594 results match your criteria Journal of Inflammation [Journal]


Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease.

J Inflamm (Lond) 2019 2;16. Epub 2019 Apr 2.

1Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Background: Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of free cholesterol in macrophages leading to activation of NLRP3 inflammasome and production of interleukin-1β (IL-1β) has been linked to atherosclerosis-associated inflammation. However, it is not clear if cholesterol accumulation is associated with hepatic inflammation and fibrosis in the liver. Read More

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http://dx.doi.org/10.1186/s12950-019-0211-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444889PMC

SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren's syndrome.

J Inflamm (Lond) 2019 18;16. Epub 2019 Mar 18.

2Department of Ophthalmology, Hadassah-Hebrew University Medical Center, POB 12000, 91120 Jerusalem, Israel.

Background: Cytokines are known to be key players in dry eye syndrome (DES) and Sjogren's syndrome (SS) pathogenesis. In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine levels among SS and DES patients in Israel.

Methods: We recruited 180 subjects, 82 with SS and 98 with DES. Read More

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http://dx.doi.org/10.1186/s12950-019-0209-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421669PMC
March 2019
1 Read

Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK.

J Inflamm (Lond) 2019 18;16. Epub 2019 Mar 18.

5Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.

Background: Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons with a low intake of selenium. There are indications that one of the mechanisms of this positive effect is a decrease in inflammation. Read More

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http://dx.doi.org/10.1186/s12950-019-0210-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421641PMC

Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone.

J Inflamm (Lond) 2019 19;16. Epub 2019 Feb 19.

1Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193 Japan.

Background: Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular proteins. Ovarian cancer G protein-coupled receptor 1 (OGR1) senses extracellular protons and mediates the production of interleukin-6 (IL-6) and connective tissue growth factor (CTGF) in ASMCs. Read More

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http://dx.doi.org/10.1186/s12950-019-0207-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381743PMC
February 2019
2 Reads

LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture.

J Inflamm (Lond) 2019 18;16. Epub 2019 Feb 18.

2Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yan Jiang Xi Road, Guangzhou, 510120 China.

Background: Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe sepsis and septic shock. Read More

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https://journal-inflammation.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12950-019-0208-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378711PMC
February 2019
7 Reads

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis.

J Inflamm (Lond) 2019 29;16. Epub 2019 Jan 29.

1Bone and Joint Research Unit, Rheumatology Department, IIS-Fundación Jiménez Díaz UAM, Avenida Reyes Católicos, 2. 28040, Madrid, Spain.

Background: In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification with tofacitinib (TOFA), at flare-up in antigen induced arthritis (AIA). New Zealand rabbits were randomly assigned to four groups -healthy controls, AIA, TOFA-treated AIA, or TOFA-treated controls-. AIA was induced with 4 weekly intra-articular ovalbumin injections in sensitized animals. Read More

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https://journal-inflammation.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12950-019-0206-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352431PMC
January 2019
15 Reads

Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine.

J Inflamm (Lond) 2019 15;16. Epub 2019 Jan 15.

1Department of Morphology, Surgery and Experimental Medicine, Intensive Care Section, University of Ferrara, 44121 Ferrara, Italy.

Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region of 40%. There has been slow but incremental progress in identification of biomarkers that contribute to the pathophysiology of ARDS, have utility in diagnosis and monitoring, and that are potential therapeutic targets (Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, Thompson T, Ware LB, Matthay MA, Lancet Respir Med 2014, 2:611--620). However, a major issue is that ARDS is such a heterogeneous, multi-factorial, end-stage condition that the strategies for "lumping and splitting" are critical (Prescott HC, Calfee CS, Thompson BT, Angus DC, Liu VX, Am J Respir Crit Care Med 2016, 194:147--155). Read More

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http://dx.doi.org/10.1186/s12950-018-0202-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332898PMC
January 2019
4 Reads
2.024 Impact Factor

The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation.

