19,468 results match your criteria Journal of Investigative Dermatology[Journal]


Dysregulation of Akt-FOXO1 pathway leads to dysfunction of regulatory T cells in psoriasis patients.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Psoriasis is a T lymphocyte-driven systemic inflammatory disease. Regulatory T (Treg) cells are essential for establishing and maintaining immune tolerance. In this study, we found that the psoriatic patients and healthy controls had comparable percentages of circulating CD4CD25FOXP3 Treg cells, but psoriatic Treg cells had reduced suppressive function. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.035DOI Listing

Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria. Electronic address:

Epidermolytic ichthyosis (EI) is a skin fragility disorder caused by dominant-negative mutations in KRT1 or KRT10. No definitive restorative therapies exist that target these genetic faults. Gene editing can be used to efficiently introduce frameshift mutations to inactivate mutant genes. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1146DOI Listing

Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, shaanxi, 710032, China. Electronic address:

Vitiligo is a cutaneous depigmentation disorder caused by the destruction of epidermal melanocytes. The generation and the skin infiltration of autoreactive CD8 cytotoxic T cells triggered by oxidative stress play a critical role in vitiligo. High-mobility group protein B1 (HMGB1) is a classic damage-associated molecular pattern (DAMP) molecule with strong proinflammatory effects in inflammatory reactions. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1148DOI Listing

Gluten challenge induces skin and small bowel relapse in long-term gluten-free diet-treated dermatitis herpetiformis.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Tampere University Hospital, Tampere, Finland; Celiac Disease Research Center, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland. Electronic address:

Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease causing an itchy, blistering rash. Skin IgA deposits are pathognomonic for DH, and the treatment of choice is a life-long gluten-free diet (GFD). Preliminary evidence suggests that there are DH patients who redevelop gluten tolerance after adherence to a GFD treatment. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1150DOI Listing
April 2019
1 Read

Tumor Endothelial Marker 1 (TEM1/endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors.

J Invest Dermatol 2019 Apr 12. Epub 2019 Apr 12.

The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; International Center of Wound Repair and Regeneration, National Cheng Kung University hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Tumor endothelial marker 1 (TEM1), also known as endosialin or CD248, is a type I transmembrane glycoprotein containing a C-type lectin-like domain. It is highly expressed in pericytes and fibroblasts. Dermal fibroblasts play a pivotal role during cutaneous wound healing, especially in the proliferative phase. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1149DOI Listing

Responses of reconstructed human epidermis to Trichophyton rubrum infection and impairment of infection by the inhibitor PD169316.

J Invest Dermatol 2019 Apr 12. Epub 2019 Apr 12.

URPHYM-NARILIS, University of Namur, Namur, Belgium. Electronic address:

Despite the threatening incidence of dermatophytosis, information is still lacking about the consequences of infection on epidermal barrier functions and about the keratinocyte responses that alert immune components. In order to identify the mechanisms involved, arthroconidia of the anthropophilic dermatophyte Trichophyton rubrum were prepared to infect reconstructed human epidermis (RHE) in vitro. Integrity of the barrier was monitored during infection by measurements of trans-epithelial electrical resistance and dye-permeation through the RHE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193147
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http://dx.doi.org/10.1016/j.jid.2019.03.1147DOI Listing
April 2019
1 Read

Silencing of PD-L2/B7-DC by Topical Application of Small Interfering RNA Inhibits Elicitation of Contact Hypersensitivity.

J Invest Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Molecular Immunology. Electronic address:

PD-L2 is a ligand for the immune checkpoint receptor PD-1, however, its regulatory function is unclear. We previously reported that silencing of CD86 in cutaneous dendritic cells (DCs) by topical siRNA application inhibits the elicitation of contact hypersensitivity (CHS). Here we investigated the effects of topical PD-L2 siRNA application on allergic skin disease. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.037DOI Listing

Abnormal glucocorticoid synthesis in the lesional skin of erythematotelangiectatic rosacea.

