186,888 results match your criteria Journal of Interferon & Cytokine Research[Journal]


Screening of novel drugs for inhibiting hepatitis E virus replication.

J Virol Methods 2019 Apr 17. Epub 2019 Apr 17.

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi 329-0498, Japan. Electronic address:

Hepatitis E, which is caused by hepatitis E virus (HEV), is generally a self-limiting, acute, and rarely fatal disease. It is sometimes fulminant and lethal, especially during pregnancy. Indeed, it occasionally takes a chronic course in immunocompromised individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934183029
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http://dx.doi.org/10.1016/j.jviromet.2019.04.017DOI Listing
April 2019
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Plasmacytoid Dendritic Cells and Infected Cells Form an Interferogenic Synapse Required for Antiviral Responses.

Cell Host Microbe 2019 Apr 15. Epub 2019 Apr 15.

CIRI, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, Lyon F-69007, France. Electronic address:

Type I interferon (IFN-I) is critical for antiviral defense, and plasmacytoid dendritic cells (pDCs) are a predominant source of IFN-I during virus infection. pDC-mediated antiviral responses are stimulated upon physical contact with infected cells, during which immunostimulatory viral RNA is transferred to pDCs, leading to IFN production via the nucleic acid sensor TLR7. Using dengue, hepatitis C, and Zika viruses, we demonstrate that the contact site of pDCs with infected cells is a specialized platform we term the interferogenic synapse, which enables viral RNA transfer and antiviral responses. Read More

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http://dx.doi.org/10.1016/j.chom.2019.03.005DOI Listing

Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.

Cytokine 2019 Apr 16;120:28-40. Epub 2019 Apr 16.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. Electronic address:

Viperin is an interferon-inducible protein that helps in protecting mammals against various virus infections. Viperin is a highly conserved member of the interferon-stimulated genes (ISG) family in many species. Viperin has been shown to play a pivotal role in the innate immunity of chicken; however, its role has not been explored in its antiviral potential. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.007DOI Listing

Black carp TAB1 up-regulates TAK1/IRF7/IFN signaling during the antiviral innate immune activation.

Fish Shellfish Immunol 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, 410081, China. Electronic address:

TAK1-binding protein 1 (TAB1) forms the protein complex with TAK1 and enhances its kinase activity in human and mammals. To elucidate the role of TAB1 in the innate immunity of teleost sfih, the TAB1 homologue of black carp (Mylopharyngodon piceus) (bcTAB1) has been cloned and characterized in this paper. bcTAB1 is composed of 498 amino acids and contains a typical PP2Cc domain like its mammalian counterpart. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193027
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http://dx.doi.org/10.1016/j.fsi.2019.04.040DOI Listing
April 2019
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The Effect of Race Training on the Basal Gene Expression of Alveolar Macrophages Derived From Standardbred Racehorses.

J Equine Vet Sci 2019 Apr 29;75:48-54. Epub 2019 Jan 29.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.

Mild-to-moderate equine asthma is prevalent in young racehorses, particularly early in their training period. Although the precise etiopathogenesis remains undetermined, it is possible that the susceptibility of this population might partly reflect an exercise-associated immune derangement at the level of the airway. We performed a genome-wide basal gene expression scan on alveolar macrophages (AMs) isolated from Standardbred racehorses before and after commencement of competition race training with a view to identifying any exercise-associated gene expression modulation consistent with functional alterations, which might reflect training-associated immunological derangement. Read More

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http://dx.doi.org/10.1016/j.jevs.2019.01.010DOI Listing

Assessment of the structural reorganization of liver and biochemical parameters of blood serum after introduction of zinc nanoparticles and its oxides.

Environ Sci Pollut Res Int 2019 Apr 18. Epub 2019 Apr 18.

Federal Research Centre of Biological Systems and Agro-Technologies of the Russian Academy of Sciences, Orenburg State University, Orenburg, Russia.

The demand for nanoparticles of metals and their oxides in medicine and biology is indisputable. To ensure the safe use of the unique capabilities of nanostructures, in particular, essential metals and their oxides, and to further search for ways leveling side effects of toxic effects in biomedical applications, a multifaceted approach to the study of their properties is needed, primarily affecting the effects on the organism level. In this connection, the purpose of the present research was to study the effect of zinc nanoparticles (ZnNPs) and zinc oxide nanoparticles (ZnONPs) on structural reorganization of the liver and morpho-biochemical parameters of rat blood. Read More

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http://dx.doi.org/10.1007/s11356-019-05128-8DOI Listing

Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice.

Purinergic Signal 2019 Apr 18. Epub 2019 Apr 18.

