208 results match your criteria Journal of Inflammation Research [Journal]


Alginate encapsulation for bupivacaine delivery and mesenchymal stromal cell immunomodulatory cotherapy.

J Inflamm Res 2019 12;12:87-97. Epub 2019 Mar 12.

Department of Anesthesiology, New York Methodist Hospital, Brooklyn, NY, USA.

Purpose: Mesenchymal stromal cells (MSCs) are used to treat various inflammatory conditions. In parallel, to mitigate pain associated with inflammation, analgesics or opioids are prescribed, often with significant side effects. Local anesthetics (LAs) offer a promising alternative to these medications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S192749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419600PMC
March 2019
4 Reads

Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats.

J Inflamm Res 2019 11;12:73-86. Epub 2019 Mar 11.

Department of Immunomorphology of Inflammation, Federal State Budgetary Institution "Science Research Institute of Human Morphology", Moscow, Russia,

Purpose: The aim of the study was to characterize the severity of the systemic inflammatory response induced by lipopolysaccharide (LPS) in animals with different resistance levels to hypoxia.

Materials And Methods: Two to three months old male Wistar rats (220-240 g) were divided according to hypoxia tolerance in a hypobaric chamber. After a month, they were injected intraperitoneally with LPS at a dose of 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S194581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417003PMC
March 2019
2 Reads

Oxidative stress and biochemical markers in prenatally androgenized sheep after neonatal treatment with GnRH agonist.

J Inflamm Res 2019 6;12:65-71. Epub 2019 Mar 6.

Laboratory of Biotechnology and Animal Reproduction - BioRep, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil,

Background: Disruption of the balance between the production of ROS and their removal through enzymatic and non-enzymatic (antioxidant) processes has been proposed as a new mechanism in the pathology of polycystic ovary syndrome (PCOS). Evidence from animal models of PCOS (prenatally androgenized sheep) has suggested that treatment with insulin sensitizers, but not antiandrogens, can reduce increases in ROS.

Materials And Methods: In the present study, we investigated the effects of neonatal treatment with a gonadotropin-releasing hormone (GnRH) agonist (leuprolide acetate) on prenatally androgenized sheep with testosterone propionate to determine its impact on oxidative stress molecules (ferric reducing antioxidant power [FRAP], advanced oxidation protein product [AOPP], nitric oxide [NOx], albumin) at 8, 12, and 18 months of age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S190260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408915PMC
March 2019
3 Reads

Particulate and solubilized β-glucan and non-β-glucan fractions of induce pro-and anti-inflammatory innate immune cell responses and exhibit antioxidant properties.

J Inflamm Res 2019 5;12:49-64. Epub 2019 Mar 5.

Kemin Industries, Plymouth, MI 48170, USA.

Purpose: The purpose of this work was to determine the pro-and anti-inflammatory properties of the single-cell organism (EG) and various fractions of its whole biomass.

Methods: Heterotrophically grown EG was tested, along with its aqueous fraction (E-AQ), the intact linear β-glucan paramylon granules (PAR), and alkaline-solubilized paramylon. Peripheral blood mononuclear cell cultures were treated with the test products and analyzed for a variety of cellular responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S191824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407518PMC

Pro-inflammatory agents released by pathogens, dying host cells, and neutrophils act synergistically to destroy host tissues: a working hypothesis.

J Inflamm Res 2019 23;12:35-47. Epub 2019 Jan 23.

Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI, USA.

We postulate that the extensive cell and tissue damage inflicted by many infectious, inflammatory and post-inflammatory episodes is an enled result of a synergism among the invading microbial agents, host neutrophils and dead and dying cells in the nidus. Microbial toxins and other metabolites along with the plethora of pro-inflammatory agents released from activated neutrophils massively recruited to the infectious sites and high levels of cationic histones, other cationic peptides, proteinases and Th1 cytokines released from activated polymorphonuclear neutrophils (PMNs) and from necrotized tissues may act in concert (synergism) to bring about cell killing and tissue destruction. Multiple, diverse interactions among the many potential pro-inflammatory moieties have been described in these complex lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S190007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350637PMC
January 2019
2 Reads

Myelin basic protein charge isomers change macrophage polarization.

J Inflamm Res 2019 23;12:25-33. Epub 2019 Jan 23.

Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia,

Purpose: During a neuronal injury, a variety of immune cells infiltrate into the local microenvironment at the demyelination site. After the destruction of the intact myelin sheath, its major constituent myelin basic protein (MBP) dissociates from the plasma membrane and acts as a free ligand on the infiltrated immune cells. MBP exhibits charge microheterogeneity as a result of post-translational modifications, but the effect of various isomers of MBP on the activity of macrophages is not known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S189570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350649PMC
January 2019
5 Reads

Erratum: Expression analysis of protein inhibitor of activated () genes in IFNβ-treated multiple sclerosis patients [Corrigendum].

Authors:

J Inflamm Res 2019 14;12:23. Epub 2019 Jan 14.

[This corrects the article on p. 457 in vol. 11, PMID: 30584347. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S200834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336134PMC
January 2019

Evaluation of cytokines in peripheral blood mononuclear cell supernatants for the diagnosis of tuberculosis.

J Inflamm Res 2019 24;12:15-22. Epub 2018 Dec 24.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA.

Introduction: There is active interest in leveraging host immune responses as biomarkers of tuberculosis (TB) disease activity. We had previously evaluated an immunodiagnostic test called the antibody in lymphocyte supernatant (ALS) assay. Here, we aimed to evaluate a panel of inflammatory mediators and associate the responses with the ALS results to identify a biosignature to distinguish TB cases from controls. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/evaluation-of-cytokines-in-periphe
Publisher Site
http://dx.doi.org/10.2147/JIR.S183821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307673PMC
December 2018
10 Reads

Epigenetics of chronic inflammatory diseases.

Authors:
Eleni Stylianou

J Inflamm Res 2019 20;12:1-14. Epub 2018 Dec 20.

Consultant Biomedical Scientist and Bioinformaticist, North Royalton, OH, USA,

Chronic, noncommunicable, and inflammation-associated diseases remain the largest cause of morbidity and mortality globally and within the United States. This is mainly due to our limited understanding of the molecular mechanisms that underlie these complex pathologies. The available evidence indicates that studies of epigenetics (traditionally defined as the heritable changes to gene expression that are independent of changes to DNA) are significantly advancing our knowledge of these inflammatory conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S129027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304253PMC
December 2018
2 Reads

Inflammasomes: Pandora's box for sepsis.

Authors:
Vijay Kumar

J Inflamm Res 2018 11;11:477-502. Epub 2018 Dec 11.

Children's Health Queensland Clinical Unit, School of Clinical Medicine, Faculty of Medicine, Mater Research, University of Queensland, Brisbane, Australia,

Sepsis was known to ancient Greeks since the time of great physician Hippocrates (460-377 BC) without exact information regarding its pathogenesis. With time and medical advances, it is now considered as a condition associated with organ dysfunction occurring in the presence of systemic infection as a result of dysregulation of the immune response. Still with this advancement, we are struggling for the development of target-based therapeutic approach for the management of sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S178084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294171PMC
December 2018
24 Reads

Expression analysis of protein inhibitor of activated () genes in IFNβ-treated multiple sclerosis patients.

J Inflamm Res 2018 6;11:457-463. Epub 2018 Dec 6.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Objectives: Protein inhibitors of activated STAT (PIAS) are transcription co-regulator of the Janus kinase/signal transducer and activator of transcription signaling pathway as well as nuclear factor-κB family of transcription factors. Both of them are involved in cytokine release during inflammatory response.

Patients And Methods: Considering the role of cytokine imbalance in the pathogenesis of multiple sclerosis (MS), we compared blood expressions of genes in 48 interferon β (IFNβ)-treated MS patients with those of healthy subjects by means of real time PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S187414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289119PMC
December 2018
1 Read

Therapeutic effects of physostigmine during systemic inflammation.

J Inflamm Res 2018 7;11:465-475. Epub 2018 Dec 7.

Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany,

Introduction: Usually, physostigmine is used as antidote for anticholinergic poisons in order to improve hemodynamics and cardiac output. In addition, it causes beneficial effects during sepsis when added timely. Here, we studied whether physostigmine improves hemodynamics when treatment during systemic inflammation was delayed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S187201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292228PMC
December 2018
1 Read

The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits.

J Inflamm Res 2018 13;11:447-456. Epub 2018 Nov 13.

