1,660 results match your criteria Journal of Investigative Medicine[Journal]


Decitabine shows synergistic effects with arsenic trioxide against myelodysplastic syndrome cells via endoplasmic reticulum stress-related apoptosis.

J Investig Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.

Most of the International Prognostic Scoring System (IPSS) high-risk patients with myelodysplastic syndrome partly responded to hypomethylating therapy even with transient remission, while arsenic trioxide (ATO) had partial effect in patients with MDS. Therefore, we sought to investigate the effects and possible mechanisms of the combination of ATO and decitabine (DAC) in MDS cells. In our study, the MUTZ-1 and SKM-1 cells were treated with ATO, DAC or both. Read More

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http://dx.doi.org/10.1136/jim-2018-000953DOI Listing
March 2019
1 Read

Prevalence of human papilloma virus in oropharyngeal, tongue and lip squamous cell carcinoma: an experience from the Egyptian National Cancer Institute.

J Investig Med 2019 Mar 13. Epub 2019 Mar 13.

Surgical Pathology, National Cancer Institute, Cairo, Egypt.

Human papilloma virus (HPV) is now a well-known risk factor for head and neck cancer besides smoking and alcohol. Most studies mentioned that patients affected with high-risk HPV cancers have a better outcome, and many clinical trials are trying to prove that such group of patients can receive a different and less aggressive treatment than the HPV-negative group. Although such field has received great interest within different countries and continents, African and Egyptian populations are not yet well studied within the literature. Read More

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http://dx.doi.org/10.1136/jim-2018-000968DOI Listing
March 2019
1 Read

Effect of acute exercise on postprandial endothelial function in postmenopausal women: a randomized cross-over study.

J Investig Med 2019 Mar 5. Epub 2019 Mar 5.

Kinesiology, Texas Christian University, Fort Worth, Texas, USA.

High-sugar intake may cause endothelial dysfunction. It is unknown if a bout of aerobic exercise improves endothelial dysfunction caused by a high-sugar meal in postmenopausal women. This study evaluated if prior aerobic exercise attenuates postprandial endothelial dysfunction in postmenopausal women. Read More

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http://dx.doi.org/10.1136/jim-2019-000992DOI Listing

Low serum magnesium is associated with faster decline in kidney function: the Dallas Heart Study experience.

J Investig Med 2019 Mar 2. Epub 2019 Mar 2.

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, UT Southwestern Medical Center, Dallas, TX, USA.

Hypomagnesemia associates with inflammation and risk of diabetes and hypertension, which may contribute to kidney function decline. We hypothesized that low serum magnesium (SMg) levels independently associate with a significant decline in estimated glomerular filtration rate (eGFR). We analyzed SMg levels in 2056 participants from the Dallas Heart Study, a longitudinal, population-based, multiethnic, cohort study involving residents of Dallas County, Texas, USA. Read More

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http://dx.doi.org/10.1136/jim-2018-000966DOI Listing
March 2019
1 Read

Integration of telehealth services in the healthcare system: with emphasis on the experience of patients living with HIV.

J Investig Med 2019 Mar 2. Epub 2019 Mar 2.

Infectious Diseases, Michael E. DeBakey VAMC, Houston, Texas, USA.

The US Health Resources and Services Administration defines telehealth as the use of electronic information and telecommunications technologies to support long-distance clinical healthcare, patient and professional health-related education, public health and health administration. Many studies have supported the use of telehealth to increase convenience to patients, improve patient satisfaction, diminish healthcare disparities, and reduce cost that will ultimately lead to improvement in clinical outcomes and quality of care. However, guaranteeing confidentiality, educating patients and providers, and obtaining insurance reimbursement are some of the challenges that face the implementation of telehealth program. Read More

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http://dx.doi.org/10.1136/jim-2018-000872DOI Listing
March 2019
1 Read

Emergency management of adrenal insufficiency in children: advocating for treatment options in outpatient and field settings.

J Investig Med 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota, USA.

Adrenal insufficiency (AI) remains a significant cause of morbidity and mortality in children with 1 in 200 episodes of adrenal crisis resulting in death. The goal of this working group of the Pediatric Endocrine Society Drug and Therapeutics Committee was to raise awareness on the importance of early recognition of AI, to advocate for the availability of hydrocortisone sodium succinate (HSS) on emergency medical service (EMS) ambulances or allow EMS personnel to administer patient's HSS home supply to avoid delay in administration of life-saving stress dosing, and to provide guidance on the emergency management of children in adrenal crisis. Currently, hydrocortisone, or an equivalent synthetic glucocorticoid, is not available on most ambulances for emergency stress dose administration by EMS personnel to a child in adrenal crisis. Read More

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http://dx.doi.org/10.1136/jim-2019-000999DOI Listing
February 2019
3 Reads

Coronary artery lesion risk and mediating mechanism in children with complete and incomplete Kawasaki disease.