School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, 2522, Australia.

Graft-versus-host disease (GVHD) is a life-threatening consequence of allogeneic haematopoietic stem cell transplantation, a curative therapy for haematological malignancies. The ATP-gated P2X7 receptor channel is implicated in the development of GVHD. P2X7 activity on human leukocytes can be influenced by gain-of-function (GOF) and loss-of-function (LOF) single nucleotide polymorphisms (SNPs) in the P2RX7 gene. Read More

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http://dx.doi.org/10.1007/s11302-019-09651-8DOI Listing

Safety and Efficacy of Sofosbuvir with Ribavirin® in Hepatitis C, Genotype 3 Patients with Cirrhosis: A Real-world Experience.

Cureus 2019 Feb 4;11(2):e4012. Epub 2019 Feb 4.

Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction Hepatitis C virus (HCV) is the leading cause of cirrhosis. The advent of Directly Acting Antivirals (DAAs) like Sofosbuvir (SOF) has dramatized the treatment and is the cornerstone for the treatment of HCV. Most trials have been conducted in HCV genotype 1 (GT-1) and data for Interferon-free regimen in genotype 3 (GT-3) is limited especially in cirrhotic patients. Read More

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http://dx.doi.org/10.7759/cureus.4012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450597PMC
February 2019

The central role of nucleic acids in the pathogenesis of systemic lupus erythematosus.

Authors:
David S Pisetsky

F1000Res 2019 3;8. Epub 2019 Apr 3.

Department of Medicine and Immunology, Duke University Medical Center and Medical Research Service, VA Medical Center, Durham, NC, USA.

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease whose pathogenesis can be conceptualized by a model based on a central role for immune complexes (ICs) between antinuclear antibodies and nucleic acids. According to this model, ICs can promote pathogenesis by two main mechanisms: deposition in the tissue to incite local inflammation and interaction with cells of the innate immune system to stimulate the production of cytokines, most prominently type 1 interferon. The latter stimulation results from the uptake of DNA and RNA in the form of ICs into cells and subsequent signaling by internal nucleic acid sensors for DNA and RNA. Read More

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https://f1000research.com/articles/8-368/v1
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http://dx.doi.org/10.12688/f1000research.17959.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449788PMC
April 2019
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Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells.

Evid Based Complement Alternat Med 2019 14;2019:6797030. Epub 2019 Mar 14.

Department of Life Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.

is a traditional Chinese medicine widely used for treating diarrhea, ulceration, and enuresis. Moreover, is effective for cognitive function improvement and nerve regeneration. Multiple sclerosis (MS) is a chronic neuronal inflammatory autoimmune disease that commonly affects young adults in high-latitude regions. Read More

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https://www.hindawi.com/journals/ecam/2019/6797030/
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http://dx.doi.org/10.1155/2019/6797030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437745PMC
March 2019
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Activated Mesenchymal Stromal Cells Process and Present Antigens Regulating Adaptive Immunity.

Front Immunol 2019 3;10:694. Epub 2019 Apr 3.

Department of Diabetes Immunology, Diabetes and Metabolism Research Institute at the Beckman Research Institute of City of Hope, Duarte, CA, United States.

Mesenchymal stromal cells (MSCs) are inherently immunomodulatory through production of inhibiting soluble factors and expression of immunosuppressive cell surface markers. We tested whether activated MSCs qualify for the induction of antigen-specific immune regulation. Bone marrow derived human MSCs were activated by interferon-γ and analyzed for antigen uptake and processing and immune regulatory features including phenotype, immunosuppressive capacity, and metabolic activity. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00694
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http://dx.doi.org/10.3389/fimmu.2019.00694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457321PMC
April 2019
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Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing .

Front Immunol 2019 2;10:578. Epub 2019 Apr 2.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

and both contain risk alleles for systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our group predicts specific endolysosomal-dependent immune responses are driven by the protein products of these genes, which form a complex at the endolysosomal surface. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00578
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http://dx.doi.org/10.3389/fimmu.2019.00578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454867PMC
April 2019
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Tuberculosis in Pregnancy - a Summary.

Geburtshilfe Frauenheilkd 2019 Apr 8;79(4):358-365. Epub 2019 Jan 8.

Abteilung für Geburtsmedizin, Universitätsfrauenklinik Leipzig, Universitätsklinikum Leipzig AöR, Leipzig, Germany.