Department of Emergency, Qilu Hospital, Shandong University, Jinan, China,

Background: The incidence of recurrent cardiovascular events from the progression of nontarget lesions (NTLs) is high for percutaneous coronary intervention-treated patients. However, the underlying mechanisms have not been thoroughly elucidated.

Methods: In this study, ten atherosclerotic rabbits with multiple plaques in the upper and lower segments of abdominal aorta (group A) were randomly divided into two subgroups: group A1 underwent intravascular ultrasound examination and stent implantation in the lower segments of the abdominal aorta (n=5), whereas group A2 was without stenting (n=5). Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/the-upregulated-scavenger-receptor
Publisher Site
http://dx.doi.org/10.2147/JIR.S179814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239100PMC
November 2018
10 Reads

Sex differences of inflammation in target organs, induced by intraperitoneal injection of lipopolysaccharide, depend on its dose.

J Inflamm Res 2018 8;11:431-445. Epub 2018 Nov 8.

Department of Pathology, Federal State Budgetary Institution "Science Research Institute of Human Morphology", Moscow, Russia.

Purpose: The aim of our research was to study sex differences and the severity of inflammatory changes in target organs and the peculiarities of immunological disorders when low and high doses of lipopolysaccharide (LPS) were administered to rats.

Methods: Male and female 2- to 3-month-old Wistar rats (200-250 g) were injected intraperitoneally with LPS in one of two doses: 1.5 or 15 mg/kg. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/sex-differences-of-inflammation-in
Publisher Site
http://dx.doi.org/10.2147/JIR.S178288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233486PMC
November 2018
24 Reads

Metformin ameliorated methotrexate-induced hepatorenal toxicity in rats in addition to its antitumor activity: two birds with one stone.

J Inflamm Res 2018 8;11:421-429. Epub 2018 Nov 8.

Department of Tropical, Faculty of Medicine, Tanta University, Tanta, Egypt,

Methotrexate (MTX) is a drug used in treatment of various malignancies. Unfortunately, it leads to life-threatening complications including hepatorenal toxicity. Previous studies revealed the protective effects of metformin (MET) on hepatorenal toxicity in other models in addition to its anticancer effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S178767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233475PMC
November 2018
19 Reads

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation.

J Inflamm Res 2018 30;11:407-419. Epub 2018 Oct 30.

Department of Oral Pathology, Medicine and Radiology, Indiana University School of Dentistry, Indiana University Purdue University at Indianapolis, Indianapolis, IN, USA,

The transcription factor NF-κB is a critical regulator of immune and inflammatory responses. In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel, and Rel-B proteins, which form homo- or heterodimers and remain as an inactive complex with the inhibitory molecules called IκB proteins in resting cells. Two distinct NF-κB signaling pathways have been described: 1) the canonical pathway primarily activated by pathogens and inflammatory mediators, and 2) the noncanonical pathway mostly activated by developmental cues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S140188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217131PMC
October 2018
11 Reads

2LARTH, a micro-immunotherapy medicine, exerts anti-inflammatory effects in vitro and reduces TNF-α and IL-1β secretion.

J Inflamm Res 2018 29;11:397-405. Epub 2018 Oct 29.

Clinical Affairs, Labo'Life Belgium, Gembloux, Belgium.

Background: Tumor necrosis factor-α (TNF-α) and IL-1β are 2 pro-inflammatory cytokines known to be involved in rheumatic diseases. The therapeutic strategy used in micro-immunotherapy (MI) to reduce chronic inflammation and attenuate pain consists in mainly targeting these 2 cytokines. 2LARTH is a sublingually administered medicine consisting of lactose-saccharose globules impregnated with ethanolic preparations of immune mediators and nucleic acids at ultra-low doses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S174326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211308PMC
October 2018
7 Reads

Evaluation of chemokine CXCL10 in human gingival crevicular fluid, saliva, and serum as periodontitis biomarker.

J Inflamm Res 2018 31;11:389-396. Epub 2018 Oct 31.

Abbvie, North Chicago, IL, USA.

Purpose: The aim of this study was to evaluate CXCL10 as a biomarker for periodontitis by determining the CXCL10 levels in saliva, serum, and gingival crevicular fluid (GCF) samples from periodontally healthy control subjects and adult subjects with chronic periodontitis.

