5,847 results match your criteria Journal of Infection[Journal]


Six amino acids of VP1 switch along with pandemic of CV-A6-associated HFMD in Guangxi, southern China, 2010-2017.

J Infect 2019 Feb 13. Epub 2019 Feb 13.

Institute of Acute Infectious Diseases Control and Prevention, Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning, Guangxi, China. Electronic address:

CV-A6 was observed to be the dominant pathogen for hand, foot, and mouth disease (HFMD) in autumn in Guangxi, southern China, with six amino acid switches in VP1 during 2010-2017. Our data highlights that CV-A6 is emerging to be a pivotal pathogen for HFMD in southern China. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.002DOI Listing
February 2019
1 Read

Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.

J Infect 2019 Feb 8. Epub 2019 Feb 8.

Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.

Objectives: Respiratory syncytial virus (RSV) causes respiratory infection across the world, with infants and the elderly at particular risk of developing severe disease and death. The replication-defective chimpanzee adenovirus (PanAd3-RSV) and modified vaccinia virus Ankara (MVA-RSV) vaccines were shown to be safe and immunogenic in young healthy adults. Here we report an extension to this first-in-man vaccine trial to include healthy older adults aged 60-75 years. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.003DOI Listing
February 2019
1 Read

Neurosurgical device-associated infections due to Candida auris - Three cases from a single tertiary center.

J Infect 2019 Feb 10. Epub 2019 Feb 10.

Oxford University Hospitals NHS Foundation Trust, United Kingdom.

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http://dx.doi.org/10.1016/j.jinf.2019.02.004DOI Listing
February 2019

A case-control study into risk factors for acute hepatitis E in the Netherlands, 2015-2017.

J Infect 2019 Feb 7. Epub 2019 Feb 7.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address:

Objectives: A case-control study was performed (2015-2017) to identify risk factors for acute hepatitis E in the Netherlands.

Methods: A questionnaire on potential sources of hepatitis E virus (HEV) exposure, health and socio-demographics was completed by 376 patients with acute hepatitis E, and 1534 controls matched for age, gender and region of residence.

Results: Traditional Dutch dry raw sausages of pork muscle meat, called "cervelaat", "snijworst", and "boerenmetworst" were reported by 72% of the patients, and 46% of controls (aOR 3. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.001DOI Listing
February 2019
1 Read

Serial testing of Mycobacterium tuberculosis infection in Chinese village doctors by QuantiFERON-TB Gold Plus, QuantiFERON-TB Gold in-Tube and T-SPOT.TB.

J Infect 2019 Jan 30. Epub 2019 Jan 30.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China. Electronic address:

Objectives: To evaluate the performance of QuantiFERON-TB Gold Plus (QFT-Plus) on Mycobacterium tuberculosis (MTB) infection test among registered village doctors from China.

Methods: MTB infection of the registered village doctors in Zhongmu County were tested using QFT-Plus and two other interferon-gamma release assays (IGRAs) in parallel: QuantiFERON-TB Gold In-Tube (QFT) and T-SPOT.TB (T-SPOT). Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.008DOI Listing
January 2019
1 Read

Continuous adaptation of the HA and NA gene of H3N2 subtypes of avian influenza virus in South China, 2017-2018.

J Infect 2019 Jan 30. Epub 2019 Jan 30.

National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, College of Veterinary Medicine, South China Agricultural University; Key Laboratory of Zoonoses, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture, Guangzhou, China; Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.01.009DOI Listing
January 2019
1 Read

CD8 response measured by QuantiFERON-TB Gold Plus and tuberculosis disease status.

J Infect 2019 Jan 30. Epub 2019 Jan 30.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: Clinical application of the CD8 response as measured by the newer interferon gamma release assay, QuantiFERON-TB Gold-Plus (QFT-Plus), remains to be investigated.

Method: We performed this prospective study and recruited active TB patients, contacts with latent tuberculosis infection (LTBI) and contacts without LTBI in two centres in northern Taiwan in 2017. Subjects were tested with both QuantiFERON-TB Gold In-Tube (QFT-GIT) and QFT-Plus. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.007DOI Listing
January 2019
1 Read
4.441 Impact Factor

Cytokine profiles in patients with Q fever fatigue syndrome.