J Investig Med 2019 Feb 25. Epub 2019 Feb 25.

Institute of Cardiovascular Development and Translation Medicine, Wenzhou Medical University, Wenzhou, China.

To compare the risk of coronary artery lesions (CAL) in children with complete and incomplete Kawasaki disease (KD) before and after immunoglobulin therapy and explore the mediation mechanisms underlying this association. All patients with KD admitted to the Wenzhou Medical University affiliated Yuying Children's Hospital were divided into complete and incomplete KD groups. The independent effect of KD type on the risk of CAL and the intermediate effect of admission time on the association between KD type and CAL were assessed. Read More

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http://dx.doi.org/10.1136/jim-2018-000898DOI Listing
February 2019
2 Reads

Depletion of death-associated protein-3 induces chemoresistance in gastric cancer cells through the β-catenin/LGR5/Bcl-2 axis.

J Investig Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.

Previously, we demonstrated that death-associated protein-3 (DAP3) loss drives chemoresistance in gastric cancer cells. In the present study, we aimed to determine the underlying molecular mechanism. The effect of DAP3 silencing on β-catenin signaling was assessed. Read More

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http://dx.doi.org/10.1136/jim-2018-000934DOI Listing
February 2019
1 Read

Mevalonate signaling, COPD and cancer: the statins and beyond.

J Investig Med 2019 Apr 20;67(4):711-714. Epub 2019 Feb 20.

Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Evidence suggests that smoking confers a persistent and/or exaggerated inflammatory response in the lungs that, with underlying genetic susceptibility, may result in lung remodeling and impaired repair. The innate immune response to smoking described above, which is modified by the mevalonate pathway, provides a plausible pathogenic link between the development of chronic obstructive pulmonary disease and lung cancer. The mevalonate pathway modifies innate responsiveness through important intracellular signaling molecules called guanine phosphate transferases (GTPases) such as Rho-A. Read More

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http://dx.doi.org/10.1136/jim-2018-000829DOI Listing
April 2019
2 Reads

Secreted frizzled-related protein 5 suppresses aggressive phenotype and reverses docetaxel resistance in prostate cancer.

J Investig Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Urology, Wujin Hospital Affiliated to Jiangsu University, Changzhou, China.

Secreted frizzled-related protein 5 (SFRP5) has been reported to be downregulated in prostate cancer. However, its biological role in this malignancy has not been clarified yet. In the present study, we performed SFRP5 overexpression experiments to determine its function in prostate cancer cell growth, invasion, tumorigenesis, and docetaxel sensitivity. Read More

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http://dx.doi.org/10.1136/jim-2018-000849DOI Listing
February 2019
1 Read
1.503 Impact Factor

Targeting cholesterol metabolism in glioblastoma: a new therapeutic approach in cancer therapy.

J Investig Med 2019 Apr 14;67(4):715-719. Epub 2019 Feb 14.

Department of Human Anatomy and Cell Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor known with a poor survival rate despite current advances in the field of cancer. Additional research into the pathophysiology of GBM is urgently needed given the devastating nature of this disease. Recent studies have revealed the unique cellular physiology of GBM cells as compared with healthy astrocytes. Read More

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http://dx.doi.org/10.1136/jim-2018-000962DOI Listing
April 2019
3 Reads
1.503 Impact Factor

Atrial dysplasia in the atria of humans without cardiovascular disease.

J Investig Med 2019 Feb 14. Epub 2019 Feb 14.

University Heart Center Zürich, Zürich, Switzerland.

Research on atrial histology of humans without cardiovascular disease is scarce. Therefore, our aim was to study human atrial histology in subjects without cardiovascular disease. Histology of the right atrium, left atrium or atrial septum was studied in eight patients (one newborn infant and seven adults) who died of a non-cardiac cause and who were not known to suffer from any cardiovascular pathology. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000916
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http://dx.doi.org/10.1136/jim-2018-000916DOI Listing
February 2019
6 Reads

Therapeutic targets for the anemia of predialysis chronic kidney disease: a meta-analysis of randomized, controlled trials.

J Investig Med 2019 Feb 11. Epub 2019 Feb 11.