Patients And Methods: Adult patients seeking dental treatment at Umm Al-Qura University dental clinic underwent a complete periodontal examination, and saliva, serum, and GCF samples were collected. Subjects were classified as chronic periodontitis patients (n=31) if they have a periodontal probing depth (PD) of ≥4 mm and/or clinical attachment level (CAL) of ≥3 mm in >30% of the teeth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S177188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216963PMC
October 2018
11 Reads

Regulatory T cells antagonize proinflammatory response of IL-17 during cutaneous tuberculosis.

J Inflamm Res 2018 28;11:377-388. Epub 2018 Sep 28.

Department of Dermatology, Safdarjung Hospital, New Delhi, India,

Background: The clinical forms of cutaneous tuberculosis (CTB) consist of a spectrum that reflects the host's immune response to ; it provides an ideal model to study the immunological dysregulation in humans. IL-17 plays an important role in initial immune response and is involved in both immune-mediated protection and pathology during infection. TGF-β producing regulatory T-cells (Tregs) are high in leprosy patients and responsible for immune suppression. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/regulatory-t-cells-antagonize-proi
Publisher Site
http://dx.doi.org/10.2147/JIR.S172878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168067PMC
September 2018
20 Reads

Erratum: Chronic tonsillitis and biofilms: a brief overview of treatment modalities [Corrigendum].

Authors:

J Inflamm Res 2018 28;11:375. Epub 2018 Sep 28.

[This corrects the article on p. 329 in vol. 11, PMID: 30233227. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S187032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168066PMC
September 2018
1 Read

Spotlight on the NLRP3 inflammasome pathway.

J Inflamm Res 2018 25;11:359-374. Epub 2018 Sep 25.

Centre International de Recherche en Infectiologie (CIRI), Université de Lyon, Lyon, France,

Inflammation is triggered by a repertoire of receptors detecting infections and damages. Some of these receptors directly bind microbial ligands, while others recognize endogenous molecules exposed under stress conditions, including infections. Most of these receptors can be engaged by a relatively limited number of stimuli. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/spotlight-on-the-nlrp3-inflammasom
Publisher Site
http://dx.doi.org/10.2147/JIR.S141220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161739PMC
September 2018
2 Reads

Inflammatory gene mRNA expression in human peripheral blood and its association with colorectal cancer.

J Inflamm Res 2018 24;11:351-357. Epub 2018 Sep 24.

Research Centre, Prince Sultan Military Medical City, Riyadh, Saudi Arabia,

Objective: The present study planned to investigate the changes in the mRNA expression of inflammatory genes and their association with colorectal cancer (CRC). Our findings could be useful for noninvasive early screening of CRC patients.

Patients And Methods: Venous blood of 20 CRC cases and 15 healthy controls was collected. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/inflammatory-gene-mrna-expression-
Publisher Site
http://dx.doi.org/10.2147/JIR.S155507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161717PMC
September 2018
10 Reads

The role of inflammation in irritable bowel syndrome (IBS).

J Inflamm Res 2018 21;11:345-349. Epub 2018 Sep 21.

National University Hospital, National University Health System, Singapore,

Irritable bowel syndrome (IBS) is a complex, functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort and altered bowel habits. Despite the global prevalence and disease burden of IBS, its underlying pathophysiology remains unclear. Inflammation may play a pathogenic role in IBS. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/the-role-of-inflammation-in-irrita
Publisher Site
http://dx.doi.org/10.2147/JIR.S174982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159811PMC
September 2018
3 Reads

Sacroiliitis - early diagnosis is key.

J Inflamm Res 2018 10;11:339-344. Epub 2018 Sep 10.

Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv, Israel.

Sacroiliitis, inflammation of the sacroiliac joint (SIJ), may be associated with many rheumatic and nonrheumatic disorders. The diagnosis of sacroiliitis may be difficult in many patients, and awareness of its typical manifestations along with recognition of its diverse presentations and cognizance of the limitations of today's imaging modalities are critical to good clinical practice. This review presents the didactic approach to the early diagnosis of sacroiliitis in patients with suspected axial spondyloarthritis and other nosologic entities, discussing also differential interpretation of information acquired from patients' histories, physical examination, and imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S149494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136407PMC
September 2018
3 Reads

Chronic tonsillitis and biofilms: a brief overview of treatment modalities.