J Infect 2019 Jan 23. Epub 2019 Jan 23.

Radboud Expertise Center for Q Fever, Department of Internal Medicine, Division of Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Department of Internal Medicine, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address:

Background: Q fever fatigue syndrome (QFS) is a state of prolonged fatigue following around 20% of acute Q fever cases. It is thought that chronic inflammation plays a role in its etiology. To test this hypothesis we measured circulating cytokines and the ex-vivo cytokine production in patients with QFS and compared with various control groups. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.006DOI Listing
January 2019
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Comparison between human infections caused by highly and low pathogenic H7N9 avian influenza viruses in Wave Five: Clinical and virological findings.

J Infect 2019 Jan 18. Epub 2019 Jan 18.

Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen 518112, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China; University of Chinese Academy of Sciences Medical School, Chinese Academy of Sciences, Beijing 101408, China. Electronic address:

Objective: The newly emerged highly pathogenic (HP) H7N9 avian influenza virus during Wave Five has caused 28 human infections, while differences in disease severity between low pathogenic (LP)- and HP-H7N9 human infections remain unclear.

Methods: Clinical data, concentrations of serum cytokines, dynamics of virus shedding and PaO/FiO from patients infected with LP-H7N9 (n = 7, LP group) and HP-H7N9 (n = 5, HP group) viruses during Wave Five were compared. In addition, critical mutations associated with H7N9 virulence in mammal/human were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193002
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http://dx.doi.org/10.1016/j.jinf.2019.01.005DOI Listing
January 2019
5 Reads
4.441 Impact Factor

Evaluation of next-generation sequencing for the pathogenic diagnosis of children brain abscesses.

J Infect 2019 Jan 16. Epub 2019 Jan 16.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nan Lishi Road, Beijing 100045, China. Electronic address:

In this study, we applied metagenomic next-generation sequencing (mNGS) to detect the causative pathogens in brain abscess samples from 4 pediatric patients. NGS could offer unbiased sequencing and rapid diagnosis of causative pathogens, moreover, it could detect multiple pathogenic microorganisms from abscess samples. In our study, Fusobacterium nucleatum, and Streptococcus intermedius or combinations of them were found in 3/4 of polymicrobial brain abscesses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193000
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http://dx.doi.org/10.1016/j.jinf.2019.01.003DOI Listing
January 2019
5 Reads

Hepatitis E virus genotype 3 and capsid protein in the blood and urine of immunocompromised patients.

J Infect 2019 Jan 17. Epub 2019 Jan 17.

Inserm UMR1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France; Laboratory of Virology, CHU Purpan, Toulouse, France; Université Paul Sabatier, Toulouse, France. Electronic address:

Objectives: Hepatitis E virus genotype 3 (HEV3) is responsible for acute and chronic liver disease in solid organ transplant (SOT) recipients. HEV was recently found in the urine of some acutely and chronically genotype 4-infected patients.

Methods: We examined the urinary excretion of HEV3 by 24 consecutive SOT recipients at the acute phase of HEV hepatitis and characterized the excreted virus. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.004DOI Listing
January 2019
2 Reads

Vertically acquired occult hepatitis B virus infection may become overt after several years.

J Infect 2019 Jan 16. Epub 2019 Jan 16.

Department of Infectious Diseases, University of Gothenburg, 413 46 Gothenburg, Sweden. Electronic address:

Objectives: To study the frequency of vertically acquired occult hepatitis B virus (HBV) infection (OBI).

Methods: We investigated 44 children born to hepatitis B surface antigen (HBsAg) positive mothers. They received HBV vaccine directly after birth and at 2, 6 and 52 weeks of age; eight with HBeAg-positive mothers also received hepatitis B immunoglobulin (HBIG). Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.002DOI Listing
January 2019
1 Read

Decrease of methicillin resistance in Staphylococcus aureus in nosocomial infections in Germany-a prospective analysis over 10 years.

J Infect 2019 Jan 15. Epub 2019 Jan 15.

Institute of Hygiene and Environmental Medicine, Charité - University Medicine Berlin, Hindenburgdamm 27, 12203 Berlin, Germany; German National Reference Centre for Surveillance of Nosocomial Infections, Hindenburgdamm 27, 12203 Berlin, Germany.

