19,398 results match your criteria Journal of Investigative Dermatology[Journal]


Hyperglycemia is associated with psoriatic inflammation in both humans and mice.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. Electronic address:

Chronic low-grade inflammation can cause several metabolic syndromes. Patients with psoriasis, a chronic immunological skin inflammation, often develop diabetes. However, it is not clear to date how psoriasis leads to, or is correlated with, glucose intolerance. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.029DOI Listing
February 2019

Nicotinamide Metabolism Modulates the Proliferation / Differentiation Balance and Senescence of Human Primary Keratinocytes.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Cell Cycle Control in Skin Epidermis, Skin Research Institute of Singapore, A*STAR, 8A Biomedical Grove, Singapore 138648; School of Biological Sciences & Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 637551. Electronic address:

Nicotinamide (NAM) is the main precursor of NAD, a co-enzyme essential for DNA repair, glycolysis and oxidative phosphorylation (OXPHOS). NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3D organotypic skin models, we show that NAM inhibits differentiation of the upper epidermal layers and maintains proliferation in the basal layer. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.005DOI Listing
February 2019

Dynamic evolution of clonal composition and neoantigen landscape in recurrent metastatic melanoma with a rare combination of driver mutations.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR7104 CNRS; U1258 INSERM; Université de Strasbourg, Department of Functional Genomics and Cancer, 1 Rue Laurent Fries, 67404 Illkirch Cédex. France. Electronic address:

In melanoma, initiating oncogenic mutations in BRAF or NRAS are detected in premalignant lesions that accumulate additional mutations and genomic instability as the tumour evolves to the metastatic state. Here we investigate evolution of clonal composition and neoantigen landscape in an atypical melanoma displaying recurrent cutaneous lesions over a 6-year period without development of extra-cutaneous metastases. Whole exome sequencing of 4 cutaneous lesions taken over the 6-year period identified a collection of single nucleotide variants (SNVs) and small insertions and deletions (Indels) shared amongst all tumours along with progressive selection of subclones displaying fewer SNVs. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.027DOI Listing
February 2019

SOX2 epidermal overexpression promotes cutaneous wound healing via activation of EGFR/MEK/ERK signaling mediated by EGFR ligands.

J Invest Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Skin Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA. Electronic address:

Oral mucosa contains a unique transcriptional network that primes oral wounds for rapid resolution in humans. Our previous work identified genes that were consistently upregulated in the oral mucosa and demonstrated that induction of one of the identified genes, transcription factor SOX2, promoted cutaneous wound healing in mice. In this study, we investigated the molecular and cellular mechanisms by which SOX2 accelerates wound healing in skin. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.004DOI Listing
February 2019

Molecular genomic profiling of melanocytic nevi.

J Invest Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Melanoma Institute Australia, The University of Sydney, NSW, Australia; Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

The benign melanocytic nevus is the commonest tumor in humans and rarely transforms into cutaneous melanoma. Elucidation of the nevus genome is required to better understand the molecular steps of progression to melanoma. We performed whole genome sequencing on a series of 14 benign melanocytic nevi, consisting of both congenital and acquired types. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193011
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http://dx.doi.org/10.1016/j.jid.2018.12.033DOI Listing
February 2019
5 Reads

Differential hairless mouse strain-specific susceptibility to skin cancer and sunburn.

J Invest Dermatol 2019 Feb 8. Epub 2019 Feb 8.

The Jackson Laboratory, Mammalian Genomics, Bar Harbor, ME, USA.

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http://dx.doi.org/10.1016/j.jid.2019.01.028DOI Listing
February 2019
1 Read

The NLRP1 inflammasome pathway is silenced in cutaneous squamous cell carcinoma.

J Invest Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, 8006 Zurich, Switzerland. Electronic address:

The inflammasome protein NLRP1 is an important innate immune sensor in human keratinocytes and mediates, together with the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1, the activation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. These cytokines and inflammasomes can have in part opposing roles during tumorigenesis in mice. In contrast, ASC expression is impaired in different types of cancer in humans. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.025DOI Listing
February 2019
3 Reads

Fibulin-3 has anti-tumorigenic activities in cutaneous squamous cell carcinoma.