Department of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Anemia is one of the major complications in predialysis patients with chronic kidney disease (CKD). A clearer cognition of the prognostic impact of hemoglobin (Hb) or hematocrit (Hct) target on the outcomes of predialysis patients with CKD is significant. This article aims to establish the suitable hemoglobin target to provide clinical guidance. Read More

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http://dx.doi.org/10.1136/jim-2018-000915DOI Listing
February 2019
2 Reads

Development of a prediction model for 1-year poor prognosis in patients with acute ischemic stroke.

J Investig Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, China.

The goals of this study were to develop a new prediction model to predict 1-year poor prognosis (death or modified Rankin scale score of ≥3) in patients with acute ischemic stroke (AIS) and to compare the performance of the new prediction model with other prediction scales. Baseline data of 772 patients with AIS were collected, and univariate and multivariate logistic regression analyses were performed to identify independent risk factors for 1-year poor prognosis in patients with AIS. The area under the receiver operating characteristics curve (AUC) value of the new prediction model and the THRIVE, iScore and ASTRAL scores was compared. Read More

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http://dx.doi.org/10.1136/jim-2018-000883DOI Listing
February 2019

Suboptimal osteoporosis evaluation and treatment in older men with and without additional high-risk factors for fractures.

J Investig Med 2019 Apr 5;67(4):743-749. Epub 2019 Feb 5.

Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.

We compared osteoporosis case-finding, evaluation and treatment in groups of Older Men and Older Women with age alone as a significant risk for fracture and Older Men with Higher Risk (older men additionally having previous hip fracture, corticosteroid use or androgen deprivation therapy). We studied 13,704 older men and women (≥70 years old) receiving care at a Veterans Affairs medical center from January 2000 to August 2010 whose 10-year hip fracture risk was assessed by limited FRAX score. The main outcome measures were the proportion of patients who had bone mineral density (by dual-energy X-ray absorptiometry [DXA]) and serum 25-hydroxy vitamin D (25-OH D) measurements performed, and calcium/vitamin D or bisphosphonates prescribed. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000907
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http://dx.doi.org/10.1136/jim-2018-000907DOI Listing
April 2019
16 Reads

Association between trace element concentrations and anemia in patients with chronic kidney disease: a cross-sectional population-based study.

J Investig Med 2019 Feb 4. Epub 2019 Feb 4.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.

Anemia is common in chronic kidney disease (CKD) and may be affected by trace element concentrations. While the concentrations of trace elements are known to be altered in CKD, the relationship between trace element and hemoglobin concentrations has not been systematically investigated in a large cohort. This study aims to examine associations between trace element concentrations and anemia in patients with CKD. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000833
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http://dx.doi.org/10.1136/jim-2018-000833DOI Listing
February 2019
7 Reads

Outcomes from an elective medical student Research Scholarly Concentration program.

J Investig Med 2019 Feb 4. Epub 2019 Feb 4.

School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA.

To examine how to increase research career outcomes among medical graduates, we analyzed the impact of the Research Scholarly Concentration at The George Washington University School of Medicine and Health Sciences. Residency placement, subsequent scholarship, and career outcomes were compared among 670 graduates who participated in the elective Clinical and Translational Research Scholarly Concentration or no Concentration between 2009 and 2018. We conducted a retrospective study of residency match (highly selective vs less selective), job type (academic vs non-academic), and postmedical school publications (any vs none). Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000943
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http://dx.doi.org/10.1136/jim-2018-000943DOI Listing
February 2019
5 Reads

Delayed febrile response with bloodstream infections in patients with continuous-flow left ventricular assist devices.

J Investig Med 2019 Mar 29;67(3):653-658. Epub 2019 Jan 29.

Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Bloodstream infections (BSIs) are common in patients with continuous-flow left ventricular assist devices (CF-LVADs). Whether CF-LVADs modulate the febrile response to BSIs is unknown. We retrospectively compared the febrile response to BSIs in patients with heart failure (HF) with CF-LVADs versus a control population of patients with HF receiving inotropic infusions. Read More

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http://dx.doi.org/10.1136/jim-2018-000893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391164PMC

Event dependence in the analysis of cardiovascular readmissions postpercutaneous coronary intervention.

J Investig Med 2019 Jan 18. Epub 2019 Jan 18.

Baylor Heart and Vascular Institute, Baylor University Medical Center at Dallas, Dallas, Texas, USA.

Recurrent hospitalizations are common in longitudinal studies; however, many forms of cumulative event analyses assume recurrent events are independent. We explore the presence of event dependence when readmissions are spaced apart by at least 30 and 60 days. We set up a comparative framework with the assumption that patients with emergency percutaneous coronary intervention (PCI) will be at higher risk for recurrent cardiovascular readmissions than those with elective procedures. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000873
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http://dx.doi.org/10.1136/jim-2018-000873DOI Listing
January 2019
3 Reads

Effects of different types and frequencies of physical activity on the homeostatic model assessment of insulin resistance.