Objectives: Methicillin resistant Staphylococcus aureus (MRSA) remains an important cause of healthcare-associated infections. Here, we describe the development of methicillin-resistant isolates among nosocomial Staphylococcus aureus (SA) infections in Germany between 2007 and 2016.

Methods: We analyzed data from the voluntary German national nosocomial Infection Surveillance System. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193000
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http://dx.doi.org/10.1016/j.jinf.2018.12.005DOI Listing
January 2019
5 Reads

Diagnosing urinary tract infection in older people.

J Infect 2019 Jan 16. Epub 2019 Jan 16.

Northumbria Healthcare NHS Foundation Trust, Elderly Medicine, Rake Lane, North Shields, Tyne and Wear NE29 8NH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2019.01.001DOI Listing
January 2019

Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage.

J Infect 2019 Jan 15. Epub 2019 Jan 15.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Objectives: Sepsis is an overwhelming systemic inflammatory response for which no satisfactory therapeutic drug is available. Previous studies have shown that autophagy is involved in the cytokine storm and vascular leakage that occur during sepsis. Therefore, we aimed to evaluate the therapeutic potential of autophagy inhibitors against bacterial infection-induced sepsis. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.12.003DOI Listing
January 2019
1 Read

Public health outcome of Tuberculosis Cluster Investigations, England 2010-2013.

J Infect 2019 Jan 15. Epub 2019 Jan 15.

Health Protection Services, Public Health England, London, UK.

Objectives: Tuberculosis (TB) is a serious re-emergent public health problem in the UK. In response to rising case incidence a National TB Strain-Typing Service based on molecular strain-typing was established. This facilitates early detection and investigation of clusters, targeted public health action, and prevention of further transmission. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.12.004DOI Listing
January 2019
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The clinical significance of thrombocytopenia complicating sepsis: A meta-analysis.

J Infect 2019 Jan 7. Epub 2019 Jan 7.

Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 New Songjiang Road, Songjiang, Shanghai, 201600, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.12.002DOI Listing
January 2019
1 Read

Detection of pediatric bacterial meningitis pathogens from cerebrospinal fluid by next-generation sequencing technology.

J Infect 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nan Lishi Road, Beijing 100045, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.12.001DOI Listing
December 2018

Mortality risk factors for listeriosis - A 10 year review of non-pregnancy associated cases in England 2006-2015.

J Infect 2018 Dec 5. Epub 2018 Dec 5.

Reference Microbiology Services, National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United Kingdom; Gastrointestinal Infections Department, National Infection Service, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United Kingdom. Electronic address:

LISTERIOSIS: is a foodborne illness that can result in septicaemia, Central Nervous System (CNS) disease, foetal loss and death in high risk patients.

Objectives: To analyse the demographic trends, clinical features and treatment of non-perinatal listeriosis cases over a ten year period and identify mortality-associated risk factors.

Methods: Reported laboratory-confirmed non-pregnancy associated cases of listeriosis between 2006 and 2015 in England were included and retrospectively analysed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453183035
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http://dx.doi.org/10.1016/j.jinf.2018.11.007DOI Listing
December 2018
2 Reads

Differential T cell responses against DosR-associated antigen Rv2028c in BCG-vaccinated populations with tuberculosis infection.

J Infect 2018 Dec 5. Epub 2018 Dec 5.

School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, China; Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, 2901 Caolang Rd., Shanghai 201508, China; School of Laboratory Medicine and Life Science, Jinlin Agriculture University, Changchun 130033, China. Electronic address:

The IFN-γ release assays (IGRAs) based on region of difference 1 (RD1) antigens have improved diagnosis of Mycobacterium tuberculosis (Mtb) infection. However, IGRAs with these antigens could not distinguish latent tuberculosis infection (LTBI) from active tuberculosis (ATB). DosR regulon genes are thought to be important for Mtb dormancy, and their products have higher immunogenicity in LTBI than ATB individuals, suggesting protective immunity mediated by DosR regulon-encoded antigens and potential utility of them for differential diagnostics of Mtb-infected populations or development of therapeutic vaccines against tuberculosis (TB). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453183035
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http://dx.doi.org/10.1016/j.jinf.2018.10.016DOI Listing
December 2018
5 Reads

Severe periodontitis is more common in HIV- infected patients.