In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculosis cases among pregnant women can be assumed due to the migratory flows; current data from the USA, for example, also show an increasing incidence of tuberculosis in pregnant women in recent years. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0774-7924
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http://dx.doi.org/10.1055/a-0774-7924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461468PMC
April 2019
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Raised levels of IFN-gamma and IL-13 are associated with pre-diabetes amongst newly diagnosed patients with Tuberculosis.

J Pak Med Assoc 2019 Apr;69(4):468-473

Indus Hospital, Karachi.

Objective: To investigate pre-diabetes and diabetes in newly-diagnosed tuberculosis patients and to assess the association of serum cytokine levels with diabetes status.

Methods: The cross-sectional study was conducted at Indus Hospital and The Aga Khan University Hospital, Karachi from May to November 2015, and included patients of either gender aged 18 years or more with a confirmed diagnosis of tuberculosis who were either newly diagnosed or had received up to 1 month of anti-tuberculosis therapy were included. Patients were enrolled from among those presenting to the clinics at Indus Hospital, Karachi, and the Department of Medicine, Aga Khan University Hospital (AKUH), Karachi. Read More

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April 2019
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Dual mechanism of action of T2 inhibitor therapies in virally induced exacerbations of asthma: evidence for a beneficial counter-regulation.

Eur Respir J 2019 Apr 18. Epub 2019 Apr 18.

Professor of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, UK.

Biological agents such as omalizumab and monoclonal antibodies that inhibit type 2 immunity significantly reduce exacerbations, which are mainly due to viral infections, when added to inhaled corticosteroids in patients with severe asthma. The mechanisms for the therapeutic benefit of type 2 inhibitors in reducing virally-induced exacerbations, however, remain to be fully elucidated. Preclinical and clinical evidence supports the existence of a close counter-regulation of the high-affinity IgE receptor and interferon pathways, and a potential dual mechanism of action and therapeutic benefit for omalizumab and other type 2 inhibitors that inhibit IgE activity, which may enhance the prevention and treatment of virally-induced asthma exacerbations. Read More

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http://dx.doi.org/10.1183/13993003.02390-2018DOI Listing

Dysregulation of humoral immunity in Foxp3 conditional-knockout mice.

Biochem Biophys Res Commun 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Pharmaceutical Immunology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. Electronic address:

Foxp3 regulatory T cells (Tregs) are crucial for maintaining tolerance to self-antigens and preventing autoimmune diseases. Loss of Foxp3 expression leads to autoimmunity and disrupts humoral immune responses, including hyperproduction of immunoglobulin E (IgE). Elucidation of how Tregs control antibody production can lead to the development of new therapies for autoimmune and allergic diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193073
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http://dx.doi.org/10.1016/j.bbrc.2019.04.090DOI Listing
April 2019
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PTEN-deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Cancer Biology and Genetics, Queen's Cancer Research Institute, Queen's University, Kingston, Canada.

Background: Accumulating evidence shows that tumor cell-specific genomic changes can influence the cross talk between cancer cells and the surrounding tumor microenvironment (TME). Loss of the PTEN tumor suppressor gene is observed in 20% to 30% of prostate cancers (PCa) when first detected and the rate increases with PCa progression and advanced disease. Recent findings implicate a role for PTEN in cellular type I interferon response and immunosuppression in PCa. Read More

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http://dx.doi.org/10.1002/pros.23808DOI Listing

Molecular cloning and mRNA expression of IFIT5 in tissues of ducklings infected with virulent duck hepatitis A virus type 3.

Res Vet Sci 2019 Apr 8;124:256-262. Epub 2019 Apr 8.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, Heilongjiang Province, PR China; Northeastern Science Inspection Station, China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of proteins strongly induced downstream of type I interferon signaling. The function of IFITs has been investigated extensively in mammals. IFIT5 is the sole protein in this family found in birds and little information is available about the function of avian IFIT5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183132
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http://dx.doi.org/10.1016/j.rvsc.2019.04.003DOI Listing
April 2019
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Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice.

Environ Int 2019 Apr 15;127:720-729. Epub 2019 Apr 15.

Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States of America. Electronic address:

Cadmium (Cd) is a toxic, pro-inflammatory metal ubiquitous in the diet that accumulates in body organs due to inefficient elimination. Responses to influenza virus infection are variable, particularly severity of pneumonia. We used a murine model of chronic low-dose oral exposure to Cd to test if increased lung tissue Cd worsened inflammation in response to sub-lethal H1N1 infection. Read More

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http://dx.doi.org/10.1016/j.envint.2019.03.054DOI Listing

Three novel compound heterozygous IL12RB1 mutations in Chinese patients with Mendelian susceptibility to mycobacterial disease.

PLoS One 2019 18;14(4):e0215648. Epub 2019 Apr 18.

Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Mendelian Susceptibility to Mycobacterial Diseases (MSMD) is a primary immunodeficiency disease (PID) characterized by variable susceptibility to weakly virulent mycobacteria (Bacille Calmette-Guerin, BCG) and various intramacrophagic bacteria, fungi, parasites. Mycobacterial disease generally begins in childhood, more rarely during adolescence and adulthood. The pathogenesis of MSMD is the inherited impaired production of interferon gamma (IFN-γ) or inadequate response to it. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215648PLOS
April 2019
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Meeting Overview: Interferon Lambda-Disease Impact and Therapeutic Potential.

J Interferon Cytokine Res 2019 Apr 17. Epub 2019 Apr 17.

4 Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

A meeting entitled, "Interferon Lambda: Disease Impact and Translational Potential," was held on the campus of the National Institutes of Health in Bethesda, Maryland, on October 25-26, 2018. To our knowledge, this was the first meeting that focused exclusively on interferon lambda (IFN-λ). The meeting's purpose was to enhance interdisciplinary communication and promote new collaborations. Read More

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https://www.liebertpub.com/doi/10.1089/jir.2019.0018
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http://dx.doi.org/10.1089/jir.2019.0018DOI Listing
April 2019
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MicroRNA-155: A Master Regulator of Inflammation.

J Interferon Cytokine Res 2019 Mar 20. Epub 2019 Mar 20.

Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

MicroRNAs (miRNAs) are naturally occurring, highly conserved families of transcripts (∼22 nucleotides in length) that are processed from larger hairpin precursors. miRNAs primarily regulate gene expression by promoting messenger RNA (mRNA) degradation or repressing mRNA translation. miRNAs have been shown to be important regulators of a variety of cellular processes involving development, differentiation, and signaling. Read More

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https://www.liebertpub.com/doi/10.1089/jir.2018.0155
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http://dx.doi.org/10.1089/jir.2018.0155DOI Listing
March 2019
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The Influence of Proinflammatory Cytokines on Voriconazole Trough Concentration in Patients With Different Forms of Hematologic Disorders.

J Clin Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Even though multiple factors are involved in the high fluctuation of voriconazole (VCZ) plasma concentration, little is known regarding the influence of proinflammatory cytokines on VCZ concentration. The aim of this study was to investigate the influence of proinflammatory cytokines, namely, interleukin (IL)-1β, IL-6, IL-18, interferon-γ, tumor necrosis factor-α, and transforming growth factor (TGF)-β1 on VCZ trough concentration (VCZ-C ) in Chinese patients with different forms of hematologic disorders. A total of 250 plasma samples from 113 patients were analyzed for VCZ-C and proinflammatory cytokines using a validated liquid chromatography-tandem mass spectrometry and enzyme-linked immunosorbent assay methods, respectively. Read More

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http://dx.doi.org/10.1002/jcph.1422DOI Listing
April 2019
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Pharmacokinetics of the recombinant ovine interferon-tau in lambs.

Pol J Vet Sci 2019 Mar;22(1):75-82

Department of Microbiology, Anhui Medical University, Hefei, Anhui Province, 230032, China.

In the current study, twenty lambs, aged 4 months, half male and half female, were classified into four groups, with five in each group. The experimental three groups of lambs were given intravenous (IV), intramuscular (IM) and subcutaneous (SC) administrations of recombinant ovine interferon-τ (roIFN-τ). The fourth group (normal control) of lambs was given normal saline injections in the same way. Read More

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http://journals.pan.pl/dlibra/publication/125610
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http://dx.doi.org/10.24425/pjvs.2018.125610DOI Listing
March 2019
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Activated cytotoxic T cells within zoonotic cutaneous leishmaniasis lesions.

Immun Inflamm Dis 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Transmission, Control and Immunobiology of Infections, Pasteur Institute of Tunis, Tunis, Tunisia.

Introduction: Zoonotic cutaneous leishmaniasis (ZCL), due to infection by Leishmania (L). major, is characterized by polymorphic clinical manifestations which could be attributed to the host's immune response. In this study we investigated the involvement of cytotoxic cells on the outcome of the disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iid3.240
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http://dx.doi.org/10.1002/iid3.240DOI Listing
April 2019
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BRAF mutation status might contribute an effect on both disease-free and overall survival in stage III cutaneous melanomas treated with intermediate dose interferon-alpha.

Cancer Chemother Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Oncology, Institute of Oncology, University of Istanbul, Capa, 34390, Istanbul, Turkey.