J Investig Med 2019 Jan 18. Epub 2019 Jan 18.

Institute of Health Services Research, Yonsei University, Seoul, Republic of Korea.

This study analyzed the type and frequency of physical activity that most effectively reduces the homeostatic model assessment of insulin resistance (HOMA2-IR) among adults (≥19 years) in Asia. We used national representative data from 1645 men and 2272 women who participated in the Korea National Health and Nutrition Examination Survey in 2015 were included in the analysis. The effects of different types and frequencies of physical activity on HOMA2-IR were investigated using a multiple regression analysis. Read More

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http://dx.doi.org/10.1136/jim-2018-000885DOI Listing
January 2019
1 Read

Elevated serum IL-35 levels in rheumatoid arthritis are associated with disease activity.

J Investig Med 2019 Mar 18;67(3):707-710. Epub 2019 Jan 18.

Department of Rheumatology and Immunology, First Affiliated Hospital of China Medical University, Shenyang, China.

To investigate serum interleukin (IL)- 35 levels in patients with rheumatoid arthritis (RA) and to describe the association between serum IL-35 levels and clinical parameters: erythrocyte sedimentation rate (ESR), C reactive protein (CRP), global health on Visual Analog Scale, Disease Activity Score in 28 joints based on ESR (DAS28-ESR), rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (ACPAs). The study included 129 patients with RA and 83 healthy controls. Serum IL-35 levels were detected by ELISA. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000814
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http://dx.doi.org/10.1136/jim-2018-000814DOI Listing
March 2019
13 Reads

Role of CT-guided transthoracic biopsy in the diagnosis of mycobacterial infection.

J Investig Med 2019 Jan 11. Epub 2019 Jan 11.

Division of Pulmonology, Department of Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Mycobacterial infection(MI) is sometimes diagnosed using CT-guided transthoracic needle biopsy (TNB). However, the exact role of CT-guided TNB in this diagnostic process is not clearly known. The purpose of this study is to analyze the role of CT-guided TNB in patients with MI who present with a focal lung lesion. Read More

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http://dx.doi.org/10.1136/jim-2018-000887DOI Listing
January 2019
2 Reads

Monoclonal B-cell lymphocytosis and prostate cancer: incidence and effects of radiotherapy.

J Investig Med 2019 Apr 11;67(4):779-782. Epub 2019 Jan 11.

Hematology and Stem cell Transplantation Unit, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy.

Monoclonal B-cells lymphocytosis (MBL) is a benign condition that may precede chronic lymphocytic leukemia (CLL), not rarely present in peripheral blood of healthy elderly people, among which there is also a male prevalence. Though CLL has been associated with various types of solid tumors, including prostate cancer (PC), no data exist about the relationship between PC and MBL. We studied the frequency of CLL-like MBL clones in a group of 48 patients affected by PC and followed them during and after whole-pelvis radiotherapy (WPRT) treatment. Read More

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http://dx.doi.org/10.1136/jim-2018-000902DOI Listing
April 2019
2 Reads

Serum heart-type fatty acid-binding protein decreases and soluble isoform of suppression of tumorigenicity 2 increases significantly by long-term physical activity.

J Investig Med 2018 Dec 27. Epub 2018 Dec 27.

SKA-RZ Bad Tatzmannsdorf, Bad Tatzmannsdorf, Austria.

The aim of this prospective study was to investigate the influence of long-term physical activity on biomarkers for myocyte ischemia (heart-type fatty acid-binding protein, H-FABP), matrix remodelling/vascular stress (soluble isoform of suppression of tumorigenicity 2, sST2) and inflammation (soluble urokinase-type plasminogen activator receptor, suPAR). In this prospective observational study 109 subjects were recruited, 98 completed the study. Subjects were asked to perform exercise within the calculated training pulse for 8 months. Read More

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http://dx.doi.org/10.1136/jim-2018-000913DOI Listing
December 2018
1 Read

Long-term efficacy of rifaximin to manage the symptomatic uncomplicated diverticular disease of the colon.

J Investig Med 2019 Apr 27;67(4):767-770. Epub 2018 Dec 27.

Gastroenterology Service, ASL BAT, Andria, Italy.

