5,879 results match your criteria Journal of Infection[Journal]


Characterization of QuantiFERON-TB-Plus results in latent tuberculosis infected patients with or without immune-mediated inflammatory diseases.

J Infect 2019 Apr 11. Epub 2019 Apr 11.

Translational Research Unit, Department of Epidemiology and Preclinical Research, "L. Spallanzani" National Institute for Infectious Diseases (INMI), IRCCS, Via Portuense 292, 00149 Rome, Italy. Electronic address:

Objectives: Screening for latent tuberculosis infection (LTBI) diagnosis is mandatory in patients with immune-mediated inflammatory diseases (IMID) requiring biologics. QuantiFERON-TB-Plus (QFT-P), an LTBI diagnostic test, measures IFN-γ after M. tuberculosis-stimulation in TB1 and TB2 tubes in which a "CD4" or a "CD4 and CD8" response is respectively elicited. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.010DOI Listing
April 2019
8 Reads

Chronic-relapsing varicella zoster meningitis - successfully treated with varicella vaccine.

J Infect 2019 Apr 10. Epub 2019 Apr 10.

Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester; Respiratory Sciences, University of Leicester, Leicester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.04.009DOI Listing
April 2019
2 Reads

Incidence rate of depression as an adverse effect of multidrug-resistant tuberculosis treatment.

J Infect 2019 Apr 9. Epub 2019 Apr 9.

West China College of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.04.001DOI Listing
April 2019
5 Reads

Development and Internal Validation of a Model for Predicting 60-Day Risk of Invasive Mould Disease in Patients with Haematological Malignancies.

J Infect 2019 Apr 8. Epub 2019 Apr 8.

Clinic of Infectious Diseases, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. Electronic address:

Objective: Our objective was to develop a model that predicts a patient's risk of developing invasive mould disease (IMD) within 60 days of admission for treatment of a haematological malignancy.

Methods: We analysed 19 risk factors for IMD in a cohort of 1,944 adult patients with haematological malignancies over 4,127 admissions at a haematology referral centre in Northern Italy (2007-2016). We used a multivariable logistic regression to estimate the 60-day probability of developing probable or proven IMD. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.002DOI Listing
April 2019
4 Reads

Septic shock among patients with systemic lupus erythematosus: short and long-term outcome. Analysis of a French nationwide database.

J Infect 2019 Apr 8. Epub 2019 Apr 8.

APHP Medical and infectious diseases ICU Bichat hospital, F75018, Paris.

Objectives: We aimed to assess the characteristics, outcomes and costs of septic shock complicating Systemic Lupus Erythematosus (SLE).

Methods: Characteristics of SLE patients experiencing a septic shock in France from 2010 to 2015 were analyzed through the French medico-administrative database. Factors associated with the 1-year post-admission mortality were analyzed, the crude 1-year survival of SLE patients experiencing septic shock was compared to those admitted for another reason, and we compared the 1-year outcome associated with SLE septic shock survival to a matched SLE ICU control population. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.005DOI Listing
April 2019
5 Reads

SV40 seroprevalence in two Latin American countries involved in field trials of candidate oral poliovaccines.

J Infect 2019 Apr 6. Epub 2019 Apr 6.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Objectives: This study sought to determine SV40 seroprevalence in residents of two Latin American countries, Colombia and Nicaragua, which were sites of prelicensure oral poliovaccine (OPV) trials.

Methods: Archival sera were tested for SV40 neutralizing antibody using a virus-specific plaque-reduction assay. Samples included 517 sera from Colombia and 149 sera from Nicaragua. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.007DOI Listing
April 2019
4.441 Impact Factor

Treatment stratification of respiratory syncytial virus infection in allogeneic stem cell transplantation.

J Infect 2019 Apr 6. Epub 2019 Apr 6.

Department of Clinical Haematology, Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK.

Background: Due to paucity of evidence to guide management of allogeneic haematopoietic stem cell transplantation (allo-HSCT) patients with respiratory syncytial virus (RSV) infections national and international guidelines make disparate recommendations.