J Invest Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University; Department of Dermatology, Seoul National University Boramae Medical Center. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.036DOI Listing

Effects of parvovirus B19 in vitro infection on monocytes from systemic sclerosis patients: enhanced inflammatory pathways by caspase-1 activation and cytokine production.

J Invest Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, University-Hospital Policlinico of Modena, Modena, Italy.

Parvovirus B19 (B19V) has been proposed as triggering agent of some autoimmune diseases including systemic sclerosis (SSc). In this study, we investigated whether B19V infection in vitro differently activates inflammatory pathways, including those dependent on caspase-1 activation, in monocytes from SSc patients and healthy controls. We showed that B19V can infect both THP-1 cells and primary monocytes but is not able to replicate in these cells. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1144DOI Listing

'Nephrogenic' systemic fibrosis is mediated by myeloid C-C chemokine receptor 2.

J Invest Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Kidney Institute of New Mexico; University of New Mexico Health Science Center; New Mexico Veterans Administration Health Care System. Electronic address:

Gadolinium-based contrast agents are implicated in several pathologic abnormalities (long-term retention in vital organs such as the skin and brain) and are the cause of a sometimes fatal condition in patients, 'nephrogenic' systemic fibrosis (NSF). Bone marrow-derived fibrocytes and the monocyte chemoattractant protein 1 (MCP1) inflammatory pathway have been implicated as mediators of adverse effects induced by gadolinium-based contrast agents. Mechanistic studies are scant. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1145DOI Listing
April 2019
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Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus.

J Invest Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jid.2019.02.035DOI Listing
April 2019
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Disruption of the Sensory System Affects Sterile Cutaneous Inflammation in vivo.

J Invest Dermatol 2019 Apr 8. Epub 2019 Apr 8.

King's College London, Wolfson Centre for Age Related Diseases.

Increasing evidence suggests that nerve fibers responding to noxious stimuli (nociceptors) modulate immunity in a variety of tissues including the skin. Yet, a role for nociceptors in regulating sterile cutaneous inflammation remains unexplored. To tackle this question, we have developed a detailed description of the sterile inflammation caused by overexposure to UVB irradiation (i. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.037DOI Listing
April 2019
1 Read

Skin cancer early detection practices among adult survivors of childhood cancer treated with radiation.

J Invest Dermatol 2019 Apr 5. Epub 2019 Apr 5.

Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.

Because rates of skin cancer are greater among adult survivors of childhood cancer who received radiation therapy than the general population, the National Cancer Institute recommends skin self-examinations and annual physician examination. There has been no comprehensive assessment of survivor's adherence with skin cancer screening guidelines associated with skin self-examination (SSE) and physician whole-body skin examination (PSE). We conducted a cross-sectional survey of radiation-treated, adult five-year survivors of childhood cancer, diagnosed between 1970-1986, in the Childhood Cancer Survivor Study (CCSS) cohort. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.033DOI Listing
April 2019
1 Read

HOPX is a ZNF750 target that promotes late epidermal differentiation.

J Invest Dermatol 2019 Apr 5. Epub 2019 Apr 5.

Department of Dermatology, University of California- San Diego, La Jolla, CA 92093. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.03.1141DOI Listing

Hemidesmosomes and focal adhesions treadmill as separate but linked entities during keratinocyte migration.

J Invest Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Institute of Molecular and Cellular Anatomy, RWTH Aachen University, 52074 Aachen, Germany. Electronic address:

Hemidesmosomes anchor the epidermal keratin filament cytoskeleton to the extracellular matrix. They are crucial for the mechanical integrity of skin. Their role in keratinocyte migration, however, remains unclear. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1139DOI Listing
April 2019
7.216 Impact Factor

TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10.

J Invest Dermatol 2019 Mar 30. Epub 2019 Mar 30.

Dermatology Hospital, Southern Medical University, Guangzhou, China; Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Electronic address:

Keloids represent one extreme of aberrant dermal wound healing. One of the important characteristics of keloids is uncontrolled fibroblasts proliferation. However, the mechanism of excessive proliferation of fibroblasts in keloids remains elusive. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193144
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http://dx.doi.org/10.1016/j.jid.2019.03.1136DOI Listing
March 2019
3 Reads

Melanocyte hyaluronan coat fragmentation enhances the UVB-induced TLR-4 receptor signaling and expression of proinflammatory mediators IL-6, IL-8, CXCL-1 and CXCL-10 via NF-κB activation.