J Inflamm Res 2018 5;11:329-337. Epub 2018 Sep 5.

Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kuala Lumpur, Malaysia,

Recurrent tonsillitis is described as when an individual suffers from several attacks of tonsillitis per year. Chronic and recurrent tonsillitis both cause repeated occurrences of inflamed tonsils which have a significant impact on a patient's quality of life. Numerous children suffer from recurrent tonsillitis and sore throats, and these illnesses become part of their life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S162486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134941PMC
September 2018
1 Read

Fecal microbiota transplant - a new frontier in inflammatory bowel disease.

J Inflamm Res 2018 31;11:321-328. Epub 2018 Aug 31.

Division of Gastroenterology, SBH Health System, Bronx, NY, USA.

Inflammatory bowel disease (IBD) is a chronic multifactorial disease that affects the gastrointestinal tract and results from an aberrant immune response toward luminal antigens in genetically susceptible people. Most of the current therapies for IBD focus on the management of the inflammation by using corticosteroids, immune modulators, and more recently, monoclonal antibodies (biological therapy). Although these therapies provide benefit in most cases, there are still a significant number of patients who do not respond or become refractory over time, suggesting the need for alternative therapeutic options. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S176190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124474PMC
August 2018
12 Reads

Current treatment of acute perforated diverticulitis: the role of damage control surgery.

J Inflamm Res 2018 17;11:319-320. Epub 2018 Aug 17.

Department of Oncology and Advanced technologies, Surgical Oncology Unit, AUSL-IRCCS of Reggio Emilia - Arcispedale Santa Maria Nuova, Reggio Emilia, Italy,

View Article

Download full-text PDF

Source
https://www.dovepress.com/current-treatment-of-acute-perfora
Publisher Site
http://dx.doi.org/10.2147/JIR.S177481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103557PMC
August 2018
20 Reads

Medicinal plants with anti-inflammatory activities from selected countries and regions of Africa.

J Inflamm Res 2018 7;11:307-317. Epub 2018 Aug 7.

Phytomedicine and Phytochemistry Group, Oxidative Stress Research Centre, Department of Biomedical Sciences, Faculty of Health and wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa,

Various nonsteroidal anti-inflammatory drugs have been shown to reduce pain and inflammation by blocking the metabolism of arachidonic acid by isoform of cyclooxygenase enzyme, thereby reducing the production of prostaglandin. Sadly, there are many side effects associated with the administration of nonsteroidal anti-inflammatory drugs. However, there are medicinal plants with anti-inflammatory therapeutic effects with low or no side effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S167789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086115PMC
August 2018
1 Read

Cell adhesion molecules and exercise.

J Inflamm Res 2018 24;11:297-306. Epub 2018 Jul 24.

Department of Kinesiology, George Mason University, Manassas, VA, USA.

Background: An extensive systematic review was undertaken in the current literature in order to explore the role of different types and intensities of exercise in cell adhesion molecules (CAMs), one of the markers of vascular inflammation, endothelial dysfunction, and atherosclerosis.

Methods: Twenty-eight qualifying studies were extensively reviewed to examine the effects of different intensities (low-to-moderate vs. high) and types (aerobic vs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S170262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063453PMC
July 2018
1 Read

IL-1α correlates with severity of hepatitis C virus-related liver diseases.

J Inflamm Res 2018 10;11:289-295. Epub 2018 Jul 10.

Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt,

Background And Aims: Immunoregulatory cytokines influence the persistence of hepatitis C virus (HCV) chronic infection and the extent of liver damage. Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some studies have demonstrated that IL-1α production was impaired in patients with chronic infections of HCV, implying that IL-1α may play a role in viral clearance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S166564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044361PMC
July 2018
12 Reads

The two faces of pannexins: new roles in inflammation and repair.

J Inflamm Res 2018 21;11:273-288. Epub 2018 Jun 21.

Bascom Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, USA.

Pannexins belong to a family of ATP-release channels expressed in almost all cell types. An increasing body of literature on pannexins suggests that these channels play dual and sometimes contradictory roles, contributing to normal cell function, as well as to the pathological progression of disease. In this review, we summarize our understanding of pannexin "protective" and "harmful" functions in inflammation, regeneration and mechanical signaling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S128401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016592PMC
June 2018
3 Reads

The effect of hydroalcoholic extract of on the inflammatory markers and lipid profile in hypercholesterolemic rats.