J Inflamm (Lond) 2018 19;15:28. Epub 2018 Dec 19.

Central Lab, First People's Hospital of Wujiang Dist, Suzhou, 215200 Jiangsu Province China.

Background: Microglial inflammatory activation is the common feature of the central nervous system (CNS) diseases. Microglia can be activated and particularly polarized toward a dual role in the injured CNS. The CD200 receptor 1 (CD200R1) inhibits inflammatory microglia activation as illustrated by studies. Read More

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http://dx.doi.org/10.1186/s12950-018-0205-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300008PMC
December 2018
2 Reads

Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction.

J Inflamm (Lond) 2018 17;15:27. Epub 2018 Dec 17.

Departments of orthopedics, Affiliated Hospital of Nanjing University of TCM, Road Hanzhong 155#, Nanjing, Jiangsu Province, China.

Background: Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca), also known as a cellular second messenger. Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, and the activation of which causes an influx of cation ions, in particularly Ca, into the activated cells. Therefore, we investigate the potential role of TRPA1 in mediating Ca influx to promote chondrocyte apoptosis in OA. Read More

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http://dx.doi.org/10.1186/s12950-018-0204-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296079PMC
December 2018
1 Read

Dynamics of soluble vascular endothelial growth factor receptors and their ligands in aqueous humour during ranibizumab for age-related macular degeneration.

J Inflamm (Lond) 2018 4;15:26. Epub 2018 Dec 4.

1Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tatemachi, Hachioji, Tokyo, 193-0998 Japan.

Background: Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF receptor intraocular dynamics after IRI are unclear. Therefore, we evaluated changes in the aqueous humor levels of soluble vascular endothelial growth factor receptor (sVEGFR)-1, sVEGFR-2, and their ligands for these receptors (VEGF) patients with AMD receiving IRI.

Methods: The subjects were 24 patients with AMD (24 eyes) who received 3 doses of IRI at monthly intervals. Read More

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http://dx.doi.org/10.1186/s12950-018-0203-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280338PMC
December 2018
1 Read

Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages.

J Inflamm (Lond) 2018 4;15:25. Epub 2018 Dec 4.

1Department of Forensic Pathology, China Medical University School of Forensic Medicine, No.77, Puhe Road, Shenyang North New Area, Shenyang, 110122 Liaoning Province People's Republic of China.

Background: The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by regulating macrophage polarisation. Several research findings suggested that the activation of CB2R could attenuate inflammation by reducing pro-inflammatory M1 macrophage polarisation and promoting anti-inflammatory M2 polarisation. Read More

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http://dx.doi.org/10.1186/s12950-018-0201-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278147PMC
December 2018
5 Reads

Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling.

J Inflamm (Lond) 2018 26;15:24. Epub 2018 Nov 26.

1Laboratory of Food and Physiological Sciences, Department of Life and Food Sciences, School of Life and Environmental Sciences, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201 Japan.

Introduction: Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo conditions whether administration of lutein attenuates the inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons that is associated with mechanical hyperalgesia.

Results: Complete Freund's adjuvant (CFA) was injected into the whisker pads of rats to induce inflammation, and then mechanical stimulation was applied to the orofacial area to assess the threshold of escape. Read More

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http://dx.doi.org/10.1186/s12950-018-0200-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258298PMC
November 2018
2 Reads

Circulating natural antibodies to inflammatory cytokines are potential biomarkers for atherosclerosis.

J Inflamm (Lond) 2018 16;15:22. Epub 2018 Nov 16.

1Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041 China.

Background: Inflammatory cytokines contribute to the development of atherosclerosis. Natural antibodies in the circulation have protective effects on common diseases including atherosclerosis-related conditions.

Purpose: The present study aimed to investigate the possible involvement of circulating IgG antibodies against inflammatory cytokines in atherosclerosis. Read More

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https://journal-inflammation.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12950-018-0199-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240255PMC
November 2018
16 Reads

Contribution of the inflammasome to inflammaging.