Purpose: The interaction between interferon treatment and BRAF mutation status among melanoma patients have yet to be evaluated. The present study aims to assess the intermediate dose interferon (IDI) in stage III melanoma patients with respect to BRAF mutation status.

Methods: A total of 46 adult lymph node-positive primary skin melanoma patients (23 BRAF-mutant and 23 BRAF-wild) with available information on the mutational status of the oncogene BRAF V600E were included in the analysis. Read More

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http://dx.doi.org/10.1007/s00280-019-03842-1DOI Listing

Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies.

Kidney Int Rep 2019 Apr 21;4(4):541-550. Epub 2018 Dec 21.

Department of Pediatrics, Division of Pediatric Nephrology, Duke University, Durham, North Carolina, USA.

Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non-human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific antibodies (DSAs). Our aim was to examine serum cytokine profiles associated with AT1R-Ab and distinguish them from those associated with HLA DSA in serially collected blood samples from a cohort of pediatric renal transplant recipients.

Methods: Blood samples from 65 pediatric renal transplant recipients drawn during the first 3 months posttransplant, at 6, 12, and 24 months posttransplant, and during suspected episodes of kidney transplant rejection were tested for AT1R-Ab, HLA DSA, and a panel of 6 cytokines (tumor necrosis factor [TNF]-α, interferon [IFN]-γ, interleukin [IL]-8, IL-1β, IL-6, and IL-17). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183035
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http://dx.doi.org/10.1016/j.ekir.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451195PMC
April 2019
1 Read

Oncolytic Virus-Based Cytokine Expression to Improve Immune Activity in Brain and Solid Tumors.

Mol Ther Oncolytics 2019 Jun 20;13:14-21. Epub 2019 Mar 20.

The Research Institute at Nationwide Children's Hospital Center for Childhood Cancer and Blood Diseases, Columbus, OH 43205, USA.

Oncolytic viral therapy has gained significant traction as cancer therapy over the past 2 decades. Oncolytic viruses are uniquely designed both to lyse tumor cells through their replication and to recruit immune responses against virally infected cells. Increasingly, investigators are leveraging this immune response to target the immunosuppressive tumor microenvironment and improve immune effector response against bystander tumor cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23727705193001
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http://dx.doi.org/10.1016/j.omto.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453942PMC
June 2019
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Assessment of the specificity of a gamma-interferon test performed with specific antigens to detect bovine tuberculosis, after non-negative results to intradermal tuberculin testing.

Vet Rec Open 2019 17;6(1):e000335. Epub 2019 Mar 17.

Epidemiology of Animal Infectious Diseases Unit, Ecole Nationale Veterinaire d\'Alfort, Maisons-Alfort, France.

In cattle herds in France, cervical skin tests (STs) using simple intradermal tuberculin (SIT) are performed to detect bovine tuberculosis (bTB). When positive results are found on ST screening, the herd is considered to be 'under suspicion' and confined, raising economic issues. The suspicion can be lifted by carrying out a single intradermal cervical comparative test (SICCT) at least six weeks later. Read More

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http://vetrecordopen.bmj.com/lookup/doi/10.1136/vetreco-2019
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http://dx.doi.org/10.1136/vetreco-2019-000335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446210PMC
March 2019
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Vaccine potential of LenA and LcpA proteins of in combination with heat-labile enterotoxin, B subunit (LTB).

Iran J Microbiol 2019 Feb;11(1):39-47

Department of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: Leptospirosis is a zooanthroponosis caused by the genus of . It is an emerging public health problem due to its increasing incidence. The achievement to a vaccine that prevent from entrance of to the deeper tissues of the host is needed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462271PMC
February 2019

New all-oral HCV therapies for genotype 1: A final good-bye to interferon.

Authors:
Anna S F Lok

Clin Liver Dis (Hoboken) 2014 Jun 25;3(6):137-140. Epub 2014 Jun 25.

Division of Gastroenterology and Hepatology University of Michigan Ann Arbor MI.

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http://doi.wiley.com/10.1002/cld.369
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http://dx.doi.org/10.1002/cld.369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448721PMC
June 2014
1 Read

Hepatitis B virus treatment: Which patients should be treated with interferon?

Clin Liver Dis (Hoboken) 2013 Feb 1;2(1):18-20. Epub 2013 Mar 1.

From the Department of Gastroenterology and Hepatology, Erasmus MC University Hospital, Rotterdam, the Netherlands.

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http://doi.wiley.com/10.1002/cld.152
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http://dx.doi.org/10.1002/cld.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448606PMC
February 2013
1 Read

Shared and Distinct Functions of Type I and Type III Interferons.