Methods: The outcomes of allo-HSCT recipients with RSV infection between 2015 and 2017 were assessed using the following treatment stratification; upper respiratory tract infections (URTI) being actively monitored and lower respiratory tract infections (LRTI) treated with short courses of oral ribavirin combined with intravenous immunoglobulin (IVIG, 2 g/kg).

Results: During the study period 49 RSV episodes were diagnosed (47% URTI and 53% LRTI). Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.004DOI Listing
April 2019
2 Reads

Synovial C-reactive protein features high negative predictive value but is not useful as a single diagnostic parameter in suspected periprosthetic joint infection (PJI).

J Infect 2019 Apr 6. Epub 2019 Apr 6.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Objectives: Synovial fluid C-reactive protein (syCRP) has been recently described as a new biomarker in preoperative diagnostics to identify periprosthetic joint infections (PJI). The aim of this study was to evaluate syCRP in a large cohort of patients with suspected PJI and to calculate the optimal cut-off to diagnose PJI.

Methods: Between September 2015 and June 2017, we prospectively included patients with suspected PJI, in which syCRP was additionally measured along with routine preoperative diagnostic serum and synovial biomarkers. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.003DOI Listing

Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality.

J Infect 2019 Apr 6. Epub 2019 Apr 6.

Center for Biomedical Research Network in Respiratory Diseases (CIBERES, CB06/06/0028), Madrid, Spain; Pneumology Department, Hospital Clínic / Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Objectives: Lymphopenic (<724 lymphocytes/µL) community-acquired pneumonia (L-CAP) is an immunophenotype with an increased risk of mortality. We aimed to characterize the l-CAP immunophenotype though lymphocyte subsets and the inflammatory response and its relationship with severity at presentation and outcome.

Methods: Prospective study of 217 immunocompetent patients hospitalized for CAP. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.04.006DOI Listing
April 2019
1 Read

Community based serosurvey of naïve population indicate no local circulation of Zika virus in an hyper endemic area of China 2016.

J Infect 2019 Apr 1. Epub 2019 Apr 1.

Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China; WHO Collaborating Centre for Surveillance, Research and Training of Emerging Infectious Diseases, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.03.013DOI Listing

Antibiotic resistance gene reservoir in live poultry markets.

J Infect 2019 Mar 30. Epub 2019 Mar 30.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Beijing Key Laboratory of Antimicrobial Resistance and Pathogen Genomics, Beijing 100101, China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases First Attainted Hospital, College of Medicine, Zhejiang University, 310006, China; Department of Pathogenic Biology, School of Basic Medical Sciences, Southwest Medical University, Sichuan 646000, China. Electronic address:

Objectives: The heavy use of antibiotics in farm animals contributes to the enrichment and spread of antibiotic resistance genes (ARGs) in "one-health" settings. Numerous ARGs have been identified in livestock-associated environments but not in Chinese live poultry markets (LPMs).

Methods: We collected 753 poultry fecal samples from LPMs of 18 provinces and municipalities in China and sequenced the metagenomes of 130 samples. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.03.012DOI Listing
March 2019
1 Read

Characterization of three clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated from wild birds.

J Infect 2019 Mar 27. Epub 2019 Mar 27.

Guangdong Institute of Applied Biological Resources, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.03.011DOI Listing
March 2019
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A randomised controlled trial of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDITOF-MS) versus conventional microbiological methods for identifying pathogens: Impact on optimal antimicrobial therapy of invasive bacterial and fungal infections in Vietnam.

J Infect 2019 Mar 23. Epub 2019 Mar 23.

Centre for Tropical Medicine & Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Department of Medical Microbiology, RadboudUMC, Nijmegen, The Netherlands.

Objectives: We assessed the impact of MALDITOF-MS on the timeliness of optimal antimicrobial therapy through a parallel-arm randomised controlled trial in two hospitals in Vietnam.

Methods: We recruited patients with a pathogen (bacterial or fungal) cultured from a normally sterile sample. Samples were randomly assigned (1:1) to identification by MALDITOF-MS or conventional diagnostics. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.03.010DOI Listing
March 2019
1 Read
4.441 Impact Factor

Rapid evolution and gene communication of H3N2 and H1N1 influenza a viruses.