J Inflamm (Lond) 2018 16;15:23. Epub 2018 Nov 16.

Department of Neurological Surgery, Lois Pope LIFE Center, The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, 1095 NW 14th Terrace, 3-25, Miami, FL 33136-1060 USA.

Background: Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer's disease and Parkinson's disease. Read More

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http://dx.doi.org/10.1186/s12950-018-0198-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240324PMC
November 2018
3 Reads

The severity of LPS induced inflammatory injury is negatively associated with the functional liver mass after LPS injection in rat model.

J Inflamm (Lond) 2018 15;15:21. Epub 2018 Nov 15.

2Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Friedrich-Schiller-University Jena, Drackendorferstraße1, 07747 Jena, Germany.

Background: High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigated. In the present study, the severity of LPS induced inflammatory response was observed after liver resection or portal branch occlusion to decreasing functional liver mass. Read More

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https://journal-inflammation.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12950-018-0197-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238277PMC
November 2018
19 Reads

ZNF580 - a brake on Interleukin-6.

J Inflamm (Lond) 2018 22;15:20. Epub 2018 Oct 22.

1Institute of Physiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Insitute of Health, Virchowweg 6/ CCO, Charitéplatz 1, 10117 Berlin, Germany.

Background: Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 could play a role during inflammation. Read More

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http://dx.doi.org/10.1186/s12950-018-0196-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198383PMC
October 2018
1 Read

The roles of IL-19 and IL-20 in the inflammation of degenerative lumbar spondylolisthesis.

J Inflamm (Lond) 2018 18;15:19. Epub 2018 Sep 18.

7Department of Orthopedics, Tainan Municipal An-Nan Hospital-China Medical University, Tainan, Taiwan.

Background: Degenerative lumbar spondylolisthesis (DLS) is a major cause of spinal canal stenosis and is often related to lower back pain. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory bone disorders likes intervertebral disc herniation, rheumatoid arthritis (RA), osteoporosis, and bone fracture. IL-19 also acts as a proinflammatory cytokine in RA. Read More

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https://journal-inflammation.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12950-018-0195-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145204PMC
September 2018
11 Reads

Contribution of diminished kidney transplant GFR to increased circulating chemokine ligand 27 level.

J Inflamm (Lond) 2018 10;15:18. Epub 2018 Sep 10.

4Department of Medicine, University of Saskatchewan, Saskatoon, SK Canada.

Background: Inflammatory chemokine ligands (CCLs) play an important role in cardiovascular disease and allograft injury. CCLs may independently associate with diminished estimated glomerular filtration rate (eGFR) in stable renal transplant recipients (RTR).

Methods: Plasma levels of 19 CCLs (1, 2, 3, 4, 5, 8, 11, 13, 15, 17, 21, 24, 26, 27, CXCL5, 8, 10, 12 and 13) were measured in a cohort of 101 RTR. Read More

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http://dx.doi.org/10.1186/s12950-018-0194-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131940PMC
September 2018
1 Read

In vitro suppression of inflammatory cytokine response by methionine sulfoximine.

J Inflamm (Lond) 2018 10;15:17. Epub 2018 Sep 10.

1Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Scott Hall, 540 E. Canfield Ave, Detroit, MI 48201 USA.

Background: The glutamine synthetase inhibitor methionine sulfoximine (MSO), shown previously to prevent death caused by an inflammatory liver response in mice, was tested on in vitro production of cytokines by mouse peritoneal macrophages triggered with lipopolysaccharide (LPS).

Results: MSO significantly reduced the production of Interleukin 6 (IL-6) and Tumor Necrosis Factor Alpha (TNFα) at 4 and 6 h after LPS-treatment. This reduction did not result from decreased transcription of IL-6 and TNFα genes, and therefore appeared to result from post-transcriptional inhibition of synthesis of these cytokines. Read More

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http://dx.doi.org/10.1186/s12950-018-0193-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131744PMC
September 2018
7 Reads

Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus.

