1,183 results match your criteria Journal of Intensive Care Medicine[Journal]


A Low-Dose 4F-PCC Protocol for DOAC-Associated Intracranial Hemorrhage.

J Intensive Care Med 2019 Apr 14:885066619840992. Epub 2019 Apr 14.

3 Department of Pharmacy, NewYork-Presbyterian Hospital, The Allen Hospital, New York, NY, USA.

Purpose: Current guidelines favor 4F-PCC over plasma for reversal of warfarin. Uncertainty remains on the hemostatic effectiveness and thrombotic risk of 4F-PCC for direct-acting oral anticoagulants (DOACs), particularly in patients with intracranial hemorrhage (ICH). This study sought to evaluate the effectiveness and safety of a lower dose protocol of 25 units/kg 4F-PCC for the management of DOAC-associated ICH in a real-world setting. Read More

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http://dx.doi.org/10.1177/0885066619840992DOI Listing
April 2019
3 Reads

Stimulant Therapy in Acute Traumatic Brain Injury: Prescribing Patterns and Adverse Event Rates at 2 Level 1 Trauma Centers.

J Intensive Care Med 2019 Apr 9:885066619841603. Epub 2019 Apr 9.

4 Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background/objective: Pharmacological stimulant therapies are routinely administered to promote recovery in patients with subacute and chronic disorders of consciousness (DoC). However, utilization rates and adverse drug event (ADE) rates of stimulant therapies in patients with acute DoC are unknown. We aimed to determine the frequency of stimulant use and associated ADEs in intensive care unit (ICU) patients with acute DoC caused by traumatic brain injury (TBI). Read More

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http://dx.doi.org/10.1177/0885066619841603DOI Listing
April 2019
1 Read

Serum Amyloid A1 as a Potential Intracranial and Extracranial Clinical Severity Biomarker in Traumatic Brain Injury.

J Intensive Care Med 2019 Apr 8:885066619837913. Epub 2019 Apr 8.

1 Department of Neurosurgery, Neurotraumatology and Subarachnoid Hemorrhage Research Unit, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain.

Extracranial injury is frequently present in patients with traumatic brain injury (TBI). However, no reliable biomarker exists nowadays to evaluate the magnitude and extension of extracranial injury as well as the identification of patients who are at risk of developing secondary injuries. The purpose of this study was to identify new possible peptide biomarkers by mass spectrometry analysis in patients with TBI and ascertain whether the novel biomarker discovered by peptide mass fingerprinting, serum amyloid A1 (SAA1), is capable of reflecting the condition of the patient and both intracranial and extracranial injury extension. Read More

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http://dx.doi.org/10.1177/0885066619837913DOI Listing
April 2019
1 Read

Serum Cortisol as an Early Biomarker of Cardiopulmonary Parameters Within the First 24 Hours After Aneurysmal Subarachnoid Hemorrhage in Intensive Care Unit Patients.

J Intensive Care Med 2019 Mar 26:885066619837910. Epub 2019 Mar 26.

2 Department of Neurosurgery, Bremen-Mitte Hospital, Bremen, Germany.

Objective:: Cardiopulmonary complications/stress are well-known phenomena in patients after aneurysmal subarachnoid hemorrhage (aSAH) and might be associated with an elevated serum troponin I (TNI) level. Since the glucocorticoid hormone cortisol is released during stress situations, the present study was conducted to investigate the influence of serum cortisol (SC) on cardiac and pulmonary parameters in patients after aSAH within the first 24 hours of intensive care unit (ICU) treatment.

Patients And Methods:: We retrospectively analyzed a cohort of 104 patients with aSAH admitted to our emergency department between January 2008 and April 2017. Read More

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http://dx.doi.org/10.1177/0885066619837910DOI Listing
March 2019
1 Read

A Retrospective Analysis of Nonocclusive Mesenteric Ischemia in Medical and Surgical ICU Patients: Clinical Data on Demography, Clinical Signs, and Survival.

J Intensive Care Med 2019 Mar 25:885066619837911. Epub 2019 Mar 25.

4 Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

Background:: To analyze demography, clinical signs, and survival of intensive care patients diagnosed with nonocclusive mesenteric ischemia (NOMI) and to evaluate the effect of a local intra-arterial prostaglandin therapy.

Methods:: Retrospective observational study screening 455 intensive care patients with acute arterial mesenteric perfusion disorder in a tertiary care hospital within the past 8 years. Lastly, 32 patients with NOMI were enrolled, of which 11 received local intra-arterial prostaglandin therapy. Read More

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http://dx.doi.org/10.1177/0885066619837911DOI Listing
March 2019
3 Reads

Safety and Putative Benefits of Tracheostomy Tube Placement in Patients on Extracorporeal Membrane Oxygenation: A Single-Center Experience.