J Infect 2019 Mar 23. Epub 2019 Mar 23.

National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, College of Veterinary Medicine, South China Agricultural University, China; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.03.009DOI Listing

Human-isolated H7N9 obtained internal genes from duck and human influenza viruses.

J Infect 2019 Mar 14. Epub 2019 Mar 14.

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510642, China; Shantou University Medical College, Shantou 515041, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.03.008DOI Listing

Poor transmission of seasonal cold viruses in a British Antarctic Survey base.

J Infect 2019 Mar 14. Epub 2019 Mar 14.

Department of Microbiology, Derriford Hospital, Plymouth Hospitals NHS Trust, Plymouth, UK; Respiratory Sciences, University of Leicester, Leicester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.03.007DOI Listing

First experience of ribavirin postexposure prophylaxis for Nipah virus, tried during the 2018 outbreak in Kerala, India.

J Infect 2019 Mar 6. Epub 2019 Mar 6.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.03.005DOI Listing
March 2019
4.441 Impact Factor

Discovery of a potential MCR-1 inhibitor that reverses polymyxin activity against clinical mcr-1-positive Enterobacteriaceae.

J Infect 2019 Mar 6. Epub 2019 Mar 6.

Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China. Electronic address:

The recent emergence of the plasmid-mediated colistin resistance gene mcr-1 poses a substantial clinical threat to the severe infections caused by CRE (Carbapenem Resistant Enterobacteriaceae), as the treatment failure of the mcr-1-positive CRE "Superbug" most likely occurs by using the combination of carbapenem and polymixins. Therefore, our study aims to seek a potent MCR-1 inhibitor to fight this infection. A checkerboard MIC (Minimum Inhibitory Concentration) assay, time-killing assay, MPNP (Modified rapid polymyxin Nordmann/Poirel) test, combined disk test and molecular modelling analysis were performed on different mcr-1-positive strains to confirm the synergistic effects of the combination of colistin and osthole (OST). Read More

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http://dx.doi.org/10.1016/j.jinf.2019.03.004DOI Listing
March 2019
2 Reads

Precision medicine in resistant Tuberculosis: Treat the correct patient, at the correct time, with the correct drug.

J Infect 2019 Apr 6;78(4):261-268. Epub 2019 Mar 6.

CAPRISA, Centre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Private Bag X7, Congella, 4013, Durban, South Africa. Electronic address:

Human genomic mapping has advanced molecular medicine health care and created a transformative paradigm shift towards Precision Medicine. In 2015, President Obama launched the PM initiative, encapsulated as "unique individualized data-driven treatments". Since then, this field is rapidly advancing both curative treatment and disease prevention by accounting for both individual and environmental variability. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.03.006DOI Listing
April 2019
1 Read
4.441 Impact Factor

Managing monkey bites in returning travellers.

J Infect 2019 Mar 5. Epub 2019 Mar 5.

Clinical Microbiology, University Hospitals of Leicester NHS Trust, Level 5 Sandringham Building, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK; Department of Respiratory Sciences, University of Leicester, Leicester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.03.002DOI Listing
March 2019
1 Read

Longer-term effectiveness of protease-inhibitor-based second line antiretroviral therapy in four large sub-Saharan African clinics.

J Infect 2019 Mar 6. Epub 2019 Mar 6.

University of Siena, Siena, Italy.

Objectives: Data on the longer-term effectiveness of second line combination antiretroviral therapy (ART) in sub-Saharan Africa (SSA) are lacking. We sought to assess the probability and determinants of 2nd line ART failure in SSA.

Methods: A retrospective, multi-center study of 2nd line ART initiated between 2005 and 2017 at four ART centers in Ethiopia, Ghana and Uganda. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.03.003DOI Listing

The Dengue Outbreak of 2014 Transformed the Epidemic Characteristics of Dengue in Guangdong Province, China.

J Infect 2019 Mar 5. Epub 2019 Mar 5.