J Invest Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Institute of Biomedicine, School of Medicine, University of Eastern Finland, FI-70210 Kuopio, Finland.

Skin is constantly exposed to UV-radiation, the most critical risk factor for melanoma development. Hyaluronan is abundant in the epidermal extracellular matrix and may undergo degradation by UV-radiation. It is hypothesized that an intact hyaluronan coat around the cells protects against various agents including UV-radiation, while hyaluronan fragments promote inflammation and tumorigenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193139
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http://dx.doi.org/10.1016/j.jid.2019.03.1135DOI Listing
March 2019
3 Reads

Critical role of ATP-P2X7 axis in UV-induced melanogenesis.

J Invest Dermatol 2019 Mar 26. Epub 2019 Mar 26.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Purinergic signaling participates in skin physiology and pathology such as hair growth, wound healing, inflammation, pain, and skin cancer. However, few studies have investigated the involvement of purinergic signaling in skin pigmentation. This study demonstrated that extracellular adenosine 5'-triphosphate (ATP) released from keratinocytes by ultraviolet B (UVB) radiation promotes melanin production in primary human epidermal melanocytes and ex vivo skin cultures. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.031DOI Listing
March 2019
2 Reads

Identity-by-descent analysis reveals susceptibility loci for severe acne in Chinese Han cohort.

J Invest Dermatol 2019 Mar 25. Epub 2019 Mar 25.

State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, Yunnan University, Kunming, China; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China; KIZ /CUHK Joint Laboratory of Bio-resources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.03.1132DOI Listing

Contribution of STAT3 and RAD23B in primary Sézary cells to histone deacetylase inhibitor FK228 resistance.

J Invest Dermatol 2019 Mar 22. Epub 2019 Mar 22.

St. John's Institute of Dermatology, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom. Electronic address:

FK228 (Romidepsin) and suberoylanilide hydroxamic acid (SAHA, Vorinostat) are FDA-approved histone deacetylase inhibitors (HDACi) for Cutaneous T-cell Lymphoma (CTCL), including the leukemic subtype Sézary Syndrome (SS). This study investigates RAD23B and STAT3 gene perturbations in a large cohort of primary Sézary cells and the effect of FK228 treatment on tyrosine phosphorylation of STAT3 (pYSTAT3) and RAD23B expression. We report RAD23B copy number variation in 10% (12/119; p ≤ 0. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1130DOI Listing
March 2019
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Eosinophils mediate basophil-dependent allergic skin inflammation in mice.

J Invest Dermatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany. Electronic address:

The mechanisms leading to allergic skin inflammation such as atopic dermatitis or urticaria are poorly defined. Here, we used a mouse model for IgE-dependent chronic allergic inflammation (IgE-CAI) to study the role of basophils and eosinophils for induction of pathology. FcεRI expression in basophils was required for the ear swelling response and basophils promoted the expression of eosinophil recruiting chemokines in the ear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193133
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http://dx.doi.org/10.1016/j.jid.2019.03.1129DOI Listing
March 2019
3 Reads

Keratinocyte Proline-Rich Protein Deficiency in Atopic Dermatitis Leads to Barrier Disruption.

J Invest Dermatol 2019 Mar 21. Epub 2019 Mar 21.

Department of Dermatology, the University of Tokyo Graduate School of medicine, Tokyo, Japan.

Atopic dermatitis (AD) is a common inflammatory skin disease caused by interaction of genetic and environmental factors. By allelic copy number analysis at missense single-nucleotide polymorphisms on 26 genes with copy number variation, we identified significant association between atopic dermatitis and human keratinocyte proline-rich protein (hKPRP). hKPRP expression, which was localized to the upper granular layer of epidermis, was significantly decreased in AD compared to normal skin. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.030DOI Listing

Exome sequencing of ABCB5 identifies recurrent melanoma mutations that result in increased proliferative and invasive capacities.