J Intensive Care Med 2019 Mar 21:885066619837939. Epub 2019 Mar 21.

2 Critical Care Research Group, Adult Intensive Care Unit, The Prince Charles Hospital and University of Queensland, Brisbane, Queensland, Australia.

Purpose:: Patients supported with extracorporeal membrane oxygenation (ECMO) have been reported to have increased sedation requirements. Tracheostomies are performed in intensive care to facilitate longer term mechanical ventilation, reduce sedation, improve patient comfort, secretion clearance, and ability to speak and swallow. We aimed to investigate the safety of tracheostomy (TT) placement on ECMO, its impact on fluid intake, and the use of sedative, analgesic, and vasoactive drugs. Read More

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http://dx.doi.org/10.1177/0885066619837939DOI Listing
March 2019
1 Read

Effectiveness of a Transesophageal Echocardiography Course.

J Intensive Care Med 2019 Mar 13:885066619836665. Epub 2019 Mar 13.

7 Hofstra Northwell School of Medicine, New Hyde Park, NY, USA.

Background:: Transesophageal echocardiography has important applications for the management of the critically ill patient. There is a need to develop effective training programs for the critical care community in acquiring skill at critical care transesophageal echocardiography.

Objective:: We studied the effectiveness of a 1-day simulation-based course that focused on the acquisition of skill in the performance of critical care transesophageal echocardiography. Read More

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The Performance of Diagnostic Criteria for Hemophagocytic Lymphohistiocytosis in Critically Ill Patients.

J Intensive Care Med 2019 Mar 12:885066619837139. Epub 2019 Mar 12.

4 Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.

Objective:: The diagnostic criteria for secondary hemophagocytic lymphohistiocytosis (HLH) have not been validated in the critically ill adult population. We set out to evaluate the performance of diagnostic criteria and determine the ferritin cutoff in critically ill adults.

Design:: A retrospective single-center study. Read More

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http://dx.doi.org/10.1177/0885066619837139DOI Listing

Characteristics and Outcomes of Patients With and Without Type 2 Diabetes Mellitus and Pulmonary Sepsis.

J Intensive Care Med 2019 Mar 6:885066619833910. Epub 2019 Mar 6.

3 Division of Pulmonary and Critical Care, Loma Linda University Health, Loma Linda, CA, USA.

Purpose:: To date, studies have provided conflicting results regarding the impact of type 2 diabetes mellitus (DM) on sepsis-related outcomes. Our objective is to understand the impact of type 2 DM in bacterial pneumonia and sepsis-related intensive care unit (ICU) outcomes.

Methods:: Retrospective study using Multiparameter Intelligent Monitoring in Intensive Care III database. Read More

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http://dx.doi.org/10.1177/0885066619833910DOI Listing
March 2019
1 Read

Outcomes in Medical Intensive Care Patients Housed in Geographically Distant Units.

J Intensive Care Med 2019 Mar 5:885066619835488. Epub 2019 Mar 5.

1 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.

Objective:: The purpose of this study is to determine whether in patients admitted to a medical intensive care unit (ICU) service there are outcome differences between those in a medical ICU bed ("home") and a geographically distant subspecialty ICU bed ("overflow").

Methods:: We performed a retrospective cohort study of 4091 patients admitted to a medical ICU of a large tertiary-care urban teaching hospital. Depending on bed availability, some patients were housed in surgical or cardiac subspecialty ICUs while still being cared for by the primary medical ICU service. Read More

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http://dx.doi.org/10.1177/0885066619835488DOI Listing

Preadmission Corticosteroid Therapy and the Risk of Respiratory Failure in Adults Without HIV Presenting With Pneumocystis Pneumonia.

J Intensive Care Med 2019 Feb 27:885066619834242. Epub 2019 Feb 27.

3 Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.

Background:: Corticosteroid therapy is a well-recognized risk factor for Pneumocystis pneumonia (PCP); however, it has also been proposed as an adjunct to decrease inflammation and respiratory failure.

Objective:: To determine the association between preadmission corticosteroid use and risk of moderate-to-severe respiratory failure at the time of PCP presentation.

Methods:: This retrospective cohort study evaluated HIV-negative immunosuppressed adults diagnosed with PCP at Mayo Clinic from 2006 to 2016. Read More

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http://dx.doi.org/10.1177/0885066619834242DOI Listing
February 2019

Incidence of Clinically Significant Hypotension Stratified by Vasopressin Duration.

J Intensive Care Med 2019 Jan;34(1):77-78

3 Department of Pulmonary/Critical Care, University of Arkansas for Medical Sciences College of Medicine, Little Rock, AR, USA.