Center for Disease Control and Prevention of Chinese People's Liberation Army, 20 Dongdajie Street, Fengtai District, Beijing 100071, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193007
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http://dx.doi.org/10.1016/j.jinf.2019.03.001DOI Listing
March 2019
7 Reads

Failure of metagenomics in detecting emerging pathogens, the Clostridium difficile paradigm.

J Infect 2019 Mar 4. Epub 2019 Mar 4.

Aix Marseille Univ, IRD, MEPHI, IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005 Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.02.014DOI Listing

Subtherapeutic posaconazole troughs despite high-dose posaconazole tablets in a patient with terminal ileum resection.

J Infect 2019 Feb 27. Epub 2019 Feb 27.

Department of Pharmacy, Singapore General Hospital, Outram Road, Singapore 169608, Singapore; Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; Singhealth Duke-NUS Medicine Academic Clinical Programme, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193006
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http://dx.doi.org/10.1016/j.jinf.2019.02.013DOI Listing
February 2019
3 Reads

Burden of hospital admissions caused by respiratory syncytial virus (RSV) in infants in England: A data linkage modelling study.

J Infect 2019 Feb 26. Epub 2019 Feb 26.

Respiratory Diseases Department, Public Health England, Colindale, London, UK.

Objectives: Current national estimates of respiratory syncytial virus (RSV)-associated hospital admissions are insufficiently detailed to determine optimal vaccination strategies for RSV. We employ novel methodology to estimate the burden of RSV-associated hospital admissions in infants in England, with detailed stratification by patient and clinical characteristics.

Methods: We used linked, routinely collected laboratory and hospital data to identify laboratory-confirmed RSV-positive and RSV-negative respiratory hospital admissions in infants in England, then generate a predictive logistic regression model for RSV-associated admissions. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.012DOI Listing
February 2019
3 Reads

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis.

J Infect 2019 Feb 22. Epub 2019 Feb 22.

Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Edinburgh, UK; Intensive Care Unit, Royal Infirmary Edinburgh, Edinburgh, UK.

Objectives: To assess the utility of the neutrophil:lymphocyte (NLR), lymphocyte:monocyte (LMR) and platelet:lymphocyte ratios (PLR) as infection biomarkers.

Methods: PubMed/MEDLINE, Embase and Cochrane databases were searched to identify eligible articles. Studies of diagnosis, severity or outcome were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193005
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http://dx.doi.org/10.1016/j.jinf.2019.02.006DOI Listing
February 2019
7 Reads

Next-generation sequencing combined with routine methods to detect the pathogens of encephalitis/meningitis from a Chinese tertiary pediatric neurology center.

J Infect 2019 Feb 22. Epub 2019 Feb 22.

Department of Neurology, Children's Hospital Affiliated Capital Institute of Pediatrics, Beijing 100020, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.02.011DOI Listing
February 2019
2 Reads

Use of enteral amikacin to eliminate carriership with multidrug resistant Enterobacteriaceae.

J Infect 2019 Feb 22. Epub 2019 Feb 22.

Department of Intensive Care Medicine, OLVG Hospital, P.O. Box 95500, 1090HM Amsterdam, the Netherlands; TIAS School for Business and Society, Tilburg University, Warandelaan 2, 5037AB, Tilburg, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.02.007DOI Listing
February 2019

Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia.

J Infect 2019 Feb 21. Epub 2019 Feb 21.

Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain; Department of Microbiology, School of Medicine, University of Valencia, Av. Blasco Ibáñez 17, 46010 Valencia, Spain. Electronic address:

Objectives: To date no definitive cut-off value for cytomegalovirus (CMV) DNA load in bronchoalveolar lavage (BAL) fluid specimens has been established to discriminate between CMV pneumonia and pulmonary CMV DNA shedding in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients.

Methods: The current retrospective study is aimed at assessing the range of CMV DNA loads quantified in BAL fluid specimens from allo-HSCT patients with pneumonia in which different microorganisms were causally involved.

Results: A total of 144 BAL specimens from 123 patients were included. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.009DOI Listing
February 2019
7 Reads

Xpert MTB/RIF Ultra improved the diagnosis of paucibacillary tuberculosis: A prospective cohort study.