J Invest Dermatol 2019 Mar 21. Epub 2019 Mar 21.

Laboratory of Molecular Cancer Biology, URPhyM, NARILIS, Faculty of Medicine, Department of Biomedical Sciences, University of Namur, Namur, Belgium. Electronic address:

ABCB5 is an ATP-binding cassette (ABC) transporter that was shown to confer low-level multidrug resistance in cancer. In this study, we show that ABCB5 was mutated in 13.75% of the 640 melanoma samples analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193133
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http://dx.doi.org/10.1016/j.jid.2019.01.036DOI Listing
March 2019
4 Reads

Whole-Exome Sequencing Reveals Frequent Mutations in Chromatin Remodeling Genes in Mammary and Extramammary Paget's Diseases.

J Invest Dermatol 2019 Apr 25;139(4):789-795. Epub 2018 Oct 25.

Department of Laboratory Medicine, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. Electronic address:

Paget's disease (PD) is an intraepidermal adenocarcinoma of the skin at the breast (mammary PD) or urogenital locations (extramammary PD [EMPD]). At present, there is lack of clarity on PD's pathogenesis, the relationship between its subtypes, and its lineage link with the underlying invasive carcinomas. Here we describe that mammary PD and EMPD have similar mutational profiles, with the most frequent recurrent mutations occurring in the chromatin remodeling genes, such as KMT2C (MLL3, 39%) and ARID2 (22%), with additional recurrent somatic mutations detected in genes previously not known to be mutated in cancers, such as CDCC168 (34%), FSIP2 (29%), CASP8AP2 (29%), and BIRC6 (24%). Read More

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http://dx.doi.org/10.1016/j.jid.2018.08.030DOI Listing

Cells to Surgery Quiz: April 2019.

J Invest Dermatol 2019 Apr;139(4):e39-e45

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.007DOI Listing

SnapshotDx Quiz: April 2019.

J Invest Dermatol 2019 Apr;139(4):e33-e38

Department of Dermatology and Cutaneous Surgery, University of Miami L. Miller School of Medicine, Miami, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.008DOI Listing

Erratum.

Authors:

J Invest Dermatol 2019 Apr;139(4):977

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http://dx.doi.org/10.1016/j.jid.2019.01.010DOI Listing

Erratum.

Authors:

J Invest Dermatol 2019 Apr;139(4):977

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http://dx.doi.org/10.1016/j.jid.2019.01.018DOI Listing

Large-Giant Congenital Melanocytic Nevi: Moving Beyond NRAS Mutations.

Authors:
Mitchell S Stark

J Invest Dermatol 2019 Apr;139(4):756-759

Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Brisbane, Queensland, Australia. Electronic address:

Large-giant congenital melanocytic nevi have been well characterized clinically, yet questions remain about the heterogenous phenotypes observed. Martins da Silva et al. (2018) highlight the genotypic diversity between "classic" and "spilus-like" congenital melanocytic nevi by analyzing multiple biopsy sites and matching satellite nevi. Read More

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http://dx.doi.org/10.1016/j.jid.2018.10.003DOI Listing

Gliptin-Associated Bullous Pemphigoid: A Valuable Model of the Mechanism of Breakdown of Immune Tolerance against BP180.

J Invest Dermatol 2019 Apr;139(4):755-756

Department of Dermatology, PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. Electronic address:

The study by Plaquevent et al. strongly supports the recent discovery that the use of gliptins is a risk factor for bullous pemphigoid (BP). However, regarding the phenotype of gliptin-associated BP and the necessity of gliptin withdrawal, clinical data remain scarce. Read More

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http://dx.doi.org/10.1016/j.jid.2018.11.025DOI Listing

Paget's Diseases: United by Epidermis and Epigenetics.