J Inflamm (Lond) 2018 3;15:16. Epub 2018 Sep 3.

Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021 Shandong China.

Background: The aim of the study was to investigate the expression of the NEK7-NLRP3 inflammasome signaling pathway in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as well as its clinical significance.

Methods: A total of 38 SLE patients and 33 healthy volunteers were recruited. Real time PCR and western blotting were performed to determine mRNA and protein levels of , NLRP3 inflammasome components (, , and ), and downstream cytokines ( and ) in PBMCs from the two groups. Read More

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https://journal-inflammation.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12950-018-0192-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122698PMC
September 2018
4 Reads

MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α.

J Inflamm (Lond) 2018 20;15:15. Epub 2018 Aug 20.

3Department of Emergency, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011 People's Republic of China.

Background: T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) expression was increased in asthma patients. Read More

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http://dx.doi.org/10.1186/s12950-018-0191-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102869PMC
August 2018
7 Reads

Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair.

J Inflamm (Lond) 2018 20;15:14. Epub 2018 Jul 20.

4Department of Trauma and Orthopedics, The Second Hospital of Shandong University, Jinan, 250033 Shandong China.

Background: Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair. Hesperidin is a flavonoid extract from citrus fruits with anti-inflammatory properties. We aimed to investigate the effect of hesperidin on MSCs for cartilage tissue repair. Read More

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http://dx.doi.org/10.1186/s12950-018-0190-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053785PMC
July 2018
27 Reads

Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease.

J Inflamm (Lond) 2018 11;15:13. Epub 2018 Jul 11.

5Facultad de Medicina, Universidad Nacional Autónoma de México, Av. Ciudad Universitaria 3000, C.P. Coyoacán, 04360 México City, Mexico.

Background: The CARD family plays an important role in innate immune response by the activation of NF-κB. The aim of this study was to determine the gene expression and to enumerate the protein-expressing cells of some members of the CARD family (CARD9, CARD10, CARD11, CARD14 and CARD15) in patients with IBD and normal controls without colonic inflammation.

Methods: We included 48 UC patients, 10 Crohn's disease (CD) patients and 18 non-inflamed controls. Read More

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http://dx.doi.org/10.1186/s12950-018-0189-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042317PMC
July 2018
5 Reads

Experimental murine acute lung injury induces increase of pulmonary TIE2-expressing macrophages.

J Inflamm (Lond) 2018 14;15:12. Epub 2018 Jun 14.

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

Background: Breakdown of the alveolo-capillary wall is pathognomonic for Acute Lung Injury (ALI). Angiopoietins, vascular-specific growth factors, are linked to endothelial barrier dysfunction, and elevated Angiopoietin-2 (ANG2) levels are associated with poor outcome of ALI patients. Specialized immune cells, referred to as 'TIE2-expressing monocytes and macrophages' (TEM), were shown to specifically respond to ANG2 binding. Read More

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http://dx.doi.org/10.1186/s12950-018-0188-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001122PMC
June 2018
1 Read

The impact of septic stimuli on the systemic inflammatory response and physiologic insult in a preclinical non-human primate model of polytraumatic injury.

J Inflamm (Lond) 2018 24;15:11. Epub 2018 May 24.

1Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD USA.

Background: Established animal trauma models are limited in recapitulating the pathophysiology of human traumatic injury. Herein, we characterize the physiologic insult and inflammatory response in two clinically relevant non-human primate (NHP) trauma models.

Methods: Mauritian Cynomolgus Macaques underwent either a laparoscopic closed abdomen liver injury (laparoscopic 60% left-lobe hepatectomy) in an established uncontrolled severe hemorrhage model (THM), or a polytrauma hemorrhage model (PHM) involving combined liver and bowel injury, uncontrolled severe hemorrhage as well as an open full-thickness cutaneous flank wound. Read More

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http://dx.doi.org/10.1186/s12950-018-0187-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968671PMC
May 2018
8 Reads

CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients.