J Infect 2019 Apr 21;78(4):311-316. Epub 2019 Feb 21.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beiguan St #9, Beijing, China. Electronic address:

Objectives: We assessed the diagnostic performance of Xpert MTB/RIF Ultra (Xpert Ultra) in comparison to Xpert MTB/RIF (Xpert) for the detection of paucibacillary tuberculosis (TB).

Methods: Smear-negative sputum, pleural fluid and cerebrospinal fluid (CSF) were collected from TB suspects at Beijing Chest Hospital (Beijing, China) and were examined using smear, Xpert and culture. Xpert Ultra was tested using specimens stored at -80 °C. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.010DOI Listing

Identification of two new core chromosome-encoded superantigens in Streptococcus pyogenes; speQ and speR.

J Infect 2019 Feb 20. Epub 2019 Feb 20.

Department of Infectious Diseases, Imperial College London, London W12 0NN, UK; Department of Molecular Biology & Biotechnology, The Florey Institute, University of Sheffield, Sheffield S10 2TN, UK. Electronic address:

Superantigens are ubiquitous within the Streptococcus pyogenes genome, which suggests that superantigen-mediated T-cell activation provides a significant selective advantage. S. pyogenes can carry a variable complement of the 11 known superantigens. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.005DOI Listing
February 2019

Six amino acids of VP1 switch along with pandemic of CV-A6-associated HFMD in Guangxi, southern China, 2010-2017.

J Infect 2019 Apr 14;78(4):323-337. Epub 2019 Feb 14.

Institute of Acute Infectious Diseases Control and Prevention, Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Jinzhou Road 18, Nanning 530028, Guangxi, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.02.002DOI Listing
April 2019
1 Read

Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.

J Infect 2019 Feb 8. Epub 2019 Feb 8.

Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.

Objectives: Respiratory syncytial virus (RSV) causes respiratory infection across the world, with infants and the elderly at particular risk of developing severe disease and death. The replication-defective chimpanzee adenovirus (PanAd3-RSV) and modified vaccinia virus Ankara (MVA-RSV) vaccines were shown to be safe and immunogenic in young healthy adults. Here we report an extension to this first-in-man vaccine trial to include healthy older adults aged 60-75 years. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.003DOI Listing
February 2019
5 Reads

Neurosurgical device-associated infections due to Candida auris - Three cases from a single tertiary center.

J Infect 2019 Feb 10. Epub 2019 Feb 10.

Oxford University Hospitals NHS Foundation Trust, United Kingdom.

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http://dx.doi.org/10.1016/j.jinf.2019.02.004DOI Listing
February 2019

A case-control study into risk factors for acute hepatitis E in the Netherlands, 2015-2017.

J Infect 2019 Feb 8. Epub 2019 Feb 8.

Epidemiology and surveillance unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven, The Netherlands. Electronic address:

Objectives: A case-control study was performed (2015-2017) to identify risk factors for acute hepatitis E in the Netherlands.

Methods: A questionnaire on potential sources of hepatitis E virus (HEV) exposure, health and socio-demographics was completed by 376 patients with acute hepatitis E, and 1534 controls matched for age, gender and region of residence.

Results: Traditional Dutch dry raw sausages of pork muscle meat, called "cervelaat", "snijworst", and "boerenmetworst" were reported by 72% of the patients, and 46% of controls (aOR 3. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.001DOI Listing
February 2019
2 Reads

Serial testing of Mycobacterium tuberculosis infection in Chinese village doctors by QuantiFERON-TB Gold Plus, QuantiFERON-TB Gold in-Tube and T-SPOT.TB.

J Infect 2019 Apr 30;78(4):305-310. Epub 2019 Jan 30.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China. Electronic address:

Objectives: To evaluate the performance of QuantiFERON-TB Gold Plus (QFT-Plus) on Mycobacterium tuberculosis (MTB) infection test among registered village doctors from China.