Although rifaximin is currently advised in managing symptomatic uncomplicated diverticular disease (SUDD) of the colon, no long-term data are available. This retrospective study assessed the outcome of a large cohort of patients with SUDD, treated with rifaximin, during an 8-year follow-up. The study group (group A) included 346 patients with SUDD (median age 64 years, IQR 58-69, 62. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000901
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http://dx.doi.org/10.1136/jim-2018-000901DOI Listing
April 2019
12 Reads

The characteristics and clinical significance of mucin levels in bronchoalveolar lavage fluid of patients with interstitial lung disease.

J Investig Med 2019 Apr 19;67(4):761-766. Epub 2018 Dec 19.

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.

To investigate the expression and clinical significance of secretory mucins in patients with interstitial lung disease (ILD). The bronchoalveolar lavage fluid (BALF) concentrations of mucins (MUCs) from 27 patients with ILD, 6 patients with lung cancer, 8 patients with pleural effusion and 9 patients with bronchiectasis were determined by ELISA. The concentration of MUC5AC was significantly increased in patients with ILD (12. Read More

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http://dx.doi.org/10.1136/jim-2018-000785DOI Listing
April 2019
4 Reads
1.503 Impact Factor

Copeptin levels upon corticosteroid treatment in acute community-acquired pneumonia.

J Investig Med 2019 Feb 16;67(2):e1. Epub 2018 Dec 16.

Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000886
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http://dx.doi.org/10.1136/jim-2018-000886DOI Listing
February 2019
12 Reads

A novel scoring system for assessing the severity of electrolyte and acid-base disorders and predicting outcomes in hospitalized patients.

J Investig Med 2019 Apr 6;67(4):750-760. Epub 2018 Dec 6.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

Electrolyte and acid-base disorders are commonly seen in critically ill and other hospitalized patients. A scoring system is needed to assess the severity of electrolyte and acid-base disorders and to predict outcome in hospital patients. Herein, we prospectively enrolled a total of 322,046 patients, including 84,700 patients in the derivation cohort and 237,346 in the validation cohort, in a large, tertiary hospital in East China from 2014 to 2017. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000900
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http://dx.doi.org/10.1136/jim-2018-000900DOI Listing
April 2019
9 Reads

Predisposing factors of childhood Henoch-Schönlein purpura in Anhui province, China.

J Investig Med 2019 Apr 6;67(4):771-778. Epub 2018 Dec 6.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Henoch-Schönlein purpura (HSP) is a common autoimmune vasculitis in childhood. The detailed pathogenesis of HSP is still unclear, whereas several types of predisposing factors have been proved to be the initial step. The objectives of present study were to analyze the distribution of predisposing factors, association of the predisposing factors with clinical manifestations and HSP relapse/recurrence. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000906
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http://dx.doi.org/10.1136/jim-2018-000906DOI Listing
April 2019
18 Reads
1.503 Impact Factor

Metabolic syndrome is a sequela of radiation exposure in hypothalamic obesity among survivors of childhood brain tumors.

J Investig Med 2019 Feb 9;67(2):295-302. Epub 2018 Dec 9.

University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Survivors of childhood brain tumors may be at risk for early onset of metabolic syndrome, possibly secondary to surgery and/or radiation exposure. This study examines effects of radiation exposure to hypothalamus-pituitary-adrenal axis (HPA) on metabolic risk among survivors of childhood brain tumors. One hundred forty-two met inclusion criteria; 60 had tumor surgery plus radiation exposure (1 Gray (Gy)) to HPA. Read More

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http://dx.doi.org/10.1136/jim-2018-000911DOI Listing
February 2019
4 Reads

Association of triglyceride to HDL cholesterol ratio with cardiometabolic outcomes.

J Investig Med 2019 Mar 9;67(3):663-668. Epub 2018 Dec 9.

Stanford University Department of Medicine, Stanford, California, USA.

Electronic medical records (EMRs) offer a potential opportunity to identify patients at high risk for cardiometabolic disease, which encompasses type 2 diabetes and cardiovascular disease (CVD). The objective of this retrospective cohort study is to use information gathered from EMR to investigate the association between triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) and cardiometabolic outcomes in a general population of subjects over 50 years of age during a follow-up period of 8-9 years. TG/HDL-C was recorded for each of 1428 subjects in 2008, and diagnoses of type 2 diabetes and CVD were recorded through chart review until 2017. Read More

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http://dx.doi.org/10.1136/jim-2018-000869DOI Listing
March 2019
1 Read

Gender differences in cardiovascular risk assessment in elderly adults in Ecuador: evidence from a national survey.

Authors:
Ivan Sisa

J Investig Med 2019 Apr 5;67(4):736-742. Epub 2018 Dec 5.