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http://dx.doi.org/10.1177/0885066617745809DOI Listing
January 2019

Hemodynamic Instability Secondary to Vasopressin Withdrawal in Septic Shock.

J Intensive Care Med 2019 Jan;34(1):79-80

1 Department of Pharmacy, University of Kentucky Medical Center, Lexington, KY, USA.

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http://dx.doi.org/10.1177/0885066617745810DOI Listing
January 2019
2 Reads

Cerebral Autoregulation-Guided Optimal Blood Pressure in Sepsis-Associated Encephalopathy: A Case Series.

J Intensive Care Med 2019 Feb 13:885066619828293. Epub 2019 Feb 13.

1 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background:: Impaired cerebral autoregulation and cerebral hypoperfusion may play a critical role in the high morbidity and mortality in patients with sepsis-associated encephalopathy (SAE). Bedside assessment of cerebral autoregulation may help individualize hemodynamic targets that optimize brain perfusion. We hypothesize that near-infrared spectroscopy (NIRS)-derived cerebral oximetry can identify blood pressure ranges that enhance autoregulation in patients with SAE and that disturbances in autoregulation are associated with severity of encephalopathy. Read More

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http://dx.doi.org/10.1177/0885066619828293DOI Listing
February 2019
15 Reads

A Regional, Cost-Effective, Collaborative Model for Critical Care Fellows' Ultrasonography Education.

J Intensive Care Med 2019 Feb 12:885066619828951. Epub 2019 Feb 12.

2 Division of Pulmonary, Critical Care and Sleep Medicine, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY, USA.

Objective:: Training in critical care ultrasonography is an essential tool in critical care medicine and recommended for fellowship programs in pulmonary and critical care medicine. Major barriers to implementing competency-based training in individual fellowship programs include a lack of expert faculty, time, and funding. Our objective was to investigate whether regional collaboration to deliver an introductory critical care ultrasonography course for fellows might overcome these barriers while achieving international training standards. Read More

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http://dx.doi.org/10.1177/0885066619828951DOI Listing
February 2019

The 24-Hour Intensivists Staffing Model Improves the Outcome for Nighttime Admitted Patients: A Matched Historical Control Study.

J Intensive Care Med 2019 Feb 11:885066619828338. Epub 2019 Feb 11.

1 Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

Introduction:: We previously showed that a "10-hour daytime on-site" and "nighttime (NT) on-call" staffing strategy was associated with higher mortality for intensive care unit (ICU) patients admitted during NT than it was for patients admitted during office hours (OH). In here, we evaluated the clinical effects of a 24-hour intensivist staffing model.

Methods:: We formed an intervention group of 3034 consecutive ICU patients hospitalized from January 2013 to December 2015, and a control group of 2891 patients from our previous study (2009-2011). Read More

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http://dx.doi.org/10.1177/0885066619828338DOI Listing
February 2019

The Risk of Acute Kidney Injury in Critically Ill Patients Receiving Concomitant Vancomycin With Piperacillin-Tazobactam or Cefepime.

J Intensive Care Med 2019 Feb 10:885066619828290. Epub 2019 Feb 10.

2 Department of Pharmacy Practice, Midwestern University College of Pharmacy-Glendale, Glendale, AZ, USA.

Purpose:: The objective of this study was to compare the incidence of acute kidney injury (AKI) among critically ill patients receiving combination therapy with vancomycin plus piperacillin-tazobactam (VPT) against patients receiving vancomycin plus cefepime (VC).

Methods:: A retrospective cohort study of adult patients admitted to an intensive care unit between September 2012 and December 2016 was conducted. Patients were included if they received combination therapy with VPT or VC for ≥48 hours. Read More

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http://dx.doi.org/10.1177/0885066619828290DOI Listing
February 2019
1 Read

Current Use and Impact on 30-Day Mortality of Pulmonary Artery Catheter in Cardiogenic Shock Patients: Results From the CardShock Study.

J Intensive Care Med 2019 Feb 7:885066619828959. Epub 2019 Feb 7.

12 Critical Care Department, Hospital Sant Joan Despi Moisès Broggi, Consorci Sanitari Integral, University of Barcelona, Barcelona, Spain.

Background:: Cardiogenic shock (CS) is the most life-threatening manifestation of acute heart failure. Its complexity and high in-hospital mortality may justify the need for invasive monitoring with a pulmonary artery catheter (PAC).

Methods:: Patients with CS included in the CardShock Study, an observational, prospective, multicenter, European registry, were analyzed, aiming to describe the real-world use of PAC, evaluate its impact on 30-day mortality, and the ability of different hemodynamic parameters to predict outcomes. Read More

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http://dx.doi.org/10.1177/0885066619828959DOI Listing
February 2019
4 Reads

Effectiveness of Treatments and Diagnostic Tools and Declining Mortality in Patients With Severe Sepsis: A 12-Year Population-Based Cohort Study.