J Infect 2018 Dec 6. Epub 2018 Dec 6.

Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address:

Objective: To assess periodontitis prevalence and severity in HIV infected patients as compared to controls. Furthermore, to assess whether HIV infection characteristics are associated with periodontitis.

Design: cross-sectional controlled study. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.11.008DOI Listing
December 2018

Diagnostic performance of plasma cytokine biosignature combination and MCP-1 as individual biomarkers for differentiating stages Mycobacterium tuberculosis infection.

J Infect 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Laboratory, Institute of Surgery Research, Daping Hospital, Army Medical University (Third Military Medical University), No. 10, Changjiang Zhilu, Da Ping, Yuzhong District, Chongqing 400042, China. Electronic address:

Objective: We aimed to identify plasma cytokine biomarkers that differentiate the infection stages of Mycobacterium tuberculosis (MTB).

Methods: This study included a total of 227 subjects consisting of active tuberculosis (ATB) patients, latent tuberculosis infection (LTBI) individuals, and healthy controls (HC). We analyzed the expressions of 38 plasma cytokines in the discovery cohort to identify the biosignatures for differentiating MTB infection states, area under the curve (AUC) were used to evaluate the diagnostic efficiency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453183035
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http://dx.doi.org/10.1016/j.jinf.2018.10.017DOI Listing
December 2018
1 Read

Varicella vaccine effectiveness over 10 years in Australia; moderate protection from 1-dose program.

J Infect 2018 Dec 6. Epub 2018 Dec 6.

National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (NCIRS), Children's Hospital at Westmead, Cnr Hawkesbury Road and Hainsworth Street, Westmead, NSW 2145, Australia; Discipline of Child and Adolescent Health, University of Sydney, Sydney, Australia; Children's Hospital at Westmead, Sydney, Australia.

Objectives: To examine the impact of Australia's single dose infant varicella vaccination program, we assessed single dose varicella vaccine effectiveness (VE) in preventing hospitalised disease using two methods.

Methods: Clinically confirmed varicella cases from the Paediatric Active Enhanced Disease Surveillance (PAEDS) sentinel network were age-matched to 20 controls obtained from the Australian Immunisation Register. Conditional logistic regression models were used to estimate VE and compared with estimates obtained using our second approach. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.11.009DOI Listing
December 2018
1 Read

Interplay of personal, pet, and environmental colonization in households affected by community-associated methicillin-resistant Staphylococcus aureus.

J Infect 2018 Nov 29. Epub 2018 Nov 29.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Objective: We sought to determine the prevalence, molecular epidemiology, and factors associated with Staphylococcus aureus environmental surface and pet colonization in households of children with community-associated methicillin-resistant S. aureus (CA-MRSA) infection.

Methods: Between 2012 and 2015, 150 children with CA-MRSA infections and their household contacts and pets were enrolled in this cross-sectional study in metropolitan Saint Louis, MO. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.11.006DOI Listing
November 2018
2 Reads

Whole Genome Sequencing detects Inter-Facility Transmission of Carbapenem-resistant Klebsiella pneumoniae.

J Infect 2018 Nov 29. Epub 2018 Nov 29.

Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, 9331 Robert D. Snyder Road, Charlotte NC 28223, USA. Electronic address:

Objectives: To identify transmission patterns of Carbapenem-resistant Klebsiella pneumoniae infection during an outbreak at a large, tertiary care hospital and to detect whether the outbreak organisms spread to other facilities in the integrated healthcare network.

Methods: We analyzed 71 K. pneumoniae whole genome sequences collected from clinical specimens before, during and after the outbreak and reviewed corresponding patient medical records. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453183034
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http://dx.doi.org/10.1016/j.jinf.2018.11.003DOI Listing
November 2018
5 Reads

Redefining influenza seasonality at a global scale and aligning it to the influenza vaccine manufacturing cycle: A descriptive time series analysis.

J Infect 2019 Feb 23;78(2):140-149. Epub 2018 Nov 23.