Authors:
Brian C Capell

J Invest Dermatol 2019 Apr;139(4):753-754

Department of Dermatology and Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

Almost 150 years have passed since Sir James Paget described the disease that bears his name, but the molecular etiology and cellular origins of Paget's disease remain poorly understood. Herein, Zhang et al. (2018) bring Paget's disease into the genomics era, providing evidence for an epidermal origin for Paget's disease, as well as a high incidence of mutations in genes encoding epigenetic regulators. Read More

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http://dx.doi.org/10.1016/j.jid.2018.10.001DOI Listing
April 2019
2 Reads

Research Techniques Made Simple: Profiling the Skin Microbiota.

J Invest Dermatol 2019 Apr;139(4):747-752.e1

Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA; Department of Microbiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

Skin is colonized by microbial communities (microbiota) that participate in immune homeostasis, development and maintenance of barrier function, and protection from pathogens. The past decade has been marked by an increased interest in the skin microbiota and its role in cutaneous health and disease, in part due to advances in next-generation sequencing platforms that enable high-throughput, culture-independent detection of bacteria, fungi, and viruses. Various approaches, including bacterial 16S ribosomal RNA gene sequencing and metagenomic shotgun sequencing, have been applied to profile microbial communities colonizing healthy skin and diseased skin including atopic dermatitis, psoriasis, and acne, among others. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.024DOI Listing

Engaging the patients' perspective in clinical trials research.

J Invest Dermatol 2019 Mar 14. Epub 2019 Mar 14.

Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.028DOI Listing

Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense.

J Invest Dermatol 2019 Mar 14. Epub 2019 Mar 14.

Department of Dermatology, University of California, San Diego, La Jolla, California, USA. Electronic address:

Dermal white adipose tissue is a unique layer of adipocytes within the reticular dermis of the skin. Recently, several nonmetabolic activities have been discovered for dWAT and its fibroblast precursors. These functions include antimicrobial defense and roles in hair cycling, wound healing, and thermogenesis. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.031DOI Listing

Imaging mass spectrometry-based lipidomic approach to classification of architectural features in nevi.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Cell Biology and Histology, Faculty of Medicine and Nursing, UPV/EHU, Leioa, Spain; Biocruces-Bizkaia Institute. Cruces University Hospital, Barakaldo, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193132
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http://dx.doi.org/10.1016/j.jid.2019.01.031DOI Listing
March 2019
3 Reads

Keratinocyte integrin α3β1 promotes secretion of IL-1α to effect paracrine regulation of fibroblast gene expression and differentiation.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Surgery, Albany Medical College, Albany, NY 12208; Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208. Electronic address:

Following cutaneous injury, keratinocytes secrete paracrine factors that regulate wound cell functions; dysregulation of this signaling can lead to wound pathologies. Previously, we established that keratinocyte integrin α3β1 promotes wound angiogenesis through paracrine stimulation of endothelial cells. We hypothesize here that α3β1-dependent paracrine signaling from keratinocytes regulates the differentiation state of myofibroblasts. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.025DOI Listing

Cis-khellactone inhibited the proinflammatory macrophages via promoting autophagy to ameliorate imiquimod-induced psoriasis.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

State Key Laboratory of Pharmaceutical Biotechnology, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. Electronic address:

Psoriasis is a chronic inflammatory skin disease with unresolved pathogenesis. Studies on the pathogenesis of psoriasis have been extensively carried out, but treatments are still not satisfactory. In this study, we found improvement after treatment with cis-khellactone, a small molecular natural product, in imiquimod (IMQ)-challenged C57BL/6 mice. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.021DOI Listing
March 2019
1 Read
7.216 Impact Factor

Loss of epidermal hypoxia-inducible factor-1α blocks UVB-induced tumorigenesis by affecting DNA repair capacity and oxidative stress.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Univ. Bordeaux, Inserm, BMGIC, U1035, F-33000 Bordeaux, France; Centre de Référence pour les Maladies Rares de la Peau, CHU de Bordeaux, France. Electronic address:

Hypoxia-inducible factor-1α (HIF-1α) is constitutively expressed in mouse and human epidermis. It plays a crucial role in skin physiology including the response of keratinocytes to ultraviolet (UV) radiation. However, little information is available about its role in photocarcinogenesis. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.035DOI Listing
March 2019
1 Read
7.216 Impact Factor