School of Medicine, College of Health Sciences, Universidad San Francisco de Quito, Quito, Ecuador.

The present study aimed to predict the risk of developing cardiovascular disease (CVD) over a 5-year period and how it might vary by sex in an ethnically diverse population of older adults. We used a novel CVD risk model built and validated in older adults named the Systematic Coronary Risk Evaluation in Older Persons (SCORE OP). A population-based study analyzed a total of 1307 older adults. Read More

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http://dx.doi.org/10.1136/jim-2018-000789DOI Listing
April 2019
2 Reads

Pregnancy-associated plasma protein-a is associated with subclinical atherosclerosis in men with HIV infection.

J Investig Med 2018 Nov 28. Epub 2018 Nov 28.

Cardiology, University of Health Science, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

The pathophysiology of an early and accelerated atherosclerotic process is complex and multifactorial in HIV-infected men compared with HIV-non-infected men. Several biomarkers have been well studied in the detection of the early stage of atherosclerosis, but studies are limited in HIV-infected men. The objective of this study was to investigate the association between serum pregnancy-associated plasma protein-A (PAPP-A) and carotid intima-media wall thickness (CIMT) in asymptomatic HIV-infected men. Read More

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http://dx.doi.org/10.1136/jim-2018-000859DOI Listing
November 2018
2 Reads

Risk factors for cardiac rupture complicating myocardial infarction: a PRISMA meta-analysis and systematic review.

J Investig Med 2019 Apr 28;67(4):720-728. Epub 2018 Nov 28.

Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.

Cardiac rupture (CR) is a complication of acute myocardial infarction (AMI) that is associated with a high mortality rate. This study aimed to identify the risk factors for CR in patients with AMI. Medline, Cochrane, EMBASE, and Google Scholar databases were searched for relevant literature published through September 16, 2018. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000841
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http://dx.doi.org/10.1136/jim-2018-000841DOI Listing
April 2019
24 Reads

Associations of hormonal contraceptives and infertility medications on the risk of venous thromboembolism, ischemic stroke, and cardiovascular disease in women.

J Investig Med 2019 Apr 26;67(4):729-735. Epub 2018 Nov 26.

Department of Obstetrics and Gynecology, Min-Sheng General Hospital, Taoyuan, Taiwan.

The purpose of this study was to examine the relations of hormonal contraceptives and infertility drugs with the risk of venous thromboembolism (VTE), deep vein thrombosis (DVT), pulmonary embolism (PE), ischemic stroke, and cardiovascular disease. The Taiwan National Health Institute Research Database was searched for women who had taken hormonal contraceptives or infertility medications from 2000 to 2010. The two groups were age and index date matched with controls (1:4 ratios). Read More

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http://dx.doi.org/10.1136/jim-2018-000750DOI Listing
April 2019
4 Reads

Continuous low-dose everolimus shrinkage tuberous sclerosis complex-associated renal angiomyolipoma: a 48-month follow-up study.

J Investig Med 2019 Mar 18;67(3):686-690. Epub 2018 Nov 18.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Tuberous sclerosis complex (TSC) is a rare disease that causes multisystem benign neoplasm, induced by dysregulation of the mammalian target of the rapamycin pathway (mTOR). This study aimed to examine the effects of continuous low-dose everolimus, a potent and selective inhibitor of mTOR, on the treatment of TSC-associated renal angiomyolipoma (AML). Between July 2013 and August 2017, 11 patients with TSC-AML were enrolled for an everolimus therapy protocol. Read More

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http://dx.doi.org/10.1136/jim-2018-000865DOI Listing
March 2019
12 Reads

Update on the biology and management of renal cell carcinoma.

Authors:
Janice P Dutcher

J Investig Med 2019 Jan 18;67(1):1-10. Epub 2018 Nov 18.

Renal cell cancer (RCC) (epithelial carcinoma of the kidney) represents 2%-4% of newly diagnosed adult tumors. Over the past 2 decades, RCC has been better characterized clinically and molecularly. It is a heterogeneous disease, with multiple subtypes, each with characteristic histology, genetics, molecular profiles, and biologic behavior. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000918
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http://dx.doi.org/10.1136/jim-2018-000918DOI Listing
January 2019
13 Reads

Fractional excretion of phosphorus and vascular calcification in stage 3 chronic kidney disease.

J Investig Med 2019 Mar 14;67(3):674-680. Epub 2018 Nov 14.

Internal Medicine Unit, Hospital Virgen de la Victoria, Málaga, Spain.