J Inflamm Res 2018 18;11:265-272. Epub 2018 Jun 18.

Department of Biochemistry, Faculty of Medicine, Ilam University of Medical sciences, Ilam, Iran.

Background: Cardiovascular diseases are among the most common causes of mortality worldwide. Therefore, it is necessary to control the risk factors of these patients. Since the level of inflammatory markers and lipid profiles has increased in cardiovascular diseases and due to the increasing role of plants in the treatment of diseases, the current study aimed to investigate the effect of hydroalcoholic extract of on inflammatory markers and lipid profile in hypercholesterolemic rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S165172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014391PMC
June 2018
4 Reads

Is there a link between inflammation and fatigue in multiple sclerosis?

J Inflamm Res 2018 7;11:253-264. Epub 2018 Jun 7.

EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est-Créteil, Créteil, France.

Purpose: Among autoimmune diseases of the central nervous system stands multiple sclerosis (MS), which is characterized by demyelination, synaptopathy, and neurodegeneration. MS fatigue can affect up to 90% of patients and be very disabling, with a drastic impact on their quality of life. To date, the evaluation of MS fatigue has relied mainly on subjective scales, and actual therapeutic interventions are challenged by modest efficacy and numerous undesirable effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S167199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995280PMC
June 2018
5 Reads

Factors correlated with the improvement of endothelial dysfunction during Abatacept therapy in patients with rheumatoid arthritis.

J Inflamm Res 2018 7;11:247-252. Epub 2018 Jun 7.

Immunology and Allergology Laboratory Unit, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro, Florence, Italy.

Background: Rheumatoid arthritis patients are exposed to a high risk of cardiovascular morbidity and mortality even in the early phases of the disease.

Methods: We evaluated carotid common carotid intimal media thickness (ccIMT) intimal thickness and brachial flow-mediated dilation (FMD) of 45 rheumatoid arthritis patients without known cardiovascular risk factors or heart disease on a stable dose of 5.2±1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S156822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995283PMC
June 2018
9 Reads

Inflammation management in acute diverticulitis: current perspectives.

J Inflamm Res 2018 30;11:239-246. Epub 2018 May 30.

Department of General Surgery, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

The pathogenesis of diverticular disease and acute diverticulitis is still unclear and many different hypotheses have been formulated. Seemingly, there are several related factors such as chronic inflammation, gut microbiome, obesity and the immunogenic properties of fat tissue and diet. Inflammation plays a pivotal role in diverticular disease and acute diverticulitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S142990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985778PMC
May 2018
3 Reads

Electroacupuncture therapy in inflammation regulation: current perspectives.

J Inflamm Res 2018 17;11:227-237. Epub 2018 May 17.

Department of Oriental Medicine, Daejeon University, Daejeon, South Korea.

Although acupuncture therapy is increasingly used to treat diverse symptoms and disorders in humans, its underlying mechanism is not known well. Only recently have experimental studies begun to provide insights into how acupuncture stimulation generates and relates to pathophysiological responsiveness. Acupuncture intervention is frequently used to control pathologic symptoms in several visceral organs, and a growing number of studies using experimental animal models suggest that acupuncture stimulation may be involved in inducing anti-inflammatory responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S141198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963483PMC
May 2018
3 Reads

Role of biologics and biosimilars in inflammatory bowel disease: current trends and future perspectives.

J Inflamm Res 2018 16;11:215-226. Epub 2018 May 16.

Department of Pharmacology, St John's Medical College, Bangalore, India.

Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory disease of the gastrointestinal system. The spectrum is of predominantly two types, namely, ulcerative colitis and Crohn's disease. The incidence of IBD has been increasing steadily since 1990, and so the number of agents used in their treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S165330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961645PMC
May 2018
20 Reads

A review of vagus nerve stimulation as a therapeutic intervention.

J Inflamm Res 2018 16;11:203-213. Epub 2018 May 16.

Lawrence D Longo MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, CA, USA.