School of Public Health and Community Medicine, University of New South Wales, UNSW Sydney, NSW 2052, Australia. Electronic address:

Objectives: Annual seasonal influenza vaccine manufacturing cycles align with temperate country seasonality in each hemisphere, yet influenza seasonality is poorly defined for many countries. The study introduces a novel and universal approach to defining and classifying seasonality that can be used to classify any country's influenza vaccine cycle alignment.

Methods: Countries reporting to the World Health Organization's FluNet influenza virology database in 90% of weeks during 2011 through 2017 were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453183030
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http://dx.doi.org/10.1016/j.jinf.2018.10.006DOI Listing
February 2019
1 Read

Next-generation sequencing of the BALF in the diagnosis of community-acquired pneumonia in immunocompromised patients.

J Infect 2018 Nov 23. Epub 2018 Nov 23.

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.11.005DOI Listing
November 2018
1 Read

Invasive meningococcal disease as a cause of sudden and unexpected death in a teenager: The public health importance of confirming the diagnosis.

J Infect 2018 Nov 23. Epub 2018 Nov 23.

Public Health England, Immunisation and Countermeasures Division, 61 Colindale Avenue, London NW9 5EQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.11.004DOI Listing
November 2018
7 Reads

Wide spectrum of referral routes for acute hepatitis E infections.

J Infect 2018 Nov 22. Epub 2018 Nov 22.

Clinical Microbiology, University Hospitals of Leicester NHS Trust, Level 5 Sandringham Building, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.11.002DOI Listing
November 2018
4 Reads

Fluoroquinolone use and associated adverse drug events in England.

J Infect 2018 Nov 13. Epub 2018 Nov 13.

Unit of Oral and Maxillofacial Medicine, Surgery and Pathology, University of Sheffield School of Clinical Dentistry, Claremont Crescent, Sheffield S10 2TA, UK.

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http://dx.doi.org/10.1016/j.jinf.2018.11.001DOI Listing
November 2018

Reactivation of dormant/latent fungal infection.

J Infect 2018 Dec 6;77(6):463-468. Epub 2018 Jul 6.

INSERM U1070, Université de Poitiers, Poitiers, France; Faculté de médecine et pharmacie, Université de Poitiers, Poitiers, France; Service de maladies infectieuses et tropicales, CHU de Poitiers, Poitiers, France.

Objectives: Latent infections are well-known for bacteria such as Mycobacterium tuberculosis and for viruses such as Herpesviridae and parasites like Leishmania spp. or Toxoplasma gondii. However, invasive fungi may also be latent and come to reactivate. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.06.016DOI Listing
December 2018
2 Reads

Unusual Neisseria species as a cause of infection in patients taking eculizumab.

J Infect 2019 Feb 6;78(2):113-118. Epub 2018 Nov 6.

Division of Pharmacovigilance, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

Background: Non-meningococcal, non-gonococcal Neisseria spp. are typically commensal and rarely cause invasive disease. Eculizumab is a terminal complement inhibitor that increases susceptibility to meningococcal disease, but data on disease caused by typically-commensal Neisseria spp. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453183032
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http://dx.doi.org/10.1016/j.jinf.2018.10.015DOI Listing
February 2019
15 Reads

Bronchoalveolar lavage Aspergillus Galactomannan lateral flow assay versus Aspergillus-specific lateral flow device test for diagnosis of invasive pulmonary Aspergillosis in patients with hematological malignancies.

J Infect 2018 Nov 2. Epub 2018 Nov 2.

Department of Medicine, University of California San Diego, San Diego, CA, United States; Department of Medicine, Medical University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.10.014DOI Listing
November 2018
2 Reads

Genomes of Escherichia coli bacteraemia isolates originating from urinary tract foci contain more virulence-associated genes than those from non-urinary foci and neutropaenic hosts.

J Infect 2018 Dec 2;77(6):534-543. Epub 2018 Nov 2.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, LC71A, C Level, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, UK.