Methods: MTB infection of the registered village doctors in Zhongmu County were tested using QFT-Plus and two other interferon-gamma release assays (IGRAs) in parallel: QuantiFERON-TB Gold In-Tube (QFT) and T-SPOT.TB (T-SPOT). Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.008DOI Listing
April 2019
1 Read

Continuous adaptation of the HA and NA gene of H3N2 subtypes of avian influenza virus in South China, 2017-2018.

J Infect 2019 Jan 30. Epub 2019 Jan 30.

National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, College of Veterinary Medicine, South China Agricultural University; Key Laboratory of Zoonoses, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture, Guangzhou, China; Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.01.009DOI Listing
January 2019
2 Reads

CD8 response measured by QuantiFERON-TB Gold Plus and tuberculosis disease status.

J Infect 2019 Apr 30;78(4):299-304. Epub 2019 Jan 30.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: Clinical application of the CD8 response as measured by the newer interferon gamma release assay, QuantiFERON-TB Gold-Plus (QFT-Plus), remains to be investigated.

Method: We performed this prospective study and recruited active TB patients, contacts with latent tuberculosis infection (LTBI) and contacts without LTBI in two centres in northern Taiwan in 2017. Subjects were tested with both QuantiFERON-TB Gold In-Tube (QFT-GIT) and QFT-Plus. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.007DOI Listing
April 2019
1 Read
4.441 Impact Factor

Cytokine profiles in patients with Q fever fatigue syndrome.

J Infect 2019 Jan 23. Epub 2019 Jan 23.

Radboud Expertise Center for Q Fever, Department of Internal Medicine, Division of Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Department of Internal Medicine, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address:

Background: Q fever fatigue syndrome (QFS) is a state of prolonged fatigue following around 20% of acute Q fever cases. It is thought that chronic inflammation plays a role in its etiology. To test this hypothesis we measured circulating cytokines and the ex-vivo cytokine production in patients with QFS and compared with various control groups. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.006DOI Listing
January 2019
1 Read

Comparison between human infections caused by highly and low pathogenic H7N9 avian influenza viruses in Wave Five: Clinical and virological findings.

J Infect 2019 Mar 18;78(3):241-248. Epub 2019 Jan 18.

Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen 518112, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China; University of Chinese Academy of Sciences Medical School, Chinese Academy of Sciences, Beijing 101408, China. Electronic address:

Objective: The newly emerged highly pathogenic (HP) H7N9 avian influenza virus during Wave Five has caused 28 human infections, while differences in disease severity between low pathogenic (LP)- and HP-H7N9 human infections remain unclear.

Methods: Clinical data, concentrations of serum cytokines, dynamics of virus shedding and PaO/FiO from patients infected with LP-H7N9 (n = 7, LP group) and HP-H7N9 (n = 5, HP group) viruses during Wave Five were compared. In addition, critical mutations associated with H7N9 virulence in mammal/human were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193002
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http://dx.doi.org/10.1016/j.jinf.2019.01.005DOI Listing
March 2019
6 Reads
4.441 Impact Factor

Evaluation of next-generation sequencing for the pathogenic diagnosis of children brain abscesses.

J Infect 2019 Apr 16;78(4):323-337. Epub 2019 Jan 16.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nan Lishi Road, Beijing 100045, China. Electronic address:

In this study, we applied metagenomic next-generation sequencing (mNGS) to detect the causative pathogens in brain abscess samples from 4 pediatric patients. NGS could offer unbiased sequencing and rapid diagnosis of causative pathogens, moreover, it could detect multiple pathogenic microorganisms from abscess samples. In our study, Fusobacterium nucleatum, and Streptococcus intermedius or combinations of them were found in 3/4 of polymicrobial brain abscesses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193000
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http://dx.doi.org/10.1016/j.jinf.2019.01.003DOI Listing
April 2019
8 Reads

Hepatitis E virus genotype 3 and capsid protein in the blood and urine of immunocompromised patients.

J Infect 2019 Mar 17;78(3):232-240. Epub 2019 Jan 17.