In this review, we provide an overview of the US Food and Drug Administration (FDA)-approved clinical uses of vagus nerve stimulation (VNS) as well as information about the ongoing studies and preclinical research to expand the use of VNS to additional applications. VNS is currently FDA approved for therapeutic use in patients aged >12 years with drug-resistant epilepsy and depression. Recent studies of VNS in in vivo systems have shown that it has anti-inflammatory properties which has led to more preclinical research aimed at expanding VNS treatment across a wider range of inflammatory disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S163248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961632PMC
May 2018
4 Reads

Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols.

J Inflamm Res 2018 15;11:193-202. Epub 2018 May 15.

Laboratory of Biotechnology and Animal Reproduction, BioRep, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul.

Background: Several studies have described an enhanced inflammatory status and oxidative stress balance disruption in women with polycystic ovary syndrome (PCOS). However, there is scarce information about redox markers in the blood of androgenized animal models. Here, we evaluated the serum/plasma oxidative stress marker and metabolic parameter characteristics of prenatal (PreN) and postnatal (PostN) androgenized rat models of PCOS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S160264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960249PMC
May 2018
4 Reads

The role of neuroinflammation and neurovascular dysfunction in major depressive disorder.

J Inflamm Res 2018 8;11:179-192. Epub 2018 May 8.

Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea.

Although depression has generally been explained with monoamine theory, it is far more multifactorial, and therapies that address the disease's pathway have not been developed. In this context, an understanding of neuroinflammation and neurovascular dysfunction would enable a more comprehensive approach to depression. Inflammation is in a sense a type of allostatic load involving the immune, endocrine, and nervous systems. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/the-role-of-neuroinflammation-and-
Publisher Site
http://dx.doi.org/10.2147/JIR.S141033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947107PMC
May 2018
8 Reads

Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury.

J Inflamm Res 2018 1;11:169-178. Epub 2018 May 1.

Department of Anesthesiology and Operative Intensive Care Medicine, Charité - University Medicine Berlin, FreieUniversität Berlin, Humboldt-Universitätzu Berlin, and Berlin Institute of Health, Germany.

Purpose: Although the role of the angiotensin II type 2 (AT2) receptor in acute lung injury is not yet completely understood, a protective role of this receptor subtype has been suggested. We hypothesized that, in a rodent model of acute lung injury, stimulation of the AT2 receptor with the direct agonist Compound 21 (C21) might have a beneficial effect on pulmonary inflammation and might improve pulmonary gas exchange.

Materials And Methods: Male adult rats were divided into a treatment group that received pulmonary lavage followed by mechanical ventilation (LAV, n=9), a group receiving pulmonary lavage, mechanical ventilation, and direct stimulation of the AT2 receptor with C21 (LAV+C21, n=9), and a control group that received mechanical ventilation only (control, n=9). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S160573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935084PMC
May 2018
6 Reads

Immune-regulating effects of exercise on cigarette smoke-induced inflammation.

J Inflamm Res 2018 24;11:155-167. Epub 2018 Apr 24.

Department of Exercise and Health, Institute of Sports Science, Leibniz University Hannover, Germany.

Long-term cigarette smoking (LTCS) represents an important risk factor for cardiac infarction and stroke and the central risk factor for the development of a bronchial carcinoma, smoking-associated interstitial lung fibrosis, and chronic obstructive pulmonary disease. The pathophysiologic development of these diseases is suggested to be promoted by chronic and progressive inflammation. Cigarette smoking induces repetitive inflammatory insults followed by a chronic and progressive activation of the immune system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S141149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923223PMC
April 2018
6 Reads

Investigation of chronic efficacy and safety profile of two potential anti-inflammatory bipyrazole-based compounds in experimental animals.

J Inflamm Res 2018 3;11:143-153. Epub 2018 Apr 3.

Department of Pharmacology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Purpose: Although nonsteroidal anti-inflammatory drugs are widely used to treat a variety of disorders, their administration is associated with gastrointestinal side effects, acute kidney injury and liver enzymes' elevation. Accordingly, researchers are encouraged to create novel agents with better safety profile. The aim of the current study was to evaluate the chronic efficacy and safety profile of two compounds previously proven to have acceptable acute anti-inflammatory and analgesic activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S157955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892962PMC
April 2018
7 Reads

A meta-analysis of cyclosporine treatment for Stevens-Johnson syndrome/toxic epidermal necrolysis.

J Inflamm Res 2018 28;11:135-142. Epub 2018 Mar 28.