Objectives: Escherichia coli is the leading cause of bacteraemia. In an era of emerging multi-drug-resistant strains, development of effective preventative strategies will be informed by knowledge of strain diversity associated with specific infective syndromes/patient groups. We hypothesised that the number of virulence factor (VF) genes amongst bacteraemia isolates from neutropaenic patients would be lower than isolates from immunocompetent patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453183031
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http://dx.doi.org/10.1016/j.jinf.2018.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293314PMC
December 2018
10 Reads
4.441 Impact Factor

The burden of serious fungal disease in the UK - infections with "rare" organisms.

J Infect 2018 Dec 31;77(6):561-571. Epub 2018 Oct 31.

PHE UK National Mycology Reference Laboratory, Science Quarter, Southmead Hospital, Bristol, United Kingdom.

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http://dx.doi.org/10.1016/j.jinf.2018.10.010DOI Listing
December 2018
6 Reads

First report of a novel HIV-1 recombinant form (CRF100_01C) comprising CRF01_AE and C among heterosexuals in Yunnan, China.

J Infect 2018 Dec 30;77(6):561-571. Epub 2018 Oct 30.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.10.009DOI Listing
December 2018
1 Read

Rapid evolving H7N9 avian influenza A viruses pose new challenge.

J Infect 2018 Oct 24. Epub 2018 Oct 24.

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.10.008DOI Listing
October 2018
1 Read

Tolerance of MRSA ST239-TW to chlorhexidine-based decolonization: Evidence for keratinocyte invasion as a mechanism of biocide evasion.

J Infect 2019 Feb 24;78(2):119-126. Epub 2018 Oct 24.

Department of Infectious Diseases, Centre for Clinical Infection and Diagnostics Research (CIDR), King's College London & Guy's and St. Thomas' NHS Foundation Trust (GSTT), London, UK.

Objectives: Information on genetic determinants of chlorhexidine tolerance (qacA carriage and MIC) in vitro is available, although evidence of the clinical impact and mechanisms remain poorly understood. We investigated why, following chlorhexidine intervention, prevalent epidemic MRSA ST22 and ST36 clones declined at an ICU, whilst an ST239-TW clone did not. The chlorhexidine tolerant ST239-TW phenotypes were assessed for their protein binding, cell adhesion and intracellular uptake potential. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.10.007DOI Listing
February 2019

Risk factors of multidrug-resistant tuberculosis: A global systematic review and meta-analysis.

J Infect 2018 Dec 16;77(6):469-478. Epub 2018 Oct 16.

University of Groningen, University Medical Centrum Groningen, Department of Clinical Pharmacy and Pharmacology, The Netherlands.

Objectives: Since the risk of multidrug-resistant tuberculosis (MDR-TB) may depend on the setting, we aimed to determine the associations of risk factors of MDR-TB across different regions.

Methods: A systematic review and meta-analysis was performed with Pubmed and Embase databases. Information was retrieved on 37 pre-defined risk factors of MDR-TB. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.10.004DOI Listing
December 2018

Gut dysbiosis and paediatric Crohn's disease.

J Infect 2019 Jan 16;78(1):1-7. Epub 2018 Oct 16.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, Perugia 06129, Italy. Electronic address:

Objectives: The main objective of this manuscript is to discuss our present knowledge of the relationships between dysbiosis and paediatric Crohn's disease (CD). The therapeutic role of the methods currently used to re-establish normal gut microbiota composition is also analysed.

Methods: PubMed was used to search for all of the studies published from January 2008 to June 2018 using the key words: "Crohn's disease" and "gut dysbiosis" or "microbiota" or "microbioma" or "probiotic" and "children" or "paediatric". Read More

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January 2019
11 Reads

Risk factors for mortality among carbapenem-resistant enterobacteriaceae carriers with focus on immunosuppression.

J Infect 2019 Feb 10;78(2):101-105. Epub 2018 Oct 10.

Division of Infectious disease, Rambam Health Care Campus & Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel.

Objectives: To identify risk factors for mortality in a cohort of carbapenem-resistant enterobacteriaceae (CRE) carriers, focusing on immunosuppression and other risk factors known at the time of CRE carriage detection.

Methods: We prospectively followed all new and known CRE carriers admitted between June 2016 and June 2017 to a single tertiary center in Israel. Patients were included in the study after confirmation of the carrier state. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.10.003DOI Listing
February 2019
3 Reads

Identification of musculoskeletal infection with non-tuberculous mycobacterium using metagenomic sequencing.

