerve fibers (ANFs) and spiral ganglion neurons (SGNs) in a concentration-dependent manner. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.04.016DOI Listing

Casting.

JAMA 2019 Apr;321(15):1455-1456

Department of Otolaryngology, Massachusetts Eye and Ear, Boston.

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http://dx.doi.org/10.1001/jama.2019.3954DOI Listing

The Feasibility of a Prototype Thyroidoscope for Gasless Transoral Endoscopic Thyroidectomy: A Preclinical Cadaver Study.

J Laparoendosc Adv Surg Tech A 2019 Apr 16. Epub 2019 Apr 16.

2 Department of Otorhinolaryngology, Head and Neck Surgery, Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea.

Objective: This study aimed to evaluate the feasibility of the gasless transoral endoscopic thyroidectomy vestibular approach (TOETVA) using the Thyroidoscope, developed to maintain the surgical working space without CO insufflation.

Materials And Methods: To prevent a potentially fatal CO-related complication, we developed a retractable device, named the Thyroidoscope, which could maintain the surgical working space without CO insufflation. We conducted a preclinical cadaver study to evaluate its use in gasless TOETVA. Read More

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http://dx.doi.org/10.1089/lap.2019.0107DOI Listing

A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats.

Acta Otolaryngol 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Department of Otolaryngology , Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.

Background: Unilateral labyrinthectomy (UL) causes the disappearance of ipsilateral medial vestibular nuclear (ipsi-MVe) activity and induces spontaneous nystagmus (SN), which disappears during the initial process of vestibular compensation (VC). Ipsi-MVe-activity restores in the late process of VC.

Objective: We evaluated the late process of VC after UL in rats and examined the effects of thioperamide (H3 antagonist) on VC. Read More

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http://dx.doi.org/10.1080/00016489.2019.1599140DOI Listing

Noise and Room Acoustic Conditions in a Tertiary Referral Hospital, Seoul National University Hospital.

J Audiol Otol 2019 Apr 10;23(2):76-82. Epub 2019 Apr 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.

Background And Objectives: Noise levels and room acoustic parameters at a tertiary referral hospital, Seoul National University Hospital (SNUH) in Korea, are investigated.

Materials And Methods: Through a questionnaire, acoustically problematic rooms are identified. Noise levels in emergency rooms (ERs) and intensive care units (ICUs) are measured over about three days. Read More

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http://dx.doi.org/10.7874/jao.2018.00269DOI Listing

Integrated analysis of a competing endogenous RNA network reveals key long noncoding RNAs as potential prognostic biomarkers for hepatocellular carcinoma.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Research Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China.

Growing evidence has revealed that long noncoding RNAs (lncRNAs) have an important impact on tumorigenesis and tumor progression via a mechanism involving competing endogenous RNAs (ceRNAs). However, their use in predicting the survival of a patient with hepatocellular carcinoma (HCC) remains unclear. The aim of this study was to develop a novel lncRNA expression-based risk score system to accurately predict the survival of patients with HCC. Read More

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http://dx.doi.org/10.1002/jcb.28655DOI Listing

Outcomes of large vestibular schwannomas following subtotal resection: early post-operative volume regression and facial nerve function.

J Neurooncol 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurologic Surgery, Mayo Clinic Florida, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA.

Introduction: Subtotal resection (STR) of vestibular schwannoma (VS) tumors remains controversial and little is known regarding post-operative volume changes.

Methods: Authors retrospective reviewed the medical records from January 1st 2002 to January 1st 2018, for all patients who had undergone primary STR of large VS at a single tertiary academic institution.

Results: Our series consists of 34 patients with a mean age of 53. Read More

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http://dx.doi.org/10.1007/s11060-019-03157-4DOI Listing

The role of invariant T cells in inflammation of the skin and airways.

Semin Immunopathol 2019 Apr 15. Epub 2019 Apr 15.

Centre for Cancer Biology, The University of South Australia and SA Pathology, North Terrace, Adelaide, SA, 5000, Australia.

Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells express T cell receptors of very limited diversity. iNKT and MAIT cells recognise antigens presented by the MHC class 1-like monomorphic molecules CD1d and MR1, respectively. Read More

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http://link.springer.com/10.1007/s00281-019-00740-9
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http://dx.doi.org/10.1007/s00281-019-00740-9DOI Listing
April 2019
1 Read

Evaluation of Bilateral Vestibular Dysfunction in Iranian Adults and Elderlies by Electronystagmography and Video Head Impulse Test.

Iran J Otorhinolaryngol 2019 Mar;31(103):103-107

Markazi Vestibular Assessment and Rehabilitation Center, Mashhad, Iran.

Introduction: Vestibular abnormalities are common problems in the whole world, which can lead to bilateral vestibular dysfunction (BVD). That results in symptoms, such as vertigo, unsteadiness, falling, oscillopsia, and lower quality of life. The Objective of this study was to determine BVD in adults and elderlies with vertigo and unsteadiness. Read More

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Effect of Cold Diet and Diet at Room Temperature on Post-Tonsillectomy Pain in Children.

Iran J Otorhinolaryngol 2019 Mar;31(103):81-86

Department of Otolaryngology- Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Introduction: The present study aimed to compare the effect of cold diet and diet at room temperature on post-tonsillectomy pain in children.

Materials And Methods: In the present study a total of 120 children within the age range of 4-12 years who underwent tonsillectomy were randomly assigned to two groups, namely group C with a cold-served diet and group room temperaturewith a room-temperature-served diet postoperatively. Each patient's post-operative pain was evaluated using the Face, Legs, Activity, Cry, Consolability (FLACC) scale prior to oral diet initiation after the operation, before thesecond acetaminophen dose, before the next day breakfast, and before discharge. Read More

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Gene expression profile in mouse bacterial chronic rhinosinusitis.

Exp Ther Med 2019 May 8;17(5):3451-3458. Epub 2019 Mar 8.

Department of Otolaryngology, Shanghai General Hospital, Shanghai Jiaotong University, Hongkou, Shanghai 200080, P.R. China.

Persistent infection in the paranasal sinuses impairs sinus drainage and leads to bacterial chronic rhinosinusitis. Greater knowledge of the key molecules in the pathology will help to clarify the pathogenesis. Study of the gene expression profile and analysis of the associated pathway is important to identify key molecules. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7366
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http://dx.doi.org/10.3892/etm.2019.7366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447814PMC
May 2019
1 Read

Effect of transformer noise on the neurophysiology of SD rats.

Exp Ther Med 2019 May 7;17(5):3383-3390. Epub 2019 Mar 7.

Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Transformer noise is a type of environmental sound that causes discomfort to individuals. The aim of the present study was to determine the effect of relatively long-term periods of transformer noise on the behavior and neurophysiology of SD rats. A total of 90 healthy SD rats with normal hearing were randomly divided into two experimental groups (65 and 60 dB group) and a control group. Read More

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http://dx.doi.org/10.3892/etm.2019.7360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447807PMC

Longitudinal Case Study of Transgender Voice Changes Under Testosterone Hormone Therapy.

J Voice 2019 Apr 13. Epub 2019 Apr 13.

Graduate Program for Neuroscience, Boston University, Boston, Massachusetts; Department of Speech, Language, and Hearing Sciences, Boston University, Boston, Massachusetts; Department of Biomedical Engineering, Boston University, Boston, Massachusetts; Department of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts.

The purpose of this study was to comprehensively evaluate voice and speech changes in one healthy 30-year-old transgender male undergoing testosterone therapy for transition. Testing occurred at three timepoints before cross-sex hormone therapy and every 2 weeks thereafter for 1 year. Data collected included measures of acoustics, aerodynamics, and laryngeal structure and function via flexible laryngoscopy. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.03.006DOI Listing

Air Injection and Transillumination in Phonosurgery: A Novel Technique.

J Voice 2019 Apr 12. Epub 2019 Apr 12.

Istanbul Training and Research Hospital, Otolaryngology Head and Neck Surgery Department Istanbul, Turkey.