J Inflamm (Lond) 2018 16;15:10. Epub 2018 May 16.

1Department of Pediatrics I, University Children's Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

Background: Endothelial progenitor cell (EPC) numbers are increased in septic patients and correlate with survival. In this study, we investigated, whether surface expression of chemokine receptors and other receptors important for EPC homing is upregulated by EPC from septic patients and if this is associated with clinical outcome.

Methods: Peripheral blood mononuclear cells from septic patients ( = 30), ICU control patients ( = 11) and healthy volunteers ( = 15) were isolated by Ficoll density gradient centrifugation. Read More

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http://dx.doi.org/10.1186/s12950-018-0186-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956812PMC
May 2018
1 Read

The role of adipokines in skeletal muscle inflammation and insulin sensitivity.

J Inflamm (Lond) 2018 9;15. Epub 2018 May 9.

1MRC-ARUK Centre for Musculoskeletal Ageing Research, Medical School, Queen Elizabeth Hospital, University of Birmingham, Birmingham, B15 2WB UK.

Background: There is currently an unmet clinical need to develop better pharmacological treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end, determining the effect of obesity-associated adipokines on skeletal muscle insulin sensitivity has emerged as an important area of drug discovery research. This review draws together the data on the functional role of adipokines on skeletal muscle insulin signalling, highlights several understudied novel adipokines and provides a perspective on the direction of future research. Read More

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http://dx.doi.org/10.1186/s12950-018-0185-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944154PMC
May 2018
3 Reads

Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis.

J Inflamm (Lond) 2018 9;15. Epub 2018 May 9.

1Department of Internal Medicine, State University of Campinas, Campinas, SP Brazil.

Background: Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. The excess production of pro-inflammatory mediators also impairs insulin signaling, which may be a pathophysiological tissue marker of proinflammatory cytokine action before organ failure. Read More

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http://dx.doi.org/10.1186/s12950-018-0184-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944072PMC
May 2018
4 Reads

Functional role of microRNA-135a in colitis.

J Inflamm (Lond) 2018 6;15. Epub 2018 Apr 6.

Department of Pediatrics, Huaihe Hospital of Henan University, No. 8, Baobei Road, Gulou District, Kaifeng, 475000 China.

Background: Inflammatory bowel disease (IBD) is one of the chronic gastrointestinal diseases with increasing risk of colon cancer development in the future. Apoptosis and inflammation play an important role in the etiology of this disease. MicroRNAs are associated with etiology of different diseases including IBD. Read More

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http://dx.doi.org/10.1186/s12950-018-0181-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889596PMC
April 2018
2 Reads

Correction to: Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection.

J Inflamm (Lond) 2018 3;15. Epub 2018 Apr 3.

4Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266000 China.

[This corrects the article DOI: 10.1186/s12950-017-0162-7.]. Read More

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http://dx.doi.org/10.1186/s12950-018-0183-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883406PMC
April 2018
4 Reads

Zymosan attenuates melanoma growth progression, increases splenocyte proliferation and induces TLR-2/4 and TNF-α expression in mice.

J Inflamm (Lond) 2018 22;15. Epub 2018 Mar 22.

7Airways Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK.

Background: Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments. Toll-like receptors (TLRs) play an important role in evoking innate immunity against cancer cells. Read More

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http://dx.doi.org/10.1186/s12950-018-0182-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863857PMC
March 2018
11 Reads

Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model.

J Inflamm (Lond) 2018 27;15. Epub 2018 Feb 27.

Department of General surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian People's Republic of China.

Background: Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for its strong immunoregulatory and anti-inflammatory abilities. However, whether and how IL-10 protects the BBB in SAP are still unclear. Read More

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http://dx.doi.org/10.1186/s12950-018-0180-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828420PMC
February 2018
9 Reads

Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression.

J Inflamm (Lond) 2018 10;15. Epub 2018 Jan 10.