J Invest Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancers. Several previous studies have shown that Fibulin-3 participates in the occurrence and development of various tumors; however, its role in cSCC remains unknown. In the present study, we observed that the expression of Fibulin-3 was down-regulated in cSCC tissues compared with normal skin tissues, which was due to Fibulin-3 promoter methylation. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.022DOI Listing
February 2019
1 Read

IL-17E (IL-25) enhances innate immune responses during skin inflammation.

J Invest Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address:

IL-17E (IL-25) is a member of the IL-17 cytokine family involved in the promotion of type 2 immune responses. Recently, IL-17E has been reported to be upregulated in distinct skin inflammatory diseases such as psoriasis, atopic and contact dermatitis. We assessed the role played by IL-17E in skin inflammation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193010
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http://dx.doi.org/10.1016/j.jid.2019.01.021DOI Listing
February 2019
1 Read

Racial Differences in Perceptions of Psoriasis Therapies: Implications for Racial Disparities in Psoriasis Treatment.

J Invest Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Biostatistics, Epidemiology and Informatics, Perelman School Medicine School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Center for Clinical Epidemiology and Biostatistics, Perelman School Medicine School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Family Medicine and Community Health, Perelman School Medicine School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

In the U.S., black patients are less likely than whites to receive biologic treatment for their psoriasis. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.032DOI Listing
February 2019

Zinc-alpha-2 glycoprotein regulates the skin barrier and immunity in atopic dermatitis.

J Invest Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Adipokines modulate immune responses and lipid metabolism in allergic disease; however, little is known about its role in the skin barrier and atopic dermatitis (AD). We identified zinc-alpha-2 glycoprotein (ZAG), an adipokine that regulates lipid mobilization, as a biomarker for AD. ZAG levels were consistently decreased in sera, T cells, and skin in human AD patients compared with healthy controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193010
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http://dx.doi.org/10.1016/j.jid.2019.01.023DOI Listing
February 2019
3 Reads

Increased type 2 innate lymphoid cells in patients with drug reaction with eosinophilia and systemic symptom.

J Invest Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Drug reaction with eosinophilia and systemic symptom (DRESS) is life-threatening disorder with an estimated mortality of 2%. Recently, type II innate lymphoid cells (ILC2s) has been implicated as an important contributor to the pathogenesis of allergic disorders. However, whether the roles of ILC2s and ILC2-associated cytokines in DRESS remain unclear. Read More

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http://dx.doi.org/10.1016/j.jid.2018.10.048DOI Listing
February 2019
1 Read
7.216 Impact Factor

Genomic heterogeneity and branched evolution of early-stage primary acral melanoma revealed by multi-regional microdissection sequencing.

J Invest Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Beijing Advanced Innovation Center for Genomics (ICG), Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, College of Engineering, Peking-Tsinghua Center for Life Sciences, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and Department of Dermatology, First Hospital, Peking University, Beijing, China. Electronic address:

Acral melanoma (AM) is an extremely aggressive subtype of melanoma that is prevalent in east Asia. AM exhibits high intertumoral and intratumoral heterogeneities with poor prognosis. To associate the genomic heterogeneities with phenotypic traits and efficacy of treatments, a method is needed to recover genomic information from limited samples with high specificity and sensitivity from early stage AM specimens. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193004
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http://dx.doi.org/10.1016/j.jid.2019.01.019DOI Listing
January 2019
1 Read

Epigenetic regulation of iASPP-p63 feedback loop in cutaneous squamous cell carcinoma.

J Invest Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, London E1 2AT, UK. Electronic address:

Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the UK. P53 is frequently mutated in cSCC. iASPP is a key inhibitor of p53 and NF-kB signalling pathways and has been documented as highly expressed in several types of human cancer. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.020DOI Listing
January 2019
1 Read

Morpholino-Mediated Gene knockdown in Zebrafish: It's All About Dosage and Validation.

J Invest Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Center for Medical Genetics, Ghent University Hospital, Belgium; Department of Biomolecular Medicine, Ghent University, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.01.017DOI Listing
January 2019

Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma.