J Intensive Care Med 2019 Jan 30:885066619827270. Epub 2019 Jan 30.

2 Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou.

Sepsis is a major cause of morbidity and mortality worldwide. With the advance of medical care, the mortality of sepsis has decreased in the past decades. Many treatments and diagnostic tools still lack supporting evidence. Read More

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http://dx.doi.org/10.1177/0885066619827270DOI Listing
January 2019
1 Read

Nonbeneficial Intensive Care: Misalignments Between Provider Assessments of Benefit and Use of Invasive Treatments.

J Intensive Care Med 2019 Jan 29:885066619826044. Epub 2019 Jan 29.

2 Division of Respiratory and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.

Background:: The purpose of this study was to examine how frequently invasive intensive care unit (ICU) treatments are delivered to critically ill patients despite clinicians' impressions that ICU care may be nonbeneficial.

Methods:: Patients admitted to the medical ICU of an academic public hospital were prospectively categorized according to guidelines from the Society of Critical Care Medicine which classifies patients based on severity of illness and likelihood of recovery (categories 1-4). Clinical data and use of ICU treatments in patients with high (category 1) and low (category 3) likelihoods of benefit were collected by chart review. Read More

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http://journals.sagepub.com/doi/10.1177/0885066619826044
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http://dx.doi.org/10.1177/0885066619826044DOI Listing
January 2019
4 Reads

Mortality and Prognostic Prediction in Very Elderly Patients With Severe Pneumonia.

J Intensive Care Med 2019 Jan 24:885066619826045. Epub 2019 Jan 24.

1 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si, Republic of Korea.

Introduction:: Although prognostic prediction scores for pneumonia such as CURB-65 score or pneumonia severity index (PSI) are widely used, there were a few studies in very elderly patients. The aim of the study was to validate prognostic prediction scores for severe pneumonia and investigate risk factors associated with in-hospital mortality of severe pneumonia in very elderly patients.

Methods:: During the 6-year study period (from October 2012 to May 2018), 160 patients aged 80 or older admitted to medical intensive unit were analyzed retrospectively. Read More

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http://dx.doi.org/10.1177/0885066619826045DOI Listing
January 2019
2 Reads

Feasibility, Reliability, Responsiveness, and Validity of the Patient-Reported Functional Scale for the Intensive Care Unit: A Pilot Study.

J Intensive Care Med 2019 Jan 22:885066618824534. Epub 2019 Jan 22.

1 Faculty of Health Sciences, School of Rehabilitation Science, McMaster University, Institute of Applied Health Sciences, Hamilton, Ontario, Canada.

Background:: Although many performance-based measures assess patients' physical function in intensive care unit (ICU) survivors, to our knowledge, there are no patient-reported ICU rehabilitation-specific measures assessing function. We developed the Patient-Reported Functional Scale-ICU (PRFS-ICU), which measures patients' perceptions of their ability to perform 6 activities (rolling, sitting edge of bed, sit-to-stand and bed-to-chair transfers, ambulation, and stair climbing). Each item is scored from 0 (unable) to 10 (able to perform at pre-ICU level) to a maximum of 60. Read More

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http://dx.doi.org/10.1177/0885066618824534DOI Listing
January 2019

Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective.

J Intensive Care Med 2019 Jan 17:885066618824531. Epub 2019 Jan 17.

1 Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Acute kidney injury (AKI) is a common and serious medical condition associated with significant increases in morbidity, mortality, and cost of care. Because of the high incidence and poor outcomes associated with AKI, there has been significant interest in the development of new therapies for the prevention and treatment of the disease. A lack of efficacy in drug trials led to the concern that AKI was not being diagnosed early enough for an effective intervention and that a rise in serum creatinine itself is not a sensitive-enough marker. Read More

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http://dx.doi.org/10.1177/0885066618824531DOI Listing
January 2019
3 Reads

A Nationwide Comparison Between Sepsis-2 and Sepsis-3 Definition in Japan.

J Intensive Care Med 2019 Jan 13:885066618823151. Epub 2019 Jan 13.

1 Department of Emergency Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background:: Currently, it remains controversial whether the Sepsis-3 definition provides the most appropriate criteria for clinical use. The purpose of this study was to compare between the Sepsis-2 and Sepsis-3 definitions using Japan's nationwide registry.

Methods:: Data were obtained from a multicenter registry conducted at 42 intensive care units (ICUs) throughout Japan, in which patients received treatment for severe sepsis or septic shock between January 2011 and December 2013. Read More

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http://dx.doi.org/10.1177/0885066618823151DOI Listing
January 2019
10 Reads

Clinical Trial Assessment of Intermittent and Continuous Infusion Dose of N-Acetylcysteine on Redox Status of the Body in Patients with Sepsis Admitted to the ICU.