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 833 Taiwan.

Background: Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we developed an effective adjunct therapy mediated by a novel mechanism, to attenuate overt inflammation. LPS-treated macrophages were adopted as an in vitro model of endotoxin-induced inflammation during sepsis. Read More

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http://dx.doi.org/10.1186/s12950-018-0179-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763578PMC
January 2018
8 Reads

Anti-inflammatory cellular targets on neutrophils elucidated using a novel cell migration model and confocal microscopy: a clinical supplementation study.

J Inflamm (Lond) 2018 5;15. Epub 2018 Jan 5.

Department Physiological Sciences, Science Faculty, Stellenbosch University, Stellenbosch, South Africa.

Background: In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary damage, as well as by facilitating an early anti-inflammatory macrophage phenotype shift. The current study aimed to provide data in this context from human models and to elucidate specific molecular targets of GSP.Using a placebo-controlled, double-blind study design, eighteen normally healthy volunteers between the ages of 18-35 years old (13 female and 5 male) were orally supplemented with 140 mg/day of GSP for 2 weeks. Read More

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http://dx.doi.org/10.1186/s12950-017-0177-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756363PMC
January 2018
2 Reads

Plasma vascular non-inflammatory molecule 3 is associated with gastrointestinal acute graft-versus-host disease in mice.

J Inflamm (Lond) 2018 5;15. Epub 2018 Jan 5.

Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Nan Bai Xiang Street, Ouhai District, Wenzhou, Zhejiang 325002 China.

Background: Gastrointestinal acute graft-versus-host disease (GI aGVHD) is a lethal complication following allogeneic hematopoietic stem cell transplantation (HSCT). However, it is still very difficult to make a diagnosis of GI aGVHD in practice. To date, no consensus plasma biomarker of GI aGVHD can be used to help make a diagnosis. Read More

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http://dx.doi.org/10.1186/s12950-017-0178-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755465PMC
January 2018
11 Reads

Neutrophil extracellular traps and the dysfunctional innate immune response of cystic fibrosis lung disease: a review.

J Inflamm (Lond) 2017 28;14:29. Epub 2017 Dec 28.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ UK.

Background: Cystic Fibrosis (CF) is a devastating genetic disease characterised primarily by unrelenting lung inflammation and infection resulting in premature death and significant morbidity. Neutrophil Extracellular Traps (NETs) are possibly key to inflammation in the disease. This review aims to draw together existing research investigating NETs in the context of a dysfunctional innate immune system in CF. Read More

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http://dx.doi.org/10.1186/s12950-017-0176-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745605PMC
December 2017
12 Reads

Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy.

J Inflamm (Lond) 2017 6;14:28. Epub 2017 Dec 6.

Department of Pharmacology , Theravance Biopharma US, Inc, 901 Gateway Boulevard, South San Francisco, CA 94080 USA.

Background: An unmet need remains for safe and effective treatments to induce and maintain remission in inflammatory bowel disease (IBD) patients. The Janus kinase (JAK) inhibitor, tofacitinib, has demonstrated robust efficacy in ulcerative colitis patients although, like other systemic immunosuppressants, there may be safety concerns associated with its use. This preclinical study evaluated whether modulating intestinal inflammation via local JAK inhibition can provide efficacy without systemic immunosuppression. Read More

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http://dx.doi.org/10.1186/s12950-017-0175-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718031PMC
December 2017
44 Reads

Treatment with 24 h-delayed normo- and hyperbaric oxygenation in severe sepsis induced by cecal ligation and puncture in rats.

J Inflamm (Lond) 2017 25;14:27. Epub 2017 Nov 25.

Department of Anesthesia, Center of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

Background: Septic shock remains a leading cause of death worldwide. Hyperbaric oxygen treatment (HBO) has been shown to alter the inflammatory response during sepsis and to reduce mortality. A therapeutic window of HBO treatment has been demonstrated experimentally, but optimal timing remains uncertain. Read More

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http://dx.doi.org/10.1186/s12950-017-0173-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702232PMC
November 2017
5 Reads

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome.