Bone morphogenetic protein-6 inhibits fibrogenesis in scleroderma offering new treatment options of fibrotic skin disease.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Institute of Biochemistry, Emil-Fischer-Center, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany; Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen, Germany. Electronic address:

Bone morphogenetic protein-6 (BMP6) is known to be crucial for regulating embryonic skin development. This study assessed the role of BMP6 in dermal fibrosis. We detected that BMP6 is significantly increased in skin-derived fibroblasts of patients with localized scleroderma. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.020DOI Listing

HLA-C*01:02 and HLA-A*02:07 Confer Risk Specific for Psoriatic Patients in southern China.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Institute of Dermatology, Anhui Medical University, Hefei, China; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China; State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, China; Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193132
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http://dx.doi.org/10.1016/j.jid.2019.02.027DOI Listing
March 2019
4 Reads

Racial/Ethnic Variation in Use of Ambulatory and Emergency Care for Atopic Dermatitis Among U.S. Children.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

Previous studies indicate racial/ethnic differences in healthcare utilization for pediatric atopic dermatitis (AD) but do not account for disease severity impact. We sought to examine the relationship between race/ethnicity and healthcare utilization, both overall and by specific visit type, while accounting for AD control. A longitudinal cohort study of children with AD in the U. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.024DOI Listing

Peptidylarginine Deiminase Inhibitor Cl-amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

UDEAR, Institut National de la Santé Et de la Recherche Médicale, Université de Toulouse Midi-Pyrénées, Toulouse, France. Electronic address:

Deimination, a post-translational modification catalyzed by a family of enzymes called peptidylarginine deiminases (PADs), is the conversion of arginine into citrulline residues in a protein. Deimination has been associated with numerous physiological and pathological processes. Our aim was to study its implication in the homeostasis of human epidermis, where three PADs are expressed, namely PAD1, 2 and 3. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.026DOI Listing
March 2019
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Chronic UVA1 irradiation of human dermal fibroblasts: persistence of DNA damage and validation of a cell-cultured based model of photoaging.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Centre de Recherche du CHU de Québec - Université Laval, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, Canada; Université Laval, Faculté de Médecine, Département d'Ophtalmologie, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.022DOI Listing

Amphiregulin from basophils amplifies basophil-mediated chronic skin inflammation.

J Invest Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jid.2019.02.023DOI Listing

Demographics and Autoantibody Profiles of Pemphigoid Patients with Underlying Neurologic Diseases.

J Invest Dermatol 2019 Mar 12. Epub 2019 Mar 12.

The University of Iowa, Department of Dermatology, Iowa City, IA, USA; Iowa City VA Medical Center, Iowa City, IA, USA. Electronic address:

Bullous pemphigoid (BP) is an autoantibody-mediated blistering disease that is often associated with neurologic disease. BP antibodies target two epidermal adhesion molecules, known as BP180 and BP230. Homologues to these proteins are found in the brain, and it is hypothesized that neurologic disease leads to the production of autoantibodies that can cross react with their cutaneous forms. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.034DOI Listing
March 2019
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Response to the commentary "Ambiguous role of SATB1 expression in malignant tumors".

J Invest Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Dermatology and Venereology, Peking University First Hospital, Beijing 100034, China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing 100034, China. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.01.032DOI Listing

Preclinical Targeting of MicroRNA-214 in Cutaneous T-cell Lymphoma (CTCL).

J Invest Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Comprehensive Cancer Center, Ohio State University, Columbus OH United States; Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Sidney Kimmel Cancer Center, Philadelphia, PA; Division of Dermatology, Department of Internal Medicine, Ohio State University, Columbus OH United States. Electronic address:

Cutaneous T-cell lymphomas (CTCL) are a family of primary extranodal lymphomas of mature CD4+, skin-homing or skin-resident T-cells. In a significant fraction of CTCL patients the neoplastic CD4+ lymphocytes acquire extracutaneous tropism, and with disease progression, they disseminate to the lymph nodes, peripheral blood, and visceral organs. MicroRNA (miR)-based therapies are a newly emerging strategy for many types of diseases, including cancers. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.033DOI Listing
March 2019
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