J Intensive Care Med 2019 Jan 13:885066618823152. Epub 2019 Jan 13.

6 Surgical Oncology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose:: Conflicting results exist regarding the efficacy of N-acetyl cysteine (NAC) in sepsis treatment. A pivotal factor affecting the therapeutic potency of NAC in sepsis is timing and dosing of its infusion. We aimed to assess the effect of NAC on redox status of patients with sepsis and to compare its efficacy in intermittent and continuous infusion with the objective of developing the infusion regimen and optimizing the timing. Read More

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http://dx.doi.org/10.1177/0885066618823152DOI Listing
January 2019
3 Reads

Conservative Fluid Management After Sepsis Resuscitation: A Pilot Randomized Trial.

J Intensive Care Med 2019 Jan 10:885066618823183. Epub 2019 Jan 10.

1 Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Rationale:: The feasibility and clinical outcomes of conservative fluid management after sepsis resuscitation remain unknown.

Objectives:: To evaluate the effect of a conservative fluid management protocol on fluid balance and intensive care unit (ICU)-free days among patients with sepsis.

Methods:: In a single-center phase II/III randomized trial, we enrolled adults with suspected infection, ≥2 systemic inflammatory response syndrome criteria, and either shock (mean arterial pressure <60 mm Hg or vasopressors) or respiratory insufficiency (mechanical ventilation or oxygen saturation <97% and fraction of inspired oxygen ≥0. Read More

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http://dx.doi.org/10.1177/0885066618823183DOI Listing
January 2019
9 Reads

Troponin I as an Early Biomarker of Cardiopulmonary Parameters Within the First 24 Hours After Nontraumatic Subarachnoid Hemorrhage in Intensive Care Unit Patients.

J Intensive Care Med 2019 Jan 8:885066618824568. Epub 2019 Jan 8.

2 Department of Neurosurgery, Bremen-Mitte Hospital, Bremen, Germany.

Objective:: The elevation of serum cardiac troponin I (TNI) in patients with nontraumatic subarachnoid hemorrhage (ntSAH) is a well-known phenomenon. However, the relation between elevated TNI and different cardiopulmonary parameters (CPs) within the first 24 hours after ntSAH is unknown. The present study was conducted to investigate the association between TNI and different CP in patients with ntSAH within the first 24 hours of intensive care unit (ICU) treatment. Read More

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http://dx.doi.org/10.1177/0885066618824568DOI Listing
January 2019
3 Reads

The Effect of High-Flow Nasal Oxygen Therapy on Postoperative Pulmonary Complications and Hospital Length of Stay in Postoperative Patients: A Systematic Review and Meta-Analysis.

J Intensive Care Med 2018 Dec 26:885066618817718. Epub 2018 Dec 26.

1 Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Objective:: To evaluate the effect of high-flow nasal cannula oxygen (HFNO) therapy on hospital length of stay (LOS) and postoperative pulmonary complications (PPCs) in adult postoperative patients.

Data Sources:: PubMed, Embase, the Cochrane Library, Web of Science of Studies, China National Knowledge Index, and Wan Fang databases were searched until July 2018.

Study Selection:: Randomized controlled trials (RCTs) comparing HFNO with conventional oxygen therapy or noninvasive mechanical ventilation in adult postoperative patients were included. Read More

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http://dx.doi.org/10.1177/0885066618817718DOI Listing
December 2018
3 Reads

Passive Leg Raise: Feasibility and Safety of the Maneuver in Patients With Undifferentiated Shock.

J Intensive Care Med 2018 Dec 20:885066618820492. Epub 2018 Dec 20.

7 Division of Pulmonary and Critical Care, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Purpose:: Passive leg raise (PLR), in combination with technologies capable of capturing stroke volume changes, has been widely adopted in the management of shock. However, dedicated evaluation of safety, feasibility, and receptiveness of patients and nursing staff to PLR maneuver is missing.

Methods:: A noninterventional, prospective trial recruited adult patients with onset of undifferentiated shock within 24 hours with persistent vasopressor requirements despite fluid resuscitation. Read More

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http://journals.sagepub.com/doi/10.1177/0885066618820492
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http://dx.doi.org/10.1177/0885066618820492DOI Listing
December 2018
3 Reads

Novel Vasopressors in the Treatment of Vasodilatory Shock: A Systematic Review of Angiotensin II, Selepressin, and Terlipressin.

J Intensive Care Med 2018 Dec 18:885066618818460. Epub 2018 Dec 18.