J Invest Dermatol 2019 Jan 29. Epub 2019 Jan 29.

Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford CA, United States of America. Electronic address:

Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naïve tumors responsiveness to Smoothened inhibitors (Smo), resistance in advanced tumors remains frequent. While the resistant BCCs usually maintain HH pathway activation, squamous cell carcinomas with Ras/MAPK pathway activation also arise, with the molecular basis of tumor type and pathway selection still obscure. Read More

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http://dx.doi.org/10.1016/j.jid.2018.11.035DOI Listing
January 2019

BET inhibition modifies melanoma infiltrating T cells and enhances response to PD-L1 blockade.

J Invest Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Dermatology & Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Sidney Kimmel Cancer Center at Jefferson, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193002
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http://dx.doi.org/10.1016/j.jid.2018.12.024DOI Listing
January 2019
2 Reads

Chronic inflammation in response to injury: retention of myeloid cells in injured tissue is driven by myeloid cell-intrinsic factors.

J Invest Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, United Kingdom. Electronic address:

Chronic inflammation is a hallmark of impaired healing in a plethora of tissues, including skin, and is associated with aging and diseases such as diabetes. Diabetic chronic skin wounds are characterized by excessive myeloid cells that display an aberrant phenotype, partially mediated by stable intrinsic changes induced during hematopoietic development. However, the relative contribution of myeloid cell-intrinsic factors to chronic inflammation versus aberrant signals from the local environmental was unknown. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.030DOI Listing
January 2019
1 Read

Itraconazole induces regression of infantile hemangioma via down-regulation of the PDGF-D/PI3K/Akt/mTOR pathway.

J Invest Dermatol 2019 Jan 25. Epub 2019 Jan 25.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address:

Infantile hemangioma (IH) is the most common benign vascular tumor of infancy. We have previously reported that itraconazole, a common anti-fungal agent, can clinically improve or cure IH; however, the underlying molecular mechanisms are still unclear. Here, we show that itraconazole treatment significantly inhibits the proliferation and promotes apoptosis of the endothelial cells of mouse hemangioma (EOMA) cell line and infantile primary hemangioma endothelial cell (HemEC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193003
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http://dx.doi.org/10.1016/j.jid.2018.12.028DOI Listing
January 2019
6 Reads

MicroRNAs in Cutaneous T-Cell Lymphoma: The Future of Therapy.

J Invest Dermatol 2019 Jan 24. Epub 2019 Jan 24.

Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA; Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio USA; Department of Medical Oncology, Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

MicroRNAs (miRs) are small, noncoding RNAs with numerous cellular functions. With advancing knowledge of the many functions of miRs in cancer pathogenesis, there is emerging interest in miRs as therapeutic targets in cancers. One disease that poses an intriguing model for miR therapy is cutaneous T-cell lymphoma, a rare disease featuring malignant CD4 T cells that proliferate in the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183281
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http://dx.doi.org/10.1016/j.jid.2018.10.035DOI Listing
January 2019
3 Reads

Analysis of the tumor reactivity of tumor-infiltrating lymphocytes in a metastatic melanoma lesion that lost MHC class I expression after anti-PD-1 therapy.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Dermatology, University of Yamanashi, Japan.

MHC class I loss due to the abnormality of β2-microgloburin (B2M) gene is one of the mechanism underlying delayed relapses in melanoma patients long after the initial positive responses to anti-PD-1 therapy. However, the tumor-specific reactivity of tumor-infiltrating lymphocytes (TILs) in tumor lesions that lost MHC class I expression has not been well evaluated. We report the case of a 55-year-old woman with two metastatic melanoma lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193002
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http://dx.doi.org/10.1016/j.jid.2019.01.007DOI Listing
January 2019
5 Reads

Meeting report - Skin Inflammation in Human Health and Disease: 2018 International Conference.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Brigham and Women's Hospital, Department of Dermatology and Human Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.jid.2019.01.009DOI Listing
January 2019
1 Read