The role of renal excretion of Pi in relation to vascular calcification (VC) in patients in the early stages of chronic kidney disease (CKD) is controversial. Thus, we determine the relation between fractional excretion of phosphorus (FEP) and VC, measured using two methods in a cross-sectional study of patients with stage 3 CKD. We recorded demographic data, anthropometry, comorbidities and active treatment. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000852
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http://dx.doi.org/10.1136/jim-2018-000852DOI Listing
March 2019
16 Reads

Changes in calcium channel proteins according to magnesium sulfate administration in placentas from pregnancies with pre-eclampsia or fetal growth restriction.

J Investig Med 2019 Feb 9;67(2):319-326. Epub 2018 Nov 9.

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

We aimed to evaluate the changes in plasma membrane Ca-ATPase (PMCA) and sarcoendoplasmic reticulum CA-ATPase (SERCA-2) according to the antepartal magnesium sulfate (MgSO) administration in the placentas from pregnancies with pre-eclampsia (PE) or fetal growth restriction (FGR). Pregnant women were classified as follows: (group 1) pregnancies without PE or FGR (n=16), (group 2) pregnancies with PE or FGR but without MgSO administration (n=14), and (group 3) pregnancies with PE or FGR and with MgSO administration (n=28). We observed the localization of PMCA and SERCA-2 in placentas and compared its expression among 3 groups. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000844
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http://dx.doi.org/10.1136/jim-2018-000844DOI Listing
February 2019
14 Reads

Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus.

J Investig Med 2019 Mar 31;67(3):681-685. Epub 2018 Oct 31.

Public Health andCommunity Medicine Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.

Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000840
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http://dx.doi.org/10.1136/jim-2018-000840DOI Listing
March 2019
4 Reads

Clinical features of patients with male breast cancer in Shanxi province of China from 2007 to 2016.

J Investig Med 2019 Mar 27;67(3):699-705. Epub 2018 Oct 27.

Department of Etiology and Tumor Marker Laboratory, Shanxi Cancer Hospital, Shanxi, China.

This study aims to understand the clinical features, treatment, and prognosis of patients with male breast cancer (MBC) in Shanxi province of China from 2007 to 2016. Data for 77 patients with MBC were collected for analysis. Immunohistochemistry, pathological results, and other data such as demographic characteristics (age, marital status, smoking history, drinking history, and family history of cancer) as well as clinical data were investigated by retrieving information from the patients' medical records. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000823
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http://dx.doi.org/10.1136/jim-2018-000823DOI Listing
March 2019
7 Reads

Statins: a new approach to combat temozolomide chemoresistance in glioblastoma.

J Investig Med 2018 Dec 27;66(8):1083-1087. Epub 2018 Oct 27.

Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Patients with glioblastoma multiforme (GBM) have an average life expectancy of approximately 15 months. Recently, statins have emerged as a potential adjuvant cancer therapy due to their ability to inhibit cell proliferation and induce apoptosis in many types of cancer. The exact mechanisms that mediate the inhibitory actions of statins in cancer cells are largely unknown. Read More

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http://dx.doi.org/10.1136/jim-2018-000874DOI Listing
December 2018
17 Reads
1.503 Impact Factor

Prevalence and risk factors of acquired long QT syndrome in hospitalized patients with chronic kidney disease.

J Investig Med 2019 Feb 26;67(2):289-294. Epub 2018 Oct 26.

First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Patients with chronic kidney disease (CKD) have a high risk of fatal arrhythmias. The extended severe corrected QT (QTc) interval is a hallmark of ventricular arrhythmias and sudden cardiac death. The objective of this study was to evaluate the prevalence of acquired long QT syndrome (aLQTS) in hospitalized patients with CKD and search for potential risk factors to improve clinical risk stratification in patients with CKD. Read More

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http://dx.doi.org/10.1136/jim-2018-000798DOI Listing
February 2019
6 Reads

Experimental study of the inhibition effect of CXCL12/CXCR4 in malignant pleural mesothelioma.

J Investig Med 2019 Feb 26;67(2):338-345. Epub 2018 Oct 26.

Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, California, USA.

Previous studies have demonstrated that CXCL12/CXCR4 axis is closely related to tumors such as malignant pleural mesothelioma (MPM). This research was conducted in order to detect whether CXCL12/CXCR4 inhibitors could restrain MPM and have a synergistic effect with chemotherapy, also to investigate the relationship of CXCL12/CXCR4 with other gene expressions in MPM. Forty mice were injected MPM cells and randomly divided into four groups: the PBS (control group), AMD3100 (CXCR4-CXCL12 antagonist), pemetrexed and AMD3100 plus pemetrexed. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000839
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http://dx.doi.org/10.1136/jim-2018-000839DOI Listing
February 2019
18 Reads
1.503 Impact Factor

Low-density lipoprotein level on admission is not associated with postintravenous thrombolysis intracranial hemorrhage in patients with acute ischemic stroke.