Immunity 2019 Apr;50(4):907-923

Departments of Medicine, Pathology & Immunology, and Molecular Microbiology, and The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences. Here, we provide a comprehensive review of type I and type III IFN activities, highlighting shared and distinct features from molecular mechanisms through physiological responses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193014
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http://dx.doi.org/10.1016/j.immuni.2019.03.025DOI Listing
April 2019
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Retinal Transcriptome Analysis in the Treatment of Endotoxin-Induced Uveitis with Tetramethylpyrazine Eye Drops.

J Ocul Pharmacol Ther 2019 Apr 17. Epub 2019 Apr 17.

1 The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.

To investigate retinal gene expression of tetramethylpyrazine (TMP) eye drop-treated endotoxin-induced uveitis (EIU) in mice and to explore the mechanisms. The inflammatory signs of the anterior segment were evaluated, and clinical scores were graded. The retinal transcriptome from the TMP eye drop-treated and the untreated mice was identified by RNA sequencing (RNA-seq) strategy. Read More

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http://dx.doi.org/10.1089/jop.2018.0105DOI Listing

Normal and keloid fibroblasts are differentially influenced by IFN-γ and triamcinolone as well as by their combination.

Wound Repair Regen 2019 Apr 17. Epub 2019 Apr 17.

University Hospital Frankfurt Goethe University, Frankfurt/Main, Department of Dermatology, Venereology and Allergology, Germany.

Impaired wound healing as well as imbalanced cell proliferation and extracellular matrix synthesis and degeneration can cause aberrant scarring. The most severe impacts of such scarring on patients' lives are stigmatization and physical restriction. Although, a broad variety of combinatorial approaches with e. Read More

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http://dx.doi.org/10.1111/wrr.12722DOI Listing

Enhanced Mycobacterial Antigen-Induced Pro-Inflammatory Cytokine Production in Lymph Node Tuberculosis.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Lymph node tuberculosis (LNTB) is characterized by the enhanced baseline and antigen-specific production of type 1/17 cytokines and reduced baseline and antigen-specific production of interleukin (IL)-1β and IL-18 at the site of infection when compared with peripheral blood. However, the cytokine profile in the lymph nodes (LNs) of culture-positive LNTB (LNTB+) and negative LNTB (LNTB-) has not been examined. To address this, we have examined the baseline and mycobacterial antigen-stimulated cytokine levels of type 1 (interferon gamma [IFNγ], tumor necrosis factor alpha [TNFα], IL-2), type 2 (IL-4, IL-5, and IL-13), type 17 (IL-17A, IL-17F, and IL-22), pro-inflammatory (IL-1α, IL-1β, IL-18, and GM-CSF), and regulatory cytokines (IL-10, TGFβ) in the LN culture supernatants of LNTB+ and LNTB- individuals. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0834DOI Listing

Inflammation in Mild Cognitive Impairment due to Parkinson's disease, Lewy Body disease and Alzheimer's disease.

Int J Geriatr Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Institute of Neuroscience, Newcastle upon Tyne, United Kingdom.

Background: Inflammation appears to play a role in the progression of neurodegenerative diseases. However, little is known about inflammation during early stages of cognitive decline or whether this differs in different disease groups. We sought to investigate this by assessing the inflammatory profile in patients with Parkinson's disease with the early stages of cognitive impairment (PD-MCI), patients with prodromal Alzheimer's disease (MCI-AD), prodromal Lewy Body disease (MCI-LB) and controls. Read More

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http://dx.doi.org/10.1002/gps.5124DOI Listing
April 2019
3 Reads

Activation profiles of monocyte-macrophages and HDL function in healthy women in relation to menstrual cycle and in polycystic ovary syndrome patients.

Endocrine 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Padova, Italy.

Purpose: Hormonal status and menopause affect human macrophage function and cardiometabolic risk. In polycystic ovary syndrome (PCOS) patients the cardiometabolic risk increases through mechanisms that are largely unknown. We tested the hypotheses that macrophage activation is influenced by menstrual cycle and that ovarian dysfunction in PCOS patients is associated with altered macrophage inflammatory responses and cholesterol efflux capacity of serum HDL. Read More

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http://dx.doi.org/10.1007/s12020-019-01911-2DOI Listing
April 2019
1 Read

Dermatomyositis and MIG.