Department of Paediatrics, National University Hospital, National University Health System, Singapore.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are dermatologic emergencies with high morbidity and mortality risk. Cyclosporine, an immunomodulatory agent, is sometimes used off-label, and its role continues to be debated. This meta-analysis aimed to provide an update of current evidence and to clarify the role of cyclosporine in SJS/TEN treatment better. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S160964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880515PMC
March 2018
5 Reads

The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals.

J Inflamm Res 2018 26;11:123-134. Epub 2018 Mar 26.

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

Alpha-1 antitrypsin (AAT) is the most abundant serine protease inhibitor circulating in the blood. AAT deficiency (AATD) is an autosomal codominant condition affecting an estimated 3.4 million individuals worldwide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S156405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875399PMC
March 2018
4 Reads

Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review.

J Inflamm Res 2018 22;11:111-121. Epub 2018 Mar 22.

Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Canberra, ACT, Australia.

Studies examining post-traumatic stress disorder (PTSD) have either emphasized a relationship between PTSD and a systemically pro-inflammatory state or identified a link between PTSD and chronic disease. The aim of this study was to evaluate the evidence for a relationship between individuals with PTSD and systemic low-grade inflammation that has been proposed to underlie chronic disease development in this population. The authors conducted a systematic review of the literature (January 2006 to April 2017) in accordance with the PRISMA statement in the following four databases: PubMed, MEDLINE, PsycINFO, and SPORTDiscus with Full Text. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S155903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868606PMC
March 2018
13 Reads

Glucagon-like peptide-1 exerts anti-inflammatory effects on mouse colon smooth muscle cells through the cyclic adenosine monophosphate/nuclear factor-κB pathway in vitro.

J Inflamm Res 2018 20;11:95-109. Epub 2018 Mar 20.

Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Intestinal smooth muscle cells (SMCs) undergo substantial morphological, phenotypic, and contractile changes during inflammatory bowel disease (IBD). SMCs act as a source and target for different inflammatory mediators, however their role in IBD pathogenesis is usually overlooked. Glucagon-like peptide-1 (GLP-1) is an incretin hormone reported to exert multiple anti-inflammatory effects in different tissues including the gastrointestinal tract through various mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S152835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865574PMC
March 2018
6 Reads

Acute pancreatitis: current perspectives on diagnosis and management.

J Inflamm Res 2018 9;11:77-85. Epub 2018 Mar 9.

Department of Surgery, Hereford County Hospital, Hereford, UK.

The last two decades have seen the emergence of significant evidence that has altered certain aspects of the management of acute pancreatitis. While most cases of acute pancreatitis are mild, the challenge remains in managing the severe cases and the complications associated with acute pancreatitis. Gallstones are still the most common cause with epidemiological trends indicating a rising incidence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S135751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849938PMC
March 2018
7 Reads

Moderate glucose supply reduces hemolysis during systemic inflammation.

J Inflamm Res 2018 12;11:87-94. Epub 2018 Mar 12.

Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany.

Background: Systemic inflammation alters energy metabolism. A sufficient glucose level, however, is most important for erythrocytes, since erythrocytes rely on glucose as sole source of energy. Damage to erythrocytes leads to hemolysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S155614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856073PMC
March 2018
5 Reads

Exercise-induced changes in stress hormones and cell adhesion molecules in obese men.

J Inflamm Res 2018 1;11:69-75. Epub 2018 Mar 1.

Department of Health, Human Performance, Recreation, Baylor University, Waco, TX, USA.

Purpose: The current study examined the relationship between exercise-induced changes in stress hormones (epinephrine, norepinephrine, and cortisol) and vascular inflammatory markers (soluble intracellular adhesion molecule-1 [sICAM-1], soluble endothelial selectin [sE-selectin], and soluble vascular adhesion molecule-1 [sVCAM-1]) in obese men over a 24-hour period following exercise at lower and higher intensity.

Patients And Methods: Fifteen physically inactive, obese, college-aged men performed a single bout of cycling exercise at lower and higher intensities (lower intensity: 50% of maximal heart rate, and higher intensity: 80% of maximal heart rate) in random order. Overnight fasting blood samples were collected at baseline, immediately postexercise (IPE), 1-hour PE (1-h PE), and 24-hour PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S158294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836718PMC
March 2018
3 Reads