J Investig Med 2019 Mar 26;67(3):659-662. Epub 2018 Oct 26.

Department of Neurology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.

Intravenous thrombolysis with the tissue plasminogen activator (tPA) is the gold standard for acute ischemic stroke. However, its application is limited because of the concern of the post-tPA intracranial hemorrhage (ICH). Low low-density lipoprotein (LDL) has been speculated to increase the risk of hemorrhagic transformation after ischemic stroke. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000827
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http://dx.doi.org/10.1136/jim-2018-000827DOI Listing
March 2019
25 Reads
1.503 Impact Factor

Repeat radiographic imaging in patients with long bone fractures transferred to a pediatric trauma center.

J Investig Med 2019 Jan 26;67(1):59-62. Epub 2018 Oct 26.

Division of Pediatric Emergency Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

This study sought to determine the proportion of children with long bone fractures who undergo duplicate radiographic imaging after transfer to a pediatric trauma center (PTC) for further management. The secondary objective was to explore provider rationale and diagnostic yield of repeat X-rays. This was a single-site, retrospective cohort study conducted at a PTC. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000877
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http://dx.doi.org/10.1136/jim-2018-000877DOI Listing
January 2019
8 Reads

Relationship between dental loss and health outcomes among hospitalized patients with and without diabetes.

J Investig Med 2019 Mar 21;67(3):669-673. Epub 2018 Oct 21.

School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, Nevada, USA.

There is mixed evidence regarding the impact of poor dental health on cardiovascular disease and other health outcomes. Our objective was to determine the outcomes associated with poor dental health among hospitalized patients with and without diabetes mellitus (DM) at our institution. We enrolled a consecutive sample of adult patients admitted to an academic medical center. Read More

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http://dx.doi.org/10.1136/jim-2018-000842DOI Listing
March 2019
1 Read

Performance of the SteatoTest, ActiTest, NashTest and FibroTest in a multiethnic cohort of patients with type 2 diabetes mellitus.

J Investig Med 2019 Feb 10;67(2):303-311. Epub 2018 Oct 10.

Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida, USA.

Fibromax is a diagnostic tool composed of the combination of 4 non-invasive biomarker panels for the diagnosis of steatosis (SteatoTest), necrosis and inflammation (ActiTest and NashTest-2) and fibrosis (FibroTest). The purpose of this study was to assess the performance of these biomarker panels in patients with type 2 diabetes mellitus (T2DM). All patients underwent routine labs, a 75 g oral glucose tolerance test, a liver proton magnetic resonance spectroscopy (H-MRS) to measure intrahepatic triglyceride content, and a percutaneous liver biopsy to establish the diagnosis of non-alcoholic steatohepatitis (NASH) and to grade and stage the disease in those patients with non-alcoholic fatty liver disease (NAFLD) by H-MRS. Read More

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http://dx.doi.org/10.1136/jim-2018-000864DOI Listing
February 2019
6 Reads

Association between fine particulate matter and oral cancer among Taiwanese men.

J Investig Med 2019 Jan 9;67(1):34-38. Epub 2018 Oct 9.

Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.

The aim of this study was to investigate the association between fine particulate matter 2.5 (PM) and oral cancer among Taiwanese men. Four linked data sources including the Taiwan Cancer Registry, Adult Preventive Medical Services Database, National Health Insurance Research Database, and Air Quality Monitoring Database were used. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2016-000263
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http://dx.doi.org/10.1136/jim-2016-000263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352417PMC
January 2019
20 Reads

Prostate cancer aggressiveness and age: Impact of p53, BCL-2 and microvessel density.

J Investig Med 2018 Dec 7;66(8):1142-1146. Epub 2018 Oct 7.

Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, Connecticut, USA.

Older men are more likely to have advanced prostate cancer at time of their diagnosis, but whether prostate tumors are inherently (biologically) more aggressive with advancing age is uncertain. To address this gap in knowledge, we analyzed data from veterans (n=971) diagnosed with prostate cancer during 1991-1995. Factors included age, detection of prostate cancer by screening, prostate-specific antigen (PSA) level, anatomic stage, and Gleason score. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000804
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http://dx.doi.org/10.1136/jim-2018-000804DOI Listing
December 2018
8 Reads