5 University of Illinois Medical Center, IL, USA.

Study Objective:: Vasodilatory shock is the most common type of shock. Catecholamine vasopressors are the cornerstone of hemodynamic therapy but carry risks. Angiotensin II (AT) was recently approved, and other novel agents (selepressin and terlipressin) are under investigation and used outside the United States (terlipressin). Read More

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http://dx.doi.org/10.1177/0885066618818460DOI Listing
December 2018
3 Reads

Safety and Effectiveness of Intravenous Chlorpromazine for Agitation in Critically Ill Patients.

J Intensive Care Med 2018 Dec 17:885066618818787. Epub 2018 Dec 17.

1 Department of Pharmacy, Massachusetts General Hospital, Boston, MA, USA.

Background:: Agitation is common in the intensive care unit (ICU). Although antipsychotics are frequently used as first-line therapy, chlorpromazine has fallen out of favor due to risk of cardiovascular complications and severe hypotension. Although chlorpromazine is used anecdotally, there is a lack of data regarding its safety and effectiveness. Read More

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http://journals.sagepub.com/doi/10.1177/0885066618818787
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http://dx.doi.org/10.1177/0885066618818787DOI Listing
December 2018
3 Reads

Wells and Geneva Scores Are Not Reliable Predictors of Pulmonary Embolism in Critically Ill Patients: A Retrospective Study.

J Intensive Care Med 2018 Dec 16:885066618816280. Epub 2018 Dec 16.

4 Intensive Care Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.

Background:: Critically ill patients are at high risk for pulmonary embolism (PE). Specific PE prediction rules have not been validated in this population. The present study assessed the Wells and revised Geneva scoring systems as predictors of PE in critically ill patients. Read More

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http://dx.doi.org/10.1177/0885066618816280DOI Listing
December 2018
2 Reads

Authors' Response to the Intensive Care Unit Discharge Delay and In-Hospital Mortality.

J Intensive Care Med 2018 Dec 11:885066618816686. Epub 2018 Dec 11.

2 Laboratory for Computational Physiology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1177/0885066618816686DOI Listing
December 2018
29 Reads

The Role of Inflammatory Cytokines in Cardiac Arrest.

J Intensive Care Med 2018 Dec 10:885066618817518. Epub 2018 Dec 10.

1 Resuscitation Research Group, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Stony Brook University Medical Center, Stony Brook, NY, USA.

Introduction:: Post-cardiac arrest syndrome (PCAS) is characterized by systemic ischemia/reperfusion injury, anoxic brain injury, and post-arrest myocardial dysfunction superimposed on a precipitating pathology. The role of inflammatory cytokines in cardiac arrest remains unclear.

Aims:: We aimed to describe, with an emphasis on clinical applications, what is known about the role of inflammatory cytokines in cardiac arrest. Read More

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http://dx.doi.org/10.1177/0885066618817518DOI Listing
December 2018
2 Reads

Are Health-Care Providers Well Prepared in Providing Optimal End-of-Life Care to Critically Ill Patients? A Cross-Sectional Study at a Tertiary Care Hospital in the United States.

J Intensive Care Med 2018 Dec 3:885066618811794. Epub 2018 Dec 3.

4 Department of Pulmonary and Critical Care Medicine, Northwell Health Staten Island University Hospital, Staten Island, NY, USA.

It is important for health-care providers to be comfortable in providing end-of-life (EOL) care to critically ill patients and realizing when continuing aggressive measures would be futile. Therefore, there is a need to understand health-care providers' self-perceived skills and barriers to providing optimum EOL care. A total of 660 health-care providers from medicine and surgery departments were asked via e-mail to complete an anonymous survey assessing their self-reported EOL care competencies, of which 238 responses were received. Read More

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http://dx.doi.org/10.1177/0885066618811794DOI Listing
December 2018
2 Reads

Intensive Care Unit Discharge Delay and In-Hospital Mortality.

J Intensive Care Med 2018 Dec 4:885066618816673. Epub 2018 Dec 4.

2 Department of Critical Care Medicine, Northeast Georgia Health System, Gainesville, GA, USA.

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http://dx.doi.org/10.1177/0885066618816673DOI Listing
December 2018
2 Reads

Intensive Care Unit Capacity Strain and Outcomes of Critical Illness in a Resource-Limited Setting: A 2-Hospital Study in South Africa.

J Intensive Care Med 2018 Dec 4:885066618815804. Epub 2018 Dec 4.

8 Pietermaritzburg Department of Anaesthesia, Critical Care and Pain Management, Pietermaritzburg, South Africa.

Objective:: To measure the association of intensive care unit (ICU) capacity strain with processes of care and outcomes of critical illness in a resource-limited setting.