A polymorphic variant in p19 confers resistance to chemically-induced skin tumors by activating the p53 pathway.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, 666-2 Nitonacho Chuouku, Chiba 260-8717, Japan. Electronic address:

Identification of the specific genetic variants responsible for the increased susceptibility to familial or sporadic cancers is important. Using a forward genetics approach to map such loci in a mouse skin cancer model, we previously identified a strong genetic locus, Stmm3 (skin tumor modifier of MSM 3), conferring resistance to chemically-induced skin papillomas on chromosome 4. Here, we report the cyclin-dependent kinase inhibitor gene Cdkn2a/p19 as a major responsible gene for the Stmm3 locus. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.027DOI Listing
January 2019
1 Read

Thrombospondin-1 is a major activator of TGF-beta signaling in recessive dystrophic epidermolysis bullosa fibroblasts.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Dermatology & Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Mutations in the gene encoding collagen VII (C7) cause the devastating blistering disease recessive dystrophic epidermolysis bullosa (RDEB). RDEB is characterized by severe skin fragility and non-healing wounds aggravated by scarring and fibrosis. We previously demonstrated that thrombospondin-1 (TSP1) is increased in RDEB fibroblasts. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.011DOI Listing
January 2019
2 Reads

Imiquimod-induced psoriasis in mice depends on the IL-17 signaling of keratinocytes.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Department of Dermatology, Heidelberg University Hospital, 69120 Heidelberg, Germany. Electronic address:

Pathology of psoriasis strongly depends on IL-17A. Monoclonal antibodies blocking either the cytokine or its receptor are amongst the most efficient treatments for psoriatic patients. Keratinocytes can be activated upon exposure to IL-17A and TNFα and secrete secondary cytokines and chemokines in the inflamed skin. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.006DOI Listing
January 2019
1 Read

Exposure to solar ultraviolet radiation suppresses cell-mediated immunisation responses in humans: the Australian Ultraviolet Radiation and Immunity Study.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

National Centre for Epidemiology and Population Health, Research School of Population Health, The Australian National University, Australia; Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia. Electronic address:

Animal and human studies show that exposure to solar-simulated ultraviolet radiation (UVR) is immunomodulatory. Human studies using natural sun exposure and controlling for confounding are rare. We immunised 217 healthy adults (18-40 years) with a T-cell dependent antigen, keyhole limpet haemocyanin (KLH) and measured personal clothing-adjusted UVR (ca-UVR) exposure (for five days before and after immunisation), lifetime cumulative UVR exposure, serum 25-hydroxyvitamin D (25(OH)D) concentration at immunisation, and potential confounding factors. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.025DOI Listing
January 2019
2 Reads

Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, The University of Hull, HU6 7RX, United Kingdom. Electronic address:

Cellular senescence can be broadly defined as a stable, yet essentially irreversible, loss of proliferative capacity. Historically, senescence is described as a negative outcome of advanced cellular age. It is now clear, however, that senescence represents a dynamic autonomous stress response, integral to long-term tumour suppression. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.005DOI Listing
January 2019
2 Reads

Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Sydney, Australia; Children's Cancer Institute, Kensington, Australia; St Vincent's Clinical School, UNSW Sydney, Sydney, Australia.

Cutaneous squamous cell carcinoma (cSCC) from the head and neck typically metastasizes to the lymph nodes of the neck and parotid glands. When a primary is not identified, they are difficult to distinguish from metastases of mucosal origin and primary salivary gland SCC. Ultraviolet radiation causes a mutation pattern that predominantly features cytosine to thymine transitions at dipyrimidine sites and has been associated with cSCC. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.008DOI Listing
January 2019

Yin-yang of IL-33 in human skin mast cells: reduced degranulation, but augmented histamine synthesis through p38 activation.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Dermatology and Allergy, Charité Campus Mitte, Germany.

Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their pronounced receptor expression, MCs are important targets of IL-33 action, but consequences for skin MCs are ill-defined, especially upparon chronic exposure to IL-33. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.013DOI Listing
January 2019
2 Reads

Topical application of a dual ABC transporter substrate and NF-κB inhibitor blocks multiple sources of cutaneous inflammation in mouse skin.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892, USA. Electronic address:

Among the molecular signals underlying cutaneous inflammation is the transcription complex NF-κB, its upstream modulators, and cytokines and chemokines that are the downstream pro-inflammatory effectors. Central to NF-κB activation is I kappa B kinase (IKK) that phosphorylates IκBα releasing NF-κB to the nucleus. In a screen of a kinase inhibitor library, we identified two IKK inhibitors that were high affinity substrates for Pgp (p-glycoprotein, ABCB1), the multidrug resistance protein known to facilitate transdermal drug delivery. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.026DOI Listing
January 2019
1 Read

IL-17 and IL-22 promote keratinocyte stemness in the germinative compartment in psoriasis.

J Invest Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Ingrid Asp Psoriasis Research Center, Department of Clinical and Experimental Medicine, Division of Dermatology, Linköping University, Linköping, Sweden. Electronic address:

Psoriasis is an inflammatory skin disorder characterized by the hyperproliferation of basal epidermal cells. It is regarded as T-cell mediated, but the role of keratinocytes (KCs) in the disease pathogenesis has reemerged with genetic studies identifying KC-associated genes. We applied flow cytometry on KCs from lesional and non-lesional epidermis to characterize the phenotype in the germinative compartment in psoriasis and observed an overall increase in the stemness markers CD29 (2. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.014DOI Listing
January 2019
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Acute ethanol exposure augments low dose UVB-mediated systemic immunosuppression via enhanced production of Platelet-activating factor receptor agonists.

J Invest Dermatol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pharmacology and Toxicology, Boonshoft School of Medicine at Wright State University, Dayton, OH 45435.

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http://dx.doi.org/10.1016/j.jid.2018.11.034DOI Listing
January 2019
7.216 Impact Factor

Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts.

J Invest Dermatol 2019 Jan 19. Epub 2019 Jan 19.

Department of Clinical Laboratory and Molecular Pathology, Graduate School of Medical and Pharmaceutical Science, University of Toyama, Toyama, Japan. Electronic address:

Atopic dermatitis is a chronic inflammatory skin disease with persistent pruritus. To clarify its molecular mechanism, it is important to establish a mouse model similar to the phenotypes of atopic dermatitis patients, particularly in exhibiting scratching behavior. Ikk2, a component of the IκB kinase complex, exerts pro-inflammatory responses, whereas its deficiency in keratinocytes paradoxically causes skin inflammation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183292
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http://dx.doi.org/10.1016/j.jid.2018.10.047DOI Listing
January 2019
2 Reads

Montagna Symposium 2017-Profiling Immune Expression to Consider Repurposing Therapeutics for the Ichthyoses.

Authors:
Amy S Paller

J Invest Dermatol 2019 Jan 19. Epub 2019 Jan 19.

Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:

Despite extensive discovery about the mutations underlying genetic skin disorders, there have been few therapeutic advances. Better understanding of the molecular changes that may lead to the phenotypic manifestations of genetic disorders may lead to the discovery of new pharmacologic interventions. The ichthyoses are characterized by scaling, inflammation, and an impaired epidermal barrier. Read More

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http://dx.doi.org/10.1016/j.jid.2018.08.027DOI Listing
January 2019
1 Read

Cells to Surgery Quiz: February 2019.

J Invest Dermatol 2019 Feb;139(2):e17-e21

Department of Dermatology, University of Texas Southwestern, Dallas, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.12.008DOI Listing
February 2019

SnapshotDx Quiz: February 2019.

J Invest Dermatol 2019 Feb;139(2):e11-e15

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.12.011DOI Listing
February 2019

Corrigendum.

Authors:

J Invest Dermatol 2019 Feb;139(2):496-497

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http://dx.doi.org/10.1016/j.jid.2018.11.014DOI Listing
February 2019

Corrigendum.

Authors:

J Invest Dermatol 2019 Feb;139(2):495-496

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http://dx.doi.org/10.1016/j.jid.2018.11.013DOI Listing
February 2019

Corrigendum.