J Inflamm (Lond) 2017 21;14:26. Epub 2017 Nov 21.

Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, Singapore.

Primary Sjögren's syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities of treatment. Read More

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https://journal-inflammation.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12950-017-0174-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698951PMC
November 2017
17 Reads

Hyperoside attenuates dextran sulfate sodium-induced colitis in mice possibly via activation of the Nrf2 signalling pathway.

J Inflamm (Lond) 2017 14;14:25. Epub 2017 Nov 14.

Department of Gastroenterology, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, 430060 China.

Background: Hyperoside (Hyp) is a flavonoid glycoside compound that has been demonstrated to have anti-inflammatory, anti-apoptotic and antioxidant effects. However, the impact of Hyp on inflammatory bowel disease (IBD) has not been previously explored. Thus, we evaluated the role of Hyp in dextran sodium sulfate (DSS)-induced acute colitis in mice. Read More

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http://dx.doi.org/10.1186/s12950-017-0172-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686943PMC
November 2017
14 Reads

Detection of circulating natural antibodies to inflammatory cytokines in type-2 diabetes and clinical significance.

J Inflamm (Lond) 2017 6;14:24. Epub 2017 Nov 6.

Division of Health Research, University of the Highlands & Islands, Centre for Health Science, Perth Road, Inverness, IV2 3JH UK.

Background: Inflammatory cytokines have been demonstrated to be involved in developing insulin resistance and type-2 diabetes (T2D). Natural antibodies in the circulation have protective effects on common diseases in humans. The present study was thus designed to test the hypothesis that natural antibodies against inflammatory cytokines could be associated with T2D. Read More

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http://dx.doi.org/10.1186/s12950-017-0171-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674864PMC
November 2017
11 Reads

Host responses to concurrent combined injuries in non-human primates.

J Inflamm (Lond) 2017 2;14:23. Epub 2017 Nov 2.

Department of Regenerative Medicine, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 USA.

Background: Multi-organ failure (MOF) following trauma remains a significant cause of morbidity and mortality related to a poorly understood abnormal inflammatory response. We characterized the inflammatory response in a non-human primate soft tissue injury and closed abdomen hemorrhage and sepsis model developed to assess realistic injury patterns and induce MOF.

Methods: Adult male Mauritan Cynomolgus Macaques underwent laparoscopy to create a cecal perforation and non-anatomic liver resection along with a full-thickness flank soft tissue injury. Read More

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http://dx.doi.org/10.1186/s12950-017-0170-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667447PMC
November 2017
10 Reads

LPS regulates the expression of glucocorticoid receptor α and β isoforms and induces a selective glucocorticoid resistance in vitro.

J Inflamm (Lond) 2017 16;14:22. Epub 2017 Oct 16.

Rheumatology Section, Internal Medicine Department, Clinical Hospital, University of Chile, Santiago, Chile.

Background: This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in vitro.

Methods: U-2 OS cell lines expressing GR isoforms, different cell lines (CEM, RAJI, K562 and HeLa) or PBMC from healthy donors, were cultured or not with LPS. The expression of GRα and GRβ was evaluated by Western blot. Read More

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http://journal-inflammation.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12950-017-0169-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644185PMC
October 2017
8 Reads

Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients.

J Inflamm (Lond) 2017 18;14:21. Epub 2017 Sep 18.

Department of Haematology, Uppsala University Hospital, 751 85 Uppsala, Sweden.

In this study, a competitive hepcidin ELISA assay was evaluated for its ability to differentiate between iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, using the absence of stainable bone marrow iron as the diagnostic criterion for iron deficiency. In addition, correlation coefficients for hepcidin versus C-reactive protein, ferritin and interleukin-6 were determined. The optimal cut-off for hepcidin was 21 μg/L, corresponding to sensitivity and specificity of 100% and 67%, respectively, for iron deficiency. Read More

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http://dx.doi.org/10.1186/s12950-017-0166-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604302PMC
September 2017
9 Reads

Depletion of club cells attenuates bleomycin-induced lung injury and fibrosis in mice.