Objectives/hypothesis: The goal of this study was to introduce two novel techniques in phonomicrosurgery, air injection (AIR), and transillumination (TI), to improve the diagnosis and surgical excision of pathological tissue in vocal folds during suspension laryngoscopy while preserving the healthy tissue as much as possible.

Study Design: Prospective clinical case series.

Methods: Thirty-four patients with benign vocal cord lesions who underwent phonomicrosurgery between January 2016 and May 2017 were evaluated. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.03.009DOI Listing

Predictors of Obstetric Fistula Repair Outcomes in Lubango, Angola.

J Obstet Gynaecol Can 2019 Apr 12. Epub 2019 Apr 12.

Program in Global Surgery and Social Change, Harvard Medical School, Boston, MA; Center for Surgery and Public Health,(,) Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Objective: Obstetric fistulas have a significant physical and social impact on many women in Angola. The majority of the population of this sub-Saharan African nation does not have access to high-quality obstetric care, and this is associated with a risk of prolonged labour and formation of obstetric fistulas. Fistulas are challenging to correct surgically and may require repeated operations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163193008
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http://dx.doi.org/10.1016/j.jogc.2019.01.025DOI Listing
April 2019
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Intracapsular hemorrhage rates in non-fixated nylon sheet orbital implants for orbital fracture management.

Am J Otolaryngol 2019 Apr 9. Epub 2019 Apr 9.

Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA; Department of Ophthalmology, Indiana University, Indianapolis, IN, USA; Oculofacial Plastic and Orbital Surgery, Indianapolis, IN, USA; St. Vincent Hospital, Indianapolis, IN, USA. Electronic address:

Purpose: To examine the incidence of intracapsular hemorrhage in orbital fracture repair with non-fixated nylon sheet implants.

Methods: A retrospective chart review of 227 patients presenting from January 2013 to December 2016 for orbital fracture repair with nylon sheet implants.

Results: Of the 331 orbital fractures repaired over 4 years, a total of 227 met inclusion criteria. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.04.008DOI Listing

Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: A clinical trial.

Biomed J 2019 Feb 20;42(1):46-52. Epub 2019 Mar 20.

Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Otolaryngology, Chang Gung Memorial Hospital and Xiamen Medical Center, Fujian, China. Electronic address:

Background: Zinc plays a vital antioxidant role in human metabolism. Recent studies have demonstrated a correlation between noise-induced hearing loss (NIHL) and oxidative injury; however, no investigation has focused specifically on the subgroup of NIHL associated tinnitus patients. We aimed to evaluate the effectiveness of zinc supplementation in treating NIHL associated tinnitus. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.009DOI Listing
February 2019

The efficacy and safety of Sipjeondaebo-tang in Korean patients with cold hypersensitivity in the hands and feet: a protocol for a pilot, randomized, double-blind, placebo-controlled, parallel-group clinical trial.

Trials 2019 Apr 15;20(1):217. Epub 2019 Apr 15.

Department of Science in Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea.

Background: Cold hypersensitivity in the hands and feet (CHHF) is frequent in Asian countries including Korea. The quality of life can be degraded by the symptoms of CHHF. In particular, gynecological disorders such as menstrual pain, infertility, leucorrhea, and irregular bleeding may be related to CHHF. Read More

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http://dx.doi.org/10.1186/s13063-019-3286-7DOI Listing

A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence.

BMC Genomics 2019 Apr 15;20(1):290. Epub 2019 Apr 15.

Department of Molecular Genetics and Cell Biology and Ludwig Center for Metastasis Research, The University of Chicago, 929 East 57th Street, GCIS W522A, Chicago, IL, 60637, USA.

Background: Diverse stresses including genotoxic therapy can induce proliferating cancer cells to undergo cellular senescence and take on the characteristic phenotypes of replicative cellular aging. This accelerated or therapy-induced senescence has been alternatively proposed to contribute to therapeutic efficacy or resistance. Toward better understanding this cell state, we sought to define the core transcriptome of accelerated senescence in cancer cells. Read More

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http://dx.doi.org/10.1186/s12864-019-5653-xDOI Listing

Effect of Water Precautions on Otorrhea Incidence after Pediatric Tympanostomy Tube: Randomized Controlled Trial Evidence.