Authors:
F Ragusa

Clin Ter 2019 Mar-Apr;170(2):e142-e147

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Several studies demonstrated the presence of an elevated expression of chemokine (C-X-C motif) ligand (CXCL)9/monokine induced by interferon (IFN)-γ (MIG) on macrophages and in T cells in perimysial infiltrates of patients with dermatomyositis (DM), and of chemokine (C-X-C motif) receptor (CXCR)3 expression on the majority of T cells in the same patients. This underlines the importance of T helper 1-mediated immunity, and in particular the MIG/CXCR3 interaction, in the immunopathogenesis of DM. The importance of MIG has been confirmed by a study on patients with DM about the presence of chemokines and their receptors in infiltrating cells at the level of lesional skin. Read More

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http://dx.doi.org/10.7417/CT.2019.2124DOI Listing
April 2019
1 Read

-Acetyl-l-Cysteine Supplement in Early Life or Adulthood Reduces Progression of Diabetes in Nonobese Diabetic Mice.

Curr Dev Nutr 2019 Apr 28;3(4):nzy097. Epub 2018 Nov 28.

Department of Molecular Biology, School of Health Sciences, Ariel University, Ariel, Israel.

Background: Oxidative stress contributes to the pathologic process leading to the development, progression, and complications of type 1 diabetes (T1D).

Objective: The aim of this study was to investigate the effect of the antioxidant -acetyl-l-cysteine (NAC), supplemented during early life or adulthood on the development of T1D.

Methods: NAC was administered to nonobese diabetic (NOD) female mice during pregnancy and lactation, and the development of diabetes was followed in offspring. Read More

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http://dx.doi.org/10.1093/cdn/nzy097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459986PMC

Relapse Following Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia Apparently Due to Somatic Cell Evolution via Epigenetic Variation and Immune Selection.

Authors:
Neil S Greenspan

Pathog Immun 2019 27;4(1):79-84. Epub 2019 Feb 27.

Case Western Reserve University, Cleveland, Ohio.

In this brief commentary, I discuss a recently published study that documents the role of immune escape in relapse of acute myeloid leukemia (AML) after hematopoietic cell transplantation (HCT). Of particular interest, the mechanism identified by the authors for the ability of the malignant cells to evade destruction by host T cells is the loss of cell surface expression of HLA class II molecules based on processes other than mutation. The authors labeled this mechanism for altered cell surface display of HLA class II antigens "epigenetic. Read More

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https://paijournal.com/index.php/paijournal/article/view/285
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http://dx.doi.org/10.20411/pai.v4i1.285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423549PMC
February 2019
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Differences in Gene Expression in Older Compared With Younger Kidney Transplant Recipients.

Transplant Direct 2019 Apr 4;5(4):e436. Epub 2019 Mar 4.

Division of Hematology-Oncology, Department of Medicine, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Background: For the growing numbers of older transplant patients, increased incidence of infection and death compared with younger patients may limit the many benefits provided by transplantation. However, little is known about age-associated immune dysfunction in the older transplant recipient.

Methods: A cohort of 60 kidney transplant recipients, 23 older (≥ 60y) and 37 younger (30-59y), matched on antithymocyte induction and donor type (living vs deceased) was evaluated. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445656PMC
April 2019
1 Read

A Phase 1/2 Trial of MEC (Mitoxantrone, Etoposide, Cytarabine) in Combination with Ixazomib for Relapsed/ Refractory Acute Myeloid Leukemia.

Clin Cancer Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute.

Purpose: The prognosis of patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) remains poor and novel therapies are needed. The proteasome pathway represents a potential therapeutic target. A phase 1 trial of the second generation proteasome inhibitor, ixazomib in combination with MEC (mitoxantrone, etoposide, and cytarabine) was conducted in patients with R/R AML. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3886DOI Listing
April 2019
1 Read

Circulating growth/differentiation factor 15 is associated with human CD56 natural killer cell dysfunction and nosocomial infection in severe systemic inflammation.

EBioMedicine 2019 Apr 13. Epub 2019 Apr 13.

Department of Orthopedics and Trauma Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Electronic address:

Background: Systemic inflammation induced by sterile or infectious insults is associated with an enhanced susceptibility to life-threatening opportunistic, mostly bacterial, infections due to unknown pathogenesis. Natural killer (NK) cells contribute to the defence against bacterial infections through the release of Interferon (IFN) γ in response to Interleukin (IL) 12. Considering the relevance of NK cells in the immune defence we investigated whether the function of NK cells is disturbed in patients suffering from serious systemic inflammation. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.04.018DOI Listing

[The effect of NK-1R-siRNA on expression of inflammatory factors in allergic rhinitis].

Authors:
H Wang J Wu R X Zhang

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):280-285

Department of Otolaryngology, Huadong Hospital, Fudan University, Shanghai 200040, China.