Methods:: We performed a retrospective cohort study of 5332 patients referred to the ICUs at 2 public hospitals in South Africa using the country's first published multicenter electronic critical care database. We assessed the association between multiple ICU capacity strain metrics (ICU occupancy, turnover, census acuity, and referral burden) at different exposure time points (ICU referral, admission, and/or discharge) with clinical and process of care outcomes. Read More

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http://dx.doi.org/10.1177/0885066618815804DOI Listing
December 2018
3 Reads

Management Strategies for Intracranial Pressure Crises in Subarachnoid Hemorrhage.

J Intensive Care Med 2018 Dec 4:885066618813073. Epub 2018 Dec 4.

4 Department of Neurology, Division of Neuroendovascular Surgery and Neurocritical Care, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Objectives: Standard management strategies for lowering intracranial pressure (ICP) in traumatic brain injury has been well-studied, but the use of lesser known interventions for ICP in subarachnoid hemorrhage (SAH) remains elusive. Searches were performed in PubMed and EBSCO Host to identify best available evidence for evaluation and management of medically refractory ICP in SAH. The role of standard management strategies such as head elevation, hyperventilation, mannitol and hypertonic saline as well as lesser known management such as sodium bicarbonate, indomethacin, tromethamine, decompressive craniectomy, decompressive laparotomy, hypothermia, and barbiturate coma are reviewed. Read More

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http://dx.doi.org/10.1177/0885066618813073DOI Listing
December 2018
3 Reads

Bedside Ultrasound Assessment of Lung Reaeration in Patients With Blunt Thoracic Injury Receiving High-Flow Nasal Cannula Oxygen Therapy: A Retrospective Study.

J Intensive Care Med 2018 Dec 4:885066618815649. Epub 2018 Dec 4.

1 Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background:: High-flow nasal cannula (HFNC) oxygen therapy has been shown to reduce the need for mechanical ventilation and decrease the duration of hospital and intensive care unit (ICU) stays for patients with a severely compromised respiratory system. This study aims to observe the evolution of lung aeration via lung ultrasound score (LUS) in a chest-injured population who had been treated with HFNC oxygen therapy, and to assess the benefit of the HFNC oxygen therapy in trauma patients.

Methods:: A retrospective study examined trauma patients with moderate to severe thoracic injuries who were admitted to the ICU at a tertiary hospital between October 2015 and March 2017. Read More

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December 2018
4 Reads

Devices to Reduce the Volume of Blood Taken for Laboratory Testing in ICU Patients: A Systematic Review.

J Intensive Care Med 2018 Nov 27:885066618810374. Epub 2018 Nov 27.

1 Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Background:: Intensive care unit (ICU) patients are at high risk of anemia, which is associated with adverse clinical outcomes and death. Blood sampling for diagnostic testing is a potentially modifiable contributor to anemia.

Methods:: We conducted a systematic review by searching MEDLINE and EMBASE from inception to October 5, 2017, for studies reporting the volume of blood taken for laboratory testing using blood sampling conservation devices compared to standard care or another intervention in adult ICU patients. Read More

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http://journals.sagepub.com/doi/10.1177/0885066618810374
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http://dx.doi.org/10.1177/0885066618810374DOI Listing
November 2018
7 Reads

Clinical Predictors for Unsafe Direct Discharge Home Patients From Intensive Care Units.

J Intensive Care Med 2018 Nov 26:885066618811810. Epub 2018 Nov 26.

1 Division of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Purpose:: To describe factors (demographics and clinical characteristics) that predict patients who are at an increased risk of adverse events or unplanned return visits to a health-care facility following discharge direct to home (DDH) from intensive care units (ICUs).

Methods:: Prospective cohort study of all adult patients who survived their stay in our medical-surgical-trauma ICU between February 2016 and 2017 and were discharged directly home. Patients were followed for 8 weeks postdischarge. Read More

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http://dx.doi.org/10.1177/0885066618811810DOI Listing
November 2018
11 Reads

Prevalence and Predictors of Deep Vein Thrombosis in Critically Ill Medical Patients Who Underwent Diagnostic Duplex Ultrasonography.

J Intensive Care Med 2018 Nov 19:885066618813300. Epub 2018 Nov 19.

2 Department of Pulmonary and Critical Care Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.

Introduction:: Deep vein thrombosis (DVT) is a recognized but preventable cause of morbidity and mortality in the medical intensive care unit (MICU). We examined the prevalence and risk factors for DVT in MICU patients who underwent diagnostic venous duplex ultrasonography (DUS) and the potential effect on clinical outcomes.

Methods:: This is a retrospective study examining prevalence of DVT in 678 consecutive patients admitted to a tertiary care level academic MICU from July 2014 to 2015. Read More

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http://dx.doi.org/10.1177/0885066618813300DOI Listing
November 2018
12 Reads

Interhospital Transfer of Children in Septic Shock: A Clinician Interview Qualitative Study.