Inserm UMR1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France; Laboratory of Virology, CHU Purpan, Toulouse, France; Université Paul Sabatier, Toulouse, France. Electronic address:

Objectives: Hepatitis E virus genotype 3 (HEV3) is responsible for acute and chronic liver disease in solid organ transplant (SOT) recipients. HEV was recently found in the urine of some acutely and chronically genotype 4-infected patients.

Methods: We examined the urinary excretion of HEV3 by 24 consecutive SOT recipients at the acute phase of HEV hepatitis and characterized the excreted virus. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.004DOI Listing
March 2019
3 Reads

Vertically acquired occult hepatitis B virus infection may become overt after several years.

J Infect 2019 Mar 16;78(3):226-231. Epub 2019 Jan 16.

Department of Infectious Diseases, University of Gothenburg, 413 46 Gothenburg, Sweden. Electronic address:

Objectives: To study the frequency of vertically acquired occult hepatitis B virus (HBV) infection (OBI).

Methods: We investigated 44 children born to hepatitis B surface antigen (HBsAg) positive mothers. They received HBV vaccine directly after birth and at 2, 6 and 52 weeks of age; eight with HBeAg-positive mothers also received hepatitis B immunoglobulin (HBIG). Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.002DOI Listing
March 2019
3 Reads

Decrease of methicillin resistance in Staphylococcus aureus in nosocomial infections in Germany-a prospective analysis over 10 years.

J Infect 2019 Mar 15;78(3):215-219. Epub 2019 Jan 15.

Institute of Hygiene and Environmental Medicine, Charité - University Medicine Berlin, Hindenburgdamm 27, 12203 Berlin, Germany; German National Reference Centre for Surveillance of Nosocomial Infections, Hindenburgdamm 27, 12203 Berlin, Germany.

Objectives: Methicillin resistant Staphylococcus aureus (MRSA) remains an important cause of healthcare-associated infections. Here, we describe the development of methicillin-resistant isolates among nosocomial Staphylococcus aureus (SA) infections in Germany between 2007 and 2016.

Methods: We analyzed data from the voluntary German national nosocomial Infection Surveillance System. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193000
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http://dx.doi.org/10.1016/j.jinf.2018.12.005DOI Listing
March 2019
12 Reads

Diagnosing urinary tract infection in older people.

J Infect 2019 Apr 16;78(4):323-337. Epub 2019 Jan 16.

Northumbria Healthcare NHS Foundation Trust, Elderly Medicine, Rake Lane, North Shields, Tyne and Wear NE29 8NH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.01.001DOI Listing
April 2019
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Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage.

J Infect 2019 Mar 15;78(3):178-186. Epub 2019 Jan 15.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Objectives: Sepsis is an overwhelming systemic inflammatory response for which no satisfactory therapeutic drug is available. Previous studies have shown that autophagy is involved in the cytokine storm and vascular leakage that occur during sepsis. Therefore, we aimed to evaluate the therapeutic potential of autophagy inhibitors against bacterial infection-induced sepsis. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.12.003DOI Listing
March 2019
3 Reads

Public health outcome of Tuberculosis Cluster Investigations, England 2010-2013.

J Infect 2019 Apr 15;78(4):269-274. Epub 2019 Jan 15.

Health Protection Services, Public Health England, London, UK.

Objectives: Tuberculosis (TB) is a serious re-emergent public health problem in the UK. In response to rising case incidence a National TB Strain-Typing Service based on molecular strain-typing was established. This facilitates early detection and investigation of clusters, targeted public health action, and prevention of further transmission. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.12.004DOI Listing
April 2019
2 Reads

The clinical significance of thrombocytopenia complicating sepsis: A meta-analysis.

J Infect 2019 Apr 7;78(4):323-337. Epub 2019 Jan 7.

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 New Songjiang Road, Songjiang, Shanghai, 201600, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.12.002DOI Listing
April 2019
3 Reads

Detection of pediatric bacterial meningitis pathogens from cerebrospinal fluid by next-generation sequencing technology.

J Infect 2019 Apr 12;78(4):323-337. Epub 2018 Dec 12.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nan Lishi Road, Beijing 100045, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.12.001DOI Listing
April 2019
3 Reads