To explore the effect of neurokinin-1 receptor small interfering RNA (NK-1R-siRNA) on the expression of inflammation factors in allergic rhinitis (AR). Twenty-four male SD rats were divided into three groups randomly (by random number table methord): NK-1R-siRNA group, negative control siRNA (NC-siRNA) group and saline group, with 8 rats in each group. SD rats were sensitized and challenged with ovalbumin (OVA) to induce AR. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.008DOI Listing
April 2019
2 Reads

Poxviral E3L ortholog (Viral Interferon resistance gene) of orf viruses of sheep and goats indicates species-specific clustering with heterogeneity among parapoxviruses.

Cytokine 2019 Apr 13;120:15-21. Epub 2019 Apr 13.

Division of Virology, ICAR-IVRI, Mukteswar 263 138, Nainital, Uttarakhand, India. Electronic address:

Orf is a contagious disease posing a serious threat to animal and human health. E3L is one of the evolutionarily acquired immunomodulatory proteins present in orf virus (ORFV) and is responsible for conferring resistance to interferons among poxviruses. Genetic analysis of ORFV isolates of different geographical regions including Indian subcontinent targeting viral interferon resistance (VIR) gene (a homolog of vaccinia virus E3L gene) revealed a high percentage of identity among themselves and other ORFV isolates at both nt and aa levels as compared to low identity among parapoxviruses (PPVs). Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.001DOI Listing
April 2019
2 Reads

Effects of dietary Radix Rehmanniae Preparata polysaccharides on the growth performance, immune response and disease resistance of Luciobarbus capito.

Fish Shellfish Immunol 2019 Apr 13;89:641-646. Epub 2019 Apr 13.

Suqian Institute of Agricultural Sciences, Jiangsu Academy of Agricultural Sciences, Suqian, 223800, China. Electronic address:

This work explores the effects of dietary Radix Rehmanniae Preparata polysaccharide (RRPP) supplementation on the growth performance, nonspecific immune responses, immune- and growth-related gene expression and disease resistance to Aeromonas hydrophila in Luciobarbus capito. Diets containing five concentrations of 0%, 0.05%, 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193026
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http://dx.doi.org/10.1016/j.fsi.2019.04.027DOI Listing
April 2019
2 Reads

Pharmacological inhibition of β-catenin prevents EndMT in vitro and vascular remodeling in vivo resulting from endothelial Akt1 suppression.

Biochem Pharmacol 2019 Apr 13;164:205-215. Epub 2019 Apr 13.

Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States; Department of Medicine, Vascular Biology Center and Cancer Center, Augusta University, Augusta, GA 30912, United States. Electronic address:

Endothelial to mesenchymal transition (EndMT), where endothelial cells acquire mesenchymal characteristics has been implicated in several cardiopulmonary, vascular and fibrotic diseases. The most commonly studied molecular mechanisms involved in EndMT include TGFβ, Notch, interleukin, and interferon-γ signaling. As of today, the contributions of Akt1, an important mediator of TGFβ signaling and a key regulator of endothelial barrier function to EndMT remains unclear. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.04.016DOI Listing

Oncogenic KRAS Drives Immune Suppression in Colorectal Cancer.

Cancer Cell 2019 Apr;35(4):535-537

Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA; Department of Breast Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. Electronic address:

In this issue of Cancer Cell, Liao et al. demonstrate that oncogenic KRAS drives an immune suppressive program in colorectal cancer by repressing IRF2 expression, which leads to downregulation of interferon responsive genes, enhanced expression of CXCL3 and recruitment of suppressive myeloid cells, and subsequent resistance to immune checkpoint blockade. Read More

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http://dx.doi.org/10.1016/j.ccell.2019.03.008DOI Listing
April 2019
1 Read

Eleutheroside B increase tight junction proteins and anti-inflammatory cytokines expression in intestinal porcine jejunum epithelial cells (IPEC-J2).

J Anim Physiol Anim Nutr (Berl) 2019 Apr 16. Epub 2019 Apr 16.

Jilin Provincial Key Lab of Animal Nutrition and Feed Science, Jilin Agricultural University, Changchun, China.

Eleutheroside B (EB) is a phenylpropanoid glycoside with anti-inflammatory properties, neuroprotective abilities, immunomodulatory effects, antinociceptive effects, and regulation of blood glucose. The aim of this study was to investigate the effects of EB on the barrier function in the intestinal porcine epithelial cells J2 (IPEC-J2). The IPEC-J2 cells were inoculated into 96-well plates at a density of 5 × 10 cells per well for 100% confluence. Read More

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http://dx.doi.org/10.1111/jpn.13087DOI Listing