Authors:

J Invest Dermatol 2019 Feb;139(2):495

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http://dx.doi.org/10.1016/j.jid.2018.11.015DOI Listing
February 2019

Zika Virus Infection RIG-ged by Keratinocytes and Fibroblasts.

J Invest Dermatol 2019 Feb;139(2):281-282

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada; Division of Dermatology, Women's College Hospital, Toronto, Canada. Electronic address:

Zika virus is an emergent virus targeting the skin. Ji-Ae et al. (2018) explore the interactions between Zika virus and skin cells. Read More

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http://dx.doi.org/10.1016/j.jid.2018.09.003DOI Listing
February 2019

Research Techniques Made Simple: Itch Measurement in Clinical Trials.

J Invest Dermatol 2019 Feb;139(2):264-269.e1

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA; Center for the Study of Itch, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address:

Chronic itch, defined as itch lasting longer than 6 weeks, is a highly prevalent and debilitating symptom known to profoundly and negatively affect quality of life. The development of effective targeted therapies for some chronic itch disorders such as atopic dermatitis has given widespread recognition to the importance of measuring itch in clinical trials. Clinical trials now use itch measurement as a primary outcome measure, and steps toward the standardization of itch assessment are being made to meet the growing need for reliably measuring itch and its impact on quality of life in the clinical research setting. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.004DOI Listing
February 2019

Ambiguous role of SATB1 expression in malignant tumors.

J Invest Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

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http://dx.doi.org/10.1016/j.jid.2019.01.001DOI Listing
January 2019

Growth hormone operates as a neuroendocrine regulator of human hair growth ex vivo.

J Invest Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Centre for Dermatology Research, University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester, UK; Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.12.022DOI Listing
January 2019

The Actin-Based Motor Myosin Vb is Crucial to Maintain the Epidermal Barrier Integrity.

J Invest Dermatol 2019 Jan 17. Epub 2019 Jan 17.

UDEAR, UMR 1056 Institut National de la Santé et de la Recherche Médicale, University of Toulouse, Toulouse, France. Electronic address:

Myosin Vb (Myo5b) is an unconventional myosin involved in the actin-dependent transport and tethering of intracellular organelles. In the epidermis, granular keratinocytes accumulate cytoplasmic lamellar bodies (LB), secretory vesicles released at the junction with the stratum corneum which participate actively in the maintenance of the epidermal barrier. We have previously demonstrated that LB biogenesis is controlled by the Rab11a GTPase, known for its ability to recruit the Myo5b motor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193001
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http://dx.doi.org/10.1016/j.jid.2018.12.021DOI Listing
January 2019
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Reply to van Gils and Vanakker.

J Invest Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology and Cutaneous Biology, and the Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193001
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http://dx.doi.org/10.1016/j.jid.2019.01.003DOI Listing
January 2019
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Dsg1 deficiency causes lethal skin blistering.

J Invest Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Ludwig-Maximilians-Universität (LMU) Munich, Institute of Anatomy and Cell Biology, Department I, Pettenkoferstrasse 11, D-80336 Munich / Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.01.002DOI Listing
January 2019
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The EGR1-STAT3 Transcription Factor Axis Regulates α-MSH-induced Tyrosinase Gene Transcription in Melanocytes.

J Invest Dermatol 2019 Jan 12. Epub 2019 Jan 12.

Department of Biological Sciences, Sanghuh College of Life Sciences, Konkuk University, Seoul, Republic of Korea; Cancer and Metabolism Institute, Konkuk University, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.12.020DOI Listing
January 2019

Mechanical stretch exacerbates psoriasis by stimulating keratinocyte proliferation and cytokine production.

J Invest Dermatol 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Psoriasis is a chronic inflammatory autoimmune skin disease that often occurs in rubbed areas undergoing a strong mechanical stretch, such as the elbows and knees. However, the pathologic role of mechanical tension in psoriasis remains unclear. In this study, we investigated the contribution of keratinocyte mechanical stretch to the clinical features of psoriasis. Read More

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http://dx.doi.org/10.1016/j.jid.2018.12.019DOI Listing
January 2019