Otolaryngol Head Neck Surg 2019 Apr 16:194599819844487. Epub 2019 Apr 16.

8 Department of Otolaryngology, SUNY Downstate Medical Center, Brooklyn, New York, USA.

Objectives: Tympanostomy with ventilation tube insertion is the most common otologic surgery. Many surgeons recommend water precautions, although its utility is questioned. We aimed to investigate if water precautions reduce the rate of otorrhea after transtympanic tube insertion. Read More

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http://dx.doi.org/10.1177/0194599819844487DOI Listing

Pediatric Tracheostomy Decannulation: 11-Year Experience.

Otolaryngol Head Neck Surg 2019 Apr 16:194599819842164. Epub 2019 Apr 16.

1 Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.

Objective: To determine the successful decannulation rate with a published pediatric tracheostomy decannulation protocol.

Study Design: Case series with chart review.

Setting: A single tertiary care institution. Read More

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http://dx.doi.org/10.1177/0194599819842164DOI Listing

Barriers Pushed Aside: Insights on Career and Family Success from Women Leaders in Academic Otolaryngology.

Otolaryngol Head Neck Surg 2019 Apr 16:194599819841608. Epub 2019 Apr 16.

2 Valora Consulting, Seattle, Washington, USA.

Objective: Although the literature adequately identifies the current gender inequality that exists in academic otolaryngology and describes the barriers to advancement of women in academic medicine, there is little information regarding the daily details of how successful women in academic otolaryngology achieve work-life balance. This study was designed to better understand how women in academic otolaryngology achieve work-life balance while negotiating family and childrearing commitments, clinical workload, and scholarly activity, as well as to highlight coping strategies and behaviors that women have used to achieve these successes.

Study Design: Qualitative research design. Read More

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http://dx.doi.org/10.1177/0194599819841608DOI Listing

Improvement of otoendoscopic surgery for epitympanic cholesteatoma invading the mastoid.

Acta Otolaryngol 2019 Apr 16:1-5. Epub 2019 Apr 16.

a Department of Otolaryngology, Head and Neck Surgery , Institute of Otolaryngology of PLA, Chinese PLA General Hospital , Beijing , PR China.

Background: In recent years, the otoendoscopic surgery for epitympanic cholesteatoma has achieved great development, but it still has some disadvantages.

Objective: This work aims to improve otoendoscopic surgery for epitympanic cholesteatoma invading the mastoid to retain the normal structure of the middle ear as much as possible.

Methods: We classified the patients according to the lesion scope and applied different strategies of using the combination of otoendoscope and microscope. Read More

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https://www.tandfonline.com/doi/full/10.1080/00016489.2019.1
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http://dx.doi.org/10.1080/00016489.2019.1597985DOI Listing
April 2019
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A Hyalinizing Clear Cell Carcinoma of the Base of Tongue.

Ear Nose Throat J 2019 Apr 15:145561319840513. Epub 2019 Apr 15.

2 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, College of Medicine, the Pennsylvania State University, Hershey, PA, USA.

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http://dx.doi.org/10.1177/0145561319840513DOI Listing

Otologic Manifestations of Immunoglobulin G4-Related Disease.

Ear Nose Throat J 2019 Apr 15:145561319842852. Epub 2019 Apr 15.

2 Department of Otolaryngology, Loma Linda University Health, Loma Linda, CA, USA.

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http://dx.doi.org/10.1177/0145561319842852DOI Listing

Upper Esophageal Sphincter Dilation for Recalcitrant Dysphagia Secondary to Dermatomyositis.

Ear Nose Throat J 2019 Apr 15:145561319842511. Epub 2019 Apr 15.

1 Department of Otolaryngology, Head and Neck Surgery, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1177/0145561319842511DOI Listing

Pleomorphic Adenoma of the Trachea.

Ear Nose Throat J 2019 Apr 15:145561319840189. Epub 2019 Apr 15.

2 Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA, USA.

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http://dx.doi.org/10.1177/0145561319840189DOI Listing