J Infect 2019 Feb 10;78(2):158-169. Epub 2018 Oct 10.

Department of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, No.20 Chazhong Road, Fuzhou 350005, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2018.10.002DOI Listing
February 2019
1 Read

Microbiological and clinical characteristics of Acinetobacter baumannii bacteremia: Implications of sequence type for prognosis.

J Infect 2019 Feb 8;78(2):106-112. Epub 2018 Oct 8.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Objectives: Acinetobacter baumannii (Ab) is an important cause of healthcare-associated infections. Multilocus sequence typing (MLST) provides a highly discriminative typing method. We aimed to determine the clinical impact of Ab sequence types (ST) in patients with bloodstream infection (BSI). Read More

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http://dx.doi.org/10.1016/j.jinf.2018.10.001DOI Listing
February 2019
2 Reads

Missed hepatitis B birth dose vaccine is a risk factor for incomplete vaccination at 18 and 24 months.

J Infect 2019 Feb 4;78(2):134-139. Epub 2018 Oct 4.

Department of Pediatrics, Division of Infectious Diseases, University of North Carolina, 038 MacNider Hall, CB #7231, United States.

Objectives: To determine whether missing the HepB birth dose vaccine is a risk factor for incomplete vaccination later in childhood.

Methods: This was a retrospective cohort study of infants born over one year at an academic medical center. The "not vaccinated at birth" group consisted of all infants who did not receive the HepB birth dose vaccine by seven days of life, while the "vaccinated at birth" group included infants who did receive the birth dose. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.09.014DOI Listing
February 2019
14 Reads

PCR cycle threshold to assess a diagnostic stewardship intervention for C. difficile testing.

J Infect 2019 Feb 28;78(2):158-169. Epub 2018 Sep 28.

Division of Infectious Diseases & International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA; Office of Hospital Epidemiology/Infection Prevention & Control, University of Virginia Health System, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.jinf.2018.09.013DOI Listing
February 2019
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Epidemiologic estimates of hepatitis E virus infection in European countries.

J Infect 2018 Dec 27;77(6):544-552. Epub 2018 Sep 27.

Department of Epidemiology, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany; Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. Electronic address:

Objectives: Reliable epidemiologic estimates of Hepatitis E Virus (HEV) infection and evidence on factors determining country-differences are sparse. We systematically assessed and extracted research data on three HEV infection markers and identified factors influencing HEV-positivity to generated adjusted EU/EEA country-specific estimates by a meta-analysis.

Methods: Reports on HEV published 2005-2015 for EU/EEA countries were obtained from PubMed, Embase, Scopus, and Cochrane databases. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.09.012DOI Listing
December 2018
13 Reads

Herpes simplex virus (HSV) pneumonia in the non-ventilated immunocompromised host: Burden and predictors.

J Infect 2019 Feb 26;78(2):127-133. Epub 2018 Sep 26.

Pulmonology Unit, University Hospital of Trieste, Strada di Fiume 447, 34149 Trieste, Italy.

Objectives: To evaluate burden and predictors of HSV pneumonia among immunocompromised patients not undergoing invasive mechanical ventilation according to a tailored diagnostic algorithm.

Methods: This prospective, observational study included immunocompromised adults with pneumonia non-responding to empirical antibiotic therapy. Bronchoalveolar lavage (BAL) specimens were cultured for bacteria, mycobacteria and fungi. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.09.010DOI Listing
February 2019
9 Reads

Triacetylfusarinine C: A urine biomarker for diagnosis of invasive aspergillosis.

J Infect 2019 Feb 26;78(2):150-157. Epub 2018 Sep 26.

Division of Molecular Biology, Medical University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address:

Objectives: Early diagnosis of invasive aspergillosis (IA) remains challenging, with available diagnostics being limited by inadequate sensitivities and specificities. Triacetylfusarinine C, a fungal siderophore that has been shown to accumulate in urine in animal models, is a potential new biomarker for diagnosis of IA.

Methods: We developed a method allowing absolute and matrix-independent mass spectrometric quantification of TAFC. Read More

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http://dx.doi.org/10.1016/j.jinf.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361682PMC
February 2019
14 Reads