J Inflamm (Lond) 2017 18;14:20. Epub 2017 Sep 18.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: The role of bronchiolar epithelial cells in the pathogenesis of pulmonary fibrosis has not been clarified. We previously demonstrated DNA damage in murine bronchioles in the early stages of bleomycin-induced pulmonary fibrosis that subsequently extended to alveolar cells at the advanced stages of the disease. Club cells are progenitor cells for bronchioles and are known to play protective roles against lung inflammation and damage. Read More

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http://dx.doi.org/10.1186/s12950-017-0168-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604393PMC
September 2017
71 Reads

Leptin independently predicts development of sepsis and its outcome.

J Inflamm (Lond) 2017 11;14:19. Epub 2017 Sep 11.

Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.

Background: Sepsis is a life-threatening condition and obesity is related to the clinical outcome. The underlying reasons are incompletely understood, but the adipocyte derived hormones leptin and adiponectin may be involved.

Methods: Patients aged 18 years or more with documented first time sepsis events were included in a nested case-referent study if they had participated in previous health surveys. Read More

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http://journal-inflammation.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12950-017-0167-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594589PMC
September 2017
6 Reads

Chronic asthma and Mesenchymal stem cells: Hyaluronan and airway remodeling.

J Inflamm (Lond) 2017 30;14:18. Epub 2017 Aug 30.

Department of Pediatrics, Case Western Reserve University, Cleveland, OH USA.

Background: Previous studies have demonstrated that ovalbumin sensitization promotes chronic asthma phenotype in murine asthma model. Human mesenchymal stem cells (hMSCs) are multipotent cells in vitro that have been shown to decrease inflammation and can reverse airway remodeling when infused into an in vivo chronic asthma model. However, the mechanism by which hMSCs reverse remodeling is still unclear. Read More

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http://dx.doi.org/10.1186/s12950-017-0165-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577750PMC
August 2017
18 Reads

Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection.

J Inflamm (Lond) 2017 9;14:17. Epub 2017 Aug 9.

Department of Neurology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Road, Qingdao, 266000 China.

Background: Intracranial infection, one of the complications of traumatic brain injury, is usually associated with inflammation. Several microRNAs (miRNAs), including miR-155, have been reported to be critical modulators in peripheral and central nervous system inflammation. In this study, we investigated the role of miR-155 in lipopolysaccharide (LPS)-induced inflammatory injury in mouse microglia BV2 cells. Read More

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http://dx.doi.org/10.1186/s12950-017-0162-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549339PMC
August 2017
10 Reads

Interleukin-35 on B cell and T cell induction and regulation.

J Inflamm (Lond) 2017 7;14:16. Epub 2017 Aug 7.

Department of Thoracic Surgery, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1277 Jiefang Avenue, Wuhan, Hubei Province 430022 People's Republic of China.

Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. Read More

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http://dx.doi.org/10.1186/s12950-017-0164-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547520PMC
August 2017
8 Reads

Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells.

J Inflamm (Lond) 2017 13;14:15. Epub 2017 Jul 13.

Inflammation Research Unit, Division of Internal Medicine, University Hospital Zürich, Rämistrasse 100, CH-8091 Zürich, Switzerland.

Wnt5A is a chemokine secreted by inflammatory-activated human macrophages that sustains their inflammatory response in an autocrine manner. High levels of Wnt5A are found in sera of patients with sepsis and septic shock. Here, we comment on recently reported Wnt5A signalling pathways in human vascular endothelial cells (VEC). Read More

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http://dx.doi.org/10.1186/s12950-017-0163-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508782PMC
July 2017
4 Reads