J Intensive Care Med 2018 Dec 14;33(12):671-679. Epub 2016 Dec 14.

2 Child Health Evaluation and Research Unit, Division of General Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA.

Objective:: To determine the factors that influence the decision to transfer children in septic shock from level II to level I pediatric intensive care unit (PICU) care.

Design:: Interviews with level II PICU physicians in Michigan and Northwest Ohio. A hypothetical scenario of a 14-year-old boy in septic shock was presented. Read More

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http://dx.doi.org/10.1177/0885066616683662DOI Listing
December 2018
12 Reads

Cytomorphometric Neutrophil and Monocyte Markers May Strengthen the Diagnosis of Sepsis.

J Intensive Care Med 2018 Dec 13;33(12):656-662. Epub 2016 Dec 13.

2 Medical Intensive Care Unit, Christian Medical College, Vellore, Tamil Nadu, India.

Background:: The diagnosis of sepsis is challenging in the absence of a gold standard test. Recent studies have explored the role of neutrophil and monocyte volume, conductivity, and scatter (VCS), derived from automated hematology analyzers, in diagnosing sepsis. We assessed the diagnostic accuracy of VCS parameters in critically ill patients with sepsis. Read More

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http://dx.doi.org/10.1177/0885066616682940DOI Listing
December 2018
23 Reads

BiPAP Noninvasive Ventilation in Patients With Acute Heart Failure and Left Ventricular Systolic Dysfunction Without Control of Confusing Variables.

J Intensive Care Med 2018 12;33(12):695-696

1 Facultad de Ciencias Médicas, Universidad de Guayaquil, Ciudadela Universitaria Salvador Allende, Malecón del Salado entre Av Fortunato Safadi (Av Delta) y Av. Kennedy, Guayaquil, Guayas 090513, Ecuador.

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http://dx.doi.org/10.1177/0885066618758616DOI Listing
December 2018
2 Reads

Oncologic Emergencies-The Old, the New, and the Deadly.

J Intensive Care Med 2018 Nov 9:885066618803863. Epub 2018 Nov 9.

1 Critical Care Medicine Service, Department of Anesthesiology & Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Cancer continues to be a leading cause of death despite a broader understanding of its biology and the development of novel therapies. Nonetheless, with an increasing survival of this population, intensivists must be aware of the associated emergencies, both old and new. Oncologic emergencies can be seen as an initial presentation of the disease or precipitated by its treatment. Read More

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November 2018
17 Reads

Management of Hemophagocytic Lympho-Histiocytosis in Critically Ill Patients.

J Intensive Care Med 2018 Nov 1:885066618810403. Epub 2018 Nov 1.

1 Medical ICU, AP_HP Saint Louis hospital, Paris, France.

Hemophagocytic syndrome remains a rare but life-threatening complication and is associated with intensive care unit (ICU) admission. The pathophysiology is based on a defect of cytotoxicity in T cells that results in a state of hyperinflammation in the presence of a trigger. As a consequence, patients may develop multiorgan failure. Read More

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http://dx.doi.org/10.1177/0885066618810403DOI Listing
November 2018
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Effects of Early Enteral Nutrition on Immune Function and Prognosis of Patients With Sepsis on Mechanical Ventilation.

J Intensive Care Med 2018 Nov 1:885066618809893. Epub 2018 Nov 1.

1 Department of Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective:: To explore the therapeutic effects of early enteral nutrition (EEN) on patients with sepsis on mechanical ventilation.

Methods:: Patients with sepsis on mechanical ventilation in the medical intensive care unit (ICU) from January 2013 to March 2016 were treated with enteral nutrition. Patients treated within 48 hours of initiation of mechanical ventilation were assigned to the EEN group, and the rest were assigned to the delayed enteral nutrition (DEN) group. Read More

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http://journals.sagepub.com/doi/10.1177/0885066618809893
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http://dx.doi.org/10.1177/0885066618809893DOI Listing
November 2018
6 Reads

Relationship Between Near-Infrared Spectroscopy-Derived Cerebral Oxygenation and Delirium in Critically Ill Patients: A Systematic Review.

J Intensive Care Med 2018 Oct 30:885066618807399. Epub 2018 Oct 30.

1 Division of Neurology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.

Background:: A common neurological complication of critical illness is delirium, defined as an acute change in level of consciousness, with impaired attention and disorganized thinking. Patients with delirium have increased risk of long-term cognitive dysfunction and mortality. The cause is unknown, which limits our ability to design therapeutic interventions. Read More

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http://dx.doi.org/10.1177/0885066618807399DOI Listing
October 2018
7 Reads